locus-tag	class	description
IAG42_RS00180	COG1414	Transcriptional regulator
IAG42_RS00185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAG42_RS00200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IAG42_RS00215	COG1175	transmembrane transport
IAG42_RS00220	COG0395	ABC-type sugar transport system, permease component
IAG42_RS00235	COG3458	cephalosporin-C deacetylase activity
IAG42_RS00265	COG2182	Extracellular solute-binding protein
IAG42_RS00270	COG1175	transmembrane transport
IAG42_RS00275	COG0395	ABC-type sugar transport system, permease component
IAG42_RS00285	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IAG42_RS00295	COG0783	Belongs to the Dps family
IAG42_RS00300	COG2259	Doxx family
IAG42_RS00305	COG1335	isochorismatase
IAG42_RS00335	COG2272	Belongs to the type-B carboxylesterase lipase family
IAG42_RS00365	COG1309	transcriptional regulator
IAG42_RS00375	COG1063	alcohol dehydrogenase
IAG42_RS00380	COG0667	Aldo Keto reductase
IAG42_RS00390	COG0656	L-ascorbic acid biosynthetic process
IAG42_RS00440	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS00465	COG1940	carbohydrate kinase activity
IAG42_RS00470	COG1653	transport
IAG42_RS00475	COG1175	transmembrane transport
IAG42_RS00480	COG0395	ABC-type sugar transport system, permease component
IAG42_RS00500	COG3537	Alpha-1,2-mannosidase
IAG42_RS00505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IAG42_RS00540	COG2197	response regulator
IAG42_RS00540	COG3903	Transcriptional regulator
IAG42_RS00545	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IAG42_RS00550	COG1609	Transcriptional regulator
IAG42_RS00555	COG2182	Extracellular solute-binding protein
IAG42_RS00560	COG1175	transmembrane transport
IAG42_RS00570	COG1472	Belongs to the glycosyl hydrolase 3 family
IAG42_RS00595	COG4977	sequence-specific DNA binding
IAG42_RS00615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IAG42_RS00670	COG1725	Transcriptional regulator
IAG42_RS00710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IAG42_RS00740	COG1733	regulation of RNA biosynthetic process
IAG42_RS00755	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IAG42_RS00785	COG1937	Protein conserved in bacteria
IAG42_RS00790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAG42_RS00810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IAG42_RS00810	COG0574	Belongs to the PEP-utilizing enzyme family
IAG42_RS00820	COG3383	formate dehydrogenase (NAD+) activity
IAG42_RS00825	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IAG42_RS00830	COG2239	Acts as a magnesium transporter
IAG42_RS00860	COG2205	protein histidine kinase activity
IAG42_RS00865	COG0745	RESPONSE REGULATOR receiver
IAG42_RS00905	COG0516	GMP reductase activity
IAG42_RS00905	COG0517	IMP dehydrogenase activity
IAG42_RS00940	COG1063	alcohol dehydrogenase
IAG42_RS00945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IAG42_RS00950	COG0516	GMP reductase activity
IAG42_RS00950	COG0517	IMP dehydrogenase activity
IAG42_RS00955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IAG42_RS00980	COG1136	(ABC) transporter
IAG42_RS01010	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS01030	COG0534	Mate efflux family protein
IAG42_RS01040	COG3469	chitinase activity
IAG42_RS01050	COG1609	Transcriptional regulator
IAG42_RS01060	COG0477	Major facilitator Superfamily
IAG42_RS01100	COG1414	Transcriptional regulator
IAG42_RS01120	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IAG42_RS01130	COG2318	DinB family
IAG42_RS01150	COG0346	lactoylglutathione lyase activity
IAG42_RS01175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAG42_RS01200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAG42_RS01210	COG4209	transmembrane transport
IAG42_RS01215	COG0395	ABC-type sugar transport system, permease component
IAG42_RS01285	COG0477	Major facilitator Superfamily
IAG42_RS01345	COG2010	Cytochrome c
IAG42_RS01345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IAG42_RS01350	COG2080	2 iron, 2 sulfur cluster binding
IAG42_RS01395	COG0640	Transcriptional regulator
IAG42_RS01410	COG1309	transcriptional regulator
IAG42_RS01430	COG2409	Drug exporters of the RND superfamily
IAG42_RS01495	COG0583	DNA-binding transcription factor activity
IAG42_RS01510	COG0666	response to abiotic stimulus
IAG42_RS01515	COG2318	DinB family
IAG42_RS01520	COG0596	Alpha beta hydrolase
IAG42_RS01575	COG3896	Chloramphenicol phosphotransferase-like protein
IAG42_RS01595	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IAG42_RS01620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IAG42_RS01625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAG42_RS01685	COG1120	ATPase activity
IAG42_RS01710	COG1073	alpha beta
IAG42_RS01730	COG2755	lipolytic protein G-D-S-L family
IAG42_RS01810	COG0180	Tryptophanyl-tRNA synthetase
IAG42_RS01815	COG2124	cytochrome p450
IAG42_RS01825	COG2837	iron assimilation
IAG42_RS01840	COG1819	glycosyl
IAG42_RS01845	COG0789	Transcriptional regulator
IAG42_RS01905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAG42_RS01910	COG2188	Transcriptional regulator
IAG42_RS01940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IAG42_RS01970	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS01980	COG2890	protein-(glutamine-N5) methyltransferase activity
IAG42_RS01985	COG0330	HflC and HflK could
IAG42_RS01995	COG1309	transcriptional regulator
IAG42_RS02035	COG2814	Major facilitator Superfamily
IAG42_RS02075	COG3594	Acyltransferase
IAG42_RS02085	COG0069	glutamate synthase activity
IAG42_RS02100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAG42_RS02110	COG0390	transport system, permease component
IAG42_RS02115	COG1793	dna ligase
IAG42_RS02175	COG1940	carbohydrate kinase activity
IAG42_RS02190	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS02205	COG1737	Transcriptional regulator
IAG42_RS02215	COG1126	abc transporter atp-binding protein
IAG42_RS02220	COG0765	amino acid transport
IAG42_RS02225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAG42_RS02260	COG2986	histidine ammonia-lyase
IAG42_RS02265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IAG42_RS02270	COG2124	cytochrome p450
IAG42_RS02295	COG1137	ATPase activity
IAG42_RS02300	COG0559	Belongs to the binding-protein-dependent transport system permease family
IAG42_RS02310	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS02320	COG1309	transcriptional regulator
IAG42_RS02325	COG0110	maltose O-acetyltransferase activity
IAG42_RS02365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IAG42_RS02400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAG42_RS02410	COG2814	Major facilitator Superfamily
IAG42_RS02415	COG2175	clavaminate synthase activity
IAG42_RS02425	COG3246	L-lysine catabolic process to acetate
IAG42_RS02440	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS02475	COG0745	RESPONSE REGULATOR receiver
IAG42_RS02480	COG2205	protein histidine kinase activity
IAG42_RS02520	COG0583	DNA-binding transcription factor activity
IAG42_RS02525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IAG42_RS02560	COG2235	arginine
IAG42_RS02570	COG1595	DNA-templated transcription, initiation
IAG42_RS02580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG42_RS02585	COG1120	ATPase activity
IAG42_RS02590	COG0009	L-threonylcarbamoyladenylate synthase
IAG42_RS02630	COG0444	Belongs to the ABC transporter superfamily
IAG42_RS02635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG42_RS02640	COG0601	transmembrane transport
IAG42_RS02650	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS02655	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS02680	COG3467	pyridoxamine 5'-phosphate
IAG42_RS02685	COG1024	Enoyl-CoA hydratase
IAG42_RS02695	COG0477	Major facilitator Superfamily
IAG42_RS02710	COG0247	lactate metabolic process
IAG42_RS02715	COG1139	Iron-sulfur cluster binding protein
IAG42_RS02720	COG1556	Lactate utilization protein
IAG42_RS02725	COG0517	IMP dehydrogenase activity
IAG42_RS02725	COG1125	glycine betaine transport
IAG42_RS02735	COG1174	glycine betaine transport
IAG42_RS02740	COG1174	glycine betaine transport
IAG42_RS02765	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IAG42_RS02830	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IAG42_RS02835	COG1573	uracil-dna glycosylase
IAG42_RS02845	COG0288	reversible hydration of carbon dioxide
IAG42_RS02875	COG1733	regulation of RNA biosynthetic process
IAG42_RS02905	COG1309	transcriptional regulator
IAG42_RS02910	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS02950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG42_RS02970	COG3485	protocatechuate 3,4-dioxygenase
IAG42_RS02975	COG1454	alcohol dehydrogenase
IAG42_RS02985	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IAG42_RS02995	COG2226	methyltransferase
IAG42_RS03035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAG42_RS03045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IAG42_RS03065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAG42_RS03070	COG1834	amidinotransferase
IAG42_RS03085	COG1733	regulation of RNA biosynthetic process
IAG42_RS03090	COG1301	dicarboxylic acid transport
IAG42_RS03115	COG1113	amino acid transport
IAG42_RS03120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IAG42_RS03130	COG1126	abc transporter atp-binding protein
IAG42_RS03135	COG0765	amino acid transport
IAG42_RS03145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IAG42_RS03175	COG0517	IMP dehydrogenase activity
IAG42_RS03175	COG0516	GMP reductase activity
IAG42_RS03190	COG1063	alcohol dehydrogenase
IAG42_RS03195	COG0517	IMP dehydrogenase activity
IAG42_RS03195	COG0516	GMP reductase activity
IAG42_RS03205	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS03215	COG2186	Transcriptional regulator
IAG42_RS03245	COG2124	cytochrome p450
IAG42_RS03255	COG2890	protein-(glutamine-N5) methyltransferase activity
IAG42_RS03275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS03280	COG1335	isochorismatase
IAG42_RS03320	COG0366	Alpha amylase catalytic
IAG42_RS03330	COG3281	Trehalose synthase
IAG42_RS03335	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IAG42_RS03360	COG1982	Orn Lys Arg decarboxylase major
IAG42_RS03400	COG1006	Multisubunit Na H antiporter MnhC subunit
IAG42_RS03405	COG0651	ATP synthesis coupled electron transport
IAG42_RS03410	COG0247	lactate metabolic process
IAG42_RS03410	COG0277	FAD linked oxidase domain protein
IAG42_RS03415	COG0028	Belongs to the TPP enzyme family
IAG42_RS03430	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS03465	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS03475	COG1063	alcohol dehydrogenase
IAG42_RS03485	COG1695	Transcriptional regulator
IAG42_RS03490	COG1053	succinate dehydrogenase
IAG42_RS03530	COG1309	transcriptional regulator
IAG42_RS03540	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS03600	COG1968	undecaprenyl-diphosphatase activity
IAG42_RS03615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAG42_RS03615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IAG42_RS03625	COG0730	response to heat
IAG42_RS03640	COG3246	L-lysine catabolic process to acetate
IAG42_RS03645	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG42_RS03665	COG4552	Acetyltransferase involved in intracellular survival and related
IAG42_RS03705	COG4770	biotin carboxylase activity
IAG42_RS03715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG42_RS03720	COG1268	BioY protein
IAG42_RS03730	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS03735	COG1132	(ABC) transporter
IAG42_RS03755	COG0542	response to heat
IAG42_RS03790	COG1309	transcriptional regulator
IAG42_RS03795	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS03830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS03835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS03855	COG0583	DNA-binding transcription factor activity
IAG42_RS03875	COG2409	Drug exporters of the RND superfamily
IAG42_RS03900	COG2813	Specifically methylates the guanine in position
IAG42_RS03915	COG2132	Multicopper oxidase
IAG42_RS03955	COG0243	molybdopterin cofactor binding
IAG42_RS03995	COG2252	PERMEase
IAG42_RS04025	COG1408	metallophosphoesterase
IAG42_RS04035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAG42_RS04050	COG2391	methyltransferase activity
IAG42_RS04060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAG42_RS04065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAG42_RS04070	COG1609	Transcriptional regulator
IAG42_RS04095	COG3572	ergothioneine biosynthetic process
IAG42_RS04100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IAG42_RS04105	COG0121	glutamine amidotransferase
IAG42_RS04110	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IAG42_RS04115	COG2182	Extracellular solute-binding protein
IAG42_RS04130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS04155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IAG42_RS04160	COG1053	succinate dehydrogenase
IAG42_RS04230	COG0531	amino acid
IAG42_RS04240	COG0395	ABC-type sugar transport system, permease component
IAG42_RS04245	COG4209	transmembrane transport
IAG42_RS04275	COG3275	phosphorelay sensor kinase activity
IAG42_RS04280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG42_RS04300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IAG42_RS04345	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS04350	COG4948	Mandelate Racemase Muconate Lactonizing
IAG42_RS04360	COG1129	ABC transporter
IAG42_RS04365	COG1879	ABC-type sugar transport system periplasmic component
IAG42_RS04370	COG2186	Transcriptional regulator
IAG42_RS04395	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IAG42_RS04410	COG0785	Cytochrome C biogenesis protein
IAG42_RS04415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IAG42_RS04415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IAG42_RS04430	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS04445	COG0477	Major facilitator Superfamily
IAG42_RS04450	COG1473	amidohydrolase
IAG42_RS04460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IAG42_RS04465	COG0297	glycogen (starch) synthase activity
IAG42_RS04480	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IAG42_RS04500	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IAG42_RS04540	COG1024	Enoyl-CoA hydratase
IAG42_RS04590	COG1733	regulation of RNA biosynthetic process
IAG42_RS04615	COG0701	Predicted permease
IAG42_RS04625	COG0640	Transcriptional regulator
IAG42_RS04645	COG0477	Major facilitator Superfamily
IAG42_RS04660	COG1619	proteins homologs of microcin C7 resistance protein MccF
IAG42_RS04665	COG2770	Histidine kinase
IAG42_RS04665	COG2208	phosphoserine phosphatase activity
IAG42_RS04700	COG0693	protein deglycase activity
IAG42_RS04705	COG0539	negative regulation of cytoplasmic translation
IAG42_RS04715	COG0583	DNA-binding transcription factor activity
IAG42_RS04725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAG42_RS04735	COG0515	serine threonine protein kinase
IAG42_RS04750	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IAG42_RS04765	COG2030	dehydratase
IAG42_RS04770	COG0183	Belongs to the thiolase family
IAG42_RS04780	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS04785	COG2030	dehydratase
IAG42_RS04790	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS04795	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS04805	COG2267	carboxylic ester hydrolase activity
IAG42_RS04810	COG1414	Transcriptional regulator
IAG42_RS04825	COG1132	(ABC) transporter
IAG42_RS04830	COG1472	Belongs to the glycosyl hydrolase 3 family
IAG42_RS04835	COG1024	Enoyl-CoA hydratase
IAG42_RS04870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IAG42_RS04875	COG0668	transmembrane transport
IAG42_RS04885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IAG42_RS04890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IAG42_RS04900	COG0402	S-adenosylhomocysteine deaminase activity
IAG42_RS04910	COG0549	Belongs to the carbamate kinase family
IAG42_RS04915	COG2508	Transcriptional regulator
IAG42_RS04990	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS04995	COG0183	Belongs to the thiolase family
IAG42_RS05070	COG3226	Transcriptional regulator
IAG42_RS05075	COG0110	maltose O-acetyltransferase activity
IAG42_RS05110	COG0583	DNA-binding transcription factor activity
IAG42_RS05120	COG1063	alcohol dehydrogenase
IAG42_RS05130	COG0673	inositol 2-dehydrogenase activity
IAG42_RS05150	COG0395	ABC-type sugar transport system, permease component
IAG42_RS05155	COG4209	transmembrane transport
IAG42_RS05165	COG1609	Transcriptional regulator
IAG42_RS05210	COG2072	flavoprotein involved in K transport
IAG42_RS05230	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS05240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IAG42_RS05250	COG0531	amino acid
IAG42_RS05265	COG2755	lipolytic protein G-D-S-L family
IAG42_RS05295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IAG42_RS05300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IAG42_RS05315	COG1657	PFAM Prenyltransferase squalene oxidase
IAG42_RS05325	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IAG42_RS05340	COG1562	ergosterol biosynthetic process
IAG42_RS05345	COG1134	teichoic acid transport
IAG42_RS05370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IAG42_RS05390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IAG42_RS05390	COG4106	trans-aconitate 2-methyltransferase activity
IAG42_RS05395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IAG42_RS05410	COG1024	Enoyl-CoA hydratase
IAG42_RS05420	COG4977	sequence-specific DNA binding
IAG42_RS05430	COG2183	response to ionizing radiation
IAG42_RS05435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAG42_RS05440	COG0488	(ABC) transporter
IAG42_RS05455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IAG42_RS05465	COG2936	dipeptidyl-peptidase activity
IAG42_RS05485	COG1113	amino acid transport
IAG42_RS05490	COG0789	Transcriptional regulator
IAG42_RS05495	COG1024	Enoyl-CoA hydratase
IAG42_RS05495	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG42_RS05500	COG0183	Belongs to the thiolase family
IAG42_RS05505	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS05510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG42_RS05515	COG3268	Saccharopine dehydrogenase
IAG42_RS05520	COG1515	deoxyribonuclease V activity
IAG42_RS05540	COG0488	(ABC) transporter
IAG42_RS05610	COG1793	dna ligase
IAG42_RS05655	COG3511	phospholipase C
IAG42_RS05670	COG1486	melibiose metabolic process
IAG42_RS05695	COG0477	Major facilitator Superfamily
IAG42_RS05725	COG1802	Transcriptional regulator
IAG42_RS05730	COG2271	Major facilitator Superfamily
IAG42_RS05750	COG0154	amidase activity
IAG42_RS05760	COG3408	Glycogen debranching enzyme
IAG42_RS05760	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IAG42_RS05780	COG1653	transport
IAG42_RS05785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IAG42_RS05790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IAG42_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS05805	COG1802	Transcriptional regulator
IAG42_RS05845	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IAG42_RS05860	COG3903	Transcriptional regulator
