locus-tag	class	description
SXIM_RS00010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SXIM_RS00215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SXIM_RS00225	COG0300	oxidoreductase activity
SXIM_RS00275	COG0431	NADPH-dependent FMN reductase
SXIM_RS00295	COG0789	Transcriptional regulator
SXIM_RS00320	COG1175	transmembrane transport
SXIM_RS00325	COG0395	ABC-type sugar transport system, permease component
SXIM_RS00370	COG0717	Belongs to the dCTP deaminase family
SXIM_RS00375	COG0717	Belongs to the dCTP deaminase family
SXIM_RS00385	COG0494	nUDIX hydrolase
SXIM_RS00390	COG2226	methyltransferase
SXIM_RS00415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SXIM_RS00425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SXIM_RS00430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SXIM_RS00445	COG0666	response to abiotic stimulus
SXIM_RS00460	COG2197	response regulator
SXIM_RS00485	COG0432	Pfam Uncharacterised protein family UPF0047
SXIM_RS00490	COG1609	Transcriptional regulator
SXIM_RS00495	COG3254	rhamnose metabolic process
SXIM_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS00505	COG3347	Dehydrogenase
SXIM_RS00510	COG1070	Carbohydrate kinase
SXIM_RS00515	COG0247	lactate metabolic process
SXIM_RS00520	COG1139	Iron-sulfur cluster binding protein
SXIM_RS00525	COG1556	Lactate utilization protein
SXIM_RS00535	COG0667	Aldo Keto reductase
SXIM_RS00575	COG1132	(ABC) transporter
SXIM_RS00600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SXIM_RS00610	COG3397	chitin binding
SXIM_RS00625	COG0640	Transcriptional regulator
SXIM_RS00630	COG1132	(ABC) transporter
SXIM_RS00635	COG1132	(ABC) transporter
SXIM_RS00655	COG2018	Roadblock/LC7 domain
SXIM_RS00670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SXIM_RS00725	COG1940	carbohydrate kinase activity
SXIM_RS00735	COG0697	spore germination
SXIM_RS00745	COG3940	Belongs to the glycosyl hydrolase 43 family
SXIM_RS00770	COG1940	carbohydrate kinase activity
SXIM_RS00790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SXIM_RS00795	COG2197	response regulator
SXIM_RS00800	COG4585	Histidine kinase
SXIM_RS00810	COG4608	Belongs to the ABC transporter superfamily
SXIM_RS00815	COG0444	Belongs to the ABC transporter superfamily
SXIM_RS00820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SXIM_RS00825	COG0601	transmembrane transport
SXIM_RS00835	COG3458	cephalosporin-C deacetylase activity
SXIM_RS00870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SXIM_RS00900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SXIM_RS00910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SXIM_RS00950	COG3321	synthase
SXIM_RS00950	COG0604	alcohol dehydrogenase
SXIM_RS00960	COG0318	PFAM AMP-dependent synthetase and ligase
SXIM_RS00965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SXIM_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS01010	COG0625	glutathione transferase activity
SXIM_RS01015	COG0189	ligase activity
SXIM_RS01020	COG0189	ligase activity
SXIM_RS01050	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SXIM_RS01055	COG2080	2 iron, 2 sulfur cluster binding
SXIM_RS01065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SXIM_RS01120	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SXIM_RS01130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SXIM_RS01140	COG1621	beta-fructofuranosidase activity
SXIM_RS01150	COG1175	transmembrane transport
SXIM_RS01160	COG1609	Transcriptional regulator
SXIM_RS01170	COG0346	lactoylglutathione lyase activity
SXIM_RS01185	COG1733	regulation of RNA biosynthetic process
SXIM_RS01205	COG0640	Transcriptional regulator
SXIM_RS01220	COG1116	anion transmembrane transporter activity
SXIM_RS01230	COG0247	lactate metabolic process
SXIM_RS01230	COG0277	FAD linked oxidase domain protein
SXIM_RS01245	COG0523	cobalamin synthesis protein
SXIM_RS01275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SXIM_RS01280	COG3842	ATPase activity
SXIM_RS01320	COG1609	Transcriptional regulator
SXIM_RS01325	COG0673	inositol 2-dehydrogenase activity
SXIM_RS01330	COG2807	transmembrane transport
SXIM_RS01335	COG2186	Transcriptional regulator
SXIM_RS01355	COG2197	response regulator
SXIM_RS01370	COG1131	(ABC) transporter
SXIM_RS01430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SXIM_RS01430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SXIM_RS01440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SXIM_RS01480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SXIM_RS01495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SXIM_RS01505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SXIM_RS01515	COG1960	acyl-CoA dehydrogenase activity
SXIM_RS01545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SXIM_RS01550	COG0140	phosphoribosyl-ATP diphosphatase activity
SXIM_RS01555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SXIM_RS01560	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SXIM_RS01560	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SXIM_RS01565	COG3201	nicotinamide mononucleotide transporter
SXIM_RS01595	COG2390	Transcriptional regulator
SXIM_RS01600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SXIM_RS01610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SXIM_RS01630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SXIM_RS01640	COG1758	RNA polymerase activity
SXIM_RS01645	COG0194	GDP metabolic process
SXIM_RS01655	COG0284	orotidine-5'-phosphate decarboxylase activity
SXIM_RS01660	COG0167	dihydroorotate dehydrogenase activity
SXIM_RS01665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SXIM_RS01670	COG0505	Belongs to the CarA family
SXIM_RS01680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SXIM_RS01685	COG0540	Belongs to the ATCase OTCase family
SXIM_RS01690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SXIM_RS01700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SXIM_RS01705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SXIM_RS01710	COG0006	proline dipeptidase activity
SXIM_RS01720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SXIM_RS01725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SXIM_RS01730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SXIM_RS01735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SXIM_RS01750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SXIM_RS01770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SXIM_RS01790	COG0124	histidyl-tRNA synthetase
SXIM_RS01800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SXIM_RS01805	COG1196	nuclear chromosome segregation
SXIM_RS01810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SXIM_RS01815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SXIM_RS01820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SXIM_RS01825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SXIM_RS01835	COG2255	four-way junction helicase activity
SXIM_RS01840	COG0632	four-way junction helicase activity
SXIM_RS01845	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SXIM_RS01850	COG0217	transcriptional regulatory protein
SXIM_RS01855	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SXIM_RS01860	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SXIM_RS01870	COG0438	transferase activity, transferring glycosyl groups
SXIM_RS01875	COG1560	Kdo2-lipid A biosynthetic process
SXIM_RS01880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SXIM_RS01895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SXIM_RS01940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SXIM_RS01940	COG0512	Glutamine amidotransferase of anthranilate synthase
SXIM_RS01980	COG1648	precorrin-2 dehydrogenase activity
SXIM_RS01980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SXIM_RS01985	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SXIM_RS02000	COG1464	Belongs to the NlpA lipoprotein family
SXIM_RS02010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SXIM_RS02030	COG0584	glycerophosphoryl diester phosphodiesterase
SXIM_RS02035	COG0204	Acyl-transferase
SXIM_RS02035	COG0318	PFAM AMP-dependent synthetase and ligase
SXIM_RS02055	COG0714	Associated with various cellular activities
SXIM_RS02075	COG0165	Argininosuccinate lyase
SXIM_RS02095	COG1438	arginine binding
SXIM_RS02100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SXIM_RS02105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SXIM_RS02110	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SXIM_RS02115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SXIM_RS02120	COG4221	oxidoreductase activity
SXIM_RS02140	COG0697	spore germination
SXIM_RS02150	COG1649	PFAM Uncharacterised BCR, COG1649
SXIM_RS02165	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SXIM_RS02175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SXIM_RS02185	COG0072	phenylalanine-tRNA ligase activity
SXIM_RS02185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SXIM_RS02190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SXIM_RS02195	COG5002	protein histidine kinase activity
SXIM_RS02200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SXIM_RS02205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SXIM_RS02210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SXIM_RS02215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SXIM_RS02260	COG1012	belongs to the aldehyde dehydrogenase family
SXIM_RS02270	COG2186	Transcriptional regulator
SXIM_RS02275	COG0531	amino acid
SXIM_RS02280	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SXIM_RS02285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SXIM_RS02295	COG0805	protein transport
SXIM_RS02300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SXIM_RS02330	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SXIM_RS02345	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SXIM_RS02350	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SXIM_RS02360	COG4122	O-methyltransferase activity
SXIM_RS02365	COG1222	aaa ATPase
SXIM_RS02390	COG1994	Peptidase M50
SXIM_RS02390	COG0517	IMP dehydrogenase activity
SXIM_RS02400	COG2197	response regulator
SXIM_RS02405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SXIM_RS02410	COG0646	methionine synthase
SXIM_RS02410	COG1410	methionine synthase
SXIM_RS02415	COG1414	Transcriptional regulator
SXIM_RS02420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SXIM_RS02425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SXIM_RS02430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SXIM_RS02440	COG0215	cysteine-tRNA ligase activity
SXIM_RS02460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SXIM_RS02465	COG0667	Aldo Keto reductase
SXIM_RS02540	COG5520	Belongs to the glycosyl hydrolase 30 family
SXIM_RS02545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SXIM_RS02555	COG1012	belongs to the aldehyde dehydrogenase family
SXIM_RS02560	COG0596	Alpha beta hydrolase
SXIM_RS02575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SXIM_RS02590	COG1802	Transcriptional regulator
SXIM_RS02600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SXIM_RS02635	COG4948	Mandelate Racemase Muconate Lactonizing
SXIM_RS02650	COG1309	transcriptional regulator
SXIM_RS02655	COG0110	maltose O-acetyltransferase activity
SXIM_RS02660	COG3226	Transcriptional regulator
SXIM_RS02670	COG1309	transcriptional regulator
SXIM_RS02705	COG1113	amino acid transport
SXIM_RS02725	COG0477	Major facilitator Superfamily
SXIM_RS02730	COG2197	response regulator
SXIM_RS02775	COG1595	DNA-templated transcription, initiation
SXIM_RS02790	COG0438	transferase activity, transferring glycosyl groups
SXIM_RS02810	COG3842	ATPase activity
SXIM_RS02815	COG2828	Protein conserved in bacteria
SXIM_RS02820	COG0583	DNA-binding transcription factor activity
SXIM_RS02825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SXIM_RS02835	COG0586	Pfam SNARE associated Golgi protein
SXIM_RS02840	COG0475	glutathione-regulated potassium exporter activity
SXIM_RS02895	COG1131	(ABC) transporter
SXIM_RS02905	COG0475	glutathione-regulated potassium exporter activity
SXIM_RS02920	COG1757	Na H antiporter
SXIM_RS02925	COG0583	DNA-binding transcription factor activity
SXIM_RS02930	COG2072	flavoprotein involved in K transport
SXIM_RS03020	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SXIM_RS03025	COG2188	Transcriptional regulator
SXIM_RS03045	COG0738	Major facilitator superfamily
SXIM_RS03075	COG1414	Transcriptional regulator
SXIM_RS03085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SXIM_RS03090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SXIM_RS03115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SXIM_RS03160	COG2226	methyltransferase
SXIM_RS03165	COG0596	Alpha beta hydrolase
SXIM_RS03170	COG4941	Belongs to the sigma-70 factor family
SXIM_RS03175	COG3795	YCII-related domain
SXIM_RS03205	COG2890	protein-(glutamine-N5) methyltransferase activity
SXIM_RS03210	COG0028	Belongs to the TPP enzyme family
SXIM_RS03215	COG3959	Transketolase, thiamine diphosphate binding domain
SXIM_RS03220	COG3958	Transketolase
SXIM_RS03260	COG0366	Alpha amylase catalytic
SXIM_RS03270	COG1126	abc transporter atp-binding protein
SXIM_RS03275	COG1725	Transcriptional regulator
SXIM_RS03285	COG2259	Doxx family
SXIM_RS03290	COG3384	dioxygenase
SXIM_RS03340	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SXIM_RS03355	COG2018	Roadblock/LC7 domain
SXIM_RS03440	COG0515	serine threonine protein kinase
SXIM_RS03440	COG2815	serine threonine protein kinase
SXIM_RS03445	COG0800	Aldolase
SXIM_RS03455	COG3619	membrane
SXIM_RS03460	COG2376	Dihydroxyacetone kinase
SXIM_RS03465	COG1461	Dihydroxyacetone kinase
SXIM_RS03485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SXIM_RS03500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SXIM_RS03505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SXIM_RS03520	COG1349	DNA-binding transcription factor activity
SXIM_RS03530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SXIM_RS03530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SXIM_RS03545	COG2364	Membrane
SXIM_RS03555	COG3030	protein affecting phage T7 exclusion by the F plasmid
SXIM_RS03560	COG1216	Glycosyl transferase, family 2
SXIM_RS03570	COG1228	amidohydrolase
SXIM_RS03575	COG1522	sequence-specific DNA binding
SXIM_RS03580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SXIM_RS03585	COG1131	(ABC) transporter
SXIM_RS03595	COG4585	Histidine kinase
SXIM_RS03600	COG2197	response regulator
SXIM_RS03610	COG0300	oxidoreductase activity
SXIM_RS03615	COG0300	oxidoreductase activity
SXIM_RS03625	COG0829	nickel cation binding
SXIM_RS03630	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SXIM_RS03640	COG0804	urea catabolic process
SXIM_RS03645	COG0832	Belongs to the urease beta subunit family
SXIM_RS03650	COG0831	urea catabolic process
SXIM_RS03675	COG1799	cell septum assembly
SXIM_RS03680	COG1960	acyl-CoA dehydrogenase activity
SXIM_RS03685	COG0477	Major facilitator Superfamily
SXIM_RS03690	COG0671	phosphoesterase, PA-phosphatase related
SXIM_RS03710	COG1160	GTP binding
SXIM_RS03720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SXIM_RS03730	COG1187	pseudouridine synthase activity
SXIM_RS03735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SXIM_RS03755	COG0686	Belongs to the AlaDH PNT family
SXIM_RS03765	COG0494	nUDIX hydrolase
SXIM_RS03770	COG0504	CTP synthase activity
SXIM_RS03775	COG3387	PFAM Glycoside hydrolase 15-related
SXIM_RS03805	COG0497	DNA recombination
SXIM_RS03810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SXIM_RS03835	COG0647	UMP catabolic process
SXIM_RS03880	COG2094	Belongs to the DNA glycosylase MPG family
SXIM_RS03890	COG1881	PFAM PEBP family protein
SXIM_RS03910	COG1119	ATPase activity
SXIM_RS03930	COG2197	response regulator
SXIM_RS03940	COG0842	Transport permease protein
SXIM_RS03940	COG1131	(ABC) transporter
SXIM_RS03940	COG1716	ATPase activity
SXIM_RS03945	COG3830	Belongs to the UPF0237 family
SXIM_RS03945	COG0560	Phosphoserine phosphatase
SXIM_RS03960	COG2807	transmembrane transport
SXIM_RS03965	COG2186	Transcriptional regulator
SXIM_RS03970	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SXIM_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS04000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SXIM_RS04015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SXIM_RS04060	COG1024	Enoyl-CoA hydratase
SXIM_RS04070	COG0488	(ABC) transporter
SXIM_RS04115	COG0456	acetyltransferase
SXIM_RS04120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SXIM_RS04125	COG1917	Cupin 2, conserved barrel domain protein
SXIM_RS04130	COG5285	phytanoyl-CoA dioxygenase
SXIM_RS04150	COG1175	transmembrane transport
SXIM_RS04155	COG0395	ABC-type sugar transport system, permease component
SXIM_RS04180	COG1414	Transcriptional regulator
SXIM_RS04185	COG2252	PERMEase
SXIM_RS04195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SXIM_RS04200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SXIM_RS04210	COG3866	Pectate lyase
SXIM_RS04230	COG1802	Transcriptional regulator
SXIM_RS04260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SXIM_RS04270	COG2171	N-acyltransferase activity
SXIM_RS04275	COG2076	Multidrug Resistance protein
SXIM_RS04285	COG2151	metal-sulfur cluster biosynthetic enzyme
SXIM_RS04290	COG0822	iron-sulfur transferase activity
SXIM_RS04295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SXIM_RS04300	COG0396	ATPase activity
SXIM_RS04310	COG0719	Fe-S assembly protein
SXIM_RS04325	COG1609	Transcriptional regulator
SXIM_RS04330	COG1175	transmembrane transport
SXIM_RS04335	COG0395	ABC-type sugar transport system, permease component
SXIM_RS04345	COG0673	inositol 2-dehydrogenase activity
SXIM_RS04350	COG1131	(ABC) transporter
SXIM_RS04360	COG1612	heme a metabolic process
SXIM_RS04375	COG0109	protoheme IX farnesyltransferase activity
SXIM_RS04380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SXIM_RS04385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SXIM_RS04400	COG0363	glucosamine-6-phosphate deaminase activity
SXIM_RS04405	COG0166	Belongs to the GPI family
SXIM_RS04420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SXIM_RS04425	COG0149	triose-phosphate isomerase activity
SXIM_RS04430	COG0126	phosphoglycerate kinase activity
SXIM_RS04435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SXIM_RS04440	COG1481	regulation of sporulation
SXIM_RS04445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SXIM_RS04450	COG1660	Displays ATPase and GTPase activities
SXIM_RS04455	COG0322	excinuclease ABC activity
SXIM_RS04460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SXIM_RS04470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SXIM_RS04485	COG0556	nucleotide-excision repair
SXIM_RS04490	COG0584	glycerophosphoryl diester phosphodiesterase
SXIM_RS04495	COG0739	heme binding
SXIM_RS04500	COG5001	Diguanylate cyclase
SXIM_RS04500	COG3300	MHYT domain
SXIM_RS04550	COG0237	dephospho-CoA kinase activity
SXIM_RS04560	COG0539	negative regulation of cytoplasmic translation
SXIM_RS04635	COG0673	inositol 2-dehydrogenase activity
SXIM_RS04670	COG0287	Prephenate dehydrogenase
SXIM_RS04670	COG1605	Chorismate mutase
SXIM_RS04685	COG0395	ABC-type sugar transport system, permease component
SXIM_RS04690	COG1175	transmembrane transport
SXIM_RS04710	COG0067	glutamate synthase
SXIM_RS04710	COG0069	glutamate synthase activity
SXIM_RS04710	COG0070	glutamate synthase
SXIM_RS04720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SXIM_RS04740	COG0159	tryptophan synthase activity
SXIM_RS04745	COG0133	tryptophan synthase activity
SXIM_RS04755	COG0134	indole-3-glycerol-phosphate synthase activity
SXIM_RS04775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SXIM_RS04780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SXIM_RS04800	COG3401	FG-GAP repeat protein
SXIM_RS04810	COG1175	transmembrane transport
SXIM_RS04815	COG0395	ABC-type sugar transport system, permease component
SXIM_RS04830	COG0577	efflux transmembrane transporter activity
SXIM_RS04830	COG1136	(ABC) transporter
SXIM_RS04840	COG0583	DNA-binding transcription factor activity
SXIM_RS04850	COG1053	succinate dehydrogenase
SXIM_RS04855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SXIM_RS04865	COG0107	imidazoleglycerol-phosphate synthase activity
SXIM_RS04870	COG0251	oxidation-reduction process
SXIM_RS04875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SXIM_RS04880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SXIM_RS04885	COG0131	Imidazoleglycerol-phosphate dehydratase
SXIM_RS04890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SXIM_RS04895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SXIM_RS04915	COG0346	lactoylglutathione lyase activity
SXIM_RS04940	COG0587	DNA-directed DNA polymerase activity
SXIM_RS04975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SXIM_RS04985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SXIM_RS04990	COG3599	regulation of cell shape
SXIM_RS05000	COG1799	cell septum assembly
SXIM_RS05005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SXIM_RS05025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SXIM_RS05035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SXIM_RS05040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SXIM_RS05045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SXIM_RS05050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SXIM_RS05055	COG0768	penicillin binding
SXIM_RS05065	COG0275	rRNA processing
SXIM_RS05075	COG0714	Associated with various cellular activities
SXIM_RS05125	COG0352	thiamine-phosphate diphosphorylase activity
SXIM_RS05140	COG2022	thiamine diphosphate biosynthetic process
SXIM_RS05140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SXIM_RS05150	COG2022	thiamine diphosphate biosynthetic process
SXIM_RS05160	COG0515	serine threonine protein kinase
SXIM_RS05160	COG2815	serine threonine protein kinase
SXIM_RS05170	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SXIM_RS05175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SXIM_RS05180	COG2193	ferroxidase activity
SXIM_RS05190	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SXIM_RS05230	COG3467	pyridoxamine 5'-phosphate
SXIM_RS05235	COG1940	carbohydrate kinase activity
SXIM_RS05245	COG0003	Pfam Anion-transporting ATPase
SXIM_RS05255	COG0438	transferase activity, transferring glycosyl groups
SXIM_RS05290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SXIM_RS05295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SXIM_RS05300	COG0723	plastoquinol--plastocyanin reductase activity
SXIM_RS05305	COG2010	Cytochrome c
SXIM_RS05310	COG1845	cytochrome c oxidase, subunit III
SXIM_RS05320	COG1376	ErfK ybiS ycfS ynhG family protein
SXIM_RS05330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SXIM_RS05335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SXIM_RS05345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SXIM_RS05360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SXIM_RS05365	COG2197	response regulator
SXIM_RS05370	COG4585	Histidine kinase
SXIM_RS05390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SXIM_RS05410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SXIM_RS05420	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SXIM_RS05425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SXIM_RS05430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SXIM_RS05435	COG0508	dehydrogenase complex catalyzes the overall conversion of
SXIM_RS05445	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SXIM_RS05495	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS05525	COG0321	lipoyl(octanoyl) transferase activity
SXIM_RS05530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SXIM_RS05565	COG0673	inositol 2-dehydrogenase activity
SXIM_RS05585	COG2197	response regulator
SXIM_RS05605	COG0366	Alpha amylase catalytic
SXIM_RS05610	COG3833	ABC-type maltose transport systems, permease component
SXIM_RS05635	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SXIM_RS05640	COG0174	glutamine synthetase
SXIM_RS05670	COG2124	cytochrome p450
SXIM_RS05680	COG0501	Belongs to the peptidase M48B family
SXIM_RS05690	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SXIM_RS05730	COG0366	Alpha amylase catalytic
SXIM_RS05735	COG0667	Aldo Keto reductase
SXIM_RS05750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SXIM_RS05755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SXIM_RS05760	COG1120	ATPase activity
SXIM_RS05765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SXIM_RS05770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SXIM_RS05775	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SXIM_RS05805	COG4122	O-methyltransferase activity
SXIM_RS05830	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS05840	COG0745	RESPONSE REGULATOR receiver
SXIM_RS05860	COG2072	flavoprotein involved in K transport
SXIM_RS05895	COG0702	epimerase
SXIM_RS05915	COG0489	protein tyrosine kinase activity
SXIM_RS05920	COG0297	glycogen (starch) synthase activity
SXIM_RS05935	COG0583	DNA-binding transcription factor activity
SXIM_RS05950	COG0702	epimerase
SXIM_RS06010	COG0346	lactoylglutathione lyase activity
SXIM_RS06015	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SXIM_RS06020	COG2814	Major facilitator Superfamily
SXIM_RS06025	COG3540	Alkaline phosphatase
SXIM_RS06035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SXIM_RS06050	COG3903	Transcriptional regulator
SXIM_RS06050	COG3629	intracellular signal transduction
SXIM_RS06090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SXIM_RS06115	COG2066	Belongs to the glutaminase family
SXIM_RS06120	COG2267	carboxylic ester hydrolase activity
SXIM_RS06125	COG2197	response regulator
SXIM_RS06130	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS06150	COG3022	response to hydroperoxide
SXIM_RS06165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SXIM_RS06190	COG2226	methyltransferase
SXIM_RS06195	COG0438	transferase activity, transferring glycosyl groups
SXIM_RS06300	COG1358	cellular component organization or biogenesis
SXIM_RS06355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SXIM_RS06370	COG4585	Histidine kinase
SXIM_RS06375	COG2197	response regulator
SXIM_RS06405	COG0667	Aldo Keto reductase
SXIM_RS06420	COG2233	PERMEase
SXIM_RS06440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SXIM_RS06445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SXIM_RS06450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SXIM_RS06460	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SXIM_RS06490	COG1846	Transcriptional regulator
SXIM_RS06490	COG0456	acetyltransferase
SXIM_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS06515	COG1309	transcriptional regulator
SXIM_RS06580	COG0406	alpha-ribazole phosphatase activity
SXIM_RS06610	COG4948	Mandelate Racemase Muconate Lactonizing
SXIM_RS06635	COG4214	carbohydrate transport
SXIM_RS06645	COG0542	response to heat
SXIM_RS06655	COG2764	glyoxalase bleomycin resistance protein dioxygenase
SXIM_RS06690	COG2130	NADP-dependent
SXIM_RS06695	COG3386	PFAM SMP-30 Gluconolaconase
SXIM_RS06725	COG0745	RESPONSE REGULATOR receiver
SXIM_RS06730	COG2205	protein histidine kinase activity
SXIM_RS06740	COG2072	flavoprotein involved in K transport
SXIM_RS06765	COG0318	PFAM AMP-dependent synthetase and ligase
SXIM_RS06775	COG3629	intracellular signal transduction
SXIM_RS06775	COG3903	Transcriptional regulator
SXIM_RS06790	COG1695	Transcriptional regulator
SXIM_RS06815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SXIM_RS06820	COG0142	geranyltranstransferase activity
SXIM_RS06845	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SXIM_RS06855	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SXIM_RS06895	COG0235	Class ii aldolase
SXIM_RS06900	COG3395	kinase activity
SXIM_RS06915	COG1349	DNA-binding transcription factor activity
SXIM_RS06920	COG1070	Carbohydrate kinase
SXIM_RS06925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SXIM_RS06930	COG0358	DNA primase activity
SXIM_RS06940	COG0028	Belongs to the TPP enzyme family
SXIM_RS06960	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SXIM_RS06975	COG0243	molybdopterin cofactor binding
SXIM_RS06990	COG0702	epimerase
SXIM_RS06995	COG1324	tolerance protein
SXIM_RS07030	COG2146	nitrite reductase [NAD(P)H] activity
SXIM_RS07030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SXIM_RS07035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SXIM_RS07035	COG2146	nitrite reductase [NAD(P)H] activity
SXIM_RS07045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SXIM_RS07075	COG1609	Transcriptional regulator
SXIM_RS07085	COG1175	transmembrane transport
SXIM_RS07095	COG1472	Belongs to the glycosyl hydrolase 3 family
SXIM_RS07110	COG3290	protein histidine kinase activity
SXIM_RS07115	COG4565	transcriptional regulatory protein
SXIM_RS07130	COG0574	Belongs to the PEP-utilizing enzyme family
SXIM_RS07130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SXIM_RS07140	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SXIM_RS07165	COG0667	Aldo Keto reductase
SXIM_RS07180	COG0423	glycine-tRNA ligase activity
SXIM_RS07190	COG1121	(ABC) transporter
SXIM_RS07195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SXIM_RS07230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SXIM_RS07235	COG1381	Involved in DNA repair and RecF pathway recombination
SXIM_RS07250	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS07255	COG1733	regulation of RNA biosynthetic process
SXIM_RS07260	COG2318	DinB family
SXIM_RS07280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SXIM_RS07290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SXIM_RS07310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SXIM_RS07325	COG1486	melibiose metabolic process
SXIM_RS07330	COG3507	Belongs to the glycosyl hydrolase 43 family
SXIM_RS07335	COG1234	tRNA 3'-trailer cleavage
SXIM_RS07340	COG0537	adenosine 5'-monophosphoramidase activity
SXIM_RS07345	COG4946	Tricorn protease homolog
SXIM_RS07345	COG0793	Belongs to the peptidase S41A family
SXIM_RS07350	COG0733	neurotransmitter:sodium symporter activity
SXIM_RS07365	COG0484	heat shock protein binding
SXIM_RS07370	COG1420	regulation of RNA biosynthetic process
SXIM_RS07395	COG0481	GTPase activity
SXIM_RS07400	COG0268	Binds directly to 16S ribosomal RNA
SXIM_RS07420	COG1063	alcohol dehydrogenase
SXIM_RS07435	COG1307	EDD domain protein, DegV family
SXIM_RS07445	COG0495	leucyl-tRNA aminoacylation
SXIM_RS07460	COG0588	phosphoglycerate mutase activity
SXIM_RS07475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SXIM_RS07480	COG0501	Belongs to the peptidase M48B family
SXIM_RS07495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SXIM_RS07505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SXIM_RS07515	COG1215	transferase activity, transferring glycosyl groups
SXIM_RS07530	COG3046	protein related to deoxyribodipyrimidine photolyase
SXIM_RS07550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SXIM_RS07555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SXIM_RS07560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SXIM_RS07565	COG1530	ribonuclease E activity
SXIM_RS07590	COG0772	Belongs to the SEDS family
SXIM_RS07595	COG0768	penicillin binding
SXIM_RS07610	COG1077	Cell shape determining protein MreB Mrl
SXIM_RS07615	COG0105	UTP biosynthetic process
SXIM_RS07625	COG0285	dihydrofolate synthase activity
SXIM_RS07630	COG1136	(ABC) transporter
SXIM_RS07665	COG0525	valine-tRNA ligase activity
SXIM_RS07680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SXIM_RS07685	COG0740	serine-type endopeptidase activity
SXIM_RS07690	COG0740	serine-type endopeptidase activity
SXIM_RS07695	COG0544	peptidyl-prolyl cis-trans isomerase activity
SXIM_RS07715	COG3594	Acyltransferase
SXIM_RS07725	COG1674	ftsk spoiiie
SXIM_RS07765	COG0739	heme binding
SXIM_RS07775	COG4552	Acetyltransferase involved in intracellular survival and related
SXIM_RS07790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SXIM_RS07795	COG0601	transmembrane transport
SXIM_RS07800	COG0747	negative chemotaxis
SXIM_RS07815	COG0698	ribose 5-phosphate isomerase
SXIM_RS07850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SXIM_RS07855	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SXIM_RS07890	COG0668	transmembrane transport
SXIM_RS07895	COG0604	alcohol dehydrogenase
SXIM_RS07900	COG3311	Transcriptional regulator
SXIM_RS07905	COG1569	PIN domain
SXIM_RS07910	COG0456	acetyltransferase
SXIM_RS07930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SXIM_RS08005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SXIM_RS08085	COG1960	acyl-CoA dehydrogenase activity
SXIM_RS08090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SXIM_RS08115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SXIM_RS08120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SXIM_RS08125	COG0028	Belongs to the TPP enzyme family
SXIM_RS08135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SXIM_RS08155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SXIM_RS08160	COG4948	Mandelate Racemase Muconate Lactonizing
SXIM_RS08165	COG1301	dicarboxylic acid transport
SXIM_RS08175	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SXIM_RS08180	COG2409	Drug exporters of the RND superfamily
SXIM_RS08190	COG1132	(ABC) transporter
SXIM_RS08195	COG0789	Transcriptional regulator
SXIM_RS08200	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS08205	COG1309	transcriptional regulator
SXIM_RS08210	COG0596	Alpha beta hydrolase
SXIM_RS08355	COG2255	four-way junction helicase activity
SXIM_RS08370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SXIM_RS08375	COG0569	domain protein
SXIM_RS08380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SXIM_RS08480	COG1175	transmembrane transport
SXIM_RS08490	COG2188	Transcriptional regulator
SXIM_RS08495	COG0673	inositol 2-dehydrogenase activity
SXIM_RS08505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SXIM_RS08515	COG3718	enzyme involved in inositol metabolism
SXIM_RS08520	COG3962	Belongs to the TPP enzyme family
SXIM_RS08545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SXIM_RS08580	COG2249	NAD(P)H dehydrogenase (quinone) activity
SXIM_RS08585	COG0583	DNA-binding transcription factor activity
SXIM_RS08595	COG0768	penicillin binding
SXIM_RS08605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SXIM_RS08610	COG0793	Belongs to the peptidase S41A family
SXIM_RS08610	COG3409	Peptidoglycan-binding domain 1 protein
SXIM_RS08615	COG2177	Part of the ABC transporter FtsEX involved in
SXIM_RS08620	COG2884	Cell division ATP-binding protein ftsE
SXIM_RS08640	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SXIM_RS08645	COG0515	serine threonine protein kinase
SXIM_RS08650	COG0515	serine threonine protein kinase
SXIM_RS08665	COG1653	transport
SXIM_RS08670	COG1175	transmembrane transport
SXIM_RS08675	COG0395	ABC-type sugar transport system, permease component
SXIM_RS08680	COG2226	methyltransferase
SXIM_RS08685	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SXIM_RS08690	COG1215	transferase activity, transferring glycosyl groups
SXIM_RS08710	COG1396	sequence-specific DNA binding
SXIM_RS08710	COG3800	Transcriptional regulator
SXIM_RS08735	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SXIM_RS08740	COG0438	transferase activity, transferring glycosyl groups
SXIM_RS08750	COG3629	intracellular signal transduction
SXIM_RS08750	COG3903	Transcriptional regulator
SXIM_RS08770	COG2409	Drug exporters of the RND superfamily
SXIM_RS08775	COG0702	epimerase
SXIM_RS08785	COG2409	Drug exporters of the RND superfamily
SXIM_RS08790	COG1408	metallophosphoesterase
SXIM_RS08795	COG2902	Dehydrogenase
SXIM_RS08815	COG0653	protein targeting
SXIM_RS08820	COG3214	Protein conserved in bacteria
SXIM_RS08825	COG2197	response regulator
SXIM_RS08830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SXIM_RS08840	COG0823	Involved in the tonB-independent uptake of proteins
SXIM_RS08850	COG0745	RESPONSE REGULATOR receiver
SXIM_RS08870	COG0714	Associated with various cellular activities
SXIM_RS08880	COG0583	DNA-binding transcription factor activity
SXIM_RS08885	COG0667	Aldo Keto reductase
SXIM_RS08920	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SXIM_RS08925	COG1482	cell wall glycoprotein biosynthetic process
SXIM_RS08935	COG2835	tetraacyldisaccharide 4'-kinase activity
SXIM_RS08980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SXIM_RS08985	COG0778	Nitroreductase
SXIM_RS08985	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SXIM_RS09005	COG1316	TRANSCRIPTIONal
SXIM_RS09045	COG1607	acyl-coa hydrolase
SXIM_RS09050	COG1316	TRANSCRIPTIONal
SXIM_RS09055	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SXIM_RS09075	COG1309	transcriptional regulator
SXIM_RS09095	COG0739	heme binding
SXIM_RS09120	COG5002	protein histidine kinase activity
SXIM_RS09125	COG0745	RESPONSE REGULATOR receiver
SXIM_RS09140	COG1191	sigma factor activity
SXIM_RS09155	COG1228	amidohydrolase
SXIM_RS09165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SXIM_RS09170	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SXIM_RS09175	COG0019	diaminopimelate decarboxylase activity
SXIM_RS09195	COG2755	lipolytic protein G-D-S-L family
SXIM_RS09200	COG0183	Belongs to the thiolase family
SXIM_RS09240	COG1136	(ABC) transporter
SXIM_RS09240	COG0577	efflux transmembrane transporter activity
SXIM_RS09245	COG0577	efflux transmembrane transporter activity
SXIM_RS09250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SXIM_RS09265	COG4104	PAAR repeat-containing protein
SXIM_RS09265	COG3209	COG3209 Rhs family protein
SXIM_RS09280	COG2146	nitrite reductase [NAD(P)H] activity
SXIM_RS09280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SXIM_RS09300	COG0148	phosphopyruvate hydratase activity
SXIM_RS09305	COG1652	LysM domain
SXIM_RS09315	COG2124	cytochrome p450
SXIM_RS09320	COG4585	Histidine kinase
SXIM_RS09330	COG0515	serine threonine protein kinase
SXIM_RS09370	COG0577	efflux transmembrane transporter activity
SXIM_RS09375	COG3594	Acyltransferase
SXIM_RS09410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SXIM_RS09415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SXIM_RS09420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SXIM_RS09425	COG0193	aminoacyl-tRNA hydrolase activity
SXIM_RS09455	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SXIM_RS09465	COG1309	transcriptional regulator
SXIM_RS09475	COG3401	FG-GAP repeat protein
SXIM_RS09480	COG4106	trans-aconitate 2-methyltransferase activity
SXIM_RS09505	COG0464	growth
SXIM_RS09520	COG2197	response regulator
SXIM_RS09535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SXIM_RS09560	COG0488	(ABC) transporter
SXIM_RS09565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SXIM_RS09570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SXIM_RS09575	COG0084	hydrolase, TatD family'
SXIM_RS09605	COG2409	Drug exporters of the RND superfamily
SXIM_RS09610	COG4946	Tricorn protease homolog
SXIM_RS09610	COG0793	Belongs to the peptidase S41A family
SXIM_RS09625	COG1316	TRANSCRIPTIONal
SXIM_RS09635	COG0640	Transcriptional regulator
SXIM_RS09640	COG1309	transcriptional regulator
SXIM_RS09655	COG0708	Exodeoxyribonuclease III
SXIM_RS09660	COG4209	transmembrane transport
SXIM_RS09665	COG0395	ABC-type sugar transport system, permease component
SXIM_RS09670	COG1653	transport
SXIM_RS09680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SXIM_RS09685	COG0535	radical SAM domain protein
SXIM_RS09705	COG0254	rRNA binding
SXIM_RS09715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SXIM_RS09720	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SXIM_RS09725	COG1120	ATPase activity
SXIM_RS09730	COG4607	ABC-type enterochelin transport system periplasmic component
SXIM_RS09750	COG2188	Transcriptional regulator
SXIM_RS09755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SXIM_RS09760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SXIM_RS09775	COG0825	malonyl-CoA metabolic process
SXIM_RS09775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SXIM_RS09790	COG0596	Alpha beta hydrolase
SXIM_RS09795	COG1216	Glycosyl transferase, family 2
SXIM_RS09820	COG2188	Transcriptional regulator
SXIM_RS09835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SXIM_RS09840	COG0521	Mo-molybdopterin cofactor biosynthetic process
SXIM_RS09840	COG0315	cyclic pyranopterin monophosphate synthase activity
SXIM_RS09845	COG0315	cyclic pyranopterin monophosphate synthase activity
SXIM_RS09855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SXIM_RS09860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SXIM_RS09880	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SXIM_RS09895	COG1764	response to oxidative stress
SXIM_RS09900	COG1846	Transcriptional regulator
SXIM_RS09905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SXIM_RS09915	COG3404	Formiminotransferase-cyclodeaminase
SXIM_RS09920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SXIM_RS09925	COG1733	regulation of RNA biosynthetic process
SXIM_RS09935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SXIM_RS09935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SXIM_RS09935	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SXIM_RS09945	COG1349	DNA-binding transcription factor activity
SXIM_RS09955	COG1309	transcriptional regulator
SXIM_RS09965	COG1473	amidohydrolase
SXIM_RS09990	COG4948	Mandelate Racemase Muconate Lactonizing
SXIM_RS10020	COG4948	Mandelate Racemase Muconate Lactonizing
SXIM_RS10025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SXIM_RS10030	COG0456	acetyltransferase
SXIM_RS10045	COG0802	atpase or kinase
SXIM_RS10050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SXIM_RS10060	COG0736	holo-[acyl-carrier-protein] synthase activity
SXIM_RS10070	COG1072	(Pantothenic acid kinase))
SXIM_RS10075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SXIM_RS10080	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SXIM_RS10085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SXIM_RS10090	COG0488	(ABC) transporter
SXIM_RS10115	COG0101	tRNA pseudouridine synthase activity
SXIM_RS10120	COG0203	ribosomal protein L17
SXIM_RS10125	COG0202	RNA polymerase activity
SXIM_RS10135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SXIM_RS10140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SXIM_RS10145	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SXIM_RS10150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SXIM_RS10155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SXIM_RS10165	COG0563	adenylate kinase activity
SXIM_RS10175	COG0200	Binds to the 23S rRNA
SXIM_RS10185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SXIM_RS10190	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SXIM_RS10195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SXIM_RS10200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SXIM_RS10205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SXIM_RS10210	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SXIM_RS10215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SXIM_RS10220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SXIM_RS10225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SXIM_RS10230	COG0255	Belongs to the universal ribosomal protein uL29 family
SXIM_RS10235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SXIM_RS10240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SXIM_RS10245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SXIM_RS10250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SXIM_RS10255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SXIM_RS10260	COG0089	rRNA binding
SXIM_RS10265	COG0088	Forms part of the polypeptide exit tunnel
SXIM_RS10270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SXIM_RS10275	COG0051	transcription antitermination factor activity, RNA binding
SXIM_RS10280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SXIM_RS10290	COG3279	Response regulator of the LytR AlgR family
SXIM_RS10295	COG3275	phosphorelay sensor kinase activity
SXIM_RS10305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SXIM_RS10315	COG1653	transport
SXIM_RS10325	COG1175	transmembrane transport
SXIM_RS10330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SXIM_RS10340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SXIM_RS10345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SXIM_RS10350	COG0049	tRNA binding
SXIM_RS10355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SXIM_RS10360	COG1316	TRANSCRIPTIONal
SXIM_RS10365	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SXIM_RS10370	COG0085	RNA polymerase activity
SXIM_RS10375	COG0222	ribosome binding
SXIM_RS10380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SXIM_RS10390	COG0081	regulation of translation
SXIM_RS10395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SXIM_RS10410	COG2205	protein histidine kinase activity
SXIM_RS10410	COG2972	Histidine kinase
SXIM_RS10415	COG0745	RESPONSE REGULATOR receiver
SXIM_RS10420	COG0250	Participates in transcription elongation, termination and antitermination
SXIM_RS10435	COG0436	Aminotransferase
SXIM_RS10440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SXIM_RS10450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SXIM_RS10455	COG0477	Major facilitator Superfamily
SXIM_RS10470	COG2030	dehydratase
SXIM_RS10475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SXIM_RS10495	COG0702	epimerase
SXIM_RS10600	COG2813	Specifically methylates the guanine in position
SXIM_RS10605	COG2318	DinB family
SXIM_RS10620	COG1666	GTP binding
SXIM_RS10630	COG3304	Inner membrane component domain
SXIM_RS10635	COG0501	Belongs to the peptidase M48B family
SXIM_RS10640	COG1007	ATP synthesis coupled electron transport
SXIM_RS10655	COG0713	ATP synthesis coupled electron transport
SXIM_RS10660	COG0839	Belongs to the complex I subunit 6 family
SXIM_RS10665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SXIM_RS10670	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SXIM_RS10680	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SXIM_RS10695	COG4585	Histidine kinase
SXIM_RS10705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SXIM_RS10705	COG0674	pyruvate-flavodoxin oxidoreductase activity
SXIM_RS10710	COG1013	pyruvate-flavodoxin oxidoreductase activity
SXIM_RS10745	COG0142	geranyltranstransferase activity
SXIM_RS10765	COG1007	ATP synthesis coupled electron transport
SXIM_RS10775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SXIM_RS10780	COG0713	ATP synthesis coupled electron transport
SXIM_RS10790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SXIM_RS10795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SXIM_RS10800	COG1034	ATP synthesis coupled electron transport
SXIM_RS10805	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SXIM_RS10815	COG0649	NAD binding
SXIM_RS10820	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SXIM_RS10825	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SXIM_RS10855	COG0384	phenazine biosynthesis protein PhzF
SXIM_RS10870	COG1131	(ABC) transporter
SXIM_RS10885	COG2226	methyltransferase
SXIM_RS10900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SXIM_RS10905	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SXIM_RS10905	COG0515	serine threonine protein kinase
SXIM_RS10910	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SXIM_RS10915	COG1278	Cold shock
SXIM_RS10930	COG1301	dicarboxylic acid transport
SXIM_RS10945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SXIM_RS10955	COG0163	prenyltransferase activity
SXIM_RS10965	COG0705	Rhomboid family
SXIM_RS10975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SXIM_RS10980	COG0515	serine threonine protein kinase
SXIM_RS10980	COG2815	serine threonine protein kinase
SXIM_RS10985	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SXIM_RS11015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SXIM_RS11015	COG0515	serine threonine protein kinase
SXIM_RS11095	COG0640	Transcriptional regulator
SXIM_RS11135	COG0129	dihydroxy-acid dehydratase activity
SXIM_RS11145	COG0248	Ppx GppA phosphatase
SXIM_RS11155	COG0842	Transport permease protein
SXIM_RS11155	COG1129	ABC transporter
SXIM_RS11160	COG1082	Xylose isomerase domain protein TIM barrel
SXIM_RS11165	COG1309	transcriptional regulator
SXIM_RS11180	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SXIM_RS11190	COG1194	a g-specific adenine glycosylase
SXIM_RS11195	COG2205	protein histidine kinase activity
SXIM_RS11200	COG0745	RESPONSE REGULATOR receiver
SXIM_RS11205	COG0577	efflux transmembrane transporter activity
SXIM_RS11210	COG0577	efflux transmembrane transporter activity
SXIM_RS11215	COG1136	(ABC) transporter
SXIM_RS11230	COG0519	Catalyzes the synthesis of GMP from XMP
SXIM_RS11260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SXIM_RS11280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SXIM_RS11295	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SXIM_RS11305	COG2197	response regulator
SXIM_RS11320	COG0649	NAD binding
SXIM_RS11345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SXIM_RS11350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SXIM_RS11365	COG1174	glycine betaine transport
SXIM_RS11390	COG0302	gtp cyclohydrolase
SXIM_RS11405	COG0037	tRNA processing
SXIM_RS11415	COG2027	D-alanyl-D-alanine carboxypeptidase
SXIM_RS11420	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SXIM_RS11435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SXIM_RS11440	COG1595	DNA-templated transcription, initiation
SXIM_RS11485	COG1131	(ABC) transporter
SXIM_RS11490	COG2197	response regulator
SXIM_RS11495	COG4585	Histidine kinase
SXIM_RS11510	COG0739	heme binding
SXIM_RS11515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SXIM_RS11520	COG1993	acr, cog1993
SXIM_RS11525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SXIM_RS11530	COG1077	Cell shape determining protein MreB Mrl
SXIM_RS11575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SXIM_RS11580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SXIM_RS11590	COG0254	rRNA binding
SXIM_RS11600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SXIM_RS11650	COG0179	Fumarylacetoacetate (FAA) hydrolase
SXIM_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS11680	COG2124	cytochrome p450
SXIM_RS11745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SXIM_RS11750	COG1121	(ABC) transporter
SXIM_RS11805	COG3629	intracellular signal transduction
SXIM_RS11805	COG3903	Transcriptional regulator
SXIM_RS11840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SXIM_RS11855	COG4336	lyase activity
SXIM_RS11860	COG0477	Major facilitator Superfamily
SXIM_RS11870	COG1984	allophanate hydrolase subunit 2
SXIM_RS11880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SXIM_RS11885	COG1802	Transcriptional regulator
SXIM_RS11890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SXIM_RS11930	COG2207	Transcriptional regulator
SXIM_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS11965	COG1063	alcohol dehydrogenase
SXIM_RS11990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SXIM_RS12000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SXIM_RS12005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SXIM_RS12005	COG1754	DNA topoisomerase type I activity
SXIM_RS12025	COG2264	protein methyltransferase activity
SXIM_RS12040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SXIM_RS12045	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SXIM_RS12050	COG2172	sigma factor antagonist activity
SXIM_RS12055	COG1366	Belongs to the anti-sigma-factor antagonist family
SXIM_RS12060	COG1205	dead DEAH box helicase
SXIM_RS12060	COG1111	helicase
SXIM_RS12120	COG0659	secondary active sulfate transmembrane transporter activity
SXIM_RS12125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SXIM_RS12135	COG0596	Alpha beta hydrolase
SXIM_RS12165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SXIM_RS12180	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SXIM_RS12190	COG0512	Glutamine amidotransferase of anthranilate synthase
SXIM_RS12195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SXIM_RS12200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SXIM_RS12205	COG0134	indole-3-glycerol-phosphate synthase activity
SXIM_RS12240	COG2368	4-hydroxyphenylacetate
SXIM_RS12250	COG2207	Transcriptional regulator
SXIM_RS12290	COG1408	metallophosphoesterase
SXIM_RS12300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SXIM_RS12300	COG4499	WXG100 protein secretion system (Wss), protein YukC
SXIM_RS12335	COG1595	DNA-templated transcription, initiation
SXIM_RS12345	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SXIM_RS12375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SXIM_RS12380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SXIM_RS12430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SXIM_RS12490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SXIM_RS12510	COG0673	inositol 2-dehydrogenase activity
SXIM_RS12520	COG1172	Belongs to the binding-protein-dependent transport system permease family
SXIM_RS12525	COG1129	ABC transporter
SXIM_RS12530	COG1940	carbohydrate kinase activity
SXIM_RS12535	COG1278	Cold shock
SXIM_RS12555	COG0667	Aldo Keto reductase
SXIM_RS12560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SXIM_RS12565	COG1914	H( )-stimulated, divalent metal cation uptake system
SXIM_RS12570	COG3395	kinase activity
SXIM_RS12575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SXIM_RS12580	COG1349	DNA-binding transcription factor activity
SXIM_RS12585	COG2409	Drug exporters of the RND superfamily
SXIM_RS12610	COG4221	oxidoreductase activity
SXIM_RS12620	COG3401	FG-GAP repeat protein
SXIM_RS12645	COG1674	ftsk spoiiie
SXIM_RS12645	COG0433	COG0433 Predicted ATPase
SXIM_RS12670	COG0464	growth
SXIM_RS12695	COG2234	aminopeptidase activity
SXIM_RS12710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SXIM_RS12730	COG1191	sigma factor activity
SXIM_RS12735	COG1191	sigma factor activity
SXIM_RS12785	COG0318	PFAM AMP-dependent synthetase and ligase
SXIM_RS12790	COG1595	DNA-templated transcription, initiation
SXIM_RS12815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SXIM_RS12830	COG0653	protein targeting
SXIM_RS12845	COG0006	proline dipeptidase activity
SXIM_RS12860	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SXIM_RS12865	COG1733	regulation of RNA biosynthetic process
SXIM_RS12870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SXIM_RS12880	COG1595	DNA-templated transcription, initiation
SXIM_RS12905	COG1999	signal sequence binding
SXIM_RS12915	COG2372	response to copper ion
SXIM_RS12920	COG2837	iron assimilation
SXIM_RS12930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SXIM_RS12935	COG0561	phosphatase activity
SXIM_RS12970	COG0561	phosphatase activity
SXIM_RS12985	COG1609	Transcriptional regulator
SXIM_RS12990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SXIM_RS12995	COG1271	oxidase subunit
SXIM_RS13000	COG1294	oxidase, subunit
SXIM_RS13005	COG4988	ABC transporter
SXIM_RS13030	COG3617	BRO family, N-terminal domain
SXIM_RS13035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SXIM_RS13050	COG0662	Cupin 2, conserved barrel domain protein
SXIM_RS13055	COG1950	PFAM Membrane protein of
SXIM_RS13060	COG0626	cystathionine gamma-synthase activity
SXIM_RS13100	COG0477	Major facilitator Superfamily
SXIM_RS13110	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS13120	COG4978	Transcriptional regulator
SXIM_RS13120	COG0789	Transcriptional regulator
SXIM_RS13135	COG0305	Participates in initiation and elongation during chromosome replication
SXIM_RS13135	COG1372	Participates in initiation and elongation during chromosome replication
SXIM_RS13140	COG0534	Mate efflux family protein
SXIM_RS13145	COG0359	binds to the 23S rRNA
SXIM_RS13150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SXIM_RS13155	COG0629	single-stranded DNA binding
SXIM_RS13160	COG0360	Binds together with S18 to 16S ribosomal RNA
SXIM_RS13180	COG1260	myo-inositol-1-phosphate synthase
SXIM_RS13190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SXIM_RS13205	COG0617	tRNA 3'-terminal CCA addition
SXIM_RS13225	COG1595	DNA-templated transcription, initiation
SXIM_RS13235	COG0492	ferredoxin-NADP+ reductase activity
SXIM_RS13240	COG3118	belongs to the thioredoxin family
SXIM_RS13250	COG1192	Involved in chromosome partitioning
SXIM_RS13255	COG0357	Ribosomal RNA small subunit methyltransferase G
SXIM_RS13265	COG0706	membrane insertase activity
SXIM_RS13270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SXIM_RS13280	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SXIM_RS13290	COG0592	DNA-directed DNA polymerase activity
SXIM_RS13295	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SXIM_RS13300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SXIM_RS13305	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SXIM_RS13315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SXIM_RS13335	COG1309	transcriptional regulator
SXIM_RS13365	COG3764	Sortase (surface protein transpeptidase)
SXIM_RS13370	COG3764	Sortase (surface protein transpeptidase)
SXIM_RS13395	COG0705	Rhomboid family
SXIM_RS13410	COG0515	serine threonine protein kinase
SXIM_RS13415	COG0768	penicillin binding
SXIM_RS13430	COG1716	ATPase activity
SXIM_RS13435	COG1716	ATPase activity
SXIM_RS13460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SXIM_RS13480	COG0438	transferase activity, transferring glycosyl groups
SXIM_RS13510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SXIM_RS13515	COG1733	regulation of RNA biosynthetic process
SXIM_RS13525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SXIM_RS13545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SXIM_RS13555	COG2226	methyltransferase
SXIM_RS13570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SXIM_RS13575	COG1741	Belongs to the pirin family
SXIM_RS13585	COG1960	acyl-CoA dehydrogenase activity
SXIM_RS13635	COG1674	ftsk spoiiie
SXIM_RS13645	COG1362	aminopeptidase activity
SXIM_RS13655	COG0515	serine threonine protein kinase
SXIM_RS13660	COG0515	serine threonine protein kinase
SXIM_RS13675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SXIM_RS13680	COG1414	Transcriptional regulator
SXIM_RS13700	COG0022	dehydrogenase e1 component
SXIM_RS13705	COG0508	dehydrogenase complex catalyzes the overall conversion of
SXIM_RS13720	COG1136	(ABC) transporter
SXIM_RS13720	COG4591	ABC-type transport system involved in lipoprotein release permease component
SXIM_RS13740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SXIM_RS13750	COG0746	molybdenum cofactor guanylyltransferase activity
SXIM_RS13775	COG1522	sequence-specific DNA binding
SXIM_RS13785	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
SXIM_RS13845	COG3396	Phenylacetate-CoA oxygenase
SXIM_RS13850	COG3460	Phenylacetate-CoA oxygenase
SXIM_RS13855	COG3396	Phenylacetate-CoA oxygenase
SXIM_RS13860	COG2151	metal-sulfur cluster biosynthetic enzyme
SXIM_RS13865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SXIM_RS13945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SXIM_RS13950	COG0076	glutamate decarboxylase activity
SXIM_RS13965	COG2197	response regulator
SXIM_RS13980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SXIM_RS14045	COG1401	restriction endodeoxyribonuclease activity
SXIM_RS14055	COG1120	ATPase activity
SXIM_RS14080	COG2508	Transcriptional regulator
SXIM_RS14080	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SXIM_RS14080	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SXIM_RS14080	COG2508	Transcriptional regulator
SXIM_RS14085	COG0477	Major facilitator Superfamily
SXIM_RS14110	COG3693	PFAM glycoside hydrolase, family 10
SXIM_RS14125	COG0717	Belongs to the dCTP deaminase family
SXIM_RS14135	COG2181	nitrate reductase activity
SXIM_RS14135	COG0247	lactate metabolic process
SXIM_RS14140	COG3189	MarR family transcriptional regulator
SXIM_RS14145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SXIM_RS14155	COG0443	Heat shock 70 kDa protein
SXIM_RS14160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SXIM_RS14165	COG0484	heat shock protein binding
SXIM_RS14170	COG0789	Transcriptional regulator
SXIM_RS14175	COG0596	Alpha beta hydrolase
SXIM_RS14185	COG0671	phosphoesterase, PA-phosphatase related
SXIM_RS14210	COG0542	response to heat
SXIM_RS14225	COG4608	Belongs to the ABC transporter superfamily
SXIM_RS14235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SXIM_RS14270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SXIM_RS14275	COG0191	fructose-bisphosphate aldolase activity
SXIM_RS14285	COG3483	tryptophan 2,3-dioxygenase activity
SXIM_RS14315	COG0393	Putative heavy-metal-binding
SXIM_RS14330	COG3559	Exporter of polyketide antibiotics
SXIM_RS14335	COG1131	(ABC) transporter
SXIM_RS14350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SXIM_RS14385	COG1802	Transcriptional regulator
SXIM_RS14400	COG0151	Belongs to the GarS family
SXIM_RS14415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SXIM_RS14440	COG2197	response regulator
SXIM_RS14480	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SXIM_RS14485	COG0047	phosphoribosylformylglycinamidine synthase activity
SXIM_RS14490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SXIM_RS14500	COG0640	Transcriptional regulator
SXIM_RS14535	COG0318	PFAM AMP-dependent synthetase and ligase
SXIM_RS14565	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SXIM_RS14565	COG0515	serine threonine protein kinase
SXIM_RS14580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SXIM_RS14610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SXIM_RS14620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SXIM_RS14640	COG1643	Atp-dependent helicase
SXIM_RS14660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SXIM_RS14680	COG0513	Belongs to the DEAD box helicase family
SXIM_RS14705	COG1196	nuclear chromosome segregation
SXIM_RS14705	COG0741	lytic transglycosylase activity
SXIM_RS14705	COG0739	heme binding
SXIM_RS14715	COG0270	DNA (cytosine-5-)-methyltransferase activity
SXIM_RS14755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SXIM_RS14815	COG0123	including yeast histone deacetylase and acetoin utilization protein
SXIM_RS14850	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SXIM_RS14855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SXIM_RS14860	COG0181	hydroxymethylbilane synthase activity
SXIM_RS14865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SXIM_RS14865	COG1648	precorrin-2 dehydrogenase activity
SXIM_RS14870	COG0113	porphobilinogen synthase activity
SXIM_RS14900	COG0018	arginyl-trna synthetase
SXIM_RS14905	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SXIM_RS14930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SXIM_RS14940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SXIM_RS14945	COG0406	alpha-ribazole phosphatase activity
SXIM_RS14950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SXIM_RS14955	COG0785	Cytochrome C biogenesis protein
SXIM_RS14960	COG1333	cytochrome c biogenesis protein
SXIM_RS14965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SXIM_RS14975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SXIM_RS14985	COG0789	Transcriptional regulator
SXIM_RS15035	COG0702	epimerase
SXIM_RS15055	COG1404	Belongs to the peptidase S8 family
SXIM_RS15060	COG1404	Belongs to the peptidase S8 family
SXIM_RS15080	COG3629	intracellular signal transduction
SXIM_RS15085	COG1595	DNA-templated transcription, initiation
SXIM_RS15090	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SXIM_RS15120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SXIM_RS15125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SXIM_RS15145	COG0010	Belongs to the arginase family
SXIM_RS15155	COG2814	Major facilitator Superfamily
SXIM_RS15170	COG1196	nuclear chromosome segregation
SXIM_RS15170	COG0741	lytic transglycosylase activity
SXIM_RS15170	COG0739	heme binding
SXIM_RS15185	COG1937	Protein conserved in bacteria
SXIM_RS15200	COG0581	inorganic phosphate transmembrane transporter activity
SXIM_RS15205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SXIM_RS15250	COG0789	Transcriptional regulator
SXIM_RS15260	COG4585	Histidine kinase
SXIM_RS15265	COG2197	response regulator
SXIM_RS15280	COG2409	Drug exporters of the RND superfamily
SXIM_RS15290	COG0546	phosphoglycolate phosphatase activity
SXIM_RS15305	COG4552	Acetyltransferase involved in intracellular survival and related
SXIM_RS15315	COG1490	D-aminoacyl-tRNA deacylase activity
SXIM_RS15335	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS15340	COG3485	protocatechuate 3,4-dioxygenase
SXIM_RS15370	COG0745	RESPONSE REGULATOR receiver
SXIM_RS15375	COG1609	Transcriptional regulator
SXIM_RS15385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SXIM_RS15405	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SXIM_RS15415	COG0737	Belongs to the 5'-nucleotidase family
SXIM_RS15420	COG0456	acetyltransferase
SXIM_RS15430	COG0494	nUDIX hydrolase
SXIM_RS15430	COG0406	alpha-ribazole phosphatase activity
SXIM_RS15440	COG0438	transferase activity, transferring glycosyl groups
SXIM_RS15460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SXIM_RS15470	COG1335	isochorismatase
SXIM_RS15495	COG3290	protein histidine kinase activity
SXIM_RS15500	COG0588	phosphoglycerate mutase activity
SXIM_RS15505	COG4585	Histidine kinase
SXIM_RS15515	COG5002	protein histidine kinase activity
SXIM_RS15530	COG1329	Transcriptional regulator
SXIM_RS15535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SXIM_RS15540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SXIM_RS15550	COG0215	cysteine-tRNA ligase activity
SXIM_RS15555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SXIM_RS15565	COG0596	Alpha beta hydrolase
SXIM_RS15585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SXIM_RS15595	COG3842	ATPase activity
SXIM_RS15615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SXIM_RS15650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SXIM_RS15660	COG3300	MHYT domain
SXIM_RS15660	COG5001	Diguanylate cyclase
SXIM_RS15670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SXIM_RS15675	COG1940	carbohydrate kinase activity
SXIM_RS15675	COG1846	Transcriptional regulator
SXIM_RS15695	COG1877	trehalose-phosphatase activity
SXIM_RS15710	COG0463	Glycosyl transferase, family 2
SXIM_RS15725	COG1278	Cold shock
SXIM_RS15735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SXIM_RS15740	COG1737	Transcriptional regulator
SXIM_RS15770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SXIM_RS15775	COG0745	RESPONSE REGULATOR receiver
SXIM_RS15780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SXIM_RS15790	COG0581	inorganic phosphate transmembrane transporter activity
SXIM_RS15795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SXIM_RS15820	COG0739	heme binding
SXIM_RS15820	COG0741	lytic transglycosylase activity
SXIM_RS15820	COG1196	nuclear chromosome segregation
SXIM_RS15825	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
SXIM_RS15840	COG1061	Type III restriction enzyme res subunit
SXIM_RS15850	COG3973	AAA domain
SXIM_RS15865	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SXIM_RS15870	COG1396	sequence-specific DNA binding
SXIM_RS15910	COG1278	Cold shock
SXIM_RS15915	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SXIM_RS15920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SXIM_RS15930	COG2814	Major facilitator Superfamily
SXIM_RS15965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SXIM_RS15980	COG1846	Transcriptional regulator
SXIM_RS15985	COG2814	Major facilitator Superfamily
SXIM_RS16000	COG0667	Aldo Keto reductase
SXIM_RS16070	COG1309	transcriptional regulator
SXIM_RS16080	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SXIM_RS16120	COG0277	FAD linked oxidase domain protein
SXIM_RS16120	COG0247	lactate metabolic process
SXIM_RS16235	COG1136	(ABC) transporter
SXIM_RS16255	COG2226	methyltransferase
SXIM_RS16270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SXIM_RS16275	COG0259	pyridoxamine-phosphate oxidase activity
SXIM_RS16280	COG4821	SIS domain
SXIM_RS16355	COG2072	flavoprotein involved in K transport
SXIM_RS16365	COG0515	serine threonine protein kinase
SXIM_RS16365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SXIM_RS16400	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SXIM_RS16465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SXIM_RS16470	COG0459	protein refolding
SXIM_RS16480	COG4221	oxidoreductase activity
SXIM_RS16490	COG2197	response regulator
SXIM_RS16495	COG1595	DNA-templated transcription, initiation
SXIM_RS16505	COG0516	GMP reductase activity
SXIM_RS16525	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SXIM_RS16530	COG0515	serine threonine protein kinase
SXIM_RS16530	COG2815	serine threonine protein kinase
SXIM_RS16540	COG1012	belongs to the aldehyde dehydrogenase family
SXIM_RS16555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SXIM_RS16555	COG0519	Catalyzes the synthesis of GMP from XMP
SXIM_RS16565	COG2197	response regulator
SXIM_RS16620	COG0454	-acetyltransferase
SXIM_RS16620	COG0456	acetyltransferase
SXIM_RS16635	COG1902	pentaerythritol trinitrate reductase activity
SXIM_RS16645	COG1131	(ABC) transporter
SXIM_RS16660	COG0640	Transcriptional regulator
SXIM_RS16700	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SXIM_RS16720	COG2197	response regulator
SXIM_RS16725	COG3851	Histidine kinase
SXIM_RS16735	COG1131	(ABC) transporter
SXIM_RS16765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SXIM_RS16770	COG0045	succinate-CoA ligase (ADP-forming) activity
SXIM_RS16790	COG0596	Alpha beta hydrolase
SXIM_RS16820	COG0138	bifunctional purine biosynthesis protein purh
SXIM_RS16840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SXIM_RS16895	COG0039	L-malate dehydrogenase activity
SXIM_RS16900	COG0538	isocitrate dehydrogenase activity
SXIM_RS16905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SXIM_RS16910	COG0180	Tryptophanyl-tRNA synthetase
SXIM_RS16925	COG1686	Belongs to the peptidase S11 family
SXIM_RS16930	COG1408	metallophosphoesterase
SXIM_RS16950	COG0477	Major facilitator Superfamily
SXIM_RS16960	COG0277	FAD linked oxidase domain protein
SXIM_RS16980	COG4941	Belongs to the sigma-70 factor family
SXIM_RS17010	COG2197	response regulator
SXIM_RS17025	COG2362	D-Aminopeptidase
SXIM_RS17035	COG1309	transcriptional regulator
SXIM_RS17040	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SXIM_RS17045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SXIM_RS17100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SXIM_RS17105	COG1053	succinate dehydrogenase
SXIM_RS17115	COG2009	succinate dehydrogenase
SXIM_RS17130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SXIM_RS17130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SXIM_RS17170	COG1083	cytidylyl-transferase
SXIM_RS17175	COG2089	acid synthase
SXIM_RS17190	COG1902	pentaerythritol trinitrate reductase activity
SXIM_RS17195	COG1473	amidohydrolase
SXIM_RS17195	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SXIM_RS17200	COG1744	ABC transporter substrate-binding protein PnrA-like
SXIM_RS17205	COG3845	ABC transporter
SXIM_RS17210	COG4603	Belongs to the binding-protein-dependent transport system permease family
SXIM_RS17215	COG1079	Belongs to the binding-protein-dependent transport system permease family
SXIM_RS17230	COG2239	Acts as a magnesium transporter
SXIM_RS17245	COG3265	gluconokinase activity
SXIM_RS17250	COG2610	gluconate transmembrane transporter activity
SXIM_RS17280	COG1733	regulation of RNA biosynthetic process
SXIM_RS17300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SXIM_RS17310	COG2814	Major facilitator Superfamily
SXIM_RS17315	COG0583	DNA-binding transcription factor activity
SXIM_RS17320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SXIM_RS17340	COG2205	protein histidine kinase activity
SXIM_RS17345	COG0745	RESPONSE REGULATOR receiver
SXIM_RS17350	COG1595	DNA-templated transcription, initiation
SXIM_RS17365	COG1012	belongs to the aldehyde dehydrogenase family
SXIM_RS17370	COG1012	belongs to the aldehyde dehydrogenase family
SXIM_RS17390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SXIM_RS17400	COG1733	regulation of RNA biosynthetic process
SXIM_RS17440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SXIM_RS17475	COG4770	biotin carboxylase activity
SXIM_RS17485	COG0424	maF-like protein
SXIM_RS17510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SXIM_RS17520	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SXIM_RS17525	COG1024	Enoyl-CoA hydratase
SXIM_RS17535	COG2986	histidine ammonia-lyase
SXIM_RS17550	COG1376	ErfK ybiS ycfS ynhG family protein
SXIM_RS17560	COG0740	serine-type endopeptidase activity
SXIM_RS17565	COG0740	serine-type endopeptidase activity
SXIM_RS17575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SXIM_RS17595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SXIM_RS17610	COG3629	intracellular signal transduction
SXIM_RS17610	COG3903	Transcriptional regulator
SXIM_RS17620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SXIM_RS17630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SXIM_RS17640	COG1131	(ABC) transporter
SXIM_RS17655	COG0604	alcohol dehydrogenase
SXIM_RS17655	COG3321	synthase
SXIM_RS17660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SXIM_RS17680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SXIM_RS17690	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SXIM_RS17695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SXIM_RS17710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SXIM_RS17735	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SXIM_RS17755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SXIM_RS17790	COG1132	(ABC) transporter
SXIM_RS17805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SXIM_RS17830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SXIM_RS17840	COG2197	response regulator
SXIM_RS17885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SXIM_RS17920	COG0154	amidase activity
SXIM_RS17925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SXIM_RS17945	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SXIM_RS17990	COG2894	cell division
SXIM_RS18035	COG2885	chlorophyll binding
SXIM_RS18040	COG0515	serine threonine protein kinase
SXIM_RS18040	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SXIM_RS18045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SXIM_RS18050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SXIM_RS18055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SXIM_RS18090	COG1136	(ABC) transporter
SXIM_RS18115	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SXIM_RS18115	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SXIM_RS18120	COG0114	fumarate hydratase activity
SXIM_RS18135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SXIM_RS18140	COG0450	alkyl hydroperoxide reductase
SXIM_RS18180	COG0778	Nitroreductase
SXIM_RS18185	COG1722	exodeoxyribonuclease VII activity
SXIM_RS18190	COG1570	exodeoxyribonuclease VII activity
SXIM_RS18195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SXIM_RS18205	COG0012	GTP binding
SXIM_RS18215	COG1846	Transcriptional regulator
SXIM_RS18220	COG2409	Drug exporters of the RND superfamily
SXIM_RS18255	COG2124	cytochrome p450
SXIM_RS18260	COG0456	acetyltransferase
SXIM_RS18290	COG1217	gtp-binding protein TYPA
SXIM_RS18295	COG4166	transmembrane transport
SXIM_RS18300	COG0601	transmembrane transport
SXIM_RS18305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SXIM_RS18315	COG4608	Belongs to the ABC transporter superfamily
SXIM_RS18320	COG4166	transmembrane transport
SXIM_RS18325	COG0601	transmembrane transport
SXIM_RS18330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SXIM_RS18335	COG0444	Belongs to the ABC transporter superfamily
SXIM_RS18340	COG4608	Belongs to the ABC transporter superfamily
SXIM_RS18345	COG2267	carboxylic ester hydrolase activity
SXIM_RS18350	COG0604	alcohol dehydrogenase
SXIM_RS18350	COG3321	synthase
SXIM_RS18385	COG4608	Belongs to the ABC transporter superfamily
SXIM_RS18390	COG0444	Belongs to the ABC transporter superfamily
SXIM_RS18395	COG0601	transmembrane transport
SXIM_RS18400	COG0747	negative chemotaxis
SXIM_RS18405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SXIM_RS18440	COG0477	Major facilitator Superfamily
SXIM_RS18445	COG1309	transcriptional regulator
SXIM_RS18455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SXIM_RS18470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SXIM_RS18480	COG1024	Enoyl-CoA hydratase
SXIM_RS18495	COG1595	DNA-templated transcription, initiation
SXIM_RS18505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SXIM_RS18510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SXIM_RS18545	COG0737	Belongs to the 5'-nucleotidase family
SXIM_RS18595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SXIM_RS18595	COG0596	Alpha beta hydrolase
SXIM_RS18625	COG0596	Alpha beta hydrolase
SXIM_RS18630	COG0596	Alpha beta hydrolase
SXIM_RS18755	COG3480	Lon protease (S16) C-terminal proteolytic domain
SXIM_RS18765	COG1615	UPF0182 protein
SXIM_RS18780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SXIM_RS18790	COG1309	transcriptional regulator
SXIM_RS18800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SXIM_RS18815	COG1960	acyl-CoA dehydrogenase activity
SXIM_RS18830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SXIM_RS18835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SXIM_RS18840	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SXIM_RS18845	COG1120	ATPase activity
SXIM_RS18855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SXIM_RS18860	COG0589	response to stress
SXIM_RS18870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SXIM_RS18920	COG1162	GTPase activity
SXIM_RS18945	COG2197	response regulator
SXIM_RS18950	COG4585	Histidine kinase
SXIM_RS18960	COG0483	inositol monophosphate 1-phosphatase activity
SXIM_RS18965	COG0753	catalase activity
SXIM_RS18980	COG1946	Acyl-CoA thioesterase
SXIM_RS19005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SXIM_RS19020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SXIM_RS19035	COG1051	belongs to the nudix hydrolase family
SXIM_RS19050	COG0673	inositol 2-dehydrogenase activity
SXIM_RS19120	COG0515	serine threonine protein kinase
SXIM_RS19155	COG2223	nitrite transmembrane transporter activity
SXIM_RS19180	COG0776	regulation of translation
SXIM_RS19185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SXIM_RS19190	COG1678	Uncharacterized ACR, COG1678
SXIM_RS19200	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SXIM_RS19210	COG2080	2 iron, 2 sulfur cluster binding
SXIM_RS19215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SXIM_RS19220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SXIM_RS19235	COG1819	glycosyl
SXIM_RS19240	COG2814	Major facilitator Superfamily
SXIM_RS19255	COG3480	Lon protease (S16) C-terminal proteolytic domain
SXIM_RS19260	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SXIM_RS19300	COG1335	isochorismatase
SXIM_RS19310	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SXIM_RS19320	COG1115	amino acid carrier protein
SXIM_RS19340	COG0772	Belongs to the SEDS family
SXIM_RS19350	COG1234	tRNA 3'-trailer cleavage
SXIM_RS19355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SXIM_RS19360	COG1609	Transcriptional regulator
SXIM_RS19365	COG1653	transport
SXIM_RS19370	COG1175	transmembrane transport
SXIM_RS19375	COG0395	ABC-type sugar transport system, permease component
SXIM_RS19380	COG1874	Beta-galactosidase
SXIM_RS19385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SXIM_RS19420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SXIM_RS19425	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SXIM_RS19435	COG2733	membrane
SXIM_RS19475	COG1126	abc transporter atp-binding protein
SXIM_RS19480	COG0765	amino acid transport
SXIM_RS19485	COG0765	amino acid transport
SXIM_RS19495	COG1404	Belongs to the peptidase S8 family
SXIM_RS19505	COG0154	amidase activity
SXIM_RS19510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SXIM_RS19560	COG0406	alpha-ribazole phosphatase activity
SXIM_RS19590	COG5002	protein histidine kinase activity
SXIM_RS19590	COG2205	protein histidine kinase activity
SXIM_RS19590	COG0784	Response regulator, receiver
SXIM_RS19630	COG5297	Belongs to the glycosyl hydrolase family 6
SXIM_RS19635	COG5297	Belongs to the glycosyl hydrolase family 6
SXIM_RS19635	COG4733	cellulase activity
SXIM_RS19645	COG5297	Belongs to the glycosyl hydrolase family 6
SXIM_RS19650	COG2135	peptidase activity
SXIM_RS19655	COG1595	DNA-templated transcription, initiation
SXIM_RS19660	COG5662	AntiSigma factor
SXIM_RS19680	COG0242	peptide deformylase activity
SXIM_RS19715	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SXIM_RS19735	COG1966	Carbon starvation protein
SXIM_RS19740	COG2188	Transcriptional regulator
SXIM_RS19750	COG1175	transmembrane transport
SXIM_RS19755	COG0395	ABC-type sugar transport system, permease component
SXIM_RS19760	COG1472	Belongs to the glycosyl hydrolase 3 family
SXIM_RS19765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SXIM_RS19780	COG1597	lipid kinase activity
SXIM_RS19800	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SXIM_RS19845	COG4106	trans-aconitate 2-methyltransferase activity
SXIM_RS19850	COG0281	malic enzyme
SXIM_RS19855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SXIM_RS19860	COG0765	amino acid transport
SXIM_RS19870	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS19895	COG0604	alcohol dehydrogenase
SXIM_RS19900	COG2186	Transcriptional regulator
SXIM_RS19910	COG2376	Dihydroxyacetone kinase
SXIM_RS19915	COG0698	ribose 5-phosphate isomerase
SXIM_RS19920	COG0149	triose-phosphate isomerase activity
SXIM_RS19925	COG1082	Xylose isomerase domain protein TIM barrel
SXIM_RS19930	COG2084	Dehydrogenase
SXIM_RS19965	COG2255	four-way junction helicase activity
SXIM_RS20020	COG2205	protein histidine kinase activity
SXIM_RS20065	COG2391	methyltransferase activity
SXIM_RS20070	COG1309	transcriptional regulator
SXIM_RS20080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SXIM_RS20080	COG1796	DNA polymerase
SXIM_RS20100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SXIM_RS20150	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SXIM_RS20155	COG1501	Belongs to the glycosyl hydrolase 31 family
SXIM_RS20170	COG1937	Protein conserved in bacteria
SXIM_RS20175	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SXIM_RS20230	COG2130	NADP-dependent
SXIM_RS20235	COG1233	COG1233 Phytoene dehydrogenase and related
SXIM_RS20255	COG0726	polysaccharide deacetylase
SXIM_RS20310	COG1132	(ABC) transporter
SXIM_RS20335	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SXIM_RS20340	COG3421	Type III restriction
SXIM_RS20365	COG2188	Transcriptional regulator
SXIM_RS20415	COG2201	protein-glutamate methylesterase activity
SXIM_RS20420	COG0018	arginyl-trna synthetase
SXIM_RS20425	COG0019	diaminopimelate decarboxylase activity
SXIM_RS20430	COG0460	homoserine dehydrogenase
SXIM_RS20435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SXIM_RS20440	COG0083	homoserine kinase activity
SXIM_RS20450	COG1316	TRANSCRIPTIONal
SXIM_RS20455	COG0254	rRNA binding
SXIM_RS20460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SXIM_RS20465	COG2890	protein-(glutamine-N5) methyltransferase activity
SXIM_RS20475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SXIM_RS20495	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SXIM_RS20500	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SXIM_RS20505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SXIM_RS20510	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SXIM_RS20515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SXIM_RS20520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SXIM_RS20525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SXIM_RS20540	COG2197	response regulator
SXIM_RS20580	COG2890	protein-(glutamine-N5) methyltransferase activity
SXIM_RS20600	COG1609	Transcriptional regulator
SXIM_RS20610	COG0747	negative chemotaxis
SXIM_RS20615	COG0601	transmembrane transport
SXIM_RS20620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SXIM_RS20625	COG0444	Belongs to the ABC transporter superfamily
SXIM_RS20630	COG4608	Belongs to the ABC transporter superfamily
SXIM_RS20640	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SXIM_RS20645	COG1250	3-hydroxyacyl-CoA dehydrogenase
SXIM_RS20660	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SXIM_RS20695	COG1131	(ABC) transporter
SXIM_RS20715	COG0183	Belongs to the thiolase family
SXIM_RS20740	COG1357	PFAM Pentapeptide repeats (8 copies)
SXIM_RS20745	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
SXIM_RS20810	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SXIM_RS20835	COG1309	transcriptional regulator
SXIM_RS20875	COG0745	RESPONSE REGULATOR receiver
SXIM_RS20880	COG2205	protein histidine kinase activity
SXIM_RS20905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SXIM_RS20905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SXIM_RS20910	COG2124	cytochrome p450
SXIM_RS20920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SXIM_RS20960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SXIM_RS20965	COG0857	belongs to the CobB CobQ family
SXIM_RS20965	COG0280	phosphate acetyltransferase
SXIM_RS20970	COG0205	6-phosphofructokinase activity
SXIM_RS20990	COG0789	Transcriptional regulator
SXIM_RS21000	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SXIM_RS21010	COG4257	antibiotic catabolic process
SXIM_RS21025	COG0242	peptide deformylase activity
SXIM_RS21035	COG4565	transcriptional regulatory protein
SXIM_RS21040	COG3290	protein histidine kinase activity
SXIM_RS21045	COG0471	metal ion transport
SXIM_RS21050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SXIM_RS21060	COG0366	Alpha amylase catalytic
SXIM_RS21065	COG0366	Alpha amylase catalytic
SXIM_RS21070	COG0747	negative chemotaxis
SXIM_RS21075	COG0601	transmembrane transport
SXIM_RS21080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SXIM_RS21085	COG0444	Belongs to the ABC transporter superfamily
SXIM_RS21095	COG0058	SHG alpha-glucan phosphorylase activity
SXIM_RS21100	COG1132	(ABC) transporter
SXIM_RS21105	COG1132	(ABC) transporter
SXIM_RS21125	COG1376	ErfK ybiS ycfS ynhG family protein
SXIM_RS21140	COG3629	intracellular signal transduction
SXIM_RS21140	COG3903	Transcriptional regulator
SXIM_RS21175	COG1131	(ABC) transporter
SXIM_RS21200	COG1473	amidohydrolase
SXIM_RS21255	COG1760	l-serine dehydratase
SXIM_RS21260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SXIM_RS21265	COG0509	glycine decarboxylation via glycine cleavage system
SXIM_RS21270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SXIM_RS21290	COG0783	Belongs to the Dps family
SXIM_RS21325	COG0482	sulfurtransferase activity
SXIM_RS21330	COG3655	Transcriptional regulator
SXIM_RS21355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SXIM_RS21365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SXIM_RS21370	COG0154	amidase activity
SXIM_RS21380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SXIM_RS21385	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SXIM_RS21385	COG1672	PFAM Archaeal ATPase
SXIM_RS21400	COG1672	PFAM Archaeal ATPase
SXIM_RS21400	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SXIM_RS21405	COG0667	Aldo Keto reductase
SXIM_RS21415	COG5001	Diguanylate cyclase
SXIM_RS21425	COG0440	acetolactate synthase activity
SXIM_RS21430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SXIM_RS21465	COG0506	proline dehydrogenase activity
SXIM_RS21470	COG1012	belongs to the aldehyde dehydrogenase family
SXIM_RS21480	COG0473	3-isopropylmalate dehydrogenase activity
SXIM_RS21485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SXIM_RS21490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SXIM_RS21495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SXIM_RS21515	COG2018	Roadblock/LC7 domain
SXIM_RS21535	COG2018	Roadblock/LC7 domain
SXIM_RS21550	COG0179	Fumarylacetoacetate (FAA) hydrolase
SXIM_RS21555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SXIM_RS21605	COG1414	Transcriptional regulator
SXIM_RS21610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SXIM_RS21615	COG0066	3-isopropylmalate dehydratase activity
SXIM_RS21625	COG0776	regulation of translation
SXIM_RS21635	COG1920	GTP binding
SXIM_RS21645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SXIM_RS21650	COG1181	Belongs to the D-alanine--D-alanine ligase family
SXIM_RS21670	COG0351	phosphomethylpyrimidine kinase
SXIM_RS21675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SXIM_RS21680	COG1461	Dihydroxyacetone kinase
SXIM_RS21705	COG0742	ribosomal rna small subunit methyltransferase
SXIM_RS21710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SXIM_RS21725	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SXIM_RS21730	COG0571	ribonuclease III activity
SXIM_RS21735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SXIM_RS21740	COG2340	Cysteine-rich secretory protein family
SXIM_RS21745	COG1254	Belongs to the acylphosphatase family
SXIM_RS21760	COG0477	Major facilitator Superfamily
SXIM_RS21790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SXIM_RS21800	COG0442	prolyl-tRNA aminoacylation
SXIM_RS21810	COG0228	four-way junction DNA binding
SXIM_RS21815	COG1837	Belongs to the UPF0109 family
SXIM_RS21820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SXIM_RS21825	COG0336	Belongs to the RNA methyltransferase TrmD family
SXIM_RS21830	COG0335	large ribosomal subunit rRNA binding
SXIM_RS21835	COG0681	Belongs to the peptidase S26 family
SXIM_RS21840	COG0681	Belongs to the peptidase S26 family
SXIM_RS21845	COG0681	Belongs to the peptidase S26 family
SXIM_RS21870	COG1191	sigma factor activity
SXIM_RS21885	COG0792	nuclease activity
SXIM_RS21890	COG0052	Belongs to the universal ribosomal protein uS2 family
SXIM_RS21895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SXIM_RS21900	COG0528	UMP kinase activity
SXIM_RS21905	COG0233	cytoplasmic translational termination
SXIM_RS21910	COG0575	Belongs to the CDS family
SXIM_RS21915	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SXIM_RS21925	COG1177	transmembrane transport
SXIM_RS21930	COG3842	ATPase activity
SXIM_RS21945	COG1136	(ABC) transporter
SXIM_RS21950	COG1012	belongs to the aldehyde dehydrogenase family
SXIM_RS21965	COG0584	glycerophosphoryl diester phosphodiesterase
SXIM_RS21970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SXIM_RS21995	COG2508	Transcriptional regulator
SXIM_RS22005	COG1012	belongs to the aldehyde dehydrogenase family
SXIM_RS22015	COG1472	Belongs to the glycosyl hydrolase 3 family
SXIM_RS22025	COG4209	transmembrane transport
SXIM_RS22030	COG0395	ABC-type sugar transport system, permease component
SXIM_RS22045	COG1609	Transcriptional regulator
SXIM_RS22065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SXIM_RS22070	COG0750	zinc metalloprotease
SXIM_RS22075	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SXIM_RS22085	COG0456	acetyltransferase
SXIM_RS22090	COG0442	prolyl-tRNA aminoacylation
SXIM_RS22110	COG0779	Required for maturation of 30S ribosomal subunits
SXIM_RS22125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SXIM_RS22135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SXIM_RS22140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SXIM_RS22150	COG0455	bacterial-type flagellum organization
SXIM_RS22170	COG3266	domain, Protein
SXIM_RS22175	COG1404	Belongs to the peptidase S8 family
SXIM_RS22240	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SXIM_RS22245	COG1185	polyribonucleotide nucleotidyltransferase activity
SXIM_RS22250	COG0612	Peptidase, M16
SXIM_RS22255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SXIM_RS22270	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SXIM_RS22275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SXIM_RS22280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SXIM_RS22305	COG2770	Histidine kinase
SXIM_RS22305	COG2208	phosphoserine phosphatase activity
SXIM_RS22310	COG2205	protein histidine kinase activity
SXIM_RS22310	COG4999	Histidine kinase
SXIM_RS22310	COG3850	Histidine kinase
SXIM_RS22310	COG3437	response regulator, receiver
SXIM_RS22320	COG1674	ftsk spoiiie
SXIM_RS22330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SXIM_RS22340	COG1546	Belongs to the CinA family
SXIM_RS22340	COG1058	Belongs to the CinA family
SXIM_RS22345	COG1396	sequence-specific DNA binding
SXIM_RS22360	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SXIM_RS22365	COG2137	regulation of response to DNA damage stimulus
SXIM_RS22370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SXIM_RS22375	COG0765	amino acid transport
SXIM_RS22380	COG0765	amino acid transport
SXIM_RS22385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SXIM_RS22390	COG1126	abc transporter atp-binding protein
SXIM_RS22395	COG0745	RESPONSE REGULATOR receiver
SXIM_RS22415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SXIM_RS22435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SXIM_RS22445	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SXIM_RS22450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SXIM_RS22455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SXIM_RS22465	COG1609	Transcriptional regulator
SXIM_RS22470	COG1233	COG1233 Phytoene dehydrogenase and related
SXIM_RS22485	COG0395	ABC-type sugar transport system, permease component
SXIM_RS22495	COG2770	Histidine kinase
SXIM_RS22495	COG2208	phosphoserine phosphatase activity
SXIM_RS22505	COG0488	(ABC) transporter
SXIM_RS22510	COG0488	(ABC) transporter
SXIM_RS22520	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SXIM_RS22535	COG1129	ABC transporter
SXIM_RS22550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SXIM_RS22555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SXIM_RS22560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SXIM_RS22580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SXIM_RS22585	COG0514	ATP-dependent DNA helicase (RecQ)
SXIM_RS22600	COG1802	Transcriptional regulator
SXIM_RS22605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SXIM_RS22620	COG0187	DNA topoisomerase II activity
SXIM_RS22630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SXIM_RS22635	COG0612	Peptidase, M16
SXIM_RS22645	COG1802	Transcriptional regulator
SXIM_RS22650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SXIM_RS22670	COG1435	thymidine kinase activity
SXIM_RS22695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SXIM_RS22700	COG0483	inositol monophosphate 1-phosphatase activity
SXIM_RS22705	COG0745	RESPONSE REGULATOR receiver
SXIM_RS22710	COG2205	protein histidine kinase activity
SXIM_RS22725	COG0756	dUTP diphosphatase activity
SXIM_RS22765	COG0569	domain protein
SXIM_RS22770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SXIM_RS22775	COG1278	Cold shock
SXIM_RS22780	COG0513	Belongs to the DEAD box helicase family
SXIM_RS22810	COG2040	homocysteine
SXIM_RS22815	COG2267	carboxylic ester hydrolase activity
SXIM_RS22820	COG4122	O-methyltransferase activity
SXIM_RS22835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SXIM_RS22860	COG1309	transcriptional regulator
SXIM_RS22865	COG2409	Drug exporters of the RND superfamily
SXIM_RS22915	COG1518	maintenance of DNA repeat elements
SXIM_RS22920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SXIM_RS22935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SXIM_RS22940	COG1653	transport
SXIM_RS22945	COG1175	transmembrane transport
SXIM_RS22950	COG0395	ABC-type sugar transport system, permease component
SXIM_RS22955	COG1940	carbohydrate kinase activity
SXIM_RS22970	COG4214	carbohydrate transport
SXIM_RS22975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SXIM_RS22995	COG0183	Belongs to the thiolase family
SXIM_RS23015	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SXIM_RS23020	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SXIM_RS23025	COG3253	May function as heme-dependent peroxidase
SXIM_RS23030	COG2326	polyphosphate kinase activity
SXIM_RS23050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SXIM_RS23055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SXIM_RS23065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SXIM_RS23130	COG0431	NADPH-dependent FMN reductase
SXIM_RS23135	COG0745	RESPONSE REGULATOR receiver
SXIM_RS23145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SXIM_RS23150	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SXIM_RS23155	COG4521	taurine ABC transporter
SXIM_RS23170	COG0529	Catalyzes the synthesis of activated sulfate
SXIM_RS23175	COG0175	sulfate reduction
SXIM_RS23185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SXIM_RS23195	COG1960	acyl-CoA dehydrogenase activity
SXIM_RS23210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SXIM_RS23215	COG3467	pyridoxamine 5'-phosphate
SXIM_RS23245	COG1802	Transcriptional regulator
SXIM_RS23260	COG3835	regulator
SXIM_RS23275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SXIM_RS23305	COG2351	hydroxyisourate hydrolase activity
SXIM_RS23325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SXIM_RS23340	COG1414	Transcriptional regulator
SXIM_RS23345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SXIM_RS23350	COG4266	Belongs to the allantoicase family
SXIM_RS23385	COG1940	carbohydrate kinase activity
SXIM_RS23395	COG1122	ATPase activity
SXIM_RS23415	COG1929	Belongs to the glycerate kinase type-1 family
SXIM_RS23420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SXIM_RS23430	COG0483	inositol monophosphate 1-phosphatase activity
SXIM_RS23455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SXIM_RS23460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SXIM_RS23520	COG1120	ATPase activity
SXIM_RS23525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SXIM_RS23535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SXIM_RS23555	COG3938	Belongs to the proline racemase family
SXIM_RS23560	COG1802	Transcriptional regulator
SXIM_RS23565	COG0747	negative chemotaxis
SXIM_RS23570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SXIM_RS23575	COG0601	transmembrane transport
SXIM_RS23585	COG4172	Belongs to the ABC transporter superfamily
SXIM_RS23595	COG0006	proline dipeptidase activity
SXIM_RS23625	COG1131	(ABC) transporter
SXIM_RS23660	COG1024	Enoyl-CoA hydratase
SXIM_RS23665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SXIM_RS23690	COG0708	Exodeoxyribonuclease III
SXIM_RS23705	COG0688	phosphatidylethanolamine metabolic process
SXIM_RS23710	COG2301	Belongs to the HpcH HpaI aldolase family
SXIM_RS23730	COG1011	Hydrolase
SXIM_RS23740	COG0583	DNA-binding transcription factor activity
SXIM_RS23780	COG1609	Transcriptional regulator
SXIM_RS23790	COG1175	transmembrane transport
SXIM_RS23830	COG2362	D-Aminopeptidase
SXIM_RS23835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SXIM_RS23855	COG1619	proteins homologs of microcin C7 resistance protein MccF
SXIM_RS23875	COG2318	DinB family
SXIM_RS23910	COG0395	ABC-type sugar transport system, permease component
SXIM_RS23915	COG1063	alcohol dehydrogenase
SXIM_RS23935	COG3903	Transcriptional regulator
SXIM_RS23935	COG3629	intracellular signal transduction
SXIM_RS23940	COG2226	methyltransferase
SXIM_RS23955	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SXIM_RS23980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SXIM_RS23990	COG2154	pterin-4-alpha-carbinolamine dehydratase
SXIM_RS24015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SXIM_RS24020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SXIM_RS24045	COG0656	L-ascorbic acid biosynthetic process
SXIM_RS24055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SXIM_RS24130	COG2207	Transcriptional regulator
SXIM_RS24130	COG3708	Transcriptional regulator
SXIM_RS24140	COG0587	DNA-directed DNA polymerase activity
SXIM_RS24150	COG0277	FAD linked oxidase domain protein
SXIM_RS24185	COG1162	GTPase activity
SXIM_RS24190	COG1609	Transcriptional regulator
SXIM_RS24195	COG4209	transmembrane transport
SXIM_RS24200	COG0395	ABC-type sugar transport system, permease component
SXIM_RS24230	COG2226	methyltransferase
SXIM_RS24265	COG1215	transferase activity, transferring glycosyl groups
SXIM_RS24285	COG3845	ABC transporter
SXIM_RS24315	COG2409	Drug exporters of the RND superfamily
SXIM_RS24320	COG2356	endonuclease I
SXIM_RS24325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SXIM_RS24340	COG1132	(ABC) transporter
SXIM_RS24350	COG1595	DNA-templated transcription, initiation
SXIM_RS24360	COG4214	carbohydrate transport
SXIM_RS24370	COG4213	ABC transporter substrate-binding protein
SXIM_RS24375	COG0406	alpha-ribazole phosphatase activity
SXIM_RS24380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SXIM_RS24385	COG1070	Carbohydrate kinase
SXIM_RS24390	COG1070	Carbohydrate kinase
SXIM_RS24400	COG3509	depolymerase
SXIM_RS24430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SXIM_RS24440	COG0798	PFAM Bile acid sodium symporter
SXIM_RS24445	COG0640	Transcriptional regulator
SXIM_RS24450	COG0493	'glutamate synthase
SXIM_RS24460	COG4948	Mandelate Racemase Muconate Lactonizing
SXIM_RS24465	COG0395	ABC-type sugar transport system, permease component
SXIM_RS24490	COG3693	PFAM glycoside hydrolase, family 10
SXIM_RS24490	COG3509	depolymerase
SXIM_RS24500	COG0494	nUDIX hydrolase
SXIM_RS24510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SXIM_RS24510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SXIM_RS24525	COG0148	phosphopyruvate hydratase activity
SXIM_RS24545	COG0488	(ABC) transporter
SXIM_RS24620	COG2267	carboxylic ester hydrolase activity
SXIM_RS24625	COG0604	alcohol dehydrogenase
SXIM_RS24640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SXIM_RS24655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SXIM_RS24665	COG1396	sequence-specific DNA binding
SXIM_RS24665	COG3800	Transcriptional regulator
SXIM_RS24670	COG1090	epimerase
SXIM_RS24675	COG1404	Belongs to the peptidase S8 family
SXIM_RS24685	COG1595	DNA-templated transcription, initiation
SXIM_RS24690	COG1609	Transcriptional regulator
SXIM_RS24695	COG4149	molybdate abc transporter
SXIM_RS24700	COG1177	transmembrane transport
SXIM_RS24705	COG3842	ATPase activity
SXIM_RS24730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SXIM_RS24745	COG2755	lipolytic protein G-D-S-L family
SXIM_RS24820	COG2124	cytochrome p450
SXIM_RS24825	COG1024	Enoyl-CoA hydratase
SXIM_RS24830	COG3360	Dodecin
SXIM_RS24835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SXIM_RS24840	COG1515	deoxyribonuclease V activity
SXIM_RS24845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SXIM_RS24875	COG0702	epimerase
SXIM_RS24880	COG1733	regulation of RNA biosynthetic process
SXIM_RS24885	COG1309	transcriptional regulator
SXIM_RS24895	COG2409	Drug exporters of the RND superfamily
SXIM_RS24900	COG2183	response to ionizing radiation
SXIM_RS24910	COG0488	(ABC) transporter
SXIM_RS24915	COG1132	(ABC) transporter
SXIM_RS24925	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SXIM_RS24950	COG0371	Dehydrogenase
SXIM_RS24970	COG1134	teichoic acid transport
SXIM_RS24975	COG1562	ergosterol biosynthetic process
SXIM_RS24985	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SXIM_RS25020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SXIM_RS25025	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SXIM_RS25040	COG1652	LysM domain
SXIM_RS25045	COG1690	Belongs to the RtcB family
SXIM_RS25055	COG1940	carbohydrate kinase activity
SXIM_RS25055	COG1846	Transcriptional regulator
SXIM_RS25095	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS25120	COG1501	Belongs to the glycosyl hydrolase 31 family
SXIM_RS25130	COG0395	ABC-type sugar transport system, permease component
SXIM_RS25135	COG1175	transmembrane transport
SXIM_RS25145	COG1609	Transcriptional regulator
SXIM_RS25150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SXIM_RS25155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SXIM_RS25160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SXIM_RS25165	COG0156	8-amino-7-oxononanoate synthase activity
SXIM_RS25175	COG1793	dna ligase
SXIM_RS25185	COG2072	flavoprotein involved in K transport
SXIM_RS25220	COG0747	negative chemotaxis
SXIM_RS25225	COG0601	transmembrane transport
SXIM_RS25230	COG0444	Belongs to the ABC transporter superfamily
SXIM_RS25235	COG4608	Belongs to the ABC transporter superfamily
SXIM_RS25260	COG0477	Major facilitator Superfamily
SXIM_RS25270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SXIM_RS25300	COG1653	transport
SXIM_RS25305	COG1175	transmembrane transport
SXIM_RS25310	COG0395	ABC-type sugar transport system, permease component
SXIM_RS25315	COG3285	dna ligase
SXIM_RS25315	COG1793	dna ligase
SXIM_RS25325	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SXIM_RS25360	COG0702	epimerase
SXIM_RS25365	COG1120	ATPase activity
SXIM_RS25370	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SXIM_RS25385	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SXIM_RS25410	COG3573	Dehydrogenase
SXIM_RS25450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SXIM_RS25455	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SXIM_RS25485	COG2192	nodulation
SXIM_RS25495	COG3903	Transcriptional regulator
SXIM_RS25495	COG3629	intracellular signal transduction
SXIM_RS25515	COG2971	BadF BadG BcrA BcrD
SXIM_RS25520	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SXIM_RS25525	COG1902	pentaerythritol trinitrate reductase activity
SXIM_RS25570	COG0584	glycerophosphoryl diester phosphodiesterase
SXIM_RS25590	COG0204	Acyl-transferase
SXIM_RS25605	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SXIM_RS25615	COG1940	carbohydrate kinase activity
SXIM_RS25620	COG1660	Displays ATPase and GTPase activities
SXIM_RS25645	COG0738	Major facilitator superfamily
SXIM_RS25650	COG1940	carbohydrate kinase activity
SXIM_RS25665	COG3442	glutamine amidotransferase
SXIM_RS25730	COG1414	Transcriptional regulator
SXIM_RS25735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SXIM_RS25740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SXIM_RS25745	COG1794	racemase activity, acting on amino acids and derivatives
SXIM_RS25780	COG1120	ATPase activity
SXIM_RS25810	COG2186	Transcriptional regulator
SXIM_RS25825	COG3842	ATPase activity
SXIM_RS25830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SXIM_RS25845	COG2226	methyltransferase
SXIM_RS25865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SXIM_RS25870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SXIM_RS25960	COG0673	inositol 2-dehydrogenase activity
SXIM_RS25980	COG2409	Drug exporters of the RND superfamily
SXIM_RS26005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SXIM_RS26010	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SXIM_RS26020	COG2610	gluconate transmembrane transporter activity
SXIM_RS26035	COG1595	DNA-templated transcription, initiation
SXIM_RS26055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SXIM_RS26085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SXIM_RS26090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SXIM_RS26105	COG2205	protein histidine kinase activity
SXIM_RS26110	COG0745	RESPONSE REGULATOR receiver
SXIM_RS26115	COG1017	nitric oxide dioxygenase activity
SXIM_RS26115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SXIM_RS26135	COG0640	Transcriptional regulator
SXIM_RS26160	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SXIM_RS26165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SXIM_RS26210	COG1832	CoA-binding protein
SXIM_RS26215	COG1739	Uncharacterized protein family UPF0029
SXIM_RS26220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SXIM_RS26225	COG0431	NADPH-dependent FMN reductase
SXIM_RS26230	COG4677	pectinesterase activity
SXIM_RS26235	COG0420	3'-5' exonuclease activity
SXIM_RS26240	COG0419	ATPase involved in DNA repair
SXIM_RS26245	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS26260	COG1595	DNA-templated transcription, initiation
SXIM_RS26265	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS26270	COG2188	Transcriptional regulator
SXIM_RS26275	COG1940	carbohydrate kinase activity
SXIM_RS26280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SXIM_RS26340	COG1595	DNA-templated transcription, initiation
SXIM_RS26365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SXIM_RS26370	COG1834	amidinotransferase
SXIM_RS26380	COG4762	Protein conserved in bacteria
SXIM_RS26385	COG1129	ABC transporter
SXIM_RS26390	COG1172	Belongs to the binding-protein-dependent transport system permease family
SXIM_RS26400	COG1879	ABC-type sugar transport system periplasmic component
SXIM_RS26415	COG0246	Mannitol dehydrogenase
SXIM_RS26420	COG0477	Major facilitator Superfamily
SXIM_RS26425	COG1063	alcohol dehydrogenase
SXIM_RS26435	COG0800	Aldolase
SXIM_RS26495	COG0137	argininosuccinate synthase activity
SXIM_RS26500	COG3340	Belongs to the peptidase S51 family
SXIM_RS26545	COG4948	Mandelate Racemase Muconate Lactonizing
SXIM_RS26565	COG2186	Transcriptional regulator
SXIM_RS26580	COG0346	lactoylglutathione lyase activity
SXIM_RS26585	COG0640	Transcriptional regulator
SXIM_RS26590	COG0656	L-ascorbic acid biosynthetic process
SXIM_RS26635	COG3250	beta-galactosidase activity
SXIM_RS26640	COG0395	ABC-type sugar transport system, permease component
SXIM_RS26645	COG1175	transmembrane transport
SXIM_RS26660	COG1609	Transcriptional regulator
SXIM_RS26665	COG1175	transmembrane transport
SXIM_RS26670	COG0395	ABC-type sugar transport system, permease component
SXIM_RS26750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SXIM_RS26760	COG2212	antiporter activity
SXIM_RS26770	COG0651	ATP synthesis coupled electron transport
SXIM_RS26775	COG1006	Multisubunit Na H antiporter MnhC subunit
SXIM_RS26780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SXIM_RS26780	COG2111	Na H antiporter
SXIM_RS26785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SXIM_RS26790	COG0789	Transcriptional regulator
SXIM_RS26795	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS26800	COG1309	transcriptional regulator
SXIM_RS26815	COG2217	Heavy metal translocating P-type atpase
SXIM_RS26840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SXIM_RS26840	COG0574	Belongs to the PEP-utilizing enzyme family
SXIM_RS26845	COG1042	CoA-binding domain protein
SXIM_RS26845	COG0045	succinate-CoA ligase (ADP-forming) activity
SXIM_RS26845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SXIM_RS26855	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SXIM_RS26860	COG0298	carbon dioxide binding
SXIM_RS26875	COG0543	2 iron, 2 sulfur cluster binding
SXIM_RS26890	COG0409	Hydrogenase expression formation protein
SXIM_RS26895	COG0309	Hydrogenase expression formation protein (HypE)
SXIM_RS26905	COG3226	Transcriptional regulator
SXIM_RS26910	COG0738	Major facilitator superfamily
SXIM_RS26920	COG1733	regulation of RNA biosynthetic process
SXIM_RS26955	COG0583	DNA-binding transcription factor activity
SXIM_RS26965	COG1012	belongs to the aldehyde dehydrogenase family
SXIM_RS26970	COG0402	S-adenosylhomocysteine deaminase activity
SXIM_RS26975	COG0604	alcohol dehydrogenase
SXIM_RS26975	COG1028	Short-chain dehydrogenase reductase Sdr
SXIM_RS26975	COG3321	synthase
SXIM_RS26980	COG1024	Enoyl-CoA hydratase
SXIM_RS26985	COG1733	regulation of RNA biosynthetic process
SXIM_RS27005	COG0745	RESPONSE REGULATOR receiver
SXIM_RS27010	COG2205	protein histidine kinase activity
SXIM_RS27020	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SXIM_RS27025	COG1181	Belongs to the D-alanine--D-alanine ligase family