locus-tag	class	description
I6I22_RS00020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I22_RS00040	COG4774	siderophore transport
I6I22_RS00045	COG2721	sulfolactate sulfo-lyase activity
I6I22_RS00055	COG1012	belongs to the aldehyde dehydrogenase family
I6I22_RS00060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I22_RS00065	COG4948	Mandelate Racemase Muconate Lactonizing
I6I22_RS00090	COG0583	DNA-binding transcription factor activity
I6I22_RS00115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I22_RS00125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I22_RS00145	COG3932	Exopolysaccharide synthesis, ExoD
I6I22_RS00150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I22_RS00155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I22_RS00220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I22_RS00235	COG0513	Belongs to the DEAD box helicase family
I6I22_RS00240	COG1289	transmembrane transporter activity
I6I22_RS00250	COG2081	HI0933 family
I6I22_RS00290	COG0191	fructose-bisphosphate aldolase activity
I6I22_RS00305	COG0126	phosphoglycerate kinase activity
I6I22_RS00310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I22_RS00315	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I22_RS00320	COG0583	DNA-binding transcription factor activity
I6I22_RS00325	COG2175	clavaminate synthase activity
I6I22_RS00335	COG2226	methyltransferase
I6I22_RS00340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I22_RS00350	COG0842	Transport permease protein
I6I22_RS00355	COG1131	(ABC) transporter
I6I22_RS00360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I22_RS00365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I22_RS00385	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I22_RS00390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I22_RS00395	COG0513	Belongs to the DEAD box helicase family
I6I22_RS00410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I22_RS00415	COG2353	YceI-like domain
I6I22_RS00420	COG3038	cytochrome b561
I6I22_RS00430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I22_RS00440	COG2201	protein-glutamate methylesterase activity
I6I22_RS00445	COG0643	Histidine kinase
I6I22_RS00445	COG0784	Response regulator, receiver
I6I22_RS00445	COG2198	Histidine kinase
I6I22_RS00485	COG1678	Uncharacterized ACR, COG1678
I6I22_RS00490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I22_RS00500	COG0540	Belongs to the ATCase OTCase family
I6I22_RS00505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I22_RS00555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I22_RS00560	COG2813	Specifically methylates the guanine in position
I6I22_RS00560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I22_RS00570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I22_RS00575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I22_RS00595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I22_RS00600	COG2022	thiamine diphosphate biosynthetic process
I6I22_RS00610	COG2363	Small membrane protein
I6I22_RS00615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I22_RS00635	COG2177	Part of the ABC transporter FtsEX involved in
I6I22_RS00640	COG2884	Cell division ATP-binding protein ftsE
I6I22_RS00645	COG0552	protein localization to endoplasmic reticulum
I6I22_RS00650	COG0612	Peptidase, M16
I6I22_RS00655	COG0612	Peptidase, M16
I6I22_RS00660	COG0742	ribosomal rna small subunit methyltransferase
I6I22_RS00690	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I22_RS00700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I22_RS00720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I22_RS00730	COG0693	protein deglycase activity
I6I22_RS00735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I22_RS00745	COG0129	dihydroxy-acid dehydratase activity
I6I22_RS00755	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I22_RS00755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I22_RS00775	COG0584	glycerophosphoryl diester phosphodiesterase
I6I22_RS00785	COG1160	GTP binding
I6I22_RS00800	COG0704	Plays a role in the regulation of phosphate uptake
I6I22_RS00805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I22_RS00810	COG0573	inorganic phosphate transmembrane transporter activity
I6I22_RS00825	COG1607	acyl-coa hydrolase
I6I22_RS00830	COG5001	Diguanylate cyclase
I6I22_RS00830	COG3447	MASE1 domain protein
I6I22_RS00830	COG5002	protein histidine kinase activity
I6I22_RS00845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I22_RS00850	COG1074	ATP-dependent DNA helicase activity
I6I22_RS00855	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I22_RS00865	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I22_RS00870	COG3180	Ammonia monooxygenase
I6I22_RS00910	COG5001	Diguanylate cyclase
I6I22_RS00910	COG4251	negative regulation of phosphorylation
I6I22_RS00910	COG3706	GGDEF domain
I6I22_RS00910	COG2203	Gaf domain
I6I22_RS00915	COG0840	transmembrane signaling receptor activity
I6I22_RS00925	COG0840	transmembrane signaling receptor activity
I6I22_RS00930	COG2358	TRAP transporter, solute receptor (TAXI family
I6I22_RS00940	COG0700	Nucleoside recognition
I6I22_RS00960	COG2204	response regulator
I6I22_RS00965	COG5002	protein histidine kinase activity
I6I22_RS00975	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I22_RS01000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I22_RS01005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I22_RS01005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I22_RS01020	COG1178	ABC-type Fe3 transport system permease component
I6I22_RS01030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I22_RS01040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I22_RS01045	COG0006	proline dipeptidase activity
I6I22_RS01050	COG3079	Belongs to the UPF0149 family
I6I22_RS01070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I22_RS01095	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6I22_RS01105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I22_RS01110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I22_RS01115	COG4942	peptidase
I6I22_RS01120	COG0793	Belongs to the peptidase S41A family
I6I22_RS01140	COG0107	imidazoleglycerol-phosphate synthase activity
I6I22_RS01145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I22_RS01160	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I22_RS01165	COG3707	response regulator
I6I22_RS01170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I22_RS01180	COG1116	anion transmembrane transporter activity
I6I22_RS01195	COG1194	a g-specific adenine glycosylase
I6I22_RS01200	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6I22_RS01245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I22_RS01255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I22_RS01270	COG0676	glucose-6-phosphate 1-epimerase activity
I6I22_RS01325	COG2204	response regulator
I6I22_RS01365	COG3220	belongs to the UPF0276 family
I6I22_RS01375	COG1595	DNA-templated transcription, initiation
I6I22_RS01380	COG4944	Protein of unknown function (DUF1109)
I6I22_RS01395	COG0840	transmembrane signaling receptor activity
I6I22_RS01410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I22_RS01430	COG3052	prosthetic group binding
I6I22_RS01435	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6I22_RS01445	COG4221	oxidoreductase activity
I6I22_RS01455	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6I22_RS01460	COG3639	organic phosphonate transmembrane transporter activity
I6I22_RS01465	COG2188	Transcriptional regulator
I6I22_RS01470	COG3624	Phosphonate C-P lyase system protein PhnG
I6I22_RS01480	COG3626	phosphonate metabolism
I6I22_RS01485	COG3627	carbon phosphorus lyase activity
I6I22_RS01490	COG4107	phosphonate C-P lyase system protein PhnK
I6I22_RS01495	COG4778	phosphonate C-P lyase system protein PhnL
I6I22_RS01500	COG3454	Phosphonate metabolism
I6I22_RS01510	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I22_RS01525	COG2358	TRAP transporter, solute receptor (TAXI family
I6I22_RS01565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I22_RS01575	COG3360	Dodecin
I6I22_RS01580	COG4249	Peptidase C14 caspase catalytic subunit p20
I6I22_RS01585	COG1132	(ABC) transporter
I6I22_RS01605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I22_RS01630	COG0159	tryptophan synthase activity
I6I22_RS01650	COG3550	peptidyl-serine autophosphorylation
I6I22_RS01655	COG1396	sequence-specific DNA binding
I6I22_RS01660	COG0625	glutathione transferase activity
I6I22_RS01695	COG1132	(ABC) transporter
I6I22_RS01710	COG1476	TRANSCRIPTIONal
I6I22_RS01735	COG2323	membrane
I6I22_RS01740	COG0583	DNA-binding transcription factor activity
I6I22_RS01795	COG1686	Belongs to the peptidase S11 family
I6I22_RS01810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I22_RS01815	COG0408	coproporphyrinogen oxidase activity
I6I22_RS01825	COG0009	L-threonylcarbamoyladenylate synthase
I6I22_RS01830	COG0758	DNA mediated transformation
I6I22_RS01835	COG1652	LysM domain
I6I22_RS01840	COG0242	peptide deformylase activity
I6I22_RS01845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I22_RS01850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I22_RS01855	COG0569	domain protein
I6I22_RS01860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I22_RS01865	COG0765	amino acid transport
I6I22_RS01870	COG0765	amino acid transport
I6I22_RS01875	COG1126	abc transporter atp-binding protein
I6I22_RS01895	COG2818	Glycosylase
I6I22_RS01905	COG0751	glycine-tRNA ligase activity
I6I22_RS01920	COG3706	GGDEF domain
I6I22_RS01935	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I22_RS01940	COG0592	DNA-directed DNA polymerase activity
I6I22_RS01945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I22_RS01950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I22_RS01955	COG0594	ribonuclease P activity
I6I22_RS01960	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I22_RS01965	COG0706	membrane insertase activity
I6I22_RS01970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I22_RS01975	COG0445	tRNA wobble uridine modification
I6I22_RS01980	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I22_RS01985	COG1192	Involved in chromosome partitioning
I6I22_RS01990	COG1475	DNA binding
I6I22_RS01995	COG3312	ion transport
I6I22_RS02000	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I22_RS02010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I22_RS02015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I22_RS02020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I22_RS02025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I22_RS02030	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I22_RS02035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I22_RS02040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I22_RS02045	COG1349	DNA-binding transcription factor activity
I6I22_RS02050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I22_RS02060	COG4191	Histidine kinase
I6I22_RS02060	COG0784	Response regulator, receiver
I6I22_RS02065	COG0784	Response regulator, receiver
I6I22_RS02070	COG4251	negative regulation of phosphorylation
I6I22_RS02085	COG0523	cobalamin synthesis protein
I6I22_RS02100	COG1595	DNA-templated transcription, initiation
I6I22_RS02125	COG0109	protoheme IX farnesyltransferase activity
I6I22_RS02130	COG1612	heme a metabolic process
I6I22_RS02155	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I6I22_RS02160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I22_RS02165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I22_RS02175	COG0659	secondary active sulfate transmembrane transporter activity
I6I22_RS02205	COG0339	signal peptide processing
I6I22_RS02210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I22_RS02230	COG2011	ABC-type metal ion transport system permease component
I6I22_RS02245	COG0471	metal ion transport
I6I22_RS02250	COG1451	nucleotide metabolic process
I6I22_RS02255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I22_RS02260	COG1121	(ABC) transporter
I6I22_RS02265	COG0735	belongs to the Fur family
I6I22_RS02275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I22_RS02280	COG1012	belongs to the aldehyde dehydrogenase family
I6I22_RS02300	COG0745	RESPONSE REGULATOR receiver
I6I22_RS02305	COG2205	protein histidine kinase activity
I6I22_RS02305	COG0784	Response regulator, receiver
I6I22_RS02305	COG5002	protein histidine kinase activity
I6I22_RS02315	COG0745	RESPONSE REGULATOR receiver
I6I22_RS02320	COG5002	protein histidine kinase activity
I6I22_RS02325	COG0745	RESPONSE REGULATOR receiver
I6I22_RS02330	COG4191	Histidine kinase
I6I22_RS02340	COG3706	GGDEF domain
I6I22_RS02350	COG2957	Belongs to the agmatine deiminase family
I6I22_RS02365	COG0174	glutamine synthetase
I6I22_RS02370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6I22_RS02375	COG0174	glutamine synthetase
I6I22_RS02395	COG3842	ATPase activity
I6I22_RS02400	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I22_RS02405	COG1177	transmembrane transport
I6I22_RS02415	COG1116	anion transmembrane transporter activity
I6I22_RS02430	COG4771	TonB-dependent receptor
I6I22_RS02500	COG0842	Transport permease protein
I6I22_RS02505	COG1129	ABC transporter
I6I22_RS02505	COG0842	Transport permease protein
I6I22_RS02510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I22_RS02525	COG1127	ABC transporter
I6I22_RS02530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I22_RS02535	COG0753	catalase activity
I6I22_RS02540	COG2010	Cytochrome c
I6I22_RS02560	COG0515	serine threonine protein kinase
I6I22_RS02605	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6I22_RS02610	COG3909	cytochrome
I6I22_RS02625	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I22_RS02625	COG1024	Enoyl-CoA hydratase
I6I22_RS02630	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS02635	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS02655	COG2814	Major facilitator Superfamily
I6I22_RS02675	COG0318	PFAM AMP-dependent synthetase and ligase
I6I22_RS02680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I22_RS02685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I22_RS02690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I22_RS02705	COG1611	Belongs to the LOG family
I6I22_RS02710	COG4589	Belongs to the CDS family
I6I22_RS02720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I22_RS02795	COG2207	Transcriptional regulator
I6I22_RS02805	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I22_RS02875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I22_RS02880	COG0583	DNA-binding transcription factor activity
I6I22_RS02905	COG2264	protein methyltransferase activity
I6I22_RS02930	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I22_RS02965	COG1677	Flagellar hook-basal body complex protein FliE
I6I22_RS02975	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I22_RS03005	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6I22_RS03030	COG1191	sigma factor activity
I6I22_RS03035	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6I22_RS03055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6I22_RS03065	COG1815	bacterial-type flagellum-dependent cell motility
I6I22_RS03070	COG1558	bacterial-type flagellum-dependent cell motility
I6I22_RS03075	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6I22_RS03085	COG4787	bacterial-type flagellum-dependent cell motility
I6I22_RS03090	COG4786	Flagellar basal body rod
I6I22_RS03095	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6I22_RS03100	COG1706	bacterial-type flagellum-dependent cell motility
I6I22_RS03105	COG0741	lytic transglycosylase activity
I6I22_RS03110	COG4786	Flagellar basal body rod
I6I22_RS03110	COG1256	bacterial-type flagellum assembly
I6I22_RS03125	COG2706	6-phosphogluconolactonase activity
I6I22_RS03130	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS03135	COG0784	Response regulator, receiver
I6I22_RS03135	COG4191	Histidine kinase
I6I22_RS03160	COG3795	YCII-related domain
I6I22_RS03165	COG4941	Belongs to the sigma-70 factor family
I6I22_RS03170	COG2204	response regulator
I6I22_RS03185	COG0659	secondary active sulfate transmembrane transporter activity
I6I22_RS03190	COG0589	response to stress
I6I22_RS03195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I22_RS03205	COG0509	glycine decarboxylation via glycine cleavage system
I6I22_RS03285	COG4128	Pfam Zonular occludens toxin
I6I22_RS03345	COG3276	selenocysteine insertion sequence binding
I6I22_RS03350	COG1921	L-seryl-tRNASec selenium transferase activity
I6I22_RS03355	COG3058	Necessary for formate dehydrogenase activity
I6I22_RS03360	COG2864	formate dehydrogenase
I6I22_RS03365	COG0437	4 iron, 4 sulfur cluster binding
I6I22_RS03380	COG1764	response to oxidative stress
I6I22_RS03395	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I22_RS03400	COG0210	DNA helicase
I6I22_RS03410	COG0826	peptidase U32
I6I22_RS03415	COG2841	Protein conserved in bacteria
I6I22_RS03420	COG0527	aspartate kinase activity
I6I22_RS03425	COG5285	phytanoyl-CoA dioxygenase
I6I22_RS03430	COG1917	Cupin 2, conserved barrel domain protein
I6I22_RS03435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I22_RS03445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I22_RS03450	COG0837	glucose binding
I6I22_RS03450	COG1737	Transcriptional regulator
I6I22_RS03460	COG0583	DNA-binding transcription factor activity
I6I22_RS03465	COG0439	Biotin carboxylase
I6I22_RS03470	COG5016	pyruvate
I6I22_RS03470	COG0511	ligase activity, forming carbon-carbon bonds
I6I22_RS03485	COG2066	Belongs to the glutaminase family
I6I22_RS03500	COG0252	asparaginase activity
I6I22_RS03505	COG1115	amino acid carrier protein
I6I22_RS03540	COG0583	DNA-binding transcription factor activity
I6I22_RS03545	COG0318	PFAM AMP-dependent synthetase and ligase
I6I22_RS03550	COG1082	Xylose isomerase domain protein TIM barrel
I6I22_RS03550	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6I22_RS03555	COG2205	protein histidine kinase activity
I6I22_RS03585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I22_RS03590	COG0436	Aminotransferase
I6I22_RS03595	COG2258	MOSC domain
I6I22_RS03615	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6I22_RS03620	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6I22_RS03630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I22_RS03650	COG0583	DNA-binding transcription factor activity
I6I22_RS03655	COG2814	Major facilitator Superfamily
I6I22_RS03680	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I22_RS03685	COG1764	response to oxidative stress
I6I22_RS03700	COG2989	Protein conserved in bacteria
I6I22_RS03710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I22_RS03720	COG1392	Phosphate transport regulator
I6I22_RS03725	COG0306	phosphate transporter
I6I22_RS03740	COG2918	glutathione biosynthetic process
I6I22_RS03750	COG2183	response to ionizing radiation
I6I22_RS03755	COG0457	Tetratricopeptide repeat
I6I22_RS03755	COG3118	belongs to the thioredoxin family
I6I22_RS03760	COG1215	transferase activity, transferring glycosyl groups
I6I22_RS03765	COG1215	transferase activity, transferring glycosyl groups
I6I22_RS03770	COG1192	Involved in chromosome partitioning
I6I22_RS03780	COG2194	sulfuric ester hydrolase activity
I6I22_RS03810	COG0189	ligase activity
I6I22_RS03815	COG4067	protein conserved in archaea
I6I22_RS03815	COG0189	ligase activity
I6I22_RS03820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I22_RS03825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I22_RS03835	COG0778	Nitroreductase
I6I22_RS03840	COG0514	ATP-dependent DNA helicase (RecQ)
I6I22_RS03845	COG0840	transmembrane signaling receptor activity
I6I22_RS03850	COG0840	transmembrane signaling receptor activity
I6I22_RS03860	COG0667	Aldo Keto reductase
I6I22_RS03885	COG1278	Cold shock
I6I22_RS03890	COG0784	Response regulator, receiver
I6I22_RS03890	COG4191	Histidine kinase
I6I22_RS03895	COG2205	protein histidine kinase activity
I6I22_RS03905	COG2172	sigma factor antagonist activity
I6I22_RS03910	COG1366	Belongs to the anti-sigma-factor antagonist family
I6I22_RS03915	COG1366	Belongs to the anti-sigma-factor antagonist family
I6I22_RS03925	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I22_RS03925	COG1024	Enoyl-CoA hydratase
I6I22_RS03930	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS03935	COG1454	alcohol dehydrogenase
I6I22_RS03955	COG4191	Histidine kinase
I6I22_RS03955	COG0784	Response regulator, receiver
I6I22_RS03960	COG1011	Hydrolase
I6I22_RS03965	COG0494	nUDIX hydrolase
I6I22_RS03970	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I22_RS03985	COG0058	SHG alpha-glucan phosphorylase activity
I6I22_RS03990	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I22_RS04020	COG1490	D-aminoacyl-tRNA deacylase activity
I6I22_RS04040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I22_RS04045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I22_RS04050	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I22_RS04055	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I22_RS04060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I22_RS04070	COG2226	methyltransferase
I6I22_RS04085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I22_RS04095	COG0243	molybdopterin cofactor binding
I6I22_RS04115	COG3852	Histidine kinase
I6I22_RS04135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I22_RS04135	COG0301	tRNA thio-modification
I6I22_RS04140	COG1217	gtp-binding protein TYPA
I6I22_RS04150	COG3493	citrate carrier protein
I6I22_RS04155	COG3290	protein histidine kinase activity
I6I22_RS04160	COG4565	transcriptional regulatory protein
I6I22_RS04175	COG2819	hydrolase of the alpha beta superfamily
I6I22_RS04190	COG2207	Transcriptional regulator
I6I22_RS04200	COG4251	negative regulation of phosphorylation
I6I22_RS04200	COG2203	Gaf domain
I6I22_RS04200	COG5001	Diguanylate cyclase
I6I22_RS04200	COG3706	GGDEF domain
I6I22_RS04225	COG2204	response regulator
I6I22_RS04230	COG4807	Protein conserved in bacteria
I6I22_RS04255	COG5001	Diguanylate cyclase
I6I22_RS04260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6I22_RS04285	COG1320	monovalent cation:proton antiporter activity
I6I22_RS04305	COG0651	ATP synthesis coupled electron transport
I6I22_RS04310	COG0651	ATP synthesis coupled electron transport
I6I22_RS04335	COG2197	response regulator
I6I22_RS04360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I22_RS04365	COG0277	FAD linked oxidase domain protein
I6I22_RS04370	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I22_RS04390	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I22_RS04395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I22_RS04410	COG0494	nUDIX hydrolase
I6I22_RS04425	COG0730	response to heat
I6I22_RS04430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I22_RS04435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I22_RS04440	COG1192	Involved in chromosome partitioning
I6I22_RS04450	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I22_RS04460	COG0411	ABC transporter
I6I22_RS04480	COG0739	heme binding
I6I22_RS04490	COG1253	flavin adenine dinucleotide binding
I6I22_RS04505	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I22_RS04515	COG2186	Transcriptional regulator
I6I22_RS04520	COG0277	FAD linked oxidase domain protein
I6I22_RS04525	COG0277	FAD linked oxidase domain protein
I6I22_RS04530	COG0247	lactate metabolic process
I6I22_RS04535	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6I22_RS04540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I22_RS04545	COG1620	l-lactate permease
I6I22_RS04570	COG0583	DNA-binding transcription factor activity
I6I22_RS04575	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS04590	COG0583	DNA-binding transcription factor activity
I6I22_RS04595	COG1704	LemA family
I6I22_RS04600	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6I22_RS04620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I22_RS04645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I22_RS04650	COG1758	RNA polymerase activity
I6I22_RS04660	COG1561	YicC-like family, N-terminal region
I6I22_RS04665	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I22_RS04675	COG0708	Exodeoxyribonuclease III
I6I22_RS04680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I22_RS04695	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I22_RS04705	COG0756	dUTP diphosphatase activity
I6I22_RS04710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I22_RS04715	COG2003	Belongs to the UPF0758 family
I6I22_RS04730	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I22_RS04735	COG0840	transmembrane signaling receptor activity
I6I22_RS04750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I22_RS04755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I22_RS04765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I22_RS04790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I22_RS04805	COG0366	Alpha amylase catalytic
I6I22_RS04820	COG1454	alcohol dehydrogenase
I6I22_RS04830	COG1414	Transcriptional regulator
I6I22_RS04835	COG1272	protein, Hemolysin III
I6I22_RS04840	COG0210	DNA helicase
I6I22_RS04850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I22_RS04855	COG0606	chelatase, subunit chli
I6I22_RS04865	COG0347	Belongs to the P(II) protein family
I6I22_RS04870	COG0004	ammonium transporteR
I6I22_RS04875	COG0004	ammonium transporteR
I6I22_RS04880	COG0432	Pfam Uncharacterised protein family UPF0047
I6I22_RS04895	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I22_RS04905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I22_RS04920	COG1965	Belongs to the frataxin family
I6I22_RS04925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I22_RS04960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I22_RS04965	COG0165	Argininosuccinate lyase
I6I22_RS04970	COG3275	phosphorelay sensor kinase activity
I6I22_RS05000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I22_RS05020	COG0488	(ABC) transporter
I6I22_RS05030	COG0861	Integral membrane protein TerC family
I6I22_RS05035	COG1280	lysine exporter protein (LysE YggA)
I6I22_RS05040	COG1671	Belongs to the UPF0178 family
I6I22_RS05055	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6I22_RS05065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I22_RS05070	COG0248	Ppx GppA phosphatase
I6I22_RS05085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6I22_RS05100	COG0018	arginyl-trna synthetase
I6I22_RS05105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I22_RS05110	COG0254	rRNA binding
I6I22_RS05120	COG0281	malic enzyme
I6I22_RS05155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I22_RS05160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I22_RS05170	COG0070	glutamate synthase
I6I22_RS05170	COG0067	glutamate synthase
I6I22_RS05170	COG0069	glutamate synthase activity
I6I22_RS05175	COG0493	'glutamate synthase
I6I22_RS05185	COG2814	Major facilitator Superfamily
I6I22_RS05190	COG0583	DNA-binding transcription factor activity
I6I22_RS05215	COG3118	belongs to the thioredoxin family
I6I22_RS05220	COG2873	o-acetylhomoserine
I6I22_RS05225	COG0471	metal ion transport
I6I22_RS05225	COG3273	potassium ion transport
I6I22_RS05235	COG1715	Restriction endonuclease
I6I22_RS05270	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6I22_RS05295	COG5642	Protein of unknown function (DUF2384)
I6I22_RS05360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I22_RS05365	COG0358	DNA primase activity
I6I22_RS05370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I22_RS05375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I22_RS05380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I22_RS05400	COG2719	SpoVR family
I6I22_RS05405	COG2718	Belongs to the UPF0229 family
I6I22_RS05410	COG2766	serine protein kinase
I6I22_RS05415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I22_RS05420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I22_RS05425	COG2967	ApaG domain
I6I22_RS05430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I22_RS05435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I22_RS05440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I22_RS05445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I22_RS05455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I22_RS05460	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I22_RS05475	COG2197	response regulator
I6I22_RS05480	COG3842	ATPase activity
I6I22_RS05490	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I22_RS05505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I22_RS05510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I22_RS05515	COG0546	phosphoglycolate phosphatase activity
I6I22_RS05525	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I22_RS05530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I22_RS05535	COG0134	indole-3-glycerol-phosphate synthase activity
I6I22_RS05545	COG1765	OsmC-like protein
I6I22_RS05555	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6I22_RS05560	COG0537	adenosine 5'-monophosphoramidase activity
I6I22_RS05565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I22_RS05575	COG1981	membrane
I6I22_RS05580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I22_RS05585	COG0316	Belongs to the HesB IscA family
I6I22_RS05590	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I22_RS05595	COG0739	heme binding
I6I22_RS05600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I22_RS05630	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I22_RS05630	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I22_RS05635	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6I22_RS05660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I22_RS05680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I22_RS05685	COG0081	regulation of translation
I6I22_RS05695	COG0222	ribosome binding
I6I22_RS05700	COG0085	RNA polymerase activity
I6I22_RS05705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I22_RS05710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I22_RS05715	COG0049	tRNA binding
I6I22_RS05720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I22_RS05725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I22_RS05730	COG0051	transcription antitermination factor activity, RNA binding
I6I22_RS05735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I22_RS05740	COG0088	Forms part of the polypeptide exit tunnel
I6I22_RS05745	COG0089	rRNA binding
I6I22_RS05750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I22_RS05755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I22_RS05760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I22_RS05765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I22_RS05770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I22_RS05775	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I22_RS05780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I22_RS05785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I22_RS05790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I22_RS05795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I22_RS05800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I22_RS05805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I22_RS05810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I22_RS05820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I22_RS05825	COG1841	ribosomal large subunit assembly
I6I22_RS05830	COG0200	Binds to the 23S rRNA
I6I22_RS05840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I22_RS05845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I22_RS05850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I22_RS05855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I22_RS05860	COG0202	RNA polymerase activity
I6I22_RS05865	COG0203	ribosomal protein L17
I6I22_RS05870	COG0753	catalase activity
I6I22_RS05885	COG2814	Major facilitator Superfamily
I6I22_RS05900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I22_RS05905	COG3047	cAMP biosynthetic process
I6I22_RS05915	COG0811	peptide transport
I6I22_RS05920	COG0811	peptide transport
I6I22_RS05925	COG0848	biopolymer transport protein
I6I22_RS05950	COG4181	ATPase activity
I6I22_RS05965	COG3118	belongs to the thioredoxin family
I6I22_RS05975	COG2264	protein methyltransferase activity
I6I22_RS05990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I22_RS05990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I22_RS06005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I22_RS06010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I22_RS06020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I22_RS06025	COG3577	Aspartyl protease
I6I22_RS06030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I22_RS06045	COG4206	TonB-dependent receptor
I6I22_RS06055	COG0420	3'-5' exonuclease activity
I6I22_RS06105	COG0564	pseudouridine synthase activity
I6I22_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS06125	COG4829	muconolactone delta-isomerase
I6I22_RS06130	COG2031	fatty acid transporter
I6I22_RS06145	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS06150	COG2610	gluconate transmembrane transporter activity
I6I22_RS06155	COG2031	fatty acid transporter
I6I22_RS06165	COG1522	sequence-specific DNA binding
I6I22_RS06180	COG0733	neurotransmitter:sodium symporter activity
I6I22_RS06190	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6I22_RS06200	COG0625	glutathione transferase activity
I6I22_RS06205	COG0733	neurotransmitter:sodium symporter activity
I6I22_RS06225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I22_RS06225	COG4651	solute:proton antiporter activity
I6I22_RS06230	COG0513	Belongs to the DEAD box helicase family
I6I22_RS06255	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6I22_RS06265	COG1946	Acyl-CoA thioesterase
I6I22_RS06275	COG2321	neutral zinc metallopeptidase
I6I22_RS06300	COG2197	response regulator
I6I22_RS06305	COG3850	Histidine kinase
I6I22_RS06320	COG2223	nitrite transmembrane transporter activity
I6I22_RS06325	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6I22_RS06330	COG1140	nitrate reductase beta subunit
I6I22_RS06335	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6I22_RS06340	COG2181	nitrate reductase activity
I6I22_RS06355	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I22_RS06360	COG0303	'Molybdopterin
I6I22_RS06365	COG3038	cytochrome b561
I6I22_RS06420	COG3642	lipopolysaccharide core region biosynthetic process
I6I22_RS06445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I22_RS06450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I22_RS06455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I22_RS06460	COG2252	PERMEase
I6I22_RS06470	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6I22_RS06470	COG3608	succinylglutamate desuccinylase aspartoacylase
I6I22_RS06480	COG2080	2 iron, 2 sulfur cluster binding
I6I22_RS06485	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6I22_RS06490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I22_RS06500	COG0789	Transcriptional regulator
I6I22_RS06505	COG2813	Specifically methylates the guanine in position
I6I22_RS06540	COG0488	(ABC) transporter
I6I22_RS06545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I22_RS06575	COG1970	mechanosensitive ion channel activity
I6I22_RS06585	COG1067	ATP-dependent peptidase activity
I6I22_RS06595	COG2862	Uncharacterized protein family, UPF0114
I6I22_RS06605	COG3046	protein related to deoxyribodipyrimidine photolyase
I6I22_RS06615	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I22_RS06625	COG0142	geranyltranstransferase activity
I6I22_RS06630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I22_RS06635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I22_RS06640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I22_RS06645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I22_RS06650	COG3045	CreA protein
I6I22_RS06655	COG0268	Binds directly to 16S ribosomal RNA
I6I22_RS06665	COG0196	riboflavin kinase activity
I6I22_RS06670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I22_RS06675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I22_RS06680	COG1047	Peptidyl-prolyl cis-trans
I6I22_RS06685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I22_RS06730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I22_RS06735	COG0023	Translation Initiation Factor
I6I22_RS06740	COG1166	arginine decarboxylase activity
I6I22_RS06750	COG0534	Mate efflux family protein
I6I22_RS06780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I22_RS06795	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I22_RS06795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I22_RS06800	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I22_RS06805	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I22_RS06805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I22_RS06805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I22_RS06810	COG4993	Dehydrogenase
I6I22_RS06815	COG2852	Protein conserved in bacteria
I6I22_RS06820	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I22_RS06825	COG0019	diaminopimelate decarboxylase activity
I6I22_RS06835	COG3128	pkhd-type hydroxylase
I6I22_RS06840	COG4774	siderophore transport
I6I22_RS06845	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I22_RS06865	COG4771	TonB-dependent receptor
I6I22_RS06880	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6I22_RS06890	COG0739	heme binding
I6I22_RS06905	COG0530	calcium, potassium:sodium antiporter activity
I6I22_RS06910	COG0530	calcium, potassium:sodium antiporter activity
I6I22_RS06915	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I22_RS06920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I22_RS06935	COG1077	Cell shape determining protein MreB Mrl
I6I22_RS06940	COG1792	Involved in formation and maintenance of cell shape
I6I22_RS06960	COG1530	ribonuclease E activity
I6I22_RS06970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I22_RS06975	COG0312	modulator of DNA gyrase
I6I22_RS06985	COG0312	modulator of DNA gyrase
I6I22_RS06995	COG1660	Displays ATPase and GTPase activities
I6I22_RS07010	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I22_RS07015	COG1137	ATPase activity
I6I22_RS07030	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I22_RS07040	COG1127	ABC transporter
I6I22_RS07045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I22_RS07050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I22_RS07075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I22_RS07080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I22_RS07090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I22_RS07095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I22_RS07105	COG0175	sulfate reduction
I6I22_RS07115	COG1131	(ABC) transporter
I6I22_RS07155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6I22_RS07160	COG0237	dephospho-CoA kinase activity
I6I22_RS07175	COG0667	Aldo Keto reductase
I6I22_RS07180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I22_RS07185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I22_RS07190	COG0723	plastoquinol--plastocyanin reductase activity
I6I22_RS07195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6I22_RS07200	COG2857	Cytochrome c1
I6I22_RS07205	COG0625	glutathione transferase activity
I6I22_RS07210	COG2969	positive regulation of protein catabolic process
I6I22_RS07215	COG2823	Periplasmic or secreted lipoprotein
I6I22_RS07220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I22_RS07225	COG0792	nuclease activity
I6I22_RS07250	COG0275	rRNA processing
I6I22_RS07265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I22_RS07270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I22_RS07275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I22_RS07280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I22_RS07285	COG0772	Belongs to the SEDS family
I6I22_RS07290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I22_RS07295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I22_RS07300	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I22_RS07345	COG1285	pathogenesis
I6I22_RS07370	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS07375	COG0659	secondary active sulfate transmembrane transporter activity
I6I22_RS07430	COG0840	transmembrane signaling receptor activity
I6I22_RS07435	COG0501	Belongs to the peptidase M48B family
I6I22_RS07445	COG2119	membrane
I6I22_RS07450	COG2813	Specifically methylates the guanine in position
I6I22_RS07455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I22_RS07460	COG1280	lysine exporter protein (LysE YggA)
I6I22_RS07465	COG0318	PFAM AMP-dependent synthetase and ligase
I6I22_RS07470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I22_RS07475	COG2885	chlorophyll binding
I6I22_RS07480	COG2205	protein histidine kinase activity
I6I22_RS07480	COG0784	Response regulator, receiver
I6I22_RS07490	COG0204	Acyl-transferase
I6I22_RS07500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I22_RS07510	COG0386	Belongs to the glutathione peroxidase family
I6I22_RS07515	COG1309	transcriptional regulator
I6I22_RS07525	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I6I22_RS07540	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I22_RS07585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I22_RS07590	COG0693	protein deglycase activity
I6I22_RS07595	COG4628	conserved protein (DUF2132)
I6I22_RS07610	COG3706	GGDEF domain
I6I22_RS07645	COG0714	Associated with various cellular activities
I6I22_RS07670	COG2925	Exonuclease
I6I22_RS07680	COG0788	formyltetrahydrofolate deformylase activity
I6I22_RS07690	COG0433	COG0433 Predicted ATPase
I6I22_RS07705	COG3022	response to hydroperoxide
I6I22_RS07715	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6I22_RS07720	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I22_RS07725	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6I22_RS07745	COG0400	carboxylic ester hydrolase activity
I6I22_RS07750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I22_RS07755	COG4597	amino acid ABC transporter
I6I22_RS07760	COG0765	amino acid transport
I6I22_RS07765	COG1126	abc transporter atp-binding protein
I6I22_RS07770	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I22_RS07770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I22_RS07780	COG3034	peptidoglycan biosynthetic process
I6I22_RS07805	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I22_RS07810	COG4536	flavin adenine dinucleotide binding
I6I22_RS07815	COG4137	Cytochrome C assembly protein
I6I22_RS07820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I22_RS07825	COG0228	four-way junction DNA binding
I6I22_RS07830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I22_RS07835	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I22_RS07840	COG0335	large ribosomal subunit rRNA binding
I6I22_RS07845	COG4974	Belongs to the 'phage' integrase family
I6I22_RS07855	COG3791	Glutathione-dependent formaldehyde-activating
I6I22_RS07870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I22_RS07875	COG0418	dihydroorotase activity
I6I22_RS07885	COG0137	argininosuccinate synthase activity
I6I22_RS07890	COG0346	lactoylglutathione lyase activity
I6I22_RS07900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I22_RS07910	COG4659	FMN binding
I6I22_RS07915	COG4658	electron transport chain
I6I22_RS07925	COG2878	Part of a membrane complex involved in electron transport
I6I22_RS07930	COG4657	Part of a membrane complex involved in electron transport
I6I22_RS07945	COG1024	Enoyl-CoA hydratase
I6I22_RS07955	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I22_RS08005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I22_RS08010	COG0481	GTPase activity
I6I22_RS08025	COG0571	ribonuclease III activity
I6I22_RS08035	COG1381	Involved in DNA repair and RecF pathway recombination
I6I22_RS08040	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I22_RS08050	COG0583	DNA-binding transcription factor activity
I6I22_RS08060	COG0500	methyltransferase
I6I22_RS08065	COG2226	methyltransferase
I6I22_RS08075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I22_RS08090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I22_RS08105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I22_RS08130	COG1414	Transcriptional regulator
I6I22_RS08135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I22_RS08140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I22_RS08150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I22_RS08260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I22_RS08260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I22_RS08265	COG0489	protein tyrosine kinase activity
I6I22_RS08270	COG1278	Cold shock
I6I22_RS08275	COG0717	Belongs to the dCTP deaminase family
I6I22_RS08280	COG3005	denitrification pathway
I6I22_RS08290	COG0243	molybdopterin cofactor binding
I6I22_RS08300	COG4459	periplasmic nitrate reductase
I6I22_RS08305	COG2814	Major facilitator Superfamily
I6I22_RS08310	COG3091	SprT-like family
I6I22_RS08330	COG0037	tRNA processing
I6I22_RS08335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I22_RS08365	COG1294	oxidase, subunit
I6I22_RS08370	COG4890	Cyd operon protein YbgT
I6I22_RS08385	COG0791	NLP P60 protein
I6I22_RS08390	COG0791	NLP P60 protein
I6I22_RS08405	COG4206	TonB-dependent receptor
I6I22_RS08420	COG1797	cobyrinic acid a,c-diamide synthase activity
I6I22_RS08425	COG0778	Nitroreductase
I6I22_RS08435	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6I22_RS08445	COG1492	cobalamin metabolic process
I6I22_RS08455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I22_RS08465	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6I22_RS08475	COG0251	oxidation-reduction process
I6I22_RS08500	COG2067	long-chain fatty acid transport protein
I6I22_RS08515	COG3100	YcgL domain-containing protein
I6I22_RS08525	COG2983	Belongs to the UPF0260 family
I6I22_RS08540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I22_RS08545	COG0527	aspartate kinase activity
I6I22_RS08550	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6I22_RS08575	COG2239	Acts as a magnesium transporter
I6I22_RS08580	COG3630	sodium ion export across plasma membrane
I6I22_RS08585	COG0511	ligase activity, forming carbon-carbon bonds
I6I22_RS08585	COG5016	pyruvate
I6I22_RS08590	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6I22_RS08610	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6I22_RS08630	COG0784	Response regulator, receiver
I6I22_RS08630	COG0835	chemotaxis
I6I22_RS08635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I22_RS08640	COG1815	bacterial-type flagellum-dependent cell motility
I6I22_RS08660	COG4787	bacterial-type flagellum-dependent cell motility
I6I22_RS08665	COG4786	Flagellar basal body rod
I6I22_RS08670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6I22_RS08675	COG1706	bacterial-type flagellum-dependent cell motility
I6I22_RS08685	COG1256	bacterial-type flagellum assembly
I6I22_RS08695	COG1555	photosystem II stabilization
I6I22_RS08720	COG2199	diguanylate cyclase activity
I6I22_RS08720	COG2200	EAL domain
I6I22_RS08735	COG1362	aminopeptidase activity
I6I22_RS08740	COG0564	pseudouridine synthase activity
I6I22_RS08745	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I22_RS08750	COG2894	cell division
I6I22_RS08755	COG0850	regulation of cytokinetic process
I6I22_RS08760	COG1560	Kdo2-lipid A biosynthetic process
I6I22_RS08770	COG2853	Lipoprotein
I6I22_RS08785	COG3162	membrane
I6I22_RS08790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I22_RS08800	COG2223	nitrite transmembrane transporter activity
I6I22_RS08810	COG3089	Belongs to the UPF0270 family
I6I22_RS08820	COG1363	Peptidase, m42
I6I22_RS08825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I22_RS08825	COG0189	ligase activity
I6I22_RS08830	COG0367	asparagine synthase
I6I22_RS08840	COG4935	Belongs to the peptidase S8 family
I6I22_RS08840	COG1404	Belongs to the peptidase S8 family
I6I22_RS08850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I22_RS08860	COG4221	oxidoreductase activity
I6I22_RS08870	COG1201	RNA secondary structure unwinding
I6I22_RS08895	COG1187	pseudouridine synthase activity
I6I22_RS08905	COG2133	pyrroloquinoline quinone binding
I6I22_RS08910	COG4993	Dehydrogenase
I6I22_RS08915	COG2996	Protein conserved in bacteria
I6I22_RS08930	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I6I22_RS08970	COG3284	Transcriptional regulator
I6I22_RS08985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I22_RS08995	COG1696	Membrane protein involved in D-alanine export
I6I22_RS09010	COG0784	Response regulator, receiver
I6I22_RS09010	COG2198	Histidine kinase
I6I22_RS09010	COG5002	protein histidine kinase activity
I6I22_RS09030	COG3842	ATPase activity
I6I22_RS09050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I22_RS09060	COG1295	ribonuclease BN
I6I22_RS09085	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I22_RS09090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I22_RS09100	COG1546	Belongs to the CinA family
I6I22_RS09105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I22_RS09110	COG2137	regulation of response to DNA damage stimulus
I6I22_RS09120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6I22_RS09125	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6I22_RS09135	COG3148	PFAM DTW domain containing protein
I6I22_RS09140	COG0697	spore germination
I6I22_RS09150	COG0583	DNA-binding transcription factor activity
I6I22_RS09160	COG3012	SEC-C Motif Domain Protein
I6I22_RS09180	COG1199	ATP-dependent helicase activity
I6I22_RS09185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I22_RS09195	COG0259	pyridoxamine-phosphate oxidase activity
I6I22_RS09205	COG3133	Outer membrane lipoprotein
I6I22_RS09210	COG2111	Na H antiporter
I6I22_RS09210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I22_RS09215	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I22_RS09220	COG0651	ATP synthesis coupled electron transport
I6I22_RS09225	COG1863	multisubunit Na H antiporter MnhE subunit
I6I22_RS09230	COG2212	antiporter activity
I6I22_RS09235	COG1320	monovalent cation:proton antiporter activity
I6I22_RS09240	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I22_RS09245	COG0024	Methionine aminopeptidase
I6I22_RS09250	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I22_RS09255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I22_RS09260	COG0528	UMP kinase activity
I6I22_RS09265	COG0233	cytoplasmic translational termination
I6I22_RS09270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I22_RS09280	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I22_RS09290	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I22_RS09305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I22_RS09310	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I22_RS09315	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I22_RS09320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I22_RS09330	COG0825	malonyl-CoA metabolic process
I6I22_RS09335	COG0037	tRNA processing
I6I22_RS09340	COG0504	CTP synthase activity
I6I22_RS09345	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I22_RS09350	COG0148	phosphopyruvate hydratase activity
I6I22_RS09360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I22_RS09375	COG0583	DNA-binding transcription factor activity
I6I22_RS09380	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I22_RS09385	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I22_RS09390	COG1902	pentaerythritol trinitrate reductase activity
I6I22_RS09400	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I22_RS09405	COG0585	pseudouridine synthase activity
I6I22_RS09410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I22_RS09415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I22_RS09460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I22_RS09470	COG0589	response to stress
I6I22_RS09480	COG0217	transcriptional regulatory protein
I6I22_RS09495	COG2258	MOSC domain
I6I22_RS09510	COG0004	ammonium transporteR
I6I22_RS09530	COG0483	inositol monophosphate 1-phosphatase activity
I6I22_RS09560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I22_RS09585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I22_RS09605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I22_RS09620	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS09625	COG2814	Major facilitator Superfamily
I6I22_RS09635	COG0826	peptidase U32
I6I22_RS09640	COG3459	Glycosyltransferase 36 associated
I6I22_RS09695	COG1733	regulation of RNA biosynthetic process
I6I22_RS09700	COG0583	DNA-binding transcription factor activity
I6I22_RS09705	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I22_RS09730	COG2226	methyltransferase
I6I22_RS09740	COG2807	transmembrane transport
I6I22_RS09745	COG1846	Transcriptional regulator
I6I22_RS09760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I22_RS09765	COG0583	DNA-binding transcription factor activity
I6I22_RS09785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I22_RS09790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I22_RS09790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I22_RS09795	COG0745	RESPONSE REGULATOR receiver
I6I22_RS09800	COG2205	protein histidine kinase activity
I6I22_RS09815	COG2937	Belongs to the GPAT DAPAT family
I6I22_RS09820	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6I22_RS09850	COG1131	(ABC) transporter
I6I22_RS09865	COG1278	Cold shock
I6I22_RS09875	COG2226	methyltransferase
I6I22_RS09880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I22_RS09885	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I22_RS09925	COG0513	Belongs to the DEAD box helicase family
I6I22_RS09940	COG0583	DNA-binding transcription factor activity
I6I22_RS09960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I22_RS09960	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I22_RS09965	COG5002	protein histidine kinase activity
I6I22_RS09965	COG2205	protein histidine kinase activity
I6I22_RS09965	COG0784	Response regulator, receiver
I6I22_RS09970	COG2860	membrane
I6I22_RS09985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I22_RS09990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I22_RS09995	COG3956	TIGRFAM MazG family protein
I6I22_RS10020	COG1201	RNA secondary structure unwinding
I6I22_RS10030	COG1793	dna ligase
I6I22_RS10045	COG0668	transmembrane transport
I6I22_RS10080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I22_RS10090	COG2988	succinylglutamate desuccinylase activity
I6I22_RS10095	COG1131	(ABC) transporter
I6I22_RS10100	COG0842	Transport permease protein
I6I22_RS10105	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I22_RS10105	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I22_RS10115	COG2853	Lipoprotein
I6I22_RS10125	COG0745	RESPONSE REGULATOR receiver
I6I22_RS10135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I22_RS10170	COG2814	Major facilitator Superfamily
I6I22_RS10175	COG4948	Mandelate Racemase Muconate Lactonizing
I6I22_RS10180	COG4829	muconolactone delta-isomerase
I6I22_RS10185	COG3485	protocatechuate 3,4-dioxygenase
I6I22_RS10190	COG3135	benzoate transporter
I6I22_RS10225	COG0114	fumarate hydratase activity
I6I22_RS10235	COG0271	Belongs to the BolA IbaG family
I6I22_RS10240	COG1054	Belongs to the UPF0176 family
I6I22_RS10255	COG0840	transmembrane signaling receptor activity
I6I22_RS10280	COG0583	DNA-binding transcription factor activity
I6I22_RS10285	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6I22_RS10290	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS10300	COG2079	MmgE PrpD family protein
I6I22_RS10305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I22_RS10310	COG2301	Belongs to the HpcH HpaI aldolase family
I6I22_RS10330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I22_RS10335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I22_RS10340	COG0583	DNA-binding transcription factor activity
I6I22_RS10350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I22_RS10360	COG1770	oligopeptidase
I6I22_RS10365	COG1024	Enoyl-CoA hydratase
I6I22_RS10365	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I22_RS10370	COG0183	Belongs to the thiolase family
I6I22_RS10405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I22_RS10435	COG0653	protein targeting
I6I22_RS10455	COG0133	tryptophan synthase activity
I6I22_RS10460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I22_RS10465	COG1012	belongs to the aldehyde dehydrogenase family
I6I22_RS10470	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I22_RS10475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I22_RS10505	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6I22_RS10555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I22_RS10705	COG3179	chitinase
I6I22_RS10735	COG2135	peptidase activity
I6I22_RS10745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I22_RS10795	COG4964	Belongs to the GSP D family
I6I22_RS10850	COG1216	Glycosyl transferase, family 2
I6I22_RS10865	COG0297	glycogen (starch) synthase activity
I6I22_RS10895	COG0250	Participates in transcription elongation, termination and antitermination
I6I22_RS10955	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS10970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I22_RS10975	COG0066	3-isopropylmalate dehydratase activity
I6I22_RS10980	COG0473	3-isopropylmalate dehydrogenase activity
I6I22_RS11005	COG0135	phosphoribosylanthranilate isomerase activity
I6I22_RS11010	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I22_RS11015	COG0285	dihydrofolate synthase activity
I6I22_RS11020	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I22_RS11025	COG1286	toxin biosynthetic process
I6I22_RS11075	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I22_RS11100	COG1271	oxidase subunit
I6I22_RS11105	COG1294	oxidase, subunit
I6I22_RS11125	COG1902	pentaerythritol trinitrate reductase activity
I6I22_RS11125	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I22_RS11140	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I22_RS11155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I22_RS11165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I22_RS11170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I22_RS11185	COG0573	inorganic phosphate transmembrane transporter activity
I6I22_RS11205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I22_RS11215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I22_RS11245	COG2010	Cytochrome c
I6I22_RS11260	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I22_RS11265	COG2010	Cytochrome c
I6I22_RS11275	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I22_RS11285	COG0840	transmembrane signaling receptor activity
I6I22_RS11295	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6I22_RS11315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I22_RS11320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I22_RS11320	COG2010	Cytochrome c
I6I22_RS11335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I22_RS11340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I22_RS11345	COG1196	nuclear chromosome segregation
I6I22_RS11350	COG3115	cell septum assembly
I6I22_RS11355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I22_RS11360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I22_RS11380	COG0028	Belongs to the TPP enzyme family
I6I22_RS11385	COG0546	phosphoglycolate phosphatase activity
I6I22_RS11420	COG1215	transferase activity, transferring glycosyl groups
I6I22_RS11425	COG0438	transferase activity, transferring glycosyl groups
I6I22_RS11425	COG1216	Glycosyl transferase, family 2
I6I22_RS11430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6I22_RS11440	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6I22_RS11470	COG2009	succinate dehydrogenase
I6I22_RS11475	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I22_RS11480	COG1053	succinate dehydrogenase
I6I22_RS11485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I22_RS11505	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I22_RS11565	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6I22_RS11575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I22_RS11580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I22_RS11615	COG0628	permease
I6I22_RS11625	COG0709	Synthesizes selenophosphate from selenide and ATP
I6I22_RS11630	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6I22_RS11640	COG0714	Associated with various cellular activities
I6I22_RS11665	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6I22_RS11685	COG1238	metal cluster binding
I6I22_RS11700	COG0183	Belongs to the thiolase family
I6I22_RS11705	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS11715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I22_RS11725	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS11730	COG1024	Enoyl-CoA hydratase
I6I22_RS11760	COG0058	SHG alpha-glucan phosphorylase activity
I6I22_RS11775	COG4991	sh3 domain protein
I6I22_RS11780	COG1253	flavin adenine dinucleotide binding
I6I22_RS11790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I22_RS11810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I22_RS11825	COG3447	MASE1 domain protein
I6I22_RS11825	COG5001	Diguanylate cyclase
I6I22_RS11825	COG5002	protein histidine kinase activity
I6I22_RS11860	COG4191	Histidine kinase
I6I22_RS11860	COG0784	Response regulator, receiver
I6I22_RS11865	COG0210	DNA helicase
I6I22_RS11870	COG0515	serine threonine protein kinase
I6I22_RS11880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I22_RS11880	COG2146	nitrite reductase [NAD(P)H] activity
I6I22_RS11885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I22_RS11885	COG2146	nitrite reductase [NAD(P)H] activity
I6I22_RS11895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I22_RS11905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I22_RS11920	COG4221	oxidoreductase activity
I6I22_RS11930	COG0415	Belongs to the DNA photolyase family
I6I22_RS11935	COG0789	Transcriptional regulator
I6I22_RS11940	COG3272	Protein of unknown function (DUF1722)
I6I22_RS11945	COG1090	epimerase
I6I22_RS11950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I22_RS11955	COG5001	Diguanylate cyclase
I6I22_RS11960	COG1366	Belongs to the anti-sigma-factor antagonist family
I6I22_RS11980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I22_RS11985	COG0302	gtp cyclohydrolase
I6I22_RS12000	COG0789	Transcriptional regulator
I6I22_RS12005	COG1025	Belongs to the peptidase M16 family
I6I22_RS12020	COG0784	Response regulator, receiver
I6I22_RS12020	COG2205	protein histidine kinase activity
I6I22_RS12025	COG0435	Glutathione S-transferase
I6I22_RS12030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I22_RS12035	COG2920	part of a sulfur-relay system
I6I22_RS12085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I22_RS12090	COG1116	anion transmembrane transporter activity
I6I22_RS12095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I22_RS12110	COG1335	isochorismatase
I6I22_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS12140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I22_RS12150	COG0668	transmembrane transport
I6I22_RS12160	COG4770	biotin carboxylase activity
I6I22_RS12170	COG3665	Urea carboxylase-associated protein
I6I22_RS12175	COG3842	ATPase activity
I6I22_RS12195	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I22_RS12200	COG5380	lipid catabolic process
I6I22_RS12215	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I22_RS12220	COG4181	ATPase activity
I6I22_RS12250	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I22_RS12255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I22_RS12270	COG0560	Phosphoserine phosphatase
I6I22_RS12295	COG1802	Transcriptional regulator
I6I22_RS12305	COG0372	Belongs to the citrate synthase family
I6I22_RS12320	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I22_RS12330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I22_RS12345	COG0668	transmembrane transport
I6I22_RS12380	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I22_RS12385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I22_RS12390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I22_RS12395	COG0215	cysteine-tRNA ligase activity
I6I22_RS12400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I22_RS12425	COG2186	Transcriptional regulator
I6I22_RS12450	COG1764	response to oxidative stress
I6I22_RS12455	COG1846	Transcriptional regulator
I6I22_RS12465	COG2010	Cytochrome c
I6I22_RS12470	COG3256	nitric oxide reductase
I6I22_RS12475	COG0714	Associated with various cellular activities
I6I22_RS12485	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I22_RS12495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I22_RS12500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I22_RS12510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I22_RS12515	COG0167	dihydroorotate dehydrogenase activity
I6I22_RS12520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I22_RS12560	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I22_RS12565	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I6I22_RS12575	COG0535	radical SAM domain protein
I6I22_RS12590	COG0784	Response regulator, receiver
I6I22_RS12590	COG2205	protein histidine kinase activity
I6I22_RS12605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I22_RS12610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I22_RS12625	COG0322	excinuclease ABC activity
I6I22_RS12665	COG0798	PFAM Bile acid sodium symporter
I6I22_RS12670	COG2072	flavoprotein involved in K transport
I6I22_RS12675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I22_RS12680	COG0640	Transcriptional regulator
I6I22_RS12685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I22_RS12690	COG0431	NADPH-dependent FMN reductase
I6I22_RS12700	COG1742	UPF0060 membrane protein
I6I22_RS12705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I22_RS12730	COG5642	Protein of unknown function (DUF2384)
I6I22_RS12755	COG0840	transmembrane signaling receptor activity
I6I22_RS12825	COG0583	DNA-binding transcription factor activity
I6I22_RS12865	COG3685	Protein conserved in bacteria
I6I22_RS12870	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6I22_RS12870	COG3264	Mechanosensitive ion channel
I6I22_RS12875	COG1058	Belongs to the CinA family
I6I22_RS12875	COG1546	Belongs to the CinA family
I6I22_RS12880	COG0297	glycogen (starch) synthase activity
I6I22_RS12885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I22_RS12910	COG0739	heme binding
I6I22_RS12920	COG3384	dioxygenase
I6I22_RS12925	COG0583	DNA-binding transcription factor activity
I6I22_RS12935	COG3568	Endonuclease Exonuclease Phosphatase
I6I22_RS12940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I22_RS12945	COG0392	lysyltransferase activity
I6I22_RS12950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I22_RS12955	COG0366	Alpha amylase catalytic
I6I22_RS12980	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS12985	COG0604	alcohol dehydrogenase
I6I22_RS12985	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS12985	COG3321	synthase
I6I22_RS13035	COG0728	peptidoglycan biosynthetic process
I6I22_RS13050	COG1115	amino acid carrier protein
I6I22_RS13055	COG2911	Protein conserved in bacteria
I6I22_RS13060	COG0729	surface antigen
I6I22_RS13075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I22_RS13095	COG1175	transmembrane transport
I6I22_RS13115	COG1070	Carbohydrate kinase
I6I22_RS13130	COG1609	Transcriptional regulator
I6I22_RS13135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I22_RS13140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I22_RS13145	COG3265	gluconokinase activity
I6I22_RS13150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I22_RS13155	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I22_RS13185	COG0488	(ABC) transporter
I6I22_RS13190	COG2267	carboxylic ester hydrolase activity
I6I22_RS13195	COG1968	undecaprenyl-diphosphatase activity
I6I22_RS13200	COG0840	transmembrane signaling receptor activity
I6I22_RS13215	COG2323	membrane
I6I22_RS13230	COG3706	GGDEF domain
I6I22_RS13235	COG2197	response regulator
I6I22_RS13240	COG0316	Belongs to the HesB IscA family
I6I22_RS13240	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I22_RS13285	COG2223	nitrite transmembrane transporter activity
I6I22_RS13290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I22_RS13295	COG0515	serine threonine protein kinase
I6I22_RS13305	COG0071	Belongs to the small heat shock protein (HSP20) family
I6I22_RS13325	COG0604	alcohol dehydrogenase
I6I22_RS13330	COG0616	signal peptide processing
I6I22_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS13360	COG0730	response to heat
I6I22_RS13365	COG2816	NAD+ diphosphatase activity
I6I22_RS13375	COG1024	Enoyl-CoA hydratase
I6I22_RS13385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I22_RS13390	COG0328	RNA-DNA hybrid ribonuclease activity
I6I22_RS13400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I22_RS13405	COG0741	lytic transglycosylase activity
I6I22_RS13405	COG1388	LysM domain
I6I22_RS13415	COG4166	transmembrane transport
I6I22_RS13425	COG4174	ABC transporter (Permease)
I6I22_RS13430	COG4239	(ABC) transporter, permease
I6I22_RS13435	COG4172	Belongs to the ABC transporter superfamily
I6I22_RS13445	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS13465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I22_RS13520	COG3851	Histidine kinase
I6I22_RS13530	COG0840	transmembrane signaling receptor activity
I6I22_RS13550	COG1131	(ABC) transporter
I6I22_RS13570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I22_RS13570	COG1648	precorrin-2 dehydrogenase activity
I6I22_RS13575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I22_RS13580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I22_RS13585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I22_RS13590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I22_RS13600	COG0492	ferredoxin-NADP+ reductase activity
I6I22_RS13605	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I22_RS13610	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6I22_RS13615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I22_RS13620	COG0542	response to heat
I6I22_RS13625	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I22_RS13650	COG0482	sulfurtransferase activity
I6I22_RS13655	COG2915	High frequency lysogenization protein hflD homolog
I6I22_RS13665	COG2850	peptidyl-arginine hydroxylation
I6I22_RS13670	COG2153	protein acetylation
I6I22_RS13695	COG0628	permease
I6I22_RS13700	COG2056	Na+-H+ antiporter family
I6I22_RS13705	COG0720	synthase
I6I22_RS13735	COG0402	S-adenosylhomocysteine deaminase activity
I6I22_RS13740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I22_RS13745	COG0546	phosphoglycolate phosphatase activity
I6I22_RS13750	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS13760	COG0800	Aldolase
I6I22_RS13785	COG2840	Smr protein MutS2
I6I22_RS13790	COG0302	gtp cyclohydrolase
I6I22_RS13795	COG0625	glutathione transferase activity
I6I22_RS13800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I22_RS13815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I22_RS13820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I22_RS13830	COG0077	Prephenate dehydratase
I6I22_RS13830	COG1605	Chorismate mutase
I6I22_RS13835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I22_RS13845	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6I22_RS13860	COG0587	DNA-directed DNA polymerase activity
I6I22_RS13880	COG0776	regulation of translation
I6I22_RS13885	COG0072	phenylalanine-tRNA ligase activity
I6I22_RS13890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I22_RS13895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I22_RS13900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I22_RS13905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I22_RS13910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I22_RS13920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I22_RS13995	COG3171	Protein conserved in bacteria
I6I22_RS14000	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I22_RS14005	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I22_RS14005	COG0116	Belongs to the methyltransferase superfamily
I6I22_RS14010	COG3130	regulation of translation
I6I22_RS14015	COG0167	dihydroorotate dehydrogenase activity
I6I22_RS14035	COG0714	Associated with various cellular activities
I6I22_RS14055	COG2304	oxidoreductase activity
I6I22_RS14065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I22_RS14070	COG2197	response regulator
I6I22_RS14090	COG2223	nitrite transmembrane transporter activity
I6I22_RS14095	COG0515	serine threonine protein kinase
I6I22_RS14095	COG2815	serine threonine protein kinase
I6I22_RS14105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I22_RS14110	COG2146	nitrite reductase [NAD(P)H] activity
I6I22_RS14115	COG0243	molybdopterin cofactor binding
I6I22_RS14135	COG0308	aminopeptidase N
I6I22_RS14155	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I22_RS14160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I22_RS14180	COG0583	DNA-binding transcription factor activity
I6I22_RS14190	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I22_RS14215	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6I22_RS14220	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6I22_RS14225	COG0235	Class ii aldolase
I6I22_RS14235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I22_RS14255	COG3842	ATPase activity
I6I22_RS14260	COG0395	ABC-type sugar transport system, permease component
I6I22_RS14265	COG1175	transmembrane transport
I6I22_RS14270	COG1653	transport
I6I22_RS14295	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I22_RS14300	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I22_RS14305	COG0180	Tryptophanyl-tRNA synthetase
I6I22_RS14310	COG0009	L-threonylcarbamoyladenylate synthase
I6I22_RS14315	COG0613	PHP domain protein
I6I22_RS14320	COG2350	Protein conserved in bacteria
I6I22_RS14330	COG0745	RESPONSE REGULATOR receiver
I6I22_RS14345	COG0778	Nitroreductase
I6I22_RS14350	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6I22_RS14355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I22_RS14360	COG2354	Protein conserved in bacteria
I6I22_RS14395	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I22_RS14415	COG2832	Protein of unknown function (DUF454)
I6I22_RS14425	COG3300	MHYT domain
I6I22_RS14425	COG5001	Diguanylate cyclase
I6I22_RS14450	COG2274	protein secretion by the type I secretion system
I6I22_RS14455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I22_RS14470	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6I22_RS14480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I22_RS14490	COG0542	response to heat
I6I22_RS14510	COG0121	glutamine amidotransferase
I6I22_RS14520	COG0589	response to stress
I6I22_RS14530	COG0488	(ABC) transporter
I6I22_RS14535	COG0741	lytic transglycosylase activity
I6I22_RS14540	COG0633	Ferredoxin
I6I22_RS14540	COG3217	Mosc domain protein beta barrel domain protein
I6I22_RS14555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I22_RS14560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I22_RS14565	COG0489	protein tyrosine kinase activity
I6I22_RS14565	COG3206	protein involved in exopolysaccharide biosynthesis
I6I22_RS14570	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I6I22_RS14610	COG0183	Belongs to the thiolase family
I6I22_RS14620	COG2977	Belongs to the P-Pant transferase superfamily
I6I22_RS14650	COG1051	belongs to the nudix hydrolase family
I6I22_RS14655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I22_RS14685	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6I22_RS14700	COG0776	regulation of translation
I6I22_RS14710	COG0840	transmembrane signaling receptor activity
I6I22_RS14720	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6I22_RS14725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I22_RS14740	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I6I22_RS14765	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I22_RS14770	COG1136	(ABC) transporter
I6I22_RS14790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I22_RS14845	COG0386	Belongs to the glutathione peroxidase family
I6I22_RS14850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I22_RS14855	COG0436	Aminotransferase
I6I22_RS14865	COG0501	Belongs to the peptidase M48B family
I6I22_RS14875	COG0500	methyltransferase
I6I22_RS14920	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I22_RS14950	COG2257	FlhB HrpN YscU SpaS Family
I6I22_RS14965	COG0835	chemotaxis
I6I22_RS14975	COG1192	Involved in chromosome partitioning
I6I22_RS14980	COG1360	Flagellar Motor Protein
I6I22_RS14985	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6I22_RS14995	COG0643	Histidine kinase
I6I22_RS14995	COG0784	Response regulator, receiver
I6I22_RS14995	COG2198	Histidine kinase
I6I22_RS15000	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6I22_RS15030	COG2032	superoxide dismutase activity
I6I22_RS15045	COG1987	bacterial-type flagellum assembly
I6I22_RS15085	COG0745	RESPONSE REGULATOR receiver
I6I22_RS15120	COG1677	Flagellar hook-basal body complex protein FliE
I6I22_RS15125	COG3135	benzoate transporter
I6I22_RS15135	COG2130	NADP-dependent
I6I22_RS15150	COG3300	MHYT domain
I6I22_RS15150	COG5001	Diguanylate cyclase
I6I22_RS15160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I22_RS15175	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I22_RS15220	COG1113	amino acid transport
I6I22_RS15225	COG0084	hydrolase, TatD family'
I6I22_RS15240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I22_RS15245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I22_RS15255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I22_RS15260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I22_RS15275	COG0416	fatty acid biosynthetic process
I6I22_RS15280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I22_RS15295	COG0616	signal peptide processing
I6I22_RS15295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I22_RS15300	COG0546	phosphoglycolate phosphatase activity
I6I22_RS15310	COG1530	ribonuclease E activity
I6I22_RS15315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I22_RS15320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I22_RS15325	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I22_RS15330	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I22_RS15335	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I22_RS15345	COG0811	peptide transport
I6I22_RS15350	COG0658	competence protein
I6I22_RS15350	COG2333	competence protein COMEC
I6I22_RS15365	COG1136	(ABC) transporter
I6I22_RS15370	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I22_RS15385	COG0584	glycerophosphoryl diester phosphodiesterase
I6I22_RS15390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I22_RS15400	COG1477	protein flavinylation
I6I22_RS15410	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I22_RS15425	COG1805	sodium ion transport
I6I22_RS15440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I22_RS15450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I22_RS15465	COG4989	oxidoreductase activity
I6I22_RS15475	COG0800	Aldolase
I6I22_RS15490	COG1737	Transcriptional regulator
I6I22_RS15510	COG2814	Major facilitator Superfamily
I6I22_RS15545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I22_RS15545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I22_RS15560	COG3154	lipid carrier protein
I6I22_RS15565	COG0826	peptidase U32
I6I22_RS15570	COG0826	peptidase U32
I6I22_RS15580	COG3604	Transcriptional regulator
I6I22_RS15610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I22_RS15625	COG0642	Histidine kinase
I6I22_RS15640	COG2217	Heavy metal translocating P-type atpase
I6I22_RS15650	COG2132	Multicopper oxidase
I6I22_RS15705	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I22_RS15715	COG1346	cytolysis
I6I22_RS15720	COG1380	Effector of murein hydrolase LrgA
I6I22_RS15725	COG0348	domain, Protein
I6I22_RS15730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I22_RS15750	COG1309	transcriptional regulator
I6I22_RS15760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I22_RS15770	COG0742	ribosomal rna small subunit methyltransferase
I6I22_RS15795	COG0563	adenylate kinase activity
I6I22_RS15800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I22_RS15840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I22_RS15855	COG1902	pentaerythritol trinitrate reductase activity
I6I22_RS15860	COG3383	formate dehydrogenase (NAD+) activity
I6I22_RS15865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I22_RS15880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I22_RS15885	COG1984	allophanate hydrolase subunit 2
I6I22_RS15890	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I22_RS15910	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I22_RS15925	COG2974	May be involved in recombination
I6I22_RS15930	COG2814	Major facilitator Superfamily
I6I22_RS15950	COG2205	protein histidine kinase activity
I6I22_RS15955	COG3174	membrane
I6I22_RS15990	COG0417	DNA replication proofreading
I6I22_RS16000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I22_RS16010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I22_RS16015	COG2716	regulation of RNA biosynthetic process
I6I22_RS16020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I22_RS16030	COG0425	Belongs to the sulfur carrier protein TusA family
I6I22_RS16040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I22_RS16045	COG0427	acetyl-CoA hydrolase
I6I22_RS16055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I22_RS16060	COG0602	queuosine metabolic process
I6I22_RS16065	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6I22_RS16070	COG2885	chlorophyll binding
I6I22_RS16075	COG0823	Involved in the tonB-independent uptake of proteins
I6I22_RS16095	COG0824	Thioesterase
I6I22_RS16100	COG2255	four-way junction helicase activity
I6I22_RS16105	COG0632	four-way junction helicase activity
I6I22_RS16110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I22_RS16120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I22_RS16125	COG0783	Belongs to the Dps family
I6I22_RS16135	COG2900	Belongs to the SlyX family
I6I22_RS16150	COG0442	prolyl-tRNA aminoacylation
I6I22_RS16180	COG1295	ribonuclease BN
I6I22_RS16185	COG1393	Belongs to the ArsC family
I6I22_RS16200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I22_RS16205	COG0628	permease
I6I22_RS16215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I22_RS16220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I22_RS16235	COG0436	Aminotransferase
I6I22_RS16255	COG1393	Belongs to the ArsC family
I6I22_RS16260	COG2171	N-acyltransferase activity
I6I22_RS16265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I22_RS16280	COG3258	Cytochrome c
I6I22_RS16285	COG2863	cytochrome
I6I22_RS16295	COG3530	Putative quorum-sensing-regulated virulence factor
I6I22_RS16305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I22_RS16315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I22_RS16325	COG0583	DNA-binding transcription factor activity
I6I22_RS16330	COG4221	oxidoreductase activity
I6I22_RS16340	COG1280	lysine exporter protein (LysE YggA)
I6I22_RS16360	COG1462	curli production assembly transport component CsgG
I6I22_RS16380	COG1309	transcriptional regulator
I6I22_RS16390	COG4067	protein conserved in archaea
I6I22_RS16390	COG0189	ligase activity
I6I22_RS16405	COG4771	TonB-dependent receptor
I6I22_RS16410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I22_RS16415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I22_RS16420	COG1120	ATPase activity
I6I22_RS16435	COG3321	synthase
I6I22_RS16435	COG0604	alcohol dehydrogenase
I6I22_RS16445	COG3284	Transcriptional regulator
I6I22_RS16460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I22_RS16465	COG1063	alcohol dehydrogenase
I6I22_RS16470	COG0022	dehydrogenase e1 component
I6I22_RS16475	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I22_RS16480	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I22_RS16485	COG0095	Lipoate-protein ligase
I6I22_RS16510	COG0583	DNA-binding transcription factor activity
I6I22_RS16565	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I6I22_RS16585	COG1522	sequence-specific DNA binding
I6I22_RS16605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I22_RS16615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I22_RS16625	COG4221	oxidoreductase activity
I6I22_RS16635	COG2207	Transcriptional regulator
I6I22_RS16640	COG3845	ABC transporter
I6I22_RS16645	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I22_RS16650	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I22_RS16665	COG1301	dicarboxylic acid transport
I6I22_RS16675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I22_RS16680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I22_RS16690	COG0471	metal ion transport
I6I22_RS16690	COG0490	domain, Protein
I6I22_RS16720	COG2814	Major facilitator Superfamily
I6I22_RS16730	COG0596	Alpha beta hydrolase
I6I22_RS16730	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I22_RS16755	COG1279	arginine transmembrane transporter activity
I6I22_RS16775	COG2733	membrane
I6I22_RS16780	COG1116	anion transmembrane transporter activity
I6I22_RS16795	COG0537	adenosine 5'-monophosphoramidase activity
I6I22_RS16815	COG3795	YCII-related domain
I6I22_RS16830	COG1234	tRNA 3'-trailer cleavage
I6I22_RS16850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I22_RS16855	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6I22_RS16860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I22_RS16865	COG2205	protein histidine kinase activity
I6I22_RS16870	COG0631	protein serine/threonine phosphatase activity
I6I22_RS16875	COG0515	serine threonine protein kinase
I6I22_RS16875	COG2815	serine threonine protein kinase
I6I22_RS16890	COG1643	Atp-dependent helicase
I6I22_RS16910	COG0318	PFAM AMP-dependent synthetase and ligase
I6I22_RS16915	COG0318	PFAM AMP-dependent synthetase and ligase
I6I22_RS16920	COG2030	dehydratase
I6I22_RS16945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I22_RS16955	COG0443	Heat shock 70 kDa protein
I6I22_RS16960	COG2271	Major facilitator Superfamily
I6I22_RS16965	COG3622	Belongs to the hyi family
I6I22_RS16970	COG2084	Dehydrogenase
I6I22_RS16975	COG1968	undecaprenyl-diphosphatase activity
I6I22_RS16985	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6I22_RS16995	COG3639	organic phosphonate transmembrane transporter activity
I6I22_RS17000	COG3639	organic phosphonate transmembrane transporter activity
I6I22_RS17080	COG2165	general secretion pathway protein
I6I22_RS17085	COG2165	general secretion pathway protein
I6I22_RS17095	COG2165	general secretion pathway protein
I6I22_RS17100	COG1459	type II secretion system
I6I22_RS17115	COG3409	Peptidoglycan-binding domain 1 protein
I6I22_RS17115	COG3267	Type II secretory pathway component ExeA
I6I22_RS17145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I22_RS17180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I22_RS17185	COG0556	nucleotide-excision repair
I6I22_RS17205	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I22_RS17215	COG3842	ATPase activity
I6I22_RS17220	COG0590	tRNA wobble adenosine to inosine editing
I6I22_RS17230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I22_RS17230	COG0519	Catalyzes the synthesis of GMP from XMP
I6I22_RS17245	COG1570	exodeoxyribonuclease VII activity
I6I22_RS17250	COG0739	heme binding
I6I22_RS17260	COG0668	transmembrane transport
I6I22_RS17275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I22_RS17280	COG1064	alcohol dehydrogenase
I6I22_RS17290	COG2356	endonuclease I
I6I22_RS17295	COG3647	Membrane
I6I22_RS17310	COG0436	Aminotransferase
I6I22_RS17315	COG1045	serine acetyltransferase
I6I22_RS17320	COG1160	GTP binding
I6I22_RS17330	COG2976	Protein conserved in bacteria
I6I22_RS17335	COG0124	histidyl-tRNA synthetase
I6I22_RS17340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I22_RS17355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I22_RS17360	COG0105	UTP biosynthetic process
I6I22_RS17375	COG0443	Heat shock 70 kDa protein
I6I22_RS17380	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I22_RS17385	COG0316	Belongs to the HesB IscA family
I6I22_RS17395	COG1104	cysteine desulfurase activity
I6I22_RS17420	COG3134	Outer membrane lipoprotein
I6I22_RS17435	COG1862	Preprotein translocase
I6I22_RS17445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I22_RS17455	COG1278	Cold shock
I6I22_RS17465	COG0795	lipopolysaccharide-transporting ATPase activity
I6I22_RS17470	COG0795	lipopolysaccharide-transporting ATPase activity
I6I22_RS17475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I22_RS17505	COG0490	domain, Protein
I6I22_RS17505	COG0471	metal ion transport
I6I22_RS17510	COG0477	Major facilitator Superfamily
I6I22_RS17515	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6I22_RS17535	COG3081	Nucleoid-associated protein
I6I22_RS17540	COG2326	polyphosphate kinase activity
I6I22_RS17560	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I22_RS17565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I22_RS17605	COG0402	S-adenosylhomocysteine deaminase activity
I6I22_RS17610	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I22_RS17620	COG1121	(ABC) transporter
I6I22_RS17625	COG1802	Transcriptional regulator
I6I22_RS17630	COG2252	PERMEase
I6I22_RS17655	COG4266	Belongs to the allantoicase family
I6I22_RS17660	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6I22_RS17670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I22_RS17670	COG4651	solute:proton antiporter activity
I6I22_RS17675	COG2233	PERMEase
I6I22_RS17695	COG5001	Diguanylate cyclase
I6I22_RS17695	COG3300	MHYT domain
I6I22_RS17720	COG2351	hydroxyisourate hydrolase activity
I6I22_RS17725	COG0583	DNA-binding transcription factor activity
I6I22_RS17730	COG3960	tartronate-semialdehyde synthase activity
I6I22_RS17735	COG3622	Belongs to the hyi family
I6I22_RS17740	COG2084	Dehydrogenase
I6I22_RS17750	COG0469	pyruvate kinase activity
I6I22_RS17760	COG1017	nitric oxide dioxygenase activity
I6I22_RS17760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I22_RS17775	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I22_RS17780	COG3706	GGDEF domain
I6I22_RS17800	COG0583	DNA-binding transcription factor activity
I6I22_RS17805	COG1279	arginine transmembrane transporter activity
I6I22_RS17830	COG1704	LemA family
I6I22_RS17860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I22_RS17865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I22_RS17875	COG0459	protein refolding
I6I22_RS17880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I22_RS17885	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6I22_RS17895	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS17905	COG3695	enzyme binding
I6I22_RS17915	COG0668	transmembrane transport
I6I22_RS17920	COG1666	GTP binding
I6I22_RS17925	COG0745	RESPONSE REGULATOR receiver
I6I22_RS17935	COG4191	Histidine kinase
I6I22_RS17940	COG2096	Adenosyltransferase
I6I22_RS17970	COG0494	nUDIX hydrolase
I6I22_RS17980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I22_RS17985	COG0653	protein targeting
I6I22_RS18025	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6I22_RS18030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I22_RS18050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I22_RS18055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I22_RS18065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I22_RS18070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I22_RS18080	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6I22_RS18085	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I22_RS18105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I22_RS18135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I22_RS18145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I22_RS18160	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I22_RS18190	COG0318	PFAM AMP-dependent synthetase and ligase
I6I22_RS18195	COG4294	response to UV
I6I22_RS18200	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS18205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I22_RS18210	COG1024	Enoyl-CoA hydratase
I6I22_RS18240	COG0789	Transcriptional regulator
I6I22_RS18245	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I22_RS18255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I22_RS18270	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I22_RS18350	COG4128	Pfam Zonular occludens toxin
I6I22_RS18360	COG4974	Belongs to the 'phage' integrase family
I6I22_RS18370	COG1487	ribonuclease activity
I6I22_RS18380	COG0697	spore germination
I6I22_RS18385	COG0288	reversible hydration of carbon dioxide
I6I22_RS18390	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I22_RS18395	COG1877	trehalose-phosphatase activity
I6I22_RS18405	COG0456	acetyltransferase
I6I22_RS18415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I22_RS18425	COG0019	diaminopimelate decarboxylase activity
I6I22_RS18445	COG3008	intermembrane lipid transfer
I6I22_RS18450	COG2995	paraquat-inducible protein a
I6I22_RS18455	COG2995	paraquat-inducible protein a
I6I22_RS18485	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I22_RS18495	COG1183	phosphatidylcholine synthase activity
I6I22_RS18500	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I22_RS18510	COG0028	Belongs to the TPP enzyme family
I6I22_RS18530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I22_RS18565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I22_RS18580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I22_RS18595	COG2264	protein methyltransferase activity
I6I22_RS18615	COG0138	bifunctional purine biosynthesis protein purh
I6I22_RS18625	COG0784	Response regulator, receiver
I6I22_RS18625	COG2205	protein histidine kinase activity
I6I22_RS18625	COG5002	protein histidine kinase activity
I6I22_RS18640	COG0679	Auxin Efflux Carrier
I6I22_RS18655	COG0436	Aminotransferase
I6I22_RS18660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I22_RS18665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I22_RS18675	COG4191	Histidine kinase
I6I22_RS18695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I22_RS18700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I22_RS18705	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I22_RS18710	COG0166	Belongs to the GPI family
I6I22_RS18720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I22_RS18745	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I22_RS18750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I22_RS18755	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I22_RS18760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I22_RS18765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I22_RS18770	COG0195	Participates in both transcription termination and antitermination
I6I22_RS18770	COG2251	uridine kinase activity
I6I22_RS18775	COG0779	Required for maturation of 30S ribosomal subunits
I6I22_RS18790	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I22_RS18795	COG0149	triose-phosphate isomerase activity
I6I22_RS18800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I22_RS18805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I22_RS18835	COG0505	Belongs to the CarA family
I6I22_RS18840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I22_RS18845	COG0484	heat shock protein binding
I6I22_RS18850	COG0443	Heat shock 70 kDa protein
I6I22_RS18855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I22_RS18860	COG0497	DNA recombination
I6I22_RS18875	COG2914	Belongs to the UPF0125 (RnfH) family
I6I22_RS18885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I22_RS18895	COG1620	l-lactate permease
I6I22_RS18900	COG0247	lactate metabolic process
I6I22_RS18905	COG1139	Iron-sulfur cluster binding protein
I6I22_RS18935	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6I22_RS18940	COG4974	Belongs to the 'phage' integrase family
I6I22_RS18985	COG4974	Belongs to the 'phage' integrase family
I6I22_RS18990	COG2205	protein histidine kinase activity
I6I22_RS18995	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I6I22_RS19005	COG3842	ATPase activity
I6I22_RS19010	COG0366	Alpha amylase catalytic
I6I22_RS19035	COG3833	ABC-type maltose transport systems, permease component
I6I22_RS19040	COG1175	transmembrane transport
I6I22_RS19050	COG0366	Alpha amylase catalytic
I6I22_RS19065	COG4580	involved in the transport of maltose and maltodextrins
I6I22_RS19080	COG3256	nitric oxide reductase
I6I22_RS19085	COG2010	Cytochrome c
I6I22_RS19110	COG3391	amine dehydrogenase activity
I6I22_RS19115	COG2010	Cytochrome c
I6I22_RS19135	COG2010	Cytochrome c
I6I22_RS19140	COG0714	Associated with various cellular activities
I6I22_RS19145	COG1845	cytochrome c oxidase, subunit III
I6I22_RS19155	COG0535	radical SAM domain protein
I6I22_RS19160	COG1648	precorrin-2 dehydrogenase activity
I6I22_RS19160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I22_RS19175	COG2239	Acts as a magnesium transporter
I6I22_RS19180	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I22_RS19190	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS19210	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6I22_RS19225	COG4263	nitrous-oxide reductase activity
I6I22_RS19230	COG3901	Regulator of nitric oxide reductase transcription
I6I22_RS19230	COG0348	domain, Protein
I6I22_RS19235	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS19265	COG0492	ferredoxin-NADP+ reductase activity
I6I22_RS19270	COG1760	l-serine dehydratase
I6I22_RS19285	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6I22_RS19300	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6I22_RS19305	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6I22_RS19310	COG0402	S-adenosylhomocysteine deaminase activity
I6I22_RS19320	COG1607	acyl-coa hydrolase
I6I22_RS19325	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I22_RS19330	COG1278	Cold shock
I6I22_RS19350	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I22_RS19360	COG3845	ABC transporter
I6I22_RS19395	COG0346	lactoylglutathione lyase activity
I6I22_RS19405	COG1253	flavin adenine dinucleotide binding
I6I22_RS19415	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I22_RS19425	COG0640	Transcriptional regulator
I6I22_RS19430	COG1902	pentaerythritol trinitrate reductase activity
I6I22_RS19435	COG1309	transcriptional regulator
I6I22_RS19470	COG1309	transcriptional regulator
I6I22_RS19475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I22_RS19480	COG1335	isochorismatase
I6I22_RS19485	COG0251	oxidation-reduction process
I6I22_RS19490	COG0596	Alpha beta hydrolase
I6I22_RS19495	COG0778	Nitroreductase
I6I22_RS19500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I22_RS19530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I22_RS19540	COG2814	Major facilitator Superfamily
I6I22_RS19555	COG2217	Heavy metal translocating P-type atpase
I6I22_RS19565	COG0840	transmembrane signaling receptor activity
I6I22_RS19580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I22_RS19585	COG1538	Outer membrane efflux protein
I6I22_RS19595	COG2169	Transcriptional regulator
I6I22_RS19595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I22_RS19605	COG0084	hydrolase, TatD family'
I6I22_RS19620	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I22_RS19625	COG1515	deoxyribonuclease V activity
I6I22_RS19635	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I22_RS19645	COG2945	thiolester hydrolase activity
I6I22_RS19670	COG1252	NADH dehydrogenase
I6I22_RS19750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I22_RS19755	COG0305	Participates in initiation and elongation during chromosome replication
I6I22_RS19760	COG0359	binds to the 23S rRNA
I6I22_RS19770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I22_RS19775	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I22_RS19785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I22_RS19790	COG0557	exoribonuclease II activity
I6I22_RS19805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I22_RS19810	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I22_RS19815	COG0330	HflC and HflK could
I6I22_RS19820	COG0330	HflC and HflK could
I6I22_RS19825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I22_RS19830	COG1923	regulation of RNA biosynthetic process
I6I22_RS19835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I22_RS19840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I22_RS19845	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I22_RS19850	COG0802	atpase or kinase
I6I22_RS19855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I22_RS19855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I22_RS19880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I22_RS19885	COG1454	alcohol dehydrogenase
I6I22_RS19895	COG0531	amino acid
I6I22_RS19900	COG4303	Ethanolamine ammonia lyase large subunit
I6I22_RS19915	COG3228	Belongs to the MtfA family
I6I22_RS19935	COG5001	Diguanylate cyclase
I6I22_RS19945	COG0076	glutamate decarboxylase activity
I6I22_RS19950	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6I22_RS19975	COG1722	exodeoxyribonuclease VII activity
I6I22_RS19980	COG0142	geranyltranstransferase activity
I6I22_RS19985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I22_RS20005	COG1028	Short-chain dehydrogenase reductase Sdr
I6I22_RS20015	COG1643	Atp-dependent helicase
I6I22_RS20035	COG1522	sequence-specific DNA binding
I6I22_RS20080	COG0829	nickel cation binding
I6I22_RS20085	COG0831	urea catabolic process
I6I22_RS20095	COG0832	Belongs to the urease beta subunit family
I6I22_RS20100	COG0804	urea catabolic process
I6I22_RS20110	COG1953	Uracil, thiamine, allantoin
I6I22_RS20120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I22_RS20130	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6I22_RS20145	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I22_RS20150	COG0830	nickel cation binding
I6I22_RS20155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I22_RS20170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I22_RS20175	COG0427	acetyl-CoA hydrolase
I6I22_RS20185	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS20195	COG0351	phosphomethylpyrimidine kinase
I6I22_RS20195	COG0352	thiamine-phosphate diphosphorylase activity
I6I22_RS20200	COG0352	thiamine-phosphate diphosphorylase activity
I6I22_RS20205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I22_RS20220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I22_RS20225	COG1702	phosphate starvation-inducible protein PhoH
I6I22_RS20230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I22_RS20235	COG4535	Mg2 and Co2 transporter CorC
I6I22_RS20240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I22_RS20255	COG0495	leucyl-tRNA aminoacylation
I6I22_RS20275	COG2951	lytic endotransglycosylase activity
I6I22_RS20285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I22_RS20290	COG0321	lipoyl(octanoyl) transferase activity
I6I22_RS20295	COG2921	Belongs to the UPF0250 family
I6I22_RS20300	COG1686	Belongs to the peptidase S11 family
I6I22_RS20310	COG2951	lytic endotransglycosylase activity
I6I22_RS20315	COG0772	Belongs to the SEDS family
I6I22_RS20320	COG0768	penicillin binding
I6I22_RS20325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I22_RS20335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I22_RS20340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I22_RS20345	COG0586	Pfam SNARE associated Golgi protein
I6I22_RS20350	COG2267	carboxylic ester hydrolase activity
I6I22_RS20360	COG1346	cytolysis
I6I22_RS20380	COG0702	epimerase
I6I22_RS20385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I22_RS20395	COG1162	GTPase activity
I6I22_RS20400	COG1360	Flagellar Motor Protein
I6I22_RS20405	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6I22_RS20420	COG0688	phosphatidylethanolamine metabolic process
I6I22_RS20430	COG2200	EAL domain
I6I22_RS20435	COG1063	alcohol dehydrogenase
I6I22_RS20440	COG0560	Phosphoserine phosphatase
I6I22_RS20440	COG3830	Belongs to the UPF0237 family
I6I22_RS20480	COG3150	esterase
I6I22_RS20485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I22_RS20495	COG0494	nUDIX hydrolase
I6I22_RS20505	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I22_RS20510	COG1538	Outer membrane efflux protein
I6I22_RS20515	COG1519	Transferase
I6I22_RS20530	COG0667	Aldo Keto reductase
I6I22_RS20540	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I22_RS20540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I22_RS20545	COG2755	lipolytic protein G-D-S-L family
I6I22_RS20545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I22_RS20560	COG1132	(ABC) transporter
I6I22_RS20590	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I22_RS20610	COG0438	transferase activity, transferring glycosyl groups
I6I22_RS20615	COG2192	nodulation
I6I22_RS20635	COG0438	transferase activity, transferring glycosyl groups
I6I22_RS20640	COG0859	PFAM glycosyl transferase family 9
I6I22_RS20645	COG0859	PFAM glycosyl transferase family 9
I6I22_RS20655	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I22_RS20680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I22_RS20685	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS20695	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS20715	COG1073	alpha beta
I6I22_RS20715	COG2226	methyltransferase
I6I22_RS20720	COG0156	8-amino-7-oxononanoate synthase activity
I6I22_RS20725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I22_RS20730	COG1040	competence protein
I6I22_RS20735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I22_RS20740	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I22_RS20775	COG1304	FMN binding
I6I22_RS20785	COG1960	acyl-CoA dehydrogenase activity
I6I22_RS20790	COG3263	regulation of cellular component size
I6I22_RS20795	COG1196	nuclear chromosome segregation
I6I22_RS20795	COG3264	Mechanosensitive ion channel
I6I22_RS20800	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I22_RS20815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I22_RS20820	COG2205	protein histidine kinase activity
I6I22_RS20820	COG3437	response regulator, receiver
I6I22_RS20820	COG3850	Histidine kinase
I6I22_RS20820	COG4999	Histidine kinase
I6I22_RS20845	COG0330	HflC and HflK could
I6I22_RS20870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I22_RS20910	COG0529	Catalyzes the synthesis of activated sulfate
I6I22_RS20935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity