locus-tag	class	description
SROS_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SROS_RS00010	COG0592	DNA-directed DNA polymerase activity
SROS_RS00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SROS_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SROS_RS00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SROS_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SROS_RS00085	COG1937	Protein conserved in bacteria
SROS_RS00090	COG2608	mercury ion transmembrane transporter activity
SROS_RS00135	COG0714	Associated with various cellular activities
SROS_RS00140	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SROS_RS00155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SROS_RS00295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SROS_RS00310	COG1051	belongs to the nudix hydrolase family
SROS_RS00320	COG2172	sigma factor antagonist activity
SROS_RS00325	COG1366	Belongs to the anti-sigma-factor antagonist family
SROS_RS00345	COG2311	Membrane
SROS_RS00350	COG4585	Histidine kinase
SROS_RS00355	COG2197	response regulator
SROS_RS00380	COG0582	viral genome integration into host DNA
SROS_RS00385	COG0596	Alpha beta hydrolase
SROS_RS00420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS00445	COG2197	response regulator
SROS_RS00450	COG4585	Histidine kinase
SROS_RS00475	COG1595	DNA-templated transcription, initiation
SROS_RS00500	COG2205	protein histidine kinase activity
SROS_RS00505	COG0745	RESPONSE REGULATOR receiver
SROS_RS00545	COG0515	serine threonine protein kinase
SROS_RS00550	COG0515	serine threonine protein kinase
SROS_RS00555	COG0768	penicillin binding
SROS_RS00570	COG1716	ATPase activity
SROS_RS00595	COG1316	TRANSCRIPTIONal
SROS_RS00610	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SROS_RS00615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SROS_RS00625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SROS_RS00630	COG5002	protein histidine kinase activity
SROS_RS00640	COG0706	membrane insertase activity
SROS_RS00650	COG0745	RESPONSE REGULATOR receiver
SROS_RS00655	COG5002	protein histidine kinase activity
SROS_RS00670	COG1215	transferase activity, transferring glycosyl groups
SROS_RS00680	COG5650	phosphatidylinositol metabolic process
SROS_RS00695	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SROS_RS00700	COG1278	Cold shock
SROS_RS00705	COG0561	phosphatase activity
SROS_RS00745	COG1674	ftsk spoiiie
SROS_RS00755	COG2188	Transcriptional regulator
SROS_RS00770	COG1609	Transcriptional regulator
SROS_RS00860	COG1522	sequence-specific DNA binding
SROS_RS00890	COG0701	Predicted permease
SROS_RS00920	COG1595	DNA-templated transcription, initiation
SROS_RS00925	COG1846	Transcriptional regulator
SROS_RS00955	COG2197	response regulator
SROS_RS01005	COG1404	Belongs to the peptidase S8 family
SROS_RS01075	COG1595	DNA-templated transcription, initiation
SROS_RS01090	COG2197	response regulator
SROS_RS01095	COG3850	Histidine kinase
SROS_RS01140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SROS_RS01160	COG2272	Belongs to the type-B carboxylesterase lipase family
SROS_RS01175	COG2814	Major facilitator Superfamily
SROS_RS01180	COG3293	Transposase
SROS_RS01215	COG2205	protein histidine kinase activity
SROS_RS01220	COG0745	RESPONSE REGULATOR receiver
SROS_RS01255	COG1136	(ABC) transporter
SROS_RS01255	COG0577	efflux transmembrane transporter activity
SROS_RS01275	COG1131	(ABC) transporter
SROS_RS01285	COG4585	Histidine kinase
SROS_RS01290	COG2197	response regulator
SROS_RS01300	COG2197	response regulator
SROS_RS01350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SROS_RS01355	COG1733	regulation of RNA biosynthetic process
SROS_RS01360	COG1309	transcriptional regulator
SROS_RS01365	COG1250	3-hydroxyacyl-CoA dehydrogenase
SROS_RS01365	COG1024	Enoyl-CoA hydratase
SROS_RS01375	COG0395	ABC-type sugar transport system, permease component
SROS_RS01380	COG1175	transmembrane transport
SROS_RS01385	COG1653	transport
SROS_RS01395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SROS_RS01420	COG2205	protein histidine kinase activity
SROS_RS01425	COG0745	RESPONSE REGULATOR receiver
SROS_RS01440	COG1136	(ABC) transporter
SROS_RS01440	COG0577	efflux transmembrane transporter activity
SROS_RS01445	COG0577	efflux transmembrane transporter activity
SROS_RS01475	COG2319	Wd-40 repeat
SROS_RS01505	COG2272	Belongs to the type-B carboxylesterase lipase family
SROS_RS01520	COG1733	regulation of RNA biosynthetic process
SROS_RS01525	COG4585	Histidine kinase
SROS_RS01535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SROS_RS01540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SROS_RS01545	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SROS_RS01550	COG0121	glutamine amidotransferase
SROS_RS01555	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SROS_RS01560	COG3572	ergothioneine biosynthetic process
SROS_RS01570	COG1595	DNA-templated transcription, initiation
SROS_RS01580	COG0252	asparaginase activity
SROS_RS01585	COG1764	response to oxidative stress
SROS_RS01615	COG0702	epimerase
SROS_RS01620	COG1295	ribonuclease BN
SROS_RS01625	COG0697	spore germination
SROS_RS01635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SROS_RS01655	COG1940	carbohydrate kinase activity
SROS_RS01665	COG1070	Carbohydrate kinase
SROS_RS01700	COG2018	Roadblock/LC7 domain
SROS_RS01715	COG3594	Acyltransferase
SROS_RS01730	COG2268	Band 7 protein
SROS_RS01790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SROS_RS01795	COG0697	spore germination
SROS_RS01805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SROS_RS01815	COG0151	Belongs to the GarS family
SROS_RS01820	COG0598	Magnesium transport protein CorA
SROS_RS01825	COG0584	glycerophosphoryl diester phosphodiesterase
SROS_RS01830	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SROS_RS01845	COG0586	Pfam SNARE associated Golgi protein
SROS_RS01855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SROS_RS01865	COG1432	Conserved Protein
SROS_RS01870	COG1132	(ABC) transporter
SROS_RS01885	COG0784	Response regulator, receiver
SROS_RS01885	COG2205	protein histidine kinase activity
SROS_RS01890	COG2208	phosphoserine phosphatase activity
SROS_RS01890	COG2770	Histidine kinase
SROS_RS01910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SROS_RS01930	COG3135	benzoate transporter
SROS_RS01940	COG2072	flavoprotein involved in K transport
SROS_RS01960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS01985	COG1132	(ABC) transporter
SROS_RS01990	COG1070	Carbohydrate kinase
SROS_RS02010	COG3347	Dehydrogenase
SROS_RS02010	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS02025	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SROS_RS02030	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SROS_RS02035	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SROS_RS02115	COG0596	Alpha beta hydrolase
SROS_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS02155	COG1408	metallophosphoesterase
SROS_RS02165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SROS_RS02175	COG0003	Pfam Anion-transporting ATPase
SROS_RS02195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SROS_RS02210	COG0494	nUDIX hydrolase
SROS_RS02230	COG0596	Alpha beta hydrolase
SROS_RS02240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SROS_RS02245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SROS_RS02315	COG1205	dead DEAH box helicase
SROS_RS02315	COG1111	helicase
SROS_RS02320	COG1366	Belongs to the anti-sigma-factor antagonist family
SROS_RS02325	COG2172	sigma factor antagonist activity
SROS_RS02330	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SROS_RS02345	COG3830	Belongs to the UPF0237 family
SROS_RS02345	COG0560	Phosphoserine phosphatase
SROS_RS02360	COG2197	response regulator
SROS_RS02375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SROS_RS02380	COG4585	Histidine kinase
SROS_RS02385	COG2197	response regulator
SROS_RS02395	COG1119	ATPase activity
SROS_RS02420	COG0243	molybdopterin cofactor binding
SROS_RS02430	COG0753	catalase activity
SROS_RS02450	COG1309	transcriptional regulator
SROS_RS02470	COG0542	response to heat
SROS_RS02475	COG0789	Transcriptional regulator
SROS_RS02480	COG0484	heat shock protein binding
SROS_RS02485	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SROS_RS02490	COG0443	Heat shock 70 kDa protein
SROS_RS02515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SROS_RS02525	COG0123	including yeast histone deacetylase and acetoin utilization protein
SROS_RS02555	COG0560	Phosphoserine phosphatase
SROS_RS02580	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SROS_RS02585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SROS_RS02590	COG0181	hydroxymethylbilane synthase activity
SROS_RS02600	COG0113	porphobilinogen synthase activity
SROS_RS02610	COG2197	response regulator
SROS_RS02625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SROS_RS02640	COG0154	amidase activity
SROS_RS02645	COG0179	Fumarylacetoacetate (FAA) hydrolase
SROS_RS02700	COG0406	alpha-ribazole phosphatase activity
SROS_RS02705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SROS_RS02710	COG0785	Cytochrome C biogenesis protein
SROS_RS02720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SROS_RS02750	COG2226	methyltransferase
SROS_RS02765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SROS_RS02770	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SROS_RS02775	COG0649	NAD binding
SROS_RS02785	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SROS_RS02790	COG1034	ATP synthesis coupled electron transport
SROS_RS02795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SROS_RS02800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SROS_RS02830	COG0142	geranyltranstransferase activity
SROS_RS02840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SROS_RS02845	COG3177	Filamentation induced by cAMP protein fic
SROS_RS02860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SROS_RS02865	COG3321	synthase
SROS_RS02865	COG0604	alcohol dehydrogenase
SROS_RS02875	COG2197	response regulator
SROS_RS02880	COG4585	Histidine kinase
SROS_RS02900	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS02920	COG0596	Alpha beta hydrolase
SROS_RS02925	COG2770	Histidine kinase
SROS_RS02925	COG2208	phosphoserine phosphatase activity
SROS_RS02940	COG0456	acetyltransferase
SROS_RS02965	COG0697	spore germination
SROS_RS02980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SROS_RS03010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SROS_RS03025	COG4310	Domain of unknown function (DUF2172)
SROS_RS03040	COG1215	transferase activity, transferring glycosyl groups
SROS_RS03050	COG2755	lipolytic protein G-D-S-L family
SROS_RS03050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SROS_RS03110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SROS_RS03130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SROS_RS03135	COG1013	pyruvate-flavodoxin oxidoreductase activity
SROS_RS03140	COG0674	pyruvate-flavodoxin oxidoreductase activity
SROS_RS03140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SROS_RS03145	COG0726	polysaccharide deacetylase
SROS_RS03150	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SROS_RS03155	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SROS_RS03160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SROS_RS03165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SROS_RS03180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SROS_RS03190	COG0713	ATP synthesis coupled electron transport
SROS_RS03195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SROS_RS03205	COG1007	ATP synthesis coupled electron transport
SROS_RS03210	COG0501	Belongs to the peptidase M48B family
SROS_RS03255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SROS_RS03285	COG1666	GTP binding
SROS_RS03335	COG1609	Transcriptional regulator
SROS_RS03420	COG0789	Transcriptional regulator
SROS_RS03425	COG1742	UPF0060 membrane protein
SROS_RS03440	COG1609	Transcriptional regulator
SROS_RS03505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SROS_RS03550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SROS_RS03555	COG2030	dehydratase
SROS_RS03570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SROS_RS03575	COG2119	membrane
SROS_RS03600	COG4166	transmembrane transport
SROS_RS03615	COG0601	transmembrane transport
SROS_RS03675	COG1595	DNA-templated transcription, initiation
SROS_RS03710	COG1396	sequence-specific DNA binding
SROS_RS03715	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SROS_RS03715	COG1672	PFAM Archaeal ATPase
SROS_RS03730	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SROS_RS03735	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS03740	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS03745	COG0154	amidase activity
SROS_RS03765	COG1643	Atp-dependent helicase
SROS_RS03780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SROS_RS03785	COG1968	undecaprenyl-diphosphatase activity
SROS_RS03790	COG1595	DNA-templated transcription, initiation
SROS_RS03815	COG0321	lipoyl(octanoyl) transferase activity
SROS_RS03920	COG0243	molybdopterin cofactor binding
SROS_RS03930	COG2132	Multicopper oxidase
SROS_RS03950	COG2318	DinB family
SROS_RS03960	COG1131	(ABC) transporter
SROS_RS03970	COG4585	Histidine kinase
SROS_RS03975	COG2197	response regulator
SROS_RS03990	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS03995	COG0477	Major facilitator Superfamily
SROS_RS04025	COG0793	Belongs to the peptidase S41A family
SROS_RS04030	COG0745	RESPONSE REGULATOR receiver
SROS_RS04035	COG2205	protein histidine kinase activity
SROS_RS04040	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SROS_RS04060	COG0583	DNA-binding transcription factor activity
SROS_RS04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS04085	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS04090	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SROS_RS04095	COG1132	(ABC) transporter
SROS_RS04140	COG0667	Aldo Keto reductase
SROS_RS04160	COG1404	Belongs to the peptidase S8 family
SROS_RS04235	COG0717	Belongs to the dCTP deaminase family
SROS_RS04250	COG0456	acetyltransferase
SROS_RS04250	COG0454	-acetyltransferase
SROS_RS04255	COG0737	Belongs to the 5'-nucleotidase family
SROS_RS04260	COG0745	RESPONSE REGULATOR receiver
SROS_RS04350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SROS_RS04355	COG3442	glutamine amidotransferase
SROS_RS04365	COG4044	May play a role in the intracellular transport of hydrophobic ligands
SROS_RS04375	COG0735	belongs to the Fur family
SROS_RS04390	COG1490	D-aminoacyl-tRNA deacylase activity
SROS_RS04420	COG4585	Histidine kinase
SROS_RS04425	COG2197	response regulator
SROS_RS04460	COG5297	Belongs to the glycosyl hydrolase family 6
SROS_RS04460	COG4733	cellulase activity
SROS_RS04465	COG1609	Transcriptional regulator
SROS_RS04470	COG0366	Alpha amylase catalytic
SROS_RS04485	COG1175	transmembrane transport
SROS_RS04490	COG3833	ABC-type maltose transport systems, permease component
SROS_RS04505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SROS_RS04560	COG0438	transferase activity, transferring glycosyl groups
SROS_RS04570	COG0588	phosphoglycerate mutase activity
SROS_RS04580	COG5002	protein histidine kinase activity
SROS_RS04595	COG1329	Transcriptional regulator
SROS_RS04600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SROS_RS04605	COG2261	transglycosylase associated protein
SROS_RS04610	COG2261	transglycosylase associated protein
SROS_RS04630	COG0215	cysteine-tRNA ligase activity
SROS_RS04635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SROS_RS04675	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SROS_RS04695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SROS_RS04745	COG0310	cobalt ion transport
SROS_RS04755	COG1122	ATPase activity
SROS_RS04760	COG1366	Belongs to the anti-sigma-factor antagonist family
SROS_RS04790	COG0477	Major facilitator Superfamily
SROS_RS04800	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SROS_RS04810	COG0259	pyridoxamine-phosphate oxidase activity
SROS_RS04815	COG0477	Major facilitator Superfamily
SROS_RS04850	COG1960	acyl-CoA dehydrogenase activity
SROS_RS04920	COG0596	Alpha beta hydrolase
SROS_RS04945	COG3903	Transcriptional regulator
SROS_RS04945	COG3629	intracellular signal transduction
SROS_RS04960	COG0657	acetylesterase activity
SROS_RS04985	COG0584	glycerophosphoryl diester phosphodiesterase
SROS_RS05025	COG0183	Belongs to the thiolase family
SROS_RS05060	COG1595	DNA-templated transcription, initiation
SROS_RS05075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SROS_RS05085	COG0436	Aminotransferase
SROS_RS05105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SROS_RS05110	COG0081	regulation of translation
SROS_RS05120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SROS_RS05125	COG0222	ribosome binding
SROS_RS05155	COG0085	RNA polymerase activity
SROS_RS05160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SROS_RS05165	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SROS_RS05170	COG0049	tRNA binding
SROS_RS05175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SROS_RS05185	COG0051	transcription antitermination factor activity, RNA binding
SROS_RS05190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SROS_RS05195	COG0088	Forms part of the polypeptide exit tunnel
SROS_RS05200	COG0089	rRNA binding
SROS_RS05205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SROS_RS05210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SROS_RS05215	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SROS_RS05220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SROS_RS05225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SROS_RS05230	COG0255	Belongs to the universal ribosomal protein uL29 family
SROS_RS05235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SROS_RS05240	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SROS_RS05245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SROS_RS05250	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SROS_RS05255	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SROS_RS05260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SROS_RS05265	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SROS_RS05270	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SROS_RS05275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SROS_RS05280	COG1841	ribosomal large subunit assembly
SROS_RS05285	COG0200	Binds to the 23S rRNA
SROS_RS05295	COG0563	adenylate kinase activity
SROS_RS05325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SROS_RS05330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SROS_RS05335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SROS_RS05340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SROS_RS05345	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SROS_RS05350	COG0202	RNA polymerase activity
SROS_RS05355	COG0203	ribosomal protein L17
SROS_RS05360	COG0101	tRNA pseudouridine synthase activity
SROS_RS05380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SROS_RS05385	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SROS_RS05390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SROS_RS05430	COG1131	(ABC) transporter
SROS_RS05440	COG1072	(Pantothenic acid kinase))
SROS_RS05445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SROS_RS05450	COG0736	holo-[acyl-carrier-protein] synthase activity
SROS_RS05460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SROS_RS05470	COG0802	atpase or kinase
SROS_RS05490	COG1214	PFAM Peptidase M22, glycoprotease
SROS_RS05490	COG0456	acetyltransferase
SROS_RS05495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SROS_RS05505	COG1846	Transcriptional regulator
SROS_RS05525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SROS_RS05530	COG0459	protein refolding
SROS_RS05535	COG1595	DNA-templated transcription, initiation
SROS_RS05560	COG0516	GMP reductase activity
SROS_RS05580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SROS_RS05585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SROS_RS05590	COG1349	DNA-binding transcription factor activity
SROS_RS05615	COG1595	DNA-templated transcription, initiation
SROS_RS05620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SROS_RS05630	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS05640	COG0076	glutamate decarboxylase activity
SROS_RS05650	COG1733	regulation of RNA biosynthetic process
SROS_RS05655	COG0702	epimerase
SROS_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS05670	COG0519	Catalyzes the synthesis of GMP from XMP
SROS_RS05670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SROS_RS05690	COG0726	polysaccharide deacetylase
SROS_RS05745	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
SROS_RS05750	COG1086	Polysaccharide biosynthesis protein
SROS_RS05755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SROS_RS05770	COG1216	Glycosyl transferase, family 2
SROS_RS05775	COG2089	acid synthase
SROS_RS05780	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SROS_RS05785	COG1183	phosphatidylcholine synthase activity
SROS_RS05790	COG0457	Tetratricopeptide repeat
SROS_RS05795	COG0457	Tetratricopeptide repeat
SROS_RS05800	COG0438	transferase activity, transferring glycosyl groups
SROS_RS05805	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SROS_RS05810	COG3629	intracellular signal transduction
SROS_RS05820	COG0702	epimerase
SROS_RS05825	COG0596	Alpha beta hydrolase
SROS_RS05900	COG2197	response regulator
SROS_RS05930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SROS_RS05955	COG3250	beta-galactosidase activity
SROS_RS05965	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SROS_RS05970	COG0045	succinate-CoA ligase (ADP-forming) activity
