locus-tag	class	description
UIB01_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UIB01_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
UIB01_RS00030	COG3706	GGDEF domain
UIB01_RS00045	COG0751	glycine-tRNA ligase activity
UIB01_RS00055	COG2818	Glycosylase
UIB01_RS00075	COG1126	abc transporter atp-binding protein
UIB01_RS00080	COG0765	amino acid transport
UIB01_RS00085	COG0765	amino acid transport
UIB01_RS00090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UIB01_RS00095	COG0569	domain protein
UIB01_RS00100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
UIB01_RS00105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
UIB01_RS00110	COG0242	peptide deformylase activity
UIB01_RS00115	COG1652	LysM domain
UIB01_RS00120	COG0758	DNA mediated transformation
UIB01_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
UIB01_RS00135	COG0408	coproporphyrinogen oxidase activity
UIB01_RS00140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UIB01_RS00155	COG1686	Belongs to the peptidase S11 family
UIB01_RS00205	COG0784	Response regulator, receiver
UIB01_RS00205	COG4191	Histidine kinase
UIB01_RS00210	COG0583	DNA-binding transcription factor activity
UIB01_RS00215	COG2323	membrane
UIB01_RS00240	COG1132	(ABC) transporter
UIB01_RS00280	COG0625	glutathione transferase activity
UIB01_RS00285	COG1396	sequence-specific DNA binding
UIB01_RS00290	COG3550	peptidyl-serine autophosphorylation
UIB01_RS00310	COG0159	tryptophan synthase activity
UIB01_RS00315	COG0133	tryptophan synthase activity
UIB01_RS00325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UIB01_RS00345	COG1132	(ABC) transporter
UIB01_RS00350	COG4249	Peptidase C14 caspase catalytic subunit p20
UIB01_RS00355	COG3360	Dodecin
UIB01_RS00365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UIB01_RS00405	COG2358	TRAP transporter, solute receptor (TAXI family
UIB01_RS00420	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
UIB01_RS00425	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
UIB01_RS00430	COG3454	Phosphonate metabolism
UIB01_RS00435	COG4778	phosphonate C-P lyase system protein PhnL
UIB01_RS00440	COG4107	phosphonate C-P lyase system protein PhnK
UIB01_RS00445	COG3627	carbon phosphorus lyase activity
UIB01_RS00450	COG3626	phosphonate metabolism
UIB01_RS00460	COG3624	Phosphonate C-P lyase system protein PhnG
UIB01_RS00465	COG2188	Transcriptional regulator
UIB01_RS00470	COG3639	organic phosphonate transmembrane transporter activity
UIB01_RS00475	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
UIB01_RS00485	COG4221	oxidoreductase activity
UIB01_RS00495	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
UIB01_RS00500	COG3052	prosthetic group binding
UIB01_RS00535	COG0840	transmembrane signaling receptor activity
UIB01_RS00570	COG2204	response regulator
UIB01_RS00630	COG0676	glucose-6-phosphate 1-epimerase activity
UIB01_RS00645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UIB01_RS00655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
UIB01_RS00720	COG0582	viral genome integration into host DNA
UIB01_RS00730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
UIB01_RS00735	COG1194	a g-specific adenine glycosylase
UIB01_RS00750	COG1116	anion transmembrane transporter activity
UIB01_RS00760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UIB01_RS00765	COG3707	response regulator
UIB01_RS00770	COG0131	Imidazoleglycerol-phosphate dehydratase
UIB01_RS00785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
UIB01_RS00790	COG0107	imidazoleglycerol-phosphate synthase activity
UIB01_RS00810	COG0793	Belongs to the peptidase S41A family
UIB01_RS00815	COG4942	peptidase
UIB01_RS00820	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
UIB01_RS00825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UIB01_RS00835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
UIB01_RS00855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
UIB01_RS00870	COG3079	Belongs to the UPF0149 family
UIB01_RS00875	COG0006	proline dipeptidase activity
UIB01_RS00880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UIB01_RS00890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UIB01_RS00900	COG1178	ABC-type Fe3 transport system permease component
UIB01_RS00915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UIB01_RS00915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UIB01_RS00920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
UIB01_RS00945	COG3023	N-Acetylmuramoyl-L-alanine amidase
UIB01_RS00955	COG5002	protein histidine kinase activity
UIB01_RS00960	COG2204	response regulator
UIB01_RS00980	COG0700	Nucleoside recognition
UIB01_RS00990	COG2358	TRAP transporter, solute receptor (TAXI family
UIB01_RS00995	COG2203	Gaf domain
UIB01_RS00995	COG5001	Diguanylate cyclase
UIB01_RS00995	COG3706	GGDEF domain
UIB01_RS00995	COG4251	negative regulation of phosphorylation
UIB01_RS01030	COG3180	Ammonia monooxygenase
UIB01_RS01035	COG1283	sodium-dependent phosphate transmembrane transporter activity
UIB01_RS01045	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
UIB01_RS01050	COG1074	ATP-dependent DNA helicase activity
UIB01_RS01055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UIB01_RS01070	COG5002	protein histidine kinase activity
UIB01_RS01070	COG5001	Diguanylate cyclase
UIB01_RS01070	COG3447	MASE1 domain protein
UIB01_RS01075	COG1607	acyl-coa hydrolase
UIB01_RS01090	COG0573	inorganic phosphate transmembrane transporter activity
UIB01_RS01095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UIB01_RS01100	COG0704	Plays a role in the regulation of phosphate uptake
UIB01_RS01115	COG1160	GTP binding
UIB01_RS01125	COG0584	glycerophosphoryl diester phosphodiesterase
UIB01_RS01155	COG0129	dihydroxy-acid dehydratase activity
UIB01_RS01170	COG0693	protein deglycase activity
UIB01_RS01180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UIB01_RS01200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
UIB01_RS01205	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UIB01_RS01210	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
UIB01_RS01230	COG0429	hydrolase of the alpha beta-hydrolase fold
UIB01_RS01240	COG0742	ribosomal rna small subunit methyltransferase
UIB01_RS01245	COG0612	Peptidase, M16
UIB01_RS01250	COG0612	Peptidase, M16
UIB01_RS01255	COG0552	protein localization to endoplasmic reticulum
UIB01_RS01260	COG2884	Cell division ATP-binding protein ftsE
UIB01_RS01265	COG2177	Part of the ABC transporter FtsEX involved in
UIB01_RS01285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UIB01_RS01290	COG2363	Small membrane protein
UIB01_RS01300	COG2022	thiamine diphosphate biosynthetic process
UIB01_RS01305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UIB01_RS01345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UIB01_RS01360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UIB01_RS01360	COG2813	Specifically methylates the guanine in position
UIB01_RS01365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UIB01_RS01370	COG1160	GTP binding
UIB01_RS01420	COG0540	Belongs to the ATCase OTCase family
UIB01_RS01425	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
UIB01_RS01430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
UIB01_RS01435	COG1678	Uncharacterized ACR, COG1678
UIB01_RS01475	COG2198	Histidine kinase
UIB01_RS01475	COG0784	Response regulator, receiver
UIB01_RS01475	COG0643	Histidine kinase
UIB01_RS01480	COG2201	protein-glutamate methylesterase activity
UIB01_RS01490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UIB01_RS01500	COG3038	cytochrome b561
UIB01_RS01505	COG2353	YceI-like domain
UIB01_RS01510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UIB01_RS01525	COG0513	Belongs to the DEAD box helicase family
UIB01_RS01530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
UIB01_RS01535	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
UIB01_RS01555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UIB01_RS01560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UIB01_RS01565	COG1131	(ABC) transporter
UIB01_RS01570	COG0842	Transport permease protein
UIB01_RS01580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
UIB01_RS01595	COG2175	clavaminate synthase activity
UIB01_RS01600	COG0583	DNA-binding transcription factor activity
UIB01_RS01605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
UIB01_RS01610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UIB01_RS01615	COG0126	phosphoglycerate kinase activity
UIB01_RS01630	COG0191	fructose-bisphosphate aldolase activity
UIB01_RS01670	COG2081	HI0933 family
UIB01_RS01680	COG1289	transmembrane transporter activity
UIB01_RS01685	COG0513	Belongs to the DEAD box helicase family
UIB01_RS01700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UIB01_RS01775	COG0330	HflC and HflK could
UIB01_RS01800	COG2205	protein histidine kinase activity
UIB01_RS01800	COG3437	response regulator, receiver
UIB01_RS01800	COG3850	Histidine kinase
UIB01_RS01800	COG4999	Histidine kinase
UIB01_RS01805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UIB01_RS01815	COG2205	protein histidine kinase activity
UIB01_RS01815	COG0784	Response regulator, receiver
UIB01_RS01820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
UIB01_RS01825	COG3264	Mechanosensitive ion channel
UIB01_RS01825	COG1196	nuclear chromosome segregation
UIB01_RS01830	COG3263	regulation of cellular component size
UIB01_RS01835	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS01845	COG1304	FMN binding
UIB01_RS01880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
UIB01_RS01885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UIB01_RS01890	COG1040	competence protein
UIB01_RS01895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UIB01_RS01900	COG0156	8-amino-7-oxononanoate synthase activity
UIB01_RS01905	COG2226	methyltransferase
UIB01_RS01905	COG1073	alpha beta
UIB01_RS01925	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS01930	COG3706	GGDEF domain
UIB01_RS01935	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS01940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UIB01_RS01965	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
UIB01_RS01975	COG0859	PFAM glycosyl transferase family 9
UIB01_RS01980	COG0859	PFAM glycosyl transferase family 9
UIB01_RS01985	COG0438	transferase activity, transferring glycosyl groups
UIB01_RS02015	COG2192	nodulation
UIB01_RS02020	COG0438	transferase activity, transferring glycosyl groups
UIB01_RS02030	COG3562	capsule polysaccharide
UIB01_RS02055	COG1132	(ABC) transporter
UIB01_RS02070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UIB01_RS02070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
UIB01_RS02080	COG0667	Aldo Keto reductase
UIB01_RS02095	COG1519	Transferase
UIB01_RS02100	COG1538	Outer membrane efflux protein
UIB01_RS02105	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
UIB01_RS02115	COG0494	nUDIX hydrolase
UIB01_RS02125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
UIB01_RS02130	COG3150	esterase
UIB01_RS02170	COG0560	Phosphoserine phosphatase
UIB01_RS02170	COG3830	Belongs to the UPF0237 family
UIB01_RS02175	COG1063	alcohol dehydrogenase
UIB01_RS02190	COG0688	phosphatidylethanolamine metabolic process
UIB01_RS02205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
UIB01_RS02210	COG1360	Flagellar Motor Protein
UIB01_RS02215	COG1162	GTPase activity
UIB01_RS02225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
UIB01_RS02230	COG0702	epimerase
UIB01_RS02250	COG1346	cytolysis
UIB01_RS02260	COG0586	Pfam SNARE associated Golgi protein
UIB01_RS02265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UIB01_RS02270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UIB01_RS02280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
UIB01_RS02285	COG0768	penicillin binding
UIB01_RS02290	COG0772	Belongs to the SEDS family
UIB01_RS02295	COG2951	lytic endotransglycosylase activity
UIB01_RS02305	COG1686	Belongs to the peptidase S11 family
UIB01_RS02310	COG2921	Belongs to the UPF0250 family
UIB01_RS02315	COG0321	lipoyl(octanoyl) transferase activity
UIB01_RS02320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UIB01_RS02330	COG2951	lytic endotransglycosylase activity
UIB01_RS02335	COG3036	rescue of stalled ribosome
UIB01_RS02350	COG0495	leucyl-tRNA aminoacylation
UIB01_RS02365	COG0815	Transfers the fatty acyl group on membrane lipoproteins
UIB01_RS02370	COG4535	Mg2 and Co2 transporter CorC
UIB01_RS02375	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
UIB01_RS02380	COG1702	phosphate starvation-inducible protein PhoH
UIB01_RS02385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UIB01_RS02400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UIB01_RS02405	COG0352	thiamine-phosphate diphosphorylase activity
UIB01_RS02410	COG0351	phosphomethylpyrimidine kinase
UIB01_RS02410	COG0352	thiamine-phosphate diphosphorylase activity
UIB01_RS02415	COG2205	protein histidine kinase activity
UIB01_RS02415	COG3437	response regulator, receiver
UIB01_RS02415	COG3850	Histidine kinase
UIB01_RS02415	COG4999	Histidine kinase
UIB01_RS02420	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS02430	COG0427	acetyl-CoA hydrolase
UIB01_RS02435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UIB01_RS02450	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
UIB01_RS02455	COG0830	nickel cation binding
UIB01_RS02460	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
UIB01_RS02475	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
UIB01_RS02485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UIB01_RS02495	COG1953	Uracil, thiamine, allantoin
UIB01_RS02500	COG0804	urea catabolic process
UIB01_RS02505	COG0832	Belongs to the urease beta subunit family
UIB01_RS02515	COG0831	urea catabolic process
UIB01_RS02520	COG0829	nickel cation binding
UIB01_RS02570	COG1522	sequence-specific DNA binding