IAG42_RS05860	COG3629	intracellular signal transduction
IAG42_RS05870	COG2255	four-way junction helicase activity
IAG42_RS05895	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS05905	COG0045	succinate-CoA ligase (ADP-forming) activity
IAG42_RS05915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG42_RS05925	COG2223	nitrite transmembrane transporter activity
IAG42_RS05965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IAG42_RS05990	COG1879	ABC-type sugar transport system periplasmic component
IAG42_RS05995	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAG42_RS06000	COG1129	ABC transporter
IAG42_RS06005	COG1940	carbohydrate kinase activity
IAG42_RS06025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IAG42_RS06030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IAG42_RS06035	COG3383	formate dehydrogenase (NAD+) activity
IAG42_RS06040	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IAG42_RS06050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IAG42_RS06100	COG0656	L-ascorbic acid biosynthetic process
IAG42_RS06115	COG2154	pterin-4-alpha-carbinolamine dehydratase
IAG42_RS06135	COG1140	nitrate reductase beta subunit
IAG42_RS06160	COG2186	Transcriptional regulator
IAG42_RS06175	COG0531	amino acid
IAG42_RS06210	COG0488	(ABC) transporter
IAG42_RS06215	COG1597	lipid kinase activity
IAG42_RS06220	COG2226	methyltransferase
IAG42_RS06290	COG1228	amidohydrolase
IAG42_RS06295	COG0402	S-adenosylhomocysteine deaminase activity
IAG42_RS06330	COG1619	proteins homologs of microcin C7 resistance protein MccF
IAG42_RS06335	COG1506	peptidase
IAG42_RS06335	COG0823	Involved in the tonB-independent uptake of proteins
IAG42_RS06335	COG4946	Tricorn protease homolog
IAG42_RS06340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAG42_RS06345	COG2362	D-Aminopeptidase
IAG42_RS06350	COG2226	methyltransferase
IAG42_RS06385	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG42_RS06400	COG0604	alcohol dehydrogenase
IAG42_RS06405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG42_RS06405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG42_RS06420	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS06425	COG0688	phosphatidylethanolamine metabolic process
IAG42_RS06435	COG1929	Belongs to the glycerate kinase type-1 family
IAG42_RS06445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IAG42_RS06450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IAG42_RS06460	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IAG42_RS06470	COG0483	inositol monophosphate 1-phosphatase activity
IAG42_RS06480	COG1278	Cold shock
IAG42_RS06505	COG2205	protein histidine kinase activity
IAG42_RS06510	COG0745	RESPONSE REGULATOR receiver
IAG42_RS06535	COG1953	Uracil, thiamine, allantoin
IAG42_RS06540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS06545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IAG42_RS06560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAG42_RS06585	COG2197	response regulator
IAG42_RS06590	COG4585	Histidine kinase
IAG42_RS06595	COG0405	Gamma-glutamyltransferase
IAG42_RS06605	COG0765	amino acid transport
IAG42_RS06610	COG0765	amino acid transport
IAG42_RS06615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAG42_RS06620	COG1126	abc transporter atp-binding protein
IAG42_RS06640	COG1335	isochorismatase
IAG42_RS06650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG42_RS06670	COG2867	negative regulation of translational initiation
IAG42_RS06675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG42_RS06720	COG0069	glutamate synthase activity
IAG42_RS06730	COG2208	phosphoserine phosphatase activity
IAG42_RS06730	COG2770	Histidine kinase
IAG42_RS06755	COG1940	carbohydrate kinase activity
IAG42_RS06765	COG4214	carbohydrate transport
IAG42_RS06780	COG2188	Transcriptional regulator
IAG42_RS06785	COG0673	inositol 2-dehydrogenase activity
IAG42_RS06795	COG2197	response regulator
IAG42_RS06815	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS06820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IAG42_RS06825	COG1414	Transcriptional regulator
IAG42_RS06830	COG0577	efflux transmembrane transporter activity
IAG42_RS06830	COG1136	(ABC) transporter
IAG42_RS06835	COG0577	efflux transmembrane transporter activity
IAG42_RS06840	COG4585	Histidine kinase
IAG42_RS06845	COG2197	response regulator
IAG42_RS06855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAG42_RS06865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IAG42_RS06865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IAG42_RS06870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IAG42_RS06895	COG1733	regulation of RNA biosynthetic process
IAG42_RS06900	COG0436	Aminotransferase
IAG42_RS06935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IAG42_RS06940	COG0588	phosphoglycerate mutase activity
IAG42_RS06975	COG0714	Associated with various cellular activities
IAG42_RS06985	COG2233	PERMEase
IAG42_RS06995	COG2233	PERMEase
IAG42_RS07005	COG2351	hydroxyisourate hydrolase activity
IAG42_RS07025	COG3622	Belongs to the hyi family
IAG42_RS07030	COG2084	Dehydrogenase
IAG42_RS07035	COG0753	catalase activity
IAG42_RS07045	COG3960	tartronate-semialdehyde synthase activity
IAG42_RS07060	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS07065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAG42_RS07070	COG2197	response regulator
IAG42_RS07095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IAG42_RS07100	COG2610	gluconate transmembrane transporter activity
IAG42_RS07110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IAG42_RS07115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IAG42_RS07135	COG0367	asparagine synthase
IAG42_RS07160	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS07170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IAG42_RS07185	COG4310	Domain of unknown function (DUF2172)
IAG42_RS07195	COG1215	transferase activity, transferring glycosyl groups
IAG42_RS07210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IAG42_RS07230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IAG42_RS07240	COG2233	PERMEase
IAG42_RS07245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IAG42_RS07250	COG1993	acr, cog1993
IAG42_RS07255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IAG42_RS07265	COG0726	polysaccharide deacetylase
IAG42_RS07280	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IAG42_RS07280	COG3608	succinylglutamate desuccinylase aspartoacylase
IAG42_RS07285	COG2252	PERMEase
IAG42_RS07290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IAG42_RS07305	COG3835	regulator
IAG42_RS07315	COG1802	Transcriptional regulator
IAG42_RS07340	COG0028	Belongs to the TPP enzyme family
IAG42_RS07350	COG1404	Belongs to the peptidase S8 family
IAG42_RS07370	COG2353	YceI-like domain
IAG42_RS07375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IAG42_RS07385	COG1162	GTPase activity
IAG42_RS07395	COG0789	Transcriptional regulator
IAG42_RS07400	COG2130	NADP-dependent
IAG42_RS07430	COG3938	Belongs to the proline racemase family
IAG42_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS07470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IAG42_RS07475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAG42_RS07480	COG2146	nitrite reductase [NAD(P)H] activity
IAG42_RS07485	COG1414	Transcriptional regulator
IAG42_RS07495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAG42_RS07505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAG42_RS07515	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS07535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IAG42_RS07540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAG42_RS07550	COG3290	protein histidine kinase activity
IAG42_RS07555	COG4565	transcriptional regulatory protein
IAG42_RS07570	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IAG42_RS07570	COG3291	Pkd domain containing protein
IAG42_RS07580	COG0252	asparaginase activity
IAG42_RS07630	COG2040	homocysteine
IAG42_RS07665	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS07705	COG0175	sulfate reduction
IAG42_RS07710	COG0529	Catalyzes the synthesis of activated sulfate
IAG42_RS07735	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IAG42_RS07740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAG42_RS07770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IAG42_RS07775	COG0667	Aldo Keto reductase
IAG42_RS07890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IAG42_RS07895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAG42_RS07915	COG1357	PFAM Pentapeptide repeats (8 copies)
IAG42_RS07930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAG42_RS07935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IAG42_RS07965	COG2326	polyphosphate kinase activity
IAG42_RS07995	COG3220	belongs to the UPF0276 family
IAG42_RS08005	COG0596	Alpha beta hydrolase
IAG42_RS08010	COG3253	May function as heme-dependent peroxidase
IAG42_RS08015	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IAG42_RS08025	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAG42_RS08030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IAG42_RS08045	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IAG42_RS08060	COG0183	Belongs to the thiolase family
IAG42_RS08065	COG1024	Enoyl-CoA hydratase
IAG42_RS08065	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG42_RS08080	COG0531	amino acid
IAG42_RS08085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IAG42_RS08090	COG4214	carbohydrate transport
IAG42_RS08100	COG4213	ABC transporter substrate-binding protein
IAG42_RS08105	COG1940	carbohydrate kinase activity
IAG42_RS08110	COG0395	ABC-type sugar transport system, permease component
IAG42_RS08115	COG1175	transmembrane transport
IAG42_RS08120	COG1653	transport
IAG42_RS08135	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IAG42_RS08140	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IAG42_RS08155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IAG42_RS08200	COG1024	Enoyl-CoA hydratase
IAG42_RS08210	COG0531	amino acid
IAG42_RS08215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IAG42_RS08220	COG2235	arginine
IAG42_RS08225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IAG42_RS08260	COG1799	cell septum assembly
IAG42_RS08270	COG1136	(ABC) transporter
IAG42_RS08275	COG1119	ATPase activity
IAG42_RS08280	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IAG42_RS08285	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IAG42_RS08290	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IAG42_RS08300	COG0456	acetyltransferase
IAG42_RS08310	COG3250	beta-galactosidase activity
IAG42_RS08315	COG1609	Transcriptional regulator
IAG42_RS08345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IAG42_RS08350	COG0531	amino acid
IAG42_RS08355	COG0569	domain protein
IAG42_RS08385	COG0577	efflux transmembrane transporter activity
IAG42_RS08385	COG1136	(ABC) transporter
IAG42_RS08400	COG0756	dUTP diphosphatase activity
IAG42_RS08425	COG2205	protein histidine kinase activity
IAG42_RS08430	COG0745	RESPONSE REGULATOR receiver
IAG42_RS08440	COG0483	inositol monophosphate 1-phosphatase activity
IAG42_RS08445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IAG42_RS08480	COG1435	thymidine kinase activity
IAG42_RS08500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAG42_RS08505	COG1802	Transcriptional regulator
IAG42_RS08520	COG0612	Peptidase, M16
IAG42_RS08525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IAG42_RS08545	COG0372	Belongs to the citrate synthase family
IAG42_RS08560	COG3290	protein histidine kinase activity
IAG42_RS08565	COG4565	transcriptional regulatory protein
IAG42_RS08570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG42_RS08580	COG2197	response regulator
IAG42_RS08585	COG4585	Histidine kinase
IAG42_RS08610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IAG42_RS08615	COG1802	Transcriptional regulator
IAG42_RS08640	COG0514	ATP-dependent DNA helicase (RecQ)
IAG42_RS08655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IAG42_RS08690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IAG42_RS08695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IAG42_RS08700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IAG42_RS08740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IAG42_RS08750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IAG42_RS08755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IAG42_RS08765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IAG42_RS08785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAG42_RS08790	COG2358	TRAP transporter, solute receptor (TAXI family
IAG42_RS08795	COG2205	protein histidine kinase activity
IAG42_RS08800	COG0745	RESPONSE REGULATOR receiver
IAG42_RS08805	COG1126	abc transporter atp-binding protein
IAG42_RS08810	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IAG42_RS08815	COG0765	amino acid transport
IAG42_RS08820	COG0765	amino acid transport
IAG42_RS08825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAG42_RS08845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IAG42_RS08855	COG0628	permease
IAG42_RS08870	COG2508	Transcriptional regulator
IAG42_RS08885	COG2207	Transcriptional regulator
IAG42_RS08890	COG1201	RNA secondary structure unwinding
IAG42_RS08895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IAG42_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS08910	COG0783	Belongs to the Dps family
IAG42_RS08915	COG1396	sequence-specific DNA binding
IAG42_RS08920	COG1058	Belongs to the CinA family
IAG42_RS08920	COG1546	Belongs to the CinA family
IAG42_RS08930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAG42_RS08940	COG1674	ftsk spoiiie
IAG42_RS08955	COG2770	Histidine kinase
IAG42_RS08955	COG2208	phosphoserine phosphatase activity
IAG42_RS08985	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IAG42_RS08990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAG42_RS09010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IAG42_RS09015	COG0612	Peptidase, M16
IAG42_RS09020	COG1185	polyribonucleotide nucleotidyltransferase activity
IAG42_RS09025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IAG42_RS09035	COG1674	ftsk spoiiie
IAG42_RS09050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG42_RS09050	COG0515	serine threonine protein kinase
IAG42_RS09075	COG1404	Belongs to the peptidase S8 family
IAG42_RS09155	COG1404	Belongs to the peptidase S8 family
IAG42_RS09160	COG3266	domain, Protein
IAG42_RS09175	COG0455	bacterial-type flagellum organization
IAG42_RS09180	COG0747	negative chemotaxis
IAG42_RS09185	COG0601	transmembrane transport
IAG42_RS09190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG42_RS09195	COG0444	Belongs to the ABC transporter superfamily
IAG42_RS09200	COG4608	Belongs to the ABC transporter superfamily
IAG42_RS09220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IAG42_RS09225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IAG42_RS09235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IAG42_RS09250	COG0779	Required for maturation of 30S ribosomal subunits
IAG42_RS09275	COG0442	prolyl-tRNA aminoacylation
IAG42_RS09290	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IAG42_RS09295	COG0750	zinc metalloprotease
IAG42_RS09300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IAG42_RS09320	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS09325	COG2508	Transcriptional regulator
IAG42_RS09365	COG0583	DNA-binding transcription factor activity
IAG42_RS09375	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS09395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAG42_RS09400	COG1177	transmembrane transport
IAG42_RS09405	COG1176	ABC-type spermidine putrescine transport system, permease component I
IAG42_RS09410	COG3842	ATPase activity
IAG42_RS09420	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS09435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IAG42_RS09440	COG0584	glycerophosphoryl diester phosphodiesterase
IAG42_RS09460	COG0667	Aldo Keto reductase
IAG42_RS09475	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS09485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IAG42_RS09490	COG1136	(ABC) transporter
IAG42_RS09520	COG3842	ATPase activity
IAG42_RS09535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IAG42_RS09540	COG0575	Belongs to the CDS family
IAG42_RS09545	COG0233	cytoplasmic translational termination
IAG42_RS09550	COG0528	UMP kinase activity
IAG42_RS09555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IAG42_RS09560	COG0052	Belongs to the universal ribosomal protein uS2 family
IAG42_RS09575	COG1191	sigma factor activity
IAG42_RS09590	COG0792	nuclease activity
IAG42_RS09605	COG0681	Belongs to the peptidase S26 family
IAG42_RS09610	COG0681	Belongs to the peptidase S26 family
IAG42_RS09615	COG0681	Belongs to the peptidase S26 family
IAG42_RS09620	COG0681	Belongs to the peptidase S26 family
IAG42_RS09625	COG0335	large ribosomal subunit rRNA binding
IAG42_RS09630	COG0336	Belongs to the RNA methyltransferase TrmD family
IAG42_RS09635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IAG42_RS09640	COG1837	Belongs to the UPF0109 family
IAG42_RS09645	COG0228	four-way junction DNA binding
IAG42_RS09655	COG0442	prolyl-tRNA aminoacylation
IAG42_RS09665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IAG42_RS09675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IAG42_RS09720	COG0477	Major facilitator Superfamily
IAG42_RS09725	COG1196	nuclear chromosome segregation
IAG42_RS09735	COG1254	Belongs to the acylphosphatase family
IAG42_RS09740	COG2340	Cysteine-rich secretory protein family
IAG42_RS09745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IAG42_RS09750	COG0571	ribonuclease III activity
IAG42_RS09755	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IAG42_RS09770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IAG42_RS09775	COG0742	ribosomal rna small subunit methyltransferase
IAG42_RS09780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IAG42_RS09785	COG0326	Molecular chaperone. Has ATPase activity
IAG42_RS09795	COG1461	Dihydroxyacetone kinase
IAG42_RS09800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IAG42_RS09815	COG0351	phosphomethylpyrimidine kinase
IAG42_RS09835	COG1181	Belongs to the D-alanine--D-alanine ligase family
IAG42_RS09840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IAG42_RS09850	COG1920	GTP binding
IAG42_RS09860	COG0776	regulation of translation
IAG42_RS09870	COG0066	3-isopropylmalate dehydratase activity
IAG42_RS09875	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IAG42_RS09880	COG1414	Transcriptional regulator
IAG42_RS09915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IAG42_RS09920	COG0179	Fumarylacetoacetate (FAA) hydrolase
IAG42_RS09930	COG5002	protein histidine kinase activity
IAG42_RS09935	COG2018	Roadblock/LC7 domain
IAG42_RS09955	COG2018	Roadblock/LC7 domain
IAG42_RS09970	COG0515	serine threonine protein kinase
IAG42_RS09970	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG42_RS09985	COG4245	von Willebrand factor, type A