SROS_RS05995	COG0138	bifunctional purine biosynthesis protein purh
SROS_RS06000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SROS_RS06010	COG0372	Belongs to the citrate synthase family
SROS_RS06020	COG0538	isocitrate dehydrogenase activity
SROS_RS06040	COG0477	Major facilitator Superfamily
SROS_RS06045	COG0039	L-malate dehydrogenase activity
SROS_RS06055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SROS_RS06060	COG1253	flavin adenine dinucleotide binding
SROS_RS06065	COG0180	Tryptophanyl-tRNA synthetase
SROS_RS06075	COG1686	Belongs to the peptidase S11 family
SROS_RS06090	COG1473	amidohydrolase
SROS_RS06090	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SROS_RS06095	COG1744	ABC transporter substrate-binding protein PnrA-like
SROS_RS06100	COG3845	ABC transporter
SROS_RS06105	COG1079	Belongs to the binding-protein-dependent transport system permease family
SROS_RS06110	COG1079	Belongs to the binding-protein-dependent transport system permease family
SROS_RS06145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SROS_RS06160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SROS_RS06190	COG1501	Belongs to the glycosyl hydrolase 31 family
SROS_RS06200	COG0789	Transcriptional regulator
SROS_RS06205	COG0395	ABC-type sugar transport system, permease component
SROS_RS06210	COG4209	transmembrane transport
SROS_RS06220	COG1846	Transcriptional regulator
SROS_RS06220	COG1940	carbohydrate kinase activity
SROS_RS06240	COG4770	biotin carboxylase activity
SROS_RS06255	COG0433	COG0433 Predicted ATPase
SROS_RS06255	COG1674	ftsk spoiiie
SROS_RS06335	COG1432	Conserved Protein
SROS_RS06340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SROS_RS06345	COG1131	(ABC) transporter
SROS_RS06355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SROS_RS06365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SROS_RS06370	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SROS_RS06370	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SROS_RS06380	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SROS_RS06395	COG2193	ferroxidase activity
SROS_RS06400	COG0745	RESPONSE REGULATOR receiver
SROS_RS06405	COG2205	protein histidine kinase activity
SROS_RS06445	COG1280	lysine exporter protein (LysE YggA)
SROS_RS06450	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SROS_RS06470	COG1316	TRANSCRIPTIONal
SROS_RS06505	COG0371	Dehydrogenase
SROS_RS06515	COG1216	Glycosyl transferase, family 2
SROS_RS06575	COG0438	transferase activity, transferring glycosyl groups
SROS_RS06585	COG2226	methyltransferase
SROS_RS06595	COG0438	transferase activity, transferring glycosyl groups
SROS_RS06610	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SROS_RS06625	COG0778	Nitroreductase
SROS_RS06625	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SROS_RS06630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SROS_RS06670	COG2222	sugar isomerase
SROS_RS06685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SROS_RS06690	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SROS_RS06715	COG1609	Transcriptional regulator
SROS_RS06720	COG1129	ABC transporter
SROS_RS06725	COG1172	Belongs to the binding-protein-dependent transport system permease family
SROS_RS06735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SROS_RS06740	COG1869	D-ribose catabolic process
SROS_RS06760	COG0714	Associated with various cellular activities
SROS_RS06785	COG5002	protein histidine kinase activity
SROS_RS06790	COG5401	PFAM Sporulation and spore germination
SROS_RS06795	COG1040	competence protein
SROS_RS06800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SROS_RS06805	COG2197	response regulator
SROS_RS06810	COG3214	Protein conserved in bacteria
SROS_RS06820	COG0653	protein targeting
SROS_RS06830	COG1263	PTS System
SROS_RS06835	COG1263	PTS System
SROS_RS06840	COG2188	Transcriptional regulator
SROS_RS06845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SROS_RS06850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SROS_RS06865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SROS_RS06865	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SROS_RS06870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SROS_RS06875	COG1472	Belongs to the glycosyl hydrolase 3 family
SROS_RS06880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SROS_RS06895	COG1011	Hydrolase
SROS_RS06925	COG0583	DNA-binding transcription factor activity
SROS_RS06935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SROS_RS06945	COG2197	response regulator
SROS_RS06950	COG4585	Histidine kinase
SROS_RS06955	COG0277	FAD linked oxidase domain protein
SROS_RS06960	COG2902	Dehydrogenase
SROS_RS06970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SROS_RS06980	COG2884	Cell division ATP-binding protein ftsE
SROS_RS06990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SROS_RS07010	COG0667	Aldo Keto reductase
SROS_RS07035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SROS_RS07050	COG1960	acyl-CoA dehydrogenase activity
SROS_RS07065	COG4981	capsule polysaccharide biosynthetic process
SROS_RS07075	COG0500	methyltransferase
SROS_RS07090	COG2070	2-Nitropropane dioxygenase
SROS_RS07130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SROS_RS07175	COG3866	Pectate lyase
SROS_RS07180	COG1653	transport
SROS_RS07195	COG4948	Mandelate Racemase Muconate Lactonizing
SROS_RS07200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SROS_RS07205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SROS_RS07210	COG0395	ABC-type sugar transport system, permease component
SROS_RS07220	COG1609	Transcriptional regulator
SROS_RS07230	COG1280	lysine exporter protein (LysE YggA)
SROS_RS07240	COG1129	ABC transporter
SROS_RS07245	COG0583	DNA-binding transcription factor activity
SROS_RS07260	COG1842	Phage shock protein A
SROS_RS07300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SROS_RS07305	COG0686	Belongs to the AlaDH PNT family
SROS_RS07320	COG2197	response regulator
SROS_RS07325	COG4585	Histidine kinase
SROS_RS07330	COG0405	Gamma-glutamyltransferase
SROS_RS07370	COG0183	Belongs to the thiolase family
SROS_RS07400	COG0477	Major facilitator Superfamily
SROS_RS07430	COG0183	Belongs to the thiolase family
SROS_RS07445	COG0745	RESPONSE REGULATOR receiver
SROS_RS07450	COG2205	protein histidine kinase activity
SROS_RS07465	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SROS_RS07500	COG2197	response regulator
SROS_RS07520	COG1309	transcriptional regulator
SROS_RS07525	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS07560	COG0601	transmembrane transport
SROS_RS07580	COG1017	nitric oxide dioxygenase activity
SROS_RS07580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SROS_RS07610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SROS_RS07625	COG2255	four-way junction helicase activity
SROS_RS07650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SROS_RS07685	COG3903	Transcriptional regulator
SROS_RS07685	COG3629	intracellular signal transduction
SROS_RS07725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SROS_RS07725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SROS_RS07770	COG0789	Transcriptional regulator
SROS_RS07775	COG5504	Zn-dependent protease
SROS_RS07795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SROS_RS07800	COG0395	ABC-type sugar transport system, permease component
SROS_RS07805	COG1175	transmembrane transport
SROS_RS07810	COG1653	transport
SROS_RS07815	COG1653	transport
SROS_RS07825	COG0577	efflux transmembrane transporter activity
SROS_RS07825	COG1136	(ABC) transporter
SROS_RS07860	COG0018	arginyl-trna synthetase
SROS_RS07865	COG0019	diaminopimelate decarboxylase activity
SROS_RS07870	COG0460	homoserine dehydrogenase
SROS_RS07905	COG0463	Glycosyl transferase, family 2
SROS_RS07915	COG0477	Major facilitator Superfamily
SROS_RS07925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SROS_RS07930	COG0083	homoserine kinase activity
SROS_RS07955	COG0254	rRNA binding
SROS_RS07960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SROS_RS07965	COG2890	protein-(glutamine-N5) methyltransferase activity
SROS_RS07985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SROS_RS07990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SROS_RS08010	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SROS_RS08015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SROS_RS08020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SROS_RS08025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SROS_RS08030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SROS_RS08035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SROS_RS08040	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SROS_RS08060	COG0793	Belongs to the peptidase S41A family
SROS_RS08060	COG4946	Tricorn protease homolog
SROS_RS08065	COG1131	(ABC) transporter
SROS_RS08080	COG2197	response regulator
SROS_RS08085	COG1366	Belongs to the anti-sigma-factor antagonist family
SROS_RS08100	COG2197	response regulator
SROS_RS08105	COG4585	Histidine kinase
SROS_RS08120	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SROS_RS08125	COG1250	3-hydroxyacyl-CoA dehydrogenase
SROS_RS08145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SROS_RS08150	COG0628	permease
SROS_RS08165	COG0183	Belongs to the thiolase family
SROS_RS08195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SROS_RS08195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SROS_RS08205	COG1102	Psort location Cytoplasmic, score
SROS_RS08205	COG1904	glucuronate isomerase
SROS_RS08230	COG1678	Uncharacterized ACR, COG1678
SROS_RS08235	COG1309	transcriptional regulator
SROS_RS08240	COG0477	Major facilitator Superfamily
SROS_RS08265	COG2814	Major facilitator Superfamily
SROS_RS08285	COG1335	isochorismatase
SROS_RS08295	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SROS_RS08340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SROS_RS08345	COG1234	tRNA 3'-trailer cleavage
SROS_RS08350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SROS_RS08355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SROS_RS08400	COG0577	efflux transmembrane transporter activity
SROS_RS08400	COG1136	(ABC) transporter
SROS_RS08405	COG2197	response regulator
SROS_RS08410	COG4585	Histidine kinase
SROS_RS08450	COG1760	l-serine dehydratase
SROS_RS08455	COG0509	glycine decarboxylation via glycine cleavage system
SROS_RS08460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SROS_RS08465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SROS_RS08475	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS08485	COG2186	Transcriptional regulator
SROS_RS08525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SROS_RS08535	COG1132	(ABC) transporter
SROS_RS08540	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SROS_RS08565	COG4221	oxidoreductase activity
SROS_RS08580	COG1228	amidohydrolase
SROS_RS08585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SROS_RS08595	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SROS_RS08610	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SROS_RS08635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SROS_RS08650	COG4176	ABC-type proline glycine betaine transport system permease component
SROS_RS08655	COG4175	Glycine betaine
SROS_RS08655	COG3448	diguanylate cyclase activity
SROS_RS08660	COG5002	protein histidine kinase activity
SROS_RS08685	COG1176	ABC-type spermidine putrescine transport system, permease component I
SROS_RS08690	COG1177	transmembrane transport
SROS_RS08705	COG1819	glycosyl
SROS_RS08710	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS08725	COG2018	Roadblock/LC7 domain
SROS_RS08740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SROS_RS08745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SROS_RS08760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SROS_RS08760	COG1116	anion transmembrane transporter activity
SROS_RS08765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SROS_RS08780	COG5002	protein histidine kinase activity
SROS_RS08785	COG2018	Roadblock/LC7 domain
SROS_RS08810	COG0228	four-way junction DNA binding
SROS_RS08815	COG1837	Belongs to the UPF0109 family
SROS_RS08820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SROS_RS08825	COG0336	Belongs to the RNA methyltransferase TrmD family
SROS_RS08830	COG0335	large ribosomal subunit rRNA binding
SROS_RS08835	COG0681	Belongs to the peptidase S26 family
SROS_RS08845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SROS_RS08855	COG0792	nuclease activity
SROS_RS08880	COG2188	Transcriptional regulator
SROS_RS08985	COG0052	Belongs to the universal ribosomal protein uS2 family
SROS_RS08990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SROS_RS08995	COG0528	UMP kinase activity
SROS_RS09000	COG0233	cytoplasmic translational termination
SROS_RS09005	COG0575	Belongs to the CDS family
SROS_RS09015	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SROS_RS09020	COG0017	Asparaginyl-tRNA synthetase
SROS_RS09065	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS09070	COG3842	ATPase activity
SROS_RS09080	COG1176	ABC-type spermidine putrescine transport system, permease component I
SROS_RS09085	COG1177	transmembrane transport
SROS_RS09090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SROS_RS09095	COG1073	alpha beta
SROS_RS09105	COG2311	Membrane
SROS_RS09110	COG0475	glutathione-regulated potassium exporter activity
SROS_RS09120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SROS_RS09135	COG0574	Belongs to the PEP-utilizing enzyme family
SROS_RS09135	COG3848	Pyruvate phosphate dikinase
SROS_RS09190	COG0438	transferase activity, transferring glycosyl groups
SROS_RS09210	COG4585	Histidine kinase
SROS_RS09220	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SROS_RS09245	COG0778	Nitroreductase
SROS_RS09255	COG3469	chitinase activity
SROS_RS09280	COG1140	nitrate reductase beta subunit
SROS_RS09315	COG0384	phenazine biosynthesis protein PhzF
SROS_RS09330	COG1136	(ABC) transporter
SROS_RS09335	COG0577	efflux transmembrane transporter activity
SROS_RS09340	COG4585	Histidine kinase
SROS_RS09345	COG2197	response regulator
SROS_RS09350	COG0628	permease
SROS_RS09390	COG2205	protein histidine kinase activity
SROS_RS09390	COG3437	response regulator, receiver
SROS_RS09390	COG3850	Histidine kinase
SROS_RS09390	COG4999	Histidine kinase
SROS_RS09405	COG0477	Major facilitator Superfamily
SROS_RS09410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SROS_RS09420	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SROS_RS09455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SROS_RS09470	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS09495	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SROS_RS09500	COG0596	Alpha beta hydrolase
SROS_RS09525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS09550	COG1309	transcriptional regulator
SROS_RS09555	COG2409	Drug exporters of the RND superfamily
SROS_RS09560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SROS_RS09595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SROS_RS09600	COG1960	acyl-CoA dehydrogenase activity
SROS_RS09605	COG1960	acyl-CoA dehydrogenase activity
SROS_RS09610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS09650	COG2815	serine threonine protein kinase
SROS_RS09650	COG0515	serine threonine protein kinase
SROS_RS09660	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS09665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SROS_RS09670	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SROS_RS09675	COG1309	transcriptional regulator
SROS_RS09680	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS09685	COG2272	Belongs to the type-B carboxylesterase lipase family
SROS_RS09695	COG1735	metal-dependent hydrolase with the TIM-barrel fold
SROS_RS09735	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
SROS_RS09755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS09795	COG0789	Transcriptional regulator
SROS_RS09800	COG2814	Major facilitator Superfamily
SROS_RS09845	COG1378	Sugar-specific transcriptional regulator TrmB
SROS_RS09865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SROS_RS09880	COG4821	SIS domain
SROS_RS09885	COG1653	transport
SROS_RS09890	COG1175	transmembrane transport
SROS_RS09895	COG0395	ABC-type sugar transport system, permease component
SROS_RS09930	COG0183	Belongs to the thiolase family
SROS_RS09945	COG2814	Major facilitator Superfamily
SROS_RS09955	COG1472	Belongs to the glycosyl hydrolase 3 family
SROS_RS09975	COG1024	Enoyl-CoA hydratase
SROS_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS09995	COG1595	DNA-templated transcription, initiation
SROS_RS10055	COG0747	negative chemotaxis
SROS_RS10065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS10075	COG4608	Belongs to the ABC transporter superfamily
SROS_RS10095	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS10100	COG1960	acyl-CoA dehydrogenase activity
SROS_RS10125	COG2188	Transcriptional regulator
SROS_RS10145	COG0493	'glutamate synthase
SROS_RS10170	COG1960	acyl-CoA dehydrogenase activity
SROS_RS10180	COG0442	prolyl-tRNA aminoacylation
SROS_RS10215	COG0779	Required for maturation of 30S ribosomal subunits
SROS_RS10220	COG0195	Participates in both transcription termination and antitermination
SROS_RS10240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SROS_RS10245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SROS_RS10250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SROS_RS10255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SROS_RS10260	COG2186	Transcriptional regulator
SROS_RS10275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS10290	COG4608	Belongs to the ABC transporter superfamily
SROS_RS10300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SROS_RS10305	COG1185	polyribonucleotide nucleotidyltransferase activity
SROS_RS10310	COG0612	Peptidase, M16
SROS_RS10315	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SROS_RS10320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SROS_RS10320	COG2755	lipolytic protein G-D-S-L family
SROS_RS10330	COG0646	methionine synthase
SROS_RS10330	COG1410	methionine synthase
SROS_RS10335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SROS_RS10340	COG2508	Transcriptional regulator
SROS_RS10340	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SROS_RS10345	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SROS_RS10380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS10410	COG3619	membrane
SROS_RS10420	COG0693	protein deglycase activity
SROS_RS10440	COG2188	Transcriptional regulator
SROS_RS10450	COG2003	Belongs to the UPF0758 family
SROS_RS10470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SROS_RS10480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SROS_RS10485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SROS_RS10490	COG1414	Transcriptional regulator
SROS_RS10495	COG1674	ftsk spoiiie
SROS_RS10505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SROS_RS10515	COG1058	Belongs to the CinA family
SROS_RS10515	COG1546	Belongs to the CinA family
SROS_RS10520	COG1396	sequence-specific DNA binding
SROS_RS10525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SROS_RS10540	COG1940	carbohydrate kinase activity
SROS_RS10555	COG1472	Belongs to the glycosyl hydrolase 3 family
SROS_RS10575	COG2814	Major facilitator Superfamily
SROS_RS10585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SROS_RS10600	COG0395	ABC-type sugar transport system, permease component
SROS_RS10605	COG1175	transmembrane transport
SROS_RS10610	COG1653	transport
SROS_RS10665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SROS_RS10675	COG0508	dehydrogenase complex catalyzes the overall conversion of
SROS_RS10685	COG1309	transcriptional regulator
SROS_RS10695	COG1201	RNA secondary structure unwinding
SROS_RS10705	COG0346	lactoylglutathione lyase activity
SROS_RS10720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SROS_RS10725	COG2137	regulation of response to DNA damage stimulus
SROS_RS10730	COG1418	mRNA catabolic process
SROS_RS10740	COG0765	amino acid transport
SROS_RS10745	COG0765	amino acid transport
SROS_RS10750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SROS_RS10755	COG1126	abc transporter atp-binding protein
SROS_RS10765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SROS_RS10785	COG1234	tRNA 3'-trailer cleavage
SROS_RS10790	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
SROS_RS10805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SROS_RS10810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SROS_RS10820	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS10850	COG0745	RESPONSE REGULATOR receiver
SROS_RS10885	COG3119	arylsulfatase activity
SROS_RS10895	COG1609	Transcriptional regulator
SROS_RS10905	COG1175	transmembrane transport
SROS_RS10910	COG1653	transport
SROS_RS10920	COG1414	Transcriptional regulator
SROS_RS10925	COG0247	lactate metabolic process
SROS_RS10930	COG0277	FAD linked oxidase domain protein
SROS_RS10935	COG0277	FAD linked oxidase domain protein
SROS_RS10940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SROS_RS10950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SROS_RS10955	COG0745	RESPONSE REGULATOR receiver
SROS_RS10960	COG2205	protein histidine kinase activity
SROS_RS10960	COG0784	Response regulator, receiver
SROS_RS10970	COG2172	sigma factor antagonist activity
SROS_RS10975	COG1366	Belongs to the anti-sigma-factor antagonist family
SROS_RS10980	COG1366	Belongs to the anti-sigma-factor antagonist family
SROS_RS10990	COG1228	amidohydrolase
SROS_RS10995	COG1307	EDD domain protein, DegV family
SROS_RS11000	COG1596	polysaccharide export
SROS_RS11000	COG1555	photosystem II stabilization
SROS_RS11025	COG0697	spore germination
SROS_RS11030	COG1846	Transcriptional regulator
SROS_RS11035	COG0268	Binds directly to 16S ribosomal RNA
SROS_RS11045	COG0481	GTPase activity
SROS_RS11075	COG1420	regulation of RNA biosynthetic process
SROS_RS11080	COG0484	heat shock protein binding
SROS_RS11100	COG0537	adenosine 5'-monophosphoramidase activity
SROS_RS11110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SROS_RS11130	COG2197	response regulator
SROS_RS11145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SROS_RS11180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SROS_RS11185	COG4978	Transcriptional regulator
SROS_RS11185	COG0789	Transcriptional regulator
SROS_RS11195	COG0277	FAD linked oxidase domain protein
SROS_RS11200	COG1764	response to oxidative stress
SROS_RS11210	COG1846	Transcriptional regulator
SROS_RS11250	COG0531	amino acid
SROS_RS11260	COG1846	Transcriptional regulator
SROS_RS11265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SROS_RS11280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SROS_RS11285	COG1834	amidinotransferase
SROS_RS11305	COG1381	Involved in DNA repair and RecF pathway recombination
SROS_RS11310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SROS_RS11315	COG1024	Enoyl-CoA hydratase
SROS_RS11335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SROS_RS11340	COG1121	(ABC) transporter
SROS_RS11345	COG0803	Belongs to the bacterial solute-binding protein 9 family
SROS_RS11345	COG3443	Belongs to the bacterial solute-binding protein 9 family
SROS_RS11360	COG0423	glycine-tRNA ligase activity
SROS_RS11365	COG0574	Belongs to the PEP-utilizing enzyme family
SROS_RS11365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SROS_RS11370	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SROS_RS11380	COG0358	DNA primase activity
SROS_RS11385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SROS_RS11390	COG2822	iron ion transport
SROS_RS11395	COG2837	iron assimilation
SROS_RS11400	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SROS_RS11420	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
SROS_RS11445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SROS_RS11455	COG1175	transmembrane transport
SROS_RS11460	COG0395	ABC-type sugar transport system, permease component
SROS_RS11470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SROS_RS11520	COG1024	Enoyl-CoA hydratase
SROS_RS11530	COG0435	Glutathione S-transferase
SROS_RS11550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS11560	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SROS_RS11600	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
SROS_RS11655	COG1401	restriction endodeoxyribonuclease activity
SROS_RS11695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SROS_RS11700	COG1830	Aldolase
SROS_RS11715	COG1129	ABC transporter
SROS_RS11725	COG2188	Transcriptional regulator
SROS_RS11745	COG3251	PFAM MbtH domain protein
SROS_RS11785	COG3903	Transcriptional regulator
SROS_RS11785	COG3629	intracellular signal transduction
SROS_RS11790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SROS_RS11805	COG1113	amino acid transport
SROS_RS11815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SROS_RS11820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SROS_RS11830	COG0667	Aldo Keto reductase
SROS_RS11855	COG0671	phosphoesterase, PA-phosphatase related
SROS_RS11860	COG2197	response regulator
SROS_RS11865	COG4585	Histidine kinase
SROS_RS11870	COG3507	Belongs to the glycosyl hydrolase 43 family
SROS_RS11895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SROS_RS11920	COG0859	PFAM glycosyl transferase family 9
SROS_RS11930	COG0859	PFAM glycosyl transferase family 9
SROS_RS11960	COG1846	Transcriptional regulator
SROS_RS11960	COG1940	carbohydrate kinase activity
SROS_RS11965	COG3618	amidohydrolase
SROS_RS11975	COG0747	negative chemotaxis
SROS_RS11980	COG0601	transmembrane transport
SROS_RS11985	COG0444	Belongs to the ABC transporter superfamily
SROS_RS11990	COG4608	Belongs to the ABC transporter superfamily
SROS_RS11995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SROS_RS12005	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SROS_RS12035	COG4336	lyase activity
SROS_RS12050	COG1609	Transcriptional regulator
SROS_RS12075	COG1735	metal-dependent hydrolase with the TIM-barrel fold
SROS_RS12115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SROS_RS12130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SROS_RS12150	COG2197	response regulator
SROS_RS12160	COG1131	(ABC) transporter
SROS_RS12200	COG0406	alpha-ribazole phosphatase activity
SROS_RS12235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS12240	COG1120	ATPase activity
SROS_RS12270	COG0515	serine threonine protein kinase
SROS_RS12270	COG2815	serine threonine protein kinase
SROS_RS12280	COG2197	response regulator
SROS_RS12290	COG2910	NAD(P)H-binding
SROS_RS12350	COG1131	(ABC) transporter
SROS_RS12370	COG1476	TRANSCRIPTIONal
SROS_RS12390	COG0180	Tryptophanyl-tRNA synthetase
SROS_RS12415	COG1132	(ABC) transporter
SROS_RS12430	COG0686	Belongs to the AlaDH PNT family
SROS_RS12440	COG2252	PERMEase
SROS_RS12445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SROS_RS12465	COG3336	cytochrome c oxidase
SROS_RS12525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS12535	COG5634	Uncharacterized conserved protein (DUF2278)
SROS_RS12540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SROS_RS12545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SROS_RS12555	COG0477	Major facilitator Superfamily
SROS_RS12580	COG1309	transcriptional regulator
SROS_RS12600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SROS_RS12600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SROS_RS12610	COG4585	Histidine kinase
SROS_RS12620	COG4585	Histidine kinase
SROS_RS12625	COG0477	Major facilitator Superfamily
SROS_RS12650	COG0174	glutamine synthetase
SROS_RS12680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SROS_RS12680	COG0519	Catalyzes the synthesis of GMP from XMP
SROS_RS12685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SROS_RS12705	COG0791	NLP P60 protein
SROS_RS12745	COG2226	methyltransferase
SROS_RS12775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SROS_RS12780	COG0321	lipoyl(octanoyl) transferase activity
SROS_RS12800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SROS_RS12805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SROS_RS12810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS12825	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SROS_RS12840	COG0667	Aldo Keto reductase
SROS_RS12865	COG0501	Belongs to the peptidase M48B family
SROS_RS12885	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SROS_RS12885	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SROS_RS12900	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SROS_RS12910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SROS_RS12925	COG1104	cysteine desulfurase activity
SROS_RS12930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SROS_RS12935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SROS_RS12945	COG1376	ErfK ybiS ycfS ynhG family protein
SROS_RS12950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SROS_RS12955	COG0723	plastoquinol--plastocyanin reductase activity
SROS_RS12960	COG2010	Cytochrome c
SROS_RS12965	COG1845	cytochrome c oxidase, subunit III
SROS_RS12975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SROS_RS12980	COG4585	Histidine kinase
SROS_RS13015	COG1704	LemA family
SROS_RS13035	COG0741	lytic transglycosylase activity
SROS_RS13035	COG0791	NLP P60 protein
SROS_RS13045	COG0501	Belongs to the peptidase M48B family
SROS_RS13050	COG0438	transferase activity, transferring glycosyl groups
SROS_RS13070	COG0003	Pfam Anion-transporting ATPase
SROS_RS13080	COG1940	carbohydrate kinase activity
SROS_RS13110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SROS_RS13115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SROS_RS13130	COG4413	Urea transporter
SROS_RS13145	COG0832	Belongs to the urease beta subunit family
SROS_RS13145	COG0831	urea catabolic process
SROS_RS13150	COG0804	urea catabolic process
SROS_RS13155	COG0830	nickel cation binding
SROS_RS13160	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SROS_RS13165	COG0829	nickel cation binding
SROS_RS13170	COG1609	Transcriptional regulator
SROS_RS13175	COG3458	cephalosporin-C deacetylase activity
SROS_RS13180	COG0640	Transcriptional regulator
SROS_RS13225	COG2267	carboxylic ester hydrolase activity
SROS_RS13235	COG1309	transcriptional regulator
SROS_RS13265	COG2040	homocysteine
SROS_RS13300	COG1902	pentaerythritol trinitrate reductase activity
SROS_RS13310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS13315	COG1309	transcriptional regulator
SROS_RS13320	COG2409	Drug exporters of the RND superfamily
SROS_RS13325	COG0456	acetyltransferase
SROS_RS13325	COG1846	Transcriptional regulator
SROS_RS13335	COG0205	6-phosphofructokinase activity
SROS_RS13340	COG5001	Diguanylate cyclase
SROS_RS13340	COG3300	MHYT domain
SROS_RS13350	COG0301	tRNA thio-modification
SROS_RS13355	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SROS_RS13360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SROS_RS13365	COG3275	phosphorelay sensor kinase activity
SROS_RS13370	COG3279	Response regulator of the LytR AlgR family
SROS_RS13390	COG0477	Major facilitator Superfamily
SROS_RS13395	COG0804	urea catabolic process
SROS_RS13400	COG0831	urea catabolic process
SROS_RS13400	COG0832	Belongs to the urease beta subunit family
SROS_RS13410	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SROS_RS13445	COG1929	Belongs to the glycerate kinase type-1 family
SROS_RS13450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SROS_RS13455	COG4266	Belongs to the allantoicase family
SROS_RS13460	COG2815	serine threonine protein kinase
SROS_RS13460	COG0515	serine threonine protein kinase
SROS_RS13465	COG2022	thiamine diphosphate biosynthetic process
SROS_RS13475	COG2022	thiamine diphosphate biosynthetic process
SROS_RS13475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SROS_RS13490	COG0352	thiamine-phosphate diphosphorylase activity
SROS_RS13495	COG0142	geranyltranstransferase activity
SROS_RS13505	COG0456	acetyltransferase
SROS_RS13545	COG0531	amino acid
SROS_RS13550	COG0549	Belongs to the carbamate kinase family
SROS_RS13555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SROS_RS13565	COG0531	amino acid
SROS_RS13575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SROS_RS13580	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SROS_RS13585	COG0540	Belongs to the ATCase OTCase family
SROS_RS13590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SROS_RS13595	COG0505	Belongs to the CarA family
SROS_RS13600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SROS_RS13605	COG0543	2 iron, 2 sulfur cluster binding
SROS_RS13610	COG0167	dihydroorotate dehydrogenase activity
SROS_RS13615	COG0284	orotidine-5'-phosphate decarboxylase activity
SROS_RS13625	COG0194	GDP metabolic process
SROS_RS13630	COG1758	RNA polymerase activity
SROS_RS13650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SROS_RS13665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SROS_RS13680	COG0242	peptide deformylase activity
SROS_RS13685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SROS_RS13710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SROS_RS13735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SROS_RS13735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SROS_RS13740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SROS_RS13755	COG0745	RESPONSE REGULATOR receiver
SROS_RS13765	COG0569	domain protein
SROS_RS13770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SROS_RS13775	COG0542	response to heat
SROS_RS13785	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SROS_RS13785	COG3608	succinylglutamate desuccinylase aspartoacylase
SROS_RS13800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS13805	COG1301	dicarboxylic acid transport
SROS_RS13815	COG0006	proline dipeptidase activity
SROS_RS13820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SROS_RS13825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SROS_RS13835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SROS_RS13855	COG0714	Associated with various cellular activities
SROS_RS13860	COG2001	Belongs to the MraZ family
SROS_RS13865	COG0275	rRNA processing
SROS_RS13875	COG0768	penicillin binding
SROS_RS13880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SROS_RS13890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SROS_RS13895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SROS_RS13905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SROS_RS13910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SROS_RS13915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SROS_RS13920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SROS_RS13930	COG1799	cell septum assembly
SROS_RS13940	COG3599	regulation of cell shape
SROS_RS13950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SROS_RS13960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SROS_RS13990	COG0515	serine threonine protein kinase
SROS_RS13990	COG2815	serine threonine protein kinase
SROS_RS13995	COG0515	serine threonine protein kinase
SROS_RS14010	COG1113	amino acid transport
SROS_RS14015	COG0587	DNA-directed DNA polymerase activity
SROS_RS14045	COG0438	transferase activity, transferring glycosyl groups
SROS_RS14055	COG1595	DNA-templated transcription, initiation
SROS_RS14065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SROS_RS14070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SROS_RS14085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SROS_RS14090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SROS_RS14095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SROS_RS14100	COG0131	Imidazoleglycerol-phosphate dehydratase
SROS_RS14105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SROS_RS14115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SROS_RS14125	COG0107	imidazoleglycerol-phosphate synthase activity
SROS_RS14150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SROS_RS14190	COG1132	(ABC) transporter
SROS_RS14200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SROS_RS14210	COG0765	amino acid transport
SROS_RS14215	COG2326	polyphosphate kinase activity
SROS_RS14220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SROS_RS14240	COG0134	indole-3-glycerol-phosphate synthase activity
SROS_RS14245	COG0133	tryptophan synthase activity
SROS_RS14250	COG0159	tryptophan synthase activity
SROS_RS14265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SROS_RS14290	COG0069	glutamate synthase activity
SROS_RS14290	COG0070	glutamate synthase
SROS_RS14290	COG0067	glutamate synthase
SROS_RS14360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SROS_RS14365	COG0765	amino acid transport
SROS_RS14375	COG2050	protein possibly involved in aromatic compounds catabolism
SROS_RS14390	COG0539	negative regulation of cytoplasmic translation
SROS_RS14400	COG0237	dephospho-CoA kinase activity
SROS_RS14405	COG0596	Alpha beta hydrolase
SROS_RS14410	COG2378	regulation of single-species biofilm formation
SROS_RS14415	COG5635	Nacht domain
SROS_RS14415	COG2319	Wd-40 repeat
SROS_RS14425	COG0483	inositol monophosphate 1-phosphatase activity
SROS_RS14455	COG0556	nucleotide-excision repair
SROS_RS14480	COG2070	2-Nitropropane dioxygenase
SROS_RS14485	COG0110	maltose O-acetyltransferase activity
SROS_RS14490	COG0504	CTP synthase activity
SROS_RS14495	COG0494	nUDIX hydrolase
SROS_RS14510	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SROS_RS14515	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SROS_RS14535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SROS_RS14540	COG1160	GTP binding
SROS_RS14560	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS14570	COG0583	DNA-binding transcription factor activity
SROS_RS14580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SROS_RS14600	COG0778	Nitroreductase
SROS_RS14650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SROS_RS14655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SROS_RS14660	COG0006	proline dipeptidase activity
SROS_RS14695	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SROS_RS14700	COG1404	Belongs to the peptidase S8 family
SROS_RS14705	COG4608	Belongs to the ABC transporter superfamily
SROS_RS14710	COG0444	Belongs to the ABC transporter superfamily
SROS_RS14715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS14760	COG1461	Dihydroxyacetone kinase
SROS_RS14765	COG2376	Dihydroxyacetone kinase
SROS_RS14780	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SROS_RS14785	COG0028	Belongs to the TPP enzyme family
SROS_RS14805	COG0412	Dienelactone hydrolase
SROS_RS14825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SROS_RS14830	COG1940	carbohydrate kinase activity
SROS_RS14835	COG3119	arylsulfatase activity
SROS_RS14855	COG1120	ATPase activity
SROS_RS14860	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS14865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS14870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SROS_RS14880	COG0395	ABC-type sugar transport system, permease component
SROS_RS14885	COG1175	transmembrane transport
SROS_RS14895	COG0673	inositol 2-dehydrogenase activity
SROS_RS14920	COG4821	SIS domain
SROS_RS14940	COG1917	Cupin 2, conserved barrel domain protein
SROS_RS14940	COG2207	Transcriptional regulator
SROS_RS14945	COG0179	Fumarylacetoacetate (FAA) hydrolase
SROS_RS15000	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS15005	COG0506	proline dehydrogenase activity
SROS_RS15060	COG1252	NADH dehydrogenase
SROS_RS15190	COG1720	tRNA m6t6A37 methyltransferase activity
SROS_RS15230	COG2207	Transcriptional regulator
SROS_RS15235	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SROS_RS15250	COG0248	Ppx GppA phosphatase
SROS_RS15265	COG2197	response regulator
SROS_RS15270	COG0747	negative chemotaxis
SROS_RS15280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS15285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS15295	COG1846	Transcriptional regulator
SROS_RS15310	COG1309	transcriptional regulator
SROS_RS15315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SROS_RS15350	COG0601	transmembrane transport
SROS_RS15355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS15365	COG2267	carboxylic ester hydrolase activity
SROS_RS15370	COG0444	Belongs to the ABC transporter superfamily
SROS_RS15375	COG4608	Belongs to the ABC transporter superfamily
SROS_RS15420	COG3842	ATPase activity
SROS_RS15430	COG0402	S-adenosylhomocysteine deaminase activity
SROS_RS15505	COG4585	Histidine kinase
SROS_RS15555	COG2326	polyphosphate kinase activity
SROS_RS15580	COG1597	lipid kinase activity
SROS_RS15595	COG3281	Trehalose synthase
SROS_RS15625	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SROS_RS15635	COG3540	Alkaline phosphatase
SROS_RS15660	COG0477	Major facilitator Superfamily
SROS_RS15685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SROS_RS15705	COG1309	transcriptional regulator
SROS_RS15710	COG5398	heme oxygenase
SROS_RS15730	COG4585	Histidine kinase
SROS_RS15735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SROS_RS15745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SROS_RS15750	COG2011	ABC-type metal ion transport system permease component
SROS_RS15760	COG2197	response regulator
SROS_RS15765	COG4585	Histidine kinase
SROS_RS15795	COG0539	negative regulation of cytoplasmic translation
SROS_RS15835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS15860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SROS_RS15880	COG4257	antibiotic catabolic process
SROS_RS15885	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SROS_RS15890	COG4988	ABC transporter
SROS_RS15900	COG1271	oxidase subunit
SROS_RS15935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SROS_RS15940	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SROS_RS15950	COG1595	DNA-templated transcription, initiation
SROS_RS15960	COG0590	tRNA wobble adenosine to inosine editing
SROS_RS15965	COG3224	Antibiotic biosynthesis monooxygenase
SROS_RS15990	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SROS_RS15995	COG2226	methyltransferase
SROS_RS16010	COG3001	Fructosamine kinase
SROS_RS16015	COG2017	converts alpha-aldose to the beta-anomer
SROS_RS16030	COG0395	ABC-type sugar transport system, permease component
SROS_RS16035	COG1175	transmembrane transport
SROS_RS16040	COG1653	transport
SROS_RS16050	COG1309	transcriptional regulator
SROS_RS16055	COG4221	oxidoreductase activity
SROS_RS16080	COG1216	Glycosyl transferase, family 2
SROS_RS16080	COG1442	glycosyl transferase family 8
SROS_RS16085	COG2089	acid synthase
SROS_RS16135	COG3833	ABC-type maltose transport systems, permease component
SROS_RS16150	COG4585	Histidine kinase
SROS_RS16155	COG2197	response regulator
SROS_RS16160	COG0506	proline dehydrogenase activity
SROS_RS16180	COG1874	Beta-galactosidase
SROS_RS16180	COG0366	Alpha amylase catalytic
SROS_RS16200	COG1175	transmembrane transport
SROS_RS16205	COG3833	ABC-type maltose transport systems, permease component
SROS_RS16210	COG0366	Alpha amylase catalytic
SROS_RS16220	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS16250	COG3842	ATPase activity
SROS_RS16260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SROS_RS16265	COG2814	Major facilitator Superfamily
SROS_RS16275	COG1522	sequence-specific DNA binding
SROS_RS16300	COG1309	transcriptional regulator
SROS_RS16355	COG0800	Aldolase
SROS_RS16360	COG0837	glucose binding
SROS_RS16365	COG0129	dihydroxy-acid dehydratase activity
SROS_RS16370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SROS_RS16375	COG1940	carbohydrate kinase activity
SROS_RS16405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SROS_RS16510	COG0740	serine-type endopeptidase activity
SROS_RS16520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SROS_RS16565	COG1404	Belongs to the peptidase S8 family
SROS_RS16600	COG2211	Major facilitator Superfamily
SROS_RS16620	COG0745	RESPONSE REGULATOR receiver
SROS_RS16665	COG3903	Transcriptional regulator
SROS_RS16665	COG3629	intracellular signal transduction
SROS_RS16685	COG1131	(ABC) transporter
SROS_RS16720	COG1119	ATPase activity
SROS_RS16730	COG0776	regulation of translation
SROS_RS16760	COG0463	Glycosyl transferase, family 2
SROS_RS16780	COG2815	serine threonine protein kinase
SROS_RS16780	COG0515	serine threonine protein kinase
SROS_RS16785	COG1733	regulation of RNA biosynthetic process
SROS_RS16805	COG4941	Belongs to the sigma-70 factor family
SROS_RS16820	COG1120	ATPase activity
SROS_RS16825	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS16830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS16855	COG1132	(ABC) transporter
SROS_RS16870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SROS_RS16875	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS16915	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SROS_RS16940	COG2813	Specifically methylates the guanine in position
SROS_RS16945	COG3842	ATPase activity
SROS_RS16950	COG1063	alcohol dehydrogenase
SROS_RS16955	COG0395	ABC-type sugar transport system, permease component
SROS_RS16975	COG1404	Belongs to the peptidase S8 family
SROS_RS16975	COG4412	M6 family metalloprotease domain protein
SROS_RS17005	COG3938	Belongs to the proline racemase family
SROS_RS17025	COG2814	Major facilitator Superfamily
SROS_RS17030	COG4608	Belongs to the ABC transporter superfamily
SROS_RS17040	COG0601	transmembrane transport
SROS_RS17045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS17050	COG4166	transmembrane transport
SROS_RS17055	COG1959	2 iron, 2 sulfur cluster binding
SROS_RS17070	COG3291	Pkd domain containing protein
SROS_RS17085	COG2197	response regulator
SROS_RS17120	COG0589	response to stress
SROS_RS17125	COG4109	DRTGG domain
SROS_RS17135	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SROS_RS17145	COG0367	asparagine synthase
SROS_RS17150	COG2308	Evidence 4 Homologs of previously reported genes of
SROS_RS17150	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SROS_RS17170	COG0395	ABC-type sugar transport system, permease component
SROS_RS17175	COG1175	transmembrane transport
SROS_RS17180	COG1653	transport
SROS_RS17185	COG1940	carbohydrate kinase activity
SROS_RS17195	COG1846	Transcriptional regulator
SROS_RS17215	COG2267	carboxylic ester hydrolase activity
SROS_RS17220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SROS_RS17225	COG2124	cytochrome p450
SROS_RS17230	COG1309	transcriptional regulator
SROS_RS17255	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SROS_RS17255	COG1703	isobutyryl-CoA mutase activity
SROS_RS17255	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SROS_RS17260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SROS_RS17280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SROS_RS17285	COG0135	phosphoribosylanthranilate isomerase activity
SROS_RS17305	COG2318	DinB family
SROS_RS17320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SROS_RS17325	COG0539	negative regulation of cytoplasmic translation
SROS_RS17330	COG1595	DNA-templated transcription, initiation
SROS_RS17360	COG1966	Carbon starvation protein
SROS_RS17390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SROS_RS17400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS17420	COG1132	(ABC) transporter
SROS_RS17455	COG3387	PFAM Glycoside hydrolase 15-related
SROS_RS17495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SROS_RS17500	COG1522	sequence-specific DNA binding
SROS_RS17505	COG0477	Major facilitator Superfamily
SROS_RS17520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SROS_RS17525	COG0009	L-threonylcarbamoyladenylate synthase
SROS_RS17565	COG0583	DNA-binding transcription factor activity
SROS_RS17570	COG4974	Belongs to the 'phage' integrase family
SROS_RS17580	COG0183	Belongs to the thiolase family
SROS_RS17610	COG0667	Aldo Keto reductase
SROS_RS17645	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS17650	COG0477	Major facilitator Superfamily
SROS_RS17665	COG0789	Transcriptional regulator
SROS_RS17690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SROS_RS17755	COG3629	intracellular signal transduction
SROS_RS17755	COG3903	Transcriptional regulator
SROS_RS17760	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS17770	COG1181	Belongs to the D-alanine--D-alanine ligase family
SROS_RS17785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SROS_RS17800	COG2175	clavaminate synthase activity
SROS_RS17815	COG2197	response regulator
SROS_RS17820	COG4585	Histidine kinase
SROS_RS17845	COG1007	ATP synthesis coupled electron transport
SROS_RS17855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SROS_RS17870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SROS_RS17880	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SROS_RS17920	COG0596	Alpha beta hydrolase
SROS_RS17935	COG0583	DNA-binding transcription factor activity
SROS_RS17955	COG2608	mercury ion transmembrane transporter activity
SROS_RS17960	COG1937	Protein conserved in bacteria
SROS_RS17980	COG0531	amino acid
SROS_RS17995	COG2124	cytochrome p450
SROS_RS18005	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SROS_RS18010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SROS_RS18020	COG0142	geranyltranstransferase activity
SROS_RS18030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SROS_RS18035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS18045	COG3385	transposase activity
SROS_RS18080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS18085	COG1940	carbohydrate kinase activity
SROS_RS18090	COG3383	formate dehydrogenase (NAD+) activity
SROS_RS18090	COG0243	molybdopterin cofactor binding
SROS_RS18095	COG0243	molybdopterin cofactor binding
SROS_RS18095	COG3383	formate dehydrogenase (NAD+) activity
SROS_RS18100	COG0437	4 iron, 4 sulfur cluster binding
SROS_RS18110	COG0709	Synthesizes selenophosphate from selenide and ATP
SROS_RS18135	COG0477	Major facilitator Superfamily
SROS_RS18165	COG1063	alcohol dehydrogenase
SROS_RS18170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SROS_RS18175	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SROS_RS18180	COG2080	2 iron, 2 sulfur cluster binding
SROS_RS18210	COG0583	DNA-binding transcription factor activity
SROS_RS18220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SROS_RS18225	COG0019	diaminopimelate decarboxylase activity
SROS_RS18235	COG2175	clavaminate synthase activity
SROS_RS18245	COG0601	transmembrane transport
SROS_RS18250	COG4171	peptide transport system, permease
SROS_RS18255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SROS_RS18260	COG2197	response regulator
SROS_RS18265	COG0512	Glutamine amidotransferase of anthranilate synthase
SROS_RS18265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SROS_RS18275	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS18275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SROS_RS18290	COG3433	isochorismatase activity
SROS_RS18290	COG2226	methyltransferase
SROS_RS18290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SROS_RS18295	COG2226	methyltransferase
SROS_RS18295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SROS_RS18295	COG3433	isochorismatase activity
SROS_RS18320	COG2264	protein methyltransferase activity
SROS_RS18325	COG0259	pyridoxamine-phosphate oxidase activity
SROS_RS18330	COG1021	2,3-dihydroxybenzoate-AMP ligase
SROS_RS18335	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SROS_RS18380	COG1940	carbohydrate kinase activity
SROS_RS18390	COG1672	PFAM Archaeal ATPase
SROS_RS18390	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SROS_RS18420	COG3629	intracellular signal transduction
SROS_RS18420	COG3903	Transcriptional regulator
SROS_RS18435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SROS_RS18450	COG0675	Transposase, IS605 OrfB family
SROS_RS18455	COG4770	biotin carboxylase activity
SROS_RS18470	COG1132	(ABC) transporter
SROS_RS18475	COG1132	(ABC) transporter
SROS_RS18495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SROS_RS18500	COG1609	Transcriptional regulator
SROS_RS18505	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SROS_RS18520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SROS_RS18530	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SROS_RS18570	COG0409	Hydrogenase expression formation protein
SROS_RS18595	COG0416	fatty acid biosynthetic process
SROS_RS18605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SROS_RS18630	COG1309	transcriptional regulator
SROS_RS18650	COG0395	ABC-type sugar transport system, permease component
SROS_RS18655	COG1175	transmembrane transport
SROS_RS18670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SROS_RS18670	COG0352	thiamine-phosphate diphosphorylase activity
SROS_RS18670	COG0351	phosphomethylpyrimidine kinase
SROS_RS18690	COG4638	Rieske (2fe-2S)
SROS_RS18755	COG1846	Transcriptional regulator
SROS_RS18765	COG1366	Belongs to the anti-sigma-factor antagonist family
SROS_RS18770	COG4565	transcriptional regulatory protein
SROS_RS18775	COG3290	protein histidine kinase activity
SROS_RS18780	COG1301	dicarboxylic acid transport
SROS_RS18790	COG1764	response to oxidative stress
SROS_RS18795	COG1846	Transcriptional regulator
SROS_RS18810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS18820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS18825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS18830	COG0475	glutathione-regulated potassium exporter activity
SROS_RS18850	COG0714	Associated with various cellular activities
SROS_RS18865	COG3268	Saccharopine dehydrogenase
SROS_RS18920	COG1515	deoxyribonuclease V activity
SROS_RS18940	COG3541	Predicted nucleotidyltransferase
SROS_RS18965	COG2936	dipeptidyl-peptidase activity
SROS_RS18980	COG0714	Associated with various cellular activities
SROS_RS19005	COG0477	Major facilitator Superfamily
SROS_RS19045	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SROS_RS19055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SROS_RS19110	COG3293	Transposase
SROS_RS19125	COG0693	protein deglycase activity
SROS_RS19135	COG1309	transcriptional regulator
SROS_RS19140	COG0477	Major facilitator Superfamily
SROS_RS19150	COG0477	Major facilitator Superfamily
SROS_RS19205	COG0395	ABC-type sugar transport system, permease component
SROS_RS19210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SROS_RS19215	COG0515	serine threonine protein kinase
SROS_RS19215	COG2815	serine threonine protein kinase
SROS_RS19220	COG0438	transferase activity, transferring glycosyl groups
SROS_RS19225	COG1309	transcriptional regulator
SROS_RS19245	COG0604	alcohol dehydrogenase
SROS_RS19250	COG1476	TRANSCRIPTIONal
SROS_RS19300	COG0346	lactoylglutathione lyase activity
SROS_RS19310	COG3265	gluconokinase activity
SROS_RS19320	COG2235	arginine
SROS_RS19325	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS19355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SROS_RS19360	COG4644	lycopene metabolic process
SROS_RS19375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SROS_RS19410	COG2197	response regulator
SROS_RS19425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SROS_RS19450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SROS_RS19450	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SROS_RS19485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SROS_RS19495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SROS_RS19510	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SROS_RS19525	COG0443	Heat shock 70 kDa protein
SROS_RS19530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SROS_RS19545	COG0542	response to heat
SROS_RS19555	COG0492	ferredoxin-NADP+ reductase activity
SROS_RS19560	COG2197	response regulator
SROS_RS19565	COG2188	Transcriptional regulator
SROS_RS19595	COG1172	Belongs to the binding-protein-dependent transport system permease family
SROS_RS19615	COG2271	Major facilitator Superfamily
SROS_RS19650	COG1739	Uncharacterized protein family UPF0029
SROS_RS19655	COG0586	Pfam SNARE associated Golgi protein
SROS_RS19660	COG4585	Histidine kinase
SROS_RS19665	COG3279	Response regulator of the LytR AlgR family
SROS_RS19670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SROS_RS19675	COG1169	isochorismate synthase
SROS_RS19685	COG2197	response regulator
SROS_RS19690	COG4585	Histidine kinase
SROS_RS19710	COG4946	Tricorn protease homolog
SROS_RS19710	COG0793	Belongs to the peptidase S41A family
SROS_RS19730	COG1051	belongs to the nudix hydrolase family
SROS_RS19765	COG1309	transcriptional regulator
SROS_RS19770	COG2084	Dehydrogenase
SROS_RS19775	COG1309	transcriptional regulator
SROS_RS19780	COG1280	lysine exporter protein (LysE YggA)
SROS_RS19785	COG1280	lysine exporter protein (LysE YggA)
SROS_RS19820	COG2226	methyltransferase
SROS_RS19825	COG1609	Transcriptional regulator
SROS_RS19835	COG1309	transcriptional regulator
SROS_RS19855	COG0346	lactoylglutathione lyase activity
SROS_RS19865	COG3973	AAA domain
SROS_RS19865	COG3973	AAA domain
SROS_RS19880	COG2378	regulation of single-species biofilm formation
SROS_RS19935	COG0488	(ABC) transporter
SROS_RS19950	COG2249	NAD(P)H dehydrogenase (quinone) activity
SROS_RS19970	COG4585	Histidine kinase
SROS_RS19975	COG2197	response regulator
SROS_RS19995	COG0330	HflC and HflK could
SROS_RS20000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SROS_RS20015	COG0243	molybdopterin cofactor binding
SROS_RS20030	COG1595	DNA-templated transcription, initiation
SROS_RS20050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS20110	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS20115	COG2329	Antibiotic biosynthesis monooxygenase
SROS_RS20120	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS20125	COG1233	COG1233 Phytoene dehydrogenase and related
SROS_RS20145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SROS_RS20150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SROS_RS20155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SROS_RS20170	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS20175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SROS_RS20190	COG0475	glutathione-regulated potassium exporter activity
SROS_RS20210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS20215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SROS_RS20220	COG2345	Transcriptional regulator
SROS_RS20225	COG0702	epimerase
SROS_RS20230	COG2345	Transcriptional regulator
SROS_RS20240	COG0367	asparagine synthase
SROS_RS20245	COG0778	Nitroreductase
SROS_RS20250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SROS_RS20265	COG3629	intracellular signal transduction
SROS_RS20265	COG3903	Transcriptional regulator
SROS_RS20270	COG3547	Transposase (IS116 IS110 IS902 family)
SROS_RS20275	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS20290	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS20295	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS20330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SROS_RS20335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SROS_RS20345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SROS_RS20350	COG0825	malonyl-CoA metabolic process
SROS_RS20350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SROS_RS20355	COG0511	ligase activity, forming carbon-carbon bonds
SROS_RS20360	COG0439	Biotin carboxylase
SROS_RS20375	COG0604	alcohol dehydrogenase
SROS_RS20395	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS20400	COG1404	Belongs to the peptidase S8 family
SROS_RS20405	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SROS_RS20405	COG1672	PFAM Archaeal ATPase
SROS_RS20415	COG2132	Multicopper oxidase
SROS_RS20430	COG3634	alkyl hydroperoxide reductase activity
SROS_RS20435	COG0477	Major facilitator Superfamily
SROS_RS20450	COG0789	Transcriptional regulator
SROS_RS20470	COG4585	Histidine kinase
SROS_RS20475	COG2197	response regulator
SROS_RS20480	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SROS_RS20500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SROS_RS20510	COG4941	Belongs to the sigma-70 factor family
SROS_RS20525	COG0583	DNA-binding transcription factor activity
SROS_RS20530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SROS_RS20535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS20540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS20570	COG3655	Transcriptional regulator
SROS_RS20580	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS20600	COG1846	Transcriptional regulator
SROS_RS20605	COG0697	spore germination
SROS_RS20625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SROS_RS20680	COG1309	transcriptional regulator
SROS_RS20710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS20760	COG1505	serine-type exopeptidase activity
SROS_RS20800	COG3903	Transcriptional regulator
SROS_RS20800	COG3629	intracellular signal transduction
SROS_RS20810	COG4249	Peptidase C14 caspase catalytic subunit p20
SROS_RS20810	COG2319	Wd-40 repeat
SROS_RS20815	COG3835	regulator
SROS_RS20840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SROS_RS20850	COG3629	intracellular signal transduction
SROS_RS20850	COG3629	intracellular signal transduction
SROS_RS20850	COG3903	Transcriptional regulator
SROS_RS20850	COG3903	Transcriptional regulator
SROS_RS20865	COG0017	Asparaginyl-tRNA synthetase
SROS_RS20895	COG1619	proteins homologs of microcin C7 resistance protein MccF
SROS_RS20905	COG1496	oxidoreductase activity
SROS_RS20910	COG1131	(ABC) transporter
SROS_RS20930	COG1404	Belongs to the peptidase S8 family
SROS_RS20945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SROS_RS20950	COG0583	DNA-binding transcription factor activity
SROS_RS20960	COG2226	methyltransferase
SROS_RS20970	COG0640	Transcriptional regulator
SROS_RS20985	COG0587	DNA-directed DNA polymerase activity
SROS_RS20990	COG1136	(ABC) transporter
SROS_RS20990	COG0577	efflux transmembrane transporter activity
SROS_RS20995	COG1136	(ABC) transporter
SROS_RS21030	COG2197	response regulator
SROS_RS21035	COG1720	tRNA m6t6A37 methyltransferase activity
SROS_RS21055	COG4555	ABC transporter
SROS_RS21075	COG2226	methyltransferase
SROS_RS21095	COG2226	methyltransferase
SROS_RS21100	COG3415	Transposase
SROS_RS21100	COG2801	Transposase and inactivated derivatives
SROS_RS21135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SROS_RS21155	COG0277	FAD linked oxidase domain protein
SROS_RS21160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SROS_RS21165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SROS_RS21200	COG0251	oxidation-reduction process
SROS_RS21215	COG1301	dicarboxylic acid transport
SROS_RS21285	COG1136	(ABC) transporter
SROS_RS21295	COG2366	antibiotic biosynthetic process
SROS_RS21305	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS21320	COG3795	YCII-related domain
SROS_RS21325	COG4941	Belongs to the sigma-70 factor family
SROS_RS21335	COG0667	Aldo Keto reductase
SROS_RS21340	COG0583	DNA-binding transcription factor activity
SROS_RS21385	COG4152	abc transporter atp-binding protein
SROS_RS21400	COG1136	(ABC) transporter
SROS_RS21400	COG0577	efflux transmembrane transporter activity
SROS_RS21405	COG1136	(ABC) transporter
SROS_RS21415	COG4585	Histidine kinase
SROS_RS21420	COG2197	response regulator
SROS_RS21470	COG0583	DNA-binding transcription factor activity
SROS_RS21510	COG2223	nitrite transmembrane transporter activity
SROS_RS21535	COG1846	Transcriptional regulator
SROS_RS21540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SROS_RS21545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SROS_RS21560	COG0789	Transcriptional regulator
SROS_RS21575	COG4974	Belongs to the 'phage' integrase family
SROS_RS21605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SROS_RS21620	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SROS_RS21655	COG1846	Transcriptional regulator
SROS_RS21680	COG2197	response regulator
SROS_RS21685	COG4585	Histidine kinase
SROS_RS21695	COG1846	Transcriptional regulator
SROS_RS21730	COG2076	Multidrug Resistance protein
SROS_RS21740	COG1376	ErfK ybiS ycfS ynhG family protein
SROS_RS21770	COG0640	Transcriptional regulator
SROS_RS21775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SROS_RS21790	COG1846	Transcriptional regulator
SROS_RS21815	COG4977	sequence-specific DNA binding
SROS_RS21825	COG0798	PFAM Bile acid sodium symporter
SROS_RS21830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SROS_RS21835	COG0640	Transcriptional regulator
SROS_RS21840	COG2814	Major facilitator Superfamily
SROS_RS21850	COG1309	transcriptional regulator
SROS_RS21855	COG0488	(ABC) transporter
SROS_RS21870	COG0459	protein refolding
SROS_RS21875	COG0667	Aldo Keto reductase
SROS_RS21880	COG2197	response regulator
SROS_RS21885	COG4585	Histidine kinase
SROS_RS21890	COG0657	acetylesterase activity
SROS_RS21895	COG1132	(ABC) transporter
SROS_RS21895	COG2375	cellular response to nickel ion
SROS_RS21900	COG1132	(ABC) transporter
SROS_RS21920	COG1595	DNA-templated transcription, initiation
SROS_RS21930	COG0583	DNA-binding transcription factor activity
SROS_RS21945	COG2267	carboxylic ester hydrolase activity
SROS_RS21965	COG0778	Nitroreductase
SROS_RS21970	COG0583	DNA-binding transcription factor activity
