locus-tag	class	description
I6G33_RS00005	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6G33_RS00010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G33_RS00015	COG0459	protein refolding
I6G33_RS00050	COG1704	LemA family
I6G33_RS00060	COG3300	MHYT domain
I6G33_RS00060	COG5001	Diguanylate cyclase
I6G33_RS00075	COG0583	DNA-binding transcription factor activity
I6G33_RS00085	COG4625	pathogenesis
I6G33_RS00085	COG3240	lipase activity
I6G33_RS00090	COG3706	GGDEF domain
I6G33_RS00095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G33_RS00110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G33_RS00110	COG1017	nitric oxide dioxygenase activity
I6G33_RS00125	COG0469	pyruvate kinase activity
I6G33_RS00135	COG2084	Dehydrogenase
I6G33_RS00140	COG3622	Belongs to the hyi family
I6G33_RS00145	COG3960	tartronate-semialdehyde synthase activity
I6G33_RS00150	COG0583	DNA-binding transcription factor activity
I6G33_RS00155	COG2351	hydroxyisourate hydrolase activity
I6G33_RS00185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G33_RS00200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G33_RS00205	COG0402	S-adenosylhomocysteine deaminase activity
I6G33_RS00250	COG1295	ribonuclease BN
I6G33_RS00265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G33_RS00280	COG0442	prolyl-tRNA aminoacylation
I6G33_RS00295	COG2900	Belongs to the SlyX family
I6G33_RS00300	COG1278	Cold shock
I6G33_RS00305	COG0783	Belongs to the Dps family
I6G33_RS00310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G33_RS00320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6G33_RS00325	COG0632	four-way junction helicase activity
I6G33_RS00330	COG2255	four-way junction helicase activity
I6G33_RS00335	COG0824	Thioesterase
I6G33_RS00355	COG0823	Involved in the tonB-independent uptake of proteins
I6G33_RS00360	COG2885	chlorophyll binding
I6G33_RS00365	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6G33_RS00370	COG0602	queuosine metabolic process
I6G33_RS00375	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6G33_RS00385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6G33_RS00395	COG0425	Belongs to the sulfur carrier protein TusA family
I6G33_RS00400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G33_RS00410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G33_RS00420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G33_RS00430	COG1335	isochorismatase
I6G33_RS00440	COG0417	DNA replication proofreading
I6G33_RS00445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G33_RS00475	COG3174	membrane
I6G33_RS00480	COG2205	protein histidine kinase activity
I6G33_RS00480	COG0784	Response regulator, receiver
I6G33_RS00500	COG2814	Major facilitator Superfamily
I6G33_RS00505	COG2974	May be involved in recombination
I6G33_RS00520	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G33_RS00540	COG0556	nucleotide-excision repair
I6G33_RS00545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G33_RS00575	COG0582	viral genome integration into host DNA
I6G33_RS00600	COG2135	peptidase activity
I6G33_RS00625	COG0842	Transport permease protein
I6G33_RS00630	COG0842	Transport permease protein
I6G33_RS00635	COG1131	(ABC) transporter
I6G33_RS00645	COG1309	transcriptional regulator
I6G33_RS00690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G33_RS00710	COG3005	denitrification pathway
I6G33_RS00720	COG0243	molybdopterin cofactor binding
I6G33_RS00725	COG3062	negative regulation of establishment of protein localization
I6G33_RS00730	COG4459	periplasmic nitrate reductase
I6G33_RS00735	COG3091	SprT-like family
I6G33_RS00755	COG0037	tRNA processing
I6G33_RS00760	COG2258	MOSC domain
I6G33_RS00765	COG0537	adenosine 5'-monophosphoramidase activity
I6G33_RS00785	COG2733	membrane
I6G33_RS00830	COG3100	YcgL domain-containing protein
I6G33_RS00840	COG2983	Belongs to the UPF0260 family
I6G33_RS00850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G33_RS00855	COG0527	aspartate kinase activity
I6G33_RS00860	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6G33_RS00885	COG2239	Acts as a magnesium transporter
I6G33_RS00905	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6G33_RS00925	COG0835	chemotaxis
I6G33_RS00925	COG0784	Response regulator, receiver
I6G33_RS00930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G33_RS00950	COG1749	Flagellar hook protein flgE
I6G33_RS00955	COG4787	bacterial-type flagellum-dependent cell motility
I6G33_RS00960	COG4786	Flagellar basal body rod
I6G33_RS00965	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6G33_RS00970	COG1706	bacterial-type flagellum-dependent cell motility
I6G33_RS00980	COG1256	bacterial-type flagellum assembly
I6G33_RS00990	COG1555	photosystem II stabilization
I6G33_RS01025	COG1362	aminopeptidase activity
I6G33_RS01030	COG0564	pseudouridine synthase activity
I6G33_RS01035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6G33_RS01040	COG2894	cell division
I6G33_RS01045	COG0850	regulation of cytokinetic process
I6G33_RS01050	COG1560	Kdo2-lipid A biosynthetic process
I6G33_RS01055	COG2853	Lipoprotein
I6G33_RS01065	COG3162	membrane
I6G33_RS01070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G33_RS01090	COG3089	Belongs to the UPF0270 family
I6G33_RS01100	COG1363	Peptidase, m42
I6G33_RS01105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G33_RS01105	COG0189	ligase activity
I6G33_RS01110	COG0367	asparagine synthase
I6G33_RS01115	COG0583	DNA-binding transcription factor activity
I6G33_RS01135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6G33_RS01135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G33_RS01140	COG0784	Response regulator, receiver
I6G33_RS01140	COG2205	protein histidine kinase activity
I6G33_RS01140	COG5002	protein histidine kinase activity
I6G33_RS01145	COG2860	membrane
I6G33_RS01155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G33_RS01160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G33_RS01165	COG3956	TIGRFAM MazG family protein
I6G33_RS01195	COG1201	RNA secondary structure unwinding
I6G33_RS01200	COG1793	dna ligase
I6G33_RS01205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6G33_RS01205	COG1793	dna ligase
I6G33_RS01215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G33_RS01225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G33_RS01240	COG1805	sodium ion transport
I6G33_RS01265	COG1477	protein flavinylation
I6G33_RS01275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G33_RS01280	COG0584	glycerophosphoryl diester phosphodiesterase
I6G33_RS01295	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G33_RS01300	COG1136	(ABC) transporter
I6G33_RS01315	COG0658	competence protein
I6G33_RS01315	COG2333	competence protein COMEC
I6G33_RS01320	COG0811	peptide transport
I6G33_RS01325	COG0848	biopolymer transport protein
I6G33_RS01330	COG1663	tetraacyldisaccharide 4'-kinase activity
I6G33_RS01335	COG2835	tetraacyldisaccharide 4'-kinase activity
I6G33_RS01340	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6G33_RS01345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G33_RS01350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G33_RS01355	COG0069	glutamate synthase activity
I6G33_RS01360	COG1530	ribonuclease E activity
I6G33_RS01370	COG0546	phosphoglycolate phosphatase activity
I6G33_RS01375	COG0616	signal peptide processing
I6G33_RS01375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G33_RS01380	COG0424	maF-like protein
I6G33_RS01390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G33_RS01395	COG0416	fatty acid biosynthetic process
I6G33_RS01410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G33_RS01415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G33_RS01425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G33_RS01430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G33_RS01445	COG0084	hydrolase, TatD family'
I6G33_RS01450	COG1113	amino acid transport
I6G33_RS01505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G33_RS01515	COG3300	MHYT domain
I6G33_RS01515	COG5001	Diguanylate cyclase
I6G33_RS01530	COG2130	NADP-dependent
I6G33_RS01540	COG3135	benzoate transporter
I6G33_RS01545	COG1677	Flagellar hook-basal body complex protein FliE
I6G33_RS01580	COG0745	RESPONSE REGULATOR receiver
I6G33_RS01620	COG1987	bacterial-type flagellum assembly
I6G33_RS01635	COG2032	superoxide dismutase activity
I6G33_RS01665	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6G33_RS01670	COG2198	Histidine kinase
I6G33_RS01670	COG0784	Response regulator, receiver
I6G33_RS01670	COG0643	Histidine kinase
I6G33_RS01675	COG2201	protein-glutamate methylesterase activity
I6G33_RS01680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G33_RS01685	COG1360	Flagellar Motor Protein
I6G33_RS01690	COG1192	Involved in chromosome partitioning
I6G33_RS01700	COG0835	chemotaxis
I6G33_RS01725	COG4133	protoheme IX ABC transporter activity
I6G33_RS01745	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6G33_RS01795	COG0500	methyltransferase
I6G33_RS01805	COG0501	Belongs to the peptidase M48B family
I6G33_RS01815	COG0436	Aminotransferase
I6G33_RS01820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G33_RS01830	COG0625	glutathione transferase activity
I6G33_RS01855	COG0640	Transcriptional regulator
I6G33_RS01890	COG1136	(ABC) transporter
I6G33_RS01895	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G33_RS01920	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I6G33_RS01940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G33_RS01945	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6G33_RS01960	COG1570	exodeoxyribonuclease VII activity
I6G33_RS01975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G33_RS01975	COG0519	Catalyzes the synthesis of GMP from XMP
I6G33_RS01980	COG0582	viral genome integration into host DNA
I6G33_RS02080	COG3206	protein involved in exopolysaccharide biosynthesis
I6G33_RS02080	COG0489	protein tyrosine kinase activity
I6G33_RS02085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G33_RS02090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G33_RS02110	COG0741	lytic transglycosylase activity
I6G33_RS02115	COG0488	(ABC) transporter
I6G33_RS02125	COG0589	response to stress
I6G33_RS02135	COG0121	glutamine amidotransferase
I6G33_RS02155	COG0542	response to heat
I6G33_RS02165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G33_RS02175	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6G33_RS02190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G33_RS02195	COG2274	protein secretion by the type I secretion system
I6G33_RS02215	COG3300	MHYT domain
I6G33_RS02215	COG5001	Diguanylate cyclase
I6G33_RS02225	COG2832	Protein of unknown function (DUF454)
I6G33_RS02240	COG1846	Transcriptional regulator
I6G33_RS02245	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G33_RS02270	COG2354	Protein conserved in bacteria
I6G33_RS02275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G33_RS02280	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6G33_RS02285	COG0778	Nitroreductase
I6G33_RS02300	COG0745	RESPONSE REGULATOR receiver
I6G33_RS02310	COG2350	Protein conserved in bacteria
I6G33_RS02315	COG2917	probably involved in intracellular septation
I6G33_RS02325	COG0613	PHP domain protein
I6G33_RS02330	COG0009	L-threonylcarbamoyladenylate synthase
I6G33_RS02335	COG0180	Tryptophanyl-tRNA synthetase
I6G33_RS02345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G33_RS02350	COG1131	(ABC) transporter
I6G33_RS02375	COG2226	methyltransferase
I6G33_RS02380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G33_RS02385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G33_RS02425	COG0513	Belongs to the DEAD box helicase family
I6G33_RS02440	COG1404	Belongs to the peptidase S8 family
I6G33_RS02440	COG4935	Belongs to the peptidase S8 family
I6G33_RS02450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6G33_RS02460	COG1201	RNA secondary structure unwinding
I6G33_RS02495	COG2133	pyrroloquinoline quinone binding
I6G33_RS02500	COG4993	Dehydrogenase
I6G33_RS02505	COG2996	Protein conserved in bacteria
I6G33_RS02555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G33_RS02565	COG1017	nitric oxide dioxygenase activity
I6G33_RS02565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G33_RS02570	COG0625	glutathione transferase activity
I6G33_RS02595	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6G33_RS02605	COG4991	sh3 domain protein
I6G33_RS02610	COG0776	regulation of translation
I6G33_RS02630	COG1086	Polysaccharide biosynthesis protein
I6G33_RS02635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G33_RS02640	COG1083	cytidylyl-transferase
I6G33_RS02655	COG2089	acid synthase
I6G33_RS02670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G33_RS02675	COG0438	transferase activity, transferring glycosyl groups
I6G33_RS02685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G33_RS02705	COG1295	ribonuclease BN
I6G33_RS02730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6G33_RS02735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G33_RS02750	COG3192	ethanolamine utilization protein
I6G33_RS02755	COG4303	Ethanolamine ammonia lyase large subunit
I6G33_RS02765	COG1546	Belongs to the CinA family
I6G33_RS02770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G33_RS02775	COG2137	regulation of response to DNA damage stimulus
I6G33_RS02785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6G33_RS02790	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6G33_RS02800	COG3148	PFAM DTW domain containing protein
I6G33_RS02805	COG0697	spore germination
I6G33_RS02815	COG0583	DNA-binding transcription factor activity
I6G33_RS02825	COG3012	SEC-C Motif Domain Protein
I6G33_RS02845	COG1199	ATP-dependent helicase activity
I6G33_RS02860	COG0259	pyridoxamine-phosphate oxidase activity
I6G33_RS02870	COG3133	Outer membrane lipoprotein
I6G33_RS02875	COG2111	Na H antiporter
I6G33_RS02875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G33_RS02880	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G33_RS02885	COG0651	ATP synthesis coupled electron transport
I6G33_RS02895	COG2212	antiporter activity
I6G33_RS02900	COG1320	monovalent cation:proton antiporter activity
I6G33_RS02905	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6G33_RS02910	COG0024	Methionine aminopeptidase
I6G33_RS02915	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G33_RS02920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G33_RS02925	COG0528	UMP kinase activity
I6G33_RS02930	COG0233	cytoplasmic translational termination
I6G33_RS02935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G33_RS02945	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6G33_RS02970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G33_RS02975	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G33_RS02980	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G33_RS02985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G33_RS02995	COG0825	malonyl-CoA metabolic process
I6G33_RS03000	COG0037	tRNA processing
I6G33_RS03005	COG0504	CTP synthase activity
I6G33_RS03010	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6G33_RS03025	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6G33_RS03030	COG0583	DNA-binding transcription factor activity
I6G33_RS03035	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6G33_RS03040	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6G33_RS03045	COG1902	pentaerythritol trinitrate reductase activity
I6G33_RS03055	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6G33_RS03060	COG0585	pseudouridine synthase activity
I6G33_RS03065	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6G33_RS03070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6G33_RS03090	COG0494	nUDIX hydrolase
I6G33_RS03100	COG0589	response to stress
I6G33_RS03110	COG0217	transcriptional regulatory protein
I6G33_RS03145	COG0483	inositol monophosphate 1-phosphatase activity
I6G33_RS03160	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS03165	COG0546	phosphoglycolate phosphatase activity
I6G33_RS03170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G33_RS03175	COG0402	S-adenosylhomocysteine deaminase activity
I6G33_RS03210	COG0720	synthase
I6G33_RS03215	COG2056	Na+-H+ antiporter family
I6G33_RS03245	COG2153	protein acetylation
I6G33_RS03250	COG2850	peptidyl-arginine hydroxylation
I6G33_RS03260	COG2915	High frequency lysogenization protein hflD homolog
I6G33_RS03265	COG0482	sulfurtransferase activity
I6G33_RS03290	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6G33_RS03295	COG0542	response to heat
I6G33_RS03300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G33_RS03305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6G33_RS03310	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6G33_RS03315	COG0492	ferredoxin-NADP+ reductase activity
I6G33_RS03325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G33_RS03330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G33_RS03335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G33_RS03340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G33_RS03345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G33_RS03345	COG1648	precorrin-2 dehydrogenase activity
I6G33_RS03375	COG2920	part of a sulfur-relay system
I6G33_RS03380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G33_RS03385	COG0435	Glutathione S-transferase
I6G33_RS03390	COG1238	metal cluster binding
I6G33_RS03405	COG0183	Belongs to the thiolase family
I6G33_RS03410	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS03415	COG0318	PFAM AMP-dependent synthetase and ligase
I6G33_RS03420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G33_RS03430	COG1770	oligopeptidase
I6G33_RS03435	COG1024	Enoyl-CoA hydratase
I6G33_RS03435	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G33_RS03440	COG0183	Belongs to the thiolase family
I6G33_RS03475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G33_RS03505	COG0653	protein targeting
I6G33_RS03525	COG0133	tryptophan synthase activity
I6G33_RS03555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G33_RS03560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G33_RS03565	COG1760	l-serine dehydratase
I6G33_RS03575	COG1115	amino acid carrier protein
I6G33_RS03580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G33_RS03580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G33_RS03620	COG4964	Belongs to the GSP D family
I6G33_RS03645	COG0455	bacterial-type flagellum organization
I6G33_RS03690	COG0297	glycogen (starch) synthase activity
I6G33_RS03710	COG0438	transferase activity, transferring glycosyl groups
I6G33_RS03725	COG0489	protein tyrosine kinase activity
I6G33_RS03725	COG3206	protein involved in exopolysaccharide biosynthesis
I6G33_RS03770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G33_RS03775	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS03785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G33_RS03790	COG0066	3-isopropylmalate dehydratase activity
I6G33_RS03815	COG0135	phosphoribosylanthranilate isomerase activity
I6G33_RS03820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G33_RS03825	COG0285	dihydrofolate synthase activity
I6G33_RS03835	COG1286	toxin biosynthetic process
I6G33_RS03870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G33_RS03900	COG3123	guanosine phosphorylase activity
I6G33_RS03915	COG2009	succinate dehydrogenase
I6G33_RS03920	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G33_RS03925	COG1053	succinate dehydrogenase
I6G33_RS03930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G33_RS03950	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G33_RS03985	COG0326	Molecular chaperone. Has ATPase activity
I6G33_RS03990	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS03995	COG1024	Enoyl-CoA hydratase
I6G33_RS04050	COG0210	DNA helicase
I6G33_RS04055	COG0515	serine threonine protein kinase
I6G33_RS04065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G33_RS04065	COG2146	nitrite reductase [NAD(P)H] activity
I6G33_RS04070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G33_RS04070	COG2146	nitrite reductase [NAD(P)H] activity
I6G33_RS04075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G33_RS04090	COG4221	oxidoreductase activity
I6G33_RS04100	COG0415	Belongs to the DNA photolyase family
I6G33_RS04105	COG0789	Transcriptional regulator
I6G33_RS04110	COG3272	Protein of unknown function (DUF1722)
I6G33_RS04120	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I6G33_RS04125	COG1090	epimerase
I6G33_RS04130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G33_RS04135	COG3300	MHYT domain
I6G33_RS04135	COG5001	Diguanylate cyclase
I6G33_RS04140	COG1366	Belongs to the anti-sigma-factor antagonist family
I6G33_RS04160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G33_RS04165	COG0302	gtp cyclohydrolase
I6G33_RS04185	COG0789	Transcriptional regulator
I6G33_RS04190	COG1025	Belongs to the peptidase M16 family
I6G33_RS04205	COG0784	Response regulator, receiver
I6G33_RS04205	COG2205	protein histidine kinase activity
I6G33_RS04210	COG1271	oxidase subunit
I6G33_RS04215	COG1294	oxidase, subunit
I6G33_RS04235	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G33_RS04235	COG1902	pentaerythritol trinitrate reductase activity
I6G33_RS04260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G33_RS04270	COG0705	Rhomboid family
I6G33_RS04285	COG0308	aminopeptidase N
I6G33_RS04290	COG4447	cellulose binding
I6G33_RS04300	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6G33_RS04310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6G33_RS04315	COG0077	Prephenate dehydratase
I6G33_RS04315	COG1605	Chorismate mutase
I6G33_RS04320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G33_RS04325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G33_RS04330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G33_RS04345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G33_RS04350	COG0625	glutathione transferase activity
I6G33_RS04355	COG0302	gtp cyclohydrolase
I6G33_RS04360	COG2840	Smr protein MutS2
I6G33_RS04390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6G33_RS04400	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6G33_RS04420	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6G33_RS04425	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6G33_RS04440	COG0730	response to heat
I6G33_RS04445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G33_RS04450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G33_RS04485	COG0729	surface antigen
I6G33_RS04490	COG2911	Protein conserved in bacteria
I6G33_RS04495	COG1115	amino acid carrier protein
I6G33_RS04520	COG0392	lysyltransferase activity
I6G33_RS04525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G33_RS04530	COG3568	Endonuclease Exonuclease Phosphatase
I6G33_RS04545	COG0583	DNA-binding transcription factor activity
I6G33_RS04550	COG3384	dioxygenase
I6G33_RS04560	COG3038	cytochrome b561
I6G33_RS04565	COG0739	heme binding
I6G33_RS04590	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G33_RS04595	COG0297	glycogen (starch) synthase activity
I6G33_RS04600	COG1546	Belongs to the CinA family
I6G33_RS04600	COG1058	Belongs to the CinA family
I6G33_RS04605	COG3685	Protein conserved in bacteria
I6G33_RS04640	COG0583	DNA-binding transcription factor activity
I6G33_RS04660	COG1566	PFAM secretion protein HlyD family protein
I6G33_RS04700	COG0840	transmembrane signaling receptor activity
I6G33_RS04735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G33_RS04740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G33_RS04745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G33_RS04750	COG0431	NADPH-dependent FMN reductase
I6G33_RS04755	COG0450	alkyl hydroperoxide reductase
I6G33_RS04775	COG5583	Uncharacterized small protein (DUF2292)
I6G33_RS04780	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G33_RS04790	COG4208	sulfate ABC transporter
I6G33_RS04805	COG0586	Pfam SNARE associated Golgi protein
I6G33_RS04820	COG2205	protein histidine kinase activity
I6G33_RS04830	COG0784	Response regulator, receiver
I6G33_RS04830	COG2205	protein histidine kinase activity
I6G33_RS04835	COG2197	response regulator
I6G33_RS04880	COG0701	Predicted permease
I6G33_RS04885	COG0798	PFAM Bile acid sodium symporter
I6G33_RS04895	COG0431	NADPH-dependent FMN reductase
I6G33_RS04900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G33_RS04910	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G33_RS04915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G33_RS04930	COG5002	protein histidine kinase activity
I6G33_RS04945	COG0535	radical SAM domain protein
I6G33_RS04955	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I6G33_RS04960	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G33_RS04995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6G33_RS05000	COG0167	dihydroorotate dehydrogenase activity
I6G33_RS05005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G33_RS05010	COG0366	Alpha amylase catalytic
I6G33_RS05035	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS05040	COG0604	alcohol dehydrogenase
I6G33_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS05040	COG3321	synthase
I6G33_RS05080	COG0840	transmembrane signaling receptor activity
I6G33_RS05090	COG3278	Belongs to the heme-copper respiratory oxidase family
I6G33_RS05105	COG3278	Belongs to the heme-copper respiratory oxidase family
I6G33_RS05120	COG2010	Cytochrome c
I6G33_RS05150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G33_RS05160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G33_RS05165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G33_RS05180	COG0573	inorganic phosphate transmembrane transporter activity
I6G33_RS05195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G33_RS05200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6G33_RS05205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G33_RS05210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G33_RS05230	COG0587	DNA-directed DNA polymerase activity
I6G33_RS05235	COG0488	(ABC) transporter
I6G33_RS05240	COG1968	undecaprenyl-diphosphatase activity
I6G33_RS05245	COG0840	transmembrane signaling receptor activity
I6G33_RS05260	COG2323	membrane
I6G33_RS05275	COG3706	GGDEF domain
I6G33_RS05285	COG0316	Belongs to the HesB IscA family
I6G33_RS05285	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6G33_RS05315	COG2223	nitrite transmembrane transporter activity
I6G33_RS05320	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G33_RS05335	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G33_RS05355	COG0604	alcohol dehydrogenase
I6G33_RS05360	COG0616	signal peptide processing
I6G33_RS05380	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS05395	COG2816	NAD+ diphosphatase activity
I6G33_RS05405	COG1024	Enoyl-CoA hydratase
I6G33_RS05415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G33_RS05420	COG0328	RNA-DNA hybrid ribonuclease activity
I6G33_RS05435	COG0741	lytic transglycosylase activity
I6G33_RS05435	COG1388	LysM domain
I6G33_RS05455	COG4174	ABC transporter (Permease)
I6G33_RS05460	COG4239	(ABC) transporter, permease
I6G33_RS05465	COG4172	Belongs to the ABC transporter superfamily
I6G33_RS05475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G33_RS05485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G33_RS05490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6G33_RS05500	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G33_RS05505	COG3115	cell septum assembly
I6G33_RS05510	COG1196	nuclear chromosome segregation
I6G33_RS05515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G33_RS05530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G33_RS05530	COG2010	Cytochrome c
I6G33_RS05535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G33_RS05560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G33_RS05570	COG0728	peptidoglycan biosynthetic process
I6G33_RS05575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G33_RS05635	COG0840	transmembrane signaling receptor activity
I6G33_RS05655	COG1131	(ABC) transporter
I6G33_RS05675	COG3284	Transcriptional regulator
I6G33_RS05690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G33_RS05695	COG1063	alcohol dehydrogenase
I6G33_RS05700	COG0022	dehydrogenase e1 component
I6G33_RS05705	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G33_RS05710	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G33_RS05715	COG0095	Lipoate-protein ligase
I6G33_RS05730	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6G33_RS05735	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS05750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G33_RS05755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G33_RS05785	COG0861	Integral membrane protein TerC family
I6G33_RS05815	COG0247	lactate metabolic process
I6G33_RS05815	COG0277	FAD linked oxidase domain protein
I6G33_RS05825	COG2226	methyltransferase
I6G33_RS05835	COG0431	NADPH-dependent FMN reductase
I6G33_RS05890	COG1335	isochorismatase
I6G33_RS05905	COG0066	3-isopropylmalate dehydratase activity
I6G33_RS05910	COG3829	transcription factor binding
I6G33_RS05980	COG4983	Phage plasmid primase, P4 family domain protein
I6G33_RS06005	COG2003	Belongs to the UPF0758 family
I6G33_RS06010	COG1160	GTP binding
I6G33_RS06050	COG1201	RNA secondary structure unwinding
I6G33_RS06075	COG0515	serine threonine protein kinase
I6G33_RS06090	COG0776	regulation of translation
I6G33_RS06095	COG0072	phenylalanine-tRNA ligase activity
I6G33_RS06100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G33_RS06105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G33_RS06110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G33_RS06115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6G33_RS06120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G33_RS06130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G33_RS06205	COG3171	Protein conserved in bacteria
I6G33_RS06210	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G33_RS06215	COG0116	Belongs to the methyltransferase superfamily
I6G33_RS06215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G33_RS06220	COG3130	regulation of translation
I6G33_RS06225	COG0167	dihydroorotate dehydrogenase activity
I6G33_RS06245	COG0714	Associated with various cellular activities
I6G33_RS06275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G33_RS06280	COG3707	response regulator
I6G33_RS06290	COG2223	nitrite transmembrane transporter activity
I6G33_RS06295	COG0515	serine threonine protein kinase
I6G33_RS06295	COG2815	serine threonine protein kinase
I6G33_RS06305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G33_RS06310	COG2146	nitrite reductase [NAD(P)H] activity
I6G33_RS06315	COG0243	molybdopterin cofactor binding
I6G33_RS06325	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G33_RS06330	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G33_RS06350	COG1034	ATP synthesis coupled electron transport
I6G33_RS06360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G33_RS06370	COG0713	ATP synthesis coupled electron transport
I6G33_RS06385	COG1007	ATP synthesis coupled electron transport
I6G33_RS06460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G33_RS06465	COG0215	cysteine-tRNA ligase activity
I6G33_RS06470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G33_RS06475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G33_RS06480	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G33_RS06515	COG0668	transmembrane transport
I6G33_RS06530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G33_RS06540	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G33_RS06555	COG0372	Belongs to the citrate synthase family
I6G33_RS06565	COG1802	Transcriptional regulator
I6G33_RS06590	COG0560	Phosphoserine phosphatase
I6G33_RS06605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G33_RS06610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G33_RS06625	COG1376	ErfK ybiS ycfS ynhG family protein
I6G33_RS06640	COG4181	ATPase activity
I6G33_RS06645	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G33_RS06665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G33_RS06670	COG0084	hydrolase, TatD family'
I6G33_RS06695	COG0714	Associated with various cellular activities
I6G33_RS06710	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6G33_RS06715	COG0709	Synthesizes selenophosphate from selenide and ATP
I6G33_RS06725	COG0628	permease
I6G33_RS06735	COG0596	Alpha beta hydrolase
I6G33_RS06735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G33_RS06760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G33_RS06765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G33_RS06775	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G33_RS06815	COG1024	Enoyl-CoA hydratase
I6G33_RS06840	COG0583	DNA-binding transcription factor activity
I6G33_RS06845	COG2200	EAL domain
I6G33_RS06865	COG0668	transmembrane transport
I6G33_RS06870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G33_RS06880	COG0583	DNA-binding transcription factor activity
I6G33_RS06885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G33_RS06890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G33_RS06905	COG2301	Belongs to the HpcH HpaI aldolase family
I6G33_RS06915	COG2079	MmgE PrpD family protein
I6G33_RS06925	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS06930	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6G33_RS06935	COG0583	DNA-binding transcription factor activity
I6G33_RS06945	COG0477	Major facilitator Superfamily
I6G33_RS06960	COG0840	transmembrane signaling receptor activity
I6G33_RS06965	COG1132	(ABC) transporter
I6G33_RS06970	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G33_RS06975	COG1054	Belongs to the UPF0176 family
I6G33_RS06980	COG0271	Belongs to the BolA IbaG family
I6G33_RS06990	COG0114	fumarate hydratase activity
I6G33_RS06995	COG0183	Belongs to the thiolase family
I6G33_RS07005	COG2977	Belongs to the P-Pant transferase superfamily
I6G33_RS07010	COG2205	protein histidine kinase activity
I6G33_RS07015	COG0745	RESPONSE REGULATOR receiver
I6G33_RS07025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G33_RS07040	COG1943	Transposase
I6G33_RS07045	COG0583	DNA-binding transcription factor activity
I6G33_RS07050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6G33_RS07065	COG2226	methyltransferase
I6G33_RS07090	COG0826	peptidase U32
I6G33_RS07100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G33_RS07115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G33_RS07140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G33_RS07155	COG0800	Aldolase
I6G33_RS07185	COG0395	ABC-type sugar transport system, permease component
I6G33_RS07190	COG1175	transmembrane transport
I6G33_RS07220	COG2937	Belongs to the GPAT DAPAT family
I6G33_RS07225	COG1304	FMN binding
I6G33_RS07230	COG0028	Belongs to the TPP enzyme family
I6G33_RS07235	COG3573	Dehydrogenase
I6G33_RS07255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G33_RS07270	COG0642	Histidine kinase
I6G33_RS07310	COG2132	Multicopper oxidase
I6G33_RS07330	COG2943	transferase activity, transferring hexosyl groups
I6G33_RS07360	COG1346	cytolysis
I6G33_RS07380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G33_RS07405	COG1309	transcriptional regulator
I6G33_RS07410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G33_RS07415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G33_RS07425	COG0742	ribosomal rna small subunit methyltransferase
I6G33_RS07450	COG0563	adenylate kinase activity
I6G33_RS07455	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6G33_RS07495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G33_RS07505	COG2979	Protein of unknown function (DUF533)
I6G33_RS07510	COG1902	pentaerythritol trinitrate reductase activity
I6G33_RS07515	COG3383	formate dehydrogenase (NAD+) activity
I6G33_RS07520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G33_RS07540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G33_RS07550	COG3842	ATPase activity
I6G33_RS07555	COG0590	tRNA wobble adenosine to inosine editing
I6G33_RS07560	COG2132	Multicopper oxidase
I6G33_RS07625	COG3135	benzoate transporter
I6G33_RS07630	COG3485	protocatechuate 3,4-dioxygenase
I6G33_RS07635	COG4829	muconolactone delta-isomerase
I6G33_RS07640	COG4948	Mandelate Racemase Muconate Lactonizing
I6G33_RS07645	COG2814	Major facilitator Superfamily
I6G33_RS07685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G33_RS07700	COG0583	DNA-binding transcription factor activity
I6G33_RS07705	COG0277	FAD linked oxidase domain protein
I6G33_RS07705	COG0247	lactate metabolic process
I6G33_RS07710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G33_RS07715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G33_RS07725	COG0745	RESPONSE REGULATOR receiver
I6G33_RS07735	COG2853	Lipoprotein
I6G33_RS07750	COG0842	Transport permease protein
I6G33_RS07755	COG1131	(ABC) transporter
I6G33_RS07760	COG0739	heme binding
I6G33_RS07770	COG0668	transmembrane transport
I6G33_RS07775	COG4774	siderophore transport
I6G33_RS07785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G33_RS07790	COG1064	alcohol dehydrogenase
I6G33_RS07795	COG2356	endonuclease I
I6G33_RS07800	COG3647	Membrane
I6G33_RS07815	COG0436	Aminotransferase
I6G33_RS07820	COG1160	GTP binding
I6G33_RS07830	COG2976	Protein conserved in bacteria
I6G33_RS07835	COG0124	histidyl-tRNA synthetase
I6G33_RS07840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6G33_RS07845	COG1426	Protein conserved in bacteria
I6G33_RS07855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G33_RS07860	COG0105	UTP biosynthetic process
I6G33_RS07875	COG0443	Heat shock 70 kDa protein
I6G33_RS07880	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G33_RS07885	COG0316	Belongs to the HesB IscA family
I6G33_RS07895	COG1104	cysteine desulfurase activity
I6G33_RS07905	COG1045	serine acetyltransferase
I6G33_RS07920	COG3134	Outer membrane lipoprotein
I6G33_RS07935	COG1862	Preprotein translocase
I6G33_RS07945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G33_RS07955	COG1278	Cold shock
I6G33_RS07965	COG0795	lipopolysaccharide-transporting ATPase activity
I6G33_RS07970	COG0795	lipopolysaccharide-transporting ATPase activity
I6G33_RS07975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G33_RS07995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G33_RS08005	COG0471	metal ion transport
I6G33_RS08005	COG0490	domain, Protein
I6G33_RS08010	COG0477	Major facilitator Superfamily
I6G33_RS08015	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6G33_RS08030	COG3081	Nucleoid-associated protein
I6G33_RS08035	COG2326	polyphosphate kinase activity
I6G33_RS08055	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G33_RS08060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G33_RS08070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G33_RS08075	COG0583	DNA-binding transcription factor activity
I6G33_RS08080	COG0656	L-ascorbic acid biosynthetic process
I6G33_RS08090	COG1280	lysine exporter protein (LysE YggA)
I6G33_RS08095	COG2197	response regulator
I6G33_RS08110	COG1462	curli production assembly transport component CsgG
I6G33_RS08125	COG1309	transcriptional regulator
I6G33_RS08130	COG4067	protein conserved in archaea
I6G33_RS08130	COG0189	ligase activity
I6G33_RS08140	COG0116	Belongs to the methyltransferase superfamily
I6G33_RS08140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G33_RS08150	COG4771	TonB-dependent receptor
I6G33_RS08155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G33_RS08160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G33_RS08165	COG1120	ATPase activity
I6G33_RS08175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G33_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS08190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G33_RS08195	COG1535	isochorismatase
I6G33_RS08195	COG3433	isochorismatase activity
I6G33_RS08200	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6G33_RS08205	COG1169	isochorismate synthase
I6G33_RS08215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G33_RS08220	COG0628	permease
I6G33_RS08230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G33_RS08235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G33_RS08250	COG0436	Aminotransferase
I6G33_RS08270	COG1393	Belongs to the ArsC family
I6G33_RS08280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G33_RS08295	COG3258	Cytochrome c
I6G33_RS08300	COG2863	cytochrome
I6G33_RS08310	COG3530	Putative quorum-sensing-regulated virulence factor
I6G33_RS08325	COG3706	GGDEF domain
I6G33_RS08340	COG1253	flavin adenine dinucleotide binding
I6G33_RS08345	COG1301	dicarboxylic acid transport
I6G33_RS08355	COG0840	transmembrane signaling receptor activity
I6G33_RS08360	COG2814	Major facilitator Superfamily
I6G33_RS08385	COG0251	oxidation-reduction process
I6G33_RS08395	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6G33_RS08405	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6G33_RS08415	COG1492	cobalamin metabolic process
I6G33_RS08425	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6G33_RS08430	COG0778	Nitroreductase
I6G33_RS08435	COG1797	cobyrinic acid a,c-diamide synthase activity
I6G33_RS08450	COG4206	TonB-dependent receptor
I6G33_RS08460	COG0791	NLP P60 protein
I6G33_RS08465	COG0791	NLP P60 protein
I6G33_RS08475	COG4890	Cyd operon protein YbgT
I6G33_RS08480	COG1294	oxidase, subunit
I6G33_RS08510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G33_RS08525	COG1234	tRNA 3'-trailer cleavage
I6G33_RS08550	COG1643	Atp-dependent helicase
I6G33_RS08565	COG0318	PFAM AMP-dependent synthetase and ligase
I6G33_RS08575	COG2030	dehydratase
I6G33_RS08595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G33_RS08605	COG0443	Heat shock 70 kDa protein
I6G33_RS08610	COG2271	Major facilitator Superfamily
I6G33_RS08615	COG3622	Belongs to the hyi family
I6G33_RS08620	COG2084	Dehydrogenase
I6G33_RS08625	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6G33_RS08635	COG3639	organic phosphonate transmembrane transporter activity
I6G33_RS08675	COG0717	Belongs to the dCTP deaminase family
I6G33_RS08680	COG1278	Cold shock
I6G33_RS08685	COG0489	protein tyrosine kinase activity
I6G33_RS08690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G33_RS08690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G33_RS08710	COG2135	peptidase activity
I6G33_RS08730	COG3179	chitinase
I6G33_RS08855	COG0616	signal peptide processing
I6G33_RS08910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G33_RS08920	COG4197	protein conserved in bacteria, prophage-related
I6G33_RS08980	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6G33_RS09020	COG0582	viral genome integration into host DNA
I6G33_RS09095	COG2003	Belongs to the UPF0758 family
I6G33_RS09390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G33_RS09435	COG1192	Involved in chromosome partitioning
I6G33_RS09450	COG0583	DNA-binding transcription factor activity
I6G33_RS09470	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G33_RS09475	COG0542	response to heat
I6G33_RS09485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G33_RS09510	COG0501	Belongs to the peptidase M48B family
I6G33_RS09515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G33_RS09520	COG0583	DNA-binding transcription factor activity
I6G33_RS09530	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6G33_RS09605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G33_RS09610	COG0183	Belongs to the thiolase family
I6G33_RS09615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G33_RS09620	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G33_RS09625	COG1414	Transcriptional regulator
I6G33_RS09650	COG1802	Transcriptional regulator
I6G33_RS09655	COG2252	PERMEase
I6G33_RS09675	COG3195	allantoin biosynthetic process
I6G33_RS09675	COG3648	Uricase
I6G33_RS09680	COG4266	Belongs to the allantoicase family
I6G33_RS09685	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6G33_RS09695	COG2233	PERMEase
I6G33_RS09700	COG4651	solute:proton antiporter activity
I6G33_RS09700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G33_RS09710	COG0840	transmembrane signaling receptor activity
I6G33_RS09745	COG2226	methyltransferase
I6G33_RS09750	COG0500	methyltransferase
I6G33_RS09755	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G33_RS09760	COG1381	Involved in DNA repair and RecF pathway recombination
I6G33_RS09770	COG0571	ribonuclease III activity
I6G33_RS09790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G33_RS09795	COG3086	response to oxidative stress
I6G33_RS09840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G33_RS09850	COG1024	Enoyl-CoA hydratase
I6G33_RS09860	COG4657	Part of a membrane complex involved in electron transport
I6G33_RS09865	COG2878	Part of a membrane complex involved in electron transport
I6G33_RS09875	COG4658	electron transport chain
I6G33_RS09880	COG4659	FMN binding
I6G33_RS09890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G33_RS09900	COG0346	lactoylglutathione lyase activity
I6G33_RS09905	COG0137	argininosuccinate synthase activity
I6G33_RS09915	COG0418	dihydroorotase activity
I6G33_RS09920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G33_RS09935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G33_RS09940	COG4974	Belongs to the 'phage' integrase family
I6G33_RS09950	COG0336	Belongs to the RNA methyltransferase TrmD family
I6G33_RS09955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G33_RS09960	COG0228	four-way junction DNA binding
I6G33_RS09965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G33_RS09970	COG4137	Cytochrome C assembly protein
I6G33_RS09975	COG4536	flavin adenine dinucleotide binding
I6G33_RS09980	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6G33_RS10005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G33_RS10020	COG1126	abc transporter atp-binding protein
I6G33_RS10025	COG0765	amino acid transport
I6G33_RS10030	COG4597	amino acid ABC transporter
I6G33_RS10035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G33_RS10040	COG0400	carboxylic ester hydrolase activity
I6G33_RS10045	COG3706	GGDEF domain
I6G33_RS10065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G33_RS10070	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G33_RS10075	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6G33_RS10085	COG3022	response to hydroperoxide
I6G33_RS10100	COG0433	COG0433 Predicted ATPase
I6G33_RS10110	COG0788	formyltetrahydrofolate deformylase activity
I6G33_RS10120	COG2925	Exonuclease
I6G33_RS10140	COG0714	Associated with various cellular activities
I6G33_RS10185	COG4628	conserved protein (DUF2132)
I6G33_RS10190	COG0693	protein deglycase activity
I6G33_RS10195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G33_RS10235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G33_RS10250	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I6G33_RS10260	COG1309	transcriptional regulator
I6G33_RS10265	COG0386	Belongs to the glutathione peroxidase family
I6G33_RS10275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G33_RS10285	COG0204	Acyl-transferase
I6G33_RS10300	COG2885	chlorophyll binding
I6G33_RS10305	COG3048	D-serine ammonia-lyase activity
I6G33_RS10310	COG0318	PFAM AMP-dependent synthetase and ligase
I6G33_RS10315	COG1280	lysine exporter protein (LysE YggA)
I6G33_RS10320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G33_RS10325	COG2813	Specifically methylates the guanine in position
I6G33_RS10330	COG2119	membrane
I6G33_RS10340	COG0501	Belongs to the peptidase M48B family
I6G33_RS10390	COG0659	secondary active sulfate transmembrane transporter activity
I6G33_RS10395	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS10410	COG1285	pathogenesis
I6G33_RS10435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G33_RS10450	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G33_RS10455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G33_RS10460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G33_RS10465	COG0772	Belongs to the SEDS family
I6G33_RS10470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G33_RS10475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G33_RS10480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G33_RS10485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G33_RS10500	COG0275	rRNA processing
I6G33_RS10525	COG0792	nuclease activity
I6G33_RS10530	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G33_RS10535	COG2823	Periplasmic or secreted lipoprotein
I6G33_RS10540	COG2969	positive regulation of protein catabolic process
I6G33_RS10545	COG0625	glutathione transferase activity
I6G33_RS10550	COG2857	Cytochrome c1
I6G33_RS10555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G33_RS10560	COG0723	plastoquinol--plastocyanin reductase activity
I6G33_RS10565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G33_RS10570	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G33_RS10585	COG0237	dephospho-CoA kinase activity
I6G33_RS10590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6G33_RS10630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G33_RS10645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G33_RS10650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G33_RS10675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G33_RS10680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G33_RS10685	COG1127	ABC transporter
I6G33_RS10695	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G33_RS10705	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6G33_RS10710	COG1137	ATPase activity
I6G33_RS10715	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G33_RS10730	COG1660	Displays ATPase and GTPase activities
I6G33_RS10735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G33_RS10740	COG0312	modulator of DNA gyrase
I6G33_RS10750	COG0312	modulator of DNA gyrase
I6G33_RS10755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G33_RS10765	COG1530	ribonuclease E activity
I6G33_RS10770	COG0424	maF-like protein
I6G33_RS10785	COG1792	Involved in formation and maintenance of cell shape
I6G33_RS10790	COG1077	Cell shape determining protein MreB Mrl
I6G33_RS10795	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G33_RS10800	COG0154	amidase activity
I6G33_RS10805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G33_RS10810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G33_RS10820	COG0530	calcium, potassium:sodium antiporter activity
I6G33_RS10835	COG0739	heme binding
I6G33_RS10845	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6G33_RS10860	COG4771	TonB-dependent receptor
I6G33_RS10870	COG3256	nitric oxide reductase
I6G33_RS10875	COG2010	Cytochrome c
I6G33_RS10900	COG3391	amine dehydrogenase activity
I6G33_RS10905	COG2010	Cytochrome c
I6G33_RS10920	COG0714	Associated with various cellular activities
I6G33_RS10925	COG1845	cytochrome c oxidase, subunit III
I6G33_RS10935	COG0535	radical SAM domain protein
I6G33_RS10940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G33_RS10940	COG1648	precorrin-2 dehydrogenase activity
I6G33_RS10960	COG3278	Belongs to the heme-copper respiratory oxidase family
I6G33_RS10970	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS10990	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G33_RS11005	COG4263	nitrous-oxide reductase activity
I6G33_RS11010	COG0348	domain, Protein
I6G33_RS11010	COG3901	Regulator of nitric oxide reductase transcription
I6G33_RS11015	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS11050	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6G33_RS11075	COG2819	hydrolase of the alpha beta superfamily
I6G33_RS11095	COG0733	neurotransmitter:sodium symporter activity
I6G33_RS11100	COG0625	glutathione transferase activity
I6G33_RS11110	COG0733	neurotransmitter:sodium symporter activity
I6G33_RS11125	COG1522	sequence-specific DNA binding
I6G33_RS11155	COG3154	lipid carrier protein
I6G33_RS11160	COG0826	peptidase U32
I6G33_RS11165	COG0826	peptidase U32
I6G33_RS11175	COG3604	Transcriptional regulator
I6G33_RS11180	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6G33_RS11190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G33_RS11200	COG0019	diaminopimelate decarboxylase activity
I6G33_RS11205	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G33_RS11225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G33_RS11255	COG0534	Mate efflux family protein
I6G33_RS11265	COG1166	arginine decarboxylase activity
I6G33_RS11270	COG0023	Translation Initiation Factor
I6G33_RS11275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G33_RS11280	COG4970	Tfp pilus assembly protein FimT
I6G33_RS11310	COG4968	Prepilin-type N-terminal cleavage methylation domain
I6G33_RS11315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G33_RS11320	COG1047	Peptidyl-prolyl cis-trans
I6G33_RS11325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G33_RS11330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G33_RS11335	COG0196	riboflavin kinase activity
I6G33_RS11340	COG0728	peptidoglycan biosynthetic process
I6G33_RS11345	COG0268	Binds directly to 16S ribosomal RNA
I6G33_RS11350	COG3045	CreA protein
I6G33_RS11355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G33_RS11360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6G33_RS11365	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G33_RS11370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G33_RS11375	COG0142	geranyltranstransferase activity
I6G33_RS11385	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G33_RS11390	COG2862	Uncharacterized protein family, UPF0114
I6G33_RS11400	COG1067	ATP-dependent peptidase activity
I6G33_RS11415	COG2010	Cytochrome c
I6G33_RS11420	COG3256	nitric oxide reductase
I6G33_RS11425	COG0714	Associated with various cellular activities
I6G33_RS11435	COG1970	mechanosensitive ion channel activity
I6G33_RS11440	COG2841	Protein conserved in bacteria
I6G33_RS11460	COG2020	methyltransferase activity
I6G33_RS11475	COG1966	Carbon starvation protein
I6G33_RS11480	COG2879	small protein
I6G33_RS11485	COG0523	cobalamin synthesis protein
I6G33_RS11490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6G33_RS11495	COG0488	(ABC) transporter
I6G33_RS11510	COG2813	Specifically methylates the guanine in position
I6G33_RS11515	COG0693	protein deglycase activity
I6G33_RS11520	COG2252	PERMEase
I6G33_RS11525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G33_RS11530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G33_RS11575	COG3642	lipopolysaccharide core region biosynthetic process
I6G33_RS11595	COG1368	sulfuric ester hydrolase activity
I6G33_RS11620	COG0318	PFAM AMP-dependent synthetase and ligase
I6G33_RS11645	COG0642	Histidine kinase
I6G33_RS11655	COG0402	S-adenosylhomocysteine deaminase activity
I6G33_RS11665	COG1607	acyl-coa hydrolase
I6G33_RS11670	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G33_RS11675	COG1278	Cold shock
I6G33_RS11690	COG5001	Diguanylate cyclase
I6G33_RS11690	COG3300	MHYT domain
I6G33_RS11705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G33_RS11715	COG2814	Major facilitator Superfamily
I6G33_RS11720	COG1309	transcriptional regulator
I6G33_RS11725	COG2217	Heavy metal translocating P-type atpase
I6G33_RS11735	COG0840	transmembrane signaling receptor activity
I6G33_RS11760	COG0513	Belongs to the DEAD box helicase family
I6G33_RS11765	COG4206	TonB-dependent receptor
I6G33_RS11770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G33_RS11780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G33_RS11785	COG3577	Aspartyl protease
I6G33_RS11790	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G33_RS11800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G33_RS11805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G33_RS11820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G33_RS11820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G33_RS11835	COG2264	protein methyltransferase activity
I6G33_RS11845	COG0425	Belongs to the sulfur carrier protein TusA family
I6G33_RS11850	COG2391	methyltransferase activity
I6G33_RS11855	COG3118	belongs to the thioredoxin family
I6G33_RS11895	COG0848	biopolymer transport protein
I6G33_RS11900	COG0811	peptide transport
I6G33_RS11905	COG0811	peptide transport
I6G33_RS11915	COG3047	cAMP biosynthetic process
I6G33_RS11920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G33_RS11935	COG2814	Major facilitator Superfamily
I6G33_RS11945	COG0753	catalase activity
I6G33_RS11950	COG0203	ribosomal protein L17
I6G33_RS11955	COG0202	RNA polymerase activity
I6G33_RS11960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G33_RS11965	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G33_RS11970	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G33_RS11975	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G33_RS11985	COG0200	Binds to the 23S rRNA
I6G33_RS11995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G33_RS12005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G33_RS12010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G33_RS12015	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G33_RS12020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G33_RS12025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G33_RS12030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G33_RS12035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G33_RS12040	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G33_RS12045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G33_RS12050	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6G33_RS12055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G33_RS12060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G33_RS12065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G33_RS12070	COG0089	rRNA binding
I6G33_RS12075	COG0088	Forms part of the polypeptide exit tunnel
I6G33_RS12080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G33_RS12085	COG0051	transcription antitermination factor activity, RNA binding
I6G33_RS12090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G33_RS12095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G33_RS12100	COG0049	tRNA binding
I6G33_RS12105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G33_RS12110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G33_RS12115	COG0085	RNA polymerase activity
I6G33_RS12120	COG0222	ribosome binding
I6G33_RS12130	COG0081	regulation of translation
I6G33_RS12155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G33_RS12180	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6G33_RS12185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6G33_RS12185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6G33_RS12215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G33_RS12220	COG0739	heme binding
I6G33_RS12225	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6G33_RS12230	COG0316	Belongs to the HesB IscA family
I6G33_RS12235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G33_RS12240	COG1981	membrane
I6G33_RS12250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G33_RS12255	COG0537	adenosine 5'-monophosphoramidase activity
I6G33_RS12260	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6G33_RS12265	COG1765	OsmC-like protein
I6G33_RS12275	COG0134	indole-3-glycerol-phosphate synthase activity
I6G33_RS12280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G33_RS12285	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G33_RS12300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G33_RS12305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G33_RS12315	COG1177	transmembrane transport
I6G33_RS12320	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G33_RS12330	COG3842	ATPase activity
I6G33_RS12335	COG2197	response regulator
I6G33_RS12355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6G33_RS12360	COG3178	'Phosphotransferase
I6G33_RS12365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6G33_RS12370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G33_RS12380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G33_RS12385	COG2967	ApaG domain
I6G33_RS12390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G33_RS12395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G33_RS12400	COG2766	serine protein kinase
I6G33_RS12405	COG2718	Belongs to the UPF0229 family
I6G33_RS12410	COG2719	SpoVR family
I6G33_RS12415	COG0617	tRNA 3'-terminal CCA addition
I6G33_RS12425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G33_RS12430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6G33_RS12435	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G33_RS12440	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G33_RS12445	COG0358	DNA primase activity
I6G33_RS12450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G33_RS12460	COG0471	metal ion transport
I6G33_RS12460	COG3273	potassium ion transport
I6G33_RS12465	COG2873	o-acetylhomoserine
I6G33_RS12470	COG3118	belongs to the thioredoxin family
I6G33_RS12495	COG0583	DNA-binding transcription factor activity
I6G33_RS12500	COG2814	Major facilitator Superfamily
I6G33_RS12510	COG0493	'glutamate synthase
I6G33_RS12515	COG0067	glutamate synthase
I6G33_RS12515	COG0069	glutamate synthase activity
I6G33_RS12515	COG0070	glutamate synthase
I6G33_RS12525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6G33_RS12530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G33_RS12565	COG0281	malic enzyme
I6G33_RS12575	COG0254	rRNA binding
I6G33_RS12580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G33_RS12585	COG0018	arginyl-trna synthetase
I6G33_RS12600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6G33_RS12615	COG0248	Ppx GppA phosphatase
I6G33_RS12620	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G33_RS12630	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6G33_RS12635	COG2050	protein possibly involved in aromatic compounds catabolism
I6G33_RS12640	COG1671	Belongs to the UPF0178 family
I6G33_RS12645	COG1280	lysine exporter protein (LysE YggA)
I6G33_RS12650	COG0861	Integral membrane protein TerC family
I6G33_RS12660	COG0488	(ABC) transporter
I6G33_RS12680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G33_RS12710	COG3275	phosphorelay sensor kinase activity
I6G33_RS12720	COG0165	Argininosuccinate lyase
I6G33_RS12750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G33_RS12755	COG1965	Belongs to the frataxin family
I6G33_RS12770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6G33_RS12780	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6G33_RS12785	COG1011	Hydrolase
I6G33_RS12795	COG0432	Pfam Uncharacterised protein family UPF0047
I6G33_RS12800	COG0004	ammonium transporteR
I6G33_RS12805	COG0347	Belongs to the P(II) protein family
I6G33_RS12815	COG0606	chelatase, subunit chli
I6G33_RS12820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G33_RS12835	COG1272	protein, Hemolysin III
I6G33_RS12840	COG1454	alcohol dehydrogenase
I6G33_RS12845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G33_RS12850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G33_RS12870	COG3949	Membrane
I6G33_RS12875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G33_RS12885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G33_RS12890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G33_RS12910	COG2003	Belongs to the UPF0758 family
I6G33_RS12915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G33_RS12920	COG0756	dUTP diphosphatase activity
I6G33_RS12930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G33_RS12945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G33_RS12950	COG0708	Exodeoxyribonuclease III
I6G33_RS12960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6G33_RS12965	COG1561	YicC-like family, N-terminal region
I6G33_RS12975	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6G33_RS12980	COG1538	Outer membrane efflux protein
I6G33_RS12985	COG1519	Transferase
I6G33_RS13000	COG0494	nUDIX hydrolase
I6G33_RS13015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G33_RS13020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6G33_RS13040	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G33_RS13045	COG0277	FAD linked oxidase domain protein
I6G33_RS13050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G33_RS13070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G33_RS13085	COG0513	Belongs to the DEAD box helicase family
I6G33_RS13090	COG1289	transmembrane transporter activity
I6G33_RS13095	COG2081	HI0933 family
I6G33_RS13120	COG3615	Tellurite resistance protein tehB
I6G33_RS13120	COG0500	methyltransferase
I6G33_RS13130	COG0191	fructose-bisphosphate aldolase activity
I6G33_RS13145	COG0126	phosphoglycerate kinase activity
I6G33_RS13150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G33_RS13160	COG0583	DNA-binding transcription factor activity
I6G33_RS13165	COG2175	clavaminate synthase activity
I6G33_RS13180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G33_RS13185	COG0842	Transport permease protein
I6G33_RS13190	COG1131	(ABC) transporter
I6G33_RS13195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G33_RS13200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G33_RS13220	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6G33_RS13225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G33_RS13230	COG0513	Belongs to the DEAD box helicase family
I6G33_RS13245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G33_RS13250	COG2353	YceI-like domain
I6G33_RS13255	COG3038	cytochrome b561
I6G33_RS13265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G33_RS13280	COG0643	Histidine kinase
I6G33_RS13280	COG0784	Response regulator, receiver
I6G33_RS13280	COG2198	Histidine kinase
I6G33_RS13320	COG1678	Uncharacterized ACR, COG1678
I6G33_RS13335	COG0540	Belongs to the ATCase OTCase family
I6G33_RS13375	COG1160	GTP binding
I6G33_RS13380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G33_RS13385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G33_RS13385	COG2813	Specifically methylates the guanine in position
I6G33_RS13395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G33_RS13400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G33_RS13415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G33_RS13420	COG2022	thiamine diphosphate biosynthetic process
I6G33_RS13430	COG2363	Small membrane protein
I6G33_RS13435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G33_RS13455	COG2177	Part of the ABC transporter FtsEX involved in
I6G33_RS13460	COG2884	Cell division ATP-binding protein ftsE
I6G33_RS13465	COG0552	protein localization to endoplasmic reticulum
I6G33_RS13470	COG0612	Peptidase, M16
I6G33_RS13475	COG0612	Peptidase, M16
I6G33_RS13480	COG0742	ribosomal rna small subunit methyltransferase
I6G33_RS13490	COG0429	hydrolase of the alpha beta-hydrolase fold
I6G33_RS13495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G33_RS13530	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6G33_RS13535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G33_RS13540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G33_RS13560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G33_RS13565	COG0693	protein deglycase activity
I6G33_RS13570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G33_RS13575	COG2204	response regulator
I6G33_RS13580	COG4191	Histidine kinase
I6G33_RS13585	COG1301	dicarboxylic acid transport
I6G33_RS13590	COG0129	dihydroxy-acid dehydratase activity
I6G33_RS13600	COG2989	Protein conserved in bacteria
I6G33_RS13615	COG1764	response to oxidative stress
I6G33_RS13620	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6G33_RS13650	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS13665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G33_RS13670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G33_RS13685	COG0604	alcohol dehydrogenase
I6G33_RS13720	COG0583	DNA-binding transcription factor activity
I6G33_RS13725	COG1027	Aspartate ammonia-lyase
I6G33_RS13735	COG1115	amino acid carrier protein
I6G33_RS13740	COG0252	asparaginase activity
I6G33_RS13745	COG2205	protein histidine kinase activity
I6G33_RS13750	COG1082	Xylose isomerase domain protein TIM barrel
I6G33_RS13750	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6G33_RS13755	COG0318	PFAM AMP-dependent synthetase and ligase
I6G33_RS13775	COG0511	ligase activity, forming carbon-carbon bonds
I6G33_RS13775	COG5016	pyruvate
I6G33_RS13780	COG0439	Biotin carboxylase
I6G33_RS13785	COG0583	DNA-binding transcription factor activity
I6G33_RS13800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G33_RS13810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G33_RS13815	COG1917	Cupin 2, conserved barrel domain protein
I6G33_RS13820	COG5285	phytanoyl-CoA dioxygenase
I6G33_RS13825	COG0527	aspartate kinase activity
I6G33_RS13830	COG2841	Protein conserved in bacteria
I6G33_RS13835	COG0826	peptidase U32
I6G33_RS13840	COG3675	Pfam Lipase (class 3)
I6G33_RS13865	COG0210	DNA helicase
I6G33_RS13870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6G33_RS13885	COG1764	response to oxidative stress
I6G33_RS13900	COG0437	4 iron, 4 sulfur cluster binding
I6G33_RS13905	COG2864	formate dehydrogenase
I6G33_RS13910	COG3058	Necessary for formate dehydrogenase activity
I6G33_RS13915	COG1921	L-seryl-tRNASec selenium transferase activity
I6G33_RS13920	COG3276	selenocysteine insertion sequence binding
I6G33_RS13985	COG0509	glycine decarboxylation via glycine cleavage system
I6G33_RS13995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G33_RS14005	COG2204	response regulator
I6G33_RS14010	COG0676	glucose-6-phosphate 1-epimerase activity
I6G33_RS14070	COG2204	response regulator
I6G33_RS14120	COG3179	chitinase
I6G33_RS14170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G33_RS14175	COG0583	DNA-binding transcription factor activity
I6G33_RS14180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G33_RS14250	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G33_RS14260	COG2207	Transcriptional regulator
I6G33_RS14330	COG1611	Belongs to the LOG family
I6G33_RS14340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G33_RS14345	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6G33_RS14350	COG0735	belongs to the Fur family
I6G33_RS14355	COG1121	(ABC) transporter
I6G33_RS14360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G33_RS14365	COG1451	nucleotide metabolic process
I6G33_RS14380	COG2011	ABC-type metal ion transport system permease component
I6G33_RS14420	COG1686	Belongs to the peptidase S11 family
I6G33_RS14435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G33_RS14440	COG0408	coproporphyrinogen oxidase activity
I6G33_RS14450	COG0009	L-threonylcarbamoyladenylate synthase
I6G33_RS14455	COG0758	DNA mediated transformation
I6G33_RS14465	COG0242	peptide deformylase activity
I6G33_RS14470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G33_RS14475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G33_RS14480	COG0569	domain protein
I6G33_RS14485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G33_RS14490	COG0765	amino acid transport
I6G33_RS14495	COG0765	amino acid transport
I6G33_RS14500	COG1126	abc transporter atp-binding protein
I6G33_RS14520	COG2818	Glycosylase
I6G33_RS14530	COG0751	glycine-tRNA ligase activity
I6G33_RS14545	COG3706	GGDEF domain
I6G33_RS14560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G33_RS14570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G33_RS14575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G33_RS14580	COG0594	ribonuclease P activity
I6G33_RS14585	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G33_RS14590	COG0706	membrane insertase activity
I6G33_RS14595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G33_RS14600	COG0445	tRNA wobble uridine modification
I6G33_RS14605	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G33_RS14610	COG1192	Involved in chromosome partitioning
I6G33_RS14615	COG1475	DNA binding
I6G33_RS14625	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G33_RS14635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G33_RS14640	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G33_RS14645	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6G33_RS14650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G33_RS14655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G33_RS14660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6G33_RS14665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G33_RS14670	COG1349	DNA-binding transcription factor activity
I6G33_RS14675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G33_RS14680	COG0500	methyltransferase
I6G33_RS14710	COG0583	DNA-binding transcription factor activity
I6G33_RS14730	COG0625	glutathione transferase activity
I6G33_RS14735	COG0159	tryptophan synthase activity
I6G33_RS14755	COG4249	Peptidase C14 caspase catalytic subunit p20
I6G33_RS14760	COG3360	Dodecin
I6G33_RS14765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G33_RS14800	COG0109	protoheme IX farnesyltransferase activity
I6G33_RS14835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G33_RS14840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G33_RS14870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G33_RS14895	COG0523	cobalamin synthesis protein
I6G33_RS14910	COG1595	DNA-templated transcription, initiation
I6G33_RS14940	COG2358	TRAP transporter, solute receptor (TAXI family
I6G33_RS14950	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G33_RS14955	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6G33_RS14960	COG3454	Phosphonate metabolism
I6G33_RS14965	COG4778	phosphonate C-P lyase system protein PhnL
I6G33_RS14970	COG4107	phosphonate C-P lyase system protein PhnK
I6G33_RS14975	COG3627	carbon phosphorus lyase activity
I6G33_RS14980	COG3626	phosphonate metabolism
I6G33_RS14990	COG3624	Phosphonate C-P lyase system protein PhnG
I6G33_RS14995	COG2188	Transcriptional regulator
I6G33_RS15000	COG3639	organic phosphonate transmembrane transporter activity
I6G33_RS15005	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6G33_RS15015	COG4221	oxidoreductase activity
I6G33_RS15025	COG0784	Response regulator, receiver
I6G33_RS15025	COG0835	chemotaxis
I6G33_RS15030	COG3706	GGDEF domain
I6G33_RS15045	COG3909	cytochrome
I6G33_RS15060	COG1024	Enoyl-CoA hydratase
I6G33_RS15060	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G33_RS15065	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS15070	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS15090	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G33_RS15095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G33_RS15100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G33_RS15105	COG1012	belongs to the aldehyde dehydrogenase family
I6G33_RS15125	COG0745	RESPONSE REGULATOR receiver
I6G33_RS15130	COG5002	protein histidine kinase activity
I6G33_RS15140	COG0745	RESPONSE REGULATOR receiver
I6G33_RS15145	COG5002	protein histidine kinase activity
I6G33_RS15150	COG0745	RESPONSE REGULATOR receiver
I6G33_RS15155	COG4191	Histidine kinase
I6G33_RS15160	COG3706	GGDEF domain
I6G33_RS15165	COG2957	Belongs to the agmatine deiminase family
I6G33_RS15175	COG0174	glutamine synthetase
I6G33_RS15180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G33_RS15185	COG0174	glutamine synthetase
I6G33_RS15205	COG3842	ATPase activity
I6G33_RS15210	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G33_RS15215	COG1177	transmembrane transport
I6G33_RS15225	COG1116	anion transmembrane transporter activity
I6G33_RS15240	COG4771	TonB-dependent receptor
I6G33_RS15310	COG0842	Transport permease protein
I6G33_RS15315	COG0842	Transport permease protein
I6G33_RS15315	COG1129	ABC transporter
I6G33_RS15320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G33_RS15335	COG1127	ABC transporter
I6G33_RS15340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G33_RS15370	COG3795	YCII-related domain
I6G33_RS15375	COG4941	Belongs to the sigma-70 factor family
I6G33_RS15390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G33_RS15430	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6G33_RS15435	COG1194	a g-specific adenine glycosylase
I6G33_RS15450	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G33_RS15455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G33_RS15465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6G33_RS15470	COG0107	imidazoleglycerol-phosphate synthase activity
I6G33_RS15480	COG0330	HflC and HflK could
I6G33_RS15490	COG2861	carbohydrate metabolic process
I6G33_RS15495	COG0793	Belongs to the peptidase S41A family
I6G33_RS15500	COG4942	peptidase
I6G33_RS15505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6G33_RS15510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G33_RS15520	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6G33_RS15545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G33_RS15565	COG3079	Belongs to the UPF0149 family
I6G33_RS15570	COG0006	proline dipeptidase activity
I6G33_RS15575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G33_RS15580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G33_RS15590	COG1178	ABC-type Fe3 transport system permease component
I6G33_RS15605	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6G33_RS15630	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G33_RS15635	COG5002	protein histidine kinase activity
I6G33_RS15640	COG2204	response regulator
I6G33_RS15660	COG0700	Nucleoside recognition
I6G33_RS15665	COG3180	Ammonia monooxygenase
I6G33_RS15700	COG0840	transmembrane signaling receptor activity
I6G33_RS15705	COG2358	TRAP transporter, solute receptor (TAXI family
I6G33_RS15720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G33_RS15725	COG1074	ATP-dependent DNA helicase activity
I6G33_RS15730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G33_RS15765	COG0581	inorganic phosphate transmembrane transporter activity
I6G33_RS15770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G33_RS15775	COG0704	Plays a role in the regulation of phosphate uptake
I6G33_RS15780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G33_RS15790	COG2233	PERMEase
I6G33_RS15795	COG0584	glycerophosphoryl diester phosphodiesterase
I6G33_RS15815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G33_RS15825	COG0306	phosphate transporter
I6G33_RS15830	COG1392	Phosphate transport regulator
I6G33_RS15835	COG0306	phosphate transporter
I6G33_RS15850	COG2918	glutathione biosynthetic process
I6G33_RS15860	COG2183	response to ionizing radiation
I6G33_RS15875	COG0189	ligase activity
I6G33_RS15880	COG0189	ligase activity
I6G33_RS15880	COG4067	protein conserved in archaea
I6G33_RS15885	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G33_RS15900	COG0778	Nitroreductase
I6G33_RS15915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G33_RS15920	COG2323	membrane
I6G33_RS15935	COG1024	Enoyl-CoA hydratase
I6G33_RS15935	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G33_RS15940	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS15945	COG1454	alcohol dehydrogenase
I6G33_RS15950	COG0824	Thioesterase
I6G33_RS15960	COG0784	Response regulator, receiver
I6G33_RS15960	COG4191	Histidine kinase
I6G33_RS15965	COG1011	Hydrolase
I6G33_RS15970	COG0494	nUDIX hydrolase
I6G33_RS15975	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6G33_RS15990	COG0058	SHG alpha-glucan phosphorylase activity
I6G33_RS15995	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6G33_RS16020	COG1490	D-aminoacyl-tRNA deacylase activity
I6G33_RS16040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G33_RS16045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G33_RS16050	COG0140	phosphoribosyl-ATP diphosphatase activity
I6G33_RS16055	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G33_RS16060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G33_RS16070	COG2226	methyltransferase
I6G33_RS16085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6G33_RS16110	COG3852	Histidine kinase
I6G33_RS16130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G33_RS16130	COG0301	tRNA thio-modification
I6G33_RS16135	COG1217	gtp-binding protein TYPA
I6G33_RS16155	COG3604	Transcriptional regulator
I6G33_RS16160	COG0426	domain, Protein
I6G33_RS16160	COG1773	rubredoxin
I6G33_RS16170	COG4807	Protein conserved in bacteria
I6G33_RS16175	COG3383	formate dehydrogenase (NAD+) activity
I6G33_RS16215	COG2197	response regulator
I6G33_RS16235	COG0840	transmembrane signaling receptor activity
I6G33_RS16280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G33_RS16295	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6G33_RS16300	COG1196	nuclear chromosome segregation
I6G33_RS16300	COG3264	Mechanosensitive ion channel
I6G33_RS16305	COG3263	regulation of cellular component size
I6G33_RS16310	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS16320	COG2070	2-Nitropropane dioxygenase
I6G33_RS16325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G33_RS16335	COG1040	competence protein
I6G33_RS16340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G33_RS16345	COG0156	8-amino-7-oxononanoate synthase activity
I6G33_RS16350	COG2226	methyltransferase
I6G33_RS16350	COG1073	alpha beta
I6G33_RS16370	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS16375	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS16380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G33_RS16405	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G33_RS16415	COG0859	PFAM glycosyl transferase family 9
I6G33_RS16420	COG0859	PFAM glycosyl transferase family 9
I6G33_RS16425	COG0438	transferase activity, transferring glycosyl groups
I6G33_RS16450	COG2192	nodulation
I6G33_RS16460	COG1086	Polysaccharide biosynthesis protein
I6G33_RS16485	COG1132	(ABC) transporter
I6G33_RS16490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G33_RS16490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G33_RS16510	COG0730	response to heat
I6G33_RS16515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G33_RS16520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6G33_RS16530	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G33_RS16550	COG1192	Involved in chromosome partitioning
I6G33_RS16565	COG0739	heme binding
I6G33_RS16570	COG1253	flavin adenine dinucleotide binding
I6G33_RS16585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6G33_RS16595	COG5001	Diguanylate cyclase
I6G33_RS16595	COG4251	negative regulation of phosphorylation
I6G33_RS16595	COG3706	GGDEF domain
I6G33_RS16595	COG2203	Gaf domain
I6G33_RS16600	COG2186	Transcriptional regulator
I6G33_RS16605	COG0277	FAD linked oxidase domain protein
I6G33_RS16610	COG0277	FAD linked oxidase domain protein
I6G33_RS16615	COG0247	lactate metabolic process
I6G33_RS16620	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6G33_RS16625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G33_RS16630	COG1620	l-lactate permease
I6G33_RS16655	COG0583	DNA-binding transcription factor activity
I6G33_RS16660	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS16670	COG1704	LemA family
I6G33_RS16675	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6G33_RS16685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G33_RS16705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G33_RS16710	COG1758	RNA polymerase activity
I6G33_RS16720	COG0494	nUDIX hydrolase
I6G33_RS16730	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G33_RS16735	COG3150	esterase
I6G33_RS16750	COG3577	Aspartyl protease
I6G33_RS16770	COG3830	Belongs to the UPF0237 family
I6G33_RS16770	COG0560	Phosphoserine phosphatase
I6G33_RS16775	COG1063	alcohol dehydrogenase
I6G33_RS16780	COG5002	protein histidine kinase activity
I6G33_RS16780	COG5001	Diguanylate cyclase
I6G33_RS16790	COG0688	phosphatidylethanolamine metabolic process
I6G33_RS16815	COG1162	GTPase activity
I6G33_RS16825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6G33_RS16830	COG0702	epimerase
I6G33_RS16850	COG1346	cytolysis
I6G33_RS16860	COG0586	Pfam SNARE associated Golgi protein
I6G33_RS16865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G33_RS16870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G33_RS16880	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G33_RS16885	COG0768	penicillin binding
I6G33_RS16890	COG0772	Belongs to the SEDS family
I6G33_RS16895	COG2951	lytic endotransglycosylase activity
I6G33_RS16905	COG1686	Belongs to the peptidase S11 family
I6G33_RS16910	COG2921	Belongs to the UPF0250 family
I6G33_RS16915	COG0321	lipoyl(octanoyl) transferase activity
I6G33_RS16920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6G33_RS16930	COG2951	lytic endotransglycosylase activity
I6G33_RS16950	COG0495	leucyl-tRNA aminoacylation
I6G33_RS16965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G33_RS16970	COG4535	Mg2 and Co2 transporter CorC
I6G33_RS16975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G33_RS16980	COG1702	phosphate starvation-inducible protein PhoH
I6G33_RS16985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G33_RS16995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G33_RS17000	COG0352	thiamine-phosphate diphosphorylase activity
I6G33_RS17005	COG0351	phosphomethylpyrimidine kinase
I6G33_RS17005	COG0352	thiamine-phosphate diphosphorylase activity
I6G33_RS17010	COG2205	protein histidine kinase activity
I6G33_RS17010	COG3437	response regulator, receiver
I6G33_RS17010	COG3850	Histidine kinase
I6G33_RS17010	COG4999	Histidine kinase
I6G33_RS17015	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS17025	COG0427	acetyl-CoA hydrolase
I6G33_RS17030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G33_RS17050	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6G33_RS17060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G33_RS17090	COG1522	sequence-specific DNA binding
I6G33_RS17105	COG1643	Atp-dependent helicase
I6G33_RS17115	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS17135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6G33_RS17140	COG0142	geranyltranstransferase activity
I6G33_RS17145	COG1722	exodeoxyribonuclease VII activity
I6G33_RS17150	COG0730	response to heat
I6G33_RS17155	COG5001	Diguanylate cyclase
I6G33_RS17155	COG3300	MHYT domain
I6G33_RS17170	COG3228	Belongs to the MtfA family
I6G33_RS17175	COG1595	DNA-templated transcription, initiation
I6G33_RS17180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G33_RS17200	COG4303	Ethanolamine ammonia lyase large subunit
I6G33_RS17205	COG0531	amino acid
I6G33_RS17215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G33_RS17225	COG5645	(Lipo)protein
I6G33_RS17240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G33_RS17240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G33_RS17245	COG0802	atpase or kinase
I6G33_RS17250	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G33_RS17255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G33_RS17260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G33_RS17265	COG1923	regulation of RNA biosynthetic process
I6G33_RS17270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G33_RS17275	COG0330	HflC and HflK could
I6G33_RS17280	COG0330	HflC and HflK could
I6G33_RS17285	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6G33_RS17290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G33_RS17305	COG0557	exoribonuclease II activity
I6G33_RS17310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G33_RS17320	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G33_RS17325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G33_RS17335	COG0359	binds to the 23S rRNA
I6G33_RS17340	COG0305	Participates in initiation and elongation during chromosome replication
I6G33_RS17345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G33_RS17440	COG2945	thiolester hydrolase activity
I6G33_RS17445	COG0180	Tryptophanyl-tRNA synthetase
I6G33_RS17450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G33_RS17460	COG1515	deoxyribonuclease V activity
I6G33_RS17465	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G33_RS17480	COG0084	hydrolase, TatD family'
I6G33_RS17490	COG2169	Transcriptional regulator
I6G33_RS17490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G33_RS17500	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6G33_RS17505	COG1946	Acyl-CoA thioesterase
I6G33_RS17515	COG2321	neutral zinc metallopeptidase
I6G33_RS17530	COG2197	response regulator
I6G33_RS17535	COG3850	Histidine kinase
I6G33_RS17545	COG2223	nitrite transmembrane transporter activity
I6G33_RS17550	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G33_RS17555	COG1140	nitrate reductase beta subunit
I6G33_RS17560	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G33_RS17565	COG2181	nitrate reductase activity
I6G33_RS17580	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G33_RS17585	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G33_RS17590	COG0303	'Molybdopterin
I6G33_RS17595	COG3038	cytochrome b561
I6G33_RS17605	COG0420	3'-5' exonuclease activity
I6G33_RS17630	COG3212	peptidase
I6G33_RS17665	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6G33_RS17670	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS17675	COG2610	gluconate transmembrane transporter activity
I6G33_RS17705	COG2814	Major facilitator Superfamily
I6G33_RS17725	COG1737	Transcriptional regulator
I6G33_RS17740	COG0800	Aldolase
I6G33_RS17750	COG4989	oxidoreductase activity
I6G33_RS17760	COG0516	GMP reductase activity
I6G33_RS17760	COG0517	IMP dehydrogenase activity
I6G33_RS17770	COG4580	involved in the transport of maltose and maltodextrins
I6G33_RS17795	COG1175	transmembrane transport
I6G33_RS17800	COG3833	ABC-type maltose transport systems, permease component
I6G33_RS17805	COG2909	trisaccharide binding
I6G33_RS17815	COG0366	Alpha amylase catalytic
I6G33_RS17820	COG3842	ATPase activity
I6G33_RS17825	COG1280	lysine exporter protein (LysE YggA)
I6G33_RS17830	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G33_RS17850	COG1715	Restriction endonuclease
I6G33_RS17890	COG4974	Belongs to the 'phage' integrase family
I6G33_RS17960	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G33_RS17995	COG1815	bacterial-type flagellum-dependent cell motility
I6G33_RS18005	COG4221	oxidoreductase activity
I6G33_RS18010	COG3387	PFAM Glycoside hydrolase 15-related
I6G33_RS18045	COG2132	Multicopper oxidase
I6G33_RS18100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G33_RS18100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G33_RS18155	COG0789	Transcriptional regulator
I6G33_RS18205	COG0583	DNA-binding transcription factor activity
I6G33_RS18215	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G33_RS18220	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6G33_RS18230	COG0471	metal ion transport
I6G33_RS18235	COG1929	Belongs to the glycerate kinase type-1 family
I6G33_RS18240	COG2135	peptidase activity
I6G33_RS18295	COG0247	lactate metabolic process
I6G33_RS18300	COG1620	l-lactate permease
I6G33_RS18310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G33_RS18320	COG2914	Belongs to the UPF0125 (RnfH) family
I6G33_RS18335	COG0497	DNA recombination
I6G33_RS18340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G33_RS18345	COG0443	Heat shock 70 kDa protein
I6G33_RS18350	COG0484	heat shock protein binding
I6G33_RS18355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G33_RS18360	COG0505	Belongs to the CarA family
I6G33_RS18395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G33_RS18400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G33_RS18405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G33_RS18410	COG0149	triose-phosphate isomerase activity
I6G33_RS18415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G33_RS18430	COG0779	Required for maturation of 30S ribosomal subunits
I6G33_RS18435	COG2251	uridine kinase activity
I6G33_RS18435	COG0195	Participates in both transcription termination and antitermination
I6G33_RS18440	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G33_RS18445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G33_RS18450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G33_RS18455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G33_RS18460	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G33_RS18485	COG0166	Belongs to the GPI family
I6G33_RS18495	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6G33_RS18500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G33_RS18505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6G33_RS18525	COG4191	Histidine kinase
I6G33_RS18535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G33_RS18540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G33_RS18545	COG0436	Aminotransferase
I6G33_RS18550	COG1489	DNA binding
I6G33_RS18580	COG0138	bifunctional purine biosynthesis protein purh
I6G33_RS18590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G33_RS18600	COG2264	protein methyltransferase activity
I6G33_RS18615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6G33_RS18630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G33_RS18665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G33_RS18675	COG3098	single-species biofilm formation
I6G33_RS18685	COG0028	Belongs to the TPP enzyme family
I6G33_RS18695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G33_RS18700	COG1183	phosphatidylcholine synthase activity
I6G33_RS18740	COG2995	paraquat-inducible protein a
I6G33_RS18745	COG2995	paraquat-inducible protein a
I6G33_RS18750	COG3008	intermembrane lipid transfer
I6G33_RS18770	COG0019	diaminopimelate decarboxylase activity
I6G33_RS18780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G33_RS18790	COG0456	acetyltransferase
I6G33_RS18800	COG1877	trehalose-phosphatase activity
I6G33_RS18805	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6G33_RS18810	COG0288	reversible hydration of carbon dioxide
I6G33_RS18815	COG0697	spore germination
I6G33_RS18825	COG1487	ribonuclease activity
I6G33_RS18840	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6G33_RS18845	COG2259	Doxx family
I6G33_RS18855	COG0789	Transcriptional regulator
I6G33_RS18885	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G33_RS18885	COG1024	Enoyl-CoA hydratase
I6G33_RS18890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G33_RS18895	COG1960	acyl-CoA dehydrogenase activity
I6G33_RS18910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G33_RS18930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G33_RS18935	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6G33_RS18945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6G33_RS18950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G33_RS18960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G33_RS18965	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G33_RS18985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G33_RS18990	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G33_RS19030	COG0653	protein targeting
I6G33_RS19035	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6G33_RS19040	COG0494	nUDIX hydrolase
I6G33_RS19070	COG2096	Adenosyltransferase
I6G33_RS19090	COG1666	GTP binding
I6G33_RS19095	COG0668	transmembrane transport
I6G33_RS19115	COG1028	Short-chain dehydrogenase reductase Sdr
I6G33_RS19155	COG0640	Transcriptional regulator