IAG42_RS10005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG42_RS10035	COG1470	cell adhesion involved in biofilm formation
IAG42_RS10035	COG0366	Alpha amylase catalytic
IAG42_RS10045	COG1132	(ABC) transporter
IAG42_RS10080	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IAG42_RS10090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IAG42_RS10100	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IAG42_RS10115	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IAG42_RS10120	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IAG42_RS10140	COG2957	Belongs to the agmatine deiminase family
IAG42_RS10145	COG0804	urea catabolic process
IAG42_RS10150	COG0831	urea catabolic process
IAG42_RS10150	COG0832	Belongs to the urease beta subunit family
IAG42_RS10155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IAG42_RS10160	COG0473	3-isopropylmalate dehydrogenase activity
IAG42_RS10175	COG0583	DNA-binding transcription factor activity
IAG42_RS10180	COG2130	NADP-dependent
IAG42_RS10215	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS10220	COG0506	proline dehydrogenase activity
IAG42_RS10225	COG2508	Transcriptional regulator
IAG42_RS10235	COG0477	Major facilitator Superfamily
IAG42_RS10240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAG42_RS10245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IAG42_RS10250	COG0440	acetolactate synthase activity
IAG42_RS10270	COG0667	Aldo Keto reductase
IAG42_RS10275	COG2133	pyrroloquinoline quinone binding
IAG42_RS10285	COG2197	response regulator
IAG42_RS10305	COG2409	Drug exporters of the RND superfamily
IAG42_RS10315	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IAG42_RS10320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IAG42_RS10330	COG0154	amidase activity
IAG42_RS10335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IAG42_RS10350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IAG42_RS10360	COG4221	oxidoreductase activity
IAG42_RS10365	COG1611	Belongs to the LOG family
IAG42_RS10395	COG0482	sulfurtransferase activity
IAG42_RS10420	COG1309	transcriptional regulator
IAG42_RS10425	COG2378	regulation of single-species biofilm formation
IAG42_RS10440	COG2860	membrane
IAG42_RS10445	COG4608	Belongs to the ABC transporter superfamily
IAG42_RS10450	COG0444	Belongs to the ABC transporter superfamily
IAG42_RS10460	COG4166	transmembrane transport
IAG42_RS10465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG42_RS10485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IAG42_RS10490	COG0509	glycine decarboxylation via glycine cleavage system
IAG42_RS10495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IAG42_RS10500	COG1760	l-serine dehydratase
IAG42_RS10505	COG0006	proline dipeptidase activity
IAG42_RS10545	COG0789	Transcriptional regulator
IAG42_RS10555	COG0726	polysaccharide deacetylase
IAG42_RS10570	COG1376	ErfK ybiS ycfS ynhG family protein
IAG42_RS10595	COG2197	response regulator
IAG42_RS10600	COG4585	Histidine kinase
IAG42_RS10610	COG1131	(ABC) transporter
IAG42_RS10615	COG1132	(ABC) transporter
IAG42_RS10620	COG1132	(ABC) transporter
IAG42_RS10635	COG0058	SHG alpha-glucan phosphorylase activity
IAG42_RS10640	COG0515	serine threonine protein kinase
IAG42_RS10640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG42_RS10645	COG0515	serine threonine protein kinase
IAG42_RS10645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG42_RS10665	COG0366	Alpha amylase catalytic
IAG42_RS10675	COG3281	Trehalose synthase
IAG42_RS10680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IAG42_RS10690	COG3118	belongs to the thioredoxin family
IAG42_RS10700	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IAG42_RS10720	COG0477	Major facilitator Superfamily
IAG42_RS10745	COG1301	dicarboxylic acid transport
IAG42_RS10750	COG3290	protein histidine kinase activity
IAG42_RS10755	COG4565	transcriptional regulatory protein
IAG42_RS10770	COG0205	6-phosphofructokinase activity
IAG42_RS10775	COG0857	belongs to the CobB CobQ family
IAG42_RS10775	COG0280	phosphate acetyltransferase
IAG42_RS10780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IAG42_RS10815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG42_RS10815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG42_RS10890	COG0745	RESPONSE REGULATOR receiver
IAG42_RS10905	COG0183	Belongs to the thiolase family
IAG42_RS10970	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IAG42_RS10985	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG42_RS11020	COG2197	response regulator
IAG42_RS11035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IAG42_RS11040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IAG42_RS11045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IAG42_RS11050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IAG42_RS11055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IAG42_RS11060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IAG42_RS11065	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IAG42_RS11090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IAG42_RS11095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAG42_RS11105	COG2890	protein-(glutamine-N5) methyltransferase activity
IAG42_RS11110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IAG42_RS11115	COG0254	rRNA binding
IAG42_RS11130	COG0083	homoserine kinase activity
IAG42_RS11135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IAG42_RS11140	COG0460	homoserine dehydrogenase
IAG42_RS11145	COG0019	diaminopimelate decarboxylase activity
IAG42_RS11150	COG0018	arginyl-trna synthetase
IAG42_RS11165	COG3594	Acyltransferase
IAG42_RS11170	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IAG42_RS11200	COG2205	protein histidine kinase activity
IAG42_RS11215	COG0768	penicillin binding
IAG42_RS11235	COG1309	transcriptional regulator
IAG42_RS11270	COG0791	NLP P60 protein
IAG42_RS11325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IAG42_RS11350	COG0745	RESPONSE REGULATOR receiver
IAG42_RS11355	COG2205	protein histidine kinase activity
IAG42_RS11360	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAG42_RS11360	COG0567	Dehydrogenase, E1 component
IAG42_RS11430	COG0604	alcohol dehydrogenase
IAG42_RS11435	COG0281	malic enzyme
IAG42_RS11445	COG0765	amino acid transport
IAG42_RS11450	COG1126	abc transporter atp-binding protein
IAG42_RS11455	COG4106	trans-aconitate 2-methyltransferase activity
IAG42_RS11505	COG0142	geranyltranstransferase activity
IAG42_RS11510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IAG42_RS11525	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IAG42_RS11540	COG2172	sigma factor antagonist activity
IAG42_RS11555	COG1597	lipid kinase activity
IAG42_RS11570	COG0363	glucosamine-6-phosphate deaminase activity
IAG42_RS11575	COG1472	Belongs to the glycosyl hydrolase 3 family
IAG42_RS11580	COG0395	ABC-type sugar transport system, permease component
IAG42_RS11585	COG1175	transmembrane transport
IAG42_RS11590	COG2182	Extracellular solute-binding protein
IAG42_RS11595	COG2188	Transcriptional regulator
IAG42_RS11620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IAG42_RS11635	COG2124	cytochrome p450
IAG42_RS11645	COG0242	peptide deformylase activity
IAG42_RS11660	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IAG42_RS11660	COG2199	diguanylate cyclase activity
IAG42_RS11665	COG5662	AntiSigma factor
IAG42_RS11670	COG1595	DNA-templated transcription, initiation
IAG42_RS11680	COG2135	peptidase activity
IAG42_RS11690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IAG42_RS11695	COG1162	GTPase activity
IAG42_RS11700	COG2076	Multidrug Resistance protein
IAG42_RS11710	COG0483	inositol monophosphate 1-phosphatase activity
IAG42_RS11720	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IAG42_RS11760	COG1615	UPF0182 protein
IAG42_RS11770	COG3480	Lon protease (S16) C-terminal proteolytic domain
IAG42_RS11825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IAG42_RS11860	COG2816	NAD+ diphosphatase activity
IAG42_RS11865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAG42_RS11870	COG0210	DNA helicase
IAG42_RS11925	COG0596	Alpha beta hydrolase
IAG42_RS11960	COG2267	carboxylic ester hydrolase activity
IAG42_RS11970	COG2095	MarC family integral membrane protein
IAG42_RS11985	COG2814	Major facilitator Superfamily
IAG42_RS11995	COG0598	Magnesium transport protein CorA
IAG42_RS12030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IAG42_RS12035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAG42_RS12045	COG1595	DNA-templated transcription, initiation
IAG42_RS12060	COG1024	Enoyl-CoA hydratase
IAG42_RS12065	COG0519	Catalyzes the synthesis of GMP from XMP
IAG42_RS12075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IAG42_RS12085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAG42_RS12125	COG2197	response regulator
IAG42_RS12130	COG4585	Histidine kinase
IAG42_RS12140	COG1131	(ABC) transporter
IAG42_RS12155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IAG42_RS12170	COG4608	Belongs to the ABC transporter superfamily
IAG42_RS12175	COG0444	Belongs to the ABC transporter superfamily
IAG42_RS12180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG42_RS12185	COG0601	transmembrane transport
IAG42_RS12200	COG4608	Belongs to the ABC transporter superfamily
IAG42_RS12205	COG0444	Belongs to the ABC transporter superfamily
IAG42_RS12210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG42_RS12225	COG1217	gtp-binding protein TYPA
IAG42_RS12245	COG1053	succinate dehydrogenase
IAG42_RS12260	COG0137	argininosuccinate synthase activity
IAG42_RS12270	COG1842	Phage shock protein A
IAG42_RS12315	COG2318	DinB family
IAG42_RS12325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IAG42_RS12335	COG0183	Belongs to the thiolase family
IAG42_RS12345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG42_RS12360	COG3485	protocatechuate 3,4-dioxygenase
IAG42_RS12365	COG3485	protocatechuate 3,4-dioxygenase
IAG42_RS12370	COG1414	Transcriptional regulator
IAG42_RS12390	COG1201	RNA secondary structure unwinding
IAG42_RS12445	COG0455	bacterial-type flagellum organization
IAG42_RS12460	COG0012	GTP binding
IAG42_RS12475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IAG42_RS12485	COG1570	exodeoxyribonuclease VII activity
IAG42_RS12490	COG1722	exodeoxyribonuclease VII activity
IAG42_RS12495	COG0778	Nitroreductase
IAG42_RS12520	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IAG42_RS12520	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IAG42_RS12530	COG0114	fumarate hydratase activity
IAG42_RS12555	COG2814	Major facilitator Superfamily
IAG42_RS12565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAG42_RS12600	COG0450	alkyl hydroperoxide reductase
IAG42_RS12605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG42_RS12615	COG0741	lytic transglycosylase activity
IAG42_RS12620	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IAG42_RS12625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IAG42_RS12630	COG0667	Aldo Keto reductase
IAG42_RS12635	COG2124	cytochrome p450
IAG42_RS12660	COG0515	serine threonine protein kinase
IAG42_RS12660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG42_RS12665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IAG42_RS12690	COG0596	Alpha beta hydrolase
IAG42_RS12700	COG2885	chlorophyll binding
IAG42_RS12740	COG2894	cell division
IAG42_RS12790	COG2610	gluconate transmembrane transporter activity
IAG42_RS12795	COG0251	oxidation-reduction process
IAG42_RS12800	COG1414	Transcriptional regulator
IAG42_RS12815	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IAG42_RS12855	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IAG42_RS12865	COG0477	Major facilitator Superfamily
IAG42_RS12870	COG1309	transcriptional regulator
IAG42_RS12895	COG1331	Highly conserved protein containing a thioredoxin domain
IAG42_RS12925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IAG42_RS12935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IAG42_RS12950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IAG42_RS12955	COG2255	four-way junction helicase activity
IAG42_RS12975	COG0501	Belongs to the peptidase M48B family
IAG42_RS12990	COG1064	alcohol dehydrogenase
IAG42_RS13010	COG1316	TRANSCRIPTIONal
IAG42_RS13015	COG1216	Glycosyl transferase, family 2
IAG42_RS13020	COG1136	(ABC) transporter
IAG42_RS13030	COG1376	ErfK ybiS ycfS ynhG family protein
IAG42_RS13050	COG1024	Enoyl-CoA hydratase
IAG42_RS13055	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IAG42_RS13065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG42_RS13075	COG0424	maF-like protein
IAG42_RS13085	COG4770	biotin carboxylase activity
IAG42_RS13115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAG42_RS13130	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IAG42_RS13135	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS13140	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS13170	COG1595	DNA-templated transcription, initiation
IAG42_RS13175	COG0745	RESPONSE REGULATOR receiver
IAG42_RS13180	COG2205	protein histidine kinase activity
IAG42_RS13205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IAG42_RS13220	COG0583	DNA-binding transcription factor activity
IAG42_RS13225	COG2814	Major facilitator Superfamily
IAG42_RS13260	COG4603	Belongs to the binding-protein-dependent transport system permease family
IAG42_RS13265	COG3845	ABC transporter
IAG42_RS13270	COG1744	ABC transporter substrate-binding protein PnrA-like
IAG42_RS13275	COG1744	ABC transporter substrate-binding protein PnrA-like
IAG42_RS13280	COG1473	amidohydrolase
IAG42_RS13280	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IAG42_RS13295	COG2089	acid synthase
IAG42_RS13300	COG1083	cytidylyl-transferase
IAG42_RS13310	COG1216	Glycosyl transferase, family 2
IAG42_RS13340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG42_RS13340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG42_RS13355	COG1595	DNA-templated transcription, initiation
IAG42_RS13365	COG1595	DNA-templated transcription, initiation
IAG42_RS13405	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IAG42_RS13415	COG2009	succinate dehydrogenase
IAG42_RS13425	COG1053	succinate dehydrogenase
IAG42_RS13465	COG1686	Belongs to the peptidase S11 family
IAG42_RS13475	COG1408	metallophosphoesterase
IAG42_RS13480	COG1686	Belongs to the peptidase S11 family
IAG42_RS13485	COG1295	ribonuclease BN
IAG42_RS13500	COG0671	phosphoesterase, PA-phosphatase related
IAG42_RS13520	COG0180	Tryptophanyl-tRNA synthetase
IAG42_RS13525	COG1595	DNA-templated transcription, initiation
IAG42_RS13540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IAG42_RS13545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAG42_RS13550	COG0754	glutathionylspermidine amidase activity
IAG42_RS13565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAG42_RS13570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG42_RS13575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG42_RS13590	COG4176	ABC-type proline glycine betaine transport system permease component
IAG42_RS13595	COG4175	Glycine betaine
IAG42_RS13595	COG0517	IMP dehydrogenase activity
IAG42_RS13605	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS13630	COG0039	L-malate dehydrogenase activity
IAG42_RS13645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IAG42_RS13665	COG0138	bifunctional purine biosynthesis protein purh
IAG42_RS13695	COG0045	succinate-CoA ligase (ADP-forming) activity
IAG42_RS13710	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IAG42_RS13715	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IAG42_RS13720	COG0714	Associated with various cellular activities
IAG42_RS13735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAG42_RS13775	COG1595	DNA-templated transcription, initiation
IAG42_RS13810	COG2197	response regulator
IAG42_RS13845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IAG42_RS13845	COG0519	Catalyzes the synthesis of GMP from XMP
IAG42_RS13855	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS13870	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS13880	COG0515	serine threonine protein kinase
IAG42_RS13885	COG0515	serine threonine protein kinase
IAG42_RS13890	COG0515	serine threonine protein kinase
IAG42_RS13910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IAG42_RS13925	COG0516	GMP reductase activity
IAG42_RS13935	COG1595	DNA-templated transcription, initiation
IAG42_RS13950	COG0583	DNA-binding transcription factor activity
IAG42_RS13960	COG2132	Multicopper oxidase
IAG42_RS13965	COG4221	oxidoreductase activity
IAG42_RS13975	COG0459	protein refolding
IAG42_RS13985	COG0726	polysaccharide deacetylase
IAG42_RS13990	COG0726	polysaccharide deacetylase
IAG42_RS14000	COG4941	Belongs to the sigma-70 factor family
IAG42_RS14015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IAG42_RS14025	COG1214	PFAM Peptidase M22, glycoprotease
IAG42_RS14025	COG0456	acetyltransferase
IAG42_RS14035	COG0802	atpase or kinase
IAG42_RS14045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IAG42_RS14065	COG0596	Alpha beta hydrolase
IAG42_RS14070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IAG42_RS14070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IAG42_RS14075	COG0736	holo-[acyl-carrier-protein] synthase activity
IAG42_RS14080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IAG42_RS14085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IAG42_RS14095	COG1072	(Pantothenic acid kinase))
IAG42_RS14105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAG42_RS14110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAG42_RS14115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IAG42_RS14135	COG1215	transferase activity, transferring glycosyl groups
IAG42_RS14140	COG0101	tRNA pseudouridine synthase activity
IAG42_RS14150	COG0203	ribosomal protein L17
IAG42_RS14155	COG0202	RNA polymerase activity
IAG42_RS14160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IAG42_RS14165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IAG42_RS14170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IAG42_RS14175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IAG42_RS14185	COG0563	adenylate kinase activity
IAG42_RS14195	COG0200	Binds to the 23S rRNA
IAG42_RS14200	COG1841	ribosomal large subunit assembly
IAG42_RS14205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IAG42_RS14210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IAG42_RS14215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IAG42_RS14220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IAG42_RS14225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IAG42_RS14230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IAG42_RS14235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IAG42_RS14240	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IAG42_RS14245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IAG42_RS14250	COG0255	Belongs to the universal ribosomal protein uL29 family
IAG42_RS14255	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IAG42_RS14260	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IAG42_RS14265	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IAG42_RS14270	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IAG42_RS14275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IAG42_RS14280	COG0089	rRNA binding
IAG42_RS14285	COG0088	Forms part of the polypeptide exit tunnel
IAG42_RS14290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IAG42_RS14295	COG0051	transcription antitermination factor activity, RNA binding
IAG42_RS14305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAG42_RS14310	COG1397	ADP-ribosylglycohydrolase
IAG42_RS14335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IAG42_RS14340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IAG42_RS14345	COG0049	tRNA binding
IAG42_RS14350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IAG42_RS14360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IAG42_RS14365	COG0085	RNA polymerase activity
IAG42_RS14370	COG0222	ribosome binding
IAG42_RS14375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IAG42_RS14390	COG0081	regulation of translation
IAG42_RS14395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IAG42_RS14405	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IAG42_RS14415	COG0436	Aminotransferase
IAG42_RS14420	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IAG42_RS14430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAG42_RS14440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IAG42_RS14450	COG0477	Major facilitator Superfamily
IAG42_RS14465	COG2030	dehydratase
IAG42_RS14470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IAG42_RS14485	COG0402	S-adenosylhomocysteine deaminase activity
IAG42_RS14520	COG1666	GTP binding
IAG42_RS14525	COG2261	transglycosylase associated protein
IAG42_RS14530	COG3304	Inner membrane component domain
IAG42_RS14535	COG0501	Belongs to the peptidase M48B family
IAG42_RS14540	COG1970	mechanosensitive ion channel activity
IAG42_RS14545	COG1007	ATP synthesis coupled electron transport
IAG42_RS14560	COG0713	ATP synthesis coupled electron transport
IAG42_RS14565	COG0839	Belongs to the complex I subunit 6 family
IAG42_RS14570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG42_RS14575	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IAG42_RS14580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG42_RS14585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG42_RS14590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG42_RS14595	COG4585	Histidine kinase
IAG42_RS14610	COG0674	pyruvate-flavodoxin oxidoreductase activity
IAG42_RS14610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IAG42_RS14615	COG1013	pyruvate-flavodoxin oxidoreductase activity
IAG42_RS14645	COG1131	(ABC) transporter
IAG42_RS14655	COG0142	geranyltranstransferase activity
IAG42_RS14665	COG0561	phosphatase activity
IAG42_RS14680	COG3209	COG3209 Rhs family protein
IAG42_RS14690	COG0514	ATP-dependent DNA helicase (RecQ)
IAG42_RS14695	COG1007	ATP synthesis coupled electron transport
IAG42_RS14705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IAG42_RS14710	COG0713	ATP synthesis coupled electron transport
IAG42_RS14715	COG0839	Belongs to the complex I subunit 6 family
IAG42_RS14720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG42_RS14725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IAG42_RS14730	COG1034	ATP synthesis coupled electron transport
IAG42_RS14735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IAG42_RS14745	COG0649	NAD binding
IAG42_RS14750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG42_RS14755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAG42_RS14790	COG2226	methyltransferase
IAG42_RS14800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IAG42_RS14820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IAG42_RS14825	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IAG42_RS14830	COG1278	Cold shock
IAG42_RS14835	COG1396	sequence-specific DNA binding
IAG42_RS14870	COG0183	Belongs to the thiolase family
IAG42_RS14885	COG1309	transcriptional regulator
IAG42_RS14890	COG1301	dicarboxylic acid transport
IAG42_RS14905	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IAG42_RS14915	COG0163	prenyltransferase activity
IAG42_RS14955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IAG42_RS14960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IAG42_RS14985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IAG42_RS14990	COG1333	cytochrome c biogenesis protein
IAG42_RS14995	COG0785	Cytochrome C biogenesis protein
IAG42_RS15000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAG42_RS15010	COG0406	alpha-ribazole phosphatase activity
IAG42_RS15015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IAG42_RS15025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS15030	COG2205	protein histidine kinase activity
IAG42_RS15030	COG2972	Histidine kinase
IAG42_RS15035	COG0745	RESPONSE REGULATOR receiver
IAG42_RS15040	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS15050	COG0431	NADPH-dependent FMN reductase
IAG42_RS15080	COG1742	UPF0060 membrane protein
IAG42_RS15090	COG1846	Transcriptional regulator
IAG42_RS15100	COG1690	Belongs to the RtcB family
IAG42_RS15120	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IAG42_RS15125	COG0018	arginyl-trna synthetase
IAG42_RS15135	COG1072	(Pantothenic acid kinase))
IAG42_RS15140	COG0515	serine threonine protein kinase
IAG42_RS15140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG42_RS15160	COG1024	Enoyl-CoA hydratase
IAG42_RS15170	COG0515	serine threonine protein kinase
IAG42_RS15170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG42_RS15180	COG1309	transcriptional regulator
IAG42_RS15190	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS15195	COG0183	Belongs to the thiolase family
IAG42_RS15220	COG2072	flavoprotein involved in K transport
IAG42_RS15225	COG0596	Alpha beta hydrolase
IAG42_RS15230	COG1846	Transcriptional regulator
IAG42_RS15240	COG1024	Enoyl-CoA hydratase
IAG42_RS15250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IAG42_RS15255	COG2910	NAD(P)H-binding
IAG42_RS15265	COG2814	Major facilitator Superfamily
IAG42_RS15280	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IAG42_RS15285	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS15290	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS15305	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS15310	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS15320	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS15335	COG1595	DNA-templated transcription, initiation
IAG42_RS15375	COG1131	(ABC) transporter
IAG42_RS15390	COG4821	SIS domain
IAG42_RS15400	COG2945	thiolester hydrolase activity
IAG42_RS15400	COG0596	Alpha beta hydrolase
IAG42_RS15405	COG0259	pyridoxamine-phosphate oxidase activity
IAG42_RS15445	COG1316	TRANSCRIPTIONal
IAG42_RS15480	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS15490	COG0728	peptidoglycan biosynthetic process
IAG42_RS15500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IAG42_RS15505	COG0297	glycogen (starch) synthase activity
IAG42_RS15580	COG1024	Enoyl-CoA hydratase
IAG42_RS15585	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS15600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG42_RS15615	COG5006	permease, DMT superfamily
IAG42_RS15620	COG0583	DNA-binding transcription factor activity
IAG42_RS15625	COG0277	FAD linked oxidase domain protein
IAG42_RS15625	COG0247	lactate metabolic process
IAG42_RS15660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IAG42_RS15680	COG0667	Aldo Keto reductase
IAG42_RS15710	COG2252	PERMEase
IAG42_RS15720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IAG42_RS15740	COG2814	Major facilitator Superfamily
IAG42_RS15750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IAG42_RS15755	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IAG42_RS15780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG42_RS15785	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG42_RS15790	COG1120	ATPase activity
IAG42_RS15795	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IAG42_RS15810	COG1061	Type III restriction enzyme res subunit
IAG42_RS15825	COG3142	Participates in the control of copper homeostasis
IAG42_RS15830	COG3973	AAA domain
IAG42_RS15835	COG1280	lysine exporter protein (LysE YggA)
IAG42_RS15865	COG1737	Transcriptional regulator
IAG42_RS15870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IAG42_RS15890	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IAG42_RS15900	COG3851	Histidine kinase
IAG42_RS15905	COG2197	response regulator
IAG42_RS15925	COG1278	Cold shock
IAG42_RS15940	COG0463	Glycosyl transferase, family 2
IAG42_RS15945	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IAG42_RS15960	COG1653	transport
IAG42_RS16010	COG4978	Transcriptional regulator
IAG42_RS16010	COG0789	Transcriptional regulator
IAG42_RS16050	COG0666	response to abiotic stimulus
IAG42_RS16065	COG2197	response regulator
IAG42_RS16115	COG3842	ATPase activity
IAG42_RS16125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IAG42_RS16135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IAG42_RS16140	COG0215	cysteine-tRNA ligase activity
IAG42_RS16145	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IAG42_RS16150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IAG42_RS16155	COG1329	Transcriptional regulator
IAG42_RS16170	COG5002	protein histidine kinase activity
IAG42_RS16200	COG0588	phosphoglycerate mutase activity
IAG42_RS16230	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS16270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG42_RS16275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IAG42_RS16280	COG3973	AAA domain
IAG42_RS16290	COG0510	thiamine kinase activity
IAG42_RS16300	COG2188	Transcriptional regulator
IAG42_RS16325	COG4552	Acetyltransferase involved in intracellular survival and related
IAG42_RS16335	COG1490	D-aminoacyl-tRNA deacylase activity
IAG42_RS16340	COG0354	folic acid binding
IAG42_RS16345	COG0735	belongs to the Fur family
IAG42_RS16350	COG3485	protocatechuate 3,4-dioxygenase
IAG42_RS16380	COG2897	thiosulfate sulfurtransferase activity
IAG42_RS16405	COG0745	RESPONSE REGULATOR receiver
IAG42_RS16410	COG1609	Transcriptional regulator
IAG42_RS16415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAG42_RS16425	COG0745	RESPONSE REGULATOR receiver
IAG42_RS16445	COG0456	acetyltransferase
IAG42_RS16450	COG1725	Transcriptional regulator
IAG42_RS16455	COG3842	ATPase activity
IAG42_RS16470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IAG42_RS16480	COG0406	alpha-ribazole phosphatase activity
IAG42_RS16480	COG0494	nUDIX hydrolase
IAG42_RS16500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IAG42_RS16505	COG0306	phosphate transporter
IAG42_RS16515	COG1937	Protein conserved in bacteria
IAG42_RS16535	COG0277	FAD linked oxidase domain protein
IAG42_RS16540	COG0671	phosphoesterase, PA-phosphatase related
IAG42_RS16545	COG0741	lytic transglycosylase activity
IAG42_RS16545	COG1196	nuclear chromosome segregation
IAG42_RS16545	COG0739	heme binding
IAG42_RS16665	COG1131	(ABC) transporter
IAG42_RS16675	COG4585	Histidine kinase
IAG42_RS16680	COG2197	response regulator
IAG42_RS16715	COG1252	NADH dehydrogenase
IAG42_RS16725	COG0366	Alpha amylase catalytic
IAG42_RS16725	COG1470	cell adhesion involved in biofilm formation
IAG42_RS16745	COG0579	oxidoreductase
IAG42_RS16750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IAG42_RS16760	COG0667	Aldo Keto reductase
IAG42_RS16850	COG0513	Belongs to the DEAD box helicase family
IAG42_RS16895	COG1643	Atp-dependent helicase
IAG42_RS16920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IAG42_RS16930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IAG42_RS16940	COG3119	arylsulfatase activity
IAG42_RS16965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IAG42_RS16970	COG0047	phosphoribosylformylglycinamidine synthase activity
IAG42_RS16975	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IAG42_RS16995	COG1131	(ABC) transporter
IAG42_RS17005	COG4585	Histidine kinase
IAG42_RS17010	COG2197	response regulator
IAG42_RS17020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IAG42_RS17035	COG0151	Belongs to the GarS family
IAG42_RS17085	COG0583	DNA-binding transcription factor activity
IAG42_RS17110	COG0433	COG0433 Predicted ATPase
IAG42_RS17125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IAG42_RS17160	COG1191	sigma factor activity
IAG42_RS17165	COG1191	sigma factor activity
IAG42_RS17190	COG2353	YceI-like domain
IAG42_RS17195	COG3467	pyridoxamine 5'-phosphate
IAG42_RS17205	COG0477	Major facilitator Superfamily
IAG42_RS17215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IAG42_RS17225	COG2205	protein histidine kinase activity
IAG42_RS17230	COG0745	RESPONSE REGULATOR receiver
IAG42_RS17240	COG2329	Antibiotic biosynthesis monooxygenase
IAG42_RS17250	COG1595	DNA-templated transcription, initiation
IAG42_RS17275	COG0784	Response regulator, receiver
IAG42_RS17280	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS17285	COG1595	DNA-templated transcription, initiation
IAG42_RS17300	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS17310	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS17345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAG42_RS17360	COG0653	protein targeting
IAG42_RS17380	COG0006	proline dipeptidase activity
IAG42_RS17400	COG1999	signal sequence binding
IAG42_RS17415	COG2837	iron assimilation
IAG42_RS17420	COG0077	Prephenate dehydratase
IAG42_RS17425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IAG42_RS17430	COG0561	phosphatase activity
IAG42_RS17480	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IAG42_RS17495	COG0561	phosphatase activity
IAG42_RS17500	COG0739	heme binding
IAG42_RS17510	COG4988	ABC transporter
IAG42_RS17515	COG1294	oxidase, subunit
IAG42_RS17520	COG1271	oxidase subunit
IAG42_RS17530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAG42_RS17535	COG1609	Transcriptional regulator
IAG42_RS17540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IAG42_RS17550	COG1733	regulation of RNA biosynthetic process
IAG42_RS17560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IAG42_RS17585	COG0662	Cupin 2, conserved barrel domain protein
IAG42_RS17590	COG1950	PFAM Membrane protein of
IAG42_RS17595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAG42_RS17645	COG0305	Participates in initiation and elongation during chromosome replication
IAG42_RS17655	COG0359	binds to the 23S rRNA
IAG42_RS17660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IAG42_RS17665	COG0629	single-stranded DNA binding
IAG42_RS17670	COG0360	Binds together with S18 to 16S ribosomal RNA
IAG42_RS17695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAG42_RS17705	COG1260	myo-inositol-1-phosphate synthase
IAG42_RS17715	COG0617	tRNA 3'-terminal CCA addition
IAG42_RS17735	COG1595	DNA-templated transcription, initiation
IAG42_RS17745	COG0492	ferredoxin-NADP+ reductase activity
IAG42_RS17750	COG3118	belongs to the thioredoxin family
IAG42_RS17765	COG1192	Involved in chromosome partitioning
IAG42_RS17770	COG0357	Ribosomal RNA small subunit methyltransferase G
IAG42_RS17780	COG0706	membrane insertase activity
IAG42_RS17785	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IAG42_RS17790	COG0594	ribonuclease P activity
IAG42_RS17795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IAG42_RS17800	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IAG42_RS17805	COG0592	DNA-directed DNA polymerase activity
IAG42_RS17810	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IAG42_RS17815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IAG42_RS17820	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IAG42_RS17825	COG0187	DNA topoisomerase II activity
IAG42_RS17830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IAG42_RS17860	COG0515	serine threonine protein kinase
IAG42_RS17875	COG0137	argininosuccinate synthase activity
IAG42_RS17915	COG0705	Rhomboid family
IAG42_RS17930	COG3764	Sortase (surface protein transpeptidase)
IAG42_RS17945	COG3764	Sortase (surface protein transpeptidase)
IAG42_RS17950	COG3764	Sortase (surface protein transpeptidase)
IAG42_RS17955	COG0515	serine threonine protein kinase
IAG42_RS17960	COG0768	penicillin binding
IAG42_RS17975	COG1716	ATPase activity
IAG42_RS17980	COG1716	ATPase activity
IAG42_RS17990	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IAG42_RS17995	COG1733	regulation of RNA biosynthetic process
IAG42_RS18020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IAG42_RS18025	COG2151	metal-sulfur cluster biosynthetic enzyme
IAG42_RS18030	COG3396	Phenylacetate-CoA oxygenase
IAG42_RS18035	COG3460	Phenylacetate-CoA oxygenase
IAG42_RS18040	COG3396	Phenylacetate-CoA oxygenase
IAG42_RS18065	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAG42_RS18070	COG1309	transcriptional regulator
IAG42_RS18075	COG1522	sequence-specific DNA binding
IAG42_RS18110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IAG42_RS18115	COG0604	alcohol dehydrogenase
IAG42_RS18135	COG0515	serine threonine protein kinase
IAG42_RS18140	COG0515	serine threonine protein kinase
IAG42_RS18160	COG0022	dehydrogenase e1 component
IAG42_RS18165	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAG42_RS18175	COG1802	Transcriptional regulator
IAG42_RS18180	COG2271	Major facilitator Superfamily
IAG42_RS18230	COG3903	Transcriptional regulator
IAG42_RS18230	COG3629	intracellular signal transduction
IAG42_RS18240	COG1362	aminopeptidase activity
IAG42_RS18245	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS18260	COG1741	Belongs to the pirin family
IAG42_RS18275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IAG42_RS18280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAG42_RS18290	COG0583	DNA-binding transcription factor activity
IAG42_RS18310	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS18320	COG1289	transmembrane transporter activity
IAG42_RS18360	COG1475	DNA binding
IAG42_RS18365	COG1192	Involved in chromosome partitioning
IAG42_RS18410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAG42_RS18435	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IAG42_RS18480	COG0569	domain protein
IAG42_RS18480	COG0475	glutathione-regulated potassium exporter activity
IAG42_RS18490	COG1216	Glycosyl transferase, family 2
IAG42_RS18515	COG2175	clavaminate synthase activity
IAG42_RS18530	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS18570	COG0531	amino acid
IAG42_RS18590	COG0717	Belongs to the dCTP deaminase family
IAG42_RS18620	COG2181	nitrate reductase activity
IAG42_RS18620	COG0247	lactate metabolic process
IAG42_RS18630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IAG42_RS18650	COG0443	Heat shock 70 kDa protein
IAG42_RS18655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IAG42_RS18660	COG0484	heat shock protein binding
IAG42_RS18665	COG0789	Transcriptional regulator
IAG42_RS18695	COG5297	Belongs to the glycosyl hydrolase family 6
IAG42_RS18695	COG4733	cellulase activity
IAG42_RS18710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAG42_RS18720	COG4213	ABC transporter substrate-binding protein
IAG42_RS18750	COG0542	response to heat
IAG42_RS18780	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IAG42_RS18795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IAG42_RS18800	COG0191	fructose-bisphosphate aldolase activity
IAG42_RS18805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IAG42_RS18820	COG3844	kynureninase activity
IAG42_RS18840	COG4585	Histidine kinase
IAG42_RS18845	COG2197	response regulator
IAG42_RS18855	COG1131	(ABC) transporter
IAG42_RS18860	COG3559	Exporter of polyketide antibiotics
IAG42_RS18870	COG2197	response regulator
IAG42_RS18875	COG4585	Histidine kinase
IAG42_RS18880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IAG42_RS18885	COG0515	serine threonine protein kinase
IAG42_RS18885	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG42_RS18900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IAG42_RS18915	COG0477	Major facilitator Superfamily
IAG42_RS18925	COG1802	Transcriptional regulator
IAG42_RS18935	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IAG42_RS18940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IAG42_RS18960	COG1595	DNA-templated transcription, initiation
IAG42_RS19020	COG0640	Transcriptional regulator
IAG42_RS19125	COG0656	L-ascorbic acid biosynthetic process
IAG42_RS19195	COG1609	Transcriptional regulator
IAG42_RS19210	COG1408	metallophosphoesterase
IAG42_RS19220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAG42_RS19220	COG4499	WXG100 protein secretion system (Wss), protein YukC
IAG42_RS19230	COG0003	Pfam Anion-transporting ATPase
IAG42_RS19255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAG42_RS19285	COG0596	Alpha beta hydrolase
IAG42_RS19295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IAG42_RS19300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAG42_RS19365	COG1111	helicase
IAG42_RS19365	COG1205	dead DEAH box helicase
IAG42_RS19370	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG42_RS19375	COG2172	sigma factor antagonist activity
IAG42_RS19380	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IAG42_RS19390	COG2890	protein-(glutamine-N5) methyltransferase activity
IAG42_RS19415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IAG42_RS19415	COG1754	DNA topoisomerase type I activity
IAG42_RS19420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IAG42_RS19450	COG2855	membrane
IAG42_RS19470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAG42_RS19470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAG42_RS19475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IAG42_RS19475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IAG42_RS19495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IAG42_RS19500	COG0254	rRNA binding
IAG42_RS19505	COG1012	belongs to the aldehyde dehydrogenase family
IAG42_RS19525	COG2318	DinB family
IAG42_RS19535	COG0076	glutamate decarboxylase activity
IAG42_RS19540	COG0789	Transcriptional regulator
IAG42_RS19545	COG0393	Putative heavy-metal-binding
IAG42_RS19560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IAG42_RS19565	COG2027	D-alanyl-D-alanine carboxypeptidase
IAG42_RS19575	COG0037	tRNA processing
IAG42_RS19590	COG0302	gtp cyclohydrolase
IAG42_RS19600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IAG42_RS19605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IAG42_RS19630	COG0517	IMP dehydrogenase activity
IAG42_RS19630	COG1125	glycine betaine transport
IAG42_RS19635	COG1174	glycine betaine transport
IAG42_RS19640	COG1174	glycine betaine transport
IAG42_RS19665	COG0649	NAD binding
IAG42_RS19680	COG2197	response regulator
IAG42_RS19685	COG1660	Displays ATPase and GTPase activities
IAG42_RS19710	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IAG42_RS19715	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IAG42_RS19725	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IAG42_RS19750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IAG42_RS19775	COG0739	heme binding
IAG42_RS19780	COG1309	transcriptional regulator
IAG42_RS19785	COG0477	Major facilitator Superfamily
IAG42_RS19790	COG2205	protein histidine kinase activity
IAG42_RS19795	COG0745	RESPONSE REGULATOR receiver
IAG42_RS19805	COG1595	DNA-templated transcription, initiation
IAG42_RS19810	COG1194	a g-specific adenine glycosylase
IAG42_RS19815	COG4585	Histidine kinase
IAG42_RS19840	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IAG42_RS19860	COG0248	Ppx GppA phosphatase
IAG42_RS19865	COG1082	Xylose isomerase domain protein TIM barrel
IAG42_RS19875	COG0129	dihydroxy-acid dehydratase activity
IAG42_RS19885	COG0842	Transport permease protein
IAG42_RS19885	COG1129	ABC transporter
IAG42_RS19895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IAG42_RS19925	COG0123	including yeast histone deacetylase and acetoin utilization protein
IAG42_RS19975	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IAG42_RS19980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IAG42_RS19985	COG0181	hydroxymethylbilane synthase activity
IAG42_RS19990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IAG42_RS19990	COG1648	precorrin-2 dehydrogenase activity
IAG42_RS19995	COG0113	porphobilinogen synthase activity
IAG42_RS20050	COG3629	intracellular signal transduction
IAG42_RS20050	COG3903	Transcriptional regulator
IAG42_RS20060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAG42_RS20060	COG0515	serine threonine protein kinase
IAG42_RS20105	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IAG42_RS20155	COG1686	Belongs to the peptidase S11 family
IAG42_RS20185	COG0800	Aldolase
IAG42_RS20195	COG0405	Gamma-glutamyltransferase
IAG42_RS20225	COG1733	regulation of RNA biosynthetic process
IAG42_RS20290	COG1846	Transcriptional regulator
IAG42_RS20295	COG3384	dioxygenase
IAG42_RS20305	COG1247	-acetyltransferase
IAG42_RS20310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IAG42_RS20320	COG0477	Major facilitator Superfamily
IAG42_RS20325	COG1653	transport
IAG42_RS20350	COG1376	ErfK ybiS ycfS ynhG family protein
IAG42_RS20355	COG3191	aminopeptidase activity
IAG42_RS20365	COG1970	mechanosensitive ion channel activity
IAG42_RS20375	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IAG42_RS20390	COG3263	regulation of cellular component size
IAG42_RS20395	COG2366	antibiotic biosynthetic process
IAG42_RS20400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IAG42_RS20405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IAG42_RS20415	COG0315	cyclic pyranopterin monophosphate synthase activity
IAG42_RS20420	COG0315	cyclic pyranopterin monophosphate synthase activity
IAG42_RS20420	COG0521	Mo-molybdopterin cofactor biosynthetic process
IAG42_RS20425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAG42_RS20455	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS20460	COG2267	carboxylic ester hydrolase activity
IAG42_RS20465	COG2072	flavoprotein involved in K transport
IAG42_RS20475	COG4946	Tricorn protease homolog
IAG42_RS20475	COG0793	Belongs to the peptidase S41A family
IAG42_RS20485	COG2409	Drug exporters of the RND superfamily
IAG42_RS20495	COG0310	cobalt ion transport
IAG42_RS20505	COG1122	ATPase activity
IAG42_RS20510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAG42_RS20530	COG0442	prolyl-tRNA aminoacylation
IAG42_RS20560	COG0084	hydrolase, TatD family'
IAG42_RS20565	COG3583	domain protein
IAG42_RS20565	COG3584	3D domain protein
IAG42_RS20570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IAG42_RS20575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IAG42_RS20580	COG0488	(ABC) transporter
IAG42_RS20620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IAG42_RS20630	COG2197	response regulator
IAG42_RS20645	COG4106	trans-aconitate 2-methyltransferase activity
IAG42_RS20655	COG1309	transcriptional regulator
IAG42_RS20665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IAG42_RS20675	COG0193	aminoacyl-tRNA hydrolase activity
IAG42_RS20680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IAG42_RS20685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IAG42_RS20690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IAG42_RS20700	COG4585	Histidine kinase
IAG42_RS20725	COG1316	TRANSCRIPTIONal
IAG42_RS20740	COG0242	peptide deformylase activity
IAG42_RS20750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG42_RS20760	COG2814	Major facilitator Superfamily
IAG42_RS20765	COG1136	(ABC) transporter
IAG42_RS20770	COG0577	efflux transmembrane transporter activity
IAG42_RS20820	COG2815	serine threonine protein kinase
IAG42_RS20820	COG0515	serine threonine protein kinase
IAG42_RS20840	COG2124	cytochrome p450
IAG42_RS20860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAG42_RS20865	COG1652	LysM domain
IAG42_RS20875	COG0148	phosphopyruvate hydratase activity
IAG42_RS20895	COG1252	NADH dehydrogenase
IAG42_RS20900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IAG42_RS20905	COG0577	efflux transmembrane transporter activity
IAG42_RS20910	COG1136	(ABC) transporter
IAG42_RS20940	COG0183	Belongs to the thiolase family
IAG42_RS20945	COG2755	lipolytic protein G-D-S-L family
IAG42_RS20980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IAG42_RS21015	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IAG42_RS21020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAG42_RS21030	COG1228	amidohydrolase
IAG42_RS21035	COG1191	sigma factor activity
IAG42_RS21040	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG42_RS21075	COG3104	oligopeptide transport
IAG42_RS21080	COG0745	RESPONSE REGULATOR receiver
IAG42_RS21085	COG2205	protein histidine kinase activity
IAG42_RS21120	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IAG42_RS21155	COG1316	TRANSCRIPTIONal
IAG42_RS21160	COG1607	acyl-coa hydrolase
IAG42_RS21165	COG1316	TRANSCRIPTIONal
IAG42_RS21180	COG1316	TRANSCRIPTIONal
IAG42_RS21185	COG1316	TRANSCRIPTIONal
IAG42_RS21210	COG0778	Nitroreductase
IAG42_RS21210	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IAG42_RS21215	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IAG42_RS21250	COG1620	l-lactate permease
IAG42_RS21260	COG2835	tetraacyldisaccharide 4'-kinase activity
IAG42_RS21270	COG1482	cell wall glycoprotein biosynthetic process
IAG42_RS21285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IAG42_RS21325	COG0714	Associated with various cellular activities
IAG42_RS21345	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IAG42_RS21350	COG0745	RESPONSE REGULATOR receiver
IAG42_RS21355	COG5000	phosphorelay sensor kinase activity
IAG42_RS21355	COG5002	protein histidine kinase activity
IAG42_RS21360	COG0823	Involved in the tonB-independent uptake of proteins
IAG42_RS21370	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IAG42_RS21375	COG2197	response regulator
IAG42_RS21380	COG3214	Protein conserved in bacteria
IAG42_RS21390	COG0653	protein targeting
IAG42_RS21420	COG2902	Dehydrogenase
IAG42_RS21425	COG1216	Glycosyl transferase, family 2
IAG42_RS21430	COG1215	transferase activity, transferring glycosyl groups
IAG42_RS21435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAG42_RS21440	COG1134	teichoic acid transport
IAG42_RS21450	COG1309	transcriptional regulator
IAG42_RS21465	COG2197	response regulator
IAG42_RS21485	COG1846	Transcriptional regulator
IAG42_RS21490	COG1764	response to oxidative stress
IAG42_RS21500	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAG42_RS21505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAG42_RS21510	COG0395	ABC-type sugar transport system, permease component
IAG42_RS21515	COG1175	transmembrane transport
IAG42_RS21520	COG1653	transport
IAG42_RS21525	COG1674	ftsk spoiiie
IAG42_RS21530	COG0515	serine threonine protein kinase
IAG42_RS21535	COG0515	serine threonine protein kinase
IAG42_RS21540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IAG42_RS21555	COG2884	Cell division ATP-binding protein ftsE
IAG42_RS21565	COG0793	Belongs to the peptidase S41A family
IAG42_RS21570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IAG42_RS21590	COG0583	DNA-binding transcription factor activity
IAG42_RS21645	COG3973	AAA domain
IAG42_RS21655	COG0776	regulation of translation
IAG42_RS21660	COG0546	phosphoglycolate phosphatase activity
IAG42_RS21665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IAG42_RS21670	COG1678	Uncharacterized ACR, COG1678
IAG42_RS21730	COG1174	glycine betaine transport
IAG42_RS21735	COG1125	glycine betaine transport
IAG42_RS21735	COG0517	IMP dehydrogenase activity
IAG42_RS21740	COG1174	glycine betaine transport
IAG42_RS21750	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IAG42_RS21775	COG0277	FAD linked oxidase domain protein
IAG42_RS21810	COG1335	isochorismatase
IAG42_RS21820	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IAG42_RS21830	COG1113	amino acid transport
IAG42_RS21855	COG1234	tRNA 3'-trailer cleavage
IAG42_RS21860	COG1263	PTS System
IAG42_RS21865	COG1263	PTS System
IAG42_RS21870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAG42_RS21875	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IAG42_RS21885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IAG42_RS21915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAG42_RS21930	COG4555	ABC transporter
IAG42_RS21945	COG2733	membrane
IAG42_RS21975	COG2755	lipolytic protein G-D-S-L family
IAG42_RS21975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IAG42_RS21980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG42_RS22005	COG3708	Transcriptional regulator
IAG42_RS22005	COG2207	Transcriptional regulator
IAG42_RS22030	COG0270	DNA (cytosine-5-)-methyltransferase activity
IAG42_RS22125	COG3764	Sortase (surface protein transpeptidase)
IAG42_RS22135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG42_RS22155	COG4702	Belongs to the UPF0303 family
IAG42_RS22160	COG0673	inositol 2-dehydrogenase activity
IAG42_RS22175	COG2188	Transcriptional regulator
IAG42_RS22265	COG3397	chitin binding
IAG42_RS22280	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS22295	COG4585	Histidine kinase
IAG42_RS22300	COG2197	response regulator
IAG42_RS22315	COG1013	pyruvate-flavodoxin oxidoreductase activity
IAG42_RS22360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IAG42_RS22365	COG3321	synthase
IAG42_RS22365	COG0604	alcohol dehydrogenase
IAG42_RS22370	COG3320	Male sterility
IAG42_RS22370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG42_RS22385	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS22435	COG3903	Transcriptional regulator
IAG42_RS22435	COG3629	intracellular signal transduction
IAG42_RS22450	COG2409	Drug exporters of the RND superfamily
IAG42_RS22455	COG3629	intracellular signal transduction
IAG42_RS22455	COG3903	Transcriptional regulator
IAG42_RS22465	COG1126	abc transporter atp-binding protein
IAG42_RS22470	COG0765	amino acid transport
IAG42_RS22475	COG0765	amino acid transport
IAG42_RS22480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAG42_RS22490	COG0154	amidase activity
IAG42_RS22495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAG42_RS22510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS22595	COG3979	chitinase
IAG42_RS22605	COG0395	ABC-type sugar transport system, permease component
IAG42_RS22630	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IAG42_RS22635	COG4977	sequence-specific DNA binding
IAG42_RS22645	COG0589	response to stress
IAG42_RS22655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IAG42_RS22695	COG3486	L-lysine 6-monooxygenase (NADPH) activity
IAG42_RS22700	COG0076	glutamate decarboxylase activity
IAG42_RS22720	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS22725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IAG42_RS22735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG42_RS22740	COG1309	transcriptional regulator
IAG42_RS22750	COG1946	Acyl-CoA thioesterase
IAG42_RS22780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG42_RS22790	COG0028	Belongs to the TPP enzyme family
IAG42_RS22810	COG2356	endonuclease I
IAG42_RS22830	COG1472	Belongs to the glycosyl hydrolase 3 family
IAG42_RS22840	COG0456	acetyltransferase
IAG42_RS22840	COG1846	Transcriptional regulator
IAG42_RS22855	COG0596	Alpha beta hydrolase
IAG42_RS22875	COG0454	-acetyltransferase
IAG42_RS22880	COG1609	Transcriptional regulator
IAG42_RS22885	COG0673	inositol 2-dehydrogenase activity
IAG42_RS22905	COG0577	efflux transmembrane transporter activity
IAG42_RS22910	COG1136	(ABC) transporter
IAG42_RS22920	COG1869	D-ribose catabolic process
IAG42_RS22925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAG42_RS22930	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAG42_RS22935	COG1129	ABC transporter
IAG42_RS22955	COG1846	Transcriptional regulator
IAG42_RS22960	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS22980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IAG42_RS23030	COG3718	enzyme involved in inositol metabolism
IAG42_RS23035	COG3962	Belongs to the TPP enzyme family
IAG42_RS23080	COG2267	carboxylic ester hydrolase activity
IAG42_RS23090	COG0477	Major facilitator Superfamily
IAG42_RS23095	COG1063	alcohol dehydrogenase
IAG42_RS23105	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS23115	COG1309	transcriptional regulator
IAG42_RS23150	COG1595	DNA-templated transcription, initiation
IAG42_RS23195	COG0629	single-stranded DNA binding
IAG42_RS23245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IAG42_RS23275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAG42_RS23290	COG1486	melibiose metabolic process
IAG42_RS23295	COG0395	ABC-type sugar transport system, permease component
IAG42_RS23300	COG1175	transmembrane transport
IAG42_RS23305	COG1653	transport
IAG42_RS23310	COG1846	Transcriptional regulator
IAG42_RS23310	COG1940	carbohydrate kinase activity
IAG42_RS23325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IAG42_RS23335	COG0668	transmembrane transport
IAG42_RS23345	COG1136	(ABC) transporter
IAG42_RS23355	COG3291	Pkd domain containing protein
IAG42_RS23355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IAG42_RS23380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAG42_RS23390	COG2197	response regulator
IAG42_RS23415	COG4266	Belongs to the allantoicase family
IAG42_RS23430	COG0583	DNA-binding transcription factor activity
IAG42_RS23480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IAG42_RS23490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IAG42_RS23495	COG1113	amino acid transport
IAG42_RS23500	COG1113	amino acid transport
IAG42_RS23515	COG1113	amino acid transport
IAG42_RS23535	COG0475	glutathione-regulated potassium exporter activity
IAG42_RS23545	COG3594	Acyltransferase
IAG42_RS23565	COG0544	peptidyl-prolyl cis-trans isomerase activity
IAG42_RS23570	COG0740	serine-type endopeptidase activity
IAG42_RS23575	COG0740	serine-type endopeptidase activity
IAG42_RS23580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IAG42_RS23590	COG0525	valine-tRNA ligase activity
IAG42_RS23615	COG0285	dihydrofolate synthase activity
IAG42_RS23625	COG0105	UTP biosynthetic process
IAG42_RS23630	COG1077	Cell shape determining protein MreB Mrl
IAG42_RS23645	COG0768	penicillin binding
IAG42_RS23650	COG0772	Belongs to the SEDS family
IAG42_RS23685	COG1530	ribonuclease E activity
IAG42_RS23690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IAG42_RS23695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IAG42_RS23700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IAG42_RS23705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAG42_RS23710	COG1216	Glycosyl transferase, family 2
IAG42_RS23725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IAG42_RS23735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IAG42_RS23750	COG0501	Belongs to the peptidase M48B family
IAG42_RS23765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IAG42_RS23775	COG0799	negative regulation of ribosome biogenesis
IAG42_RS23780	COG0588	phosphoglycerate mutase activity
IAG42_RS23795	COG0477	Major facilitator Superfamily
IAG42_RS23815	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IAG42_RS23825	COG0495	leucyl-tRNA aminoacylation
IAG42_RS23835	COG1307	EDD domain protein, DegV family
IAG42_RS23840	COG1555	photosystem II stabilization
IAG42_RS23840	COG1596	polysaccharide export
IAG42_RS23855	COG2353	YceI-like domain
IAG42_RS23870	COG0268	Binds directly to 16S ribosomal RNA
IAG42_RS23875	COG0481	GTPase activity
IAG42_RS23905	COG1420	regulation of RNA biosynthetic process
IAG42_RS23910	COG0484	heat shock protein binding
IAG42_RS23930	COG0793	Belongs to the peptidase S41A family
IAG42_RS23930	COG4946	Tricorn protease homolog
IAG42_RS23935	COG0537	adenosine 5'-monophosphoramidase activity
IAG42_RS23940	COG1234	tRNA 3'-trailer cleavage
IAG42_RS23945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IAG42_RS23955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAG42_RS23965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IAG42_RS23975	COG2315	Protein conserved in bacteria
IAG42_RS24020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IAG42_RS24055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IAG42_RS24070	COG0412	Dienelactone hydrolase
IAG42_RS24095	COG0477	Major facilitator Superfamily
IAG42_RS24100	COG1959	2 iron, 2 sulfur cluster binding
IAG42_RS24110	COG1381	Involved in DNA repair and RecF pathway recombination
IAG42_RS24115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IAG42_RS24125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IAG42_RS24130	COG1121	(ABC) transporter
IAG42_RS24140	COG0423	glycine-tRNA ligase activity
IAG42_RS24150	COG0667	Aldo Keto reductase
IAG42_RS24155	COG0477	Major facilitator Superfamily
IAG42_RS24180	COG0574	Belongs to the PEP-utilizing enzyme family
IAG42_RS24180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IAG42_RS24205	COG2182	Extracellular solute-binding protein
IAG42_RS24215	COG0395	ABC-type sugar transport system, permease component
IAG42_RS24225	COG2146	nitrite reductase [NAD(P)H] activity
IAG42_RS24225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAG42_RS24230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAG42_RS24250	COG0243	molybdopterin cofactor binding
IAG42_RS24255	COG2949	membrane
IAG42_RS24265	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IAG42_RS24275	COG0730	response to heat
IAG42_RS24285	COG0358	DNA primase activity
IAG42_RS24290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IAG42_RS24305	COG1070	Carbohydrate kinase
IAG42_RS24335	COG0501	Belongs to the peptidase M48B family
IAG42_RS24350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IAG42_RS24355	COG0463	Glycosyl transferase, family 2
IAG42_RS24355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAG42_RS24365	COG1077	Cell shape determining protein MreB Mrl
IAG42_RS24390	COG1404	Belongs to the peptidase S8 family
IAG42_RS24395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS24400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAG42_RS24405	COG4521	taurine ABC transporter
IAG42_RS24410	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IAG42_RS24415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IAG42_RS24415	COG0825	malonyl-CoA metabolic process
IAG42_RS24435	COG2835	tetraacyldisaccharide 4'-kinase activity
IAG42_RS24455	COG4981	capsule polysaccharide biosynthetic process
IAG42_RS24485	COG1414	Transcriptional regulator
IAG42_RS24490	COG3386	PFAM SMP-30 Gluconolaconase
IAG42_RS24500	COG4214	carbohydrate transport
IAG42_RS24540	COG2130	NADP-dependent
IAG42_RS24545	COG1764	response to oxidative stress
IAG42_RS24575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAG42_RS24580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG42_RS24585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IAG42_RS24615	COG0789	Transcriptional regulator
IAG42_RS24630	COG1309	transcriptional regulator
IAG42_RS24635	COG0477	Major facilitator Superfamily
IAG42_RS24645	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IAG42_RS24690	COG1358	cellular component organization or biogenesis
IAG42_RS24745	COG2259	Doxx family
IAG42_RS24760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAG42_RS24775	COG0456	acetyltransferase
IAG42_RS24805	COG4122	O-methyltransferase activity
IAG42_RS24815	COG0477	Major facilitator Superfamily
IAG42_RS24855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IAG42_RS24920	COG2124	cytochrome p450
IAG42_RS24925	COG0183	Belongs to the thiolase family
IAG42_RS24945	COG3845	ABC transporter
IAG42_RS24965	COG2268	Band 7 protein
IAG42_RS24975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAG42_RS24990	COG1309	transcriptional regulator
IAG42_RS24995	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS25015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS25025	COG0860	N-Acetylmuramoyl-L-alanine amidase
IAG42_RS25040	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS25060	COG0583	DNA-binding transcription factor activity
IAG42_RS25065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG42_RS25070	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS25075	COG0183	Belongs to the thiolase family
IAG42_RS25080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAG42_RS25095	COG2197	response regulator
IAG42_RS25100	COG4585	Histidine kinase
IAG42_RS25110	COG1131	(ABC) transporter
IAG42_RS25115	COG2030	dehydratase
IAG42_RS25140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IAG42_RS25145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IAG42_RS25160	COG0800	Aldolase
IAG42_RS25165	COG3022	response to hydroperoxide
IAG42_RS25245	COG0384	phenazine biosynthesis protein PhzF
IAG42_RS25250	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS25255	COG3540	Alkaline phosphatase
IAG42_RS25265	COG2814	Major facilitator Superfamily
IAG42_RS25270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAG42_RS25300	COG0672	)-iron permease
IAG42_RS25305	COG2837	iron assimilation
IAG42_RS25320	COG5398	heme oxygenase
IAG42_RS25355	COG1994	Peptidase M50
IAG42_RS25375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IAG42_RS25380	COG0477	Major facilitator Superfamily
IAG42_RS25395	COG2814	Major facilitator Superfamily
IAG42_RS25400	COG2132	Multicopper oxidase
IAG42_RS25410	COG0531	amino acid
IAG42_RS25415	COG1609	Transcriptional regulator
IAG42_RS25420	COG1653	transport
IAG42_RS25425	COG0395	ABC-type sugar transport system, permease component
IAG42_RS25430	COG4209	transmembrane transport
IAG42_RS25435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAG42_RS25455	COG0174	glutamine synthetase
IAG42_RS25495	COG3511	phospholipase C
IAG42_RS25505	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IAG42_RS25515	COG1113	amino acid transport
IAG42_RS25520	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IAG42_RS25530	COG1609	Transcriptional regulator
IAG42_RS25575	COG2197	response regulator
IAG42_RS25585	COG0745	RESPONSE REGULATOR receiver
IAG42_RS25640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IAG42_RS25645	COG0321	lipoyl(octanoyl) transferase activity
IAG42_RS25670	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS25680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAG42_RS25705	COG1090	epimerase
IAG42_RS25725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IAG42_RS25735	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAG42_RS25740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAG42_RS25745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IAG42_RS25750	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IAG42_RS25765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IAG42_RS25765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IAG42_RS25770	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IAG42_RS25790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAG42_RS25815	COG4585	Histidine kinase
IAG42_RS25820	COG2197	response regulator
IAG42_RS25825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IAG42_RS25830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IAG42_RS25850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAG42_RS25860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IAG42_RS25865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IAG42_RS25875	COG1376	ErfK ybiS ycfS ynhG family protein
IAG42_RS25885	COG1845	cytochrome c oxidase, subunit III
IAG42_RS25890	COG2010	Cytochrome c
IAG42_RS25895	COG0723	plastoquinol--plastocyanin reductase activity
IAG42_RS25900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IAG42_RS25905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IAG42_RS25910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IAG42_RS25940	COG0791	NLP P60 protein
IAG42_RS25940	COG3883	PFAM NLP P60 protein
IAG42_RS25955	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS25975	COG0003	Pfam Anion-transporting ATPase
IAG42_RS25985	COG1940	carbohydrate kinase activity
IAG42_RS26015	COG4585	Histidine kinase
IAG42_RS26025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAG42_RS26035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IAG42_RS26040	COG0243	molybdopterin cofactor binding
IAG42_RS26045	COG2193	ferroxidase activity
IAG42_RS26050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IAG42_RS26060	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IAG42_RS26065	COG2815	serine threonine protein kinase
IAG42_RS26065	COG0515	serine threonine protein kinase
IAG42_RS26070	COG2022	thiamine diphosphate biosynthetic process
IAG42_RS26080	COG2022	thiamine diphosphate biosynthetic process
IAG42_RS26080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAG42_RS26090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAG42_RS26100	COG0352	thiamine-phosphate diphosphorylase activity
IAG42_RS26125	COG1309	transcriptional regulator
IAG42_RS26145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IAG42_RS26165	COG0714	Associated with various cellular activities
IAG42_RS26175	COG0275	rRNA processing
IAG42_RS26185	COG0768	penicillin binding
IAG42_RS26190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IAG42_RS26200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IAG42_RS26205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IAG42_RS26215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IAG42_RS26220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IAG42_RS26225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IAG42_RS26230	COG1496	oxidoreductase activity
IAG42_RS26240	COG1799	cell septum assembly
IAG42_RS26250	COG3599	regulation of cell shape
IAG42_RS26255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IAG42_RS26270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IAG42_RS26320	COG0587	DNA-directed DNA polymerase activity
IAG42_RS26350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IAG42_RS26370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IAG42_RS26375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAG42_RS26380	COG0131	Imidazoleglycerol-phosphate dehydratase
IAG42_RS26390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IAG42_RS26395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IAG42_RS26400	COG0251	oxidation-reduction process
IAG42_RS26405	COG0107	imidazoleglycerol-phosphate synthase activity
IAG42_RS26425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IAG42_RS26430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IAG42_RS26450	COG0134	indole-3-glycerol-phosphate synthase activity
IAG42_RS26455	COG0133	tryptophan synthase activity
IAG42_RS26460	COG0159	tryptophan synthase activity
IAG42_RS26470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IAG42_RS26475	COG2301	Belongs to the HpcH HpaI aldolase family
IAG42_RS26480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG42_RS26510	COG0067	glutamate synthase
IAG42_RS26510	COG0069	glutamate synthase activity
IAG42_RS26510	COG0070	glutamate synthase
IAG42_RS26545	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS26550	COG1024	Enoyl-CoA hydratase
IAG42_RS26555	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS26565	COG1309	transcriptional regulator
IAG42_RS26570	COG0183	Belongs to the thiolase family
IAG42_RS26580	COG1053	succinate dehydrogenase
IAG42_RS26590	COG0657	acetylesterase activity
IAG42_RS26595	COG2072	flavoprotein involved in K transport
IAG42_RS26600	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS26610	COG3971	2-oxopent-4-enoate hydratase activity
IAG42_RS26615	COG4569	acetaldehyde dehydrogenase (acetylating) activity
IAG42_RS26635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IAG42_RS26640	COG1414	Transcriptional regulator
IAG42_RS26645	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS26650	COG2267	carboxylic ester hydrolase activity
IAG42_RS26660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IAG42_RS26665	COG1309	transcriptional regulator
IAG42_RS26670	COG1278	Cold shock
IAG42_RS26675	COG0513	Belongs to the DEAD box helicase family
IAG42_RS26685	COG2365	Tyrosine phosphatase family
IAG42_RS26690	COG2070	2-Nitropropane dioxygenase
IAG42_RS26705	COG1024	Enoyl-CoA hydratase
IAG42_RS26725	COG0477	Major facilitator Superfamily
IAG42_RS26735	COG0366	Alpha amylase catalytic
IAG42_RS26735	COG1470	cell adhesion involved in biofilm formation
IAG42_RS26750	COG0287	Prephenate dehydrogenase
IAG42_RS26750	COG1605	Chorismate mutase
IAG42_RS26770	COG0737	Belongs to the 5'-nucleotidase family
IAG42_RS26780	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IAG42_RS26865	COG1643	Atp-dependent helicase
IAG42_RS26870	COG2226	methyltransferase
IAG42_RS26885	COG0237	dephospho-CoA kinase activity
IAG42_RS26905	COG2226	methyltransferase
IAG42_RS26940	COG1802	Transcriptional regulator
IAG42_RS26945	COG1953	Uracil, thiamine, allantoin
IAG42_RS27030	COG0598	Magnesium transport protein CorA
IAG42_RS27035	COG2226	methyltransferase
IAG42_RS27045	COG2313	pseudouridylate synthase activity
IAG42_RS27060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IAG42_RS27065	COG0584	glycerophosphoryl diester phosphodiesterase
IAG42_RS27075	COG0556	nucleotide-excision repair
IAG42_RS27100	COG0387	Pfam Sodium calcium exchanger
IAG42_RS27105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IAG42_RS27115	COG0765	amino acid transport
IAG42_RS27120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAG42_RS27125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAG42_RS27135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IAG42_RS27160	COG0395	ABC-type sugar transport system, permease component
IAG42_RS27165	COG1175	transmembrane transport
IAG42_RS27175	COG1621	beta-fructofuranosidase activity
IAG42_RS27180	COG1609	Transcriptional regulator
IAG42_RS27185	COG0322	excinuclease ABC activity
IAG42_RS27190	COG1660	Displays ATPase and GTPase activities
IAG42_RS27195	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IAG42_RS27200	COG1481	regulation of sporulation
IAG42_RS27205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IAG42_RS27210	COG0126	phosphoglycerate kinase activity
IAG42_RS27215	COG0149	triose-phosphate isomerase activity
IAG42_RS27220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IAG42_RS27230	COG0166	Belongs to the GPI family
IAG42_RS27240	COG0363	glucosamine-6-phosphate deaminase activity
IAG42_RS27255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IAG42_RS27265	COG0109	protoheme IX farnesyltransferase activity
IAG42_RS27285	COG0596	Alpha beta hydrolase
IAG42_RS27290	COG1612	heme a metabolic process
IAG42_RS27305	COG2746	aminoglycoside 3-N-acetyltransferase activity
IAG42_RS27320	COG0719	Fe-S assembly protein
IAG42_RS27330	COG0396	ATPase activity
IAG42_RS27335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IAG42_RS27340	COG0822	iron-sulfur transferase activity
IAG42_RS27345	COG2151	metal-sulfur cluster biosynthetic enzyme
IAG42_RS27350	COG2076	Multidrug Resistance protein
IAG42_RS27355	COG3226	Transcriptional regulator
IAG42_RS27360	COG2171	N-acyltransferase activity
IAG42_RS27365	COG1595	DNA-templated transcription, initiation
IAG42_RS27375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAG42_RS27410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAG42_RS27415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAG42_RS27445	COG0768	penicillin binding
IAG42_RS27450	COG2197	response regulator
IAG42_RS27455	COG4585	Histidine kinase
IAG42_RS27465	COG1414	Transcriptional regulator
IAG42_RS27480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IAG42_RS27485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IAG42_RS27490	COG5285	phytanoyl-CoA dioxygenase
IAG42_RS27495	COG1917	Cupin 2, conserved barrel domain protein
IAG42_RS27500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IAG42_RS27510	COG1104	cysteine desulfurase activity
IAG42_RS27540	COG1797	cobyrinic acid a,c-diamide synthase activity
IAG42_RS27555	COG1492	cobalamin metabolic process
IAG42_RS27560	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IAG42_RS27580	COG0235	Class ii aldolase
IAG42_RS27600	COG0488	(ABC) transporter
IAG42_RS27660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IAG42_RS27710	COG2372	response to copper ion
IAG42_RS27710	COG1276	copper resistance
IAG42_RS27725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAG42_RS27730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IAG42_RS27750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IAG42_RS27765	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS27770	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IAG42_RS27780	COG2186	Transcriptional regulator
IAG42_RS27800	COG0560	Phosphoserine phosphatase
IAG42_RS27800	COG3830	Belongs to the UPF0237 family
IAG42_RS27810	COG0842	Transport permease protein
IAG42_RS27810	COG1131	(ABC) transporter
IAG42_RS27810	COG1716	ATPase activity
IAG42_RS27820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IAG42_RS27835	COG2197	response regulator
IAG42_RS27855	COG1119	ATPase activity
IAG42_RS27875	COG1881	PFAM PEBP family protein
IAG42_RS27885	COG2094	Belongs to the DNA glycosylase MPG family
IAG42_RS27915	COG0647	UMP catabolic process
IAG42_RS27920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG42_RS27925	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAG42_RS27930	COG1120	ATPase activity
IAG42_RS27950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IAG42_RS27960	COG0497	DNA recombination
IAG42_RS27970	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS27985	COG3387	PFAM Glycoside hydrolase 15-related
IAG42_RS27990	COG0504	CTP synthase activity
IAG42_RS27995	COG0494	nUDIX hydrolase
IAG42_RS28005	COG0686	Belongs to the AlaDH PNT family
IAG42_RS28020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IAG42_RS28025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IAG42_RS28030	COG1187	pseudouridine synthase activity
IAG42_RS28035	COG1051	belongs to the nudix hydrolase family
IAG42_RS28035	COG1056	cytidyltransferase-related domain
IAG42_RS28045	COG3541	Predicted nucleotidyltransferase
IAG42_RS28070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IAG42_RS28080	COG1160	GTP binding
IAG42_RS28105	COG1129	ABC transporter
IAG42_RS28125	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS28140	COG0671	phosphoesterase, PA-phosphatase related
IAG42_RS28150	COG0477	Major facilitator Superfamily
IAG42_RS28155	COG1799	cell septum assembly
IAG42_RS28170	COG2018	Roadblock/LC7 domain
IAG42_RS28190	COG0765	amino acid transport
IAG42_RS28205	COG1126	abc transporter atp-binding protein
IAG42_RS28210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAG42_RS28245	COG0587	DNA-directed DNA polymerase activity
IAG42_RS28260	COG1846	Transcriptional regulator
IAG42_RS28295	COG1725	Transcriptional regulator
IAG42_RS28315	COG2755	lipolytic protein G-D-S-L family
IAG42_RS28320	COG0515	serine threonine protein kinase
IAG42_RS28350	COG2188	Transcriptional regulator
IAG42_RS28355	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IAG42_RS28375	COG1309	transcriptional regulator
IAG42_RS28380	COG2851	Citrate transporter
IAG42_RS28410	COG4412	M6 family metalloprotease domain protein
IAG42_RS28410	COG1404	Belongs to the peptidase S8 family
IAG42_RS28425	COG0477	Major facilitator Superfamily
IAG42_RS28440	COG0640	Transcriptional regulator
IAG42_RS28450	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS28460	COG1309	transcriptional regulator
IAG42_RS28500	COG0477	Major facilitator Superfamily
IAG42_RS28505	COG3876	Protein conserved in bacteria
IAG42_RS28510	COG0300	oxidoreductase activity
IAG42_RS28515	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS28540	COG2149	membrane
IAG42_RS28545	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IAG42_RS28570	COG3265	gluconokinase activity
IAG42_RS28575	COG2186	Transcriptional regulator
IAG42_RS28580	COG3012	SEC-C Motif Domain Protein
IAG42_RS28595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IAG42_RS28610	COG0166	Belongs to the GPI family
IAG42_RS28615	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IAG42_RS28630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAG42_RS28660	COG0667	Aldo Keto reductase
IAG42_RS28665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS28675	COG0598	Magnesium transport protein CorA
IAG42_RS28700	COG0215	cysteine-tRNA ligase activity
IAG42_RS28715	COG2186	Transcriptional regulator
IAG42_RS28745	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS28750	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS28760	COG0596	Alpha beta hydrolase
IAG42_RS28765	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IAG42_RS28780	COG2814	Major facilitator Superfamily
IAG42_RS28785	COG1846	Transcriptional regulator
IAG42_RS28790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS28795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IAG42_RS28800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IAG42_RS28805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IAG42_RS28810	COG1414	Transcriptional regulator
IAG42_RS28815	COG0646	methionine synthase
IAG42_RS28815	COG1410	methionine synthase
IAG42_RS28820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAG42_RS28835	COG2197	response regulator
IAG42_RS28845	COG0517	IMP dehydrogenase activity
IAG42_RS28845	COG1994	Peptidase M50
IAG42_RS28865	COG1222	aaa ATPase
IAG42_RS28870	COG4122	O-methyltransferase activity
IAG42_RS28885	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IAG42_RS28890	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IAG42_RS28905	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IAG42_RS28940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IAG42_RS28945	COG0805	protein transport
IAG42_RS28995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAG42_RS29000	COG0517	IMP dehydrogenase activity
IAG42_RS29000	COG4175	Glycine betaine
IAG42_RS29005	COG4176	ABC-type proline glycine betaine transport system permease component
IAG42_RS29035	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IAG42_RS29040	COG2186	Transcriptional regulator
IAG42_RS29045	COG0174	glutamine synthetase
IAG42_RS29100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IAG42_RS29105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IAG42_RS29110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IAG42_RS29115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IAG42_RS29120	COG5002	protein histidine kinase activity
IAG42_RS29125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IAG42_RS29130	COG0072	phenylalanine-tRNA ligase activity
IAG42_RS29130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAG42_RS29160	COG0697	spore germination
IAG42_RS29180	COG2815	serine threonine protein kinase
IAG42_RS29180	COG0515	serine threonine protein kinase
IAG42_RS29190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IAG42_RS29195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IAG42_RS29200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IAG42_RS29205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAG42_RS29210	COG1438	arginine binding
IAG42_RS29215	COG0385	Bile acid
IAG42_RS29230	COG0165	Argininosuccinate lyase
IAG42_RS29245	COG0714	Associated with various cellular activities
IAG42_RS29265	COG0477	Major facilitator Superfamily
IAG42_RS29270	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS29270	COG0204	Acyl-transferase
IAG42_RS29275	COG0584	glycerophosphoryl diester phosphodiesterase
IAG42_RS29300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IAG42_RS29305	COG2011	ABC-type metal ion transport system permease component
IAG42_RS29310	COG1464	Belongs to the NlpA lipoprotein family
IAG42_RS29325	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IAG42_RS29330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IAG42_RS29330	COG1648	precorrin-2 dehydrogenase activity
IAG42_RS29385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IAG42_RS29395	COG0454	-acetyltransferase
IAG42_RS29395	COG0456	acetyltransferase
IAG42_RS29455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IAG42_RS29475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IAG42_RS29480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IAG42_RS29500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IAG42_RS29505	COG1560	Kdo2-lipid A biosynthetic process
IAG42_RS29510	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS29520	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IAG42_RS29525	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IAG42_RS29530	COG0217	transcriptional regulatory protein
IAG42_RS29535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IAG42_RS29540	COG0632	four-way junction helicase activity
IAG42_RS29545	COG2255	four-way junction helicase activity
IAG42_RS29555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAG42_RS29560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAG42_RS29565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IAG42_RS29570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IAG42_RS29575	COG1196	nuclear chromosome segregation
IAG42_RS29590	COG0124	histidyl-tRNA synthetase
IAG42_RS29605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IAG42_RS29625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IAG42_RS29630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IAG42_RS29640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IAG42_RS29645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IAG42_RS29650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IAG42_RS29655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IAG42_RS29665	COG0006	proline dipeptidase activity
IAG42_RS29670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IAG42_RS29675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IAG42_RS29685	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IAG42_RS29690	COG0540	Belongs to the ATCase OTCase family
IAG42_RS29695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IAG42_RS29705	COG0505	Belongs to the CarA family
IAG42_RS29710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IAG42_RS29715	COG0167	dihydroorotate dehydrogenase activity
IAG42_RS29720	COG0284	orotidine-5'-phosphate decarboxylase activity
IAG42_RS29730	COG0194	GDP metabolic process
IAG42_RS29760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IAG42_RS29770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IAG42_RS29775	COG2390	Transcriptional regulator
IAG42_RS29795	COG0531	amino acid
IAG42_RS29830	COG2233	PERMEase
IAG42_RS29840	COG0738	Major facilitator superfamily
IAG42_RS29845	COG1940	carbohydrate kinase activity
IAG42_RS29845	COG1846	Transcriptional regulator
IAG42_RS29855	COG1595	DNA-templated transcription, initiation
IAG42_RS29870	COG3201	nicotinamide mononucleotide transporter
IAG42_RS29875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAG42_RS29875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAG42_RS29880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IAG42_RS29885	COG0140	phosphoribosyl-ATP diphosphatase activity
IAG42_RS29890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IAG42_RS29935	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS29970	COG0463	Glycosyl transferase, family 2
IAG42_RS29975	COG3030	protein affecting phage T7 exclusion by the F plasmid
IAG42_RS29985	COG2270	Major facilitator Superfamily
IAG42_RS30000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAG42_RS30025	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS30030	COG0438	transferase activity, transferring glycosyl groups
IAG42_RS30035	COG2755	lipolytic protein G-D-S-L family
IAG42_RS30095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IAG42_RS30100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IAG42_RS30120	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IAG42_RS30135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAG42_RS30145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IAG42_RS30175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IAG42_RS30195	COG1716	ATPase activity
IAG42_RS30215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IAG42_RS30225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IAG42_RS30225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IAG42_RS30255	COG0384	phenazine biosynthesis protein PhzF
IAG42_RS30290	COG0477	Major facilitator Superfamily
IAG42_RS30310	COG0697	spore germination
IAG42_RS30335	COG1309	transcriptional regulator
IAG42_RS30340	COG0300	oxidoreductase activity
IAG42_RS30350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IAG42_RS30360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IAG42_RS30365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IAG42_RS30390	COG0747	negative chemotaxis
IAG42_RS30395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IAG42_RS30425	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IAG42_RS30440	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS30455	COG1968	undecaprenyl-diphosphatase activity
IAG42_RS30480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IAG42_RS30530	COG0477	Major facilitator Superfamily
IAG42_RS30555	COG1832	CoA-binding protein
IAG42_RS30560	COG1739	Uncharacterized protein family UPF0029
IAG42_RS30565	COG0420	3'-5' exonuclease activity
IAG42_RS30570	COG0419	ATPase involved in DNA repair
IAG42_RS30575	COG1522	sequence-specific DNA binding
IAG42_RS30590	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS30605	COG0626	cystathionine gamma-synthase activity
IAG42_RS30635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAG42_RS30650	COG1595	DNA-templated transcription, initiation
IAG42_RS30655	COG2188	Transcriptional regulator
IAG42_RS30660	COG1940	carbohydrate kinase activity
IAG42_RS30665	COG2197	response regulator
IAG42_RS30670	COG4585	Histidine kinase
IAG42_RS30690	COG3663	DNA glycosylase
IAG42_RS30695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IAG42_RS30705	COG0500	methyltransferase
IAG42_RS30750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IAG42_RS30755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IAG42_RS30760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IAG42_RS30800	COG0740	serine-type endopeptidase activity
IAG42_RS30810	COG0831	urea catabolic process
IAG42_RS30815	COG0832	Belongs to the urease beta subunit family
IAG42_RS30820	COG0804	urea catabolic process
IAG42_RS30830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IAG42_RS30835	COG0829	nickel cation binding
IAG42_RS30850	COG0204	Acyl-transferase
IAG42_RS30870	COG0205	6-phosphofructokinase activity
IAG42_RS30885	COG0242	peptide deformylase activity
IAG42_RS30895	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS30900	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IAG42_RS30910	COG2124	cytochrome p450
IAG42_RS30915	COG3424	synthase
IAG42_RS30925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IAG42_RS30930	COG3239	Fatty acid desaturase
IAG42_RS31000	COG2018	Roadblock/LC7 domain
IAG42_RS31015	COG1946	Acyl-CoA thioesterase
IAG42_RS31030	COG1132	(ABC) transporter
IAG42_RS31035	COG1132	(ABC) transporter
IAG42_RS31060	COG1846	Transcriptional regulator
IAG42_RS31065	COG1132	(ABC) transporter
IAG42_RS31075	COG2072	flavoprotein involved in K transport
IAG42_RS31080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS31090	COG1116	anion transmembrane transporter activity
IAG42_RS31095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAG42_RS31100	COG0432	Pfam Uncharacterised protein family UPF0047
IAG42_RS31120	COG0386	Belongs to the glutathione peroxidase family
IAG42_RS31125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IAG42_RS31140	COG0604	alcohol dehydrogenase
IAG42_RS31150	COG2135	peptidase activity
IAG42_RS31185	COG4608	Belongs to the ABC transporter superfamily
IAG42_RS31190	COG4166	transmembrane transport
IAG42_RS31200	COG0477	Major facilitator Superfamily
IAG42_RS31245	COG0302	gtp cyclohydrolase
IAG42_RS31255	COG0488	(ABC) transporter
IAG42_RS31300	COG2080	2 iron, 2 sulfur cluster binding
IAG42_RS31305	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IAG42_RS31310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IAG42_RS31335	COG0542	response to heat
IAG42_RS31340	COG0248	Ppx GppA phosphatase
IAG42_RS31345	COG4770	biotin carboxylase activity
IAG42_RS31355	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS31360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAG42_RS31370	COG1609	Transcriptional regulator
IAG42_RS31380	COG1175	transmembrane transport
IAG42_RS31385	COG3833	ABC-type maltose transport systems, permease component
IAG42_RS31390	COG0366	Alpha amylase catalytic
IAG42_RS31410	COG1953	Uracil, thiamine, allantoin
IAG42_RS31455	COG1063	alcohol dehydrogenase
IAG42_RS31510	COG1309	transcriptional regulator
IAG42_RS31515	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAG42_RS31515	COG1902	pentaerythritol trinitrate reductase activity
IAG42_RS31520	COG2226	methyltransferase
IAG42_RS31525	COG3647	Membrane
IAG42_RS31540	COG2706	6-phosphogluconolactonase activity
IAG42_RS31555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IAG42_RS31570	COG1609	Transcriptional regulator
IAG42_RS31575	COG2252	PERMEase
IAG42_RS31580	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IAG42_RS31590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IAG42_RS31590	COG1017	nitric oxide dioxygenase activity
IAG42_RS31595	COG1959	2 iron, 2 sulfur cluster binding
IAG42_RS31600	COG1902	pentaerythritol trinitrate reductase activity
IAG42_RS31605	COG0640	Transcriptional regulator
IAG42_RS31610	COG0493	'glutamate synthase
IAG42_RS31625	COG1309	transcriptional regulator
IAG42_RS31645	COG0671	phosphoesterase, PA-phosphatase related
IAG42_RS31665	COG1846	Transcriptional regulator
IAG42_RS31670	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAG42_RS31685	COG0584	glycerophosphoryl diester phosphodiesterase
IAG42_RS31695	COG4044	May play a role in the intracellular transport of hydrophobic ligands
IAG42_RS31700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS31705	COG0657	acetylesterase activity
IAG42_RS31730	COG0204	Acyl-transferase
IAG42_RS31750	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IAG42_RS31775	COG1280	lysine exporter protein (LysE YggA)
IAG42_RS31780	COG1522	sequence-specific DNA binding
IAG42_RS31810	COG0445	tRNA wobble uridine modification
IAG42_RS31815	COG4585	Histidine kinase
IAG42_RS31820	COG2197	response regulator
IAG42_RS31845	COG2223	nitrite transmembrane transporter activity
IAG42_RS31850	COG1349	DNA-binding transcription factor activity
IAG42_RS31870	COG1940	carbohydrate kinase activity
IAG42_RS31905	COG0577	efflux transmembrane transporter activity
IAG42_RS31905	COG1136	(ABC) transporter
IAG42_RS31930	COG1349	DNA-binding transcription factor activity
IAG42_RS31940	COG0464	growth
IAG42_RS31965	COG1215	transferase activity, transferring glycosyl groups
IAG42_RS31990	COG1051	belongs to the nudix hydrolase family
IAG42_RS31995	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS32010	COG2838	Isocitrate dehydrogenase
IAG42_RS32015	COG3590	peptidase
IAG42_RS32020	COG0412	Dienelactone hydrolase
IAG42_RS32030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAG42_RS32035	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IAG42_RS32040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IAG42_RS32050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IAG42_RS32055	COG2226	methyltransferase
IAG42_RS32065	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS32070	COG1309	transcriptional regulator
IAG42_RS32080	COG0242	peptide deformylase activity
IAG42_RS32100	COG1902	pentaerythritol trinitrate reductase activity
IAG42_RS32100	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAG42_RS32130	COG1461	Dihydroxyacetone kinase
IAG42_RS32135	COG2376	Dihydroxyacetone kinase
IAG42_RS32165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IAG42_RS32190	COG4948	Mandelate Racemase Muconate Lactonizing
IAG42_RS32205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAG42_RS32210	COG0531	amino acid
IAG42_RS32225	COG0402	S-adenosylhomocysteine deaminase activity
IAG42_RS32230	COG2233	PERMEase
IAG42_RS32235	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IAG42_RS32245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAG42_RS32250	COG0179	Fumarylacetoacetate (FAA) hydrolase
IAG42_RS32255	COG2271	Major facilitator Superfamily
IAG42_RS32280	COG1686	Belongs to the peptidase S11 family
IAG42_RS32295	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IAG42_RS32320	COG1695	Transcriptional regulator
IAG42_RS32330	COG2267	carboxylic ester hydrolase activity
IAG42_RS32335	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS32345	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS32365	COG1396	sequence-specific DNA binding
IAG42_RS32370	COG3189	MarR family transcriptional regulator
IAG42_RS32375	COG0542	response to heat
IAG42_RS32405	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS32430	COG3458	cephalosporin-C deacetylase activity
IAG42_RS32460	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS32465	COG0395	ABC-type sugar transport system, permease component
IAG42_RS32470	COG1175	transmembrane transport
IAG42_RS32480	COG1609	Transcriptional regulator
IAG42_RS32495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAG42_RS32500	COG2070	2-Nitropropane dioxygenase
IAG42_RS32510	COG2366	antibiotic biosynthetic process
IAG42_RS32515	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS32535	COG1024	Enoyl-CoA hydratase
IAG42_RS32560	COG0589	response to stress
IAG42_RS32605	COG0477	Major facilitator Superfamily
IAG42_RS32620	COG2814	Major facilitator Superfamily
IAG42_RS32630	COG3387	PFAM Glycoside hydrolase 15-related
IAG42_RS32645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAG42_RS32650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IAG42_RS32655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IAG42_RS32695	COG1937	Protein conserved in bacteria
IAG42_RS32700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IAG42_RS32725	COG0328	RNA-DNA hybrid ribonuclease activity
IAG42_RS32755	COG3001	Fructosamine kinase
IAG42_RS32760	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IAG42_RS32765	COG3135	benzoate transporter
IAG42_RS32780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IAG42_RS32810	COG2318	DinB family
IAG42_RS32815	COG2066	Belongs to the glutaminase family
IAG42_RS32815	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IAG42_RS32835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG42_RS32840	COG0444	Belongs to the ABC transporter superfamily
IAG42_RS32865	COG0549	Belongs to the carbamate kinase family
IAG42_RS32875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IAG42_RS32880	COG1304	FMN binding
IAG42_RS32885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IAG42_RS32930	COG4977	sequence-specific DNA binding
IAG42_RS32955	COG2226	methyltransferase
IAG42_RS32975	COG1228	amidohydrolase
IAG42_RS33000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IAG42_RS33035	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG42_RS33060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAG42_RS33090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAG42_RS33095	COG2945	thiolester hydrolase activity
IAG42_RS33095	COG0596	Alpha beta hydrolase
IAG42_RS33100	COG2824	Alkylphosphonate utilization operon protein PhnA
IAG42_RS33110	COG0659	secondary active sulfate transmembrane transporter activity
IAG42_RS33155	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS33170	COG1309	transcriptional regulator
IAG42_RS33185	COG2186	Transcriptional regulator
IAG42_RS33190	COG0402	S-adenosylhomocysteine deaminase activity
IAG42_RS33195	COG4166	transmembrane transport
IAG42_RS33205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG42_RS33215	COG4608	Belongs to the ABC transporter superfamily
IAG42_RS33240	COG1309	transcriptional regulator
IAG42_RS33245	COG0702	epimerase
IAG42_RS33315	COG4941	Belongs to the sigma-70 factor family
IAG42_RS33320	COG3795	YCII-related domain
IAG42_RS33325	COG0346	lactoylglutathione lyase activity
IAG42_RS33330	COG0640	Transcriptional regulator
IAG42_RS33340	COG1404	Belongs to the peptidase S8 family
IAG42_RS33355	COG1846	Transcriptional regulator
IAG42_RS33370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IAG42_RS33390	COG0601	transmembrane transport
IAG42_RS33395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG42_RS33400	COG0747	negative chemotaxis
IAG42_RS33405	COG2318	DinB family
IAG42_RS33420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAG42_RS33425	COG0789	Transcriptional regulator
IAG42_RS33430	COG0659	secondary active sulfate transmembrane transporter activity
IAG42_RS33435	COG2814	Major facilitator Superfamily
IAG42_RS33440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAG42_RS33455	COG0488	(ABC) transporter
IAG42_RS33460	COG0488	(ABC) transporter
IAG42_RS33475	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IAG42_RS33480	COG0395	ABC-type sugar transport system, permease component
IAG42_RS33485	COG1175	transmembrane transport
IAG42_RS33490	COG2182	Extracellular solute-binding protein
IAG42_RS33520	COG0656	L-ascorbic acid biosynthetic process
IAG42_RS33535	COG2814	Major facilitator Superfamily
IAG42_RS33550	COG0492	ferredoxin-NADP+ reductase activity
IAG42_RS33565	COG2340	Cysteine-rich secretory protein family
IAG42_RS33595	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IAG42_RS33610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG42_RS33620	COG0601	transmembrane transport
IAG42_RS33625	COG0444	Belongs to the ABC transporter superfamily
IAG42_RS33630	COG4608	Belongs to the ABC transporter superfamily
IAG42_RS33635	COG0402	S-adenosylhomocysteine deaminase activity
IAG42_RS33655	COG2188	Transcriptional regulator
IAG42_RS33675	COG1131	(ABC) transporter
IAG42_RS33690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAG42_RS33735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IAG42_RS33740	COG2188	Transcriptional regulator
IAG42_RS33760	COG2223	nitrite transmembrane transporter activity
IAG42_RS33765	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS33785	COG4977	sequence-specific DNA binding
IAG42_RS33830	COG2124	cytochrome p450
IAG42_RS33865	COG2226	methyltransferase
IAG42_RS33905	COG0739	heme binding
IAG42_RS33910	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IAG42_RS33915	COG2186	Transcriptional regulator
IAG42_RS33920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAG42_RS33925	COG3622	Belongs to the hyi family
IAG42_RS33930	COG2271	Major facilitator Superfamily
IAG42_RS33935	COG0235	Class ii aldolase
IAG42_RS33940	COG3395	kinase activity
IAG42_RS33945	COG2084	Dehydrogenase
IAG42_RS33960	COG2814	Major facilitator Superfamily
IAG42_RS33965	COG1902	pentaerythritol trinitrate reductase activity
IAG42_RS34005	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS34095	COG0657	acetylesterase activity
IAG42_RS34125	COG0454	-acetyltransferase
IAG42_RS34145	COG2197	response regulator
IAG42_RS34150	COG4585	Histidine kinase
IAG42_RS34170	COG0477	Major facilitator Superfamily
IAG42_RS34185	COG1215	transferase activity, transferring glycosyl groups
IAG42_RS34205	COG2409	Drug exporters of the RND superfamily
IAG42_RS34215	COG4585	Histidine kinase
IAG42_RS34220	COG2197	response regulator
IAG42_RS34235	COG0515	serine threonine protein kinase
IAG42_RS34240	COG2084	Dehydrogenase
IAG42_RS34245	COG0583	DNA-binding transcription factor activity
IAG42_RS34270	COG1309	transcriptional regulator
IAG42_RS34280	COG0154	amidase activity
IAG42_RS34285	COG4166	transmembrane transport
IAG42_RS34295	COG0444	Belongs to the ABC transporter superfamily
IAG42_RS34315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IAG42_RS34340	COG0832	Belongs to the urease beta subunit family
IAG42_RS34340	COG0831	urea catabolic process
IAG42_RS34360	COG1846	Transcriptional regulator
IAG42_RS34365	COG2409	Drug exporters of the RND superfamily
IAG42_RS34370	COG0702	epimerase
IAG42_RS34395	COG1959	2 iron, 2 sulfur cluster binding
IAG42_RS34435	COG2311	Membrane
IAG42_RS34450	COG1335	isochorismatase
IAG42_RS34470	COG0187	DNA topoisomerase II activity
IAG42_RS34520	COG1309	transcriptional regulator
IAG42_RS34560	COG0657	acetylesterase activity
IAG42_RS34575	COG1295	ribonuclease BN
IAG42_RS34600	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IAG42_RS34615	COG2378	regulation of single-species biofilm formation
IAG42_RS34620	COG0596	Alpha beta hydrolase
IAG42_RS34630	COG3395	kinase activity
IAG42_RS34635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IAG42_RS34680	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS34700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IAG42_RS34705	COG4948	Mandelate Racemase Muconate Lactonizing
IAG42_RS34715	COG2226	methyltransferase
IAG42_RS34720	COG4166	transmembrane transport
IAG42_RS34725	COG0601	transmembrane transport
IAG42_RS34730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAG42_RS34760	COG1335	isochorismatase
IAG42_RS34780	COG0640	Transcriptional regulator
IAG42_RS34795	COG0604	alcohol dehydrogenase
IAG42_RS34800	COG1940	carbohydrate kinase activity
IAG42_RS34820	COG0395	ABC-type sugar transport system, permease component
IAG42_RS34865	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS34900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAG42_RS34940	COG1136	(ABC) transporter
IAG42_RS34975	COG2233	PERMEase
IAG42_RS34985	COG2233	PERMEase
IAG42_RS35000	COG0604	alcohol dehydrogenase
IAG42_RS35000	COG3321	synthase
IAG42_RS35015	COG0009	L-threonylcarbamoyladenylate synthase
IAG42_RS35025	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IAG42_RS35025	COG1082	Xylose isomerase domain protein TIM barrel
IAG42_RS35030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IAG42_RS35035	COG0477	Major facilitator Superfamily
IAG42_RS35055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IAG42_RS35060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IAG42_RS35080	COG1595	DNA-templated transcription, initiation
IAG42_RS35100	COG1595	DNA-templated transcription, initiation
IAG42_RS35125	COG0668	transmembrane transport
IAG42_RS35135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IAG42_RS35220	COG0488	(ABC) transporter
IAG42_RS35230	COG1595	DNA-templated transcription, initiation
IAG42_RS35245	COG0596	Alpha beta hydrolase
IAG42_RS35250	COG1414	Transcriptional regulator
IAG42_RS35255	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS35270	COG1278	Cold shock
IAG42_RS35275	COG0513	Belongs to the DEAD box helicase family
IAG42_RS35335	COG0583	DNA-binding transcription factor activity
IAG42_RS35360	COG0604	alcohol dehydrogenase
IAG42_RS35360	COG3321	synthase
IAG42_RS35370	COG0483	inositol monophosphate 1-phosphatase activity
IAG42_RS35375	COG0583	DNA-binding transcription factor activity
IAG42_RS35385	COG1733	regulation of RNA biosynthetic process
IAG42_RS35400	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IAG42_RS35410	COG0583	DNA-binding transcription factor activity
IAG42_RS35435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IAG42_RS35465	COG1090	epimerase
IAG42_RS35480	COG2072	flavoprotein involved in K transport
IAG42_RS35485	COG0798	PFAM Bile acid sodium symporter
IAG42_RS35495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAG42_RS35500	COG0492	ferredoxin-NADP+ reductase activity
IAG42_RS35525	COG2815	serine threonine protein kinase
IAG42_RS35525	COG0515	serine threonine protein kinase
IAG42_RS35545	COG1595	DNA-templated transcription, initiation
IAG42_RS35555	COG1073	alpha beta
IAG42_RS35625	COG2208	phosphoserine phosphatase activity
IAG42_RS35625	COG2172	sigma factor antagonist activity
IAG42_RS35625	COG1366	Belongs to the anti-sigma-factor antagonist family
IAG42_RS35650	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS35655	COG1309	transcriptional regulator
IAG42_RS35680	COG2957	Belongs to the agmatine deiminase family
IAG42_RS35685	COG0747	negative chemotaxis
IAG42_RS35700	COG0444	Belongs to the ABC transporter superfamily
IAG42_RS35705	COG4608	Belongs to the ABC transporter superfamily
IAG42_RS35720	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IAG42_RS35735	COG2957	Belongs to the agmatine deiminase family
IAG42_RS35845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IAG42_RS35895	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IAG42_RS35920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAG42_RS35925	COG0604	alcohol dehydrogenase
IAG42_RS35925	COG3321	synthase
IAG42_RS35930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IAG42_RS35945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAG42_RS35965	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS35990	COG1819	glycosyl
IAG42_RS36025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG42_RS36030	COG3425	synthase
IAG42_RS36040	COG1024	Enoyl-CoA hydratase
IAG42_RS36050	COG2867	negative regulation of translational initiation
IAG42_RS36070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IAG42_RS36090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IAG42_RS36115	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IAG42_RS36120	COG2272	Belongs to the type-B carboxylesterase lipase family
IAG42_RS36165	COG1192	Involved in chromosome partitioning
IAG42_RS36180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IAG42_RS36185	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IAG42_RS36220	COG0702	epimerase
IAG42_RS36235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAG42_RS36245	COG0477	Major facilitator Superfamily
IAG42_RS36255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IAG42_RS36260	COG1021	2,3-dihydroxybenzoate-AMP ligase
IAG42_RS36265	COG2423	ornithine cyclodeaminase activity
IAG42_RS36270	COG2124	cytochrome p450
IAG42_RS36275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IAG42_RS36275	COG0512	Glutamine amidotransferase of anthranilate synthase
IAG42_RS36280	COG0287	Prephenate dehydrogenase
IAG42_RS36285	COG1605	Chorismate mutase
IAG42_RS36290	COG2890	protein-(glutamine-N5) methyltransferase activity
IAG42_RS36300	COG0022	dehydrogenase e1 component
IAG42_RS36305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAG42_RS36305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG42_RS36305	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS36305	COG3321	synthase
IAG42_RS36305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG42_RS36305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAG42_RS36305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG42_RS36305	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS36305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG42_RS36305	COG3321	synthase
IAG42_RS36315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG42_RS36320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAG42_RS36325	COG3425	synthase
IAG42_RS36335	COG1024	Enoyl-CoA hydratase
IAG42_RS36340	COG0300	oxidoreductase activity
IAG42_RS36340	COG3321	synthase
IAG42_RS36340	COG4221	oxidoreductase activity
IAG42_RS36340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG42_RS36370	COG3629	intracellular signal transduction
IAG42_RS36450	COG2197	response regulator
IAG42_RS36455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG42_RS36465	COG1024	Enoyl-CoA hydratase
IAG42_RS36480	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IAG42_RS36485	COG3251	PFAM MbtH domain protein
IAG42_RS36510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IAG42_RS36515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAG42_RS36520	COG1410	methionine synthase
IAG42_RS36520	COG0646	methionine synthase
IAG42_RS36540	COG0488	(ABC) transporter
IAG42_RS36550	COG0488	(ABC) transporter
IAG42_RS36555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IAG42_RS36585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IAG42_RS36605	COG0601	transmembrane transport
IAG42_RS36620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG42_RS36630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IAG42_RS36640	COG3425	synthase
IAG42_RS36655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG42_RS36655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG42_RS36655	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS36655	COG3321	synthase
IAG42_RS36655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG42_RS36655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAG42_RS36655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG42_RS36655	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS36655	COG3321	synthase
IAG42_RS36655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAG42_RS36675	COG2070	2-Nitropropane dioxygenase
IAG42_RS36675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IAG42_RS36680	COG1024	Enoyl-CoA hydratase
IAG42_RS36720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAG42_RS36750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IAG42_RS36760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG42_RS36775	COG0159	tryptophan synthase activity
IAG42_RS36780	COG0662	Cupin 2, conserved barrel domain protein
IAG42_RS36785	COG1960	acyl-CoA dehydrogenase activity
IAG42_RS36800	COG0134	indole-3-glycerol-phosphate synthase activity
IAG42_RS36815	COG0702	epimerase
IAG42_RS36820	COG3321	synthase
IAG42_RS36820	COG0604	alcohol dehydrogenase
IAG42_RS36865	COG0702	epimerase
IAG42_RS36875	COG0215	cysteine-tRNA ligase activity
IAG42_RS36970	COG2076	Multidrug Resistance protein
IAG42_RS36985	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS37000	COG2197	response regulator
IAG42_RS37005	COG4585	Histidine kinase
IAG42_RS37010	COG0586	Pfam SNARE associated Golgi protein
IAG42_RS37015	COG0604	alcohol dehydrogenase
IAG42_RS37015	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS37015	COG3321	synthase
IAG42_RS37020	COG2207	Transcriptional regulator
IAG42_RS37025	COG0667	Aldo Keto reductase
IAG42_RS37060	COG2175	clavaminate synthase activity
IAG42_RS37075	COG2175	clavaminate synthase activity
IAG42_RS37085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IAG42_RS37100	COG2223	nitrite transmembrane transporter activity
IAG42_RS37120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IAG42_RS37140	COG4865	methylaspartate mutase activity
IAG42_RS37150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAG42_RS37245	COG1660	Displays ATPase and GTPase activities
IAG42_RS37335	COG0860	N-Acetylmuramoyl-L-alanine amidase
IAG42_RS37335	COG3103	Sh3 type 3 domain protein
IAG42_RS37335	COG4991	sh3 domain protein
IAG42_RS37440	COG1660	Displays ATPase and GTPase activities
IAG42_RS37470	COG2124	cytochrome p450
IAG42_RS37660	COG0739	heme binding
IAG42_RS37980	COG1079	Belongs to the binding-protein-dependent transport system permease family
IAG42_RS38145	COG0577	efflux transmembrane transporter activity
IAG42_RS38195	COG2318	DinB family
IAG42_RS38215	COG3227	Zinc metalloprotease (Elastase)
IAG42_RS38220	COG3227	Zinc metalloprotease (Elastase)
IAG42_RS38260	COG3321	synthase
IAG42_RS38260	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS38260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG42_RS38260	COG0300	oxidoreductase activity
IAG42_RS38260	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS38260	COG1028	Short-chain dehydrogenase reductase Sdr
IAG42_RS38260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAG42_RS38260	COG0318	PFAM AMP-dependent synthetase and ligase
IAG42_RS38260	COG0300	oxidoreductase activity
IAG42_RS38260	COG3321	synthase
IAG42_RS38295	COG1404	Belongs to the peptidase S8 family
IAG42_RS38380	COG1404	Belongs to the peptidase S8 family
IAG42_RS38420	COG4221	oxidoreductase activity
IAG42_RS38420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAG42_RS38420	COG0300	oxidoreductase activity
IAG42_RS38420	COG3321	synthase