SROS_RS21975	COG0504	CTP synthase activity
SROS_RS22040	COG1309	transcriptional regulator
SROS_RS22060	COG1294	oxidase, subunit
SROS_RS22065	COG1271	oxidase subunit
SROS_RS22080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SROS_RS22110	COG1090	epimerase
SROS_RS22120	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS22160	COG1278	Cold shock
SROS_RS22170	COG0590	tRNA wobble adenosine to inosine editing
SROS_RS22210	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS22215	COG2197	response regulator
SROS_RS22235	COG4585	Histidine kinase
SROS_RS22240	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS22245	COG1309	transcriptional regulator
SROS_RS22270	COG1695	Transcriptional regulator
SROS_RS22290	COG0154	amidase activity
SROS_RS22295	COG0583	DNA-binding transcription factor activity
SROS_RS22300	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SROS_RS22310	COG0765	amino acid transport
SROS_RS22320	COG2197	response regulator
SROS_RS22325	COG0596	Alpha beta hydrolase
SROS_RS22330	COG2197	response regulator
SROS_RS22335	COG1404	Belongs to the peptidase S8 family
SROS_RS22340	COG0583	DNA-binding transcription factor activity
SROS_RS22345	COG1271	oxidase subunit
SROS_RS22375	COG1063	alcohol dehydrogenase
SROS_RS22400	COG2319	Wd-40 repeat
SROS_RS22415	COG0596	Alpha beta hydrolase
SROS_RS22485	COG0655	NAD(P)H dehydrogenase (quinone) activity
SROS_RS22575	COG1695	Transcriptional regulator
SROS_RS22660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SROS_RS22685	COG2197	response regulator
SROS_RS22710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SROS_RS22730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SROS_RS22770	COG0577	efflux transmembrane transporter activity
SROS_RS22770	COG1136	(ABC) transporter
SROS_RS22780	COG3547	Transposase (IS116 IS110 IS902 family)
SROS_RS22790	COG3547	Transposase (IS116 IS110 IS902 family)
SROS_RS22800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SROS_RS22905	COG1335	isochorismatase
SROS_RS22910	COG2267	carboxylic ester hydrolase activity
SROS_RS22960	COG3293	Transposase
SROS_RS22995	COG2814	Major facilitator Superfamily
SROS_RS23030	COG2197	response regulator
SROS_RS23035	COG3850	Histidine kinase
SROS_RS23045	COG1131	(ABC) transporter
SROS_RS23060	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS23085	COG2205	protein histidine kinase activity
SROS_RS23090	COG0745	RESPONSE REGULATOR receiver
SROS_RS23185	COG1484	DNA-dependent DNA replication
SROS_RS23255	COG4585	Histidine kinase
SROS_RS23300	COG0589	response to stress
SROS_RS23335	COG0517	IMP dehydrogenase activity
SROS_RS23335	COG0516	GMP reductase activity
SROS_RS23360	COG2132	Multicopper oxidase
SROS_RS23375	COG0589	response to stress
SROS_RS23415	COG0589	response to stress
SROS_RS23425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SROS_RS23445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SROS_RS23490	COG2186	Transcriptional regulator
SROS_RS23495	COG0402	S-adenosylhomocysteine deaminase activity
SROS_RS23500	COG4166	transmembrane transport
SROS_RS23510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS23520	COG4608	Belongs to the ABC transporter superfamily
SROS_RS23525	COG0402	S-adenosylhomocysteine deaminase activity
SROS_RS23540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SROS_RS23545	COG4266	Belongs to the allantoicase family
SROS_RS23550	COG0590	tRNA wobble adenosine to inosine editing
SROS_RS23565	COG0583	DNA-binding transcription factor activity
SROS_RS23585	COG1131	(ABC) transporter
SROS_RS23590	COG1725	Transcriptional regulator
SROS_RS23605	COG2132	Multicopper oxidase
SROS_RS23630	COG1595	DNA-templated transcription, initiation
SROS_RS23640	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS23655	COG0395	ABC-type sugar transport system, permease component
SROS_RS23660	COG1175	transmembrane transport
SROS_RS23665	COG1653	transport
SROS_RS23690	COG1609	Transcriptional regulator
SROS_RS23700	COG1175	transmembrane transport
SROS_RS23705	COG0395	ABC-type sugar transport system, permease component
SROS_RS23715	COG3250	beta-galactosidase activity
SROS_RS23725	COG1672	PFAM Archaeal ATPase
SROS_RS23725	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SROS_RS23735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS23760	COG1228	amidohydrolase
SROS_RS23770	COG2132	Multicopper oxidase
SROS_RS23775	COG2272	Belongs to the type-B carboxylesterase lipase family
SROS_RS23780	COG0789	Transcriptional regulator
SROS_RS23800	COG0745	RESPONSE REGULATOR receiver
SROS_RS23805	COG2205	protein histidine kinase activity
SROS_RS23830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SROS_RS23895	COG0488	(ABC) transporter
SROS_RS23900	COG0574	Belongs to the PEP-utilizing enzyme family
SROS_RS23900	COG3848	Pyruvate phosphate dikinase
SROS_RS23940	COG2197	response regulator
SROS_RS23950	COG2084	Dehydrogenase
SROS_RS23965	COG0133	tryptophan synthase activity
SROS_RS23970	COG0159	tryptophan synthase activity
SROS_RS23975	COG2188	Transcriptional regulator
SROS_RS24015	COG0640	Transcriptional regulator
SROS_RS24020	COG0492	ferredoxin-NADP+ reductase activity
SROS_RS24025	COG2234	aminopeptidase activity
SROS_RS24030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SROS_RS24040	COG1104	cysteine desulfurase activity
SROS_RS24100	COG0395	ABC-type sugar transport system, permease component
SROS_RS24115	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SROS_RS24125	COG1940	carbohydrate kinase activity
SROS_RS24140	COG1482	cell wall glycoprotein biosynthetic process
SROS_RS24170	COG1609	Transcriptional regulator
SROS_RS24185	COG0395	ABC-type sugar transport system, permease component
SROS_RS24210	COG1309	transcriptional regulator
SROS_RS24300	COG1335	isochorismatase
SROS_RS24305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SROS_RS24325	COG1846	Transcriptional regulator
SROS_RS24350	COG0583	DNA-binding transcription factor activity
SROS_RS24360	COG1250	3-hydroxyacyl-CoA dehydrogenase
SROS_RS24370	COG2423	ornithine cyclodeaminase activity
SROS_RS24375	COG0154	amidase activity
SROS_RS24385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SROS_RS24390	COG3246	L-lysine catabolic process to acetate
SROS_RS24395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SROS_RS24410	COG0477	Major facilitator Superfamily
SROS_RS24435	COG0789	Transcriptional regulator
SROS_RS24450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS24455	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SROS_RS24470	COG1228	amidohydrolase
SROS_RS24510	COG1733	regulation of RNA biosynthetic process
SROS_RS24515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SROS_RS24545	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS24565	COG1309	transcriptional regulator
SROS_RS24570	COG2318	DinB family
SROS_RS24575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SROS_RS24585	COG4941	Belongs to the sigma-70 factor family
SROS_RS24600	COG1309	transcriptional regulator
SROS_RS24625	COG0596	Alpha beta hydrolase
SROS_RS24630	COG0596	Alpha beta hydrolase
SROS_RS24635	COG0596	Alpha beta hydrolase
SROS_RS24645	COG2207	Transcriptional regulator
SROS_RS24675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS24680	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS24685	COG1120	ATPase activity
SROS_RS24700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SROS_RS24740	COG0583	DNA-binding transcription factor activity
SROS_RS24745	COG0697	spore germination
SROS_RS24770	COG1252	NADH dehydrogenase
SROS_RS24775	COG1595	DNA-templated transcription, initiation
SROS_RS24830	COG0574	Belongs to the PEP-utilizing enzyme family
SROS_RS24830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SROS_RS24860	COG2080	2 iron, 2 sulfur cluster binding
SROS_RS24865	COG2010	Cytochrome c
SROS_RS24865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SROS_RS24885	COG0142	geranyltranstransferase activity
SROS_RS24935	COG1595	DNA-templated transcription, initiation
SROS_RS24960	COG1309	transcriptional regulator
SROS_RS24965	COG1309	transcriptional regulator
SROS_RS24985	COG1819	glycosyl
SROS_RS24990	COG3973	AAA domain
SROS_RS25015	COG0604	alcohol dehydrogenase
SROS_RS25015	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS25015	COG3321	synthase
SROS_RS25020	COG0702	epimerase
SROS_RS25030	COG1104	cysteine desulfurase activity
SROS_RS25040	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS25060	COG1864	DNA RNA non-specific endonuclease
SROS_RS25060	COG3591	Belongs to the peptidase S1B family
SROS_RS25065	COG2267	carboxylic ester hydrolase activity
SROS_RS25075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SROS_RS25090	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS25105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SROS_RS25120	COG0730	response to heat
SROS_RS25125	COG0730	response to heat
SROS_RS25135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SROS_RS25145	COG0483	inositol monophosphate 1-phosphatase activity
SROS_RS25160	COG0596	Alpha beta hydrolase
SROS_RS25165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS25180	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS25185	COG1309	transcriptional regulator
SROS_RS25205	COG0667	Aldo Keto reductase
SROS_RS25215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SROS_RS25220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS25225	COG0662	Cupin 2, conserved barrel domain protein
SROS_RS25245	COG2124	cytochrome p450
SROS_RS25250	COG2409	Drug exporters of the RND superfamily
SROS_RS25285	COG2318	DinB family
SROS_RS25310	COG0477	Major facilitator Superfamily
SROS_RS25330	COG0367	asparagine synthase
SROS_RS25335	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS25345	COG3903	Transcriptional regulator
SROS_RS25345	COG3629	intracellular signal transduction
SROS_RS25350	COG0596	Alpha beta hydrolase
SROS_RS25355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SROS_RS25390	COG0601	transmembrane transport
SROS_RS25395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS25420	COG4948	Mandelate Racemase Muconate Lactonizing
SROS_RS25425	COG2362	D-Aminopeptidase
SROS_RS25435	COG1309	transcriptional regulator
SROS_RS25450	COG0667	Aldo Keto reductase
SROS_RS25460	COG2267	carboxylic ester hydrolase activity
SROS_RS25490	COG2814	Major facilitator Superfamily
SROS_RS25495	COG0697	spore germination
SROS_RS25500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SROS_RS25520	COG5297	Belongs to the glycosyl hydrolase family 6
SROS_RS25520	COG4733	cellulase activity
SROS_RS25535	COG1917	Cupin 2, conserved barrel domain protein
SROS_RS25545	COG2267	carboxylic ester hydrolase activity
SROS_RS25560	COG2197	response regulator
SROS_RS25580	COG0395	ABC-type sugar transport system, permease component
SROS_RS25585	COG1175	transmembrane transport
SROS_RS25625	COG0586	Pfam SNARE associated Golgi protein
SROS_RS25645	COG2813	Specifically methylates the guanine in position
SROS_RS25655	COG0702	epimerase
SROS_RS25695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SROS_RS25725	COG1690	Belongs to the RtcB family
SROS_RS25750	COG0477	Major facilitator Superfamily
SROS_RS25755	COG1846	Transcriptional regulator
SROS_RS25760	COG3655	Transcriptional regulator
SROS_RS25780	COG3903	Transcriptional regulator
SROS_RS25780	COG3629	intracellular signal transduction
SROS_RS25810	COG0445	tRNA wobble uridine modification
SROS_RS25835	COG1733	regulation of RNA biosynthetic process
SROS_RS25880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS25900	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS25905	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
SROS_RS25915	COG0439	Biotin carboxylase
SROS_RS25945	COG0488	(ABC) transporter
SROS_RS25950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SROS_RS25960	COG3559	Exporter of polyketide antibiotics
SROS_RS25965	COG1131	(ABC) transporter
SROS_RS25990	COG0702	epimerase
SROS_RS26005	COG2378	regulation of single-species biofilm formation
SROS_RS26015	COG0738	Major facilitator superfamily
SROS_RS26025	COG4585	Histidine kinase
SROS_RS26045	COG0366	Alpha amylase catalytic
SROS_RS26050	COG0395	ABC-type sugar transport system, permease component
SROS_RS26055	COG1175	transmembrane transport
SROS_RS26070	COG0446	pyridine nucleotide-disulphide oxidoreductase
SROS_RS26105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SROS_RS26150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SROS_RS26150	COG0072	phenylalanine-tRNA ligase activity
SROS_RS26170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SROS_RS26210	COG1140	nitrate reductase beta subunit
SROS_RS26230	COG2205	protein histidine kinase activity
SROS_RS26235	COG0745	RESPONSE REGULATOR receiver
SROS_RS26245	COG0702	epimerase
SROS_RS26250	COG2890	protein-(glutamine-N5) methyltransferase activity
SROS_RS26255	COG2814	Major facilitator Superfamily
SROS_RS26270	COG1268	BioY protein
SROS_RS26275	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS26280	COG0183	Belongs to the thiolase family
SROS_RS26285	COG1122	ATPase activity
SROS_RS26290	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SROS_RS26295	COG4941	Belongs to the sigma-70 factor family
SROS_RS26305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SROS_RS26310	COG1993	acr, cog1993
SROS_RS26315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SROS_RS26320	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS26370	COG1309	transcriptional regulator
SROS_RS26380	COG3835	regulator
SROS_RS26390	COG1357	PFAM Pentapeptide repeats (8 copies)
SROS_RS26405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS26420	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS26425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SROS_RS26440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SROS_RS26480	COG0753	catalase activity
SROS_RS26490	COG2197	response regulator
SROS_RS26500	COG0714	Associated with various cellular activities
SROS_RS26510	COG2304	oxidoreductase activity
SROS_RS26515	COG2813	Specifically methylates the guanine in position
SROS_RS26520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SROS_RS26560	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SROS_RS26595	COG1064	alcohol dehydrogenase
SROS_RS26615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SROS_RS26635	COG1653	transport
SROS_RS26640	COG1175	transmembrane transport
SROS_RS26645	COG0395	ABC-type sugar transport system, permease component
SROS_RS26650	COG1940	carbohydrate kinase activity
SROS_RS26665	COG1649	PFAM Uncharacterised BCR, COG1649
SROS_RS26680	COG1846	Transcriptional regulator
SROS_RS26725	COG3795	YCII-related domain
SROS_RS26730	COG4941	Belongs to the sigma-70 factor family
SROS_RS26755	COG0583	DNA-binding transcription factor activity
SROS_RS26790	COG2188	Transcriptional regulator
SROS_RS26795	COG0673	inositol 2-dehydrogenase activity
SROS_RS26805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SROS_RS26815	COG3718	enzyme involved in inositol metabolism
SROS_RS26820	COG3962	Belongs to the TPP enzyme family
SROS_RS26835	COG1178	ABC-type Fe3 transport system permease component
SROS_RS26850	COG0483	inositol monophosphate 1-phosphatase activity
SROS_RS26855	COG0561	phosphatase activity
SROS_RS26865	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SROS_RS26870	COG1126	abc transporter atp-binding protein
SROS_RS26875	COG0765	amino acid transport
SROS_RS26890	COG1881	PFAM PEBP family protein
SROS_RS26900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SROS_RS26925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS26975	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SROS_RS26995	COG0242	peptide deformylase activity
SROS_RS27005	COG1231	oxidoreductase activity
SROS_RS27020	COG3226	Transcriptional regulator
SROS_RS27025	COG0477	Major facilitator Superfamily
SROS_RS27040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS27050	COG2814	Major facilitator Superfamily
SROS_RS27075	COG1131	(ABC) transporter
SROS_RS27080	COG4585	Histidine kinase
SROS_RS27085	COG2197	response regulator
SROS_RS27095	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SROS_RS27110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SROS_RS27115	COG1733	regulation of RNA biosynthetic process
SROS_RS27120	COG0702	epimerase
SROS_RS27150	COG0514	ATP-dependent DNA helicase (RecQ)
SROS_RS27175	COG1609	Transcriptional regulator
SROS_RS27215	COG2814	Major facilitator Superfamily
SROS_RS27235	COG1131	(ABC) transporter
SROS_RS27240	COG2205	protein histidine kinase activity
SROS_RS27245	COG0745	RESPONSE REGULATOR receiver
SROS_RS27265	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SROS_RS27295	COG0739	heme binding
SROS_RS27380	COG1649	PFAM Uncharacterised BCR, COG1649
SROS_RS27385	COG1472	Belongs to the glycosyl hydrolase 3 family
SROS_RS27410	COG1522	sequence-specific DNA binding
SROS_RS27420	COG0667	Aldo Keto reductase
SROS_RS27435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SROS_RS27440	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SROS_RS27445	COG3876	Protein conserved in bacteria
SROS_RS27455	COG4608	Belongs to the ABC transporter superfamily
SROS_RS27460	COG0444	Belongs to the ABC transporter superfamily
SROS_RS27465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS27495	COG4948	Mandelate Racemase Muconate Lactonizing
SROS_RS27510	COG0444	Belongs to the ABC transporter superfamily
SROS_RS27550	COG0326	Molecular chaperone. Has ATPase activity
SROS_RS27605	COG2235	arginine
SROS_RS27635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SROS_RS27640	COG1063	alcohol dehydrogenase
SROS_RS27645	COG1653	transport
SROS_RS27650	COG1175	transmembrane transport
SROS_RS27660	COG4948	Mandelate Racemase Muconate Lactonizing
SROS_RS27670	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS27685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SROS_RS27690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SROS_RS27700	COG1960	acyl-CoA dehydrogenase activity
SROS_RS27725	COG2130	NADP-dependent
SROS_RS27750	COG0346	lactoylglutathione lyase activity
SROS_RS27815	COG0747	negative chemotaxis
SROS_RS27820	COG0601	transmembrane transport
SROS_RS27825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS27830	COG0444	Belongs to the ABC transporter superfamily
SROS_RS27835	COG4608	Belongs to the ABC transporter superfamily
SROS_RS27850	COG1902	pentaerythritol trinitrate reductase activity
SROS_RS27860	COG0477	Major facilitator Superfamily
SROS_RS27870	COG3903	Transcriptional regulator
SROS_RS27870	COG3629	intracellular signal transduction
SROS_RS27890	COG5564	TIM-barrel signal transduction protein
SROS_RS27905	COG3226	Transcriptional regulator
SROS_RS27930	COG0728	peptidoglycan biosynthetic process
SROS_RS27960	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS27965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS27985	COG5640	endopeptidase activity
SROS_RS27995	COG0477	Major facilitator Superfamily
SROS_RS28010	COG2132	Multicopper oxidase
SROS_RS28030	COG3030	protein affecting phage T7 exclusion by the F plasmid
SROS_RS28035	COG0463	Glycosyl transferase, family 2
SROS_RS28040	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SROS_RS28045	COG3973	AAA domain
SROS_RS28045	COG3973	AAA domain
SROS_RS28065	COG0395	ABC-type sugar transport system, permease component
SROS_RS28070	COG1486	melibiose metabolic process
SROS_RS28080	COG4941	Belongs to the sigma-70 factor family
SROS_RS28085	COG3795	YCII-related domain
SROS_RS28120	COG3293	Transposase
SROS_RS28135	COG0659	secondary active sulfate transmembrane transporter activity
SROS_RS28160	COG1522	sequence-specific DNA binding
SROS_RS28165	COG4251	negative regulation of phosphorylation
SROS_RS28170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SROS_RS28175	COG1902	pentaerythritol trinitrate reductase activity
SROS_RS28190	COG1960	acyl-CoA dehydrogenase activity
SROS_RS28205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SROS_RS28225	COG0805	protein transport
SROS_RS28275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SROS_RS28285	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SROS_RS28290	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SROS_RS28305	COG2011	ABC-type metal ion transport system permease component
SROS_RS28310	COG3842	ATPase activity
SROS_RS28315	COG0613	PHP domain protein
SROS_RS28320	COG0673	inositol 2-dehydrogenase activity
SROS_RS28325	COG0383	alpha-mannosidase activity
SROS_RS28340	COG0515	serine threonine protein kinase
SROS_RS28345	COG0515	serine threonine protein kinase
SROS_RS28350	COG1797	cobyrinic acid a,c-diamide synthase activity
SROS_RS28380	COG4122	O-methyltransferase activity
SROS_RS28390	COG1222	aaa ATPase
SROS_RS28410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SROS_RS28415	COG3226	Transcriptional regulator
SROS_RS28425	COG0475	glutathione-regulated potassium exporter activity
SROS_RS28445	COG0517	IMP dehydrogenase activity
SROS_RS28445	COG1994	Peptidase M50
SROS_RS28455	COG4585	Histidine kinase
SROS_RS28460	COG2197	response regulator
SROS_RS28485	COG4608	Belongs to the ABC transporter superfamily
SROS_RS28490	COG0444	Belongs to the ABC transporter superfamily
SROS_RS28500	COG4166	transmembrane transport
SROS_RS28520	COG0646	methionine synthase
SROS_RS28520	COG1410	methionine synthase
SROS_RS28555	COG2146	nitrite reductase [NAD(P)H] activity
SROS_RS28555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SROS_RS28560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SROS_RS28565	COG0243	molybdopterin cofactor binding
SROS_RS28570	COG2223	nitrite transmembrane transporter activity
SROS_RS28575	COG0242	peptide deformylase activity
SROS_RS28580	COG1278	Cold shock
SROS_RS28585	COG0215	cysteine-tRNA ligase activity
SROS_RS28610	COG0667	Aldo Keto reductase
SROS_RS28620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SROS_RS28625	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS28645	COG3360	Dodecin
SROS_RS28660	COG0746	molybdenum cofactor guanylyltransferase activity
SROS_RS28665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SROS_RS28670	COG1690	Belongs to the RtcB family
SROS_RS28705	COG3104	oligopeptide transport
SROS_RS28710	COG2860	membrane
SROS_RS28715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS28720	COG2364	Membrane
SROS_RS28725	COG3387	PFAM Glycoside hydrolase 15-related
SROS_RS28735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SROS_RS28765	COG1619	proteins homologs of microcin C7 resistance protein MccF
SROS_RS28775	COG1132	(ABC) transporter
SROS_RS28790	COG0488	(ABC) transporter
SROS_RS28815	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SROS_RS28820	COG0140	phosphoribosyl-ATP diphosphatase activity
SROS_RS28830	COG0513	Belongs to the DEAD box helicase family
SROS_RS28835	COG2151	metal-sulfur cluster biosynthetic enzyme
SROS_RS28840	COG0822	iron-sulfur transferase activity
SROS_RS28845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SROS_RS28850	COG0396	ATPase activity
SROS_RS28875	COG2814	Major facilitator Superfamily
SROS_RS28885	COG1131	(ABC) transporter
SROS_RS28900	COG5006	permease, DMT superfamily
SROS_RS28905	COG1802	Transcriptional regulator
SROS_RS28945	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS28950	COG3938	Belongs to the proline racemase family
SROS_RS28955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SROS_RS28970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SROS_RS28980	COG2949	membrane
SROS_RS28990	COG0109	protoheme IX farnesyltransferase activity
SROS_RS29000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SROS_RS29005	COG0166	Belongs to the GPI family
SROS_RS29020	COG0363	glucosamine-6-phosphate deaminase activity
SROS_RS29025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SROS_RS29030	COG0542	response to heat
SROS_RS29040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SROS_RS29065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SROS_RS29085	COG2197	response regulator
SROS_RS29090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SROS_RS29100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SROS_RS29105	COG0149	triose-phosphate isomerase activity
SROS_RS29110	COG0126	phosphoglycerate kinase activity
SROS_RS29115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SROS_RS29120	COG1481	regulation of sporulation
SROS_RS29130	COG1660	Displays ATPase and GTPase activities
SROS_RS29135	COG0322	excinuclease ABC activity
SROS_RS29150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SROS_RS29160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SROS_RS29170	COG0688	phosphatidylethanolamine metabolic process
SROS_RS29180	COG0297	glycogen (starch) synthase activity
SROS_RS29205	COG0497	DNA recombination
SROS_RS29210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SROS_RS29230	COG0647	UMP catabolic process
SROS_RS29275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SROS_RS29280	COG2094	Belongs to the DNA glycosylase MPG family
SROS_RS29285	COG0165	Argininosuccinate lyase
SROS_RS29290	COG0137	argininosuccinate synthase activity
SROS_RS29295	COG1438	arginine binding
SROS_RS29300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SROS_RS29305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SROS_RS29310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SROS_RS29315	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SROS_RS29320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SROS_RS29325	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS29340	COG0072	phenylalanine-tRNA ligase activity
SROS_RS29340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SROS_RS29345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SROS_RS29350	COG5002	protein histidine kinase activity
SROS_RS29355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SROS_RS29360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SROS_RS29365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SROS_RS29370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SROS_RS29385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SROS_RS29395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SROS_RS29400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SROS_RS29430	COG2124	cytochrome p450
SROS_RS29435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SROS_RS29440	COG0124	histidyl-tRNA synthetase
SROS_RS29450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SROS_RS29455	COG1196	nuclear chromosome segregation
SROS_RS29460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SROS_RS29465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SROS_RS29470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SROS_RS29475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SROS_RS29485	COG2255	four-way junction helicase activity
SROS_RS29490	COG0632	four-way junction helicase activity
SROS_RS29495	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SROS_RS29510	COG0217	transcriptional regulatory protein
SROS_RS29515	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SROS_RS29520	COG2814	Major facilitator Superfamily
SROS_RS29530	COG3540	Alkaline phosphatase
SROS_RS29535	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SROS_RS29550	COG0438	transferase activity, transferring glycosyl groups
SROS_RS29555	COG1560	Kdo2-lipid A biosynthetic process
SROS_RS29560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SROS_RS29570	COG1649	PFAM Uncharacterised BCR, COG1649
SROS_RS29590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SROS_RS29615	COG2197	response regulator
SROS_RS29625	COG1960	acyl-CoA dehydrogenase activity
SROS_RS29645	COG1472	Belongs to the glycosyl hydrolase 3 family
SROS_RS29650	COG0569	domain protein
SROS_RS29695	COG2986	histidine ammonia-lyase
SROS_RS29730	COG1733	regulation of RNA biosynthetic process
SROS_RS29755	COG2197	response regulator
SROS_RS29760	COG4585	Histidine kinase
SROS_RS29765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SROS_RS29785	COG0831	urea catabolic process
SROS_RS29785	COG0832	Belongs to the urease beta subunit family
SROS_RS29790	COG0804	urea catabolic process
SROS_RS29795	COG2957	Belongs to the agmatine deiminase family
SROS_RS29805	COG1846	Transcriptional regulator
SROS_RS29820	COG1609	Transcriptional regulator
SROS_RS29825	COG0747	negative chemotaxis
SROS_RS29835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS29840	COG0444	Belongs to the ABC transporter superfamily
SROS_RS29845	COG4608	Belongs to the ABC transporter superfamily
SROS_RS29850	COG0154	amidase activity
SROS_RS29875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SROS_RS29880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SROS_RS29900	COG1397	ADP-ribosylglycohydrolase
SROS_RS29915	COG1175	transmembrane transport
SROS_RS29935	COG2197	response regulator
SROS_RS29940	COG4585	Histidine kinase
SROS_RS29970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SROS_RS30005	COG0644	oxidoreductase
SROS_RS30015	COG2197	response regulator
SROS_RS30020	COG4585	Histidine kinase
SROS_RS30025	COG2409	Drug exporters of the RND superfamily
SROS_RS30035	COG2271	Major facilitator Superfamily
SROS_RS30045	COG2160	L-arabinose isomerase activity
SROS_RS30060	COG1172	Belongs to the binding-protein-dependent transport system permease family
SROS_RS30065	COG1172	Belongs to the binding-protein-dependent transport system permease family
SROS_RS30075	COG1879	ABC-type sugar transport system periplasmic component
SROS_RS30080	COG1609	Transcriptional regulator
SROS_RS30130	COG2337	Toxic component of a toxin-antitoxin (TA) module
SROS_RS30140	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SROS_RS30140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SROS_RS30175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SROS_RS30185	COG3483	tryptophan 2,3-dioxygenase activity
SROS_RS30190	COG1522	sequence-specific DNA binding
SROS_RS30205	COG1309	transcriptional regulator
SROS_RS30240	COG0297	glycogen (starch) synthase activity
SROS_RS30245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SROS_RS30265	COG0668	transmembrane transport
SROS_RS30270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SROS_RS30275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SROS_RS30275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SROS_RS30290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SROS_RS30340	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SROS_RS30365	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS30370	COG0823	Involved in the tonB-independent uptake of proteins
SROS_RS30370	COG1506	peptidase
SROS_RS30370	COG4946	Tricorn protease homolog
SROS_RS30380	COG0667	Aldo Keto reductase
SROS_RS30390	COG0583	DNA-binding transcription factor activity
SROS_RS30395	COG0667	Aldo Keto reductase
SROS_RS30410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SROS_RS30415	COG1940	carbohydrate kinase activity
SROS_RS30420	COG1126	abc transporter atp-binding protein
SROS_RS30425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SROS_RS30430	COG0765	amino acid transport
SROS_RS30435	COG0765	amino acid transport
SROS_RS30445	COG3142	Participates in the control of copper homeostasis
SROS_RS30455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SROS_RS30455	COG1796	DNA polymerase
SROS_RS30485	COG2197	response regulator
SROS_RS30495	COG1309	transcriptional regulator
SROS_RS30515	COG0667	Aldo Keto reductase
SROS_RS30520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SROS_RS30550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SROS_RS30560	COG3279	Response regulator of the LytR AlgR family
SROS_RS30570	COG3275	phosphorelay sensor kinase activity
SROS_RS30600	COG2301	Belongs to the HpcH HpaI aldolase family
SROS_RS30605	COG1960	acyl-CoA dehydrogenase activity
SROS_RS30610	COG2030	dehydratase
SROS_RS30615	COG2186	Transcriptional regulator
SROS_RS30665	COG1597	lipid kinase activity
SROS_RS30670	COG0675	Transposase, IS605 OrfB family
SROS_RS30685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SROS_RS30690	COG0277	FAD linked oxidase domain protein
SROS_RS30700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SROS_RS30710	COG1024	Enoyl-CoA hydratase
SROS_RS30760	COG4221	oxidoreductase activity
SROS_RS30785	COG0583	DNA-binding transcription factor activity
SROS_RS30865	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SROS_RS30875	COG2205	protein histidine kinase activity
SROS_RS30880	COG0745	RESPONSE REGULATOR receiver
SROS_RS30900	COG2855	membrane
SROS_RS30905	COG2313	pseudouridylate synthase activity
SROS_RS30940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS30945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SROS_RS30950	COG1960	acyl-CoA dehydrogenase activity
SROS_RS30965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SROS_RS31000	COG0022	dehydrogenase e1 component
SROS_RS31005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SROS_RS31005	COG2124	cytochrome p450
SROS_RS31040	COG0598	Magnesium transport protein CorA
SROS_RS31065	COG0515	serine threonine protein kinase
SROS_RS31070	COG1132	(ABC) transporter
SROS_RS31075	COG1132	(ABC) transporter
SROS_RS31080	COG1505	serine-type exopeptidase activity
SROS_RS31085	COG2197	response regulator
SROS_RS31135	COG1309	transcriptional regulator
SROS_RS31140	COG0419	ATPase involved in DNA repair
SROS_RS31145	COG0420	3'-5' exonuclease activity
SROS_RS31160	COG1024	Enoyl-CoA hydratase
SROS_RS31195	COG4948	Mandelate Racemase Muconate Lactonizing
SROS_RS31210	COG0477	Major facilitator Superfamily
SROS_RS31235	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SROS_RS31245	COG0714	Associated with various cellular activities
SROS_RS31265	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS31280	COG2172	sigma factor antagonist activity
SROS_RS31295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SROS_RS31305	COG1472	Belongs to the glycosyl hydrolase 3 family
SROS_RS31315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SROS_RS31350	COG0463	Glycosyl transferase, family 2
SROS_RS31360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SROS_RS31380	COG0438	transferase activity, transferring glycosyl groups
SROS_RS31385	COG0367	asparagine synthase
SROS_RS31415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SROS_RS31420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SROS_RS31425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SROS_RS31430	COG0489	protein tyrosine kinase activity
SROS_RS31455	COG0300	oxidoreductase activity
SROS_RS31465	COG3842	ATPase activity
SROS_RS31470	COG1609	Transcriptional regulator
SROS_RS31475	COG0386	Belongs to the glutathione peroxidase family
SROS_RS31525	COG0025	NhaP-type Na H and K H
SROS_RS31545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SROS_RS31550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SROS_RS31555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SROS_RS31560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SROS_RS31565	COG1846	Transcriptional regulator
SROS_RS31570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SROS_RS31595	COG0549	Belongs to the carbamate kinase family
SROS_RS31625	COG0395	ABC-type sugar transport system, permease component
SROS_RS31630	COG1175	transmembrane transport
SROS_RS31635	COG3250	beta-galactosidase activity
SROS_RS31640	COG1609	Transcriptional regulator
SROS_RS31655	COG3251	PFAM MbtH domain protein
SROS_RS31665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SROS_RS31680	COG2409	Drug exporters of the RND superfamily
SROS_RS31690	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS31710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SROS_RS31715	COG0450	alkyl hydroperoxide reductase
SROS_RS31805	COG1653	transport
SROS_RS31815	COG0395	ABC-type sugar transport system, permease component
SROS_RS31825	COG1609	Transcriptional regulator
SROS_RS31840	COG1725	Transcriptional regulator
SROS_RS31845	COG1131	(ABC) transporter
SROS_RS31870	COG1435	thymidine kinase activity
SROS_RS31890	COG1960	acyl-CoA dehydrogenase activity
SROS_RS31905	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS31970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SROS_RS31990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SROS_RS31995	COG1335	isochorismatase
SROS_RS32000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS32005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SROS_RS32040	COG2079	MmgE PrpD family protein
SROS_RS32050	COG1414	Transcriptional regulator
SROS_RS32070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SROS_RS32125	COG2212	antiporter activity
SROS_RS32135	COG0651	ATP synthesis coupled electron transport
SROS_RS32140	COG1006	Multisubunit Na H antiporter MnhC subunit
SROS_RS32145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SROS_RS32145	COG2111	Na H antiporter
SROS_RS32180	COG1271	oxidase subunit
SROS_RS32185	COG1294	oxidase, subunit
SROS_RS32195	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
SROS_RS32220	COG2233	PERMEase
SROS_RS32225	COG2501	S4 domain
SROS_RS32240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SROS_RS32245	COG1304	FMN binding
SROS_RS32255	COG2814	Major facilitator Superfamily
SROS_RS32260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SROS_RS32275	COG0277	FAD linked oxidase domain protein
SROS_RS32310	COG1162	GTPase activity
SROS_RS32315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SROS_RS32325	COG3304	Inner membrane component domain
SROS_RS32335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SROS_RS32345	COG0175	sulfate reduction
SROS_RS32375	COG1960	acyl-CoA dehydrogenase activity
SROS_RS32405	COG1793	dna ligase
SROS_RS32415	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS32420	COG1960	acyl-CoA dehydrogenase activity
SROS_RS32430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SROS_RS32440	COG3253	May function as heme-dependent peroxidase
SROS_RS32445	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SROS_RS32455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SROS_RS32470	COG0673	inositol 2-dehydrogenase activity
SROS_RS32490	COG1609	Transcriptional regulator
SROS_RS32495	COG0183	Belongs to the thiolase family
SROS_RS32500	COG1024	Enoyl-CoA hydratase
SROS_RS32500	COG1250	3-hydroxyacyl-CoA dehydrogenase
SROS_RS32510	COG0531	amino acid
SROS_RS32520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SROS_RS32545	COG4214	carbohydrate transport
SROS_RS32555	COG4213	ABC transporter substrate-binding protein
SROS_RS32560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SROS_RS32590	COG3663	DNA glycosylase
SROS_RS32595	COG0477	Major facilitator Superfamily
SROS_RS32605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SROS_RS32625	COG0542	response to heat
SROS_RS32630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SROS_RS32635	COG0531	amino acid
SROS_RS32640	COG0569	domain protein
SROS_RS32665	COG0756	dUTP diphosphatase activity
SROS_RS32680	COG0525	valine-tRNA ligase activity
SROS_RS32690	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SROS_RS32705	COG2205	protein histidine kinase activity
SROS_RS32710	COG0745	RESPONSE REGULATOR receiver
SROS_RS32720	COG4946	Tricorn protease homolog
SROS_RS32720	COG1506	peptidase
SROS_RS32720	COG0823	Involved in the tonB-independent uptake of proteins
SROS_RS32725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SROS_RS32775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SROS_RS32810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SROS_RS32820	COG1366	Belongs to the anti-sigma-factor antagonist family
SROS_RS32850	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS32860	COG2205	protein histidine kinase activity
SROS_RS32865	COG0745	RESPONSE REGULATOR receiver
SROS_RS32870	COG2318	DinB family
SROS_RS32910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SROS_RS32935	COG4948	Mandelate Racemase Muconate Lactonizing
SROS_RS32945	COG1960	acyl-CoA dehydrogenase activity
SROS_RS32950	COG1960	acyl-CoA dehydrogenase activity
SROS_RS32955	COG2205	protein histidine kinase activity
SROS_RS32980	COG1609	Transcriptional regulator
SROS_RS33010	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS33030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SROS_RS33040	COG0508	dehydrogenase complex catalyzes the overall conversion of
SROS_RS33130	COG1280	lysine exporter protein (LysE YggA)
SROS_RS33140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SROS_RS33155	COG0673	inositol 2-dehydrogenase activity
SROS_RS33185	COG1132	(ABC) transporter
SROS_RS33250	COG1643	Atp-dependent helicase
SROS_RS33255	COG5297	Belongs to the glycosyl hydrolase family 6
SROS_RS33285	COG2130	NADP-dependent
SROS_RS33310	COG0488	(ABC) transporter
SROS_RS33330	COG1960	acyl-CoA dehydrogenase activity
SROS_RS33340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SROS_RS33350	COG1253	flavin adenine dinucleotide binding
SROS_RS33365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SROS_RS33375	COG2409	Drug exporters of the RND superfamily
SROS_RS33380	COG3866	Pectate lyase
SROS_RS33395	COG3629	intracellular signal transduction
SROS_RS33395	COG3903	Transcriptional regulator
SROS_RS33420	COG0366	Alpha amylase catalytic
SROS_RS33425	COG0514	ATP-dependent DNA helicase (RecQ)
SROS_RS33470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SROS_RS33495	COG1846	Transcriptional regulator
SROS_RS33540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SROS_RS33550	COG0583	DNA-binding transcription factor activity
SROS_RS33575	COG0477	Major facilitator Superfamily
SROS_RS33590	COG0596	Alpha beta hydrolase
SROS_RS33595	COG0477	Major facilitator Superfamily
SROS_RS33610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SROS_RS33625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SROS_RS33630	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS33655	COG1960	acyl-CoA dehydrogenase activity
SROS_RS33675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SROS_RS33690	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SROS_RS33700	COG2124	cytochrome p450
SROS_RS33735	COG1595	DNA-templated transcription, initiation
SROS_RS33740	COG1917	Cupin 2, conserved barrel domain protein
SROS_RS33740	COG4977	sequence-specific DNA binding
SROS_RS33745	COG2124	cytochrome p450
SROS_RS33830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SROS_RS33840	COG1396	sequence-specific DNA binding
SROS_RS33850	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
SROS_RS33905	COG2188	Transcriptional regulator
SROS_RS33930	COG1940	carbohydrate kinase activity
SROS_RS33955	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SROS_RS33980	COG0583	DNA-binding transcription factor activity
SROS_RS33985	COG2378	regulation of single-species biofilm formation
SROS_RS33995	COG0754	glutathionylspermidine amidase activity
SROS_RS34000	COG3766	membrane
SROS_RS34015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SROS_RS34020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SROS_RS34025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SROS_RS34105	COG0514	ATP-dependent DNA helicase (RecQ)
SROS_RS34115	COG2175	clavaminate synthase activity
SROS_RS34150	COG0187	DNA topoisomerase II activity
SROS_RS34165	COG3022	response to hydroperoxide
SROS_RS34170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SROS_RS34190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SROS_RS34200	COG1984	allophanate hydrolase subunit 2
SROS_RS34240	COG0477	Major facilitator Superfamily
SROS_RS34255	COG1733	regulation of RNA biosynthetic process
SROS_RS34290	COG1595	DNA-templated transcription, initiation
SROS_RS34295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SROS_RS34305	COG2267	carboxylic ester hydrolase activity
SROS_RS34310	COG1309	transcriptional regulator
SROS_RS34335	COG3226	Transcriptional regulator
SROS_RS34345	COG1595	DNA-templated transcription, initiation
SROS_RS34360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SROS_RS34365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SROS_RS34375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SROS_RS34405	COG0495	leucyl-tRNA aminoacylation
SROS_RS34430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS34435	COG3831	ATPase activity
SROS_RS34445	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS34460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SROS_RS34475	COG0515	serine threonine protein kinase
SROS_RS34480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SROS_RS34485	COG2124	cytochrome p450
SROS_RS34490	COG1131	(ABC) transporter
SROS_RS34500	COG1476	TRANSCRIPTIONal
SROS_RS34525	COG0395	ABC-type sugar transport system, permease component
SROS_RS34530	COG1175	transmembrane transport
SROS_RS34535	COG1653	transport
SROS_RS34575	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS34585	COG1793	dna ligase
SROS_RS34630	COG0515	serine threonine protein kinase
SROS_RS34640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SROS_RS34665	COG0424	maF-like protein
SROS_RS34670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SROS_RS34705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS34715	COG4608	Belongs to the ABC transporter superfamily
SROS_RS34735	COG2197	response regulator
SROS_RS34780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SROS_RS34805	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS34810	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SROS_RS34835	COG1597	lipid kinase activity
SROS_RS34835	COG1803	Methylglyoxal synthase
SROS_RS34860	COG0488	(ABC) transporter
SROS_RS34870	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS34875	COG0789	Transcriptional regulator
SROS_RS34910	COG1595	DNA-templated transcription, initiation
SROS_RS34920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SROS_RS34925	COG2807	transmembrane transport
SROS_RS34945	COG1683	Conserved Protein
SROS_RS34960	COG2205	protein histidine kinase activity
SROS_RS34970	COG2378	regulation of single-species biofilm formation
SROS_RS34985	COG0588	phosphoglycerate mutase activity
SROS_RS34990	COG0799	negative regulation of ribosome biogenesis
SROS_RS34995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SROS_RS35000	COG0501	Belongs to the peptidase M48B family
SROS_RS35005	COG0515	serine threonine protein kinase
SROS_RS35010	COG2259	Doxx family
SROS_RS35025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SROS_RS35030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SROS_RS35035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SROS_RS35040	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SROS_RS35045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SROS_RS35050	COG1530	ribonuclease E activity
SROS_RS35080	COG0772	Belongs to the SEDS family
SROS_RS35085	COG0768	penicillin binding
SROS_RS35095	COG1792	Involved in formation and maintenance of cell shape
SROS_RS35100	COG1077	Cell shape determining protein MreB Mrl
SROS_RS35105	COG0105	UTP biosynthetic process
SROS_RS35120	COG0285	dihydrofolate synthase activity
SROS_RS35140	COG0525	valine-tRNA ligase activity
SROS_RS35150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SROS_RS35155	COG0740	serine-type endopeptidase activity
SROS_RS35160	COG0740	serine-type endopeptidase activity
SROS_RS35165	COG0544	peptidyl-prolyl cis-trans isomerase activity
SROS_RS35215	COG2197	response regulator
SROS_RS35230	COG0628	permease
SROS_RS35265	COG0454	-acetyltransferase
SROS_RS35265	COG0456	acetyltransferase
SROS_RS35270	COG2318	DinB family
SROS_RS35280	COG0750	zinc metalloprotease
SROS_RS35285	COG2197	response regulator
SROS_RS35295	COG4552	Acetyltransferase involved in intracellular survival and related
SROS_RS35305	COG0698	ribose 5-phosphate isomerase
SROS_RS35310	COG0242	peptide deformylase activity
SROS_RS35325	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SROS_RS35355	COG0154	amidase activity
SROS_RS35365	COG0129	dihydroxy-acid dehydratase activity
SROS_RS35395	COG1505	serine-type exopeptidase activity
SROS_RS35430	COG1051	belongs to the nudix hydrolase family
SROS_RS35475	COG0668	transmembrane transport
SROS_RS35485	COG0366	Alpha amylase catalytic
SROS_RS35525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SROS_RS35525	COG1648	precorrin-2 dehydrogenase activity
SROS_RS35530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SROS_RS35550	COG1139	Iron-sulfur cluster binding protein
SROS_RS35555	COG0247	lactate metabolic process
SROS_RS35570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS35585	COG1136	(ABC) transporter
SROS_RS35590	COG2197	response regulator
SROS_RS35605	COG2188	Transcriptional regulator
SROS_RS35625	COG3842	ATPase activity
SROS_RS35630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SROS_RS35675	COG1131	(ABC) transporter
SROS_RS35700	COG1492	cobalamin metabolic process
SROS_RS35780	COG1674	ftsk spoiiie
SROS_RS35805	COG0596	Alpha beta hydrolase
SROS_RS35885	COG1132	(ABC) transporter
SROS_RS35890	COG0515	serine threonine protein kinase
SROS_RS35900	COG1619	proteins homologs of microcin C7 resistance protein MccF
SROS_RS35905	COG4608	Belongs to the ABC transporter superfamily
SROS_RS35915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS35925	COG0747	negative chemotaxis
SROS_RS35930	COG5492	domain, Protein
SROS_RS35965	COG4166	transmembrane transport
SROS_RS35970	COG0601	transmembrane transport
SROS_RS35985	COG4608	Belongs to the ABC transporter superfamily
SROS_RS36045	COG3012	SEC-C Motif Domain Protein
SROS_RS36050	COG2124	cytochrome p450
SROS_RS36055	COG1172	Belongs to the binding-protein-dependent transport system permease family
SROS_RS36060	COG1129	ABC transporter
SROS_RS36080	COG0531	amino acid
SROS_RS36085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SROS_RS36085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SROS_RS36090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SROS_RS36100	COG1414	Transcriptional regulator
SROS_RS36105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SROS_RS36135	COG1846	Transcriptional regulator
SROS_RS36155	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS36160	COG0598	Magnesium transport protein CorA
SROS_RS36170	COG0174	glutamine synthetase
SROS_RS36175	COG4689	acetoacetate decarboxylase
SROS_RS36185	COG1846	Transcriptional regulator
SROS_RS36190	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SROS_RS36200	COG3885	ferrous iron binding
SROS_RS36200	COG2078	PFAM AMMECR1 domain protein
SROS_RS36210	COG0667	Aldo Keto reductase
SROS_RS36215	COG1063	alcohol dehydrogenase
SROS_RS36240	COG0657	acetylesterase activity
SROS_RS36260	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS36285	COG3384	dioxygenase
SROS_RS36290	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS36295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SROS_RS36300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SROS_RS36305	COG1012	belongs to the aldehyde dehydrogenase family
SROS_RS36320	COG0488	(ABC) transporter
SROS_RS36325	COG4257	antibiotic catabolic process
SROS_RS36350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SROS_RS36360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SROS_RS36385	COG1309	transcriptional regulator
SROS_RS36450	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SROS_RS36455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SROS_RS36470	COG1056	cytidyltransferase-related domain
SROS_RS36470	COG1051	belongs to the nudix hydrolase family
SROS_RS36490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SROS_RS36540	COG0254	rRNA binding
SROS_RS36545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SROS_RS36575	COG2814	Major facilitator Superfamily
SROS_RS36580	COG2353	YceI-like domain
SROS_RS36585	COG2897	thiosulfate sulfurtransferase activity
SROS_RS36595	COG0402	S-adenosylhomocysteine deaminase activity
SROS_RS36605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SROS_RS36610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SROS_RS36640	COG2183	response to ionizing radiation
SROS_RS36665	COG1742	UPF0060 membrane protein
SROS_RS36675	COG0789	Transcriptional regulator
SROS_RS36680	COG0667	Aldo Keto reductase
SROS_RS36690	COG4585	Histidine kinase
SROS_RS36695	COG2197	response regulator
SROS_RS36700	COG0737	Belongs to the 5'-nucleotidase family
SROS_RS36705	COG3485	protocatechuate 3,4-dioxygenase
SROS_RS36710	COG3485	protocatechuate 3,4-dioxygenase
SROS_RS36765	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS36775	COG2223	nitrite transmembrane transporter activity
SROS_RS36795	COG0531	amino acid
SROS_RS36810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SROS_RS36820	COG3629	intracellular signal transduction
SROS_RS36835	COG1686	Belongs to the peptidase S11 family
SROS_RS36850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SROS_RS36855	COG0765	amino acid transport
SROS_RS36875	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS36880	COG0604	alcohol dehydrogenase
SROS_RS36885	COG0300	oxidoreductase activity
SROS_RS36885	COG3000	fatty acid hydroxylase
SROS_RS36890	COG2910	NAD(P)H-binding
SROS_RS36930	COG0463	Glycosyl transferase, family 2
SROS_RS37000	COG4221	oxidoreductase activity
SROS_RS37020	COG0515	serine threonine protein kinase
SROS_RS37025	COG0515	serine threonine protein kinase
SROS_RS37040	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SROS_RS37050	COG2197	response regulator
SROS_RS37065	COG1473	amidohydrolase
SROS_RS37130	COG0395	ABC-type sugar transport system, permease component
SROS_RS37135	COG1175	transmembrane transport
SROS_RS37155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SROS_RS37160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SROS_RS37180	COG2154	pterin-4-alpha-carbinolamine dehydratase
SROS_RS37190	COG0395	ABC-type sugar transport system, permease component
SROS_RS37195	COG1175	transmembrane transport
SROS_RS37200	COG1653	transport
SROS_RS37265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SROS_RS37270	COG0395	ABC-type sugar transport system, permease component
SROS_RS37275	COG1175	transmembrane transport
SROS_RS37285	COG1414	Transcriptional regulator
SROS_RS37325	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SROS_RS37335	COG1132	(ABC) transporter
SROS_RS37380	COG1136	(ABC) transporter
SROS_RS37380	COG4591	ABC-type transport system involved in lipoprotein release permease component
SROS_RS37410	COG1309	transcriptional regulator
SROS_RS37445	COG0542	response to heat
SROS_RS37475	COG1309	transcriptional regulator
SROS_RS37510	COG0477	Major facilitator Superfamily
SROS_RS37525	COG1960	acyl-CoA dehydrogenase activity
SROS_RS37530	COG1960	acyl-CoA dehydrogenase activity
SROS_RS37580	COG0653	protein targeting
SROS_RS37585	COG2026	Addiction module toxin, RelE StbE family
SROS_RS37590	COG2161	toxin-antitoxin pair type II binding
SROS_RS37615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SROS_RS37620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS37635	COG1116	anion transmembrane transporter activity
SROS_RS37640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SROS_RS37645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SROS_RS37650	COG0739	heme binding
SROS_RS37715	COG1401	restriction endodeoxyribonuclease activity
SROS_RS37755	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SROS_RS37760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SROS_RS37765	COG1111	helicase
SROS_RS37765	COG1205	dead DEAH box helicase
SROS_RS37790	COG1201	RNA secondary structure unwinding
SROS_RS37800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SROS_RS37810	COG0613	PHP domain protein
SROS_RS37820	COG1349	DNA-binding transcription factor activity
SROS_RS37825	COG0531	amino acid
SROS_RS37830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SROS_RS37840	COG0492	ferredoxin-NADP+ reductase activity
SROS_RS37845	COG1473	amidohydrolase
SROS_RS37855	COG0174	glutamine synthetase
SROS_RS37890	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SROS_RS37900	COG3226	Transcriptional regulator
SROS_RS37905	COG0110	maltose O-acetyltransferase activity
SROS_RS37930	COG1733	regulation of RNA biosynthetic process
SROS_RS37940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS37995	COG3903	Transcriptional regulator
SROS_RS37995	COG3629	intracellular signal transduction
SROS_RS38050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SROS_RS38080	COG0297	glycogen (starch) synthase activity
SROS_RS38085	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS38100	COG1464	Belongs to the NlpA lipoprotein family
SROS_RS38135	COG1294	oxidase, subunit
SROS_RS38140	COG1271	oxidase subunit
SROS_RS38160	COG2130	NADP-dependent
SROS_RS38165	COG1950	PFAM Membrane protein of
SROS_RS38170	COG2986	histidine ammonia-lyase
SROS_RS38175	COG1609	Transcriptional regulator
SROS_RS38190	COG0584	glycerophosphoryl diester phosphodiesterase
SROS_RS38195	COG2807	transmembrane transport
SROS_RS38205	COG0492	ferredoxin-NADP+ reductase activity
SROS_RS38215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SROS_RS38220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SROS_RS38225	COG0183	Belongs to the thiolase family
SROS_RS38230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SROS_RS38235	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SROS_RS38240	COG1414	Transcriptional regulator
SROS_RS38245	COG1609	Transcriptional regulator
SROS_RS38260	COG0395	ABC-type sugar transport system, permease component
SROS_RS38265	COG1175	transmembrane transport
SROS_RS38305	COG0768	penicillin binding
SROS_RS38310	COG0789	Transcriptional regulator
SROS_RS38315	COG0667	Aldo Keto reductase
SROS_RS38325	COG2723	6-phospho-beta-galactosidase activity
SROS_RS38330	COG0656	L-ascorbic acid biosynthetic process
SROS_RS38340	COG0789	Transcriptional regulator
SROS_RS38350	COG0596	Alpha beta hydrolase
SROS_RS38360	COG0702	epimerase
SROS_RS38365	COG1309	transcriptional regulator
SROS_RS38410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SROS_RS38415	COG0857	belongs to the CobB CobQ family
SROS_RS38415	COG0280	phosphate acetyltransferase
SROS_RS38425	COG1021	2,3-dihydroxybenzoate-AMP ligase
SROS_RS38430	COG1217	gtp-binding protein TYPA
SROS_RS38435	COG2032	superoxide dismutase activity
SROS_RS38465	COG0726	polysaccharide deacetylase
SROS_RS38475	COG1595	DNA-templated transcription, initiation
SROS_RS38485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SROS_RS38490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS38495	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SROS_RS38500	COG1120	ATPase activity
SROS_RS38510	COG1196	nuclear chromosome segregation
SROS_RS38525	COG1254	Belongs to the acylphosphatase family
SROS_RS38530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SROS_RS38535	COG0571	ribonuclease III activity
SROS_RS38545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SROS_RS38550	COG0742	ribosomal rna small subunit methyltransferase
SROS_RS38560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SROS_RS38565	COG1461	Dihydroxyacetone kinase
SROS_RS38570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SROS_RS38575	COG0351	phosphomethylpyrimidine kinase
SROS_RS38600	COG1181	Belongs to the D-alanine--D-alanine ligase family
SROS_RS38610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SROS_RS38620	COG1920	GTP binding
SROS_RS38635	COG0776	regulation of translation
SROS_RS38640	COG0066	3-isopropylmalate dehydratase activity
SROS_RS38645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SROS_RS38650	COG1414	Transcriptional regulator
SROS_RS38680	COG0339	signal peptide processing
SROS_RS38690	COG0534	Mate efflux family protein
SROS_RS38695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SROS_RS38700	COG0179	Fumarylacetoacetate (FAA) hydrolase
SROS_RS38705	COG1302	Protein conserved in bacteria
SROS_RS38750	COG1335	isochorismatase
SROS_RS38760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SROS_RS38775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SROS_RS38780	COG0473	3-isopropylmalate dehydrogenase activity
SROS_RS38795	COG0477	Major facilitator Superfamily
SROS_RS38800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SROS_RS38820	COG1136	(ABC) transporter
SROS_RS38820	COG4591	ABC-type transport system involved in lipoprotein release permease component
SROS_RS38835	COG2211	Major facilitator Superfamily
SROS_RS38840	COG2027	D-alanyl-D-alanine carboxypeptidase
SROS_RS38850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SROS_RS38855	COG0440	acetolactate synthase activity
SROS_RS38865	COG5001	Diguanylate cyclase
SROS_RS38875	COG2133	pyrroloquinoline quinone binding
SROS_RS38880	COG2720	vancomycin resistance protein
SROS_RS38885	COG4565	transcriptional regulatory protein
SROS_RS38890	COG3290	protein histidine kinase activity
SROS_RS38920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SROS_RS38930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SROS_RS38935	COG0154	amidase activity
SROS_RS38940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SROS_RS38950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SROS_RS38960	COG1404	Belongs to the peptidase S8 family
SROS_RS38965	COG2815	serine threonine protein kinase
SROS_RS38965	COG0515	serine threonine protein kinase
SROS_RS38970	COG2815	serine threonine protein kinase
SROS_RS38970	COG0515	serine threonine protein kinase
SROS_RS39070	COG1674	ftsk spoiiie
SROS_RS39100	COG0482	sulfurtransferase activity
SROS_RS39125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SROS_RS39140	COG0515	serine threonine protein kinase
SROS_RS39140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SROS_RS39160	COG2362	D-Aminopeptidase
SROS_RS39180	COG1162	GTPase activity
SROS_RS39185	COG2226	methyltransferase
SROS_RS39190	COG0438	transferase activity, transferring glycosyl groups
SROS_RS39200	COG3842	ATPase activity
SROS_RS39235	COG2311	Membrane
SROS_RS39255	COG0058	SHG alpha-glucan phosphorylase activity
SROS_RS39260	COG0366	Alpha amylase catalytic
SROS_RS39270	COG3281	Trehalose synthase
SROS_RS39290	COG4585	Histidine kinase
SROS_RS39295	COG2197	response regulator
SROS_RS39315	COG0789	Transcriptional regulator
SROS_RS39350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SROS_RS39360	COG2076	Multidrug Resistance protein
SROS_RS39370	COG0590	tRNA wobble adenosine to inosine editing
SROS_RS39375	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SROS_RS39400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SROS_RS39420	COG0616	signal peptide processing
SROS_RS39440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SROS_RS39450	COG1174	glycine betaine transport
SROS_RS39455	COG1174	glycine betaine transport
SROS_RS39470	COG1404	Belongs to the peptidase S8 family
SROS_RS39480	COG1522	sequence-specific DNA binding
SROS_RS39495	COG0577	efflux transmembrane transporter activity
SROS_RS39495	COG1136	(ABC) transporter
SROS_RS39500	COG0577	efflux transmembrane transporter activity
SROS_RS39500	COG1136	(ABC) transporter
SROS_RS39540	COG2030	dehydratase
SROS_RS39545	COG1960	acyl-CoA dehydrogenase activity
SROS_RS39550	COG1960	acyl-CoA dehydrogenase activity
SROS_RS39555	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS39560	COG1309	transcriptional regulator
SROS_RS39565	COG0183	Belongs to the thiolase family
SROS_RS39575	COG2186	Transcriptional regulator
SROS_RS39615	COG1172	Belongs to the binding-protein-dependent transport system permease family
SROS_RS39620	COG1129	ABC transporter
SROS_RS39635	COG4948	Mandelate Racemase Muconate Lactonizing
SROS_RS39640	COG0179	Fumarylacetoacetate (FAA) hydrolase
SROS_RS39650	COG2124	cytochrome p450
SROS_RS39665	COG3311	Transcriptional regulator
SROS_RS39670	COG2124	cytochrome p450
SROS_RS39715	COG0438	transferase activity, transferring glycosyl groups
SROS_RS39735	COG0395	ABC-type sugar transport system, permease component
SROS_RS39740	COG1175	transmembrane transport
SROS_RS39750	COG3250	beta-galactosidase activity
SROS_RS39755	COG1070	Carbohydrate kinase
SROS_RS39765	COG1349	DNA-binding transcription factor activity
SROS_RS39770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SROS_RS39780	COG2197	response regulator
SROS_RS39785	COG4585	Histidine kinase
SROS_RS39815	COG3547	Transposase (IS116 IS110 IS902 family)
SROS_RS39835	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SROS_RS39845	COG0673	inositol 2-dehydrogenase activity
SROS_RS39855	COG1172	Belongs to the binding-protein-dependent transport system permease family
SROS_RS39860	COG1129	ABC transporter
SROS_RS39865	COG1940	carbohydrate kinase activity
SROS_RS39875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SROS_RS39885	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS39920	COG0431	NADPH-dependent FMN reductase
SROS_RS39930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SROS_RS39945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SROS_RS39950	COG0435	Glutathione S-transferase
SROS_RS39975	COG0508	dehydrogenase complex catalyzes the overall conversion of
SROS_RS39975	COG0567	Dehydrogenase, E1 component
SROS_RS39995	COG0604	alcohol dehydrogenase
SROS_RS40060	COG2172	sigma factor antagonist activity
SROS_RS40075	COG1597	lipid kinase activity
SROS_RS40090	COG0156	8-amino-7-oxononanoate synthase activity
SROS_RS40095	COG2188	Transcriptional regulator
SROS_RS40100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SROS_RS40105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SROS_RS40135	COG0511	ligase activity, forming carbon-carbon bonds
SROS_RS40140	COG0439	Biotin carboxylase
SROS_RS40155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SROS_RS40160	COG5662	AntiSigma factor
SROS_RS40165	COG1595	DNA-templated transcription, initiation
SROS_RS40180	COG2135	peptidase activity
SROS_RS40185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SROS_RS40195	COG0483	inositol monophosphate 1-phosphatase activity
SROS_RS40215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SROS_RS40285	COG1615	UPF0182 protein
SROS_RS40290	COG3480	Lon protease (S16) C-terminal proteolytic domain
SROS_RS40340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SROS_RS40360	COG1946	Acyl-CoA thioesterase
SROS_RS40390	COG4264	IucA IucC family
SROS_RS40400	COG0019	diaminopimelate decarboxylase activity
SROS_RS40430	COG2267	carboxylic ester hydrolase activity
SROS_RS40435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SROS_RS40450	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SROS_RS40475	COG1404	Belongs to the peptidase S8 family
SROS_RS40500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SROS_RS40550	COG2095	MarC family integral membrane protein
SROS_RS40580	COG2301	Belongs to the HpcH HpaI aldolase family
SROS_RS40585	COG1268	BioY protein
SROS_RS40600	COG2239	Acts as a magnesium transporter
SROS_RS40620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SROS_RS40625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SROS_RS40640	COG1595	DNA-templated transcription, initiation
SROS_RS40650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SROS_RS40660	COG1024	Enoyl-CoA hydratase
SROS_RS40665	COG2814	Major facilitator Superfamily
SROS_RS40670	COG0583	DNA-binding transcription factor activity
SROS_RS40675	COG2818	Glycosylase
SROS_RS40690	COG1611	Belongs to the LOG family
SROS_RS40695	COG1611	Belongs to the LOG family
SROS_RS40700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SROS_RS40705	COG0789	Transcriptional regulator
SROS_RS40710	COG2171	N-acyltransferase activity
SROS_RS40745	COG2226	methyltransferase
SROS_RS40755	COG0210	DNA helicase
SROS_RS40765	COG0215	cysteine-tRNA ligase activity
SROS_RS40775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SROS_RS40800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SROS_RS40815	COG1132	(ABC) transporter
SROS_RS40820	COG1132	(ABC) transporter
SROS_RS40830	COG0542	response to heat
SROS_RS40835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SROS_RS40840	COG1053	succinate dehydrogenase
SROS_RS40850	COG0583	DNA-binding transcription factor activity
SROS_RS40860	COG4251	negative regulation of phosphorylation
SROS_RS40865	COG0784	Response regulator, receiver
SROS_RS40945	COG1322	Protein conserved in bacteria
SROS_RS40955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SROS_RS40965	COG1570	exodeoxyribonuclease VII activity
SROS_RS40975	COG1722	exodeoxyribonuclease VII activity
SROS_RS41005	COG2223	nitrite transmembrane transporter activity
SROS_RS41010	COG3718	enzyme involved in inositol metabolism
SROS_RS41020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SROS_RS41030	COG0673	inositol 2-dehydrogenase activity
SROS_RS41035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS41050	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SROS_RS41050	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SROS_RS41080	COG0604	alcohol dehydrogenase
SROS_RS41095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SROS_RS41110	COG0114	fumarate hydratase activity
SROS_RS41120	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS41135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SROS_RS41155	COG0745	RESPONSE REGULATOR receiver
SROS_RS41160	COG2205	protein histidine kinase activity
SROS_RS41170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SROS_RS41175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SROS_RS41200	COG3220	belongs to the UPF0276 family
SROS_RS41210	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SROS_RS41220	COG1309	transcriptional regulator
SROS_RS41230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SROS_RS41240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SROS_RS41260	COG1331	Highly conserved protein containing a thioredoxin domain
SROS_RS41265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SROS_RS41275	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SROS_RS41280	COG1714	RDD family
SROS_RS41285	COG0308	aminopeptidase N
SROS_RS41290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SROS_RS41320	COG1136	(ABC) transporter
SROS_RS41330	COG0577	efflux transmembrane transporter activity
SROS_RS41335	COG1396	sequence-specific DNA binding
SROS_RS41350	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SROS_RS41390	COG2755	lipolytic protein G-D-S-L family
SROS_RS41400	COG0183	Belongs to the thiolase family
SROS_RS41405	COG3467	pyridoxamine 5'-phosphate
SROS_RS41425	COG0242	peptide deformylase activity
SROS_RS41430	COG3830	Belongs to the UPF0237 family
SROS_RS41465	COG0148	phosphopyruvate hydratase activity
SROS_RS41495	COG0529	Catalyzes the synthesis of activated sulfate
SROS_RS41500	COG0730	response to heat
SROS_RS41565	COG1218	3'(2'),5'-bisphosphate nucleotidase
SROS_RS41570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SROS_RS41580	COG0193	aminoacyl-tRNA hydrolase activity
SROS_RS41585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SROS_RS41590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SROS_RS41595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SROS_RS41615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SROS_RS41630	COG4106	trans-aconitate 2-methyltransferase activity
SROS_RS41635	COG1846	Transcriptional regulator
SROS_RS41640	COG0488	(ABC) transporter
SROS_RS41645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SROS_RS41650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SROS_RS41665	COG0084	hydrolase, TatD family'
SROS_RS41670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SROS_RS41705	COG0628	permease
SROS_RS41715	COG1414	Transcriptional regulator
SROS_RS41745	COG1396	sequence-specific DNA binding
SROS_RS41750	COG0740	serine-type endopeptidase activity
SROS_RS41755	COG0740	serine-type endopeptidase activity
SROS_RS41765	COG0596	Alpha beta hydrolase
SROS_RS41790	COG0521	Mo-molybdopterin cofactor biosynthetic process
SROS_RS41795	COG0315	cyclic pyranopterin monophosphate synthase activity
SROS_RS41805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SROS_RS41810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SROS_RS41815	COG3263	regulation of cellular component size
SROS_RS41825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SROS_RS41840	COG1876	peptidase activity
SROS_RS41905	COG0494	nUDIX hydrolase
SROS_RS41950	COG0482	sulfurtransferase activity
SROS_RS41970	COG1061	Type III restriction enzyme res subunit
SROS_RS42030	COG4221	oxidoreductase activity
SROS_RS42040	COG2909	trisaccharide binding
SROS_RS42055	COG1595	DNA-templated transcription, initiation
SROS_RS42080	COG4129	membrane
SROS_RS42115	COG4585	Histidine kinase
SROS_RS42130	COG0752	glycyl-tRNA synthetase alpha subunit
SROS_RS42130	COG0751	glycine-tRNA ligase activity
SROS_RS42135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS42140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SROS_RS42155	COG4213	ABC transporter substrate-binding protein
SROS_RS42160	COG1846	Transcriptional regulator
SROS_RS42185	COG2353	YceI-like domain
SROS_RS42190	COG1733	regulation of RNA biosynthetic process
SROS_RS42245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SROS_RS42255	COG0546	phosphoglycolate phosphatase activity
SROS_RS42260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SROS_RS42310	COG0745	RESPONSE REGULATOR receiver
SROS_RS42315	COG2205	protein histidine kinase activity
SROS_RS42390	COG0640	Transcriptional regulator
SROS_RS42415	COG1228	amidohydrolase
SROS_RS42420	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SROS_RS42430	COG1122	ATPase activity
SROS_RS42435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SROS_RS42455	COG2197	response regulator
SROS_RS42460	COG1271	oxidase subunit
SROS_RS42465	COG1294	oxidase, subunit
SROS_RS42475	COG4585	Histidine kinase
SROS_RS42480	COG2197	response regulator
SROS_RS42485	COG2197	response regulator
SROS_RS42535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SROS_RS42535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SROS_RS42615	COG1819	glycosyl
SROS_RS42630	COG0318	PFAM AMP-dependent synthetase and ligase
SROS_RS42660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SROS_RS42715	COG0179	Fumarylacetoacetate (FAA) hydrolase
SROS_RS42720	COG1376	ErfK ybiS ycfS ynhG family protein
SROS_RS42740	COG1063	alcohol dehydrogenase
SROS_RS42745	COG0156	8-amino-7-oxononanoate synthase activity
SROS_RS42750	COG0583	DNA-binding transcription factor activity
SROS_RS42795	COG2267	carboxylic ester hydrolase activity
SROS_RS42815	COG2124	cytochrome p450
SROS_RS42830	COG0745	RESPONSE REGULATOR receiver
SROS_RS42840	COG1136	(ABC) transporter
SROS_RS42840	COG0577	efflux transmembrane transporter activity
SROS_RS42845	COG0577	efflux transmembrane transporter activity
SROS_RS42845	COG1136	(ABC) transporter
SROS_RS42860	COG2205	protein histidine kinase activity
SROS_RS42865	COG0745	RESPONSE REGULATOR receiver
SROS_RS42870	COG0579	oxidoreductase
SROS_RS42895	COG0667	Aldo Keto reductase
SROS_RS42935	COG2252	PERMEase
SROS_RS42950	COG0640	Transcriptional regulator
SROS_RS42970	COG2814	Major facilitator Superfamily
SROS_RS42975	COG1278	Cold shock
SROS_RS42985	COG1309	transcriptional regulator
SROS_RS43000	COG1061	Type III restriction enzyme res subunit
SROS_RS43005	COG3973	AAA domain
SROS_RS43015	COG0459	protein refolding
SROS_RS43025	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SROS_RS43085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SROS_RS43085	COG1877	trehalose-phosphatase activity
SROS_RS43115	COG4608	Belongs to the ABC transporter superfamily
SROS_RS43125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SROS_RS43145	COG1134	teichoic acid transport
SROS_RS43150	COG1881	PFAM PEBP family protein
SROS_RS43175	COG0416	fatty acid biosynthetic process
SROS_RS43180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SROS_RS43185	COG0018	arginyl-trna synthetase
SROS_RS43195	COG1799	cell septum assembly
SROS_RS43200	COG0384	phenazine biosynthesis protein PhzF
SROS_RS43225	COG0667	Aldo Keto reductase
SROS_RS43245	COG0243	molybdopterin cofactor binding
SROS_RS43280	COG1960	acyl-CoA dehydrogenase activity
SROS_RS43305	COG1309	transcriptional regulator
SROS_RS43315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SROS_RS43335	COG1132	(ABC) transporter
SROS_RS43340	COG0508	dehydrogenase complex catalyzes the overall conversion of
SROS_RS43345	COG0022	dehydrogenase e1 component
SROS_RS43355	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SROS_RS43365	COG0047	phosphoribosylformylglycinamidine synthase activity
SROS_RS43370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SROS_RS43395	COG2814	Major facilitator Superfamily
SROS_RS43410	COG1309	transcriptional regulator
SROS_RS43440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SROS_RS43465	COG1309	transcriptional regulator
SROS_RS43480	COG0860	N-Acetylmuramoyl-L-alanine amidase
SROS_RS43490	COG2608	mercury ion transmembrane transporter activity
SROS_RS43495	COG0167	dihydroorotate dehydrogenase activity
SROS_RS43540	COG0681	Belongs to the peptidase S26 family
SROS_RS43550	COG3387	PFAM Glycoside hydrolase 15-related
SROS_RS43560	COG0656	L-ascorbic acid biosynthetic process
SROS_RS43585	COG1846	Transcriptional regulator
SROS_RS43590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SROS_RS43620	COG0725	ABC transporter, periplasmic molybdate-binding protein
SROS_RS43630	COG2353	YceI-like domain
SROS_RS43660	COG1959	2 iron, 2 sulfur cluster binding
SROS_RS43685	COG3467	pyridoxamine 5'-phosphate
SROS_RS43690	COG1846	Transcriptional regulator
SROS_RS43695	COG2409	Drug exporters of the RND superfamily
SROS_RS43700	COG2124	cytochrome p450
SROS_RS43705	COG0477	Major facilitator Superfamily
SROS_RS43760	COG1960	acyl-CoA dehydrogenase activity
SROS_RS43765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SROS_RS43765	COG1199	ATP-dependent helicase activity
SROS_RS43785	COG1324	tolerance protein
SROS_RS43815	COG0179	Fumarylacetoacetate (FAA) hydrolase
SROS_RS43845	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SROS_RS43850	COG0492	ferredoxin-NADP+ reductase activity
SROS_RS43895	COG2188	Transcriptional regulator
SROS_RS43900	COG2182	Extracellular solute-binding protein
SROS_RS43905	COG1175	transmembrane transport
SROS_RS43910	COG0395	ABC-type sugar transport system, permease component
SROS_RS43915	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SROS_RS43940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SROS_RS43955	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SROS_RS43960	COG0028	Belongs to the TPP enzyme family
SROS_RS43985	COG3842	ATPase activity
SROS_RS43995	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
SROS_RS44010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SROS_RS44015	COG4569	acetaldehyde dehydrogenase (acetylating) activity
SROS_RS44030	COG1414	Transcriptional regulator
SROS_RS44055	COG2442	InterPro IPR007367
SROS_RS44075	COG2188	Transcriptional regulator
SROS_RS44100	COG1937	Protein conserved in bacteria
SROS_RS44105	COG0438	transferase activity, transferring glycosyl groups
SROS_RS44115	COG2181	nitrate reductase activity
SROS_RS44115	COG0247	lactate metabolic process
SROS_RS44125	COG1082	Xylose isomerase domain protein TIM barrel
SROS_RS44140	COG3118	belongs to the thioredoxin family
SROS_RS44145	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SROS_RS44150	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SROS_RS44185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SROS_RS44205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SROS_RS44210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SROS_RS44215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SROS_RS44225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SROS_RS44230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SROS_RS44245	COG1619	proteins homologs of microcin C7 resistance protein MccF
SROS_RS44250	COG2124	cytochrome p450
SROS_RS44255	COG0861	Integral membrane protein TerC family
SROS_RS44265	COG0649	NAD binding
SROS_RS44280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SROS_RS44295	COG0302	gtp cyclohydrolase
SROS_RS44310	COG0037	tRNA processing
SROS_RS44320	COG2027	D-alanyl-D-alanine carboxypeptidase
SROS_RS44325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SROS_RS44395	COG0596	Alpha beta hydrolase
SROS_RS44420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SROS_RS44485	COG1774	PSP1 C-terminal conserved region
SROS_RS44510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SROS_RS44515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SROS_RS44520	COG1408	metallophosphoesterase
SROS_RS44525	COG1754	DNA topoisomerase type I activity
SROS_RS44525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SROS_RS44545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SROS_RS44560	COG0431	NADPH-dependent FMN reductase
SROS_RS44580	COG0438	transferase activity, transferring glycosyl groups
SROS_RS44585	COG2814	Major facilitator Superfamily
SROS_RS44590	COG0156	8-amino-7-oxononanoate synthase activity
SROS_RS44600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SROS_RS44620	COG0596	Alpha beta hydrolase
SROS_RS44635	COG0477	Major facilitator Superfamily
SROS_RS44685	COG1132	(ABC) transporter
SROS_RS44725	COG0640	Transcriptional regulator
SROS_RS44730	COG2271	Major facilitator Superfamily
SROS_RS44745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SROS_RS44775	COG1316	TRANSCRIPTIONal
SROS_RS44815	COG0477	Major facilitator Superfamily
SROS_RS44820	COG1733	regulation of RNA biosynthetic process
SROS_RS44845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SROS_RS44850	COG0583	DNA-binding transcription factor activity
SROS_RS44870	COG3903	Transcriptional regulator
SROS_RS44870	COG3629	intracellular signal transduction
SROS_RS44875	COG2890	protein-(glutamine-N5) methyltransferase activity
SROS_RS44885	COG1309	transcriptional regulator
SROS_RS44920	COG3339	Conserved Protein
SROS_RS44940	COG1309	transcriptional regulator
SROS_RS44965	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SROS_RS44970	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SROS_RS45020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SROS_RS45040	COG2186	Transcriptional regulator
SROS_RS45045	COG0592	DNA-directed DNA polymerase activity
SROS_RS45050	COG2197	response regulator
SROS_RS45055	COG2197	response regulator
SROS_RS45070	COG0842	Transport permease protein
SROS_RS45075	COG1309	transcriptional regulator
SROS_RS45080	COG1028	Short-chain dehydrogenase reductase Sdr
SROS_RS45095	COG1733	regulation of RNA biosynthetic process
SROS_RS45100	COG0604	alcohol dehydrogenase
SROS_RS45105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SROS_RS45115	COG0702	epimerase
SROS_RS45125	COG0137	argininosuccinate synthase activity
SROS_RS45130	COG0586	Pfam SNARE associated Golgi protein
SROS_RS45140	COG0305	Participates in initiation and elongation during chromosome replication
SROS_RS45150	COG0531	amino acid
SROS_RS45160	COG0765	amino acid transport
SROS_RS45170	COG0359	binds to the 23S rRNA
SROS_RS45175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SROS_RS45180	COG0629	single-stranded DNA binding
SROS_RS45185	COG0360	Binds together with S18 to 16S ribosomal RNA
SROS_RS45215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SROS_RS45230	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SROS_RS45240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SROS_RS45265	COG2815	serine threonine protein kinase
SROS_RS45265	COG0515	serine threonine protein kinase
SROS_RS45270	COG1595	DNA-templated transcription, initiation
SROS_RS45280	COG0492	ferredoxin-NADP+ reductase activity
SROS_RS45285	COG3118	belongs to the thioredoxin family
SROS_RS45295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SROS_RS45320	COG1192	Involved in chromosome partitioning
SROS_RS45325	COG0357	Ribosomal RNA small subunit methyltransferase G
SROS_RS45335	COG0706	membrane insertase activity
SROS_RS45340	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SROS_RS45425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SROS_RS45525	COG1525	nuclease
SROS_RS45555	COG2197	response regulator
SROS_RS45670	COG2267	carboxylic ester hydrolase activity
SROS_RS45680	COG2815	serine threonine protein kinase
SROS_RS45680	COG0515	serine threonine protein kinase
SROS_RS45690	COG1215	transferase activity, transferring glycosyl groups
SROS_RS45740	COG3594	Acyltransferase
SROS_RS45745	COG0515	serine threonine protein kinase
SROS_RS45745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SROS_RS45765	COG2815	serine threonine protein kinase
SROS_RS45765	COG0515	serine threonine protein kinase
SROS_RS45770	COG0515	serine threonine protein kinase
SROS_RS45775	COG0791	NLP P60 protein
SROS_RS45775	COG3883	PFAM NLP P60 protein
SROS_RS45780	COG4585	Histidine kinase
SROS_RS45850	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SROS_RS45850	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SROS_RS45875	COG2815	serine threonine protein kinase
SROS_RS45875	COG0515	serine threonine protein kinase
SROS_RS45880	COG4585	Histidine kinase
SROS_RS45920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SROS_RS45940	COG0515	serine threonine protein kinase
SROS_RS45940	COG2815	serine threonine protein kinase
SROS_RS45985	COG2186	Transcriptional regulator
SROS_RS46005	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SROS_RS46005	COG0515	serine threonine protein kinase
SROS_RS46045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SROS_RS46125	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SROS_RS46160	COG2815	serine threonine protein kinase
SROS_RS46160	COG0515	serine threonine protein kinase
SROS_RS46190	COG1404	Belongs to the peptidase S8 family
SROS_RS46205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SROS_RS46260	COG1802	Transcriptional regulator
SROS_RS46275	COG0443	Heat shock 70 kDa protein
SROS_RS46345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SROS_RS46365	COG2815	serine threonine protein kinase
SROS_RS46365	COG0515	serine threonine protein kinase
SROS_RS46375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SROS_RS46430	COG0629	single-stranded DNA binding
SROS_RS46435	COG1556	Lactate utilization protein
SROS_RS46485	COG4585	Histidine kinase
SROS_RS46520	COG3629	intracellular signal transduction
SROS_RS46520	COG3903	Transcriptional regulator
SROS_RS46525	COG0515	serine threonine protein kinase
SROS_RS46570	COG2340	Cysteine-rich secretory protein family
SROS_RS46575	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SROS_RS46600	COG0515	serine threonine protein kinase
SROS_RS46600	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SROS_RS46645	COG0515	serine threonine protein kinase
SROS_RS46710	COG2409	Drug exporters of the RND superfamily
SROS_RS46745	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SROS_RS46775	COG3883	PFAM NLP P60 protein
SROS_RS46775	COG0791	NLP P60 protein
SROS_RS46800	COG0318	PFAM AMP-dependent synthetase and ligase