UIB01_RS02590	COG1643	Atp-dependent helicase
UIB01_RS02600	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS02620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UIB01_RS02625	COG0142	geranyltranstransferase activity
UIB01_RS02630	COG1722	exodeoxyribonuclease VII activity
UIB01_RS02655	COG3486	L-lysine 6-monooxygenase (NADPH) activity
UIB01_RS02660	COG0076	glutamate decarboxylase activity
UIB01_RS02670	COG5001	Diguanylate cyclase
UIB01_RS02690	COG2135	peptidase activity
UIB01_RS02765	COG3228	Belongs to the MtfA family
UIB01_RS02785	COG4303	Ethanolamine ammonia lyase large subunit
UIB01_RS02790	COG0531	amino acid
UIB01_RS02800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UIB01_RS02825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
UIB01_RS02825	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
UIB01_RS02830	COG0802	atpase or kinase
UIB01_RS02835	COG0860	N-Acetylmuramoyl-L-alanine amidase
UIB01_RS02840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
UIB01_RS02845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
UIB01_RS02850	COG1923	regulation of RNA biosynthetic process
UIB01_RS02855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UIB01_RS02860	COG0330	HflC and HflK could
UIB01_RS02865	COG0330	HflC and HflK could
UIB01_RS02870	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
UIB01_RS02875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
UIB01_RS02890	COG0557	exoribonuclease II activity
UIB01_RS02895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UIB01_RS02905	COG0360	Binds together with S18 to 16S ribosomal RNA
UIB01_RS02910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UIB01_RS02920	COG0359	binds to the 23S rRNA
UIB01_RS02925	COG0305	Participates in initiation and elongation during chromosome replication
UIB01_RS02930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UIB01_RS03010	COG1252	NADH dehydrogenase
UIB01_RS03040	COG2945	thiolester hydrolase activity
UIB01_RS03050	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
UIB01_RS03060	COG1515	deoxyribonuclease V activity
UIB01_RS03065	COG3023	N-Acetylmuramoyl-L-alanine amidase
UIB01_RS03080	COG0084	hydrolase, TatD family'
UIB01_RS03090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UIB01_RS03090	COG2169	Transcriptional regulator
UIB01_RS03100	COG1538	Outer membrane efflux protein
UIB01_RS03105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UIB01_RS03110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UIB01_RS03120	COG0840	transmembrane signaling receptor activity
UIB01_RS03135	COG2217	Heavy metal translocating P-type atpase
UIB01_RS03145	COG1309	transcriptional regulator
UIB01_RS03150	COG2814	Major facilitator Superfamily
UIB01_RS03155	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
UIB01_RS03185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UIB01_RS03190	COG0778	Nitroreductase
UIB01_RS03195	COG0596	Alpha beta hydrolase
UIB01_RS03200	COG0251	oxidation-reduction process
UIB01_RS03205	COG1335	isochorismatase
UIB01_RS03210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UIB01_RS03215	COG1309	transcriptional regulator
UIB01_RS03235	COG1902	pentaerythritol trinitrate reductase activity
UIB01_RS03240	COG0640	Transcriptional regulator
UIB01_RS03250	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UIB01_RS03260	COG0346	lactoylglutathione lyase activity
UIB01_RS03265	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
UIB01_RS03290	COG3300	MHYT domain
UIB01_RS03290	COG5001	Diguanylate cyclase
UIB01_RS03310	COG3845	ABC transporter
UIB01_RS03320	COG1079	Belongs to the binding-protein-dependent transport system permease family
UIB01_RS03340	COG1278	Cold shock
UIB01_RS03345	COG2824	Alkylphosphonate utilization operon protein PhnA
UIB01_RS03350	COG1607	acyl-coa hydrolase
UIB01_RS03360	COG0402	S-adenosylhomocysteine deaminase activity
UIB01_RS03365	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
UIB01_RS03380	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
UIB01_RS03395	COG2154	pterin-4-alpha-carbinolamine dehydratase
UIB01_RS03415	COG1760	l-serine dehydratase
UIB01_RS03420	COG0492	ferredoxin-NADP+ reductase activity
UIB01_RS03450	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS03455	COG0348	domain, Protein
UIB01_RS03455	COG3901	Regulator of nitric oxide reductase transcription
UIB01_RS03460	COG4263	nitrous-oxide reductase activity
UIB01_RS03475	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UIB01_RS03495	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS03505	COG3278	Belongs to the heme-copper respiratory oxidase family
UIB01_RS03525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UIB01_RS03525	COG1648	precorrin-2 dehydrogenase activity
UIB01_RS03530	COG0535	radical SAM domain protein
UIB01_RS03540	COG1845	cytochrome c oxidase, subunit III
UIB01_RS03545	COG0714	Associated with various cellular activities
UIB01_RS03560	COG2010	Cytochrome c
UIB01_RS03565	COG3391	amine dehydrogenase activity
UIB01_RS03590	COG2010	Cytochrome c
UIB01_RS03595	COG3256	nitric oxide reductase
UIB01_RS03620	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
UIB01_RS03625	COG3604	Transcriptional regulator
UIB01_RS03635	COG0826	peptidase U32
UIB01_RS03640	COG0826	peptidase U32
UIB01_RS03645	COG3154	lipid carrier protein
UIB01_RS03650	COG1040	competence protein
UIB01_RS03655	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
UIB01_RS03660	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS03665	COG2610	gluconate transmembrane transporter activity
UIB01_RS03670	COG2031	fatty acid transporter
UIB01_RS03685	COG1522	sequence-specific DNA binding
UIB01_RS03700	COG0733	neurotransmitter:sodium symporter activity
UIB01_RS03710	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
UIB01_RS03720	COG0625	glutathione transferase activity
UIB01_RS03725	COG0733	neurotransmitter:sodium symporter activity
UIB01_RS03745	COG4651	solute:proton antiporter activity
UIB01_RS03745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UIB01_RS03750	COG0513	Belongs to the DEAD box helicase family
UIB01_RS03775	COG0123	including yeast histone deacetylase and acetoin utilization protein
UIB01_RS03785	COG1946	Acyl-CoA thioesterase
UIB01_RS03795	COG2321	neutral zinc metallopeptidase
UIB01_RS03825	COG2197	response regulator
UIB01_RS03830	COG3850	Histidine kinase
UIB01_RS03845	COG2223	nitrite transmembrane transporter activity
UIB01_RS03850	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
UIB01_RS03855	COG1140	nitrate reductase beta subunit
UIB01_RS03860	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
UIB01_RS03865	COG2181	nitrate reductase activity
UIB01_RS03880	COG0521	Mo-molybdopterin cofactor biosynthetic process
UIB01_RS03890	COG3038	cytochrome b561
UIB01_RS03895	COG0642	Histidine kinase
UIB01_RS03955	COG0745	RESPONSE REGULATOR receiver
UIB01_RS03970	COG3642	lipopolysaccharide core region biosynthetic process
UIB01_RS04000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UIB01_RS04005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UIB01_RS04010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UIB01_RS04015	COG2252	PERMEase
UIB01_RS04025	COG3608	succinylglutamate desuccinylase aspartoacylase
UIB01_RS04025	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
UIB01_RS04035	COG2080	2 iron, 2 sulfur cluster binding
UIB01_RS04040	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
UIB01_RS04045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
UIB01_RS04075	COG2813	Specifically methylates the guanine in position
UIB01_RS04110	COG0488	(ABC) transporter
UIB01_RS04115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UIB01_RS04145	COG1970	mechanosensitive ion channel activity
UIB01_RS04155	COG1067	ATP-dependent peptidase activity
UIB01_RS04165	COG2862	Uncharacterized protein family, UPF0114
UIB01_RS04175	COG3046	protein related to deoxyribodipyrimidine photolyase
UIB01_RS04180	COG0545	Peptidyl-prolyl cis-trans isomerase
UIB01_RS04190	COG0142	geranyltranstransferase activity
UIB01_RS04195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UIB01_RS04200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
UIB01_RS04205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UIB01_RS04210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UIB01_RS04215	COG3045	CreA protein
UIB01_RS04220	COG0268	Binds directly to 16S ribosomal RNA
UIB01_RS04225	COG0728	peptidoglycan biosynthetic process
UIB01_RS04230	COG0196	riboflavin kinase activity
UIB01_RS04235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
UIB01_RS04240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
UIB01_RS04245	COG1047	Peptidyl-prolyl cis-trans
UIB01_RS04250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
UIB01_RS04285	COG4968	Prepilin-type N-terminal cleavage methylation domain
UIB01_RS04290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UIB01_RS04295	COG0023	Translation Initiation Factor
UIB01_RS04300	COG1166	arginine decarboxylase activity
UIB01_RS04310	COG0534	Mate efflux family protein
UIB01_RS04320	COG3204	pilus organization
UIB01_RS04340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
UIB01_RS04355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UIB01_RS04355	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
UIB01_RS04360	COG1105	Belongs to the carbohydrate kinase PfkB family
UIB01_RS04365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UIB01_RS04365	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
UIB01_RS04365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UIB01_RS04375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
UIB01_RS04390	COG3128	pkhd-type hydroxylase
UIB01_RS04395	COG4774	siderophore transport
UIB01_RS04400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UIB01_RS04420	COG4771	TonB-dependent receptor
UIB01_RS04435	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
UIB01_RS04445	COG0739	heme binding
UIB01_RS04460	COG0530	calcium, potassium:sodium antiporter activity
UIB01_RS04465	COG0530	calcium, potassium:sodium antiporter activity
UIB01_RS04470	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
UIB01_RS04475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UIB01_RS04480	COG0154	amidase activity
UIB01_RS04490	COG1077	Cell shape determining protein MreB Mrl
UIB01_RS04495	COG1792	Involved in formation and maintenance of cell shape
UIB01_RS04515	COG1530	ribonuclease E activity
UIB01_RS04525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UIB01_RS04530	COG0312	modulator of DNA gyrase
UIB01_RS04540	COG0312	modulator of DNA gyrase
UIB01_RS04550	COG1660	Displays ATPase and GTPase activities
UIB01_RS04565	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
UIB01_RS04570	COG1137	ATPase activity
UIB01_RS04575	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
UIB01_RS04585	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
UIB01_RS04595	COG1127	ABC transporter
UIB01_RS04600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
UIB01_RS04605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
UIB01_RS04630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UIB01_RS04635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
UIB01_RS04640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UIB01_RS04645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UIB01_RS04650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UIB01_RS04660	COG0175	sulfate reduction
UIB01_RS04685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
UIB01_RS04690	COG0237	dephospho-CoA kinase activity
UIB01_RS04705	COG0667	Aldo Keto reductase
UIB01_RS04710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UIB01_RS04715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UIB01_RS04720	COG0723	plastoquinol--plastocyanin reductase activity
UIB01_RS04725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UIB01_RS04730	COG2857	Cytochrome c1
UIB01_RS04735	COG0625	glutathione transferase activity
UIB01_RS04740	COG2969	positive regulation of protein catabolic process
UIB01_RS04745	COG2823	Periplasmic or secreted lipoprotein
UIB01_RS04750	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
UIB01_RS04755	COG0792	nuclease activity
UIB01_RS04775	COG0275	rRNA processing
UIB01_RS04790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UIB01_RS04795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UIB01_RS04800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UIB01_RS04805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UIB01_RS04810	COG0772	Belongs to the SEDS family
UIB01_RS04815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UIB01_RS04820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UIB01_RS04825	COG1181	Belongs to the D-alanine--D-alanine ligase family
UIB01_RS04870	COG1285	pathogenesis
UIB01_RS04895	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS04900	COG0659	secondary active sulfate transmembrane transporter activity
UIB01_RS04955	COG0840	transmembrane signaling receptor activity
UIB01_RS04960	COG0501	Belongs to the peptidase M48B family
UIB01_RS04970	COG2119	membrane
UIB01_RS04975	COG2813	Specifically methylates the guanine in position
UIB01_RS04980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UIB01_RS04985	COG1280	lysine exporter protein (LysE YggA)
UIB01_RS04990	COG0318	PFAM AMP-dependent synthetase and ligase
UIB01_RS04995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UIB01_RS05000	COG2885	chlorophyll binding
UIB01_RS05015	COG0204	Acyl-transferase
UIB01_RS05025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UIB01_RS05035	COG0386	Belongs to the glutathione peroxidase family
UIB01_RS05040	COG1309	transcriptional regulator
UIB01_RS05060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
UIB01_RS05080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
UIB01_RS05085	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
UIB01_RS05095	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
UIB01_RS05100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
UIB01_RS05110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UIB01_RS05115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
UIB01_RS05135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UIB01_RS05140	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
UIB01_RS05180	COG0653	protein targeting
UIB01_RS05185	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
UIB01_RS05195	COG0494	nUDIX hydrolase
UIB01_RS05225	COG2096	Adenosyltransferase
UIB01_RS05240	COG0745	RESPONSE REGULATOR receiver
UIB01_RS05245	COG1666	GTP binding
UIB01_RS05250	COG0668	transmembrane transport
UIB01_RS05270	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS05280	COG3030	protein affecting phage T7 exclusion by the F plasmid
UIB01_RS05285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UIB01_RS05290	COG0459	protein refolding
UIB01_RS05300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UIB01_RS05305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UIB01_RS05335	COG1704	LemA family
UIB01_RS05365	COG0583	DNA-binding transcription factor activity
UIB01_RS05380	COG3240	lipase activity
UIB01_RS05380	COG4625	pathogenesis
UIB01_RS05390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
UIB01_RS05405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UIB01_RS05405	COG1017	nitric oxide dioxygenase activity
UIB01_RS05415	COG0469	pyruvate kinase activity
UIB01_RS05425	COG2084	Dehydrogenase
UIB01_RS05430	COG3622	Belongs to the hyi family
UIB01_RS05435	COG3960	tartronate-semialdehyde synthase activity
UIB01_RS05440	COG0583	DNA-binding transcription factor activity
UIB01_RS05445	COG2351	hydroxyisourate hydrolase activity
UIB01_RS05485	COG2233	PERMEase
UIB01_RS05490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UIB01_RS05490	COG4651	solute:proton antiporter activity
UIB01_RS05500	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
UIB01_RS05505	COG4266	Belongs to the allantoicase family
UIB01_RS05530	COG2252	PERMEase
UIB01_RS05535	COG1802	Transcriptional regulator
UIB01_RS05540	COG0402	S-adenosylhomocysteine deaminase activity
UIB01_RS05580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UIB01_RS05585	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
UIB01_RS05605	COG2326	polyphosphate kinase activity
UIB01_RS05610	COG3081	Nucleoid-associated protein
UIB01_RS05630	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
UIB01_RS05635	COG0477	Major facilitator Superfamily
UIB01_RS05640	COG0490	domain, Protein
UIB01_RS05640	COG0471	metal ion transport
UIB01_RS05670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UIB01_RS05675	COG0795	lipopolysaccharide-transporting ATPase activity
UIB01_RS05680	COG0795	lipopolysaccharide-transporting ATPase activity
UIB01_RS05690	COG1278	Cold shock
UIB01_RS05710	COG1862	Preprotein translocase
UIB01_RS05725	COG3134	Outer membrane lipoprotein
UIB01_RS05750	COG1104	cysteine desulfurase activity
UIB01_RS05760	COG0316	Belongs to the HesB IscA family
UIB01_RS05765	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
UIB01_RS05770	COG0443	Heat shock 70 kDa protein
UIB01_RS05785	COG0105	UTP biosynthetic process
UIB01_RS05790	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UIB01_RS05805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
UIB01_RS05810	COG0124	histidyl-tRNA synthetase
UIB01_RS05815	COG2976	Protein conserved in bacteria
UIB01_RS05825	COG1160	GTP binding
UIB01_RS05835	COG0436	Aminotransferase
UIB01_RS05860	COG3647	Membrane
UIB01_RS05865	COG2356	endonuclease I
UIB01_RS05875	COG1064	alcohol dehydrogenase
UIB01_RS05880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UIB01_RS05895	COG0668	transmembrane transport
UIB01_RS05905	COG0739	heme binding
UIB01_RS05910	COG1570	exodeoxyribonuclease VII activity
UIB01_RS05925	COG0519	Catalyzes the synthesis of GMP from XMP
UIB01_RS05925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UIB01_RS05935	COG0590	tRNA wobble adenosine to inosine editing
UIB01_RS05940	COG3842	ATPase activity
UIB01_RS05950	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
UIB01_RS05970	COG0556	nucleotide-excision repair
UIB01_RS05975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UIB01_RS06010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UIB01_RS06060	COG3639	organic phosphonate transmembrane transporter activity
UIB01_RS06065	COG3639	organic phosphonate transmembrane transporter activity
UIB01_RS06075	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
UIB01_RS06085	COG1968	undecaprenyl-diphosphatase activity
UIB01_RS06090	COG2084	Dehydrogenase
UIB01_RS06095	COG3622	Belongs to the hyi family
UIB01_RS06100	COG2271	Major facilitator Superfamily
UIB01_RS06105	COG0443	Heat shock 70 kDa protein
UIB01_RS06115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UIB01_RS06135	COG2030	dehydratase
UIB01_RS06145	COG0318	PFAM AMP-dependent synthetase and ligase
UIB01_RS06165	COG1643	Atp-dependent helicase
UIB01_RS06180	COG0515	serine threonine protein kinase
UIB01_RS06180	COG2815	serine threonine protein kinase
UIB01_RS06185	COG0631	protein serine/threonine phosphatase activity
UIB01_RS06190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UIB01_RS06195	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
UIB01_RS06200	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
UIB01_RS06220	COG1234	tRNA 3'-trailer cleavage
UIB01_RS06240	COG3795	YCII-related domain
UIB01_RS06255	COG2258	MOSC domain
UIB01_RS06265	COG0537	adenosine 5'-monophosphoramidase activity
UIB01_RS06280	COG1116	anion transmembrane transporter activity
UIB01_RS06285	COG2733	membrane
UIB01_RS06305	COG1279	arginine transmembrane transporter activity
UIB01_RS06330	COG0508	dehydrogenase complex catalyzes the overall conversion of
UIB01_RS06330	COG0596	Alpha beta hydrolase
UIB01_RS06340	COG2814	Major facilitator Superfamily
UIB01_RS06350	COG0490	domain, Protein
UIB01_RS06350	COG0471	metal ion transport
UIB01_RS06365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UIB01_RS06375	COG1301	dicarboxylic acid transport
UIB01_RS06395	COG1079	Belongs to the binding-protein-dependent transport system permease family
UIB01_RS06400	COG4603	Belongs to the binding-protein-dependent transport system permease family
UIB01_RS06405	COG3845	ABC transporter
UIB01_RS06410	COG2207	Transcriptional regulator
UIB01_RS06420	COG4221	oxidoreductase activity
UIB01_RS06430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UIB01_RS06440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UIB01_RS06465	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
UIB01_RS06520	COG3321	synthase
UIB01_RS06520	COG0604	alcohol dehydrogenase
UIB01_RS06530	COG0189	ligase activity
UIB01_RS06530	COG4067	protein conserved in archaea
UIB01_RS06535	COG0583	DNA-binding transcription factor activity
UIB01_RS06540	COG1309	transcriptional regulator
UIB01_RS06560	COG1462	curli production assembly transport component CsgG
UIB01_RS06580	COG1280	lysine exporter protein (LysE YggA)
UIB01_RS06590	COG4221	oxidoreductase activity
UIB01_RS06595	COG0583	DNA-binding transcription factor activity
UIB01_RS06605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UIB01_RS06615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UIB01_RS06620	COG3706	GGDEF domain
UIB01_RS06635	COG3530	Putative quorum-sensing-regulated virulence factor
UIB01_RS06645	COG2863	cytochrome
UIB01_RS06650	COG3258	Cytochrome c
UIB01_RS06660	COG2166	iron-sulfur cluster assembly
UIB01_RS06665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
UIB01_RS06670	COG2171	N-acyltransferase activity
UIB01_RS06675	COG1393	Belongs to the ArsC family
UIB01_RS06690	COG0436	Aminotransferase
UIB01_RS06705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UIB01_RS06710	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UIB01_RS06720	COG0628	permease
UIB01_RS06740	COG1393	Belongs to the ArsC family
UIB01_RS06745	COG1295	ribonuclease BN
UIB01_RS06775	COG0442	prolyl-tRNA aminoacylation
UIB01_RS06790	COG2900	Belongs to the SlyX family
UIB01_RS06800	COG0783	Belongs to the Dps family
UIB01_RS06805	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
UIB01_RS06815	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
UIB01_RS06820	COG0632	four-way junction helicase activity
UIB01_RS06825	COG2255	four-way junction helicase activity
UIB01_RS06830	COG0824	Thioesterase
UIB01_RS06850	COG0823	Involved in the tonB-independent uptake of proteins
UIB01_RS06855	COG2885	chlorophyll binding
UIB01_RS06860	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
UIB01_RS06865	COG0602	queuosine metabolic process
UIB01_RS06870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
UIB01_RS06880	COG0427	acetyl-CoA hydrolase
UIB01_RS06885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
UIB01_RS06895	COG0425	Belongs to the sulfur carrier protein TusA family
UIB01_RS06905	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UIB01_RS06910	COG2716	regulation of RNA biosynthetic process
UIB01_RS06915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UIB01_RS06925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
UIB01_RS06995	COG0417	DNA replication proofreading
UIB01_RS07030	COG3174	membrane
UIB01_RS07035	COG2205	protein histidine kinase activity
UIB01_RS07045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
UIB01_RS07055	COG2814	Major facilitator Superfamily
UIB01_RS07060	COG2974	May be involved in recombination
UIB01_RS07075	COG0545	Peptidyl-prolyl cis-trans isomerase
UIB01_RS07095	COG1914	H( )-stimulated, divalent metal cation uptake system
UIB01_RS07100	COG1984	allophanate hydrolase subunit 2
UIB01_RS07105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
UIB01_RS07110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
UIB01_RS07120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
UIB01_RS07125	COG3383	formate dehydrogenase (NAD+) activity
UIB01_RS07130	COG1902	pentaerythritol trinitrate reductase activity
UIB01_RS07150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UIB01_RS07190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
UIB01_RS07195	COG0563	adenylate kinase activity
UIB01_RS07220	COG0742	ribosomal rna small subunit methyltransferase
UIB01_RS07230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UIB01_RS07240	COG1309	transcriptional regulator
UIB01_RS07260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UIB01_RS07265	COG0348	domain, Protein
UIB01_RS07270	COG1380	Effector of murein hydrolase LrgA
UIB01_RS07275	COG1346	cytolysis
UIB01_RS07285	COG1472	Belongs to the glycosyl hydrolase 3 family
UIB01_RS07335	COG2132	Multicopper oxidase
UIB01_RS07345	COG2217	Heavy metal translocating P-type atpase
UIB01_RS07360	COG0642	Histidine kinase
UIB01_RS07375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UIB01_RS07395	COG2937	Belongs to the GPAT DAPAT family
UIB01_RS07400	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
UIB01_RS07430	COG1131	(ABC) transporter
UIB01_RS07445	COG1278	Cold shock
UIB01_RS07455	COG2226	methyltransferase
UIB01_RS07460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UIB01_RS07465	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
UIB01_RS07505	COG0513	Belongs to the DEAD box helicase family
UIB01_RS07520	COG0583	DNA-binding transcription factor activity
UIB01_RS07540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UIB01_RS07540	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
UIB01_RS07545	COG2205	protein histidine kinase activity
UIB01_RS07545	COG5002	protein histidine kinase activity
UIB01_RS07545	COG0784	Response regulator, receiver
UIB01_RS07550	COG2860	membrane
UIB01_RS07565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UIB01_RS07570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UIB01_RS07575	COG3956	TIGRFAM MazG family protein
UIB01_RS07600	COG1201	RNA secondary structure unwinding
UIB01_RS07605	COG1793	dna ligase
UIB01_RS07620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UIB01_RS07630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
UIB01_RS07645	COG1805	sodium ion transport
UIB01_RS07660	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
UIB01_RS07670	COG1477	protein flavinylation
UIB01_RS07680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UIB01_RS07685	COG0584	glycerophosphoryl diester phosphodiesterase
UIB01_RS07700	COG4591	ABC-type transport system involved in lipoprotein release permease component
UIB01_RS07705	COG1136	(ABC) transporter
UIB01_RS07720	COG2333	competence protein COMEC
UIB01_RS07720	COG0658	competence protein
UIB01_RS07725	COG0811	peptide transport
UIB01_RS07735	COG1663	tetraacyldisaccharide 4'-kinase activity
UIB01_RS07740	COG2835	tetraacyldisaccharide 4'-kinase activity
UIB01_RS07745	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
UIB01_RS07750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UIB01_RS07755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
UIB01_RS07760	COG1530	ribonuclease E activity
UIB01_RS07770	COG0546	phosphoglycolate phosphatase activity
UIB01_RS07775	COG0616	signal peptide processing
UIB01_RS07775	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
UIB01_RS07780	COG0424	maF-like protein
UIB01_RS07790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
UIB01_RS07795	COG0416	fatty acid biosynthetic process
UIB01_RS07810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UIB01_RS07815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UIB01_RS07820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UIB01_RS07825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UIB01_RS07830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UIB01_RS07845	COG0084	hydrolase, TatD family'
UIB01_RS07850	COG1113	amino acid transport
UIB01_RS07910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UIB01_RS07920	COG5001	Diguanylate cyclase
UIB01_RS07920	COG3300	MHYT domain
UIB01_RS07930	COG2130	NADP-dependent
UIB01_RS07935	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS07940	COG3135	benzoate transporter
UIB01_RS07945	COG1677	Flagellar hook-basal body complex protein FliE
UIB01_RS07980	COG0745	RESPONSE REGULATOR receiver
UIB01_RS08020	COG1987	bacterial-type flagellum assembly
UIB01_RS08035	COG2032	superoxide dismutase activity
UIB01_RS08040	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UIB01_RS08065	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
UIB01_RS08070	COG2198	Histidine kinase
UIB01_RS08070	COG0784	Response regulator, receiver
UIB01_RS08070	COG0643	Histidine kinase
UIB01_RS08075	COG2201	protein-glutamate methylesterase activity
UIB01_RS08080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
UIB01_RS08085	COG1360	Flagellar Motor Protein
UIB01_RS08090	COG1192	Involved in chromosome partitioning
UIB01_RS08100	COG0835	chemotaxis
UIB01_RS08115	COG2257	FlhB HrpN YscU SpaS Family
UIB01_RS08145	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
UIB01_RS08190	COG0500	methyltransferase
UIB01_RS08200	COG0501	Belongs to the peptidase M48B family
UIB01_RS08210	COG0436	Aminotransferase
UIB01_RS08215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UIB01_RS08220	COG0386	Belongs to the glutathione peroxidase family
UIB01_RS08275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UIB01_RS08295	COG1136	(ABC) transporter
UIB01_RS08305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UIB01_RS08325	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
UIB01_RS08360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
UIB01_RS08370	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
UIB01_RS08395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UIB01_RS08400	COG0471	metal ion transport
UIB01_RS08405	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
UIB01_RS08415	COG0840	transmembrane signaling receptor activity
UIB01_RS08430	COG3436	PFAM IS66 Orf2 family protein
UIB01_RS08435	COG4372	Transposase
UIB01_RS08440	COG3012	SEC-C Motif Domain Protein
UIB01_RS08450	COG0776	regulation of translation
UIB01_RS08465	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
UIB01_RS08470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
UIB01_RS08490	COG0728	peptidoglycan biosynthetic process
UIB01_RS08500	COG1086	Polysaccharide biosynthesis protein
UIB01_RS08510	COG0438	transferase activity, transferring glycosyl groups
UIB01_RS08515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
UIB01_RS08525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UIB01_RS08550	COG0183	Belongs to the thiolase family
UIB01_RS08590	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
UIB01_RS08595	COG3206	protein involved in exopolysaccharide biosynthesis
UIB01_RS08595	COG0489	protein tyrosine kinase activity
UIB01_RS08600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UIB01_RS08615	COG3437	response regulator, receiver
UIB01_RS08620	COG3217	Mosc domain protein beta barrel domain protein
UIB01_RS08620	COG0633	Ferredoxin
UIB01_RS08625	COG0741	lytic transglycosylase activity
UIB01_RS08630	COG0488	(ABC) transporter
UIB01_RS08640	COG0589	response to stress
UIB01_RS08650	COG0121	glutamine amidotransferase
UIB01_RS08670	COG0542	response to heat
UIB01_RS08680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UIB01_RS08690	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
UIB01_RS08705	COG2832	Protein of unknown function (DUF454)
UIB01_RS08715	COG0514	ATP-dependent DNA helicase (RecQ)
UIB01_RS08725	COG1752	Esterase of the alpha-beta hydrolase superfamily
UIB01_RS08740	COG2207	Transcriptional regulator
UIB01_RS08760	COG2354	Protein conserved in bacteria
UIB01_RS08765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UIB01_RS08770	COG0727	PFAM Uncharacterised protein family (UPF0153)
UIB01_RS08775	COG0778	Nitroreductase
UIB01_RS08780	COG0642	Histidine kinase
UIB01_RS08790	COG0745	RESPONSE REGULATOR receiver
UIB01_RS08800	COG2350	Protein conserved in bacteria
UIB01_RS08805	COG0613	PHP domain protein
UIB01_RS08810	COG0009	L-threonylcarbamoyladenylate synthase
UIB01_RS08815	COG0180	Tryptophanyl-tRNA synthetase
UIB01_RS08825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
UIB01_RS08850	COG1653	transport
UIB01_RS08855	COG1175	transmembrane transport
UIB01_RS08860	COG0395	ABC-type sugar transport system, permease component
UIB01_RS08865	COG3842	ATPase activity
UIB01_RS08885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UIB01_RS08895	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
UIB01_RS08920	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
UIB01_RS08925	COG2308	Evidence 4 Homologs of previously reported genes of
UIB01_RS08935	COG1305	Transglutaminase-like
UIB01_RS08970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UIB01_RS08995	COG0308	aminopeptidase N
UIB01_RS09015	COG0243	molybdopterin cofactor binding
UIB01_RS09020	COG2146	nitrite reductase [NAD(P)H] activity
UIB01_RS09025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UIB01_RS09035	COG0515	serine threonine protein kinase
UIB01_RS09035	COG2815	serine threonine protein kinase
UIB01_RS09040	COG2223	nitrite transmembrane transporter activity
UIB01_RS09055	COG3707	response regulator
UIB01_RS09060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UIB01_RS09090	COG0714	Associated with various cellular activities
UIB01_RS09110	COG0167	dihydroorotate dehydrogenase activity
UIB01_RS09115	COG0116	Belongs to the methyltransferase superfamily
UIB01_RS09115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
UIB01_RS09120	COG2027	D-alanyl-D-alanine carboxypeptidase
UIB01_RS09125	COG3171	Protein conserved in bacteria
UIB01_RS09195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UIB01_RS09205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UIB01_RS09210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UIB01_RS09215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
UIB01_RS09220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UIB01_RS09225	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UIB01_RS09230	COG0072	phenylalanine-tRNA ligase activity
UIB01_RS09235	COG0776	regulation of translation
UIB01_RS09270	COG2948	multi-organism process
UIB01_RS09300	COG3451	type IV secretory pathway VirB4
UIB01_RS09315	COG4962	Type ii secretion system protein e
UIB01_RS09345	COG1429	ligase activity, forming nitrogen-metal bonds
UIB01_RS09350	COG4771	TonB-dependent receptor
UIB01_RS09365	COG0583	DNA-binding transcription factor activity
UIB01_RS09375	COG0367	asparagine synthase
UIB01_RS09390	COG0156	8-amino-7-oxononanoate synthase activity
UIB01_RS09475	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UIB01_RS09520	COG1392	Phosphate transport regulator
UIB01_RS09545	COG2135	peptidase activity
UIB01_RS09550	COG0587	DNA-directed DNA polymerase activity
UIB01_RS09570	COG3755	Protein conserved in bacteria
UIB01_RS09575	COG1132	(ABC) transporter
UIB01_RS09580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
UIB01_RS09585	COG0745	RESPONSE REGULATOR receiver
UIB01_RS09585	COG2205	protein histidine kinase activity
UIB01_RS09585	COG3292	Two component regulator propeller
UIB01_RS09590	COG1335	isochorismatase
UIB01_RS09605	COG1126	abc transporter atp-binding protein
UIB01_RS09610	COG0765	amino acid transport
UIB01_RS09615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UIB01_RS09700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
UIB01_RS09780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UIB01_RS09825	COG0477	Major facilitator Superfamily
UIB01_RS09835	COG0789	Transcriptional regulator
UIB01_RS09850	COG3258	Cytochrome c
UIB01_RS09880	COG3192	ethanolamine utilization protein
UIB01_RS09885	COG4303	Ethanolamine ammonia lyase large subunit
UIB01_RS09890	COG4302	ethanolamine ammonia-lyase activity
UIB01_RS09895	COG3284	Transcriptional regulator
UIB01_RS09900	COG1012	belongs to the aldehyde dehydrogenase family
UIB01_RS09910	COG4772	TonB-dependent receptor
UIB01_RS09915	COG0469	pyruvate kinase activity
UIB01_RS09920	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UIB01_RS09930	COG0252	asparaginase activity
UIB01_RS09935	COG0583	DNA-binding transcription factor activity
UIB01_RS09940	COG1301	dicarboxylic acid transport
UIB01_RS09945	COG0165	Argininosuccinate lyase
UIB01_RS09960	COG2003	Belongs to the UPF0758 family
UIB01_RS09965	COG5489	Protein of unknown function (DUF736)
UIB01_RS10040	COG4245	von Willebrand factor, type A
UIB01_RS10045	COG3039	Transposase
UIB01_RS10050	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
UIB01_RS10060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
UIB01_RS10065	COG0077	Prephenate dehydratase
UIB01_RS10065	COG1605	Chorismate mutase
UIB01_RS10075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
UIB01_RS10080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
UIB01_RS10095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UIB01_RS10100	COG0625	glutathione transferase activity
UIB01_RS10105	COG0302	gtp cyclohydrolase
UIB01_RS10110	COG2840	Smr protein MutS2
UIB01_RS10135	COG0800	Aldolase
UIB01_RS10145	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS10150	COG0546	phosphoglycolate phosphatase activity
UIB01_RS10155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
UIB01_RS10160	COG0402	S-adenosylhomocysteine deaminase activity
UIB01_RS10200	COG2056	Na+-H+ antiporter family
UIB01_RS10205	COG0628	permease
UIB01_RS10230	COG2153	protein acetylation
UIB01_RS10235	COG2850	peptidyl-arginine hydroxylation
UIB01_RS10245	COG2915	High frequency lysogenization protein hflD homolog
UIB01_RS10250	COG0482	sulfurtransferase activity
UIB01_RS10275	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
UIB01_RS10280	COG0542	response to heat
UIB01_RS10285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UIB01_RS10290	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
UIB01_RS10295	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
UIB01_RS10300	COG0492	ferredoxin-NADP+ reductase activity
UIB01_RS10310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
UIB01_RS10315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UIB01_RS10320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UIB01_RS10325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UIB01_RS10330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UIB01_RS10330	COG1648	precorrin-2 dehydrogenase activity
UIB01_RS10350	COG1131	(ABC) transporter
UIB01_RS10370	COG0840	transmembrane signaling receptor activity
UIB01_RS10380	COG3851	Histidine kinase
UIB01_RS10430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UIB01_RS10460	COG4172	Belongs to the ABC transporter superfamily
UIB01_RS10465	COG4239	(ABC) transporter, permease
UIB01_RS10470	COG4174	ABC transporter (Permease)
UIB01_RS10480	COG4166	transmembrane transport
UIB01_RS10490	COG1388	LysM domain
UIB01_RS10490	COG0741	lytic transglycosylase activity
UIB01_RS10495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UIB01_RS10505	COG0328	RNA-DNA hybrid ribonuclease activity
UIB01_RS10520	COG1024	Enoyl-CoA hydratase
UIB01_RS10530	COG2816	NAD+ diphosphatase activity
UIB01_RS10545	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS10565	COG0616	signal peptide processing
UIB01_RS10570	COG0604	alcohol dehydrogenase
UIB01_RS10590	COG0071	Belongs to the small heat shock protein (HSP20) family
UIB01_RS10605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UIB01_RS10610	COG2223	nitrite transmembrane transporter activity
UIB01_RS10645	COG5001	Diguanylate cyclase
UIB01_RS10660	COG0316	Belongs to the HesB IscA family
UIB01_RS10660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
UIB01_RS10665	COG2201	protein-glutamate methylesterase activity
UIB01_RS10670	COG5001	Diguanylate cyclase
UIB01_RS10670	COG3447	MASE1 domain protein
UIB01_RS10670	COG5002	protein histidine kinase activity
UIB01_RS10680	COG2323	membrane
UIB01_RS10695	COG0840	transmembrane signaling receptor activity
UIB01_RS10700	COG1968	undecaprenyl-diphosphatase activity
UIB01_RS10710	COG0488	(ABC) transporter
UIB01_RS10740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
UIB01_RS10745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UIB01_RS10750	COG3265	gluconokinase activity
UIB01_RS10755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UIB01_RS10760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UIB01_RS10765	COG1609	Transcriptional regulator
UIB01_RS10795	COG0729	surface antigen
UIB01_RS10805	COG1115	amino acid carrier protein
UIB01_RS10820	COG0728	peptidoglycan biosynthetic process
UIB01_RS10830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UIB01_RS10870	COG3321	synthase
UIB01_RS10870	COG0604	alcohol dehydrogenase
UIB01_RS10870	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS10875	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS10900	COG0437	4 iron, 4 sulfur cluster binding
UIB01_RS10905	COG2864	formate dehydrogenase
UIB01_RS10920	COG0366	Alpha amylase catalytic
UIB01_RS10925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
UIB01_RS10930	COG0392	lysyltransferase activity
UIB01_RS10935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UIB01_RS10940	COG3568	Endonuclease Exonuclease Phosphatase
UIB01_RS10950	COG0583	DNA-binding transcription factor activity
UIB01_RS10955	COG3384	dioxygenase
UIB01_RS10965	COG0739	heme binding
UIB01_RS10990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
UIB01_RS10995	COG0297	glycogen (starch) synthase activity
UIB01_RS11000	COG1546	Belongs to the CinA family
UIB01_RS11000	COG1058	Belongs to the CinA family
UIB01_RS11005	COG3264	Mechanosensitive ion channel
UIB01_RS11005	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
UIB01_RS11010	COG3685	Protein conserved in bacteria
UIB01_RS11050	COG0583	DNA-binding transcription factor activity
UIB01_RS11095	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
UIB01_RS11100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UIB01_RS11115	COG0022	dehydrogenase e1 component
UIB01_RS11115	COG0508	dehydrogenase complex catalyzes the overall conversion of
UIB01_RS11120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UIB01_RS11125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UIB01_RS11135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UIB01_RS11140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UIB01_RS11145	COG1067	ATP-dependent peptidase activity
UIB01_RS11155	COG0459	protein refolding
UIB01_RS11180	COG0840	transmembrane signaling receptor activity
UIB01_RS11185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UIB01_RS11205	COG5642	Protein of unknown function (DUF2384)
UIB01_RS11220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UIB01_RS11225	COG1742	UPF0060 membrane protein
UIB01_RS11235	COG0431	NADPH-dependent FMN reductase
UIB01_RS11240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UIB01_RS11255	COG2072	flavoprotein involved in K transport
UIB01_RS11260	COG0798	PFAM Bile acid sodium symporter
UIB01_RS11315	COG0784	Response regulator, receiver
UIB01_RS11315	COG2205	protein histidine kinase activity
UIB01_RS11330	COG0535	radical SAM domain protein
UIB01_RS11340	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
UIB01_RS11345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
UIB01_RS11375	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
UIB01_RS11380	COG0167	dihydroorotate dehydrogenase activity
UIB01_RS11385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UIB01_RS11395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UIB01_RS11400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
UIB01_RS11410	COG0544	peptidyl-prolyl cis-trans isomerase activity
UIB01_RS11415	COG0587	DNA-directed DNA polymerase activity
UIB01_RS11440	COG2186	Transcriptional regulator
UIB01_RS11465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UIB01_RS11470	COG0215	cysteine-tRNA ligase activity
UIB01_RS11475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UIB01_RS11480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UIB01_RS11485	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UIB01_RS11520	COG0668	transmembrane transport
UIB01_RS11535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
UIB01_RS11545	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
UIB01_RS11560	COG0372	Belongs to the citrate synthase family
UIB01_RS11570	COG1802	Transcriptional regulator
UIB01_RS11595	COG0560	Phosphoserine phosphatase
UIB01_RS11610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
UIB01_RS11615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
UIB01_RS11650	COG4181	ATPase activity
UIB01_RS11655	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
UIB01_RS11675	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
UIB01_RS11680	COG0084	hydrolase, TatD family'
UIB01_RS11710	COG4770	biotin carboxylase activity
UIB01_RS11725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UIB01_RS11735	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS11755	COG1335	isochorismatase
UIB01_RS11770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UIB01_RS11775	COG1116	anion transmembrane transporter activity
UIB01_RS11780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UIB01_RS11785	COG0174	glutamine synthetase
UIB01_RS11835	COG2920	part of a sulfur-relay system
UIB01_RS11840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UIB01_RS11845	COG0435	Glutathione S-transferase
UIB01_RS11850	COG2205	protein histidine kinase activity
UIB01_RS11850	COG0784	Response regulator, receiver
UIB01_RS11870	COG0789	Transcriptional regulator
UIB01_RS11885	COG0302	gtp cyclohydrolase
UIB01_RS11890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
UIB01_RS11910	COG1366	Belongs to the anti-sigma-factor antagonist family
UIB01_RS11920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
UIB01_RS11925	COG1090	epimerase
UIB01_RS11930	COG3272	Protein of unknown function (DUF1722)
UIB01_RS11935	COG0789	Transcriptional regulator
UIB01_RS11950	COG4221	oxidoreductase activity
UIB01_RS11965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
UIB01_RS11970	COG0840	transmembrane signaling receptor activity
UIB01_RS11985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UIB01_RS11985	COG2146	nitrite reductase [NAD(P)H] activity
UIB01_RS11990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UIB01_RS11990	COG2146	nitrite reductase [NAD(P)H] activity
UIB01_RS11995	COG0210	DNA helicase
UIB01_RS12035	COG5002	protein histidine kinase activity
UIB01_RS12035	COG5001	Diguanylate cyclase
UIB01_RS12035	COG3447	MASE1 domain protein
UIB01_RS12050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UIB01_RS12070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UIB01_RS12075	COG4991	sh3 domain protein
UIB01_RS12090	COG0058	SHG alpha-glucan phosphorylase activity
UIB01_RS12100	COG2205	protein histidine kinase activity
UIB01_RS12115	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
UIB01_RS12125	COG0583	DNA-binding transcription factor activity
UIB01_RS12145	COG1024	Enoyl-CoA hydratase
UIB01_RS12150	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS12160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UIB01_RS12170	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS12175	COG0183	Belongs to the thiolase family
UIB01_RS12190	COG1238	metal cluster binding
UIB01_RS12225	COG0714	Associated with various cellular activities
UIB01_RS12240	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
UIB01_RS12245	COG0709	Synthesizes selenophosphate from selenide and ATP
UIB01_RS12255	COG0628	permease
UIB01_RS12290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UIB01_RS12295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UIB01_RS12310	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS12315	COG0183	Belongs to the thiolase family
UIB01_RS12325	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
UIB01_RS12390	COG0045	succinate-CoA ligase (ADP-forming) activity
UIB01_RS12410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UIB01_RS12415	COG1053	succinate dehydrogenase
UIB01_RS12420	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
UIB01_RS12425	COG2009	succinate dehydrogenase
UIB01_RS12465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UIB01_RS12470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UIB01_RS12475	COG3115	cell septum assembly
UIB01_RS12480	COG1196	nuclear chromosome segregation
UIB01_RS12485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UIB01_RS12490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UIB01_RS12505	COG2010	Cytochrome c
UIB01_RS12505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
UIB01_RS12510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
UIB01_RS12530	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
UIB01_RS12540	COG0840	transmembrane signaling receptor activity
UIB01_RS12550	COG3278	Belongs to the heme-copper respiratory oxidase family
UIB01_RS12560	COG2010	Cytochrome c
UIB01_RS12565	COG3278	Belongs to the heme-copper respiratory oxidase family
UIB01_RS12580	COG2010	Cytochrome c
UIB01_RS12610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
UIB01_RS12620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UIB01_RS12640	COG0573	inorganic phosphate transmembrane transporter activity
UIB01_RS12655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UIB01_RS12660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
UIB01_RS12665	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
UIB01_RS12670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UIB01_RS12700	COG0446	pyridine nucleotide-disulphide oxidoreductase
UIB01_RS12700	COG1902	pentaerythritol trinitrate reductase activity
UIB01_RS12720	COG1294	oxidase, subunit
UIB01_RS12725	COG1271	oxidase subunit
UIB01_RS12750	COG0655	NAD(P)H dehydrogenase (quinone) activity
UIB01_RS12755	COG0583	DNA-binding transcription factor activity
UIB01_RS12770	COG0450	alkyl hydroperoxide reductase
UIB01_RS12780	COG5583	Uncharacterized small protein (DUF2292)
UIB01_RS12785	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
UIB01_RS12795	COG4208	sulfate ABC transporter
UIB01_RS12835	COG1286	toxin biosynthetic process
UIB01_RS12840	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
UIB01_RS12845	COG0285	dihydrofolate synthase activity
UIB01_RS12850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UIB01_RS12855	COG0135	phosphoribosylanthranilate isomerase activity
UIB01_RS12880	COG0473	3-isopropylmalate dehydrogenase activity
UIB01_RS12885	COG0066	3-isopropylmalate dehydratase activity
UIB01_RS12890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UIB01_RS12905	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS12960	COG0250	Participates in transcription elongation, termination and antitermination
UIB01_RS12965	COG0297	glycogen (starch) synthase activity
UIB01_RS12990	COG0297	glycogen (starch) synthase activity
UIB01_RS13005	COG1216	Glycosyl transferase, family 2
UIB01_RS13045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UIB01_RS13050	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
UIB01_RS13055	COG1012	belongs to the aldehyde dehydrogenase family
UIB01_RS13060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
UIB01_RS13065	COG0133	tryptophan synthase activity
UIB01_RS13115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UIB01_RS13150	COG0183	Belongs to the thiolase family
UIB01_RS13155	COG1024	Enoyl-CoA hydratase
UIB01_RS13155	COG1250	3-hydroxyacyl-CoA dehydrogenase
UIB01_RS13160	COG1770	oligopeptidase
UIB01_RS13170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UIB01_RS13180	COG0583	DNA-binding transcription factor activity
UIB01_RS13185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UIB01_RS13190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UIB01_RS13205	COG2301	Belongs to the HpcH HpaI aldolase family
UIB01_RS13215	COG2079	MmgE PrpD family protein
UIB01_RS13225	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS13230	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
UIB01_RS13235	COG0583	DNA-binding transcription factor activity
UIB01_RS13260	COG0840	transmembrane signaling receptor activity
UIB01_RS13275	COG1054	Belongs to the UPF0176 family
UIB01_RS13280	COG0271	Belongs to the BolA IbaG family
UIB01_RS13290	COG0114	fumarate hydratase activity
UIB01_RS13330	COG3135	benzoate transporter
UIB01_RS13335	COG3485	protocatechuate 3,4-dioxygenase
UIB01_RS13340	COG4829	muconolactone delta-isomerase
UIB01_RS13345	COG4948	Mandelate Racemase Muconate Lactonizing
UIB01_RS13385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UIB01_RS13395	COG0745	RESPONSE REGULATOR receiver
UIB01_RS13405	COG2853	Lipoprotein
UIB01_RS13415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UIB01_RS13415	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UIB01_RS13420	COG0842	Transport permease protein
UIB01_RS13425	COG1131	(ABC) transporter
UIB01_RS13430	COG2988	succinylglutamate desuccinylase activity
UIB01_RS13440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UIB01_RS13470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UIB01_RS13475	COG0668	transmembrane transport
UIB01_RS13485	COG2205	protein histidine kinase activity
UIB01_RS13490	COG0745	RESPONSE REGULATOR receiver
UIB01_RS13525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UIB01_RS13530	COG2826	transposase and inactivated derivatives, IS30 family
UIB01_RS13545	COG0583	DNA-binding transcription factor activity
UIB01_RS13550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UIB01_RS13565	COG2226	methyltransferase
UIB01_RS13600	COG2249	NAD(P)H dehydrogenase (quinone) activity
UIB01_RS13605	COG0583	DNA-binding transcription factor activity
UIB01_RS13610	COG1733	regulation of RNA biosynthetic process
UIB01_RS13660	COG3459	Glycosyltransferase 36 associated
UIB01_RS13665	COG0826	peptidase U32
UIB01_RS13675	COG2814	Major facilitator Superfamily
UIB01_RS13680	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS13690	COG2010	Cytochrome c
UIB01_RS13710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UIB01_RS13735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
UIB01_RS13760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UIB01_RS13790	COG0483	inositol monophosphate 1-phosphatase activity
UIB01_RS13805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UIB01_RS13810	COG0004	ammonium transporteR
UIB01_RS13825	COG2258	MOSC domain
UIB01_RS13835	COG0217	transcriptional regulatory protein
UIB01_RS13845	COG0589	response to stress
UIB01_RS13875	COG1051	belongs to the nudix hydrolase family
UIB01_RS13895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UIB01_RS13900	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
UIB01_RS13905	COG0585	pseudouridine synthase activity
UIB01_RS13910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
UIB01_RS13920	COG1902	pentaerythritol trinitrate reductase activity
UIB01_RS13925	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
UIB01_RS13930	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
UIB01_RS13935	COG0583	DNA-binding transcription factor activity
UIB01_RS13950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
UIB01_RS13960	COG0148	phosphopyruvate hydratase activity
UIB01_RS13965	COG2877	3-deoxy-8-phosphooctulonate synthase activity
UIB01_RS13970	COG0504	CTP synthase activity
UIB01_RS13980	COG0825	malonyl-CoA metabolic process
UIB01_RS13990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UIB01_RS13995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UIB01_RS14000	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UIB01_RS14005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UIB01_RS14010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UIB01_RS14020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UIB01_RS14030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UIB01_RS14040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
UIB01_RS14045	COG0233	cytoplasmic translational termination
UIB01_RS14050	COG0528	UMP kinase activity
UIB01_RS14055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
UIB01_RS14060	COG0052	Belongs to the universal ribosomal protein uS2 family
UIB01_RS14065	COG0024	Methionine aminopeptidase
UIB01_RS14070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
UIB01_RS14075	COG1320	monovalent cation:proton antiporter activity
UIB01_RS14080	COG2212	antiporter activity
UIB01_RS14085	COG1863	multisubunit Na H antiporter MnhE subunit
UIB01_RS14090	COG0651	ATP synthesis coupled electron transport
UIB01_RS14095	COG1006	Multisubunit Na H antiporter MnhC subunit
UIB01_RS14100	COG2111	Na H antiporter
UIB01_RS14100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UIB01_RS14115	COG0259	pyridoxamine-phosphate oxidase activity
UIB01_RS14125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UIB01_RS14130	COG1199	ATP-dependent helicase activity
UIB01_RS14150	COG3012	SEC-C Motif Domain Protein
UIB01_RS14160	COG0583	DNA-binding transcription factor activity
UIB01_RS14170	COG0697	spore germination
UIB01_RS14175	COG3148	PFAM DTW domain containing protein
UIB01_RS14185	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
UIB01_RS14190	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
UIB01_RS14200	COG2137	regulation of response to DNA damage stimulus
UIB01_RS14205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UIB01_RS14210	COG1546	Belongs to the CinA family
UIB01_RS14220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
UIB01_RS14225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
UIB01_RS14250	COG1295	ribonuclease BN
UIB01_RS14265	COG2201	protein-glutamate methylesterase activity
UIB01_RS14270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UIB01_RS14275	COG0835	chemotaxis
UIB01_RS14280	COG3290	protein histidine kinase activity
UIB01_RS14280	COG0840	transmembrane signaling receptor activity
UIB01_RS14285	COG2198	Histidine kinase
UIB01_RS14285	COG0643	Histidine kinase
UIB01_RS14295	COG0745	RESPONSE REGULATOR receiver
UIB01_RS14315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UIB01_RS14335	COG3842	ATPase activity
UIB01_RS14355	COG5002	protein histidine kinase activity
UIB01_RS14355	COG0784	Response regulator, receiver
UIB01_RS14355	COG2198	Histidine kinase
UIB01_RS14370	COG1696	Membrane protein involved in D-alanine export
UIB01_RS14380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UIB01_RS14395	COG3284	Transcriptional regulator
UIB01_RS14460	COG2826	transposase and inactivated derivatives, IS30 family
UIB01_RS14500	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
UIB01_RS14515	COG2996	Protein conserved in bacteria
UIB01_RS14520	COG4993	Dehydrogenase
UIB01_RS14525	COG2133	pyrroloquinoline quinone binding
UIB01_RS14560	COG1201	RNA secondary structure unwinding
UIB01_RS14570	COG4221	oxidoreductase activity
UIB01_RS14580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UIB01_RS14590	COG1404	Belongs to the peptidase S8 family
UIB01_RS14590	COG4935	Belongs to the peptidase S8 family
UIB01_RS14600	COG0367	asparagine synthase
UIB01_RS14605	COG0189	ligase activity
UIB01_RS14605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UIB01_RS14610	COG1363	Peptidase, m42
UIB01_RS14620	COG3089	Belongs to the UPF0270 family
UIB01_RS14640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UIB01_RS14645	COG3162	membrane
UIB01_RS14660	COG2853	Lipoprotein
UIB01_RS14670	COG1560	Kdo2-lipid A biosynthetic process
UIB01_RS14675	COG0850	regulation of cytokinetic process
UIB01_RS14680	COG2894	cell division
UIB01_RS14685	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
UIB01_RS14690	COG0564	pseudouridine synthase activity
UIB01_RS14695	COG1362	aminopeptidase activity
UIB01_RS14710	COG2199	diguanylate cyclase activity
UIB01_RS14710	COG2200	EAL domain
UIB01_RS14735	COG1555	photosystem II stabilization
UIB01_RS14745	COG1256	bacterial-type flagellum assembly
UIB01_RS14755	COG1706	bacterial-type flagellum-dependent cell motility
UIB01_RS14760	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
UIB01_RS14765	COG4786	Flagellar basal body rod
UIB01_RS14770	COG4787	bacterial-type flagellum-dependent cell motility
UIB01_RS14775	COG1749	Flagellar hook protein flgE
UIB01_RS14790	COG1815	bacterial-type flagellum-dependent cell motility
UIB01_RS14795	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UIB01_RS14800	COG0784	Response regulator, receiver
UIB01_RS14800	COG0835	chemotaxis
UIB01_RS14820	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
UIB01_RS14845	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
UIB01_RS14850	COG5016	pyruvate
UIB01_RS14850	COG0511	ligase activity, forming carbon-carbon bonds
UIB01_RS14855	COG3630	sodium ion export across plasma membrane
UIB01_RS14860	COG2239	Acts as a magnesium transporter
UIB01_RS14885	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
UIB01_RS14890	COG0527	aspartate kinase activity
UIB01_RS14895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
UIB01_RS14910	COG2983	Belongs to the UPF0260 family
UIB01_RS14920	COG3100	YcgL domain-containing protein
UIB01_RS14935	COG2067	long-chain fatty acid transport protein
UIB01_RS14960	COG0251	oxidation-reduction process
UIB01_RS14970	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
UIB01_RS14980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
UIB01_RS14990	COG1492	cobalamin metabolic process
UIB01_RS15000	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
UIB01_RS15010	COG0778	Nitroreductase
UIB01_RS15015	COG1797	cobyrinic acid a,c-diamide synthase activity
UIB01_RS15030	COG4206	TonB-dependent receptor
UIB01_RS15040	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UIB01_RS15045	COG0791	NLP P60 protein
UIB01_RS15050	COG0791	NLP P60 protein
UIB01_RS15080	COG1294	oxidase, subunit
UIB01_RS15110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
UIB01_RS15115	COG0037	tRNA processing
UIB01_RS15140	COG2814	Major facilitator Superfamily
UIB01_RS15145	COG4459	periplasmic nitrate reductase
UIB01_RS15155	COG0243	molybdopterin cofactor binding
UIB01_RS15160	COG3043	anaerobic respiration
UIB01_RS15165	COG3005	denitrification pathway
UIB01_RS15170	COG0717	Belongs to the dCTP deaminase family
UIB01_RS15175	COG1278	Cold shock
UIB01_RS15180	COG0489	protein tyrosine kinase activity
UIB01_RS15185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UIB01_RS15185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UIB01_RS15200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UIB01_RS15200	COG2755	lipolytic protein G-D-S-L family
UIB01_RS15210	COG3179	chitinase
UIB01_RS15355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UIB01_RS15455	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
UIB01_RS15540	COG3609	addiction module antidote protein, CC2985 family
UIB01_RS15545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UIB01_RS15555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UIB01_RS15560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
UIB01_RS15565	COG1414	Transcriptional regulator
UIB01_RS15575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UIB01_RS15590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UIB01_RS15595	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
UIB01_RS15595	COG0506	proline dehydrogenase activity
UIB01_RS15595	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
UIB01_RS15605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UIB01_RS15620	COG2226	methyltransferase
UIB01_RS15625	COG0500	methyltransferase
UIB01_RS15635	COG0583	DNA-binding transcription factor activity
UIB01_RS15645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
UIB01_RS15650	COG1381	Involved in DNA repair and RecF pathway recombination
UIB01_RS15660	COG0571	ribonuclease III activity
UIB01_RS15675	COG0481	GTPase activity
UIB01_RS15680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UIB01_RS15730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UIB01_RS15740	COG1024	Enoyl-CoA hydratase
UIB01_RS15755	COG4657	Part of a membrane complex involved in electron transport
UIB01_RS15760	COG2878	Part of a membrane complex involved in electron transport
UIB01_RS15770	COG4658	electron transport chain
UIB01_RS15775	COG4659	FMN binding
UIB01_RS15785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UIB01_RS15795	COG0346	lactoylglutathione lyase activity
UIB01_RS15800	COG0137	argininosuccinate synthase activity
UIB01_RS15810	COG0418	dihydroorotase activity
UIB01_RS15815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UIB01_RS15830	COG3791	Glutathione-dependent formaldehyde-activating
UIB01_RS15845	COG0335	large ribosomal subunit rRNA binding
UIB01_RS15850	COG0336	Belongs to the RNA methyltransferase TrmD family
UIB01_RS15855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
UIB01_RS15860	COG0228	four-way junction DNA binding
UIB01_RS15865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UIB01_RS15870	COG4137	Cytochrome C assembly protein
UIB01_RS15875	COG4536	flavin adenine dinucleotide binding
UIB01_RS15880	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
UIB01_RS15905	COG3034	peptidoglycan biosynthetic process
UIB01_RS15915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UIB01_RS15915	COG0047	phosphoribosylformylglycinamidine synthase activity
UIB01_RS15920	COG1126	abc transporter atp-binding protein
UIB01_RS15925	COG0765	amino acid transport
UIB01_RS15930	COG4597	amino acid ABC transporter
UIB01_RS15935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UIB01_RS15940	COG0400	carboxylic ester hydrolase activity
UIB01_RS15955	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
UIB01_RS15960	COG0315	cyclic pyranopterin monophosphate synthase activity
UIB01_RS15965	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
UIB01_RS15970	COG1230	cation diffusion facilitator family transporter
UIB01_RS15975	COG3022	response to hydroperoxide
UIB01_RS15990	COG0433	COG0433 Predicted ATPase
UIB01_RS16000	COG0788	formyltetrahydrofolate deformylase activity
UIB01_RS16010	COG2925	Exonuclease
UIB01_RS16035	COG0714	Associated with various cellular activities
UIB01_RS16080	COG4628	conserved protein (DUF2132)
UIB01_RS16085	COG0693	protein deglycase activity
UIB01_RS16090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UIB01_RS16110	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
UIB01_RS16130	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS16135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
UIB01_RS16150	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
UIB01_RS16170	COG0559	Belongs to the binding-protein-dependent transport system permease family
UIB01_RS16200	COG0318	PFAM AMP-dependent synthetase and ligase
UIB01_RS16205	COG4294	response to UV
UIB01_RS16210	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS16215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UIB01_RS16220	COG1024	Enoyl-CoA hydratase
UIB01_RS16220	COG1250	3-hydroxyacyl-CoA dehydrogenase
UIB01_RS16250	COG0789	Transcriptional regulator
UIB01_RS16255	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UIB01_RS16265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UIB01_RS16280	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
UIB01_RS16305	COG0697	spore germination
UIB01_RS16310	COG0288	reversible hydration of carbon dioxide
UIB01_RS16320	COG1877	trehalose-phosphatase activity
UIB01_RS16330	COG0456	acetyltransferase
UIB01_RS16340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UIB01_RS16350	COG0019	diaminopimelate decarboxylase activity
UIB01_RS16370	COG3008	intermembrane lipid transfer
UIB01_RS16375	COG2995	paraquat-inducible protein a
UIB01_RS16380	COG2995	paraquat-inducible protein a
UIB01_RS16415	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
UIB01_RS16425	COG1183	phosphatidylcholine synthase activity
UIB01_RS16430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UIB01_RS16440	COG0028	Belongs to the TPP enzyme family
UIB01_RS16460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UIB01_RS16495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UIB01_RS16510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
UIB01_RS16525	COG2264	protein methyltransferase activity
UIB01_RS16545	COG0138	bifunctional purine biosynthesis protein purh
UIB01_RS16560	COG0784	Response regulator, receiver
UIB01_RS16560	COG2205	protein histidine kinase activity
UIB01_RS16560	COG5002	protein histidine kinase activity
UIB01_RS16565	COG2124	cytochrome p450
UIB01_RS16580	COG0679	Auxin Efflux Carrier
UIB01_RS16595	COG0436	Aminotransferase
UIB01_RS16600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UIB01_RS16605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UIB01_RS16615	COG4191	Histidine kinase
UIB01_RS16620	COG2204	response regulator
UIB01_RS16635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
UIB01_RS16640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
UIB01_RS16645	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
UIB01_RS16650	COG0166	Belongs to the GPI family
UIB01_RS16660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
UIB01_RS16685	COG1185	polyribonucleotide nucleotidyltransferase activity
UIB01_RS16690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
UIB01_RS16695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
UIB01_RS16700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
UIB01_RS16705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
UIB01_RS16710	COG0195	Participates in both transcription termination and antitermination
UIB01_RS16715	COG0779	Required for maturation of 30S ribosomal subunits
UIB01_RS16735	COG0149	triose-phosphate isomerase activity
UIB01_RS16740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UIB01_RS16745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UIB01_RS16750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UIB01_RS16775	COG0505	Belongs to the CarA family
UIB01_RS16780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
UIB01_RS16785	COG0484	heat shock protein binding
UIB01_RS16790	COG0443	Heat shock 70 kDa protein
UIB01_RS16795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UIB01_RS16800	COG0497	DNA recombination
UIB01_RS16815	COG2914	Belongs to the UPF0125 (RnfH) family
UIB01_RS16825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UIB01_RS16835	COG1620	l-lactate permease
UIB01_RS16840	COG0247	lactate metabolic process
UIB01_RS16845	COG1139	Iron-sulfur cluster binding protein
UIB01_RS16895	COG2135	peptidase activity
UIB01_RS16945	COG0789	Transcriptional regulator
UIB01_RS17010	COG3012	SEC-C Motif Domain Protein
UIB01_RS17015	COG4372	Transposase
UIB01_RS17020	COG3436	PFAM IS66 Orf2 family protein
UIB01_RS17035	COG2124	cytochrome p450
UIB01_RS17050	COG3039	Transposase
UIB01_RS17070	COG0815	Transfers the fatty acyl group on membrane lipoproteins
UIB01_RS17175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UIB01_RS17180	COG1074	ATP-dependent DNA helicase activity
UIB01_RS17185	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
UIB01_RS17280	COG1280	lysine exporter protein (LysE YggA)
UIB01_RS17290	COG0366	Alpha amylase catalytic
UIB01_RS17305	COG3833	ABC-type maltose transport systems, permease component
UIB01_RS17310	COG1175	transmembrane transport
UIB01_RS17320	COG0366	Alpha amylase catalytic
UIB01_RS17335	COG4580	involved in the transport of maltose and maltodextrins
UIB01_RS17350	COG4989	oxidoreductase activity
UIB01_RS17360	COG0800	Aldolase
UIB01_RS17375	COG1737	Transcriptional regulator
UIB01_RS17395	COG2814	Major facilitator Superfamily
UIB01_RS17430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UIB01_RS17430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UIB01_RS17500	COG0420	3'-5' exonuclease activity
UIB01_RS17525	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UIB01_RS17530	COG3577	Aspartyl protease
UIB01_RS17535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UIB01_RS17545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UIB01_RS17550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
UIB01_RS17565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UIB01_RS17565	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UIB01_RS17580	COG2264	protein methyltransferase activity
UIB01_RS17590	COG0425	Belongs to the sulfur carrier protein TusA family
UIB01_RS17595	COG2391	methyltransferase activity
UIB01_RS17600	COG3118	belongs to the thioredoxin family
UIB01_RS17615	COG1136	(ABC) transporter
UIB01_RS17640	COG0848	biopolymer transport protein
UIB01_RS17645	COG0811	peptide transport
UIB01_RS17650	COG0811	peptide transport
UIB01_RS17660	COG3047	cAMP biosynthetic process
UIB01_RS17665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UIB01_RS17680	COG2814	Major facilitator Superfamily
UIB01_RS17695	COG0753	catalase activity
UIB01_RS17700	COG0203	ribosomal protein L17
UIB01_RS17705	COG0202	RNA polymerase activity
UIB01_RS17710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UIB01_RS17715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UIB01_RS17720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UIB01_RS17725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UIB01_RS17735	COG0200	Binds to the 23S rRNA
UIB01_RS17740	COG1841	ribosomal large subunit assembly
UIB01_RS17745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UIB01_RS17755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UIB01_RS17760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UIB01_RS17765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UIB01_RS17770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
UIB01_RS17775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UIB01_RS17780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UIB01_RS17785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UIB01_RS17790	COG0255	Belongs to the universal ribosomal protein uL29 family
UIB01_RS17795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UIB01_RS17800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UIB01_RS17805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UIB01_RS17810	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UIB01_RS17815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UIB01_RS17820	COG0089	rRNA binding
UIB01_RS17825	COG0088	Forms part of the polypeptide exit tunnel
UIB01_RS17830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UIB01_RS17835	COG0051	transcription antitermination factor activity, RNA binding
UIB01_RS17840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UIB01_RS17845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UIB01_RS17850	COG0049	tRNA binding
UIB01_RS17855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UIB01_RS17860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UIB01_RS17865	COG0085	RNA polymerase activity
UIB01_RS17870	COG0222	ribosome binding
UIB01_RS17880	COG0081	regulation of translation
UIB01_RS17885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
UIB01_RS17905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UIB01_RS17935	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
UIB01_RS17935	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
UIB01_RS17970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
UIB01_RS17975	COG0739	heme binding
UIB01_RS17980	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
UIB01_RS17985	COG0316	Belongs to the HesB IscA family
UIB01_RS17990	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UIB01_RS17995	COG1981	membrane
UIB01_RS18005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UIB01_RS18010	COG0537	adenosine 5'-monophosphoramidase activity
UIB01_RS18015	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
UIB01_RS18020	COG1765	OsmC-like protein
UIB01_RS18030	COG0134	indole-3-glycerol-phosphate synthase activity
UIB01_RS18035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UIB01_RS18040	COG0512	Glutamine amidotransferase of anthranilate synthase
UIB01_RS18050	COG0546	phosphoglycolate phosphatase activity
UIB01_RS18055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UIB01_RS18060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
UIB01_RS18075	COG1176	ABC-type spermidine putrescine transport system, permease component I
UIB01_RS18085	COG3842	ATPase activity
UIB01_RS18090	COG2197	response regulator
UIB01_RS18105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
UIB01_RS18110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
UIB01_RS18120	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
UIB01_RS18125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UIB01_RS18130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
UIB01_RS18135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UIB01_RS18140	COG2967	ApaG domain
UIB01_RS18145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
UIB01_RS18150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UIB01_RS18155	COG2766	serine protein kinase
UIB01_RS18160	COG2718	Belongs to the UPF0229 family
UIB01_RS18165	COG2719	SpoVR family
UIB01_RS18185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
UIB01_RS18190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
UIB01_RS18195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
UIB01_RS18200	COG0358	DNA primase activity
UIB01_RS18205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UIB01_RS18220	COG0471	metal ion transport
UIB01_RS18220	COG3273	potassium ion transport
UIB01_RS18225	COG2873	o-acetylhomoserine
UIB01_RS18230	COG3118	belongs to the thioredoxin family
UIB01_RS18245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UIB01_RS18250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UIB01_RS18260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UIB01_RS18275	COG2986	histidine ammonia-lyase
UIB01_RS18315	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS18320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UIB01_RS18335	COG0583	DNA-binding transcription factor activity
UIB01_RS18340	COG2814	Major facilitator Superfamily
UIB01_RS18350	COG0493	'glutamate synthase
UIB01_RS18355	COG0069	glutamate synthase activity
UIB01_RS18355	COG0070	glutamate synthase
UIB01_RS18355	COG0067	glutamate synthase
UIB01_RS18365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UIB01_RS18370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UIB01_RS18405	COG0281	malic enzyme
UIB01_RS18415	COG0254	rRNA binding
UIB01_RS18420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UIB01_RS18425	COG0018	arginyl-trna synthetase
UIB01_RS18440	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
UIB01_RS18460	COG0248	Ppx GppA phosphatase
UIB01_RS18465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
UIB01_RS18475	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
UIB01_RS18485	COG1671	Belongs to the UPF0178 family
UIB01_RS18490	COG1280	lysine exporter protein (LysE YggA)
UIB01_RS18500	COG0488	(ABC) transporter
UIB01_RS18520	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
UIB01_RS18550	COG3275	phosphorelay sensor kinase activity
UIB01_RS18555	COG0165	Argininosuccinate lyase
UIB01_RS18610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UIB01_RS18615	COG1965	Belongs to the frataxin family
UIB01_RS18630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
UIB01_RS18640	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
UIB01_RS18655	COG0432	Pfam Uncharacterised protein family UPF0047
UIB01_RS18660	COG0004	ammonium transporteR
UIB01_RS18665	COG0004	ammonium transporteR
UIB01_RS18670	COG0347	Belongs to the P(II) protein family
UIB01_RS18680	COG0606	chelatase, subunit chli
UIB01_RS18685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
UIB01_RS18695	COG0210	DNA helicase
UIB01_RS18700	COG1272	protein, Hemolysin III
UIB01_RS18705	COG1414	Transcriptional regulator
UIB01_RS18715	COG1454	alcohol dehydrogenase
UIB01_RS18725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UIB01_RS18730	COG0366	Alpha amylase catalytic
UIB01_RS18745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UIB01_RS18770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UIB01_RS18780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UIB01_RS18785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UIB01_RS18805	COG1250	3-hydroxyacyl-CoA dehydrogenase
UIB01_RS18820	COG2003	Belongs to the UPF0758 family
UIB01_RS18825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UIB01_RS18830	COG0756	dUTP diphosphatase activity
UIB01_RS18840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UIB01_RS18855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UIB01_RS18870	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
UIB01_RS18875	COG1561	YicC-like family, N-terminal region
UIB01_RS18885	COG1758	RNA polymerase activity
UIB01_RS18890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UIB01_RS18915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UIB01_RS18935	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
UIB01_RS18940	COG1704	LemA family
UIB01_RS18945	COG0583	DNA-binding transcription factor activity
UIB01_RS18950	COG0604	alcohol dehydrogenase
UIB01_RS18960	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS18965	COG0583	DNA-binding transcription factor activity
UIB01_RS18995	COG1620	l-lactate permease
UIB01_RS19000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
UIB01_RS19005	COG3193	protein, possibly involved in utilization of glycolate and propanediol
UIB01_RS19010	COG0247	lactate metabolic process
UIB01_RS19015	COG0277	FAD linked oxidase domain protein
UIB01_RS19020	COG0277	FAD linked oxidase domain protein
UIB01_RS19025	COG2186	Transcriptional regulator
UIB01_RS19035	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
UIB01_RS19050	COG1253	flavin adenine dinucleotide binding
UIB01_RS19055	COG0739	heme binding
UIB01_RS19075	COG0411	ABC transporter
UIB01_RS19085	COG0559	Belongs to the binding-protein-dependent transport system permease family
UIB01_RS19095	COG1192	Involved in chromosome partitioning
UIB01_RS19100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
UIB01_RS19105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
UIB01_RS19110	COG0730	response to heat
UIB01_RS19125	COG0494	nUDIX hydrolase
UIB01_RS19140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UIB01_RS19145	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
UIB01_RS19155	COG3204	pilus organization
UIB01_RS19165	COG0179	Fumarylacetoacetate (FAA) hydrolase
UIB01_RS19170	COG0277	FAD linked oxidase domain protein
UIB01_RS19175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UIB01_RS19200	COG2197	response regulator
UIB01_RS19240	COG0651	ATP synthesis coupled electron transport
UIB01_RS19245	COG0651	ATP synthesis coupled electron transport
UIB01_RS19250	COG1007	ATP synthesis coupled electron transport
UIB01_RS19265	COG1320	monovalent cation:proton antiporter activity
UIB01_RS19280	COG1966	Carbon starvation protein
UIB01_RS19290	COG0003	Pfam Anion-transporting ATPase
UIB01_RS19310	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
UIB01_RS19315	COG5001	Diguanylate cyclase
UIB01_RS19335	COG3383	formate dehydrogenase (NAD+) activity
UIB01_RS19360	COG4807	Protein conserved in bacteria
UIB01_RS19365	COG2204	response regulator
UIB01_RS19400	COG2963	transposase activity
UIB01_RS19405	COG2801	Transposase and inactivated derivatives
UIB01_RS19415	COG2826	transposase and inactivated derivatives, IS30 family
UIB01_RS19435	COG4565	transcriptional regulatory protein
UIB01_RS19440	COG3290	protein histidine kinase activity
UIB01_RS19450	COG0840	transmembrane signaling receptor activity
UIB01_RS19455	COG1217	gtp-binding protein TYPA
UIB01_RS19460	COG0301	tRNA thio-modification
UIB01_RS19460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UIB01_RS19480	COG3852	Histidine kinase
UIB01_RS19500	COG0243	molybdopterin cofactor binding
UIB01_RS19510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
UIB01_RS19525	COG2226	methyltransferase
UIB01_RS19535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UIB01_RS19540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UIB01_RS19545	COG0140	phosphoribosyl-ATP diphosphatase activity
UIB01_RS19550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UIB01_RS19555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UIB01_RS19575	COG1490	D-aminoacyl-tRNA deacylase activity
UIB01_RS19605	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
UIB01_RS19610	COG0058	SHG alpha-glucan phosphorylase activity
UIB01_RS19625	COG1218	3'(2'),5'-bisphosphate nucleotidase
UIB01_RS19630	COG0494	nUDIX hydrolase
UIB01_RS19635	COG1011	Hydrolase
UIB01_RS19645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UIB01_RS19655	COG0824	Thioesterase
UIB01_RS19660	COG1454	alcohol dehydrogenase
UIB01_RS19670	COG1250	3-hydroxyacyl-CoA dehydrogenase
UIB01_RS19670	COG1024	Enoyl-CoA hydratase
UIB01_RS19680	COG1366	Belongs to the anti-sigma-factor antagonist family
UIB01_RS19685	COG1366	Belongs to the anti-sigma-factor antagonist family
UIB01_RS19690	COG2172	sigma factor antagonist activity
UIB01_RS19700	COG2205	protein histidine kinase activity
UIB01_RS19705	COG0784	Response regulator, receiver
UIB01_RS19705	COG4191	Histidine kinase
UIB01_RS19710	COG1278	Cold shock
UIB01_RS19740	COG0667	Aldo Keto reductase
UIB01_RS19765	COG0019	diaminopimelate decarboxylase activity
UIB01_RS19775	COG1073	alpha beta
UIB01_RS19785	COG0514	ATP-dependent DNA helicase (RecQ)
UIB01_RS19795	COG0778	Nitroreductase
UIB01_RS19805	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
UIB01_RS19850	COG0463	Glycosyl transferase, family 2
UIB01_RS19890	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
UIB01_RS19895	COG0189	ligase activity
UIB01_RS19895	COG4067	protein conserved in archaea
UIB01_RS19900	COG0189	ligase activity
UIB01_RS19915	COG2183	response to ionizing radiation
UIB01_RS19925	COG2918	glutathione biosynthetic process
UIB01_RS19945	COG0306	phosphate transporter
UIB01_RS19950	COG1392	Phosphate transport regulator
UIB01_RS19960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UIB01_RS19970	COG2989	Protein conserved in bacteria
UIB01_RS19985	COG1764	response to oxidative stress
UIB01_RS19990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UIB01_RS20000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UIB01_RS20080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UIB01_RS20085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
UIB01_RS20090	COG0786	glutamate:sodium symporter activity
UIB01_RS20105	COG1028	Short-chain dehydrogenase reductase Sdr
UIB01_RS20115	COG3243	poly(R)-hydroxyalkanoic acid synthase
UIB01_RS20120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UIB01_RS20125	COG0842	Transport permease protein
UIB01_RS20125	COG1129	ABC transporter
UIB01_RS20130	COG0842	Transport permease protein
UIB01_RS20135	COG1538	Outer membrane efflux protein
UIB01_RS20150	COG2235	arginine
UIB01_RS20215	COG0515	serine threonine protein kinase
UIB01_RS20250	COG0732	type I restriction modification DNA specificity domain
UIB01_RS20255	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
UIB01_RS20260	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
UIB01_RS20265	COG2204	response regulator
UIB01_RS20270	COG0582	viral genome integration into host DNA
UIB01_RS20275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UIB01_RS20315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UIB01_RS20345	COG2205	protein histidine kinase activity
UIB01_RS20350	COG3185	4-Hydroxyphenylpyruvate dioxygenase
UIB01_RS20350	COG1082	Xylose isomerase domain protein TIM barrel
UIB01_RS20355	COG0318	PFAM AMP-dependent synthetase and ligase
UIB01_RS20360	COG0583	DNA-binding transcription factor activity
UIB01_RS20370	COG1301	dicarboxylic acid transport
UIB01_RS20380	COG1115	amino acid carrier protein
UIB01_RS20385	COG0252	asparaginase activity
UIB01_RS20400	COG2066	Belongs to the glutaminase family
UIB01_RS20415	COG0511	ligase activity, forming carbon-carbon bonds
UIB01_RS20415	COG5016	pyruvate
UIB01_RS20420	COG0439	Biotin carboxylase
UIB01_RS20425	COG0583	DNA-binding transcription factor activity
UIB01_RS20435	COG0837	glucose binding
UIB01_RS20435	COG1737	Transcriptional regulator
UIB01_RS20440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
UIB01_RS20445	COG0456	acetyltransferase
UIB01_RS20450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
UIB01_RS20455	COG1917	Cupin 2, conserved barrel domain protein
UIB01_RS20460	COG5285	phytanoyl-CoA dioxygenase
UIB01_RS20465	COG0527	aspartate kinase activity
UIB01_RS20470	COG2841	Protein conserved in bacteria
UIB01_RS20475	COG0826	peptidase U32
UIB01_RS20485	COG0210	DNA helicase
UIB01_RS20490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
UIB01_RS20505	COG1764	response to oxidative stress
UIB01_RS20525	COG0437	4 iron, 4 sulfur cluster binding
UIB01_RS20530	COG2864	formate dehydrogenase
UIB01_RS20535	COG3058	Necessary for formate dehydrogenase activity
UIB01_RS20540	COG1921	L-seryl-tRNASec selenium transferase activity
UIB01_RS20545	COG3276	selenocysteine insertion sequence binding
UIB01_RS20560	COG0509	glycine decarboxylation via glycine cleavage system
UIB01_RS20570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
UIB01_RS20575	COG0589	response to stress
UIB01_RS20580	COG0659	secondary active sulfate transmembrane transporter activity
UIB01_RS20595	COG2204	response regulator
UIB01_RS20605	COG3795	YCII-related domain
UIB01_RS20630	COG0784	Response regulator, receiver
UIB01_RS20630	COG4191	Histidine kinase
UIB01_RS20635	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS20655	COG4786	Flagellar basal body rod
UIB01_RS20655	COG1256	bacterial-type flagellum assembly
UIB01_RS20660	COG0741	lytic transglycosylase activity
UIB01_RS20665	COG1706	bacterial-type flagellum-dependent cell motility
UIB01_RS20675	COG4786	Flagellar basal body rod
UIB01_RS20680	COG4787	bacterial-type flagellum-dependent cell motility
UIB01_RS20690	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
UIB01_RS20695	COG1558	bacterial-type flagellum-dependent cell motility
UIB01_RS20710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UIB01_RS20730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
UIB01_RS20735	COG1191	sigma factor activity
UIB01_RS20760	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
UIB01_RS20790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UIB01_RS20860	COG2890	protein-(glutamine-N5) methyltransferase activity
UIB01_RS20885	COG0583	DNA-binding transcription factor activity
UIB01_RS20890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UIB01_RS20960	COG2249	NAD(P)H dehydrogenase (quinone) activity
UIB01_RS20970	COG2207	Transcriptional regulator
UIB01_RS21040	COG1611	Belongs to the LOG family
UIB01_RS21055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UIB01_RS21060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UIB01_RS21065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UIB01_RS21070	COG0318	PFAM AMP-dependent synthetase and ligase
UIB01_RS21090	COG2814	Major facilitator Superfamily
UIB01_RS21115	COG1960	acyl-CoA dehydrogenase activity
UIB01_RS21120	COG1024	Enoyl-CoA hydratase
UIB01_RS21120	COG1250	3-hydroxyacyl-CoA dehydrogenase
UIB01_RS21135	COG3909	cytochrome
UIB01_RS21140	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
UIB01_RS21210	COG2826	transposase and inactivated derivatives, IS30 family
UIB01_RS21220	COG0753	catalase activity
UIB01_RS21225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
UIB01_RS21230	COG1127	ABC transporter
UIB01_RS21245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UIB01_RS21250	COG1129	ABC transporter
UIB01_RS21250	COG0842	Transport permease protein
UIB01_RS21255	COG0842	Transport permease protein
UIB01_RS21260	COG3706	GGDEF domain
UIB01_RS21320	COG0596	Alpha beta hydrolase
UIB01_RS21330	COG1177	transmembrane transport
UIB01_RS21335	COG1176	ABC-type spermidine putrescine transport system, permease component I
UIB01_RS21340	COG3842	ATPase activity
UIB01_RS21360	COG0174	glutamine synthetase
UIB01_RS21365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
UIB01_RS21370	COG0174	glutamine synthetase
UIB01_RS21385	COG2957	Belongs to the agmatine deiminase family
UIB01_RS21395	COG3706	GGDEF domain
UIB01_RS21405	COG4191	Histidine kinase
UIB01_RS21410	COG0745	RESPONSE REGULATOR receiver
UIB01_RS21415	COG5002	protein histidine kinase activity
UIB01_RS21420	COG0745	RESPONSE REGULATOR receiver
UIB01_RS21430	COG1012	belongs to the aldehyde dehydrogenase family
UIB01_RS21435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UIB01_RS21445	COG0735	belongs to the Fur family
UIB01_RS21450	COG1121	(ABC) transporter
UIB01_RS21455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UIB01_RS21460	COG1451	nucleotide metabolic process
UIB01_RS21475	COG2011	ABC-type metal ion transport system permease component
UIB01_RS21495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
UIB01_RS21530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
UIB01_RS21535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
UIB01_RS21540	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
UIB01_RS21570	COG0109	protoheme IX farnesyltransferase activity
UIB01_RS21595	COG1595	DNA-templated transcription, initiation
UIB01_RS21610	COG0523	cobalamin synthesis protein
UIB01_RS21625	COG4251	negative regulation of phosphorylation
UIB01_RS21630	COG0784	Response regulator, receiver
UIB01_RS21635	COG0784	Response regulator, receiver
UIB01_RS21635	COG4191	Histidine kinase
UIB01_RS21645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UIB01_RS21650	COG1349	DNA-binding transcription factor activity
UIB01_RS21660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
UIB01_RS21665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
UIB01_RS21670	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UIB01_RS21675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UIB01_RS21680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
UIB01_RS21685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UIB01_RS21690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
UIB01_RS21700	COG0356	it plays a direct role in the translocation of protons across the membrane
UIB01_RS21710	COG1475	DNA binding
UIB01_RS21715	COG1192	Involved in chromosome partitioning
UIB01_RS21720	COG0357	Ribosomal RNA small subunit methyltransferase G
UIB01_RS21725	COG0445	tRNA wobble uridine modification
UIB01_RS21730	COG1320	monovalent cation:proton antiporter activity
UIB01_RS21740	COG1863	multisubunit Na H antiporter MnhE subunit
UIB01_RS21745	COG0651	ATP synthesis coupled electron transport
UIB01_RS21750	COG1006	Multisubunit Na H antiporter MnhC subunit
UIB01_RS21755	COG2111	Na H antiporter
UIB01_RS21760	COG2111	Na H antiporter
UIB01_RS21760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UIB01_RS21765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
UIB01_RS21770	COG0706	membrane insertase activity
UIB01_RS21775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
UIB01_RS21780	COG0594	ribonuclease P activity
UIB01_RS21785	COG0230	Belongs to the bacterial ribosomal protein bL34 family
UIB01_RS21810	COG0675	Transposase, IS605 OrfB family
UIB01_RS21830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UIB01_RS21840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UIB01_RS21865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UIB01_RS21890	COG1538	Outer membrane efflux protein
UIB01_RS21895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UIB01_RS22200	COG3436	PFAM IS66 Orf2 family protein
UIB01_RS22220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UIB01_RS22225	COG3039	Transposase
UIB01_RS22300	COG0277	FAD linked oxidase domain protein
UIB01_RS22325	COG1074	ATP-dependent DNA helicase activity
UIB01_RS22345	COG2337	Toxic component of a toxin-antitoxin (TA) module
UIB01_RS22350	COG2336	PFAM SpoVT AbrB
UIB01_RS22355	COG4974	Belongs to the 'phage' integrase family
UIB01_RS22380	COG1192	Involved in chromosome partitioning
UIB01_RS22395	COG3436	PFAM IS66 Orf2 family protein
UIB01_RS22400	COG4372	Transposase
UIB01_RS22465	COG3436	PFAM IS66 Orf2 family protein
UIB01_RS22505	COG2197	response regulator
UIB01_RS22520	COG2205	protein histidine kinase activity
UIB01_RS22520	COG3437	response regulator, receiver
UIB01_RS22520	COG3850	Histidine kinase
UIB01_RS22520	COG4999	Histidine kinase
UIB01_RS22535	COG3941	tape measure
UIB01_RS22540	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UIB01_RS22690	COG3130	regulation of translation
UIB01_RS22760	COG0720	synthase
UIB01_RS22810	COG0653	protein targeting
UIB01_RS22820	COG3755	Protein conserved in bacteria
UIB01_RS22835	COG4890	Cyd operon protein YbgT
UIB01_RS22905	COG0789	Transcriptional regulator
UIB01_RS23035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
UIB01_RS23140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
UIB01_RS23370	COG0789	Transcriptional regulator
UIB01_RS23375	COG0789	Transcriptional regulator
UIB01_RS23430	COG0640	Transcriptional regulator
UIB01_RS23435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UIB01_RS23460	COG0840	transmembrane signaling receptor activity
UIB01_RS23520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein