locus-tag	class	description
KCX70_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KCX70_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KCX70_RS00035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KCX70_RS00040	COG0751	glycine-tRNA ligase activity
KCX70_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
KCX70_RS00050	COG2818	Glycosylase
KCX70_RS00055	COG1560	Kdo2-lipid A biosynthetic process
KCX70_RS00065	COG0392	lysyltransferase activity
KCX70_RS00065	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KCX70_RS00080	COG1126	abc transporter atp-binding protein
KCX70_RS00085	COG0765	amino acid transport
KCX70_RS00090	COG0765	amino acid transport
KCX70_RS00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KCX70_RS00100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KCX70_RS00105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KCX70_RS00110	COG2423	ornithine cyclodeaminase activity
KCX70_RS00115	COG0006	proline dipeptidase activity
KCX70_RS00120	COG3608	succinylglutamate desuccinylase aspartoacylase
KCX70_RS00125	COG1522	sequence-specific DNA binding
KCX70_RS00130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KCX70_RS00135	COG1012	belongs to the aldehyde dehydrogenase family
KCX70_RS00140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KCX70_RS00145	COG0569	domain protein
KCX70_RS00150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KCX70_RS00155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KCX70_RS00160	COG0242	peptide deformylase activity
KCX70_RS00165	COG1652	LysM domain
KCX70_RS00170	COG0758	DNA mediated transformation
KCX70_RS00175	COG0009	L-threonylcarbamoyladenylate synthase
KCX70_RS00185	COG0408	coproporphyrinogen oxidase activity
KCX70_RS00190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KCX70_RS00205	COG1686	Belongs to the peptidase S11 family
KCX70_RS00215	COG0604	alcohol dehydrogenase
KCX70_RS00320	COG1132	(ABC) transporter
KCX70_RS00335	COG5339	Protein conserved in bacteria
KCX70_RS00340	COG0737	Belongs to the 5'-nucleotidase family
KCX70_RS00340	COG1525	nuclease
KCX70_RS00340	COG4085	toxin activity
KCX70_RS00355	COG0625	glutathione transferase activity
KCX70_RS00360	COG0667	Aldo Keto reductase
KCX70_RS00365	COG0656	L-ascorbic acid biosynthetic process
KCX70_RS00380	COG0159	tryptophan synthase activity
KCX70_RS00395	COG1404	Belongs to the peptidase S8 family
KCX70_RS00420	COG1132	(ABC) transporter
KCX70_RS00425	COG4249	Peptidase C14 caspase catalytic subunit p20
KCX70_RS00430	COG3360	Dodecin
KCX70_RS00440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KCX70_RS00480	COG4208	sulfate ABC transporter
KCX70_RS00490	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KCX70_RS00510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KCX70_RS00515	COG2207	Transcriptional regulator
KCX70_RS00525	COG0339	signal peptide processing
KCX70_RS00555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KCX70_RS00560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KCX70_RS00565	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KCX70_RS00595	COG0109	protoheme IX farnesyltransferase activity
KCX70_RS00610	COG2011	ABC-type metal ion transport system permease component
KCX70_RS00620	COG1451	nucleotide metabolic process
KCX70_RS00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KCX70_RS00630	COG1121	(ABC) transporter
KCX70_RS00635	COG0735	belongs to the Fur family
KCX70_RS00640	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KCX70_RS00655	COG1611	Belongs to the LOG family
KCX70_RS00705	COG2249	NAD(P)H dehydrogenase (quinone) activity
KCX70_RS00775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KCX70_RS00780	COG0583	DNA-binding transcription factor activity
KCX70_RS00825	COG2271	Major facilitator Superfamily
KCX70_RS00840	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KCX70_RS00845	COG1684	flagellar biosynthetic protein fliR
KCX70_RS00850	COG1987	bacterial-type flagellum assembly
KCX70_RS00885	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KCX70_RS00940	COG1191	sigma factor activity
KCX70_RS00945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KCX70_RS00965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KCX70_RS00980	COG1558	bacterial-type flagellum-dependent cell motility
KCX70_RS00985	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KCX70_RS00995	COG4787	bacterial-type flagellum-dependent cell motility
KCX70_RS01000	COG4786	Flagellar basal body rod
KCX70_RS01005	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KCX70_RS01010	COG1706	bacterial-type flagellum-dependent cell motility
KCX70_RS01015	COG0741	lytic transglycosylase activity
KCX70_RS01020	COG1256	bacterial-type flagellum assembly
KCX70_RS01020	COG4786	Flagellar basal body rod
KCX70_RS01035	COG2706	6-phosphogluconolactonase activity
KCX70_RS01050	COG3795	YCII-related domain
KCX70_RS01055	COG4941	Belongs to the sigma-70 factor family
KCX70_RS01070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KCX70_RS01080	COG1609	Transcriptional regulator
KCX70_RS01085	COG2204	response regulator
KCX70_RS01100	COG0659	secondary active sulfate transmembrane transporter activity
KCX70_RS01105	COG0589	response to stress
KCX70_RS01110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KCX70_RS01120	COG4974	Belongs to the 'phage' integrase family
KCX70_RS01200	COG3276	selenocysteine insertion sequence binding
KCX70_RS01205	COG1921	L-seryl-tRNASec selenium transferase activity
KCX70_RS01215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KCX70_RS01220	COG0210	DNA helicase
KCX70_RS01225	COG3300	MHYT domain
KCX70_RS01225	COG5001	Diguanylate cyclase
KCX70_RS01230	COG0826	peptidase U32
KCX70_RS01245	COG0527	aspartate kinase activity
KCX70_RS01250	COG5285	phytanoyl-CoA dioxygenase
KCX70_RS01255	COG1917	Cupin 2, conserved barrel domain protein
KCX70_RS01260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KCX70_RS01270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KCX70_RS01275	COG0837	glucose binding
KCX70_RS01275	COG1737	Transcriptional regulator
KCX70_RS01285	COG0583	DNA-binding transcription factor activity
KCX70_RS01290	COG0439	Biotin carboxylase
KCX70_RS01295	COG5016	pyruvate
KCX70_RS01295	COG0511	ligase activity, forming carbon-carbon bonds
KCX70_RS01305	COG2066	Belongs to the glutaminase family
KCX70_RS01330	COG0058	SHG alpha-glucan phosphorylase activity
KCX70_RS01335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
KCX70_RS01365	COG1490	D-aminoacyl-tRNA deacylase activity
KCX70_RS01385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KCX70_RS01390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KCX70_RS01395	COG0140	phosphoribosyl-ATP diphosphatase activity
KCX70_RS01400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KCX70_RS01405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KCX70_RS01415	COG2226	methyltransferase
KCX70_RS01430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KCX70_RS01440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KCX70_RS01455	COG3852	Histidine kinase
KCX70_RS01475	COG0301	tRNA thio-modification
KCX70_RS01475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KCX70_RS01480	COG1217	gtp-binding protein TYPA
KCX70_RS01490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KCX70_RS01495	COG0581	inorganic phosphate transmembrane transporter activity
KCX70_RS01500	COG0573	inorganic phosphate transmembrane transporter activity
KCX70_RS01505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KCX70_RS01530	COG2203	Gaf domain
KCX70_RS01530	COG4251	negative regulation of phosphorylation
KCX70_RS01530	COG5001	Diguanylate cyclase
KCX70_RS01530	COG3706	GGDEF domain
KCX70_RS01545	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KCX70_RS01555	COG4807	Protein conserved in bacteria
KCX70_RS01570	COG2204	response regulator
KCX70_RS01575	COG5001	Diguanylate cyclase
KCX70_RS01610	COG4589	Belongs to the CDS family
KCX70_RS01640	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS01680	COG2197	response regulator
KCX70_RS01700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KCX70_RS01705	COG0277	FAD linked oxidase domain protein
KCX70_RS01710	COG0179	Fumarylacetoacetate (FAA) hydrolase
KCX70_RS01725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KCX70_RS01730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KCX70_RS01745	COG0494	nUDIX hydrolase
KCX70_RS01750	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
KCX70_RS01760	COG0730	response to heat
KCX70_RS01765	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KCX70_RS01770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KCX70_RS01775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KCX70_RS01780	COG1192	Involved in chromosome partitioning
KCX70_RS01790	COG0559	Belongs to the binding-protein-dependent transport system permease family
KCX70_RS01800	COG0411	ABC transporter
KCX70_RS01815	COG0739	heme binding
KCX70_RS01825	COG1253	flavin adenine dinucleotide binding
KCX70_RS01840	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KCX70_RS01845	COG3161	chorismate lyase activity
KCX70_RS01850	COG2186	Transcriptional regulator
KCX70_RS01855	COG0277	FAD linked oxidase domain protein
KCX70_RS01860	COG0277	FAD linked oxidase domain protein
KCX70_RS01865	COG0247	lactate metabolic process
KCX70_RS01870	COG3193	protein, possibly involved in utilization of glycolate and propanediol
KCX70_RS01875	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KCX70_RS01880	COG1620	l-lactate permease
KCX70_RS01920	COG0583	DNA-binding transcription factor activity
KCX70_RS01925	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS01935	COG1704	LemA family
KCX70_RS01940	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KCX70_RS01950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KCX70_RS01970	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KCX70_RS01980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KCX70_RS01985	COG1758	RNA polymerase activity
KCX70_RS01995	COG1561	YicC-like family, N-terminal region
KCX70_RS02000	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KCX70_RS02010	COG0708	Exodeoxyribonuclease III
KCX70_RS02015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KCX70_RS02025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KCX70_RS02035	COG0756	dUTP diphosphatase activity
KCX70_RS02040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KCX70_RS02045	COG2003	Belongs to the UPF0758 family
KCX70_RS02055	COG2050	protein possibly involved in aromatic compounds catabolism
KCX70_RS02060	COG1250	3-hydroxyacyl-CoA dehydrogenase
KCX70_RS02080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KCX70_RS02085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KCX70_RS02095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KCX70_RS02120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KCX70_RS02135	COG0366	Alpha amylase catalytic
KCX70_RS02150	COG1454	alcohol dehydrogenase
KCX70_RS02160	COG1414	Transcriptional regulator
KCX70_RS02165	COG0210	DNA helicase
KCX70_RS02175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KCX70_RS02180	COG0606	chelatase, subunit chli
KCX70_RS02185	COG2960	long-chain fatty acid transporting porin activity
KCX70_RS02190	COG0347	Belongs to the P(II) protein family
KCX70_RS02195	COG0004	ammonium transporteR
KCX70_RS02200	COG0004	ammonium transporteR
KCX70_RS02205	COG0432	Pfam Uncharacterised protein family UPF0047
KCX70_RS02220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KCX70_RS02230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KCX70_RS02245	COG1965	Belongs to the frataxin family
KCX70_RS02250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KCX70_RS02270	COG0598	Magnesium transport protein CorA
KCX70_RS02280	COG2084	Dehydrogenase
KCX70_RS02290	COG0165	Argininosuccinate lyase
KCX70_RS02295	COG3275	phosphorelay sensor kinase activity
KCX70_RS02305	COG0181	hydroxymethylbilane synthase activity
KCX70_RS02325	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KCX70_RS02345	COG0488	(ABC) transporter
KCX70_RS02355	COG0861	Integral membrane protein TerC family
KCX70_RS02360	COG1280	lysine exporter protein (LysE YggA)
KCX70_RS02365	COG1671	Belongs to the UPF0178 family
KCX70_RS02370	COG2050	protein possibly involved in aromatic compounds catabolism
KCX70_RS02375	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
KCX70_RS02385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KCX70_RS02405	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KCX70_RS02420	COG0018	arginyl-trna synthetase
KCX70_RS02425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KCX70_RS02430	COG0254	rRNA binding
KCX70_RS02440	COG0281	malic enzyme
KCX70_RS02475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KCX70_RS02480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KCX70_RS02490	COG0067	glutamate synthase
KCX70_RS02490	COG0069	glutamate synthase activity
KCX70_RS02490	COG0070	glutamate synthase
KCX70_RS02495	COG0493	'glutamate synthase
KCX70_RS02515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KCX70_RS02520	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS02560	COG2986	histidine ammonia-lyase
KCX70_RS02585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KCX70_RS02590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KCX70_RS02605	COG3118	belongs to the thioredoxin family
KCX70_RS02610	COG0471	metal ion transport
KCX70_RS02610	COG3273	potassium ion transport
KCX70_RS02620	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KCX70_RS02670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KCX70_RS02675	COG0358	DNA primase activity
KCX70_RS02680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KCX70_RS02685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KCX70_RS02690	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KCX70_RS02710	COG2719	SpoVR family
KCX70_RS02715	COG2718	Belongs to the UPF0229 family
KCX70_RS02720	COG2766	serine protein kinase
KCX70_RS02725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KCX70_RS02730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KCX70_RS02735	COG2967	ApaG domain
KCX70_RS02740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KCX70_RS02745	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KCX70_RS02750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KCX70_RS02755	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KCX70_RS02760	COG3178	'Phosphotransferase
KCX70_RS02765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KCX70_RS02770	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KCX70_RS02785	COG2197	response regulator
KCX70_RS02790	COG3842	ATPase activity
KCX70_RS02800	COG1176	ABC-type spermidine putrescine transport system, permease component I
KCX70_RS02815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KCX70_RS02820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KCX70_RS02825	COG0546	phosphoglycolate phosphatase activity
KCX70_RS02840	COG0512	Glutamine amidotransferase of anthranilate synthase
KCX70_RS02845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KCX70_RS02850	COG0134	indole-3-glycerol-phosphate synthase activity
KCX70_RS02860	COG1765	OsmC-like protein
KCX70_RS02870	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KCX70_RS02875	COG0537	adenosine 5'-monophosphoramidase activity
KCX70_RS02890	COG1981	membrane
KCX70_RS02895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KCX70_RS02900	COG0316	Belongs to the HesB IscA family
KCX70_RS02905	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KCX70_RS02910	COG0739	heme binding
KCX70_RS02915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KCX70_RS02945	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KCX70_RS02945	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KCX70_RS02950	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KCX70_RS03000	COG0081	regulation of translation
KCX70_RS03015	COG0085	RNA polymerase activity
KCX70_RS03020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KCX70_RS03025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KCX70_RS03030	COG0049	tRNA binding
KCX70_RS03035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KCX70_RS03040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KCX70_RS03045	COG0051	transcription antitermination factor activity, RNA binding
KCX70_RS03050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KCX70_RS03055	COG0088	Forms part of the polypeptide exit tunnel
KCX70_RS03060	COG0089	rRNA binding
KCX70_RS03065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KCX70_RS03070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KCX70_RS03075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KCX70_RS03080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KCX70_RS03085	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KCX70_RS03090	COG0255	Belongs to the universal ribosomal protein uL29 family
KCX70_RS03095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KCX70_RS03100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KCX70_RS03105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KCX70_RS03110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KCX70_RS03115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KCX70_RS03120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KCX70_RS03125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KCX70_RS03135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KCX70_RS03140	COG1841	ribosomal large subunit assembly
KCX70_RS03145	COG0200	Binds to the 23S rRNA
KCX70_RS03155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KCX70_RS03160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KCX70_RS03165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KCX70_RS03170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KCX70_RS03175	COG0202	RNA polymerase activity
KCX70_RS03180	COG0203	ribosomal protein L17
KCX70_RS03195	COG2814	Major facilitator Superfamily
KCX70_RS03215	COG3047	cAMP biosynthetic process
KCX70_RS03225	COG0811	peptide transport
KCX70_RS03230	COG0811	peptide transport
KCX70_RS03235	COG0848	biopolymer transport protein
KCX70_RS03275	COG2321	neutral zinc metallopeptidase
KCX70_RS03285	COG3038	cytochrome b561
KCX70_RS03290	COG0642	Histidine kinase
KCX70_RS03350	COG0642	Histidine kinase
KCX70_RS03360	COG3642	lipopolysaccharide core region biosynthetic process
KCX70_RS03380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KCX70_RS03385	COG2252	PERMEase
KCX70_RS03390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KCX70_RS03390	COG3608	succinylglutamate desuccinylase aspartoacylase
KCX70_RS03400	COG2080	2 iron, 2 sulfur cluster binding
KCX70_RS03405	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
KCX70_RS03410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KCX70_RS03425	COG0789	Transcriptional regulator
KCX70_RS03430	COG2813	Specifically methylates the guanine in position
KCX70_RS03445	COG0583	DNA-binding transcription factor activity
KCX70_RS03450	COG3119	arylsulfatase activity
KCX70_RS03490	COG4176	ABC-type proline glycine betaine transport system permease component
KCX70_RS03495	COG4175	Glycine betaine
KCX70_RS03500	COG1760	l-serine dehydratase
KCX70_RS03520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KCX70_RS03525	COG0247	lactate metabolic process
KCX70_RS03525	COG2181	nitrate reductase activity
KCX70_RS03530	COG0446	pyridine nucleotide-disulphide oxidoreductase
KCX70_RS03530	COG1902	pentaerythritol trinitrate reductase activity
KCX70_RS03550	COG1063	alcohol dehydrogenase
KCX70_RS03580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KCX70_RS03585	COG1017	nitric oxide dioxygenase activity
KCX70_RS03585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KCX70_RS03595	COG3265	gluconokinase activity
KCX70_RS03620	COG0488	(ABC) transporter
KCX70_RS03630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KCX70_RS03670	COG1970	mechanosensitive ion channel activity
KCX70_RS03675	COG1067	ATP-dependent peptidase activity
KCX70_RS03685	COG2862	Uncharacterized protein family, UPF0114
KCX70_RS03690	COG0545	Peptidyl-prolyl cis-trans isomerase
KCX70_RS03700	COG0142	geranyltranstransferase activity
KCX70_RS03705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KCX70_RS03710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KCX70_RS03715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KCX70_RS03720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KCX70_RS03725	COG3045	CreA protein
KCX70_RS03730	COG0268	Binds directly to 16S ribosomal RNA
KCX70_RS03735	COG0728	peptidoglycan biosynthetic process
KCX70_RS03740	COG0196	riboflavin kinase activity
KCX70_RS03745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KCX70_RS03750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KCX70_RS03755	COG1047	Peptidyl-prolyl cis-trans
KCX70_RS03760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KCX70_RS03805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KCX70_RS03810	COG0023	Translation Initiation Factor
KCX70_RS03815	COG1166	arginine decarboxylase activity
KCX70_RS03820	COG2824	Alkylphosphonate utilization operon protein PhnA
KCX70_RS03825	COG1607	acyl-coa hydrolase
KCX70_RS03835	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
KCX70_RS03850	COG0420	3'-5' exonuclease activity
KCX70_RS03875	COG3212	peptidase
KCX70_RS03905	COG0028	Belongs to the TPP enzyme family
KCX70_RS03910	COG0564	pseudouridine synthase activity
KCX70_RS03915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KCX70_RS03930	COG1522	sequence-specific DNA binding
KCX70_RS03945	COG0733	neurotransmitter:sodium symporter activity
KCX70_RS03950	COG0625	glutathione transferase activity
KCX70_RS03955	COG0733	neurotransmitter:sodium symporter activity
KCX70_RS03980	COG2154	pterin-4-alpha-carbinolamine dehydratase
KCX70_RS04000	COG1760	l-serine dehydratase
KCX70_RS04005	COG0492	ferredoxin-NADP+ reductase activity
KCX70_RS04015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KCX70_RS04030	COG3189	MarR family transcriptional regulator
KCX70_RS04045	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS04050	COG3901	Regulator of nitric oxide reductase transcription
KCX70_RS04050	COG0348	domain, Protein
KCX70_RS04055	COG4263	nitrous-oxide reductase activity
KCX70_RS04070	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KCX70_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS04100	COG4109	DRTGG domain
KCX70_RS04120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KCX70_RS04120	COG1648	precorrin-2 dehydrogenase activity
KCX70_RS04125	COG0535	radical SAM domain protein
KCX70_RS04155	COG3391	amine dehydrogenase activity
KCX70_RS04160	COG2010	Cytochrome c
KCX70_RS04175	COG0714	Associated with various cellular activities
KCX70_RS04180	COG1845	cytochrome c oxidase, subunit III
KCX70_RS04190	COG2010	Cytochrome c
KCX70_RS04195	COG3256	nitric oxide reductase
KCX70_RS04210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KCX70_RS04225	COG3604	Transcriptional regulator
KCX70_RS04235	COG0826	peptidase U32
KCX70_RS04240	COG0826	peptidase U32
KCX70_RS04245	COG3154	lipid carrier protein
KCX70_RS04295	COG2814	Major facilitator Superfamily
KCX70_RS04315	COG1012	belongs to the aldehyde dehydrogenase family
KCX70_RS04320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KCX70_RS04345	COG1280	lysine exporter protein (LysE YggA)
KCX70_RS04350	COG1942	4-Oxalocrotonate Tautomerase
KCX70_RS04405	COG0753	catalase activity
KCX70_RS04415	COG0534	Mate efflux family protein
KCX70_RS04445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KCX70_RS04460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KCX70_RS04460	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KCX70_RS04465	COG1105	Belongs to the carbohydrate kinase PfkB family
KCX70_RS04470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KCX70_RS04470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KCX70_RS04470	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KCX70_RS04475	COG4993	Dehydrogenase
KCX70_RS04490	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KCX70_RS04505	COG3128	pkhd-type hydroxylase
KCX70_RS04510	COG4774	siderophore transport
KCX70_RS04515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KCX70_RS04545	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KCX70_RS04555	COG0530	calcium, potassium:sodium antiporter activity
KCX70_RS04560	COG0530	calcium, potassium:sodium antiporter activity
KCX70_RS04565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KCX70_RS04570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KCX70_RS04580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KCX70_RS04585	COG1077	Cell shape determining protein MreB Mrl
KCX70_RS04590	COG1792	Involved in formation and maintenance of cell shape
KCX70_RS04605	COG1530	ribonuclease E activity
KCX70_RS04615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KCX70_RS04620	COG0312	modulator of DNA gyrase
KCX70_RS04630	COG0312	modulator of DNA gyrase
KCX70_RS04640	COG1660	Displays ATPase and GTPase activities
KCX70_RS04655	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KCX70_RS04660	COG1137	ATPase activity
KCX70_RS04665	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KCX70_RS04675	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KCX70_RS04685	COG1127	ABC transporter
KCX70_RS04690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KCX70_RS04695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KCX70_RS04720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KCX70_RS04725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KCX70_RS04740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KCX70_RS04765	COG1131	(ABC) transporter
KCX70_RS04800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KCX70_RS04805	COG0237	dephospho-CoA kinase activity
KCX70_RS04820	COG0667	Aldo Keto reductase
KCX70_RS04825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KCX70_RS04830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KCX70_RS04835	COG0723	plastoquinol--plastocyanin reductase activity
KCX70_RS04840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KCX70_RS04845	COG2857	Cytochrome c1
KCX70_RS04850	COG0625	glutathione transferase activity
KCX70_RS04855	COG2969	positive regulation of protein catabolic process
KCX70_RS04860	COG2823	Periplasmic or secreted lipoprotein
KCX70_RS04865	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KCX70_RS04870	COG0792	nuclease activity
KCX70_RS04875	COG3107	peptidoglycan biosynthetic process
KCX70_RS04895	COG0275	rRNA processing
KCX70_RS04910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KCX70_RS04915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KCX70_RS04920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KCX70_RS04925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KCX70_RS04930	COG0772	Belongs to the SEDS family
KCX70_RS04935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KCX70_RS04940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KCX70_RS04945	COG1181	Belongs to the D-alanine--D-alanine ligase family
KCX70_RS04960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KCX70_RS04965	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KCX70_RS04985	COG0679	Auxin Efflux Carrier
KCX70_RS05000	COG2124	cytochrome p450
KCX70_RS05010	COG0151	Belongs to the GarS family
KCX70_RS05015	COG0138	bifunctional purine biosynthesis protein purh
KCX70_RS05025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KCX70_RS05035	COG2264	protein methyltransferase activity
KCX70_RS05050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KCX70_RS05065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KCX70_RS05070	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KCX70_RS05100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KCX70_RS05110	COG3098	single-species biofilm formation
KCX70_RS05120	COG0028	Belongs to the TPP enzyme family
KCX70_RS05130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KCX70_RS05135	COG1183	phosphatidylcholine synthase activity
KCX70_RS05145	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
KCX70_RS05190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KCX70_RS05200	COG0456	acetyltransferase
KCX70_RS05210	COG1877	trehalose-phosphatase activity
KCX70_RS05220	COG0288	reversible hydration of carbon dioxide
KCX70_RS05265	COG0656	L-ascorbic acid biosynthetic process
KCX70_RS05270	COG2814	Major facilitator Superfamily
KCX70_RS05275	COG0583	DNA-binding transcription factor activity
KCX70_RS05285	COG1408	metallophosphoesterase
KCX70_RS05305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KCX70_RS05325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KCX70_RS05330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KCX70_RS05340	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KCX70_RS05345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KCX70_RS05355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KCX70_RS05360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KCX70_RS05380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KCX70_RS05385	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KCX70_RS05425	COG0653	protein targeting
KCX70_RS05430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KCX70_RS05435	COG0494	nUDIX hydrolase
KCX70_RS05470	COG2096	Adenosyltransferase
KCX70_RS05475	COG4191	Histidine kinase
KCX70_RS05485	COG0745	RESPONSE REGULATOR receiver
KCX70_RS05490	COG1666	GTP binding
KCX70_RS05495	COG0668	transmembrane transport
KCX70_RS05505	COG3695	enzyme binding
KCX70_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS05525	COG3030	protein affecting phage T7 exclusion by the F plasmid
KCX70_RS05530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KCX70_RS05535	COG0459	protein refolding
KCX70_RS05545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KCX70_RS05550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KCX70_RS05595	COG1309	transcriptional regulator
KCX70_RS05605	COG0840	transmembrane signaling receptor activity
KCX70_RS05615	COG2233	PERMEase
KCX70_RS05625	COG2233	PERMEase
KCX70_RS05635	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
KCX70_RS05640	COG4266	Belongs to the allantoicase family
KCX70_RS05665	COG2252	PERMEase
KCX70_RS05670	COG1802	Transcriptional regulator
KCX70_RS05675	COG0402	S-adenosylhomocysteine deaminase activity
KCX70_RS05745	COG3639	organic phosphonate transmembrane transporter activity
KCX70_RS05755	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
KCX70_RS05775	COG2084	Dehydrogenase
KCX70_RS05780	COG3622	Belongs to the hyi family
KCX70_RS05785	COG2271	Major facilitator Superfamily
KCX70_RS05790	COG0443	Heat shock 70 kDa protein
KCX70_RS05815	COG0513	Belongs to the DEAD box helicase family
KCX70_RS05845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KCX70_RS05865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KCX70_RS05890	COG2030	dehydratase
KCX70_RS05895	COG0318	PFAM AMP-dependent synthetase and ligase
KCX70_RS05900	COG0318	PFAM AMP-dependent synthetase and ligase
KCX70_RS05915	COG1643	Atp-dependent helicase
KCX70_RS05925	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS05940	COG1234	tRNA 3'-trailer cleavage
KCX70_RS05945	COG0730	response to heat
KCX70_RS05970	COG5001	Diguanylate cyclase
KCX70_RS05970	COG3300	MHYT domain
KCX70_RS05980	COG3795	YCII-related domain
KCX70_RS05990	COG0625	glutathione transferase activity
KCX70_RS06000	COG0537	adenosine 5'-monophosphoramidase activity
KCX70_RS06020	COG2733	membrane
KCX70_RS06045	COG0490	domain, Protein
KCX70_RS06045	COG0471	metal ion transport
KCX70_RS06065	COG2814	Major facilitator Superfamily
KCX70_RS06070	COG0667	Aldo Keto reductase
KCX70_RS06080	COG3530	Putative quorum-sensing-regulated virulence factor
KCX70_RS06105	COG0583	DNA-binding transcription factor activity
KCX70_RS06110	COG3932	Exopolysaccharide synthesis, ExoD
KCX70_RS06115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KCX70_RS06120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KCX70_RS06125	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KCX70_RS06140	COG1968	undecaprenyl-diphosphatase activity
KCX70_RS06145	COG3081	Nucleoid-associated protein
KCX70_RS06165	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
KCX70_RS06170	COG0477	Major facilitator Superfamily
KCX70_RS06180	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KCX70_RS06200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KCX70_RS06205	COG0795	lipopolysaccharide-transporting ATPase activity
KCX70_RS06210	COG0795	lipopolysaccharide-transporting ATPase activity
KCX70_RS06220	COG1278	Cold shock
KCX70_RS06230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KCX70_RS06240	COG1862	Preprotein translocase
KCX70_RS06255	COG3134	Outer membrane lipoprotein
KCX70_RS06280	COG1104	cysteine desulfurase activity
KCX70_RS06290	COG0316	Belongs to the HesB IscA family
KCX70_RS06295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KCX70_RS06300	COG0443	Heat shock 70 kDa protein
KCX70_RS06315	COG0105	UTP biosynthetic process
KCX70_RS06320	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KCX70_RS06330	COG1426	Protein conserved in bacteria
KCX70_RS06335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KCX70_RS06340	COG0124	histidyl-tRNA synthetase
KCX70_RS06345	COG2976	Protein conserved in bacteria
KCX70_RS06355	COG1160	GTP binding
KCX70_RS06365	COG0436	Aminotransferase
KCX70_RS06375	COG3647	Membrane
KCX70_RS06380	COG2356	endonuclease I
KCX70_RS06390	COG1064	alcohol dehydrogenase
KCX70_RS06395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KCX70_RS06410	COG0668	transmembrane transport
KCX70_RS06415	COG1335	isochorismatase
KCX70_RS06420	COG0739	heme binding
KCX70_RS06425	COG1570	exodeoxyribonuclease VII activity
KCX70_RS06440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KCX70_RS06440	COG0519	Catalyzes the synthesis of GMP from XMP
KCX70_RS06445	COG0582	viral genome integration into host DNA
KCX70_RS06470	COG0156	8-amino-7-oxononanoate synthase activity
KCX70_RS06485	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KCX70_RS06490	COG0511	ligase activity, forming carbon-carbon bonds
KCX70_RS06490	COG5016	pyruvate
KCX70_RS06505	COG3039	Transposase
KCX70_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS06540	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS06545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KCX70_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS06600	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KCX70_RS06630	COG1024	Enoyl-CoA hydratase
KCX70_RS06635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KCX70_RS06640	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS06645	COG0789	Transcriptional regulator
KCX70_RS06655	COG0386	Belongs to the glutathione peroxidase family
KCX70_RS06660	COG1063	alcohol dehydrogenase
KCX70_RS06680	COG1012	belongs to the aldehyde dehydrogenase family
KCX70_RS06695	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS06735	COG1053	succinate dehydrogenase
KCX70_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS06755	COG2365	Tyrosine phosphatase family
KCX70_RS06770	COG1309	transcriptional regulator
KCX70_RS06775	COG0583	DNA-binding transcription factor activity
KCX70_RS06795	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS06825	COG1024	Enoyl-CoA hydratase
KCX70_RS06830	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS06840	COG1309	transcriptional regulator
KCX70_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS06885	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KCX70_RS06905	COG4221	oxidoreductase activity
KCX70_RS06920	COG2223	nitrite transmembrane transporter activity
KCX70_RS06925	COG0840	transmembrane signaling receptor activity
KCX70_RS06945	COG0179	Fumarylacetoacetate (FAA) hydrolase
KCX70_RS06975	COG0179	Fumarylacetoacetate (FAA) hydrolase
KCX70_RS06985	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KCX70_RS06995	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS07015	COG0179	Fumarylacetoacetate (FAA) hydrolase
KCX70_RS07020	COG1250	3-hydroxyacyl-CoA dehydrogenase
KCX70_RS07025	COG0183	Belongs to the thiolase family
KCX70_RS07035	COG2124	cytochrome p450
KCX70_RS07045	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS07055	COG1024	Enoyl-CoA hydratase
KCX70_RS07060	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS07070	COG2267	carboxylic ester hydrolase activity
KCX70_RS07110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KCX70_RS07115	COG2235	arginine
KCX70_RS07120	COG1288	antiporter activity
KCX70_RS07125	COG0842	Transport permease protein
KCX70_RS07130	COG1129	ABC transporter
KCX70_RS07130	COG0842	Transport permease protein
KCX70_RS07135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KCX70_RS07175	COG5001	Diguanylate cyclase
KCX70_RS07215	COG0590	tRNA wobble adenosine to inosine editing
KCX70_RS07220	COG3842	ATPase activity
KCX70_RS07230	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KCX70_RS07250	COG1914	H( )-stimulated, divalent metal cation uptake system
KCX70_RS07255	COG1984	allophanate hydrolase subunit 2
KCX70_RS07260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KCX70_RS07265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KCX70_RS07275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KCX70_RS07280	COG0243	molybdopterin cofactor binding
KCX70_RS07285	COG1902	pentaerythritol trinitrate reductase activity
KCX70_RS07300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KCX70_RS07310	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KCX70_RS07320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KCX70_RS07350	COG0318	PFAM AMP-dependent synthetase and ligase
KCX70_RS07355	COG0235	Class ii aldolase
KCX70_RS07360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KCX70_RS07365	COG3179	chitinase
KCX70_RS07400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KCX70_RS07425	COG1801	Protein of unknown function DUF72
KCX70_RS07435	COG0742	ribosomal rna small subunit methyltransferase
KCX70_RS07455	COG0753	catalase activity
KCX70_RS07460	COG0483	inositol monophosphate 1-phosphatase activity
KCX70_RS07470	COG0668	transmembrane transport
KCX70_RS07490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KCX70_RS07500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KCX70_RS07510	COG1283	sodium-dependent phosphate transmembrane transporter activity
KCX70_RS07525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KCX70_RS07535	COG0069	glutamate synthase activity
KCX70_RS07545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KCX70_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS07570	COG2814	Major facilitator Superfamily
KCX70_RS07580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KCX70_RS07585	COG0840	transmembrane signaling receptor activity
KCX70_RS07595	COG0826	peptidase U32
KCX70_RS07600	COG4773	Receptor
KCX70_RS07620	COG4771	TonB-dependent receptor
KCX70_RS07675	COG0840	transmembrane signaling receptor activity
KCX70_RS07690	COG2188	Transcriptional regulator
KCX70_RS07710	COG0655	NAD(P)H dehydrogenase (quinone) activity
KCX70_RS07720	COG0789	Transcriptional regulator
KCX70_RS07740	COG1733	regulation of RNA biosynthetic process
KCX70_RS07745	COG0596	Alpha beta hydrolase
KCX70_RS07760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KCX70_RS07775	COG1126	abc transporter atp-binding protein
KCX70_RS07780	COG0765	amino acid transport
KCX70_RS07785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KCX70_RS07790	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KCX70_RS07815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KCX70_RS07830	COG1017	nitric oxide dioxygenase activity
KCX70_RS07830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KCX70_RS07835	COG0625	glutathione transferase activity
KCX70_RS07840	COG2226	methyltransferase
KCX70_RS07845	COG0840	transmembrane signaling receptor activity
KCX70_RS07860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KCX70_RS07865	COG0583	DNA-binding transcription factor activity
KCX70_RS07870	COG0697	spore germination
KCX70_RS07890	COG5001	Diguanylate cyclase
KCX70_RS07890	COG3300	MHYT domain
KCX70_RS07950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KCX70_RS07950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KCX70_RS07955	COG0745	RESPONSE REGULATOR receiver
KCX70_RS07960	COG2205	protein histidine kinase activity
KCX70_RS07965	COG2977	Belongs to the P-Pant transferase superfamily
KCX70_RS07975	COG2860	membrane
KCX70_RS07980	COG5002	protein histidine kinase activity
KCX70_RS07980	COG2205	protein histidine kinase activity
KCX70_RS07980	COG0784	Response regulator, receiver
KCX70_RS07985	COG0405	Gamma-glutamyltransferase
KCX70_RS07995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KCX70_RS08000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KCX70_RS08005	COG3956	TIGRFAM MazG family protein
KCX70_RS08040	COG1201	RNA secondary structure unwinding
KCX70_RS08045	COG1793	dna ligase
KCX70_RS08070	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
KCX70_RS08075	COG2943	transferase activity, transferring hexosyl groups
KCX70_RS08095	COG2132	Multicopper oxidase
KCX70_RS08125	COG1272	protein, Hemolysin III
KCX70_RS08145	COG2937	Belongs to the GPAT DAPAT family
KCX70_RS08160	COG1131	(ABC) transporter
KCX70_RS08175	COG1278	Cold shock
KCX70_RS08210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KCX70_RS08220	COG5001	Diguanylate cyclase
KCX70_RS08220	COG3300	MHYT domain
KCX70_RS08235	COG2130	NADP-dependent
KCX70_RS08240	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS08245	COG3135	benzoate transporter
KCX70_RS08250	COG1677	Flagellar hook-basal body complex protein FliE
KCX70_RS08285	COG0745	RESPONSE REGULATOR receiver
KCX70_RS08325	COG1987	bacterial-type flagellum assembly
KCX70_RS08340	COG2032	superoxide dismutase activity
KCX70_RS08345	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KCX70_RS08370	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
KCX70_RS08375	COG2198	Histidine kinase
KCX70_RS08375	COG0784	Response regulator, receiver
KCX70_RS08375	COG0643	Histidine kinase
KCX70_RS08385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KCX70_RS08390	COG1360	Flagellar Motor Protein
KCX70_RS08395	COG1192	Involved in chromosome partitioning
KCX70_RS08405	COG0835	chemotaxis
KCX70_RS08420	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KCX70_RS08450	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KCX70_RS08500	COG0500	methyltransferase
KCX70_RS08505	COG0501	Belongs to the peptidase M48B family
KCX70_RS08515	COG0436	Aminotransferase
KCX70_RS08520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KCX70_RS08525	COG0386	Belongs to the glutathione peroxidase family
KCX70_RS08535	COG0625	glutathione transferase activity
KCX70_RS08555	COG0640	Transcriptional regulator
KCX70_RS08575	COG0659	secondary active sulfate transmembrane transporter activity
KCX70_RS08590	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
KCX70_RS08605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KCX70_RS08610	COG0471	metal ion transport
KCX70_RS08615	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KCX70_RS08635	COG0776	regulation of translation
KCX70_RS08640	COG3206	protein involved in exopolysaccharide biosynthesis
KCX70_RS08640	COG0489	protein tyrosine kinase activity
KCX70_RS08640	COG3206	protein involved in exopolysaccharide biosynthesis
KCX70_RS08640	COG0489	protein tyrosine kinase activity
KCX70_RS08645	COG3206	protein involved in exopolysaccharide biosynthesis
KCX70_RS08645	COG0489	protein tyrosine kinase activity
KCX70_RS08655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KCX70_RS08695	COG1086	Polysaccharide biosynthesis protein
KCX70_RS08710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KCX70_RS08715	COG0110	maltose O-acetyltransferase activity
KCX70_RS08725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KCX70_RS08730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KCX70_RS08735	COG0583	DNA-binding transcription factor activity
KCX70_RS08750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KCX70_RS08755	COG0668	transmembrane transport
KCX70_RS08760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KCX70_RS08780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KCX70_RS08790	COG2988	succinylglutamate desuccinylase activity
KCX70_RS08800	COG1770	oligopeptidase
KCX70_RS08805	COG1250	3-hydroxyacyl-CoA dehydrogenase
KCX70_RS08805	COG1024	Enoyl-CoA hydratase
KCX70_RS08810	COG0183	Belongs to the thiolase family
KCX70_RS08845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KCX70_RS08875	COG0653	protein targeting
KCX70_RS08895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KCX70_RS08900	COG1012	belongs to the aldehyde dehydrogenase family
KCX70_RS08910	COG0387	Pfam Sodium calcium exchanger
KCX70_RS08920	COG1309	transcriptional regulator
KCX70_RS08925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KCX70_RS08935	COG3706	GGDEF domain
KCX70_RS08945	COG0745	RESPONSE REGULATOR receiver
KCX70_RS08970	COG0297	glycogen (starch) synthase activity
KCX70_RS08990	COG0297	glycogen (starch) synthase activity
KCX70_RS09055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KCX70_RS09060	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS09080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KCX70_RS09085	COG0066	3-isopropylmalate dehydratase activity
KCX70_RS09090	COG2226	methyltransferase
KCX70_RS09095	COG0473	3-isopropylmalate dehydrogenase activity
KCX70_RS09115	COG0135	phosphoribosylanthranilate isomerase activity
KCX70_RS09120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KCX70_RS09125	COG0285	dihydrofolate synthase activity
KCX70_RS09130	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KCX70_RS09135	COG1286	toxin biosynthetic process
KCX70_RS09165	COG1271	oxidase subunit
KCX70_RS09170	COG1294	oxidase, subunit
KCX70_RS09190	COG0446	pyridine nucleotide-disulphide oxidoreductase
KCX70_RS09190	COG1902	pentaerythritol trinitrate reductase activity
KCX70_RS09210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KCX70_RS09225	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KCX70_RS09230	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KCX70_RS09250	COG0308	aminopeptidase N
KCX70_RS09265	COG1007	ATP synthesis coupled electron transport
KCX70_RS09280	COG0713	ATP synthesis coupled electron transport
KCX70_RS09290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KCX70_RS09295	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KCX70_RS09320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KCX70_RS09325	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KCX70_RS09335	COG0243	molybdopterin cofactor binding
KCX70_RS09340	COG2146	nitrite reductase [NAD(P)H] activity
KCX70_RS09345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KCX70_RS09355	COG0515	serine threonine protein kinase
KCX70_RS09355	COG2815	serine threonine protein kinase
KCX70_RS09360	COG2223	nitrite transmembrane transporter activity
KCX70_RS09370	COG2197	response regulator
KCX70_RS09375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KCX70_RS09405	COG0714	Associated with various cellular activities
KCX70_RS09430	COG0167	dihydroorotate dehydrogenase activity
KCX70_RS09435	COG3130	regulation of translation
KCX70_RS09440	COG0116	Belongs to the methyltransferase superfamily
KCX70_RS09440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KCX70_RS09450	COG3171	Protein conserved in bacteria
KCX70_RS09505	COG0521	Mo-molybdopterin cofactor biosynthetic process
KCX70_RS09510	COG0303	'Molybdopterin
KCX70_RS09540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KCX70_RS09545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KCX70_RS09550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KCX70_RS09555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KCX70_RS09560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KCX70_RS09565	COG0072	phenylalanine-tRNA ligase activity
KCX70_RS09570	COG0776	regulation of translation
KCX70_RS09585	COG0587	DNA-directed DNA polymerase activity
KCX70_RS09600	COG3278	Belongs to the heme-copper respiratory oxidase family
KCX70_RS09610	COG0450	alkyl hydroperoxide reductase
KCX70_RS09615	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KCX70_RS09625	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KCX70_RS09630	COG1605	Chorismate mutase
KCX70_RS09630	COG0077	Prephenate dehydratase
KCX70_RS09635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KCX70_RS09640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KCX70_RS09645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KCX70_RS09660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KCX70_RS09665	COG0625	glutathione transferase activity
KCX70_RS09670	COG0302	gtp cyclohydrolase
KCX70_RS09675	COG2840	Smr protein MutS2
KCX70_RS09705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KCX70_RS09715	COG0235	Class ii aldolase
KCX70_RS09720	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KCX70_RS09725	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KCX70_RS09745	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KCX70_RS09760	COG0730	response to heat
KCX70_RS09770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KCX70_RS09775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KCX70_RS09780	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KCX70_RS09785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KCX70_RS09800	COG0573	inorganic phosphate transmembrane transporter activity
KCX70_RS09815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KCX70_RS09820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KCX70_RS09830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KCX70_RS09855	COG0348	domain, Protein
KCX70_RS09860	COG2010	Cytochrome c
KCX70_RS09875	COG3278	Belongs to the heme-copper respiratory oxidase family
KCX70_RS09880	COG2010	Cytochrome c
KCX70_RS09890	COG3278	Belongs to the heme-copper respiratory oxidase family
KCX70_RS09900	COG0840	transmembrane signaling receptor activity
KCX70_RS09910	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
KCX70_RS09925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KCX70_RS09930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KCX70_RS09930	COG2010	Cytochrome c
KCX70_RS09945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KCX70_RS09950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KCX70_RS09960	COG3115	cell septum assembly
KCX70_RS09965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KCX70_RS10010	COG2009	succinate dehydrogenase
KCX70_RS10015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KCX70_RS10020	COG1053	succinate dehydrogenase
KCX70_RS10025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KCX70_RS10045	COG0045	succinate-CoA ligase (ADP-forming) activity
KCX70_RS10095	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KCX70_RS10105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KCX70_RS10110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KCX70_RS10145	COG0628	permease
KCX70_RS10155	COG0709	Synthesizes selenophosphate from selenide and ATP
KCX70_RS10160	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
KCX70_RS10170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KCX70_RS10175	COG0714	Associated with various cellular activities
KCX70_RS10200	COG0084	hydrolase, TatD family'
KCX70_RS10205	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KCX70_RS10225	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KCX70_RS10230	COG4181	ATPase activity
KCX70_RS10245	COG1376	ErfK ybiS ycfS ynhG family protein
KCX70_RS10265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KCX70_RS10280	COG0560	Phosphoserine phosphatase
KCX70_RS10305	COG1802	Transcriptional regulator
KCX70_RS10315	COG0372	Belongs to the citrate synthase family
KCX70_RS10330	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KCX70_RS10340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KCX70_RS10355	COG0668	transmembrane transport
KCX70_RS10385	COG2153	protein acetylation
KCX70_RS10390	COG2850	peptidyl-arginine hydroxylation
KCX70_RS10400	COG2915	High frequency lysogenization protein hflD homolog
KCX70_RS10405	COG0482	sulfurtransferase activity
KCX70_RS10430	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KCX70_RS10435	COG0542	response to heat
KCX70_RS10440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KCX70_RS10445	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KCX70_RS10450	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KCX70_RS10455	COG0492	ferredoxin-NADP+ reductase activity
KCX70_RS10465	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KCX70_RS10470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KCX70_RS10475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KCX70_RS10480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KCX70_RS10485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KCX70_RS10485	COG1648	precorrin-2 dehydrogenase activity
KCX70_RS10490	COG0435	Glutathione S-transferase
KCX70_RS10495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KCX70_RS10500	COG2920	part of a sulfur-relay system
KCX70_RS10505	COG2168	tRNA wobble position uridine thiolation
KCX70_RS10530	COG4608	Belongs to the ABC transporter superfamily
KCX70_RS10535	COG0444	Belongs to the ABC transporter superfamily
KCX70_RS10540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KCX70_RS10545	COG0601	transmembrane transport
KCX70_RS10550	COG0747	negative chemotaxis
KCX70_RS10565	COG0697	spore germination
KCX70_RS10590	COG0437	4 iron, 4 sulfur cluster binding
KCX70_RS10635	COG1845	cytochrome c oxidase, subunit III
KCX70_RS10660	COG3383	formate dehydrogenase (NAD+) activity
KCX70_RS10680	COG4944	Protein of unknown function (DUF1109)
KCX70_RS10685	COG1595	DNA-templated transcription, initiation
KCX70_RS10695	COG3220	belongs to the UPF0276 family
KCX70_RS10710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KCX70_RS10740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KCX70_RS10750	COG3813	Protein conserved in bacteria
KCX70_RS10755	COG2205	protein histidine kinase activity
KCX70_RS10765	COG0784	Response regulator, receiver
KCX70_RS10765	COG4191	Histidine kinase
KCX70_RS10780	COG2388	GCN5-related N-acetyl-transferase
KCX70_RS10790	COG0348	domain, Protein
KCX70_RS10790	COG3901	Regulator of nitric oxide reductase transcription
KCX70_RS10795	COG0183	Belongs to the thiolase family
KCX70_RS10800	COG0784	Response regulator, receiver
KCX70_RS10800	COG0835	chemotaxis
KCX70_RS10810	COG0417	DNA replication proofreading
KCX70_RS10830	COG5642	Protein of unknown function (DUF2384)
KCX70_RS10850	COG2205	protein histidine kinase activity
KCX70_RS10860	COG2172	sigma factor antagonist activity
KCX70_RS10865	COG1366	Belongs to the anti-sigma-factor antagonist family
KCX70_RS10870	COG1366	Belongs to the anti-sigma-factor antagonist family
KCX70_RS10880	COG4991	sh3 domain protein
KCX70_RS10895	COG0515	serine threonine protein kinase
KCX70_RS10900	COG2116	formate transmembrane transporter activity
KCX70_RS10910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KCX70_RS10910	COG2146	nitrite reductase [NAD(P)H] activity
KCX70_RS10925	COG2130	NADP-dependent
KCX70_RS10990	COG0728	peptidoglycan biosynthetic process
KCX70_RS11045	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS11050	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KCX70_RS11065	COG0437	4 iron, 4 sulfur cluster binding
KCX70_RS11070	COG2864	formate dehydrogenase
KCX70_RS11090	COG0366	Alpha amylase catalytic
KCX70_RS11095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KCX70_RS11105	COG0392	lysyltransferase activity
KCX70_RS11110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KCX70_RS11115	COG3568	Endonuclease Exonuclease Phosphatase
KCX70_RS11130	COG0583	DNA-binding transcription factor activity
KCX70_RS11135	COG3384	dioxygenase
KCX70_RS11145	COG0739	heme binding
KCX70_RS11170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KCX70_RS11175	COG0297	glycogen (starch) synthase activity
KCX70_RS11180	COG1546	Belongs to the CinA family
KCX70_RS11180	COG1058	Belongs to the CinA family
KCX70_RS11185	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KCX70_RS11185	COG3264	Mechanosensitive ion channel
KCX70_RS11190	COG3685	Protein conserved in bacteria
KCX70_RS11215	COG0583	DNA-binding transcription factor activity
KCX70_RS11220	COG2194	sulfuric ester hydrolase activity
KCX70_RS11265	COG2149	membrane
KCX70_RS11320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KCX70_RS11325	COG0277	FAD linked oxidase domain protein
KCX70_RS11330	COG2721	sulfolactate sulfo-lyase activity
KCX70_RS11340	COG1012	belongs to the aldehyde dehydrogenase family
KCX70_RS11345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KCX70_RS11355	COG3181	Tripartite tricarboxylate transporter family receptor
KCX70_RS11390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KCX70_RS11400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KCX70_RS11465	COG0322	excinuclease ABC activity
KCX70_RS11475	COG0640	Transcriptional regulator
KCX70_RS11480	COG0431	NADPH-dependent FMN reductase
KCX70_RS11485	COG1742	UPF0060 membrane protein
KCX70_RS11490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KCX70_RS11500	COG0784	Response regulator, receiver
KCX70_RS11500	COG2205	protein histidine kinase activity
KCX70_RS11515	COG0535	radical SAM domain protein
KCX70_RS11525	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
KCX70_RS11530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KCX70_RS11570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KCX70_RS11575	COG0167	dihydroorotate dehydrogenase activity
KCX70_RS11620	COG2323	membrane
KCX70_RS11650	COG3851	Histidine kinase
KCX70_RS11675	COG1131	(ABC) transporter
KCX70_RS11690	COG2205	protein histidine kinase activity
KCX70_RS11690	COG0784	Response regulator, receiver
KCX70_RS11705	COG1025	Belongs to the peptidase M16 family
KCX70_RS11715	COG1366	Belongs to the anti-sigma-factor antagonist family
KCX70_RS11725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KCX70_RS11730	COG1090	epimerase
KCX70_RS11735	COG3272	Protein of unknown function (DUF1722)
KCX70_RS11740	COG0789	Transcriptional regulator
KCX70_RS11745	COG0415	Belongs to the DNA photolyase family
KCX70_RS11765	COG0583	DNA-binding transcription factor activity
KCX70_RS11770	COG0625	glutathione transferase activity
KCX70_RS11775	COG0210	DNA helicase
KCX70_RS11780	COG4294	response to UV
KCX70_RS11795	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KCX70_RS11830	COG4221	oxidoreductase activity
KCX70_RS11865	COG1024	Enoyl-CoA hydratase
KCX70_RS11870	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS11875	COG0318	PFAM AMP-dependent synthetase and ligase
KCX70_RS11880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KCX70_RS11885	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS11910	COG1024	Enoyl-CoA hydratase
KCX70_RS11950	COG0318	PFAM AMP-dependent synthetase and ligase
KCX70_RS11955	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS11960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KCX70_RS11965	COG1024	Enoyl-CoA hydratase
KCX70_RS11970	COG4770	biotin carboxylase activity
KCX70_RS11995	COG0789	Transcriptional regulator
KCX70_RS12005	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KCX70_RS12015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KCX70_RS12025	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS12050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KCX70_RS12055	COG0251	oxidation-reduction process
KCX70_RS12075	COG0583	DNA-binding transcription factor activity
KCX70_RS12100	COG0583	DNA-binding transcription factor activity
KCX70_RS12105	COG2249	NAD(P)H dehydrogenase (quinone) activity
KCX70_RS12115	COG0025	NhaP-type Na H and K H
KCX70_RS12120	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KCX70_RS12130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KCX70_RS12140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KCX70_RS12145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KCX70_RS12150	COG1414	Transcriptional regulator
KCX70_RS12155	COG0784	Response regulator, receiver
KCX70_RS12155	COG4191	Histidine kinase
KCX70_RS12160	COG0583	DNA-binding transcription factor activity
KCX70_RS12165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KCX70_RS12180	COG2031	fatty acid transporter
KCX70_RS12185	COG1696	Membrane protein involved in D-alanine export
KCX70_RS12230	COG3284	Transcriptional regulator
KCX70_RS12245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KCX70_RS12250	COG1063	alcohol dehydrogenase
KCX70_RS12255	COG0022	dehydrogenase e1 component
KCX70_RS12260	COG0508	dehydrogenase complex catalyzes the overall conversion of
KCX70_RS12265	COG0508	dehydrogenase complex catalyzes the overall conversion of
KCX70_RS12270	COG0095	Lipoate-protein ligase
KCX70_RS12295	COG3257	ureidoglycine aminohydrolase activity
KCX70_RS12305	COG0625	glutathione transferase activity
KCX70_RS12310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KCX70_RS12320	COG1309	transcriptional regulator
KCX70_RS12325	COG2010	Cytochrome c
KCX70_RS12330	COG0753	catalase activity
KCX70_RS12335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KCX70_RS12365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KCX70_RS12380	COG0395	ABC-type sugar transport system, permease component
KCX70_RS12390	COG3842	ATPase activity
KCX70_RS12400	COG3284	Transcriptional regulator
KCX70_RS12405	COG0215	cysteine-tRNA ligase activity
KCX70_RS12410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KCX70_RS12415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KCX70_RS12420	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KCX70_RS12445	COG2814	Major facilitator Superfamily
KCX70_RS12450	COG0583	DNA-binding transcription factor activity
KCX70_RS12455	COG0488	(ABC) transporter
KCX70_RS12465	COG2267	carboxylic ester hydrolase activity
KCX70_RS12470	COG1968	undecaprenyl-diphosphatase activity
KCX70_RS12475	COG0840	transmembrane signaling receptor activity
KCX70_RS12495	COG2323	membrane
KCX70_RS12510	COG3706	GGDEF domain
KCX70_RS12515	COG2197	response regulator
KCX70_RS12520	COG0316	Belongs to the HesB IscA family
KCX70_RS12520	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KCX70_RS12545	COG1846	Transcriptional regulator
KCX70_RS12555	COG2223	nitrite transmembrane transporter activity
KCX70_RS12560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KCX70_RS12605	COG0604	alcohol dehydrogenase
KCX70_RS12610	COG0616	signal peptide processing
KCX70_RS12630	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS12645	COG2816	NAD+ diphosphatase activity
KCX70_RS12655	COG1024	Enoyl-CoA hydratase
KCX70_RS12665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KCX70_RS12670	COG4974	Belongs to the 'phage' integrase family
KCX70_RS12710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KCX70_RS12740	COG0483	inositol monophosphate 1-phosphatase activity
KCX70_RS12750	COG0328	RNA-DNA hybrid ribonuclease activity
KCX70_RS12765	COG0741	lytic transglycosylase activity
KCX70_RS12765	COG1388	LysM domain
KCX70_RS12775	COG4166	transmembrane transport
KCX70_RS12785	COG4174	ABC transporter (Permease)
KCX70_RS12790	COG4239	(ABC) transporter, permease
KCX70_RS12795	COG4172	Belongs to the ABC transporter superfamily
KCX70_RS12805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KCX70_RS12815	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KCX70_RS12820	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KCX70_RS12825	COG0740	serine-type endopeptidase activity
KCX70_RS12830	COG0544	peptidyl-prolyl cis-trans isomerase activity
KCX70_RS12835	COG2259	Doxx family
KCX70_RS12850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KCX70_RS12860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KCX70_RS12875	COG1115	amino acid carrier protein
KCX70_RS12880	COG2911	Protein conserved in bacteria
KCX70_RS12885	COG0729	surface antigen
KCX70_RS12920	COG1175	transmembrane transport
KCX70_RS12940	COG1070	Carbohydrate kinase
KCX70_RS12955	COG1609	Transcriptional regulator
KCX70_RS12960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KCX70_RS12965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KCX70_RS12970	COG3265	gluconokinase activity
KCX70_RS12975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KCX70_RS12980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KCX70_RS13000	COG2358	TRAP transporter, solute receptor (TAXI family
KCX70_RS13010	COG0628	permease
KCX70_RS13015	COG2056	Na+-H+ antiporter family
KCX70_RS13020	COG0720	synthase
KCX70_RS13050	COG0402	S-adenosylhomocysteine deaminase activity
KCX70_RS13055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KCX70_RS13060	COG0546	phosphoglycolate phosphatase activity
KCX70_RS13065	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS13080	COG0800	Aldolase
KCX70_RS13095	COG1737	Transcriptional regulator
KCX70_RS13105	COG4580	involved in the transport of maltose and maltodextrins
KCX70_RS13110	COG3842	ATPase activity
KCX70_RS13120	COG1175	transmembrane transport
KCX70_RS13125	COG1653	transport
KCX70_RS13165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KCX70_RS13170	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KCX70_RS13175	COG0180	Tryptophanyl-tRNA synthetase
KCX70_RS13180	COG0009	L-threonylcarbamoyladenylate synthase
KCX70_RS13185	COG0613	PHP domain protein
KCX70_RS13190	COG2917	probably involved in intracellular septation
KCX70_RS13195	COG2350	Protein conserved in bacteria
KCX70_RS13205	COG0745	RESPONSE REGULATOR receiver
KCX70_RS13220	COG0778	Nitroreductase
KCX70_RS13225	COG0727	PFAM Uncharacterised protein family (UPF0153)
KCX70_RS13230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KCX70_RS13235	COG0590	tRNA wobble adenosine to inosine editing
KCX70_RS13240	COG2354	Protein conserved in bacteria
KCX70_RS13255	COG2207	Transcriptional regulator
KCX70_RS13280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KCX70_RS13290	COG1012	belongs to the aldehyde dehydrogenase family
KCX70_RS13310	COG1752	Esterase of the alpha-beta hydrolase superfamily
KCX70_RS13320	COG1846	Transcriptional regulator
KCX70_RS13325	COG0514	ATP-dependent DNA helicase (RecQ)
KCX70_RS13335	COG2832	Protein of unknown function (DUF454)
KCX70_RS13350	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
KCX70_RS13365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KCX70_RS13395	COG0121	glutamine amidotransferase
KCX70_RS13405	COG0589	response to stress
KCX70_RS13415	COG0488	(ABC) transporter
KCX70_RS13425	COG3217	Mosc domain protein beta barrel domain protein
KCX70_RS13425	COG0633	Ferredoxin
KCX70_RS13440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KCX70_RS13445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KCX70_RS13475	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KCX70_RS13515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KCX70_RS13525	COG0745	RESPONSE REGULATOR receiver
KCX70_RS13535	COG2853	Lipoprotein
KCX70_RS13545	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KCX70_RS13545	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KCX70_RS13550	COG0842	Transport permease protein
KCX70_RS13555	COG1131	(ABC) transporter
KCX70_RS13560	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS13595	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS13600	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
KCX70_RS13625	COG1113	amino acid transport
KCX70_RS13630	COG0840	transmembrane signaling receptor activity
KCX70_RS13635	COG1132	(ABC) transporter
KCX70_RS13645	COG1054	Belongs to the UPF0176 family
KCX70_RS13650	COG0271	Belongs to the BolA IbaG family
KCX70_RS13660	COG0114	fumarate hydratase activity
KCX70_RS13665	COG0183	Belongs to the thiolase family
KCX70_RS13675	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KCX70_RS13675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KCX70_RS13685	COG0583	DNA-binding transcription factor activity
KCX70_RS13695	COG0367	asparagine synthase
KCX70_RS13700	COG0189	ligase activity
KCX70_RS13700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KCX70_RS13705	COG1363	Peptidase, m42
KCX70_RS13715	COG3089	Belongs to the UPF0270 family
KCX70_RS13735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KCX70_RS13740	COG3162	membrane
KCX70_RS13755	COG2853	Lipoprotein
KCX70_RS13765	COG1560	Kdo2-lipid A biosynthetic process
KCX70_RS13770	COG0850	regulation of cytokinetic process
KCX70_RS13775	COG2894	cell division
KCX70_RS13780	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KCX70_RS13785	COG0564	pseudouridine synthase activity
KCX70_RS13790	COG1362	aminopeptidase activity
KCX70_RS13795	COG0793	Belongs to the peptidase S41A family
KCX70_RS13800	COG2200	EAL domain
KCX70_RS13825	COG1555	photosystem II stabilization
KCX70_RS13835	COG1256	bacterial-type flagellum assembly
KCX70_RS13845	COG1706	bacterial-type flagellum-dependent cell motility
KCX70_RS13850	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KCX70_RS13860	COG4787	bacterial-type flagellum-dependent cell motility
KCX70_RS13865	COG1749	Flagellar hook protein flgE
KCX70_RS13880	COG1815	bacterial-type flagellum-dependent cell motility
KCX70_RS13885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KCX70_RS13890	COG0784	Response regulator, receiver
KCX70_RS13890	COG0835	chemotaxis
KCX70_RS13910	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
KCX70_RS13915	COG0582	viral genome integration into host DNA
KCX70_RS14025	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KCX70_RS14040	COG2239	Acts as a magnesium transporter
KCX70_RS14065	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KCX70_RS14070	COG0527	aspartate kinase activity
KCX70_RS14075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KCX70_RS14090	COG2983	Belongs to the UPF0260 family
KCX70_RS14095	COG3100	YcgL domain-containing protein
KCX70_RS14110	COG2067	long-chain fatty acid transport protein
KCX70_RS14140	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KCX70_RS14145	COG0406	alpha-ribazole phosphatase activity
KCX70_RS14160	COG1492	cobalamin metabolic process
KCX70_RS14170	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KCX70_RS14175	COG0778	Nitroreductase
KCX70_RS14180	COG1797	cobyrinic acid a,c-diamide synthase activity
KCX70_RS14195	COG4206	TonB-dependent receptor
KCX70_RS14205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KCX70_RS14215	COG0791	NLP P60 protein
KCX70_RS14220	COG0791	NLP P60 protein
KCX70_RS14230	COG2818	Glycosylase
KCX70_RS14235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KCX70_RS14240	COG0037	tRNA processing
KCX70_RS14260	COG3091	SprT-like family
KCX70_RS14265	COG2814	Major facilitator Superfamily
KCX70_RS14270	COG4459	periplasmic nitrate reductase
KCX70_RS14280	COG0243	molybdopterin cofactor binding
KCX70_RS14290	COG3005	denitrification pathway
KCX70_RS14335	COG2165	general secretion pathway protein
KCX70_RS14345	COG2165	general secretion pathway protein
KCX70_RS14350	COG1459	type II secretion system
KCX70_RS14355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KCX70_RS14365	COG3267	Type II secretory pathway component ExeA
KCX70_RS14365	COG3409	Peptidoglycan-binding domain 1 protein
KCX70_RS14395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KCX70_RS14430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KCX70_RS14435	COG0583	DNA-binding transcription factor activity
KCX70_RS14450	COG0556	nucleotide-excision repair
KCX70_RS14475	COG0545	Peptidyl-prolyl cis-trans isomerase
KCX70_RS14490	COG2974	May be involved in recombination
KCX70_RS14495	COG0385	Bile acid
KCX70_RS14500	COG2076	Multidrug Resistance protein
KCX70_RS14510	COG0366	Alpha amylase catalytic
KCX70_RS14530	COG3833	ABC-type maltose transport systems, permease component
KCX70_RS14535	COG1175	transmembrane transport
KCX70_RS14545	COG0366	Alpha amylase catalytic
KCX70_RS14565	COG4580	involved in the transport of maltose and maltodextrins
KCX70_RS14575	COG2182	Extracellular solute-binding protein
KCX70_RS14580	COG2814	Major facilitator Superfamily
KCX70_RS14600	COG2205	protein histidine kinase activity
KCX70_RS14605	COG3174	membrane
KCX70_RS14685	COG3706	GGDEF domain
KCX70_RS14705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KCX70_RS14740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KCX70_RS14750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KCX70_RS14760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KCX70_RS14770	COG0425	Belongs to the sulfur carrier protein TusA family
KCX70_RS14775	COG4783	chaperone-mediated protein folding
KCX70_RS14780	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KCX70_RS14785	COG0427	acetyl-CoA hydrolase
KCX70_RS14795	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KCX70_RS14800	COG0602	queuosine metabolic process
KCX70_RS14805	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
KCX70_RS14810	COG2885	chlorophyll binding
KCX70_RS14815	COG0823	Involved in the tonB-independent uptake of proteins
KCX70_RS14835	COG0824	Thioesterase
KCX70_RS14840	COG2255	four-way junction helicase activity
KCX70_RS14845	COG0632	four-way junction helicase activity
KCX70_RS14850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KCX70_RS14860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KCX70_RS14865	COG0783	Belongs to the Dps family
KCX70_RS14875	COG2900	Belongs to the SlyX family
KCX70_RS14890	COG0442	prolyl-tRNA aminoacylation
KCX70_RS14910	COG1295	ribonuclease BN
KCX70_RS14915	COG1393	Belongs to the ArsC family
KCX70_RS14935	COG0628	permease
KCX70_RS14945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KCX70_RS14950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KCX70_RS14965	COG0436	Aminotransferase
KCX70_RS14985	COG1393	Belongs to the ArsC family
KCX70_RS14990	COG2171	N-acyltransferase activity
KCX70_RS14995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KCX70_RS15005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KCX70_RS15010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KCX70_RS15015	COG2226	methyltransferase
KCX70_RS15045	COG1113	amino acid transport
KCX70_RS15050	COG0084	hydrolase, TatD family'
KCX70_RS15065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KCX70_RS15070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KCX70_RS15080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KCX70_RS15085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KCX70_RS15100	COG0416	fatty acid biosynthetic process
KCX70_RS15105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KCX70_RS15110	COG1399	metal-binding, possibly nucleic acid-binding protein
KCX70_RS15115	COG0424	maF-like protein
KCX70_RS15120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KCX70_RS15120	COG0616	signal peptide processing
KCX70_RS15135	COG1530	ribonuclease E activity
KCX70_RS15140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KCX70_RS15145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KCX70_RS15150	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KCX70_RS15155	COG2835	tetraacyldisaccharide 4'-kinase activity
KCX70_RS15160	COG1663	tetraacyldisaccharide 4'-kinase activity
KCX70_RS15175	COG2333	competence protein COMEC
KCX70_RS15175	COG0658	competence protein
KCX70_RS15185	COG4591	ABC-type transport system involved in lipoprotein release permease component
KCX70_RS15190	COG1136	(ABC) transporter
KCX70_RS15195	COG4591	ABC-type transport system involved in lipoprotein release permease component
KCX70_RS15210	COG0584	glycerophosphoryl diester phosphodiesterase
KCX70_RS15215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KCX70_RS15225	COG1477	protein flavinylation
KCX70_RS15235	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KCX70_RS15250	COG1805	sodium ion transport
KCX70_RS15265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KCX70_RS15270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KCX70_RS15280	COG0655	NAD(P)H dehydrogenase (quinone) activity
KCX70_RS15290	COG0596	Alpha beta hydrolase
KCX70_RS15295	COG1346	cytolysis
KCX70_RS15300	COG1380	Effector of murein hydrolase LrgA
KCX70_RS15305	COG0348	domain, Protein
KCX70_RS15310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KCX70_RS15315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KCX70_RS15315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KCX70_RS15340	COG0625	glutathione transferase activity
KCX70_RS15345	COG1309	transcriptional regulator
KCX70_RS15350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KCX70_RS15355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KCX70_RS15365	COG0004	ammonium transporteR
KCX70_RS15380	COG2258	MOSC domain
KCX70_RS15385	COG0697	spore germination
KCX70_RS15390	COG0217	transcriptional regulatory protein
KCX70_RS15410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KCX70_RS15455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KCX70_RS15460	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KCX70_RS15465	COG0585	pseudouridine synthase activity
KCX70_RS15470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KCX70_RS15475	COG0640	Transcriptional regulator
KCX70_RS15480	COG1902	pentaerythritol trinitrate reductase activity
KCX70_RS15490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KCX70_RS15495	COG0583	DNA-binding transcription factor activity
KCX70_RS15510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KCX70_RS15520	COG0148	phosphopyruvate hydratase activity
KCX70_RS15525	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KCX70_RS15530	COG0504	CTP synthase activity
KCX70_RS15535	COG0037	tRNA processing
KCX70_RS15540	COG0825	malonyl-CoA metabolic process
KCX70_RS15550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KCX70_RS15555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KCX70_RS15560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KCX70_RS15565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KCX70_RS15590	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KCX70_RS15600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KCX70_RS15605	COG0233	cytoplasmic translational termination
KCX70_RS15610	COG0528	UMP kinase activity
KCX70_RS15615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KCX70_RS15620	COG0052	Belongs to the universal ribosomal protein uS2 family
KCX70_RS15625	COG0024	Methionine aminopeptidase
KCX70_RS15630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KCX70_RS15635	COG1320	monovalent cation:proton antiporter activity
KCX70_RS15640	COG2212	antiporter activity
KCX70_RS15645	COG1863	multisubunit Na H antiporter MnhE subunit
KCX70_RS15650	COG0651	ATP synthesis coupled electron transport
KCX70_RS15655	COG1006	Multisubunit Na H antiporter MnhC subunit
KCX70_RS15660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KCX70_RS15660	COG2111	Na H antiporter
KCX70_RS15675	COG0259	pyridoxamine-phosphate oxidase activity
KCX70_RS15685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KCX70_RS15690	COG1199	ATP-dependent helicase activity
KCX70_RS15710	COG3012	SEC-C Motif Domain Protein
KCX70_RS15720	COG0583	DNA-binding transcription factor activity
KCX70_RS15730	COG0697	spore germination
KCX70_RS15735	COG3148	PFAM DTW domain containing protein
KCX70_RS15750	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KCX70_RS15760	COG2137	regulation of response to DNA damage stimulus
KCX70_RS15765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KCX70_RS15770	COG1546	Belongs to the CinA family
KCX70_RS15815	COG0582	viral genome integration into host DNA
KCX70_RS15820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KCX70_RS15825	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KCX70_RS15850	COG1295	ribonuclease BN
KCX70_RS15880	COG2184	nucleotidyltransferase activity
KCX70_RS15905	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KCX70_RS15925	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KCX70_RS15950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KCX70_RS15975	COG0489	protein tyrosine kinase activity
KCX70_RS15995	COG2996	Protein conserved in bacteria
KCX70_RS16000	COG4993	Dehydrogenase
KCX70_RS16005	COG2133	pyrroloquinoline quinone binding
KCX70_RS16040	COG0656	L-ascorbic acid biosynthetic process
KCX70_RS16050	COG1280	lysine exporter protein (LysE YggA)
KCX70_RS16070	COG1462	curli production assembly transport component CsgG
KCX70_RS16090	COG0116	Belongs to the methyltransferase superfamily
KCX70_RS16090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KCX70_RS16095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KCX70_RS16100	COG4772	TonB-dependent receptor
KCX70_RS16110	COG1012	belongs to the aldehyde dehydrogenase family
KCX70_RS16115	COG3284	Transcriptional regulator
KCX70_RS16130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KCX70_RS16160	COG1280	lysine exporter protein (LysE YggA)
KCX70_RS16165	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KCX70_RS16165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KCX70_RS16180	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KCX70_RS16195	COG2207	Transcriptional regulator
KCX70_RS16210	COG1120	ATPase activity
KCX70_RS16215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KCX70_RS16220	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KCX70_RS16225	COG4773	Receptor
KCX70_RS16250	COG3486	L-lysine 6-monooxygenase (NADPH) activity
KCX70_RS16280	COG3287	FIST C domain
KCX70_RS16280	COG2199	diguanylate cyclase activity
KCX70_RS16280	COG2200	EAL domain
KCX70_RS16285	COG0708	Exodeoxyribonuclease III
KCX70_RS16295	COG3960	tartronate-semialdehyde synthase activity
KCX70_RS16300	COG3622	Belongs to the hyi family
KCX70_RS16305	COG2084	Dehydrogenase
KCX70_RS16315	COG0469	pyruvate kinase activity
KCX70_RS16330	COG1017	nitric oxide dioxygenase activity
KCX70_RS16330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KCX70_RS16350	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KCX70_RS16375	COG0583	DNA-binding transcription factor activity
KCX70_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS16395	COG0717	Belongs to the dCTP deaminase family
KCX70_RS16400	COG1278	Cold shock
KCX70_RS16405	COG0489	protein tyrosine kinase activity
KCX70_RS16410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KCX70_RS16410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KCX70_RS16445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KCX70_RS16475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KCX70_RS16490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KCX70_RS16500	COG2226	methyltransferase
KCX70_RS16505	COG0500	methyltransferase
KCX70_RS16515	COG0583	DNA-binding transcription factor activity
KCX70_RS16525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KCX70_RS16530	COG1381	Involved in DNA repair and RecF pathway recombination
KCX70_RS16540	COG0571	ribonuclease III activity
KCX70_RS16555	COG0481	GTPase activity
KCX70_RS16560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KCX70_RS16595	COG0354	folic acid binding
KCX70_RS16610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KCX70_RS16620	COG1024	Enoyl-CoA hydratase
KCX70_RS16630	COG4657	Part of a membrane complex involved in electron transport
KCX70_RS16635	COG2878	Part of a membrane complex involved in electron transport
KCX70_RS16645	COG4658	electron transport chain
KCX70_RS16650	COG4659	FMN binding
KCX70_RS16660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KCX70_RS16670	COG0346	lactoylglutathione lyase activity
KCX70_RS16675	COG0137	argininosuccinate synthase activity
KCX70_RS16690	COG3188	usher protein
KCX70_RS16695	COG3121	Chaperone
KCX70_RS16705	COG0418	dihydroorotase activity
KCX70_RS16725	COG3791	Glutathione-dependent formaldehyde-activating
KCX70_RS16735	COG4974	Belongs to the 'phage' integrase family
KCX70_RS16740	COG0335	large ribosomal subunit rRNA binding
KCX70_RS16745	COG0336	Belongs to the RNA methyltransferase TrmD family
KCX70_RS16750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KCX70_RS16755	COG0228	four-way junction DNA binding
KCX70_RS16760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KCX70_RS16765	COG4137	Cytochrome C assembly protein
KCX70_RS16770	COG4536	flavin adenine dinucleotide binding
KCX70_RS16775	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KCX70_RS16800	COG3034	peptidoglycan biosynthetic process
KCX70_RS16805	COG1846	Transcriptional regulator
KCX70_RS16810	COG1764	response to oxidative stress
KCX70_RS16820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KCX70_RS16820	COG0047	phosphoribosylformylglycinamidine synthase activity
KCX70_RS16825	COG1126	abc transporter atp-binding protein
KCX70_RS16830	COG0765	amino acid transport
KCX70_RS16835	COG4597	amino acid ABC transporter
KCX70_RS16840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KCX70_RS16850	COG3706	GGDEF domain
KCX70_RS16865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KCX70_RS16870	COG0315	cyclic pyranopterin monophosphate synthase activity
KCX70_RS16875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KCX70_RS16885	COG3022	response to hydroperoxide
KCX70_RS16900	COG0433	COG0433 Predicted ATPase
KCX70_RS16910	COG0788	formyltetrahydrofolate deformylase activity
KCX70_RS16920	COG2925	Exonuclease
KCX70_RS16945	COG0714	Associated with various cellular activities
KCX70_RS16990	COG0840	transmembrane signaling receptor activity
KCX70_RS16995	COG4628	conserved protein (DUF2132)
KCX70_RS17000	COG0693	protein deglycase activity
KCX70_RS17045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KCX70_RS17065	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
KCX70_RS17080	COG1309	transcriptional regulator
KCX70_RS17085	COG0386	Belongs to the glutathione peroxidase family
KCX70_RS17095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KCX70_RS17105	COG0204	Acyl-transferase
KCX70_RS17115	COG5002	protein histidine kinase activity
KCX70_RS17115	COG0784	Response regulator, receiver
KCX70_RS17115	COG2205	protein histidine kinase activity
KCX70_RS17120	COG2885	chlorophyll binding
KCX70_RS17125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KCX70_RS17130	COG4191	Histidine kinase
KCX70_RS17130	COG0784	Response regulator, receiver
KCX70_RS17135	COG0318	PFAM AMP-dependent synthetase and ligase
KCX70_RS17140	COG1280	lysine exporter protein (LysE YggA)
KCX70_RS17145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KCX70_RS17150	COG2813	Specifically methylates the guanine in position
KCX70_RS17155	COG2119	membrane
KCX70_RS17165	COG0501	Belongs to the peptidase M48B family
KCX70_RS17220	COG0659	secondary active sulfate transmembrane transporter activity
KCX70_RS17225	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS17230	COG2201	protein-glutamate methylesterase activity
KCX70_RS17235	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KCX70_RS17240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KCX70_RS17245	COG0835	chemotaxis
KCX70_RS17250	COG0840	transmembrane signaling receptor activity
KCX70_RS17255	COG0643	Histidine kinase
KCX70_RS17255	COG2198	Histidine kinase
KCX70_RS17265	COG0745	RESPONSE REGULATOR receiver
KCX70_RS17270	COG0840	transmembrane signaling receptor activity
KCX70_RS17275	COG3851	Histidine kinase
KCX70_RS17280	COG2197	response regulator
KCX70_RS17300	COG1285	pathogenesis
KCX70_RS17315	COG0436	Aminotransferase
KCX70_RS17320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KCX70_RS17325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KCX70_RS17335	COG4191	Histidine kinase
KCX70_RS17355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KCX70_RS17360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KCX70_RS17365	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KCX70_RS17370	COG0166	Belongs to the GPI family
KCX70_RS17410	COG1185	polyribonucleotide nucleotidyltransferase activity
KCX70_RS17415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KCX70_RS17420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KCX70_RS17425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KCX70_RS17430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KCX70_RS17435	COG0195	Participates in both transcription termination and antitermination
KCX70_RS17440	COG0779	Required for maturation of 30S ribosomal subunits
KCX70_RS17455	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KCX70_RS17460	COG0149	triose-phosphate isomerase activity
KCX70_RS17465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KCX70_RS17470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KCX70_RS17480	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KCX70_RS17505	COG0505	Belongs to the CarA family
KCX70_RS17510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KCX70_RS17515	COG0484	heat shock protein binding
KCX70_RS17520	COG0443	Heat shock 70 kDa protein
KCX70_RS17525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KCX70_RS17530	COG0497	DNA recombination
KCX70_RS17545	COG2914	Belongs to the UPF0125 (RnfH) family
KCX70_RS17555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KCX70_RS17565	COG1620	l-lactate permease
KCX70_RS17615	COG3039	Transposase
KCX70_RS17620	COG0604	alcohol dehydrogenase
KCX70_RS17620	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS17620	COG3321	synthase
KCX70_RS17625	COG0583	DNA-binding transcription factor activity
KCX70_RS17650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KCX70_RS17665	COG0583	DNA-binding transcription factor activity
KCX70_RS17685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KCX70_RS17685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KCX70_RS17750	COG3039	Transposase
KCX70_RS17770	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
KCX70_RS17775	COG4974	Belongs to the 'phage' integrase family
KCX70_RS17785	COG1309	transcriptional regulator
KCX70_RS17790	COG0604	alcohol dehydrogenase
KCX70_RS17815	COG0583	DNA-binding transcription factor activity
KCX70_RS17820	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KCX70_RS17835	COG4221	oxidoreductase activity
KCX70_RS17840	COG0583	DNA-binding transcription factor activity
KCX70_RS17850	COG1902	pentaerythritol trinitrate reductase activity
KCX70_RS17855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KCX70_RS17885	COG3384	dioxygenase
KCX70_RS17890	COG0583	DNA-binding transcription factor activity
KCX70_RS17895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KCX70_RS17900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KCX70_RS17905	COG2828	Protein conserved in bacteria
KCX70_RS17915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KCX70_RS17920	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KCX70_RS17940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KCX70_RS17945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KCX70_RS17950	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KCX70_RS17955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KCX70_RS17960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KCX70_RS17965	COG1309	transcriptional regulator
KCX70_RS17975	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KCX70_RS17985	COG0679	Auxin Efflux Carrier
KCX70_RS17990	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KCX70_RS17995	COG3485	protocatechuate 3,4-dioxygenase
KCX70_RS18000	COG3485	protocatechuate 3,4-dioxygenase
KCX70_RS18005	COG0583	DNA-binding transcription factor activity
KCX70_RS18015	COG2375	cellular response to nickel ion
KCX70_RS18050	COG0583	DNA-binding transcription factor activity
KCX70_RS18055	COG0247	lactate metabolic process
KCX70_RS18055	COG0277	FAD linked oxidase domain protein
KCX70_RS18060	COG0154	amidase activity
KCX70_RS18070	COG1253	flavin adenine dinucleotide binding
KCX70_RS18080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KCX70_RS18125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KCX70_RS18140	COG2814	Major facilitator Superfamily
KCX70_RS18145	COG1309	transcriptional regulator
KCX70_RS18150	COG2608	mercury ion transmembrane transporter activity
KCX70_RS18155	COG2217	Heavy metal translocating P-type atpase
KCX70_RS18165	COG0840	transmembrane signaling receptor activity
KCX70_RS18175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KCX70_RS18185	COG1538	Outer membrane efflux protein
KCX70_RS18195	COG2169	Transcriptional regulator
KCX70_RS18195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KCX70_RS18205	COG0084	hydrolase, TatD family'
KCX70_RS18225	COG1515	deoxyribonuclease V activity
KCX70_RS18230	COG4977	sequence-specific DNA binding
KCX70_RS18235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KCX70_RS18270	COG1252	NADH dehydrogenase
KCX70_RS18350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KCX70_RS18360	COG2378	regulation of single-species biofilm formation
KCX70_RS18365	COG0305	Participates in initiation and elongation during chromosome replication
KCX70_RS18370	COG0359	binds to the 23S rRNA
KCX70_RS18380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KCX70_RS18385	COG0360	Binds together with S18 to 16S ribosomal RNA
KCX70_RS18395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KCX70_RS18400	COG0557	exoribonuclease II activity
KCX70_RS18415	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KCX70_RS18420	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KCX70_RS18425	COG0330	HflC and HflK could
KCX70_RS18430	COG0330	HflC and HflK could
KCX70_RS18435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KCX70_RS18440	COG1923	regulation of RNA biosynthetic process
KCX70_RS18445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KCX70_RS18450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KCX70_RS18455	COG0860	N-Acetylmuramoyl-L-alanine amidase
KCX70_RS18460	COG0802	atpase or kinase
KCX70_RS18465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KCX70_RS18465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KCX70_RS18480	COG4948	Mandelate Racemase Muconate Lactonizing
KCX70_RS18485	COG0800	Aldolase
KCX70_RS18490	COG3734	2-keto-3-deoxy-galactonokinase
KCX70_RS18495	COG1172	Belongs to the binding-protein-dependent transport system permease family
KCX70_RS18500	COG1129	ABC transporter
KCX70_RS18505	COG1879	ABC-type sugar transport system periplasmic component
KCX70_RS18510	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS18520	COG2186	Transcriptional regulator
KCX70_RS18540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KCX70_RS18550	COG0531	amino acid
KCX70_RS18555	COG4303	Ethanolamine ammonia lyase large subunit
KCX70_RS18560	COG4302	ethanolamine ammonia-lyase activity
KCX70_RS18580	COG3546	catalase activity
KCX70_RS18600	COG1230	cation diffusion facilitator family transporter
KCX70_RS18610	COG0730	response to heat
KCX70_RS18615	COG1722	exodeoxyribonuclease VII activity
KCX70_RS18620	COG0142	geranyltranstransferase activity
KCX70_RS18625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KCX70_RS18630	COG4206	TonB-dependent receptor
KCX70_RS18635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KCX70_RS18645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KCX70_RS18650	COG3577	Aspartyl protease
KCX70_RS18655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KCX70_RS18660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KCX70_RS18665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KCX70_RS18670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KCX70_RS18690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KCX70_RS18690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KCX70_RS18705	COG2264	protein methyltransferase activity
KCX70_RS18715	COG0425	Belongs to the sulfur carrier protein TusA family
KCX70_RS18720	COG2391	methyltransferase activity
KCX70_RS18725	COG3118	belongs to the thioredoxin family
KCX70_RS18735	COG1946	Acyl-CoA thioesterase
KCX70_RS18745	COG0123	including yeast histone deacetylase and acetoin utilization protein
KCX70_RS18765	COG0513	Belongs to the DEAD box helicase family
KCX70_RS18785	COG1028	Short-chain dehydrogenase reductase Sdr
KCX70_RS18825	COG2132	Multicopper oxidase
KCX70_RS18850	COG4221	oxidoreductase activity
KCX70_RS18890	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KCX70_RS18935	COG1061	Type III restriction enzyme res subunit
KCX70_RS18970	COG1643	Atp-dependent helicase
KCX70_RS18985	COG1522	sequence-specific DNA binding
KCX70_RS19015	COG0411	ABC transporter
KCX70_RS19035	COG0410	ABC transporter
KCX70_RS19050	COG0559	Belongs to the binding-protein-dependent transport system permease family
KCX70_RS19055	COG0829	nickel cation binding
KCX70_RS19060	COG0831	urea catabolic process
KCX70_RS19070	COG0832	Belongs to the urease beta subunit family
KCX70_RS19075	COG0804	urea catabolic process
KCX70_RS19080	COG1953	Uracil, thiamine, allantoin
KCX70_RS19090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KCX70_RS19100	COG2814	Major facilitator Superfamily
KCX70_RS19105	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KCX70_RS19120	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KCX70_RS19125	COG0830	nickel cation binding
KCX70_RS19130	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KCX70_RS19140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KCX70_RS19145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KCX70_RS19150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KCX70_RS19155	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS19165	COG0351	phosphomethylpyrimidine kinase
KCX70_RS19165	COG0352	thiamine-phosphate diphosphorylase activity
KCX70_RS19175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KCX70_RS19190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KCX70_RS19195	COG1702	phosphate starvation-inducible protein PhoH
KCX70_RS19200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KCX70_RS19205	COG4535	Mg2 and Co2 transporter CorC
KCX70_RS19210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KCX70_RS19225	COG0495	leucyl-tRNA aminoacylation
KCX70_RS19245	COG2951	lytic endotransglycosylase activity
KCX70_RS19250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KCX70_RS19255	COG0321	lipoyl(octanoyl) transferase activity
KCX70_RS19260	COG2921	Belongs to the UPF0250 family
KCX70_RS19265	COG1686	Belongs to the peptidase S11 family
KCX70_RS19275	COG2951	lytic endotransglycosylase activity
KCX70_RS19280	COG0772	Belongs to the SEDS family
KCX70_RS19285	COG0768	penicillin binding
KCX70_RS19290	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KCX70_RS19300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KCX70_RS19305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KCX70_RS19310	COG0586	Pfam SNARE associated Golgi protein
KCX70_RS19320	COG1346	cytolysis
KCX70_RS19340	COG0702	epimerase
KCX70_RS19345	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KCX70_RS19355	COG1162	GTPase activity
KCX70_RS19360	COG1360	Flagellar Motor Protein
KCX70_RS19365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KCX70_RS19380	COG0688	phosphatidylethanolamine metabolic process
KCX70_RS19395	COG0560	Phosphoserine phosphatase
KCX70_RS19395	COG3830	Belongs to the UPF0237 family
KCX70_RS19435	COG3150	esterase
KCX70_RS19440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KCX70_RS19450	COG0494	nUDIX hydrolase
KCX70_RS19465	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KCX70_RS19470	COG1538	Outer membrane efflux protein
KCX70_RS19475	COG1519	Transferase
KCX70_RS19490	COG0667	Aldo Keto reductase
KCX70_RS19500	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KCX70_RS19500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KCX70_RS19515	COG1132	(ABC) transporter
KCX70_RS19535	COG3562	capsule polysaccharide
KCX70_RS19545	COG1215	transferase activity, transferring glycosyl groups
KCX70_RS19550	COG2192	nodulation
KCX70_RS19575	COG0438	transferase activity, transferring glycosyl groups
KCX70_RS19585	COG0859	PFAM glycosyl transferase family 9
KCX70_RS19595	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KCX70_RS19620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KCX70_RS19625	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS19630	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS19635	COG3706	GGDEF domain
KCX70_RS19645	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS19675	COG1073	alpha beta
KCX70_RS19675	COG2226	methyltransferase
KCX70_RS19680	COG0156	8-amino-7-oxononanoate synthase activity
KCX70_RS19685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KCX70_RS19690	COG1040	competence protein
KCX70_RS19695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KCX70_RS19700	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KCX70_RS19705	COG2070	2-Nitropropane dioxygenase
KCX70_RS19735	COG1304	FMN binding
KCX70_RS19745	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS19750	COG3263	regulation of cellular component size
KCX70_RS19755	COG1196	nuclear chromosome segregation
KCX70_RS19755	COG3264	Mechanosensitive ion channel
KCX70_RS19760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KCX70_RS19815	COG3842	ATPase activity
KCX70_RS19835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KCX70_RS19840	COG4999	Histidine kinase
KCX70_RS19840	COG3850	Histidine kinase
KCX70_RS19840	COG2205	protein histidine kinase activity
KCX70_RS19840	COG3437	response regulator, receiver
KCX70_RS19865	COG0330	HflC and HflK could
KCX70_RS19950	COG2815	serine threonine protein kinase
KCX70_RS19950	COG0515	serine threonine protein kinase
KCX70_RS20030	COG2204	response regulator
KCX70_RS20050	COG3675	Pfam Lipase (class 3)
KCX70_RS20065	COG1595	DNA-templated transcription, initiation
KCX70_RS20070	COG3712	iron ion homeostasis
KCX70_RS20090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KCX70_RS20105	COG0513	Belongs to the DEAD box helicase family
KCX70_RS20115	COG1289	transmembrane transporter activity
KCX70_RS20120	COG2081	HI0933 family
KCX70_RS20155	COG0745	RESPONSE REGULATOR receiver
KCX70_RS20160	COG0191	fructose-bisphosphate aldolase activity
KCX70_RS20175	COG0126	phosphoglycerate kinase activity
KCX70_RS20185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KCX70_RS20190	COG0583	DNA-binding transcription factor activity
KCX70_RS20195	COG2175	clavaminate synthase activity
KCX70_RS20210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KCX70_RS20220	COG0842	Transport permease protein
KCX70_RS20225	COG1131	(ABC) transporter
KCX70_RS20230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KCX70_RS20255	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KCX70_RS20260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KCX70_RS20265	COG0513	Belongs to the DEAD box helicase family
KCX70_RS20280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KCX70_RS20285	COG2353	YceI-like domain
KCX70_RS20290	COG3038	cytochrome b561
KCX70_RS20300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KCX70_RS20310	COG2201	protein-glutamate methylesterase activity
KCX70_RS20315	COG2198	Histidine kinase
KCX70_RS20315	COG0784	Response regulator, receiver
KCX70_RS20315	COG0643	Histidine kinase
KCX70_RS20355	COG1678	Uncharacterized ACR, COG1678
KCX70_RS20370	COG0540	Belongs to the ATCase OTCase family
KCX70_RS20375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KCX70_RS20420	COG1160	GTP binding
KCX70_RS20425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KCX70_RS20430	COG2813	Specifically methylates the guanine in position
KCX70_RS20430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KCX70_RS20440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KCX70_RS20445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KCX70_RS20470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KCX70_RS20480	COG2188	Transcriptional regulator
KCX70_RS20485	COG2056	Na+-H+ antiporter family
KCX70_RS20490	COG2986	histidine ammonia-lyase
KCX70_RS20500	COG3314	Sporulation integral membrane protein YlbJ
KCX70_RS20505	COG0010	Belongs to the arginase family
KCX70_RS20510	COG1228	amidohydrolase
KCX70_RS20520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KCX70_RS20525	COG2022	thiamine diphosphate biosynthetic process
KCX70_RS20535	COG2363	Small membrane protein
KCX70_RS20540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KCX70_RS20555	COG2177	Part of the ABC transporter FtsEX involved in
KCX70_RS20560	COG2884	Cell division ATP-binding protein ftsE
KCX70_RS20565	COG0552	protein localization to endoplasmic reticulum
KCX70_RS20570	COG0612	Peptidase, M16
KCX70_RS20575	COG0612	Peptidase, M16
KCX70_RS20580	COG0742	ribosomal rna small subunit methyltransferase
KCX70_RS20605	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KCX70_RS20615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KCX70_RS20625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KCX70_RS20630	COG0693	protein deglycase activity
KCX70_RS20640	COG0129	dihydroxy-acid dehydratase activity
KCX70_RS20645	COG2233	PERMEase
KCX70_RS20650	COG2233	PERMEase
KCX70_RS20655	COG0579	oxidoreductase
KCX70_RS20675	COG0584	glycerophosphoryl diester phosphodiesterase
KCX70_RS20680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KCX70_RS20705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KCX70_RS20720	COG0704	Plays a role in the regulation of phosphate uptake
KCX70_RS20725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KCX70_RS20730	COG0573	inorganic phosphate transmembrane transporter activity
KCX70_RS20750	COG5001	Diguanylate cyclase
KCX70_RS20750	COG3706	GGDEF domain
KCX70_RS20750	COG4251	negative regulation of phosphorylation
KCX70_RS20750	COG2203	Gaf domain
KCX70_RS20765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KCX70_RS20770	COG1074	ATP-dependent DNA helicase activity
KCX70_RS20775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KCX70_RS20785	COG1283	sodium-dependent phosphate transmembrane transporter activity
KCX70_RS20795	COG2358	TRAP transporter, solute receptor (TAXI family
KCX70_RS20805	COG0642	Histidine kinase
KCX70_RS20835	COG3180	Ammonia monooxygenase
KCX70_RS20840	COG0700	Nucleoside recognition
KCX70_RS20860	COG2204	response regulator
KCX70_RS20865	COG5002	protein histidine kinase activity
KCX70_RS20875	COG3023	N-Acetylmuramoyl-L-alanine amidase
KCX70_RS20900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KCX70_RS20905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KCX70_RS20905	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KCX70_RS20920	COG1178	ABC-type Fe3 transport system permease component
KCX70_RS20930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KCX70_RS20935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KCX70_RS20940	COG0006	proline dipeptidase activity
KCX70_RS20945	COG3079	Belongs to the UPF0149 family
KCX70_RS20965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KCX70_RS20985	COG0604	alcohol dehydrogenase
KCX70_RS20990	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KCX70_RS21005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KCX70_RS21010	COG4942	peptidase
KCX70_RS21015	COG0793	Belongs to the peptidase S41A family
KCX70_RS21020	COG2861	carbohydrate metabolic process
KCX70_RS21035	COG0107	imidazoleglycerol-phosphate synthase activity
KCX70_RS21040	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KCX70_RS21050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KCX70_RS21055	COG0131	Imidazoleglycerol-phosphate dehydratase
KCX70_RS21070	COG1194	a g-specific adenine glycosylase
KCX70_RS21075	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KCX70_RS21085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KCX70_RS21115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KCX70_RS21140	COG0676	glucose-6-phosphate 1-epimerase activity
KCX70_RS21180	COG0583	DNA-binding transcription factor activity
KCX70_RS21185	COG1027	Aspartate ammonia-lyase
KCX70_RS21195	COG2808	Putative FMN-binding domain
KCX70_RS21215	COG1115	amino acid carrier protein
KCX70_RS21220	COG0252	asparaginase activity
KCX70_RS21225	COG2205	protein histidine kinase activity
KCX70_RS21230	COG1218	3'(2'),5'-bisphosphate nucleotidase
KCX70_RS21235	COG0494	nUDIX hydrolase
KCX70_RS21240	COG1011	Hydrolase
KCX70_RS21250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KCX70_RS21260	COG3383	formate dehydrogenase (NAD+) activity
KCX70_RS21275	COG1910	domain protein
KCX70_RS21285	COG0824	Thioesterase
KCX70_RS21290	COG1454	alcohol dehydrogenase
KCX70_RS21295	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS21300	COG1250	3-hydroxyacyl-CoA dehydrogenase
KCX70_RS21300	COG1024	Enoyl-CoA hydratase
KCX70_RS21355	COG0514	ATP-dependent DNA helicase (RecQ)
KCX70_RS21360	COG0778	Nitroreductase
KCX70_RS21365	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KCX70_RS21375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KCX70_RS21380	COG4067	protein conserved in archaea
KCX70_RS21380	COG0189	ligase activity
KCX70_RS21385	COG0189	ligase activity
KCX70_RS21410	COG1538	Outer membrane efflux protein
KCX70_RS21425	COG3300	MHYT domain
KCX70_RS21425	COG5001	Diguanylate cyclase
KCX70_RS21435	COG2183	response to ionizing radiation
KCX70_RS21445	COG2918	glutathione biosynthetic process
KCX70_RS21450	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KCX70_RS21450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KCX70_RS21460	COG0306	phosphate transporter
KCX70_RS21465	COG1392	Phosphate transport regulator
KCX70_RS21475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KCX70_RS21500	COG1764	response to oxidative stress
KCX70_RS21505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KCX70_RS21530	COG4695	Portal protein
KCX70_RS21785	COG0586	Pfam SNARE associated Golgi protein
KCX70_RS21790	COG2863	cytochrome
KCX70_RS21805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KCX70_RS21810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KCX70_RS21810	COG2010	Cytochrome c
KCX70_RS21825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KCX70_RS21830	COG1127	ABC transporter
KCX70_RS21835	COG3218	ABC-type transport auxiliary lipoprotein component
KCX70_RS21835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KCX70_RS21845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KCX70_RS21850	COG0842	Transport permease protein
KCX70_RS21850	COG1129	ABC transporter
KCX70_RS21855	COG0842	Transport permease protein
KCX70_RS21930	COG1177	transmembrane transport
KCX70_RS21935	COG1176	ABC-type spermidine putrescine transport system, permease component I
KCX70_RS21940	COG3842	ATPase activity
KCX70_RS21965	COG0174	glutamine synthetase
KCX70_RS21970	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KCX70_RS21975	COG0174	glutamine synthetase
KCX70_RS21995	COG2957	Belongs to the agmatine deiminase family
KCX70_RS22000	COG2199	diguanylate cyclase activity
KCX70_RS22010	COG0745	RESPONSE REGULATOR receiver
KCX70_RS22015	COG5002	protein histidine kinase activity
KCX70_RS22020	COG2198	Histidine kinase
KCX70_RS22020	COG0784	Response regulator, receiver
KCX70_RS22020	COG5002	protein histidine kinase activity
KCX70_RS22030	COG5002	protein histidine kinase activity
KCX70_RS22035	COG0745	RESPONSE REGULATOR receiver
KCX70_RS22055	COG1012	belongs to the aldehyde dehydrogenase family
KCX70_RS22060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KCX70_RS22065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KCX70_RS22070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KCX70_RS22090	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS22095	COG1960	acyl-CoA dehydrogenase activity
KCX70_RS22100	COG1250	3-hydroxyacyl-CoA dehydrogenase
KCX70_RS22100	COG1024	Enoyl-CoA hydratase
KCX70_RS22115	COG2851	Citrate transporter
KCX70_RS22130	COG0583	DNA-binding transcription factor activity
KCX70_RS22145	COG3920	Histidine kinase
KCX70_RS22145	COG2202	Pas domain
KCX70_RS22170	COG1304	FMN binding
KCX70_RS22175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KCX70_RS22180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KCX70_RS22200	COG4948	Mandelate Racemase Muconate Lactonizing
KCX70_RS22205	COG1609	Transcriptional regulator
KCX70_RS22210	COG0129	dihydroxy-acid dehydratase activity
KCX70_RS22235	COG1238	metal cluster binding
KCX70_RS22250	COG2358	TRAP transporter, solute receptor (TAXI family
KCX70_RS22275	COG3712	iron ion homeostasis
KCX70_RS22280	COG1595	DNA-templated transcription, initiation
KCX70_RS22295	COG0523	cobalamin synthesis protein
KCX70_RS22310	COG4251	negative regulation of phosphorylation
KCX70_RS22315	COG0784	Response regulator, receiver
KCX70_RS22320	COG4191	Histidine kinase
KCX70_RS22320	COG0784	Response regulator, receiver
KCX70_RS22330	COG0483	inositol monophosphate 1-phosphatase activity
KCX70_RS22340	COG3258	Cytochrome c
KCX70_RS22345	COG2863	cytochrome
KCX70_RS22355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KCX70_RS22370	COG0642	Histidine kinase
KCX70_RS22375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KCX70_RS22395	COG0640	Transcriptional regulator
KCX70_RS22430	COG0789	Transcriptional regulator
KCX70_RS22485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KCX70_RS22485	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KCX70_RS22555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KCX70_RS22620	COG0778	Nitroreductase
KCX70_RS22635	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
KCX70_RS22640	COG1116	anion transmembrane transporter activity
KCX70_RS22645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KCX70_RS22650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KCX70_RS22650	COG1116	anion transmembrane transporter activity
KCX70_RS22655	COG0446	pyridine nucleotide-disulphide oxidoreductase
KCX70_RS22700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KCX70_RS22705	COG1349	DNA-binding transcription factor activity
KCX70_RS22710	COG0840	transmembrane signaling receptor activity
KCX70_RS22715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KCX70_RS22720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KCX70_RS22725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KCX70_RS22730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KCX70_RS22735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KCX70_RS22740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KCX70_RS22745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KCX70_RS22760	COG3312	ion transport
KCX70_RS22765	COG1475	DNA binding
KCX70_RS22770	COG1192	Involved in chromosome partitioning
KCX70_RS22775	COG0357	Ribosomal RNA small subunit methyltransferase G
KCX70_RS22780	COG0445	tRNA wobble uridine modification
KCX70_RS22785	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KCX70_RS22790	COG0706	membrane insertase activity
KCX70_RS22795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KCX70_RS22800	COG0594	ribonuclease P activity
KCX70_RS22805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KCX70_RS23065	COG1724	mRNA binding
KCX70_RS23070	COG1598	PFAM Uncharacterised protein family UPF0150
KCX70_RS23185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KCX70_RS23245	COG1201	RNA secondary structure unwinding
KCX70_RS23260	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KCX70_RS23325	COG1278	Cold shock