locus-tag	class	description
A458_RS21810	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A458_RS21815	COG0592	DNA-directed DNA polymerase activity
A458_RS21820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A458_RS21865	COG3077	Addiction module antitoxin, RelB DinJ family
A458_RS21870	COG2026	Addiction module toxin, RelE StbE family
A458_RS21885	COG3706	GGDEF domain
A458_RS21900	COG0751	glycine-tRNA ligase activity
A458_RS21905	COG0752	glycyl-tRNA synthetase alpha subunit
A458_RS21910	COG2818	Glycosylase
A458_RS21930	COG1126	abc transporter atp-binding protein
A458_RS21935	COG0765	amino acid transport
A458_RS21940	COG0765	amino acid transport
A458_RS21945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A458_RS21950	COG0569	domain protein
A458_RS21955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A458_RS21960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A458_RS21965	COG0242	peptide deformylase activity
A458_RS21970	COG1652	LysM domain
A458_RS21975	COG0758	DNA mediated transformation
A458_RS21980	COG0009	L-threonylcarbamoyladenylate synthase
A458_RS21990	COG0408	coproporphyrinogen oxidase activity
A458_RS21995	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A458_RS22010	COG1686	Belongs to the peptidase S11 family
A458_RS22065	COG0583	DNA-binding transcription factor activity
A458_RS22070	COG2323	membrane
A458_RS22085	COG1132	(ABC) transporter
A458_RS22090	COG3340	Belongs to the peptidase S51 family
A458_RS22120	COG0625	glutathione transferase activity
A458_RS22125	COG1396	sequence-specific DNA binding
A458_RS22130	COG3550	peptidyl-serine autophosphorylation
A458_RS22150	COG0159	tryptophan synthase activity
A458_RS22155	COG0133	tryptophan synthase activity
A458_RS22170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A458_RS22190	COG1132	(ABC) transporter
A458_RS22195	COG4249	Peptidase C14 caspase catalytic subunit p20
A458_RS22200	COG3360	Dodecin
A458_RS22210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A458_RS22250	COG2358	TRAP transporter, solute receptor (TAXI family
A458_RS22265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A458_RS22275	COG3454	Phosphonate metabolism
A458_RS22280	COG4778	phosphonate C-P lyase system protein PhnL
A458_RS22285	COG4107	phosphonate C-P lyase system protein PhnK
A458_RS22290	COG3627	carbon phosphorus lyase activity
A458_RS22295	COG3626	phosphonate metabolism
A458_RS22305	COG3624	Phosphonate C-P lyase system protein PhnG
A458_RS22310	COG2188	Transcriptional regulator
A458_RS22315	COG3639	organic phosphonate transmembrane transporter activity
A458_RS22320	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A458_RS22330	COG4221	oxidoreductase activity
A458_RS22340	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A458_RS22345	COG3052	prosthetic group binding
A458_RS22365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A458_RS22390	COG4944	Protein of unknown function (DUF1109)
A458_RS22395	COG1595	DNA-templated transcription, initiation
A458_RS22405	COG3220	belongs to the UPF0276 family
A458_RS22425	COG3675	Pfam Lipase (class 3)
A458_RS22445	COG2204	response regulator
A458_RS22500	COG0676	glucose-6-phosphate 1-epimerase activity
A458_RS22515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A458_RS22525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A458_RS22560	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A458_RS22570	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A458_RS22575	COG1194	a g-specific adenine glycosylase
A458_RS22590	COG1116	anion transmembrane transporter activity
A458_RS22600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A458_RS22605	COG3707	response regulator
A458_RS22610	COG0131	Imidazoleglycerol-phosphate dehydratase
A458_RS22625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A458_RS22630	COG0107	imidazoleglycerol-phosphate synthase activity
A458_RS22650	COG0793	Belongs to the peptidase S41A family
A458_RS22655	COG4942	peptidase
A458_RS22660	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A458_RS22665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A458_RS22675	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A458_RS22695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A458_RS22710	COG3079	Belongs to the UPF0149 family
A458_RS22715	COG0006	proline dipeptidase activity
A458_RS22720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A458_RS22730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A458_RS22740	COG1178	ABC-type Fe3 transport system permease component
A458_RS22755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A458_RS22755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A458_RS22760	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A458_RS22785	COG3023	N-Acetylmuramoyl-L-alanine amidase
A458_RS22795	COG5002	protein histidine kinase activity
A458_RS22800	COG2204	response regulator
A458_RS22820	COG0700	Nucleoside recognition
A458_RS22830	COG2358	TRAP transporter, solute receptor (TAXI family
A458_RS22835	COG0840	transmembrane signaling receptor activity
A458_RS22845	COG5001	Diguanylate cyclase
A458_RS22845	COG4251	negative regulation of phosphorylation
A458_RS22845	COG3706	GGDEF domain
A458_RS22845	COG2203	Gaf domain
A458_RS22880	COG3180	Ammonia monooxygenase
A458_RS22885	COG1283	sodium-dependent phosphate transmembrane transporter activity
A458_RS22895	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A458_RS22900	COG1074	ATP-dependent DNA helicase activity
A458_RS22905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A458_RS22920	COG5002	protein histidine kinase activity
A458_RS22920	COG3447	MASE1 domain protein
A458_RS22920	COG5001	Diguanylate cyclase
A458_RS22925	COG1607	acyl-coa hydrolase
A458_RS22940	COG0573	inorganic phosphate transmembrane transporter activity
A458_RS22945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A458_RS22950	COG0704	Plays a role in the regulation of phosphate uptake
A458_RS22965	COG1160	GTP binding
A458_RS22995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A458_RS23005	COG0129	dihydroxy-acid dehydratase activity
A458_RS23015	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A458_RS23020	COG0693	protein deglycase activity
A458_RS23030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A458_RS23050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A458_RS23060	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A458_RS23095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A458_RS23110	COG0742	ribosomal rna small subunit methyltransferase
A458_RS23115	COG0612	Peptidase, M16
A458_RS23120	COG0612	Peptidase, M16
A458_RS23125	COG0552	protein localization to endoplasmic reticulum
A458_RS23130	COG2884	Cell division ATP-binding protein ftsE
A458_RS23135	COG2177	Part of the ABC transporter FtsEX involved in
A458_RS23155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A458_RS23160	COG2363	Small membrane protein
A458_RS23170	COG2022	thiamine diphosphate biosynthetic process
A458_RS23175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A458_RS23195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A458_RS23200	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A458_RS23210	COG2813	Specifically methylates the guanine in position
A458_RS23210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A458_RS23215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A458_RS23220	COG1160	GTP binding
A458_RS23265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A458_RS23270	COG0540	Belongs to the ATCase OTCase family
A458_RS23280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A458_RS23285	COG1678	Uncharacterized ACR, COG1678
A458_RS23325	COG2198	Histidine kinase
A458_RS23325	COG0784	Response regulator, receiver
A458_RS23325	COG0643	Histidine kinase
A458_RS23330	COG2201	protein-glutamate methylesterase activity
A458_RS23340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A458_RS23350	COG3038	cytochrome b561
A458_RS23355	COG2353	YceI-like domain
A458_RS23360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A458_RS23375	COG0513	Belongs to the DEAD box helicase family
A458_RS23380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A458_RS23385	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A458_RS23405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A458_RS23410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A458_RS23415	COG1131	(ABC) transporter
A458_RS23420	COG0842	Transport permease protein
A458_RS23430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A458_RS23435	COG2226	methyltransferase
A458_RS23445	COG2175	clavaminate synthase activity
A458_RS23450	COG0583	DNA-binding transcription factor activity
A458_RS23455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A458_RS23460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A458_RS23465	COG0126	phosphoglycerate kinase activity
A458_RS23475	COG0191	fructose-bisphosphate aldolase activity
A458_RS23515	COG2081	HI0933 family
A458_RS23525	COG1289	transmembrane transporter activity
A458_RS23530	COG0513	Belongs to the DEAD box helicase family
A458_RS23540	COG3039	Transposase
A458_RS23550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A458_RS23640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A458_RS23670	COG0583	DNA-binding transcription factor activity
A458_RS23695	COG4948	Mandelate Racemase Muconate Lactonizing
A458_RS23700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A458_RS23705	COG1012	belongs to the aldehyde dehydrogenase family
A458_RS23715	COG2721	sulfolactate sulfo-lyase activity
A458_RS23720	COG4774	siderophore transport
A458_RS23740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A458_RS23760	COG0330	HflC and HflK could
A458_RS23790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A458_RS23805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A458_RS23810	COG1196	nuclear chromosome segregation
A458_RS23810	COG3264	Mechanosensitive ion channel
A458_RS23815	COG3263	regulation of cellular component size
A458_RS23820	COG1960	acyl-CoA dehydrogenase activity
A458_RS23830	COG1304	FMN binding
A458_RS23865	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A458_RS23870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A458_RS23875	COG1040	competence protein
A458_RS23880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A458_RS23885	COG0156	8-amino-7-oxononanoate synthase activity
A458_RS23890	COG1073	alpha beta
A458_RS23890	COG2226	methyltransferase
A458_RS23910	COG1960	acyl-CoA dehydrogenase activity
A458_RS23920	COG1960	acyl-CoA dehydrogenase activity
A458_RS23925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A458_RS23950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A458_RS23960	COG0859	PFAM glycosyl transferase family 9
A458_RS23965	COG0859	PFAM glycosyl transferase family 9
A458_RS23970	COG0438	transferase activity, transferring glycosyl groups
A458_RS23995	COG2192	nodulation
A458_RS24000	COG1215	transferase activity, transferring glycosyl groups
A458_RS24010	COG3562	capsule polysaccharide
A458_RS24030	COG1132	(ABC) transporter
A458_RS24045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A458_RS24045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A458_RS24055	COG0667	Aldo Keto reductase
A458_RS24070	COG1519	Transferase
A458_RS24075	COG1538	Outer membrane efflux protein
A458_RS24080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A458_RS24090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A458_RS24105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A458_RS24125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A458_RS24130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A458_RS24130	COG2755	lipolytic protein G-D-S-L family
A458_RS24150	COG0438	transferase activity, transferring glycosyl groups
A458_RS24155	COG0662	Cupin 2, conserved barrel domain protein
A458_RS24155	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A458_RS24165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A458_RS24180	COG0494	nUDIX hydrolase
A458_RS24190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A458_RS24195	COG3150	esterase
A458_RS24235	COG0560	Phosphoserine phosphatase
A458_RS24235	COG3830	Belongs to the UPF0237 family
A458_RS24240	COG1063	alcohol dehydrogenase
A458_RS24245	COG2200	EAL domain
A458_RS24255	COG0688	phosphatidylethanolamine metabolic process
A458_RS24270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A458_RS24275	COG1360	Flagellar Motor Protein
A458_RS24280	COG1162	GTPase activity
A458_RS24290	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A458_RS24295	COG0702	epimerase
A458_RS24315	COG1346	cytolysis
A458_RS24325	COG2267	carboxylic ester hydrolase activity
A458_RS24330	COG0586	Pfam SNARE associated Golgi protein
A458_RS24335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A458_RS24340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A458_RS24350	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A458_RS24355	COG0768	penicillin binding
A458_RS24360	COG0772	Belongs to the SEDS family
A458_RS24365	COG2951	lytic endotransglycosylase activity
A458_RS24375	COG1686	Belongs to the peptidase S11 family
A458_RS24380	COG2921	Belongs to the UPF0250 family
A458_RS24385	COG0321	lipoyl(octanoyl) transferase activity
A458_RS24390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A458_RS24400	COG2951	lytic endotransglycosylase activity
A458_RS24420	COG0495	leucyl-tRNA aminoacylation
A458_RS24435	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A458_RS24440	COG4535	Mg2 and Co2 transporter CorC
A458_RS24445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A458_RS24450	COG1702	phosphate starvation-inducible protein PhoH
A458_RS24455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A458_RS24470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A458_RS24475	COG0352	thiamine-phosphate diphosphorylase activity
A458_RS24480	COG0351	phosphomethylpyrimidine kinase
A458_RS24480	COG0352	thiamine-phosphate diphosphorylase activity
A458_RS24490	COG1960	acyl-CoA dehydrogenase activity
A458_RS24500	COG0427	acetyl-CoA hydrolase
A458_RS24505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A458_RS24520	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A458_RS24525	COG0830	nickel cation binding
A458_RS24530	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A458_RS24545	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A458_RS24555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A458_RS24565	COG1953	Uracil, thiamine, allantoin
A458_RS24575	COG0804	urea catabolic process
A458_RS24580	COG0832	Belongs to the urease beta subunit family
A458_RS24590	COG0831	urea catabolic process
A458_RS24595	COG0829	nickel cation binding
A458_RS24640	COG1522	sequence-specific DNA binding
A458_RS24660	COG1643	Atp-dependent helicase
A458_RS24670	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS24690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A458_RS24695	COG0142	geranyltranstransferase activity
A458_RS24700	COG1722	exodeoxyribonuclease VII activity
A458_RS24730	COG0076	glutamate decarboxylase activity
A458_RS24740	COG5001	Diguanylate cyclase
A458_RS24750	COG3039	Transposase
A458_RS24765	COG3228	Belongs to the MtfA family
A458_RS24780	COG4303	Ethanolamine ammonia lyase large subunit
A458_RS24785	COG0531	amino acid
A458_RS24795	COG1454	alcohol dehydrogenase
A458_RS24800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A458_RS24825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A458_RS24825	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A458_RS24830	COG0802	atpase or kinase
A458_RS24835	COG0860	N-Acetylmuramoyl-L-alanine amidase
A458_RS24840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A458_RS24845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A458_RS24850	COG1923	regulation of RNA biosynthetic process
A458_RS24855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A458_RS24860	COG0330	HflC and HflK could
A458_RS24865	COG0330	HflC and HflK could
A458_RS24870	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A458_RS24875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A458_RS24890	COG0557	exoribonuclease II activity
A458_RS24895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A458_RS24905	COG0360	Binds together with S18 to 16S ribosomal RNA
A458_RS24910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A458_RS24920	COG0359	binds to the 23S rRNA
A458_RS24925	COG0305	Participates in initiation and elongation during chromosome replication
A458_RS24930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A458_RS25010	COG1252	NADH dehydrogenase
A458_RS25035	COG2945	thiolester hydrolase activity
A458_RS25045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A458_RS25055	COG1515	deoxyribonuclease V activity
A458_RS25060	COG3023	N-Acetylmuramoyl-L-alanine amidase
A458_RS25075	COG0084	hydrolase, TatD family'
A458_RS25085	COG2169	Transcriptional regulator
A458_RS25085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A458_RS25095	COG1538	Outer membrane efflux protein
A458_RS25100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A458_RS25115	COG0840	transmembrane signaling receptor activity
A458_RS25125	COG2217	Heavy metal translocating P-type atpase
A458_RS25140	COG2814	Major facilitator Superfamily
A458_RS25145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A458_RS25175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A458_RS25180	COG0778	Nitroreductase
A458_RS25185	COG0596	Alpha beta hydrolase
A458_RS25190	COG0251	oxidation-reduction process
A458_RS25195	COG1335	isochorismatase
A458_RS25200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A458_RS25205	COG1309	transcriptional regulator
A458_RS25235	COG1309	transcriptional regulator
A458_RS25240	COG1902	pentaerythritol trinitrate reductase activity
A458_RS25245	COG0640	Transcriptional regulator
A458_RS25255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A458_RS25265	COG1253	flavin adenine dinucleotide binding
A458_RS25275	COG0346	lactoylglutathione lyase activity
A458_RS25310	COG3845	ABC transporter
A458_RS25320	COG1079	Belongs to the binding-protein-dependent transport system permease family
A458_RS25340	COG1278	Cold shock
A458_RS25345	COG2824	Alkylphosphonate utilization operon protein PhnA
A458_RS25350	COG1607	acyl-coa hydrolase
A458_RS25360	COG0402	S-adenosylhomocysteine deaminase activity
A458_RS25365	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A458_RS25370	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A458_RS25385	COG2154	pterin-4-alpha-carbinolamine dehydratase
A458_RS25405	COG1760	l-serine dehydratase
A458_RS25410	COG0492	ferredoxin-NADP+ reductase activity
A458_RS25440	COG1960	acyl-CoA dehydrogenase activity
A458_RS25445	COG0348	domain, Protein
A458_RS25445	COG3901	Regulator of nitric oxide reductase transcription
A458_RS25450	COG4263	nitrous-oxide reductase activity
A458_RS25465	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A458_RS25485	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS25495	COG3278	Belongs to the heme-copper respiratory oxidase family
A458_RS25515	COG1648	precorrin-2 dehydrogenase activity
A458_RS25515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A458_RS25520	COG0535	radical SAM domain protein
A458_RS25530	COG1845	cytochrome c oxidase, subunit III
A458_RS25535	COG0714	Associated with various cellular activities
A458_RS25550	COG2010	Cytochrome c
A458_RS25555	COG3391	amine dehydrogenase activity
A458_RS25580	COG2010	Cytochrome c
A458_RS25585	COG3256	nitric oxide reductase
A458_RS25605	COG4580	involved in the transport of maltose and maltodextrins
A458_RS25625	COG0366	Alpha amylase catalytic
A458_RS25635	COG1175	transmembrane transport
A458_RS25640	COG3833	ABC-type maltose transport systems, permease component
A458_RS25660	COG0366	Alpha amylase catalytic
A458_RS25670	COG1280	lysine exporter protein (LysE YggA)
A458_RS25685	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A458_RS25690	COG0732	type I restriction modification DNA specificity domain
A458_RS25710	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A458_RS25730	COG0582	viral genome integration into host DNA
A458_RS25750	COG1139	Iron-sulfur cluster binding protein
A458_RS25755	COG0247	lactate metabolic process
A458_RS25760	COG1620	l-lactate permease
A458_RS25770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A458_RS25780	COG2914	Belongs to the UPF0125 (RnfH) family
A458_RS25795	COG0497	DNA recombination
A458_RS25800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A458_RS25805	COG0443	Heat shock 70 kDa protein
A458_RS25810	COG0484	heat shock protein binding
A458_RS25815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A458_RS25820	COG0505	Belongs to the CarA family
A458_RS25850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A458_RS25855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A458_RS25860	COG0149	triose-phosphate isomerase activity
A458_RS25865	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A458_RS25880	COG0779	Required for maturation of 30S ribosomal subunits
A458_RS25885	COG0195	Participates in both transcription termination and antitermination
A458_RS25885	COG2251	uridine kinase activity
A458_RS25890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A458_RS25895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A458_RS25900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A458_RS25905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A458_RS25910	COG1185	polyribonucleotide nucleotidyltransferase activity
A458_RS25935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A458_RS25945	COG0166	Belongs to the GPI family
A458_RS25950	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A458_RS25955	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A458_RS25960	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A458_RS25980	COG4191	Histidine kinase
A458_RS25990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A458_RS25995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A458_RS26000	COG0436	Aminotransferase
A458_RS26015	COG0679	Auxin Efflux Carrier
A458_RS26030	COG0784	Response regulator, receiver
A458_RS26030	COG2205	protein histidine kinase activity
A458_RS26030	COG5002	protein histidine kinase activity
A458_RS26040	COG0138	bifunctional purine biosynthesis protein purh
A458_RS26060	COG2264	protein methyltransferase activity
A458_RS26075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A458_RS26090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A458_RS26125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A458_RS26145	COG0028	Belongs to the TPP enzyme family
A458_RS26155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A458_RS26160	COG1183	phosphatidylcholine synthase activity
A458_RS26170	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A458_RS26205	COG2995	paraquat-inducible protein a
A458_RS26210	COG2995	paraquat-inducible protein a
A458_RS26215	COG3008	intermembrane lipid transfer
A458_RS26235	COG0019	diaminopimelate decarboxylase activity
A458_RS26245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A458_RS26255	COG0456	acetyltransferase
A458_RS26265	COG1877	trehalose-phosphatase activity
A458_RS26270	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A458_RS26275	COG0288	reversible hydration of carbon dioxide
A458_RS26280	COG0697	spore germination
A458_RS26290	COG1120	ATPase activity
A458_RS26305	COG0840	transmembrane signaling receptor activity
A458_RS26310	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A458_RS26325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A458_RS26340	COG0789	Transcriptional regulator
A458_RS26370	COG1024	Enoyl-CoA hydratase
A458_RS26375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A458_RS26380	COG1960	acyl-CoA dehydrogenase activity
A458_RS26385	COG4294	response to UV
A458_RS26390	COG0318	PFAM AMP-dependent synthetase and ligase
A458_RS26420	COG0559	Belongs to the binding-protein-dependent transport system permease family
A458_RS26470	COG0582	viral genome integration into host DNA
A458_RS26485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A458_RS26505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A458_RS26510	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A458_RS26520	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A458_RS26525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A458_RS26535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A458_RS26540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A458_RS26560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A458_RS26565	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A458_RS26605	COG0653	protein targeting
A458_RS26610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A458_RS26620	COG0494	nUDIX hydrolase
A458_RS26650	COG2096	Adenosyltransferase
A458_RS26655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A458_RS26655	COG4191	Histidine kinase
A458_RS26665	COG0745	RESPONSE REGULATOR receiver
A458_RS26670	COG1666	GTP binding
A458_RS26675	COG0668	transmembrane transport
A458_RS26685	COG3695	enzyme binding
A458_RS26695	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS26705	COG3030	protein affecting phage T7 exclusion by the F plasmid
A458_RS26710	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A458_RS26715	COG0459	protein refolding
A458_RS26725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A458_RS26760	COG1704	LemA family
A458_RS26785	COG1279	arginine transmembrane transporter activity
A458_RS26790	COG0583	DNA-binding transcription factor activity
A458_RS26810	COG3706	GGDEF domain
A458_RS26815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A458_RS26830	COG1017	nitric oxide dioxygenase activity
A458_RS26830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A458_RS26840	COG0469	pyruvate kinase activity
A458_RS26850	COG2084	Dehydrogenase
A458_RS26855	COG3622	Belongs to the hyi family
A458_RS26860	COG3960	tartronate-semialdehyde synthase activity
A458_RS26865	COG0583	DNA-binding transcription factor activity
A458_RS26870	COG2351	hydroxyisourate hydrolase activity
A458_RS26895	COG3300	MHYT domain
A458_RS26895	COG5001	Diguanylate cyclase
A458_RS26915	COG2233	PERMEase
A458_RS26920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A458_RS26920	COG4651	solute:proton antiporter activity
A458_RS26930	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A458_RS26935	COG4266	Belongs to the allantoicase family
A458_RS26960	COG2252	PERMEase
A458_RS26965	COG1802	Transcriptional regulator
A458_RS26985	COG0402	S-adenosylhomocysteine deaminase activity
A458_RS27025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A458_RS27030	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A458_RS27050	COG2326	polyphosphate kinase activity
A458_RS27055	COG3081	Nucleoid-associated protein
A458_RS27075	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A458_RS27080	COG0477	Major facilitator Superfamily
A458_RS27085	COG0490	domain, Protein
A458_RS27085	COG0471	metal ion transport
A458_RS27115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A458_RS27120	COG0795	lipopolysaccharide-transporting ATPase activity
A458_RS27125	COG0795	lipopolysaccharide-transporting ATPase activity
A458_RS27135	COG1278	Cold shock
A458_RS27145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A458_RS27155	COG1862	Preprotein translocase
A458_RS27170	COG3134	Outer membrane lipoprotein
A458_RS27195	COG1104	cysteine desulfurase activity
A458_RS27205	COG0316	Belongs to the HesB IscA family
A458_RS27210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A458_RS27215	COG0443	Heat shock 70 kDa protein
A458_RS27230	COG0105	UTP biosynthetic process
A458_RS27235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A458_RS27250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A458_RS27255	COG0124	histidyl-tRNA synthetase
A458_RS27260	COG2976	Protein conserved in bacteria
A458_RS27270	COG1160	GTP binding
A458_RS27280	COG0436	Aminotransferase
A458_RS27295	COG3647	Membrane
A458_RS27300	COG2356	endonuclease I
A458_RS27310	COG1064	alcohol dehydrogenase
A458_RS27315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A458_RS27330	COG0668	transmembrane transport
A458_RS27340	COG0739	heme binding
A458_RS27345	COG1570	exodeoxyribonuclease VII activity
A458_RS27360	COG0519	Catalyzes the synthesis of GMP from XMP
A458_RS27360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A458_RS27370	COG0590	tRNA wobble adenosine to inosine editing
A458_RS27375	COG3842	ATPase activity
A458_RS27385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A458_RS27395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A458_RS27400	COG0418	dihydroorotase activity
A458_RS27410	COG0137	argininosuccinate synthase activity
A458_RS27415	COG0346	lactoylglutathione lyase activity
A458_RS27425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A458_RS27435	COG4659	FMN binding
A458_RS27440	COG4658	electron transport chain
A458_RS27450	COG2878	Part of a membrane complex involved in electron transport
A458_RS27455	COG4657	Part of a membrane complex involved in electron transport
A458_RS27465	COG1024	Enoyl-CoA hydratase
A458_RS27470	COG1024	Enoyl-CoA hydratase
A458_RS27480	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A458_RS27495	COG0354	folic acid binding
A458_RS27530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A458_RS27535	COG0481	GTPase activity
A458_RS27550	COG0571	ribonuclease III activity
A458_RS27560	COG1381	Involved in DNA repair and RecF pathway recombination
A458_RS27565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A458_RS27575	COG0583	DNA-binding transcription factor activity
A458_RS27585	COG0500	methyltransferase
A458_RS27590	COG2226	methyltransferase
A458_RS27600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A458_RS27615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A458_RS27630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A458_RS27650	COG3039	Transposase
A458_RS27655	COG1414	Transcriptional regulator
A458_RS27660	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A458_RS27665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A458_RS27675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A458_RS27720	COG3039	Transposase
A458_RS27770	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
A458_RS27780	COG0583	DNA-binding transcription factor activity
A458_RS27785	COG1309	transcriptional regulator
A458_RS27795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A458_RS27800	COG1131	(ABC) transporter
A458_RS27805	COG0842	Transport permease protein
A458_RS27810	COG0842	Transport permease protein
A458_RS27825	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A458_RS27830	COG1611	Belongs to the LOG family
A458_RS27855	COG0583	DNA-binding transcription factor activity
A458_RS27915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A458_RS28000	COG1396	sequence-specific DNA binding
A458_RS28075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A458_RS28155	COG2003	Belongs to the UPF0758 family
A458_RS28250	COG0277	FAD linked oxidase domain protein
A458_RS28320	COG3039	Transposase
A458_RS28325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A458_RS28355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A458_RS28360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A458_RS28385	COG0789	Transcriptional regulator
A458_RS28420	COG3436	PFAM IS66 Orf2 family protein
A458_RS28440	COG3039	Transposase
A458_RS28495	COG0582	viral genome integration into host DNA
A458_RS28525	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A458_RS28585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A458_RS28640	COG1802	Transcriptional regulator
A458_RS28640	COG4626	Terminase
A458_RS28645	COG4695	Portal protein
A458_RS28650	COG0740	serine-type endopeptidase activity
A458_RS28755	COG2135	peptidase activity
A458_RS28770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A458_RS28770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A458_RS28775	COG0489	protein tyrosine kinase activity
A458_RS28780	COG1278	Cold shock
A458_RS28785	COG0717	Belongs to the dCTP deaminase family
A458_RS28790	COG3005	denitrification pathway
A458_RS28800	COG0243	molybdopterin cofactor binding
A458_RS28810	COG4459	periplasmic nitrate reductase
A458_RS28815	COG2814	Major facilitator Superfamily
A458_RS28820	COG3091	SprT-like family
A458_RS28840	COG0037	tRNA processing
A458_RS28845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A458_RS28875	COG1294	oxidase, subunit
A458_RS28895	COG0791	NLP P60 protein
A458_RS28900	COG0791	NLP P60 protein
A458_RS28915	COG4206	TonB-dependent receptor
A458_RS28930	COG1797	cobyrinic acid a,c-diamide synthase activity
A458_RS28935	COG0778	Nitroreductase
A458_RS28945	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A458_RS28955	COG1492	cobalamin metabolic process
A458_RS28975	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A458_RS28985	COG0251	oxidation-reduction process
A458_RS29010	COG2067	long-chain fatty acid transport protein
A458_RS29025	COG3100	YcgL domain-containing protein
A458_RS29035	COG2983	Belongs to the UPF0260 family
A458_RS29050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A458_RS29055	COG0527	aspartate kinase activity
A458_RS29060	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A458_RS29085	COG2239	Acts as a magnesium transporter
A458_RS29090	COG3630	sodium ion export across plasma membrane
A458_RS29095	COG5016	pyruvate
A458_RS29095	COG0511	ligase activity, forming carbon-carbon bonds
A458_RS29100	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A458_RS29165	COG1217	gtp-binding protein TYPA
A458_RS29175	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A458_RS29195	COG0835	chemotaxis
A458_RS29195	COG0784	Response regulator, receiver
A458_RS29200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A458_RS29205	COG1815	bacterial-type flagellum-dependent cell motility
A458_RS29225	COG4787	bacterial-type flagellum-dependent cell motility
A458_RS29230	COG4786	Flagellar basal body rod
A458_RS29235	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A458_RS29240	COG1706	bacterial-type flagellum-dependent cell motility
A458_RS29250	COG1256	bacterial-type flagellum assembly
A458_RS29260	COG1555	photosystem II stabilization
A458_RS29285	COG2199	diguanylate cyclase activity
A458_RS29285	COG2200	EAL domain
A458_RS29300	COG1362	aminopeptidase activity
A458_RS29310	COG0564	pseudouridine synthase activity
A458_RS29315	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A458_RS29320	COG2894	cell division
A458_RS29325	COG0850	regulation of cytokinetic process
A458_RS29330	COG1560	Kdo2-lipid A biosynthetic process
A458_RS29340	COG2853	Lipoprotein
A458_RS29355	COG3162	membrane
A458_RS29360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A458_RS29380	COG3089	Belongs to the UPF0270 family
A458_RS29390	COG1363	Peptidase, m42
A458_RS29395	COG0189	ligase activity
A458_RS29395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A458_RS29400	COG0367	asparagine synthase
A458_RS29410	COG1404	Belongs to the peptidase S8 family
A458_RS29410	COG4935	Belongs to the peptidase S8 family
A458_RS29420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A458_RS29430	COG4221	oxidoreductase activity
A458_RS29440	COG1201	RNA secondary structure unwinding
A458_RS29465	COG1187	pseudouridine synthase activity
A458_RS29475	COG2133	pyrroloquinoline quinone binding
A458_RS29480	COG4993	Dehydrogenase
A458_RS29485	COG2996	Protein conserved in bacteria
A458_RS29500	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A458_RS29550	COG0732	type I restriction modification DNA specificity domain
A458_RS29575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A458_RS29580	COG3039	Transposase
A458_RS29615	COG3284	Transcriptional regulator
A458_RS29630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A458_RS29640	COG1696	Membrane protein involved in D-alanine export
A458_RS29650	COG0745	RESPONSE REGULATOR receiver
A458_RS29655	COG0784	Response regulator, receiver
A458_RS29655	COG2198	Histidine kinase
A458_RS29655	COG5002	protein histidine kinase activity
A458_RS29675	COG1129	ABC transporter
A458_RS29695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A458_RS29705	COG1295	ribonuclease BN
A458_RS29730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A458_RS29735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A458_RS29740	COG0582	viral genome integration into host DNA
A458_RS29790	COG3039	Transposase
A458_RS29835	COG0789	Transcriptional regulator
A458_RS29845	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A458_RS29850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A458_RS29855	COG4983	Phage plasmid primase, P4 family domain protein
A458_RS29865	COG1546	Belongs to the CinA family
A458_RS29870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A458_RS29875	COG2137	regulation of response to DNA damage stimulus
A458_RS29885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A458_RS29890	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A458_RS29900	COG3148	PFAM DTW domain containing protein
A458_RS29905	COG0697	spore germination
A458_RS29915	COG0583	DNA-binding transcription factor activity
A458_RS29925	COG3012	SEC-C Motif Domain Protein
A458_RS29945	COG1199	ATP-dependent helicase activity
A458_RS29950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A458_RS29960	COG0259	pyridoxamine-phosphate oxidase activity
A458_RS29970	COG3133	Outer membrane lipoprotein
A458_RS29975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A458_RS29975	COG2111	Na H antiporter
A458_RS29980	COG1006	Multisubunit Na H antiporter MnhC subunit
A458_RS29985	COG0651	ATP synthesis coupled electron transport
A458_RS29990	COG1863	multisubunit Na H antiporter MnhE subunit
A458_RS29995	COG2212	antiporter activity
A458_RS30000	COG1320	monovalent cation:proton antiporter activity
A458_RS30005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A458_RS30010	COG0024	Methionine aminopeptidase
A458_RS30015	COG0052	Belongs to the universal ribosomal protein uS2 family
A458_RS30020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A458_RS30025	COG0528	UMP kinase activity
A458_RS30030	COG0233	cytoplasmic translational termination
A458_RS30035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A458_RS30045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A458_RS30055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A458_RS30070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A458_RS30075	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A458_RS30080	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A458_RS30085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A458_RS30095	COG0825	malonyl-CoA metabolic process
A458_RS30100	COG0037	tRNA processing
A458_RS30105	COG0504	CTP synthase activity
A458_RS30110	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A458_RS30115	COG0148	phosphopyruvate hydratase activity
A458_RS30125	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A458_RS30140	COG0583	DNA-binding transcription factor activity
A458_RS30145	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A458_RS30150	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A458_RS30155	COG1902	pentaerythritol trinitrate reductase activity
A458_RS30165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A458_RS30170	COG0585	pseudouridine synthase activity
A458_RS30175	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A458_RS30180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A458_RS30220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A458_RS30230	COG0589	response to stress
A458_RS30240	COG0217	transcriptional regulatory protein
A458_RS30255	COG2258	MOSC domain
A458_RS30270	COG0004	ammonium transporteR
A458_RS30290	COG0483	inositol monophosphate 1-phosphatase activity
A458_RS30320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A458_RS30345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A458_RS30365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A458_RS30380	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS30385	COG2814	Major facilitator Superfamily
A458_RS30395	COG0826	peptidase U32
A458_RS30400	COG3459	Glycosyltransferase 36 associated
A458_RS30450	COG1733	regulation of RNA biosynthetic process
A458_RS30455	COG0583	DNA-binding transcription factor activity
A458_RS30460	COG2249	NAD(P)H dehydrogenase (quinone) activity
A458_RS30485	COG2226	methyltransferase
A458_RS30495	COG2807	transmembrane transport
A458_RS30500	COG1846	Transcriptional regulator
A458_RS30515	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A458_RS30520	COG0583	DNA-binding transcription factor activity
A458_RS30530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A458_RS30535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A458_RS30535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A458_RS30540	COG0745	RESPONSE REGULATOR receiver
A458_RS30545	COG2205	protein histidine kinase activity
A458_RS30560	COG2937	Belongs to the GPAT DAPAT family
A458_RS30565	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A458_RS30595	COG1131	(ABC) transporter
A458_RS30610	COG1278	Cold shock
A458_RS30620	COG2226	methyltransferase
A458_RS30625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A458_RS30630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A458_RS30670	COG0513	Belongs to the DEAD box helicase family
A458_RS30685	COG0583	DNA-binding transcription factor activity
A458_RS30705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A458_RS30705	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A458_RS30710	COG2205	protein histidine kinase activity
A458_RS30710	COG0784	Response regulator, receiver
A458_RS30710	COG5002	protein histidine kinase activity
A458_RS30715	COG2860	membrane
A458_RS30730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A458_RS30735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A458_RS30740	COG3956	TIGRFAM MazG family protein
A458_RS30760	COG1201	RNA secondary structure unwinding
A458_RS30765	COG1793	dna ligase
A458_RS30780	COG0668	transmembrane transport
A458_RS30815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A458_RS30825	COG2988	succinylglutamate desuccinylase activity
A458_RS30830	COG1131	(ABC) transporter
A458_RS30835	COG0842	Transport permease protein
A458_RS30840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A458_RS30840	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A458_RS30850	COG2853	Lipoprotein
A458_RS30860	COG0745	RESPONSE REGULATOR receiver
A458_RS30870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A458_RS30905	COG2814	Major facilitator Superfamily
A458_RS30910	COG4948	Mandelate Racemase Muconate Lactonizing
A458_RS30925	COG3135	benzoate transporter
A458_RS30965	COG2056	Na+-H+ antiporter family
A458_RS30970	COG0628	permease
A458_RS30995	COG2153	protein acetylation
A458_RS31000	COG2850	peptidyl-arginine hydroxylation
A458_RS31010	COG2915	High frequency lysogenization protein hflD homolog
A458_RS31015	COG0482	sulfurtransferase activity
A458_RS31040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A458_RS31045	COG0542	response to heat
A458_RS31050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A458_RS31055	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A458_RS31060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A458_RS31065	COG0492	ferredoxin-NADP+ reductase activity
A458_RS31075	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A458_RS31080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A458_RS31085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A458_RS31090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A458_RS31095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A458_RS31095	COG1648	precorrin-2 dehydrogenase activity
A458_RS31115	COG1131	(ABC) transporter
A458_RS31145	COG3851	Histidine kinase
A458_RS31200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A458_RS31220	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS31230	COG4172	Belongs to the ABC transporter superfamily
A458_RS31235	COG4239	(ABC) transporter, permease
A458_RS31240	COG4174	ABC transporter (Permease)
A458_RS31250	COG4166	transmembrane transport
A458_RS31260	COG0741	lytic transglycosylase activity
A458_RS31260	COG1388	LysM domain
A458_RS31265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A458_RS31275	COG0328	RNA-DNA hybrid ribonuclease activity
A458_RS31280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A458_RS31290	COG1024	Enoyl-CoA hydratase
A458_RS31300	COG2816	NAD+ diphosphatase activity
A458_RS31305	COG0730	response to heat
A458_RS31315	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS31335	COG0616	signal peptide processing
A458_RS31340	COG0604	alcohol dehydrogenase
A458_RS31370	COG0515	serine threonine protein kinase
A458_RS31375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A458_RS31380	COG2223	nitrite transmembrane transporter activity
A458_RS31425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A458_RS31425	COG0316	Belongs to the HesB IscA family
A458_RS31430	COG2197	response regulator
A458_RS31435	COG3706	GGDEF domain
A458_RS31445	COG2323	membrane
A458_RS31460	COG0840	transmembrane signaling receptor activity
A458_RS31465	COG1968	undecaprenyl-diphosphatase activity
A458_RS31470	COG2267	carboxylic ester hydrolase activity
A458_RS31475	COG0488	(ABC) transporter
A458_RS31505	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A458_RS31510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A458_RS31515	COG3265	gluconokinase activity
A458_RS31520	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A458_RS31525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A458_RS31530	COG1609	Transcriptional regulator
A458_RS31545	COG1070	Carbohydrate kinase
A458_RS31565	COG1175	transmembrane transport
A458_RS31585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A458_RS31600	COG0729	surface antigen
A458_RS31605	COG2911	Protein conserved in bacteria
A458_RS31610	COG1115	amino acid carrier protein
A458_RS31625	COG0728	peptidoglycan biosynthetic process
A458_RS31635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A458_RS31640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A458_RS31675	COG0604	alcohol dehydrogenase
A458_RS31675	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS31675	COG3321	synthase
A458_RS31680	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS31700	COG0366	Alpha amylase catalytic
A458_RS31705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A458_RS31710	COG0392	lysyltransferase activity
A458_RS31715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A458_RS31720	COG3568	Endonuclease Exonuclease Phosphatase
A458_RS31730	COG0583	DNA-binding transcription factor activity
A458_RS31735	COG3384	dioxygenase
A458_RS31740	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS31745	COG3038	cytochrome b561
A458_RS31750	COG0739	heme binding
A458_RS31775	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A458_RS31780	COG0297	glycogen (starch) synthase activity
A458_RS31785	COG1058	Belongs to the CinA family
A458_RS31785	COG1546	Belongs to the CinA family
A458_RS31790	COG3264	Mechanosensitive ion channel
A458_RS31790	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A458_RS31795	COG3685	Protein conserved in bacteria
A458_RS31835	COG0583	DNA-binding transcription factor activity
A458_RS31845	COG1566	PFAM secretion protein HlyD family protein
A458_RS31905	COG0840	transmembrane signaling receptor activity
A458_RS31935	COG5642	Protein of unknown function (DUF2384)
A458_RS31960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A458_RS31965	COG1742	UPF0060 membrane protein
A458_RS31975	COG0431	NADPH-dependent FMN reductase
A458_RS31980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A458_RS31985	COG0640	Transcriptional regulator
A458_RS31990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A458_RS31995	COG2072	flavoprotein involved in K transport
A458_RS32000	COG0798	PFAM Bile acid sodium symporter
A458_RS32040	COG0322	excinuclease ABC activity
A458_RS32055	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A458_RS32060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A458_RS32075	COG0784	Response regulator, receiver
A458_RS32075	COG2205	protein histidine kinase activity
A458_RS32090	COG0535	radical SAM domain protein
A458_RS32100	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A458_RS32105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A458_RS32135	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A458_RS32145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A458_RS32155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A458_RS32160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A458_RS32170	COG0544	peptidyl-prolyl cis-trans isomerase activity
A458_RS32180	COG0714	Associated with various cellular activities
A458_RS32185	COG3256	nitric oxide reductase
A458_RS32190	COG2010	Cytochrome c
A458_RS32200	COG3039	Transposase
A458_RS32205	COG1846	Transcriptional regulator
A458_RS32210	COG1764	response to oxidative stress
A458_RS32235	COG2186	Transcriptional regulator
A458_RS32260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A458_RS32265	COG0215	cysteine-tRNA ligase activity
A458_RS32270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A458_RS32275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A458_RS32280	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A458_RS32315	COG0668	transmembrane transport
A458_RS32330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A458_RS32340	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A458_RS32355	COG0372	Belongs to the citrate synthase family
A458_RS32365	COG1802	Transcriptional regulator
A458_RS32390	COG0560	Phosphoserine phosphatase
A458_RS32405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A458_RS32410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A458_RS32440	COG4181	ATPase activity
A458_RS32445	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A458_RS32460	COG5380	lipid catabolic process
A458_RS32465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A458_RS32485	COG3842	ATPase activity
A458_RS32490	COG3665	Urea carboxylase-associated protein
A458_RS32500	COG4770	biotin carboxylase activity
A458_RS32510	COG0668	transmembrane transport
A458_RS32515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A458_RS32525	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS32545	COG1335	isochorismatase
A458_RS32560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A458_RS32565	COG1116	anion transmembrane transporter activity
A458_RS32570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A458_RS32630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A458_RS32635	COG0435	Glutathione S-transferase
A458_RS32640	COG0784	Response regulator, receiver
A458_RS32640	COG2205	protein histidine kinase activity
A458_RS32660	COG0789	Transcriptional regulator
A458_RS32675	COG0302	gtp cyclohydrolase
A458_RS32680	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A458_RS32700	COG1366	Belongs to the anti-sigma-factor antagonist family
A458_RS32705	COG5001	Diguanylate cyclase
A458_RS32710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A458_RS32715	COG1090	epimerase
A458_RS32720	COG3272	Protein of unknown function (DUF1722)
A458_RS32725	COG0789	Transcriptional regulator
A458_RS32730	COG0415	Belongs to the DNA photolyase family
A458_RS32740	COG4221	oxidoreductase activity
A458_RS32755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A458_RS32780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A458_RS32780	COG2146	nitrite reductase [NAD(P)H] activity
A458_RS32785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A458_RS32785	COG2146	nitrite reductase [NAD(P)H] activity
A458_RS32795	COG0515	serine threonine protein kinase
A458_RS32800	COG0210	DNA helicase
A458_RS32815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A458_RS32850	COG3447	MASE1 domain protein
A458_RS32850	COG5001	Diguanylate cyclase
A458_RS32850	COG5002	protein histidine kinase activity
A458_RS32860	COG0583	DNA-binding transcription factor activity
A458_RS32865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A458_RS32885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A458_RS32895	COG1253	flavin adenine dinucleotide binding
A458_RS32900	COG4991	sh3 domain protein
A458_RS32930	COG0058	SHG alpha-glucan phosphorylase activity
A458_RS32960	COG1024	Enoyl-CoA hydratase
A458_RS32965	COG1960	acyl-CoA dehydrogenase activity
A458_RS32975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A458_RS32985	COG1960	acyl-CoA dehydrogenase activity
A458_RS32990	COG0183	Belongs to the thiolase family
A458_RS33005	COG1238	metal cluster binding
A458_RS33025	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
A458_RS33050	COG0714	Associated with various cellular activities
A458_RS33060	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A458_RS33065	COG0709	Synthesizes selenophosphate from selenide and ATP
A458_RS33075	COG0628	permease
A458_RS33110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A458_RS33115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A458_RS33125	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A458_RS33190	COG0045	succinate-CoA ligase (ADP-forming) activity
A458_RS33210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A458_RS33215	COG1053	succinate dehydrogenase
A458_RS33220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A458_RS33225	COG2009	succinate dehydrogenase
A458_RS33265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A458_RS33275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A458_RS33280	COG3115	cell septum assembly
A458_RS33290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A458_RS33295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A458_RS33310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A458_RS33310	COG2010	Cytochrome c
A458_RS33315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A458_RS33335	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A458_RS33345	COG0840	transmembrane signaling receptor activity
A458_RS33355	COG3278	Belongs to the heme-copper respiratory oxidase family
A458_RS33365	COG2010	Cytochrome c
A458_RS33370	COG3278	Belongs to the heme-copper respiratory oxidase family
A458_RS33385	COG2010	Cytochrome c
A458_RS33415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A458_RS33425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A458_RS33445	COG0573	inorganic phosphate transmembrane transporter activity
A458_RS33460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A458_RS33465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A458_RS33470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A458_RS33475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A458_RS33490	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A458_RS33505	COG0446	pyridine nucleotide-disulphide oxidoreductase
A458_RS33505	COG1902	pentaerythritol trinitrate reductase activity
A458_RS33525	COG1294	oxidase, subunit
A458_RS33530	COG1271	oxidase subunit
A458_RS33555	COG0655	NAD(P)H dehydrogenase (quinone) activity
A458_RS33560	COG0583	DNA-binding transcription factor activity
A458_RS33605	COG1286	toxin biosynthetic process
A458_RS33615	COG0285	dihydrofolate synthase activity
A458_RS33620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A458_RS33625	COG0135	phosphoribosylanthranilate isomerase activity
A458_RS33650	COG0473	3-isopropylmalate dehydrogenase activity
A458_RS33655	COG0066	3-isopropylmalate dehydratase activity
A458_RS33660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A458_RS33675	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS33740	COG0250	Participates in transcription elongation, termination and antitermination
A458_RS33770	COG0297	glycogen (starch) synthase activity
A458_RS33785	COG1216	Glycosyl transferase, family 2
A458_RS33800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A458_RS33805	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A458_RS33810	COG1012	belongs to the aldehyde dehydrogenase family
A458_RS33815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A458_RS33820	COG0133	tryptophan synthase activity
A458_RS33870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A458_RS33905	COG0183	Belongs to the thiolase family
A458_RS33910	COG1250	3-hydroxyacyl-CoA dehydrogenase
A458_RS33910	COG1024	Enoyl-CoA hydratase
A458_RS33915	COG1770	oligopeptidase
A458_RS33925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A458_RS33935	COG0583	DNA-binding transcription factor activity
A458_RS33940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A458_RS33945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A458_RS33970	COG2301	Belongs to the HpcH HpaI aldolase family
A458_RS33980	COG2079	MmgE PrpD family protein
A458_RS33990	COG1960	acyl-CoA dehydrogenase activity
A458_RS33995	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
A458_RS34000	COG0583	DNA-binding transcription factor activity
A458_RS34025	COG0840	transmembrane signaling receptor activity
A458_RS34040	COG1054	Belongs to the UPF0176 family
A458_RS34045	COG0271	Belongs to the BolA IbaG family
A458_RS34055	COG0114	fumarate hydratase activity
A458_RS34090	COG0402	S-adenosylhomocysteine deaminase activity
A458_RS34095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A458_RS34100	COG0546	phosphoglycolate phosphatase activity
A458_RS34105	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS34115	COG0800	Aldolase
A458_RS34140	COG2840	Smr protein MutS2
A458_RS34145	COG0302	gtp cyclohydrolase
A458_RS34150	COG0625	glutathione transferase activity
A458_RS34155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A458_RS34170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A458_RS34175	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A458_RS34185	COG0077	Prephenate dehydratase
A458_RS34185	COG1605	Chorismate mutase
A458_RS34190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A458_RS34200	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A458_RS34215	COG0587	DNA-directed DNA polymerase activity
A458_RS34245	COG0535	radical SAM domain protein
A458_RS34250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A458_RS34265	COG4962	Type ii secretion system protein e
A458_RS34350	COG0776	regulation of translation
A458_RS34355	COG0072	phenylalanine-tRNA ligase activity
A458_RS34360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A458_RS34365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A458_RS34370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A458_RS34375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A458_RS34380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A458_RS34390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A458_RS34435	COG3039	Transposase
A458_RS34470	COG3171	Protein conserved in bacteria
A458_RS34475	COG2027	D-alanyl-D-alanine carboxypeptidase
A458_RS34480	COG0116	Belongs to the methyltransferase superfamily
A458_RS34480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A458_RS34490	COG0167	dihydroorotate dehydrogenase activity
A458_RS34510	COG0714	Associated with various cellular activities
A458_RS34530	COG2304	oxidoreductase activity
A458_RS34540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A458_RS34545	COG3707	response regulator
A458_RS34565	COG2223	nitrite transmembrane transporter activity
A458_RS34570	COG0515	serine threonine protein kinase
A458_RS34570	COG2815	serine threonine protein kinase
A458_RS34580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A458_RS34585	COG2146	nitrite reductase [NAD(P)H] activity
A458_RS34590	COG0243	molybdopterin cofactor binding
A458_RS34610	COG0308	aminopeptidase N
A458_RS34630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A458_RS34635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A458_RS34655	COG0583	DNA-binding transcription factor activity
A458_RS34670	COG1305	Transglutaminase-like
A458_RS34680	COG2308	Evidence 4 Homologs of previously reported genes of
A458_RS34685	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A458_RS34710	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A458_RS34715	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A458_RS34720	COG0235	Class ii aldolase
A458_RS34730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A458_RS34750	COG3842	ATPase activity
A458_RS34755	COG0395	ABC-type sugar transport system, permease component
A458_RS34760	COG1175	transmembrane transport
A458_RS34765	COG1653	transport
A458_RS34790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A458_RS34795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A458_RS34800	COG0180	Tryptophanyl-tRNA synthetase
A458_RS34805	COG0009	L-threonylcarbamoyladenylate synthase
A458_RS34810	COG0613	PHP domain protein
A458_RS34815	COG2350	Protein conserved in bacteria
A458_RS34825	COG0745	RESPONSE REGULATOR receiver
A458_RS34840	COG0778	Nitroreductase
A458_RS34845	COG0727	PFAM Uncharacterised protein family (UPF0153)
A458_RS34850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A458_RS34855	COG2354	Protein conserved in bacteria
A458_RS34890	COG1752	Esterase of the alpha-beta hydrolase superfamily
A458_RS34910	COG2832	Protein of unknown function (DUF454)
A458_RS34925	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A458_RS34935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A458_RS34945	COG0542	response to heat
A458_RS34965	COG0121	glutamine amidotransferase
A458_RS34975	COG0589	response to stress
A458_RS34985	COG0488	(ABC) transporter
A458_RS34990	COG0741	lytic transglycosylase activity
A458_RS34995	COG0633	Ferredoxin
A458_RS34995	COG3217	Mosc domain protein beta barrel domain protein
A458_RS35010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A458_RS35015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A458_RS35020	COG3206	protein involved in exopolysaccharide biosynthesis
A458_RS35020	COG0489	protein tyrosine kinase activity
A458_RS35025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A458_RS35065	COG0183	Belongs to the thiolase family
A458_RS35075	COG2977	Belongs to the P-Pant transferase superfamily
A458_RS35085	COG0776	regulation of translation
A458_RS35105	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A458_RS35110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A458_RS35125	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
A458_RS35150	COG4591	ABC-type transport system involved in lipoprotein release permease component
A458_RS35155	COG1136	(ABC) transporter
A458_RS35175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A458_RS35230	COG0386	Belongs to the glutathione peroxidase family
A458_RS35235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A458_RS35240	COG0436	Aminotransferase
A458_RS35250	COG0501	Belongs to the peptidase M48B family
A458_RS35260	COG0500	methyltransferase
A458_RS35310	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A458_RS35340	COG2257	FlhB HrpN YscU SpaS Family
A458_RS35355	COG0835	chemotaxis
A458_RS35365	COG1192	Involved in chromosome partitioning
A458_RS35370	COG1360	Flagellar Motor Protein
A458_RS35375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A458_RS35380	COG2201	protein-glutamate methylesterase activity
A458_RS35385	COG0643	Histidine kinase
A458_RS35385	COG0784	Response regulator, receiver
A458_RS35385	COG2198	Histidine kinase
A458_RS35390	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A458_RS35420	COG2032	superoxide dismutase activity
A458_RS35435	COG1987	bacterial-type flagellum assembly
A458_RS35475	COG0745	RESPONSE REGULATOR receiver
A458_RS35510	COG1677	Flagellar hook-basal body complex protein FliE
A458_RS35515	COG3135	benzoate transporter
A458_RS35525	COG2130	NADP-dependent
A458_RS35535	COG3300	MHYT domain
A458_RS35535	COG5001	Diguanylate cyclase
A458_RS35545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A458_RS35560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A458_RS35605	COG1113	amino acid transport
A458_RS35610	COG0084	hydrolase, TatD family'
A458_RS35625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A458_RS35630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A458_RS35640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A458_RS35645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A458_RS35675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A458_RS35675	COG0616	signal peptide processing
A458_RS35680	COG0546	phosphoglycolate phosphatase activity
A458_RS35690	COG1530	ribonuclease E activity
A458_RS35695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A458_RS35700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A458_RS35705	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A458_RS35710	COG2835	tetraacyldisaccharide 4'-kinase activity
A458_RS35715	COG1663	tetraacyldisaccharide 4'-kinase activity
A458_RS35725	COG0811	peptide transport
A458_RS35730	COG0658	competence protein
A458_RS35730	COG2333	competence protein COMEC
A458_RS35745	COG1136	(ABC) transporter
A458_RS35750	COG4591	ABC-type transport system involved in lipoprotein release permease component
A458_RS35765	COG0584	glycerophosphoryl diester phosphodiesterase
A458_RS35770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A458_RS35780	COG1477	protein flavinylation
A458_RS35790	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A458_RS35805	COG1805	sodium ion transport
A458_RS35820	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A458_RS35845	COG4989	oxidoreductase activity
A458_RS35855	COG0800	Aldolase
A458_RS35870	COG1737	Transcriptional regulator
A458_RS35890	COG2814	Major facilitator Superfamily
A458_RS35925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A458_RS35925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A458_RS35940	COG3154	lipid carrier protein
A458_RS35945	COG0826	peptidase U32
A458_RS35950	COG0826	peptidase U32
A458_RS35960	COG3604	Transcriptional regulator
A458_RS35975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A458_RS35990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A458_RS36005	COG0642	Histidine kinase
A458_RS36020	COG2217	Heavy metal translocating P-type atpase
A458_RS36030	COG2132	Multicopper oxidase
A458_RS36095	COG1346	cytolysis
A458_RS36100	COG1380	Effector of murein hydrolase LrgA
A458_RS36105	COG0348	domain, Protein
A458_RS36110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A458_RS36130	COG1309	transcriptional regulator
A458_RS36140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A458_RS36150	COG0742	ribosomal rna small subunit methyltransferase
A458_RS36175	COG0563	adenylate kinase activity
A458_RS36180	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A458_RS36220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A458_RS36240	COG1902	pentaerythritol trinitrate reductase activity
A458_RS36245	COG3383	formate dehydrogenase (NAD+) activity
A458_RS36250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A458_RS36260	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A458_RS36265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A458_RS36270	COG1984	allophanate hydrolase subunit 2
A458_RS36275	COG1914	H( )-stimulated, divalent metal cation uptake system
A458_RS36295	COG0545	Peptidyl-prolyl cis-trans isomerase
A458_RS36310	COG2974	May be involved in recombination
A458_RS36315	COG2814	Major facilitator Superfamily
A458_RS36335	COG2205	protein histidine kinase activity
A458_RS36340	COG3174	membrane
A458_RS36390	COG1196	nuclear chromosome segregation
A458_RS36400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A458_RS36410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A458_RS36415	COG2716	regulation of RNA biosynthetic process
A458_RS36420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A458_RS36430	COG0425	Belongs to the sulfur carrier protein TusA family
A458_RS36440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A458_RS36445	COG0427	acetyl-CoA hydrolase
A458_RS36455	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A458_RS36460	COG0602	queuosine metabolic process
A458_RS36465	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A458_RS36470	COG2885	chlorophyll binding
A458_RS36475	COG0823	Involved in the tonB-independent uptake of proteins
A458_RS36495	COG0824	Thioesterase
A458_RS36500	COG2255	four-way junction helicase activity
A458_RS36505	COG0632	four-way junction helicase activity
A458_RS36510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A458_RS36520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A458_RS36525	COG0783	Belongs to the Dps family
A458_RS36535	COG2900	Belongs to the SlyX family
A458_RS36550	COG0442	prolyl-tRNA aminoacylation
A458_RS36580	COG1295	ribonuclease BN
A458_RS36585	COG1393	Belongs to the ArsC family
A458_RS36600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A458_RS36605	COG0628	permease
A458_RS36615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A458_RS36620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A458_RS36635	COG0436	Aminotransferase
A458_RS36650	COG1393	Belongs to the ArsC family
A458_RS36655	COG2171	N-acyltransferase activity
A458_RS36660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A458_RS36675	COG3258	Cytochrome c
A458_RS36680	COG2863	cytochrome
A458_RS36695	COG3530	Putative quorum-sensing-regulated virulence factor
A458_RS36705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A458_RS36715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A458_RS36725	COG0583	DNA-binding transcription factor activity
A458_RS36730	COG4221	oxidoreductase activity
A458_RS36740	COG1280	lysine exporter protein (LysE YggA)
A458_RS36760	COG1462	curli production assembly transport component CsgG
A458_RS36780	COG1309	transcriptional regulator
A458_RS36790	COG0189	ligase activity
A458_RS36790	COG4067	protein conserved in archaea
A458_RS36805	COG4771	TonB-dependent receptor
A458_RS36810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A458_RS36815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A458_RS36820	COG1120	ATPase activity
A458_RS36835	COG3321	synthase
A458_RS36835	COG0604	alcohol dehydrogenase
A458_RS36855	COG0583	DNA-binding transcription factor activity
A458_RS36885	COG0625	glutathione transferase activity
A458_RS36940	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A458_RS36950	COG0784	Response regulator, receiver
A458_RS36950	COG4191	Histidine kinase
A458_RS36965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A458_RS36975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A458_RS36985	COG4221	oxidoreductase activity
A458_RS36995	COG2207	Transcriptional regulator
A458_RS37000	COG3845	ABC transporter
A458_RS37005	COG4603	Belongs to the binding-protein-dependent transport system permease family
A458_RS37010	COG1079	Belongs to the binding-protein-dependent transport system permease family
A458_RS37030	COG1301	dicarboxylic acid transport
A458_RS37040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A458_RS37055	COG0490	domain, Protein
A458_RS37055	COG0471	metal ion transport
A458_RS37085	COG2814	Major facilitator Superfamily
A458_RS37115	COG1279	arginine transmembrane transporter activity
A458_RS37135	COG2733	membrane
A458_RS37140	COG1116	anion transmembrane transporter activity
A458_RS37155	COG0537	adenosine 5'-monophosphoramidase activity
A458_RS37175	COG3795	YCII-related domain
A458_RS37190	COG1234	tRNA 3'-trailer cleavage
A458_RS37210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A458_RS37215	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A458_RS37220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A458_RS37225	COG2205	protein histidine kinase activity
A458_RS37230	COG0631	protein serine/threonine phosphatase activity
A458_RS37235	COG0515	serine threonine protein kinase
A458_RS37235	COG2815	serine threonine protein kinase
A458_RS37250	COG1643	Atp-dependent helicase
A458_RS37270	COG0318	PFAM AMP-dependent synthetase and ligase
A458_RS37275	COG0318	PFAM AMP-dependent synthetase and ligase
A458_RS37280	COG2030	dehydratase
A458_RS37305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A458_RS37315	COG0443	Heat shock 70 kDa protein
A458_RS37320	COG2271	Major facilitator Superfamily
A458_RS37325	COG3622	Belongs to the hyi family
A458_RS37330	COG2084	Dehydrogenase
A458_RS37335	COG1968	undecaprenyl-diphosphatase activity
A458_RS37345	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A458_RS37355	COG3639	organic phosphonate transmembrane transporter activity
A458_RS37360	COG3639	organic phosphonate transmembrane transporter activity
A458_RS37430	COG2165	general secretion pathway protein
A458_RS37440	COG2165	general secretion pathway protein
A458_RS37445	COG1459	type II secretion system
A458_RS37460	COG3409	Peptidoglycan-binding domain 1 protein
A458_RS37460	COG3267	Type II secretory pathway component ExeA
A458_RS37490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A458_RS37525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A458_RS37530	COG0556	nucleotide-excision repair
A458_RS37560	COG3791	Glutathione-dependent formaldehyde-activating
A458_RS37570	COG4974	Belongs to the 'phage' integrase family
A458_RS37575	COG0335	large ribosomal subunit rRNA binding
A458_RS37580	COG0336	Belongs to the RNA methyltransferase TrmD family
A458_RS37585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A458_RS37590	COG0228	four-way junction DNA binding
A458_RS37595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A458_RS37600	COG4137	Cytochrome C assembly protein
A458_RS37605	COG4536	flavin adenine dinucleotide binding
A458_RS37610	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A458_RS37635	COG3034	peptidoglycan biosynthetic process
A458_RS37645	COG0047	phosphoribosylformylglycinamidine synthase activity
A458_RS37645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A458_RS37650	COG1126	abc transporter atp-binding protein
A458_RS37655	COG0765	amino acid transport
A458_RS37660	COG4597	amino acid ABC transporter
A458_RS37665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A458_RS37670	COG0400	carboxylic ester hydrolase activity
A458_RS37685	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A458_RS37690	COG0315	cyclic pyranopterin monophosphate synthase activity
A458_RS37695	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A458_RS37700	COG1230	cation diffusion facilitator family transporter
A458_RS37705	COG3022	response to hydroperoxide
A458_RS37720	COG0433	COG0433 Predicted ATPase
A458_RS37730	COG0788	formyltetrahydrofolate deformylase activity
A458_RS37740	COG2925	Exonuclease
A458_RS37765	COG0714	Associated with various cellular activities
A458_RS37800	COG3706	GGDEF domain
A458_RS37815	COG4628	conserved protein (DUF2132)
A458_RS37820	COG0693	protein deglycase activity
A458_RS37825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A458_RS37870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A458_RS37885	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A458_RS37895	COG1309	transcriptional regulator
A458_RS37900	COG0386	Belongs to the glutathione peroxidase family
A458_RS37910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A458_RS37920	COG0204	Acyl-transferase
A458_RS37930	COG0784	Response regulator, receiver
A458_RS37930	COG2205	protein histidine kinase activity
A458_RS37935	COG2885	chlorophyll binding
A458_RS37940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A458_RS37945	COG0318	PFAM AMP-dependent synthetase and ligase
A458_RS37950	COG1280	lysine exporter protein (LysE YggA)
A458_RS37955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A458_RS37960	COG2813	Specifically methylates the guanine in position
A458_RS37965	COG2119	membrane
A458_RS37975	COG0501	Belongs to the peptidase M48B family
A458_RS37980	COG0840	transmembrane signaling receptor activity
A458_RS38035	COG0659	secondary active sulfate transmembrane transporter activity
A458_RS38040	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS38065	COG1285	pathogenesis
A458_RS38110	COG1181	Belongs to the D-alanine--D-alanine ligase family
A458_RS38115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A458_RS38120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A458_RS38125	COG0772	Belongs to the SEDS family
A458_RS38130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A458_RS38135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A458_RS38140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A458_RS38145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A458_RS38160	COG0275	rRNA processing
A458_RS38175	COG3107	peptidoglycan biosynthetic process
A458_RS38180	COG0792	nuclease activity
A458_RS38185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A458_RS38190	COG2823	Periplasmic or secreted lipoprotein
A458_RS38195	COG2969	positive regulation of protein catabolic process
A458_RS38200	COG0625	glutathione transferase activity
A458_RS38205	COG2857	Cytochrome c1
A458_RS38210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A458_RS38215	COG0723	plastoquinol--plastocyanin reductase activity
A458_RS38220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A458_RS38225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A458_RS38230	COG0667	Aldo Keto reductase
A458_RS38240	COG0237	dephospho-CoA kinase activity
A458_RS38245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A458_RS38280	COG1131	(ABC) transporter
A458_RS38285	COG2755	lipolytic protein G-D-S-L family
A458_RS38285	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A458_RS38295	COG0175	sulfate reduction
A458_RS38305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A458_RS38310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A458_RS38320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A458_RS38325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A458_RS38350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A458_RS38355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A458_RS38360	COG1127	ABC transporter
A458_RS38370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A458_RS38385	COG1137	ATPase activity
A458_RS38390	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A458_RS38405	COG1660	Displays ATPase and GTPase activities
A458_RS38415	COG0312	modulator of DNA gyrase
A458_RS38425	COG0312	modulator of DNA gyrase
A458_RS38430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A458_RS38440	COG1530	ribonuclease E activity
A458_RS38460	COG1792	Involved in formation and maintenance of cell shape
A458_RS38465	COG1077	Cell shape determining protein MreB Mrl
A458_RS38480	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A458_RS38485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A458_RS38495	COG0530	calcium, potassium:sodium antiporter activity
A458_RS38510	COG0739	heme binding
A458_RS38520	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A458_RS38535	COG4771	TonB-dependent receptor
A458_RS38555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A458_RS38560	COG4774	siderophore transport
A458_RS38565	COG3128	pkhd-type hydroxylase
A458_RS38575	COG0019	diaminopimelate decarboxylase activity
A458_RS38580	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A458_RS38585	COG2852	Protein conserved in bacteria
A458_RS38590	COG4993	Dehydrogenase
A458_RS38595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A458_RS38595	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A458_RS38595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A458_RS38600	COG1105	Belongs to the carbohydrate kinase PfkB family
A458_RS38605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A458_RS38605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A458_RS38620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A458_RS38650	COG0534	Mate efflux family protein
A458_RS38660	COG1166	arginine decarboxylase activity
A458_RS38665	COG0023	Translation Initiation Factor
A458_RS38670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A458_RS38710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A458_RS38715	COG1047	Peptidyl-prolyl cis-trans
A458_RS38720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A458_RS38725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A458_RS38730	COG0196	riboflavin kinase activity
A458_RS38735	COG0728	peptidoglycan biosynthetic process
A458_RS38740	COG0268	Binds directly to 16S ribosomal RNA
A458_RS38745	COG3045	CreA protein
A458_RS38750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A458_RS38755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A458_RS38760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A458_RS38765	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A458_RS38770	COG0142	geranyltranstransferase activity
A458_RS38780	COG0545	Peptidyl-prolyl cis-trans isomerase
A458_RS38785	COG3046	protein related to deoxyribodipyrimidine photolyase
A458_RS38795	COG2862	Uncharacterized protein family, UPF0114
A458_RS38805	COG1067	ATP-dependent peptidase activity
A458_RS38815	COG1970	mechanosensitive ion channel activity
A458_RS38845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A458_RS38850	COG0488	(ABC) transporter
A458_RS38885	COG2813	Specifically methylates the guanine in position
A458_RS38890	COG0789	Transcriptional regulator
A458_RS38900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A458_RS38905	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A458_RS38910	COG2080	2 iron, 2 sulfur cluster binding
A458_RS38920	COG3608	succinylglutamate desuccinylase aspartoacylase
A458_RS38920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A458_RS38930	COG2252	PERMEase
A458_RS38935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A458_RS38940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A458_RS38985	COG3642	lipopolysaccharide core region biosynthetic process
A458_RS38995	COG0642	Histidine kinase
A458_RS39000	COG0745	RESPONSE REGULATOR receiver
A458_RS39005	COG1368	sulfuric ester hydrolase activity
A458_RS39035	COG0318	PFAM AMP-dependent synthetase and ligase
A458_RS39065	COG3038	cytochrome b561
A458_RS39070	COG0303	'Molybdopterin
A458_RS39075	COG0521	Mo-molybdopterin cofactor biosynthetic process
A458_RS39090	COG2181	nitrate reductase activity
A458_RS39095	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A458_RS39100	COG1140	nitrate reductase beta subunit
A458_RS39105	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A458_RS39110	COG2223	nitrite transmembrane transporter activity
A458_RS39120	COG2223	nitrite transmembrane transporter activity
A458_RS39125	COG3850	Histidine kinase
A458_RS39130	COG2197	response regulator
A458_RS39155	COG2321	neutral zinc metallopeptidase
A458_RS39165	COG1946	Acyl-CoA thioesterase
A458_RS39175	COG0123	including yeast histone deacetylase and acetoin utilization protein
A458_RS39195	COG0513	Belongs to the DEAD box helicase family
A458_RS39200	COG4651	solute:proton antiporter activity
A458_RS39200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A458_RS39220	COG0733	neurotransmitter:sodium symporter activity
A458_RS39225	COG0625	glutathione transferase activity
A458_RS39235	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A458_RS39245	COG0733	neurotransmitter:sodium symporter activity
A458_RS39260	COG1522	sequence-specific DNA binding
A458_RS39270	COG2031	fatty acid transporter
A458_RS39275	COG2610	gluconate transmembrane transporter activity
A458_RS39280	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS39285	COG1040	competence protein
A458_RS39295	COG2031	fatty acid transporter
A458_RS39300	COG4829	muconolactone delta-isomerase
A458_RS39315	COG1028	Short-chain dehydrogenase reductase Sdr
A458_RS39320	COG0564	pseudouridine synthase activity
A458_RS39370	COG0420	3'-5' exonuclease activity
A458_RS39380	COG4206	TonB-dependent receptor
A458_RS39395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A458_RS39400	COG3577	Aspartyl protease
A458_RS39405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A458_RS39410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A458_RS39415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A458_RS39420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A458_RS39435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A458_RS39435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A458_RS39450	COG2264	protein methyltransferase activity
A458_RS39460	COG0425	Belongs to the sulfur carrier protein TusA family
A458_RS39465	COG2391	methyltransferase activity
A458_RS39470	COG3118	belongs to the thioredoxin family
A458_RS39485	COG4181	ATPase activity
A458_RS39510	COG0848	biopolymer transport protein
A458_RS39515	COG0811	peptide transport
A458_RS39520	COG0811	peptide transport
A458_RS39530	COG3047	cAMP biosynthetic process
A458_RS39555	COG5290	Psort location Cytoplasmic, score
A458_RS39575	COG1073	alpha beta
A458_RS39590	COG0656	L-ascorbic acid biosynthetic process
A458_RS39595	COG0667	Aldo Keto reductase
A458_RS39615	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A458_RS39615	COG3608	succinylglutamate desuccinylase aspartoacylase
A458_RS39620	COG2080	2 iron, 2 sulfur cluster binding
A458_RS39625	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A458_RS39630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A458_RS39635	COG0667	Aldo Keto reductase
A458_RS39655	COG2135	peptidase activity
A458_RS39675	COG1061	Type III restriction enzyme res subunit
A458_RS39720	COG2814	Major facilitator Superfamily
A458_RS39735	COG0753	catalase activity
A458_RS39740	COG0203	ribosomal protein L17
A458_RS39745	COG0202	RNA polymerase activity
A458_RS39750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A458_RS39755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A458_RS39760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A458_RS39765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A458_RS39775	COG0200	Binds to the 23S rRNA
A458_RS39780	COG1841	ribosomal large subunit assembly
A458_RS39785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A458_RS39795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A458_RS39800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A458_RS39805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A458_RS39810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A458_RS39815	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A458_RS39820	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A458_RS39825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A458_RS39830	COG0255	Belongs to the universal ribosomal protein uL29 family
A458_RS39835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A458_RS39840	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A458_RS39845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A458_RS39850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A458_RS39855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A458_RS39860	COG0089	rRNA binding
A458_RS39865	COG0088	Forms part of the polypeptide exit tunnel
A458_RS39870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A458_RS39875	COG0051	transcription antitermination factor activity, RNA binding
A458_RS39880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A458_RS39885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A458_RS39890	COG0049	tRNA binding
A458_RS39895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A458_RS39900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A458_RS39905	COG0085	RNA polymerase activity
A458_RS39910	COG0222	ribosome binding
A458_RS39920	COG0081	regulation of translation
A458_RS39925	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A458_RS39945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A458_RS39970	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A458_RS39975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A458_RS39975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A458_RS40010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A458_RS40015	COG0739	heme binding
A458_RS40020	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A458_RS40025	COG0316	Belongs to the HesB IscA family
A458_RS40030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A458_RS40035	COG1981	membrane
A458_RS40045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A458_RS40050	COG0537	adenosine 5'-monophosphoramidase activity
A458_RS40055	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A458_RS40065	COG1765	OsmC-like protein
A458_RS40075	COG0134	indole-3-glycerol-phosphate synthase activity
A458_RS40080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A458_RS40085	COG0512	Glutamine amidotransferase of anthranilate synthase
A458_RS40095	COG0546	phosphoglycolate phosphatase activity
A458_RS40100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A458_RS40110	COG0659	secondary active sulfate transmembrane transporter activity
A458_RS40115	COG1454	alcohol dehydrogenase
A458_RS40125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A458_RS40140	COG1176	ABC-type spermidine putrescine transport system, permease component I
A458_RS40150	COG3842	ATPase activity
A458_RS40155	COG2197	response regulator
A458_RS40170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A458_RS40175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A458_RS40185	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A458_RS40190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A458_RS40195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A458_RS40200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A458_RS40205	COG2967	ApaG domain
A458_RS40210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A458_RS40215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A458_RS40220	COG2766	serine protein kinase
A458_RS40225	COG2718	Belongs to the UPF0229 family
A458_RS40230	COG2719	SpoVR family
A458_RS40250	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A458_RS40255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A458_RS40260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A458_RS40265	COG0358	DNA primase activity
A458_RS40270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A458_RS40340	COG0471	metal ion transport
A458_RS40340	COG3273	potassium ion transport
A458_RS40345	COG2873	o-acetylhomoserine
A458_RS40350	COG3118	belongs to the thioredoxin family
A458_RS40375	COG0583	DNA-binding transcription factor activity
A458_RS40380	COG2814	Major facilitator Superfamily
A458_RS40390	COG0493	'glutamate synthase
A458_RS40395	COG0069	glutamate synthase activity
A458_RS40395	COG0067	glutamate synthase
A458_RS40395	COG0070	glutamate synthase
A458_RS40405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A458_RS40410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A458_RS40445	COG0281	malic enzyme
A458_RS40455	COG0254	rRNA binding
A458_RS40460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A458_RS40465	COG0018	arginyl-trna synthetase
A458_RS40480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A458_RS40495	COG0248	Ppx GppA phosphatase
A458_RS40500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A458_RS40510	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A458_RS40525	COG1671	Belongs to the UPF0178 family
A458_RS40530	COG1280	lysine exporter protein (LysE YggA)
A458_RS40535	COG0861	Integral membrane protein TerC family
A458_RS40545	COG0488	(ABC) transporter
A458_RS40565	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A458_RS40595	COG3275	phosphorelay sensor kinase activity
A458_RS40600	COG0165	Argininosuccinate lyase
A458_RS40605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A458_RS40645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A458_RS40650	COG1965	Belongs to the frataxin family
A458_RS40665	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A458_RS40675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A458_RS40690	COG0432	Pfam Uncharacterised protein family UPF0047
A458_RS40695	COG0004	ammonium transporteR
A458_RS40700	COG0004	ammonium transporteR
A458_RS40705	COG0347	Belongs to the P(II) protein family
A458_RS40715	COG0606	chelatase, subunit chli
A458_RS40720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A458_RS40730	COG0210	DNA helicase
A458_RS40735	COG1272	protein, Hemolysin III
A458_RS40740	COG1414	Transcriptional regulator
A458_RS40750	COG1454	alcohol dehydrogenase
A458_RS40760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A458_RS40765	COG0366	Alpha amylase catalytic
A458_RS40780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A458_RS40805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A458_RS40815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A458_RS40820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A458_RS40835	COG0840	transmembrane signaling receptor activity
A458_RS40840	COG1250	3-hydroxyacyl-CoA dehydrogenase
A458_RS40855	COG2003	Belongs to the UPF0758 family
A458_RS40860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A458_RS40865	COG0756	dUTP diphosphatase activity
A458_RS40875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A458_RS40890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A458_RS40895	COG0708	Exodeoxyribonuclease III
A458_RS40905	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A458_RS40910	COG1561	YicC-like family, N-terminal region
A458_RS40920	COG1758	RNA polymerase activity
A458_RS40925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A458_RS40950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A458_RS40970	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A458_RS40975	COG1704	LemA family
A458_RS40980	COG0583	DNA-binding transcription factor activity
A458_RS40985	COG0604	alcohol dehydrogenase
A458_RS40995	COG1960	acyl-CoA dehydrogenase activity
A458_RS41000	COG0583	DNA-binding transcription factor activity
A458_RS41025	COG1620	l-lactate permease
A458_RS41030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A458_RS41035	COG3193	protein, possibly involved in utilization of glycolate and propanediol
A458_RS41040	COG0247	lactate metabolic process
A458_RS41045	COG0277	FAD linked oxidase domain protein
A458_RS41050	COG0277	FAD linked oxidase domain protein
A458_RS41055	COG2186	Transcriptional regulator
A458_RS41060	COG3161	chorismate lyase activity
A458_RS41065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A458_RS41080	COG1253	flavin adenine dinucleotide binding
A458_RS41090	COG0739	heme binding
A458_RS41110	COG0411	ABC transporter
A458_RS41120	COG0559	Belongs to the binding-protein-dependent transport system permease family
A458_RS41130	COG1192	Involved in chromosome partitioning
A458_RS41135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A458_RS41140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A458_RS41145	COG0730	response to heat
A458_RS41160	COG0494	nUDIX hydrolase
A458_RS41175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A458_RS41180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A458_RS41200	COG0179	Fumarylacetoacetate (FAA) hydrolase
A458_RS41205	COG0277	FAD linked oxidase domain protein
A458_RS41210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A458_RS41235	COG2197	response regulator
A458_RS41280	COG0651	ATP synthesis coupled electron transport
A458_RS41285	COG1007	ATP synthesis coupled electron transport
A458_RS41300	COG1320	monovalent cation:proton antiporter activity
A458_RS41325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A458_RS41330	COG5001	Diguanylate cyclase
A458_RS41355	COG4807	Protein conserved in bacteria
A458_RS41360	COG2204	response regulator
A458_RS41385	COG5001	Diguanylate cyclase
A458_RS41385	COG4251	negative regulation of phosphorylation
A458_RS41385	COG3706	GGDEF domain
A458_RS41385	COG2203	Gaf domain
A458_RS41400	COG2207	Transcriptional regulator
A458_RS41415	COG2819	hydrolase of the alpha beta superfamily
A458_RS41430	COG4565	transcriptional regulatory protein
A458_RS41435	COG3290	protein histidine kinase activity
A458_RS41440	COG3493	citrate carrier protein
A458_RS41455	COG1217	gtp-binding protein TYPA
A458_RS41460	COG0301	tRNA thio-modification
A458_RS41460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A458_RS41480	COG3852	Histidine kinase
A458_RS41500	COG0243	molybdopterin cofactor binding
A458_RS41510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A458_RS41525	COG2226	methyltransferase
A458_RS41535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A458_RS41540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A458_RS41545	COG0140	phosphoribosyl-ATP diphosphatase activity
A458_RS41550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A458_RS41555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A458_RS41575	COG1490	D-aminoacyl-tRNA deacylase activity
A458_RS41605	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A458_RS41610	COG0058	SHG alpha-glucan phosphorylase activity
A458_RS41625	COG1218	3'(2'),5'-bisphosphate nucleotidase
A458_RS41630	COG0494	nUDIX hydrolase
A458_RS41635	COG1011	Hydrolase
A458_RS41640	COG4191	Histidine kinase
A458_RS41640	COG0784	Response regulator, receiver
A458_RS41660	COG1454	alcohol dehydrogenase
A458_RS41665	COG1960	acyl-CoA dehydrogenase activity
A458_RS41670	COG1024	Enoyl-CoA hydratase
A458_RS41670	COG1250	3-hydroxyacyl-CoA dehydrogenase
A458_RS41680	COG1366	Belongs to the anti-sigma-factor antagonist family
A458_RS41685	COG1366	Belongs to the anti-sigma-factor antagonist family
A458_RS41690	COG2172	sigma factor antagonist activity
A458_RS41700	COG2205	protein histidine kinase activity
A458_RS41705	COG4191	Histidine kinase
A458_RS41705	COG0784	Response regulator, receiver
A458_RS41710	COG1278	Cold shock
A458_RS41740	COG0667	Aldo Keto reductase
A458_RS41750	COG0840	transmembrane signaling receptor activity
A458_RS41755	COG0840	transmembrane signaling receptor activity
A458_RS41760	COG0514	ATP-dependent DNA helicase (RecQ)
A458_RS41765	COG0778	Nitroreductase
A458_RS41775	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A458_RS41780	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A458_RS41785	COG4067	protein conserved in archaea
A458_RS41785	COG0189	ligase activity
A458_RS41790	COG0189	ligase activity
A458_RS41820	COG2194	sulfuric ester hydrolase activity
A458_RS41830	COG1192	Involved in chromosome partitioning
A458_RS41835	COG1215	transferase activity, transferring glycosyl groups
A458_RS41840	COG1215	transferase activity, transferring glycosyl groups
A458_RS41845	COG3118	belongs to the thioredoxin family
A458_RS41845	COG0457	Tetratricopeptide repeat
A458_RS41850	COG2183	response to ionizing radiation
A458_RS41860	COG2918	glutathione biosynthetic process
A458_RS41875	COG0306	phosphate transporter
A458_RS41880	COG1392	Phosphate transport regulator
A458_RS41890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A458_RS41900	COG2989	Protein conserved in bacteria
A458_RS41915	COG1764	response to oxidative stress
A458_RS41920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A458_RS41930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A458_RS41980	COG0582	viral genome integration into host DNA
A458_RS41985	COG2814	Major facilitator Superfamily
A458_RS42010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A458_RS42020	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A458_RS42040	COG2258	MOSC domain
A458_RS42045	COG0436	Aminotransferase
A458_RS42050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A458_RS42080	COG2205	protein histidine kinase activity
A458_RS42085	COG1082	Xylose isomerase domain protein TIM barrel
A458_RS42085	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A458_RS42095	COG0583	DNA-binding transcription factor activity
A458_RS42105	COG1301	dicarboxylic acid transport
A458_RS42130	COG1115	amino acid carrier protein
A458_RS42135	COG0252	asparaginase activity
A458_RS42150	COG2066	Belongs to the glutaminase family
A458_RS42165	COG5016	pyruvate
A458_RS42165	COG0511	ligase activity, forming carbon-carbon bonds
A458_RS42170	COG0439	Biotin carboxylase
A458_RS42175	COG0583	DNA-binding transcription factor activity
A458_RS42185	COG1737	Transcriptional regulator
A458_RS42185	COG0837	glucose binding
A458_RS42190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A458_RS42200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A458_RS42205	COG1917	Cupin 2, conserved barrel domain protein
A458_RS42210	COG5285	phytanoyl-CoA dioxygenase
A458_RS42215	COG0527	aspartate kinase activity
A458_RS42220	COG2841	Protein conserved in bacteria
A458_RS42225	COG0826	peptidase U32
A458_RS42235	COG0210	DNA helicase
A458_RS42240	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A458_RS42255	COG1764	response to oxidative stress
A458_RS42275	COG0437	4 iron, 4 sulfur cluster binding
A458_RS42280	COG2864	formate dehydrogenase
A458_RS42285	COG3058	Necessary for formate dehydrogenase activity
A458_RS42290	COG1921	L-seryl-tRNASec selenium transferase activity
A458_RS42295	COG3276	selenocysteine insertion sequence binding
A458_RS42300	COG1278	Cold shock
A458_RS42320	COG0509	glycine decarboxylation via glycine cleavage system
A458_RS42330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A458_RS42335	COG0589	response to stress
A458_RS42340	COG0659	secondary active sulfate transmembrane transporter activity
A458_RS42355	COG2204	response regulator
A458_RS42360	COG4941	Belongs to the sigma-70 factor family
A458_RS42365	COG3795	YCII-related domain
A458_RS42390	COG0784	Response regulator, receiver
A458_RS42390	COG4191	Histidine kinase
A458_RS42395	COG1960	acyl-CoA dehydrogenase activity
A458_RS42400	COG2706	6-phosphogluconolactonase activity
A458_RS42415	COG2264	protein methyltransferase activity
A458_RS42440	COG0583	DNA-binding transcription factor activity
A458_RS42445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A458_RS42515	COG2249	NAD(P)H dehydrogenase (quinone) activity
A458_RS42525	COG2207	Transcriptional regulator
A458_RS42595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A458_RS42605	COG4589	Belongs to the CDS family
A458_RS42610	COG1611	Belongs to the LOG family
A458_RS42625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A458_RS42630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A458_RS42635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A458_RS42640	COG0318	PFAM AMP-dependent synthetase and ligase
A458_RS42660	COG2814	Major facilitator Superfamily
A458_RS42665	COG1960	acyl-CoA dehydrogenase activity
A458_RS42670	COG1960	acyl-CoA dehydrogenase activity
A458_RS42675	COG1024	Enoyl-CoA hydratase
A458_RS42675	COG1250	3-hydroxyacyl-CoA dehydrogenase
A458_RS42690	COG3909	cytochrome
A458_RS42695	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
A458_RS42750	COG3179	chitinase
A458_RS42760	COG2010	Cytochrome c
A458_RS42765	COG0753	catalase activity
A458_RS42770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A458_RS42775	COG1127	ABC transporter
A458_RS42790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A458_RS42795	COG1129	ABC transporter
A458_RS42795	COG0842	Transport permease protein
A458_RS42800	COG0842	Transport permease protein
A458_RS42870	COG4771	TonB-dependent receptor
A458_RS42885	COG1116	anion transmembrane transporter activity
A458_RS42895	COG1177	transmembrane transport
A458_RS42900	COG1176	ABC-type spermidine putrescine transport system, permease component I
A458_RS42905	COG3842	ATPase activity
A458_RS42925	COG0174	glutamine synthetase
A458_RS42930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A458_RS42935	COG0174	glutamine synthetase
A458_RS42950	COG2957	Belongs to the agmatine deiminase family
A458_RS42970	COG3706	GGDEF domain
A458_RS42985	COG0745	RESPONSE REGULATOR receiver
A458_RS42990	COG5002	protein histidine kinase activity
A458_RS42995	COG0745	RESPONSE REGULATOR receiver
A458_RS43005	COG5002	protein histidine kinase activity
A458_RS43005	COG0784	Response regulator, receiver
A458_RS43005	COG2205	protein histidine kinase activity
A458_RS43010	COG0745	RESPONSE REGULATOR receiver
A458_RS43030	COG1012	belongs to the aldehyde dehydrogenase family
A458_RS43035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A458_RS43045	COG0735	belongs to the Fur family
A458_RS43050	COG1121	(ABC) transporter
A458_RS43055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A458_RS43060	COG1451	nucleotide metabolic process
A458_RS43065	COG0471	metal ion transport
A458_RS43080	COG2011	ABC-type metal ion transport system permease component
A458_RS43100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A458_RS43105	COG0339	signal peptide processing
A458_RS43140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A458_RS43145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A458_RS43150	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A458_RS43175	COG1612	heme a metabolic process
A458_RS43180	COG0109	protoheme IX farnesyltransferase activity
A458_RS43205	COG1595	DNA-templated transcription, initiation
A458_RS43220	COG0523	cobalamin synthesis protein
A458_RS43235	COG4251	negative regulation of phosphorylation
A458_RS43240	COG0784	Response regulator, receiver
A458_RS43245	COG0784	Response regulator, receiver
A458_RS43245	COG4191	Histidine kinase
A458_RS43300	COG4221	oxidoreductase activity
A458_RS43340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A458_RS43375	COG3039	Transposase
A458_RS43405	COG0789	Transcriptional regulator
A458_RS43460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A458_RS43460	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A458_RS43505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A458_RS43510	COG1349	DNA-binding transcription factor activity
A458_RS43515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A458_RS43520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A458_RS43525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A458_RS43530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A458_RS43535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A458_RS43540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A458_RS43545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A458_RS43555	COG0356	it plays a direct role in the translocation of protons across the membrane
A458_RS43560	COG3312	ion transport
A458_RS43565	COG1475	DNA binding
A458_RS43570	COG1192	Involved in chromosome partitioning
A458_RS43575	COG0357	Ribosomal RNA small subunit methyltransferase G
A458_RS43580	COG0445	tRNA wobble uridine modification
A458_RS43585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A458_RS43590	COG0706	membrane insertase activity
A458_RS43595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A458_RS43600	COG0594	ribonuclease P activity
A458_RS44065	COG0651	ATP synthesis coupled electron transport
A458_RS44080	COG0583	DNA-binding transcription factor activity
A458_RS44375	COG4890	Cyd operon protein YbgT
A458_RS44430	COG0720	synthase
A458_RS44450	COG0653	protein targeting
A458_RS44495	COG3130	regulation of translation
A458_RS44515	COG0416	fatty acid biosynthetic process
A458_RS44520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A458_RS44635	COG2813	Specifically methylates the guanine in position
A458_RS44715	COG1401	restriction endodeoxyribonuclease activity
A458_RS44715	COG1401	restriction endodeoxyribonuclease activity
A458_RS45045	COG3486	L-lysine 6-monooxygenase (NADPH) activity