locus-tag	class	description
I6G32_RS00005	COG0215	cysteine-tRNA ligase activity
I6G32_RS00010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G32_RS00030	COG2186	Transcriptional regulator
I6G32_RS00040	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G32_RS00050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6G32_RS00055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G32_RS00065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G32_RS00090	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G32_RS00095	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I6G32_RS00105	COG0535	radical SAM domain protein
I6G32_RS00120	COG5002	protein histidine kinase activity
I6G32_RS00135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G32_RS00140	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G32_RS00185	COG0798	PFAM Bile acid sodium symporter
I6G32_RS00190	COG2072	flavoprotein involved in K transport
I6G32_RS00195	COG0640	Transcriptional regulator
I6G32_RS00200	COG0431	NADPH-dependent FMN reductase
I6G32_RS00210	COG1742	UPF0060 membrane protein
I6G32_RS00215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G32_RS00240	COG5642	Protein of unknown function (DUF2384)
I6G32_RS00290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G32_RS00315	COG1566	PFAM secretion protein HlyD family protein
I6G32_RS00325	COG0583	DNA-binding transcription factor activity
I6G32_RS00340	COG0723	plastoquinol--plastocyanin reductase activity
I6G32_RS00345	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS00350	COG0028	Belongs to the TPP enzyme family
I6G32_RS00375	COG3685	Protein conserved in bacteria
I6G32_RS00380	COG3264	Mechanosensitive ion channel
I6G32_RS00380	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6G32_RS00385	COG1546	Belongs to the CinA family
I6G32_RS00385	COG1058	Belongs to the CinA family
I6G32_RS00390	COG0297	glycogen (starch) synthase activity
I6G32_RS00395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G32_RS00420	COG0739	heme binding
I6G32_RS00425	COG3038	cytochrome b561
I6G32_RS00430	COG3384	dioxygenase
I6G32_RS00435	COG0583	DNA-binding transcription factor activity
I6G32_RS00450	COG3568	Endonuclease Exonuclease Phosphatase
I6G32_RS00455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G32_RS00460	COG0392	lysyltransferase activity
I6G32_RS00465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G32_RS00470	COG0366	Alpha amylase catalytic
I6G32_RS00490	COG2864	formate dehydrogenase
I6G32_RS00495	COG0437	4 iron, 4 sulfur cluster binding
I6G32_RS00515	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS00520	COG3321	synthase
I6G32_RS00520	COG0604	alcohol dehydrogenase
I6G32_RS00520	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS00570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G32_RS00580	COG0728	peptidoglycan biosynthetic process
I6G32_RS00595	COG1115	amino acid carrier protein
I6G32_RS00600	COG2911	Protein conserved in bacteria
I6G32_RS00605	COG0729	surface antigen
I6G32_RS00625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G32_RS00640	COG1175	transmembrane transport
I6G32_RS00660	COG1070	Carbohydrate kinase
I6G32_RS00675	COG1609	Transcriptional regulator
I6G32_RS00680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G32_RS00685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6G32_RS00690	COG3265	gluconokinase activity
I6G32_RS00695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G32_RS00700	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G32_RS00725	COG0488	(ABC) transporter
I6G32_RS00730	COG1968	undecaprenyl-diphosphatase activity
I6G32_RS00735	COG0840	transmembrane signaling receptor activity
I6G32_RS00750	COG2323	membrane
I6G32_RS00765	COG3706	GGDEF domain
I6G32_RS00770	COG2201	protein-glutamate methylesterase activity
I6G32_RS00775	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6G32_RS00775	COG0316	Belongs to the HesB IscA family
I6G32_RS00795	COG2755	lipolytic protein G-D-S-L family
I6G32_RS00795	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6G32_RS00820	COG2223	nitrite transmembrane transporter activity
I6G32_RS00825	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G32_RS00840	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G32_RS00860	COG0604	alcohol dehydrogenase
I6G32_RS00865	COG0616	signal peptide processing
I6G32_RS00885	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS00900	COG2816	NAD+ diphosphatase activity
I6G32_RS00910	COG1024	Enoyl-CoA hydratase
I6G32_RS00920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G32_RS00925	COG0328	RNA-DNA hybrid ribonuclease activity
I6G32_RS00935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G32_RS00940	COG1388	LysM domain
I6G32_RS00940	COG0741	lytic transglycosylase activity
I6G32_RS00950	COG4166	transmembrane transport
I6G32_RS00960	COG4174	ABC transporter (Permease)
I6G32_RS00965	COG4239	(ABC) transporter, permease
I6G32_RS00970	COG4172	Belongs to the ABC transporter superfamily
I6G32_RS00980	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS01000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G32_RS01065	COG0840	transmembrane signaling receptor activity
I6G32_RS01085	COG1131	(ABC) transporter
I6G32_RS01105	COG1648	precorrin-2 dehydrogenase activity
I6G32_RS01105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G32_RS01110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G32_RS01115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G32_RS01120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G32_RS01125	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G32_RS01135	COG0492	ferredoxin-NADP+ reductase activity
I6G32_RS01140	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6G32_RS01145	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6G32_RS01150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G32_RS01155	COG0542	response to heat
I6G32_RS01160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6G32_RS01185	COG0482	sulfurtransferase activity
I6G32_RS01190	COG2915	High frequency lysogenization protein hflD homolog
I6G32_RS01200	COG2850	peptidyl-arginine hydroxylation
I6G32_RS01205	COG2153	protein acetylation
I6G32_RS01235	COG2056	Na+-H+ antiporter family
I6G32_RS01240	COG0720	synthase
I6G32_RS01270	COG0402	S-adenosylhomocysteine deaminase activity
I6G32_RS01275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G32_RS01280	COG0546	phosphoglycolate phosphatase activity
I6G32_RS01285	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS01295	COG0800	Aldolase
I6G32_RS01320	COG2840	Smr protein MutS2
I6G32_RS01330	COG0625	glutathione transferase activity
I6G32_RS01335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G32_RS01350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G32_RS01355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G32_RS01365	COG1605	Chorismate mutase
I6G32_RS01365	COG0077	Prephenate dehydratase
I6G32_RS01370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6G32_RS01380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6G32_RS01395	COG0587	DNA-directed DNA polymerase activity
I6G32_RS01410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G32_RS01415	COG0765	amino acid transport
I6G32_RS01435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G32_RS01440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G32_RS01440	COG0475	glutathione-regulated potassium exporter activity
I6G32_RS01495	COG4983	Phage plasmid primase, P4 family domain protein
I6G32_RS01535	COG2003	Belongs to the UPF0758 family
I6G32_RS01555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G32_RS01570	COG1484	DNA-dependent DNA replication
I6G32_RS01575	COG4584	PFAM Integrase catalytic
I6G32_RS01595	COG0776	regulation of translation
I6G32_RS01600	COG0072	phenylalanine-tRNA ligase activity
I6G32_RS01605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G32_RS01610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G32_RS01615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G32_RS01625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G32_RS01635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G32_RS01710	COG3171	Protein conserved in bacteria
I6G32_RS01715	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G32_RS01720	COG0116	Belongs to the methyltransferase superfamily
I6G32_RS01720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G32_RS01725	COG3130	regulation of translation
I6G32_RS01730	COG0167	dihydroorotate dehydrogenase activity
I6G32_RS01750	COG0714	Associated with various cellular activities
I6G32_RS01780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G32_RS01785	COG3707	response regulator
I6G32_RS01805	COG2223	nitrite transmembrane transporter activity
I6G32_RS01810	COG2815	serine threonine protein kinase
I6G32_RS01810	COG0515	serine threonine protein kinase
I6G32_RS01820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G32_RS01825	COG2146	nitrite reductase [NAD(P)H] activity
I6G32_RS01830	COG0243	molybdopterin cofactor binding
I6G32_RS01850	COG0308	aminopeptidase N
I6G32_RS01870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G32_RS01875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G32_RS01890	COG0730	response to heat
I6G32_RS01905	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6G32_RS01930	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6G32_RS01940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6G32_RS01955	COG4580	involved in the transport of maltose and maltodextrins
I6G32_RS01960	COG3842	ATPase activity
I6G32_RS01965	COG0395	ABC-type sugar transport system, permease component
I6G32_RS01970	COG1175	transmembrane transport
I6G32_RS01975	COG1653	transport
I6G32_RS02000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G32_RS02010	COG0180	Tryptophanyl-tRNA synthetase
I6G32_RS02015	COG0009	L-threonylcarbamoyladenylate synthase
I6G32_RS02020	COG0613	PHP domain protein
I6G32_RS02025	COG2350	Protein conserved in bacteria
I6G32_RS02035	COG0745	RESPONSE REGULATOR receiver
I6G32_RS02050	COG0778	Nitroreductase
I6G32_RS02055	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6G32_RS02060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G32_RS02065	COG2354	Protein conserved in bacteria
I6G32_RS02085	COG2207	Transcriptional regulator
I6G32_RS02100	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G32_RS02110	COG0514	ATP-dependent DNA helicase (RecQ)
I6G32_RS02120	COG2832	Protein of unknown function (DUF454)
I6G32_RS02135	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6G32_RS02145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G32_RS02155	COG0542	response to heat
I6G32_RS02175	COG0121	glutamine amidotransferase
I6G32_RS02185	COG0589	response to stress
I6G32_RS02195	COG0488	(ABC) transporter
I6G32_RS02200	COG0741	lytic transglycosylase activity
I6G32_RS02205	COG0633	Ferredoxin
I6G32_RS02205	COG3217	Mosc domain protein beta barrel domain protein
I6G32_RS02210	COG3437	response regulator, receiver
I6G32_RS02220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G32_RS02225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G32_RS02230	COG0489	protein tyrosine kinase activity
I6G32_RS02230	COG3206	protein involved in exopolysaccharide biosynthesis
I6G32_RS02235	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I6G32_RS02280	COG0183	Belongs to the thiolase family
I6G32_RS02305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G32_RS02315	COG1215	transferase activity, transferring glycosyl groups
I6G32_RS02320	COG1216	Glycosyl transferase, family 2
I6G32_RS02330	COG0463	Glycosyl transferase, family 2
I6G32_RS02350	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6G32_RS02355	COG3206	protein involved in exopolysaccharide biosynthesis
I6G32_RS02355	COG0489	protein tyrosine kinase activity
I6G32_RS02360	COG0489	protein tyrosine kinase activity
I6G32_RS02360	COG3206	protein involved in exopolysaccharide biosynthesis
I6G32_RS02365	COG0776	regulation of translation
I6G32_RS02385	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6G32_RS02390	COG0471	metal ion transport
I6G32_RS02395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G32_RS02475	COG1484	DNA-dependent DNA replication
I6G32_RS02480	COG4584	PFAM Integrase catalytic
I6G32_RS02490	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
I6G32_RS02515	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G32_RS02520	COG1136	(ABC) transporter
I6G32_RS02530	COG3453	Protein conserved in bacteria
I6G32_RS02530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G32_RS02560	COG0640	Transcriptional regulator
I6G32_RS02570	COG0583	DNA-binding transcription factor activity
I6G32_RS02580	COG2894	cell division
I6G32_RS02615	COG4584	PFAM Integrase catalytic
I6G32_RS02620	COG1484	DNA-dependent DNA replication
I6G32_RS02650	COG0604	alcohol dehydrogenase
I6G32_RS02655	COG1902	pentaerythritol trinitrate reductase activity
I6G32_RS02660	COG0640	Transcriptional regulator
I6G32_RS02745	COG2003	Belongs to the UPF0758 family
I6G32_RS02795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G32_RS02905	COG0386	Belongs to the glutathione peroxidase family
I6G32_RS02910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G32_RS02915	COG0436	Aminotransferase
I6G32_RS02925	COG0501	Belongs to the peptidase M48B family
I6G32_RS02935	COG0500	methyltransferase
I6G32_RS02985	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6G32_RS03015	COG2257	FlhB HrpN YscU SpaS Family
I6G32_RS03030	COG0835	chemotaxis
I6G32_RS03040	COG1192	Involved in chromosome partitioning
I6G32_RS03045	COG1360	Flagellar Motor Protein
I6G32_RS03050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G32_RS03055	COG2201	protein-glutamate methylesterase activity
I6G32_RS03060	COG0643	Histidine kinase
I6G32_RS03060	COG2198	Histidine kinase
I6G32_RS03060	COG0784	Response regulator, receiver
I6G32_RS03065	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6G32_RS03095	COG2032	superoxide dismutase activity
I6G32_RS03110	COG1987	bacterial-type flagellum assembly
I6G32_RS03150	COG0745	RESPONSE REGULATOR receiver
I6G32_RS03185	COG1677	Flagellar hook-basal body complex protein FliE
I6G32_RS03190	COG3135	benzoate transporter
I6G32_RS03200	COG2130	NADP-dependent
I6G32_RS03215	COG5001	Diguanylate cyclase
I6G32_RS03215	COG3300	MHYT domain
I6G32_RS03225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G32_RS03285	COG1113	amino acid transport
I6G32_RS03290	COG0084	hydrolase, TatD family'
I6G32_RS03305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G32_RS03310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G32_RS03320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G32_RS03325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G32_RS03340	COG0416	fatty acid biosynthetic process
I6G32_RS03345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G32_RS03355	COG0424	maF-like protein
I6G32_RS03360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G32_RS03360	COG0616	signal peptide processing
I6G32_RS03375	COG1530	ribonuclease E activity
I6G32_RS03380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G32_RS03385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G32_RS03390	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6G32_RS03395	COG2835	tetraacyldisaccharide 4'-kinase activity
I6G32_RS03400	COG1663	tetraacyldisaccharide 4'-kinase activity
I6G32_RS03410	COG0811	peptide transport
I6G32_RS03415	COG2333	competence protein COMEC
I6G32_RS03415	COG0658	competence protein
I6G32_RS03430	COG1136	(ABC) transporter
I6G32_RS03435	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G32_RS03450	COG0584	glycerophosphoryl diester phosphodiesterase
I6G32_RS03455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G32_RS03465	COG1477	protein flavinylation
I6G32_RS03475	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6G32_RS03490	COG1805	sodium ion transport
I6G32_RS03505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G32_RS03515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G32_RS03530	COG1793	dna ligase
I6G32_RS03535	COG1201	RNA secondary structure unwinding
I6G32_RS03565	COG3956	TIGRFAM MazG family protein
I6G32_RS03570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G32_RS03575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G32_RS03590	COG2860	membrane
I6G32_RS03600	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6G32_RS03600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G32_RS03620	COG0583	DNA-binding transcription factor activity
I6G32_RS03635	COG0513	Belongs to the DEAD box helicase family
I6G32_RS03680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G32_RS03685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G32_RS03690	COG2226	methyltransferase
I6G32_RS03715	COG1131	(ABC) transporter
I6G32_RS03720	COG0456	acetyltransferase
I6G32_RS03745	COG2937	Belongs to the GPAT DAPAT family
I6G32_RS03750	COG0456	acetyltransferase
I6G32_RS03765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G32_RS03780	COG0642	Histidine kinase
I6G32_RS03805	COG2132	Multicopper oxidase
I6G32_RS03830	COG0456	acetyltransferase
I6G32_RS03835	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6G32_RS03850	COG2943	transferase activity, transferring hexosyl groups
I6G32_RS03860	COG1472	Belongs to the glycosyl hydrolase 3 family
I6G32_RS03870	COG1346	cytolysis
I6G32_RS03875	COG1380	Effector of murein hydrolase LrgA
I6G32_RS03880	COG0348	domain, Protein
I6G32_RS03885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G32_RS03910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G32_RS03915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G32_RS03925	COG0742	ribosomal rna small subunit methyltransferase
I6G32_RS03950	COG0563	adenylate kinase activity
I6G32_RS03955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6G32_RS03995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G32_RS04010	COG1902	pentaerythritol trinitrate reductase activity
I6G32_RS04015	COG0243	molybdopterin cofactor binding
I6G32_RS04020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G32_RS04035	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G32_RS04040	COG1984	allophanate hydrolase subunit 2
I6G32_RS04045	COG4336	lyase activity
I6G32_RS04050	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G32_RS04075	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G32_RS04090	COG2974	May be involved in recombination
I6G32_RS04095	COG2814	Major facilitator Superfamily
I6G32_RS04115	COG2205	protein histidine kinase activity
I6G32_RS04120	COG3174	membrane
I6G32_RS04155	COG0417	DNA replication proofreading
I6G32_RS04175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G32_RS04275	COG2135	peptidase activity
I6G32_RS04285	COG3039	Transposase
I6G32_RS04295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G32_RS04300	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G32_RS04315	COG0789	Transcriptional regulator
I6G32_RS04365	COG0582	viral genome integration into host DNA
I6G32_RS04375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G32_RS04385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G32_RS04395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G32_RS04405	COG0425	Belongs to the sulfur carrier protein TusA family
I6G32_RS04415	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6G32_RS04420	COG0427	acetyl-CoA hydrolase
I6G32_RS04430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6G32_RS04435	COG0602	queuosine metabolic process
I6G32_RS04440	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6G32_RS04445	COG2885	chlorophyll binding
I6G32_RS04450	COG0823	Involved in the tonB-independent uptake of proteins
I6G32_RS04470	COG0824	Thioesterase
I6G32_RS04475	COG2255	four-way junction helicase activity
I6G32_RS04480	COG0632	four-way junction helicase activity
I6G32_RS04485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6G32_RS04495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G32_RS04500	COG0783	Belongs to the Dps family
I6G32_RS04510	COG2900	Belongs to the SlyX family
I6G32_RS04525	COG0442	prolyl-tRNA aminoacylation
I6G32_RS04540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G32_RS04555	COG1295	ribonuclease BN
I6G32_RS04560	COG1393	Belongs to the ArsC family
I6G32_RS04575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G32_RS04580	COG0628	permease
I6G32_RS04590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G32_RS04595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G32_RS04610	COG0436	Aminotransferase
I6G32_RS04630	COG1393	Belongs to the ArsC family
I6G32_RS04635	COG2171	N-acyltransferase activity
I6G32_RS04640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G32_RS04645	COG2166	iron-sulfur cluster assembly
I6G32_RS04655	COG3258	Cytochrome c
I6G32_RS04660	COG2863	cytochrome
I6G32_RS04670	COG3530	Putative quorum-sensing-regulated virulence factor
I6G32_RS04680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G32_RS04690	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G32_RS04695	COG3932	Exopolysaccharide synthesis, ExoD
I6G32_RS04700	COG0583	DNA-binding transcription factor activity
I6G32_RS04705	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS04715	COG1280	lysine exporter protein (LysE YggA)
I6G32_RS04735	COG1462	curli production assembly transport component CsgG
I6G32_RS04755	COG1309	transcriptional regulator
I6G32_RS04760	COG0583	DNA-binding transcription factor activity
I6G32_RS04765	COG0189	ligase activity
I6G32_RS04765	COG4067	protein conserved in archaea
I6G32_RS04770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G32_RS04770	COG0116	Belongs to the methyltransferase superfamily
I6G32_RS04790	COG3321	synthase
I6G32_RS04790	COG0604	alcohol dehydrogenase
I6G32_RS04800	COG3284	Transcriptional regulator
I6G32_RS04815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G32_RS04820	COG1063	alcohol dehydrogenase
I6G32_RS04825	COG0022	dehydrogenase e1 component
I6G32_RS04830	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G32_RS04835	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G32_RS04865	COG0583	DNA-binding transcription factor activity
I6G32_RS04870	COG0625	glutathione transferase activity
I6G32_RS04895	COG0659	secondary active sulfate transmembrane transporter activity
I6G32_RS04905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G32_RS04915	COG1696	Membrane protein involved in D-alanine export
I6G32_RS04925	COG1280	lysine exporter protein (LysE YggA)
I6G32_RS04945	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I6G32_RS04955	COG4249	Peptidase C14 caspase catalytic subunit p20
I6G32_RS04960	COG1132	(ABC) transporter
I6G32_RS05000	COG0159	tryptophan synthase activity
I6G32_RS05015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G32_RS05025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G32_RS05035	COG4221	oxidoreductase activity
I6G32_RS05045	COG2207	Transcriptional regulator
I6G32_RS05050	COG3845	ABC transporter
I6G32_RS05055	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6G32_RS05060	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6G32_RS05075	COG1301	dicarboxylic acid transport
I6G32_RS05085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G32_RS05090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G32_RS05100	COG0490	domain, Protein
I6G32_RS05100	COG0471	metal ion transport
I6G32_RS05110	COG2814	Major facilitator Superfamily
I6G32_RS05120	COG0596	Alpha beta hydrolase
I6G32_RS05120	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G32_RS05145	COG1279	arginine transmembrane transporter activity
I6G32_RS05170	COG2733	membrane
I6G32_RS05190	COG0537	adenosine 5'-monophosphoramidase activity
I6G32_RS05200	COG2258	MOSC domain
I6G32_RS05215	COG3795	YCII-related domain
I6G32_RS05230	COG2851	Citrate transporter
I6G32_RS05240	COG1234	tRNA 3'-trailer cleavage
I6G32_RS05255	COG3257	ureidoglycine aminohydrolase activity
I6G32_RS05260	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6G32_RS05265	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6G32_RS05270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G32_RS05275	COG0631	protein serine/threonine phosphatase activity
I6G32_RS05280	COG2815	serine threonine protein kinase
I6G32_RS05280	COG0515	serine threonine protein kinase
I6G32_RS05295	COG1643	Atp-dependent helicase
I6G32_RS05320	COG2030	dehydratase
I6G32_RS05345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G32_RS05355	COG0443	Heat shock 70 kDa protein
I6G32_RS05365	COG2271	Major facilitator Superfamily
I6G32_RS05375	COG2084	Dehydrogenase
I6G32_RS05380	COG1968	undecaprenyl-diphosphatase activity
I6G32_RS05390	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6G32_RS05400	COG3639	organic phosphonate transmembrane transporter activity
I6G32_RS05405	COG3639	organic phosphonate transmembrane transporter activity
I6G32_RS05455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G32_RS05490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G32_RS05495	COG0556	nucleotide-excision repair
I6G32_RS05515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G32_RS05525	COG3842	ATPase activity
I6G32_RS05530	COG0590	tRNA wobble adenosine to inosine editing
I6G32_RS05535	COG2132	Multicopper oxidase
I6G32_RS05555	COG0765	amino acid transport
I6G32_RS05560	COG0165	Argininosuccinate lyase
I6G32_RS05570	COG1126	abc transporter atp-binding protein
I6G32_RS05575	COG0519	Catalyzes the synthesis of GMP from XMP
I6G32_RS05575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G32_RS05590	COG1570	exodeoxyribonuclease VII activity
I6G32_RS05595	COG0739	heme binding
I6G32_RS05605	COG0668	transmembrane transport
I6G32_RS05620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G32_RS05625	COG1064	alcohol dehydrogenase
I6G32_RS05635	COG2356	endonuclease I
I6G32_RS05640	COG3647	Membrane
I6G32_RS05650	COG2264	protein methyltransferase activity
I6G32_RS05665	COG0436	Aminotransferase
I6G32_RS05670	COG1045	serine acetyltransferase
I6G32_RS05675	COG1160	GTP binding
I6G32_RS05685	COG2976	Protein conserved in bacteria
I6G32_RS05690	COG0124	histidyl-tRNA synthetase
I6G32_RS05695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6G32_RS05710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G32_RS05715	COG0105	UTP biosynthetic process
I6G32_RS05730	COG0443	Heat shock 70 kDa protein
I6G32_RS05735	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G32_RS05740	COG0316	Belongs to the HesB IscA family
I6G32_RS05750	COG1104	cysteine desulfurase activity
I6G32_RS05775	COG3134	Outer membrane lipoprotein
I6G32_RS05790	COG1862	Preprotein translocase
I6G32_RS05810	COG1278	Cold shock
I6G32_RS05820	COG0795	lipopolysaccharide-transporting ATPase activity
I6G32_RS05825	COG0795	lipopolysaccharide-transporting ATPase activity
I6G32_RS05830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G32_RS05860	COG0490	domain, Protein
I6G32_RS05860	COG0471	metal ion transport
I6G32_RS05865	COG0477	Major facilitator Superfamily
I6G32_RS05870	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6G32_RS05890	COG3081	Nucleoid-associated protein
I6G32_RS05895	COG2326	polyphosphate kinase activity
I6G32_RS05915	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G32_RS05920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G32_RS05960	COG0402	S-adenosylhomocysteine deaminase activity
I6G32_RS05965	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G32_RS05975	COG1121	(ABC) transporter
I6G32_RS05980	COG1802	Transcriptional regulator
I6G32_RS05985	COG2252	PERMEase
I6G32_RS06010	COG4266	Belongs to the allantoicase family
I6G32_RS06015	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6G32_RS06025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G32_RS06040	COG1309	transcriptional regulator
I6G32_RS06065	COG3300	MHYT domain
I6G32_RS06065	COG5001	Diguanylate cyclase
I6G32_RS06070	COG0708	Exodeoxyribonuclease III
I6G32_RS06090	COG2351	hydroxyisourate hydrolase activity
I6G32_RS06095	COG0583	DNA-binding transcription factor activity
I6G32_RS06100	COG3960	tartronate-semialdehyde synthase activity
I6G32_RS06105	COG3622	Belongs to the hyi family
I6G32_RS06110	COG2084	Dehydrogenase
I6G32_RS06120	COG0469	pyruvate kinase activity
I6G32_RS06125	COG4413	Urea transporter
I6G32_RS06135	COG1017	nitric oxide dioxygenase activity
I6G32_RS06135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G32_RS06150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G32_RS06155	COG3706	GGDEF domain
I6G32_RS06175	COG0583	DNA-binding transcription factor activity
I6G32_RS06205	COG1704	LemA family
I6G32_RS06235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G32_RS06240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G32_RS06250	COG0459	protein refolding
I6G32_RS06255	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G32_RS06260	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6G32_RS06270	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS06290	COG0668	transmembrane transport
I6G32_RS06295	COG1666	GTP binding
I6G32_RS06300	COG0745	RESPONSE REGULATOR receiver
I6G32_RS06315	COG2096	Adenosyltransferase
I6G32_RS06355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6G32_RS06360	COG0653	protein targeting
I6G32_RS06400	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G32_RS06405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G32_RS06425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G32_RS06430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G32_RS06440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G32_RS06445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6G32_RS06455	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6G32_RS06460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G32_RS06480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G32_RS06505	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G32_RS06535	COG0318	PFAM AMP-dependent synthetase and ligase
I6G32_RS06540	COG4294	response to UV
I6G32_RS06545	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS06550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G32_RS06555	COG1024	Enoyl-CoA hydratase
I6G32_RS06585	COG0789	Transcriptional regulator
I6G32_RS06590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6G32_RS06600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6G32_RS06615	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6G32_RS06645	COG3039	Transposase
I6G32_RS06705	COG0697	spore germination
I6G32_RS06710	COG0288	reversible hydration of carbon dioxide
I6G32_RS06715	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6G32_RS06730	COG0456	acetyltransferase
I6G32_RS06740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G32_RS06750	COG0019	diaminopimelate decarboxylase activity
I6G32_RS06770	COG3008	intermembrane lipid transfer
I6G32_RS06775	COG2995	paraquat-inducible protein a
I6G32_RS06780	COG2995	paraquat-inducible protein a
I6G32_RS06820	COG1183	phosphatidylcholine synthase activity
I6G32_RS06825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G32_RS06835	COG0028	Belongs to the TPP enzyme family
I6G32_RS06855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G32_RS06890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G32_RS06905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6G32_RS06920	COG2264	protein methyltransferase activity
I6G32_RS06940	COG0138	bifunctional purine biosynthesis protein purh
I6G32_RS06950	COG2205	protein histidine kinase activity
I6G32_RS06950	COG5002	protein histidine kinase activity
I6G32_RS06950	COG0784	Response regulator, receiver
I6G32_RS06955	COG2124	cytochrome p450
I6G32_RS06970	COG0679	Auxin Efflux Carrier
I6G32_RS06985	COG0436	Aminotransferase
I6G32_RS06990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G32_RS06995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G32_RS07005	COG4191	Histidine kinase
I6G32_RS07025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6G32_RS07030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G32_RS07035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6G32_RS07040	COG0166	Belongs to the GPI family
I6G32_RS07050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G32_RS07075	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G32_RS07080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G32_RS07085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G32_RS07090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G32_RS07095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G32_RS07100	COG2251	uridine kinase activity
I6G32_RS07100	COG0195	Participates in both transcription termination and antitermination
I6G32_RS07105	COG0779	Required for maturation of 30S ribosomal subunits
I6G32_RS07120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G32_RS07125	COG0149	triose-phosphate isomerase activity
I6G32_RS07130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G32_RS07135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G32_RS07165	COG0505	Belongs to the CarA family
I6G32_RS07170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G32_RS07175	COG0484	heat shock protein binding
I6G32_RS07180	COG0443	Heat shock 70 kDa protein
I6G32_RS07185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G32_RS07190	COG0497	DNA recombination
I6G32_RS07200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G32_RS07205	COG2914	Belongs to the UPF0125 (RnfH) family
I6G32_RS07215	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G32_RS07225	COG1620	l-lactate permease
I6G32_RS07230	COG0247	lactate metabolic process
I6G32_RS07235	COG1139	Iron-sulfur cluster binding protein
I6G32_RS07260	COG0582	viral genome integration into host DNA
I6G32_RS07270	COG4584	PFAM Integrase catalytic
I6G32_RS07275	COG1484	DNA-dependent DNA replication
I6G32_RS07280	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6G32_RS07295	COG1401	restriction endodeoxyribonuclease activity
I6G32_RS07295	COG1401	restriction endodeoxyribonuclease activity
I6G32_RS07300	COG0732	type I restriction modification DNA specificity domain
I6G32_RS07305	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G32_RS07400	COG4584	PFAM Integrase catalytic
I6G32_RS07405	COG1484	DNA-dependent DNA replication
I6G32_RS07420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G32_RS07425	COG1074	ATP-dependent DNA helicase activity
I6G32_RS07430	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G32_RS07455	COG3039	Transposase
I6G32_RS07485	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6G32_RS07495	COG0582	viral genome integration into host DNA
I6G32_RS07550	COG4191	Histidine kinase
I6G32_RS07550	COG0784	Response regulator, receiver
I6G32_RS07560	COG0366	Alpha amylase catalytic
I6G32_RS07580	COG2909	trisaccharide binding
I6G32_RS07585	COG3833	ABC-type maltose transport systems, permease component
I6G32_RS07590	COG1175	transmembrane transport
I6G32_RS07600	COG0366	Alpha amylase catalytic
I6G32_RS07615	COG4580	involved in the transport of maltose and maltodextrins
I6G32_RS07630	COG4989	oxidoreductase activity
I6G32_RS07640	COG0800	Aldolase
I6G32_RS07655	COG1737	Transcriptional regulator
I6G32_RS07675	COG2814	Major facilitator Superfamily
I6G32_RS07725	COG3154	lipid carrier protein
I6G32_RS07730	COG0826	peptidase U32
I6G32_RS07735	COG0826	peptidase U32
I6G32_RS07745	COG3604	Transcriptional regulator
I6G32_RS07775	COG3256	nitric oxide reductase
I6G32_RS07780	COG2010	Cytochrome c
I6G32_RS07805	COG3391	amine dehydrogenase activity
I6G32_RS07810	COG2010	Cytochrome c
I6G32_RS07825	COG0714	Associated with various cellular activities
I6G32_RS07830	COG1845	cytochrome c oxidase, subunit III
I6G32_RS07840	COG0535	radical SAM domain protein
I6G32_RS07845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G32_RS07845	COG1648	precorrin-2 dehydrogenase activity
I6G32_RS07865	COG3278	Belongs to the heme-copper respiratory oxidase family
I6G32_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS07895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G32_RS07910	COG4263	nitrous-oxide reductase activity
I6G32_RS07915	COG0348	domain, Protein
I6G32_RS07915	COG3901	Regulator of nitric oxide reductase transcription
I6G32_RS07920	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS07935	COG3189	MarR family transcriptional regulator
I6G32_RS07945	COG0492	ferredoxin-NADP+ reductase activity
I6G32_RS07950	COG1760	l-serine dehydratase
I6G32_RS07970	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6G32_RS07985	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6G32_RS08000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6G32_RS08005	COG0402	S-adenosylhomocysteine deaminase activity
I6G32_RS08015	COG1607	acyl-coa hydrolase
I6G32_RS08020	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G32_RS08025	COG1278	Cold shock
I6G32_RS08045	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6G32_RS08055	COG3845	ABC transporter
I6G32_RS08090	COG0346	lactoylglutathione lyase activity
I6G32_RS08100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G32_RS08110	COG4977	sequence-specific DNA binding
I6G32_RS08125	COG1309	transcriptional regulator
I6G32_RS08130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G32_RS08135	COG1335	isochorismatase
I6G32_RS08140	COG0251	oxidation-reduction process
I6G32_RS08145	COG0596	Alpha beta hydrolase
I6G32_RS08150	COG0778	Nitroreductase
I6G32_RS08155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G32_RS08185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G32_RS08195	COG2814	Major facilitator Superfamily
I6G32_RS08210	COG2217	Heavy metal translocating P-type atpase
I6G32_RS08220	COG0840	transmembrane signaling receptor activity
I6G32_RS08235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G32_RS08240	COG1538	Outer membrane efflux protein
I6G32_RS08250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G32_RS08250	COG2169	Transcriptional regulator
I6G32_RS08260	COG0084	hydrolase, TatD family'
I6G32_RS08265	COG0840	transmembrane signaling receptor activity
I6G32_RS08275	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G32_RS08280	COG1515	deoxyribonuclease V activity
I6G32_RS08290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G32_RS08295	COG0180	Tryptophanyl-tRNA synthetase
I6G32_RS08300	COG2945	thiolester hydrolase activity
I6G32_RS08325	COG1252	NADH dehydrogenase
I6G32_RS08400	COG5001	Diguanylate cyclase
I6G32_RS08400	COG3300	MHYT domain
I6G32_RS08405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G32_RS08410	COG0305	Participates in initiation and elongation during chromosome replication
I6G32_RS08415	COG0359	binds to the 23S rRNA
I6G32_RS08425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G32_RS08430	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G32_RS08435	COG4191	Histidine kinase
I6G32_RS08435	COG0784	Response regulator, receiver
I6G32_RS08440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G32_RS08445	COG0557	exoribonuclease II activity
I6G32_RS08460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G32_RS08465	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6G32_RS08470	COG0330	HflC and HflK could
I6G32_RS08475	COG0330	HflC and HflK could
I6G32_RS08480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G32_RS08485	COG1923	regulation of RNA biosynthetic process
I6G32_RS08490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G32_RS08495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G32_RS08500	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G32_RS08505	COG0802	atpase or kinase
I6G32_RS08510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G32_RS08510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G32_RS08535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G32_RS08545	COG0531	amino acid
I6G32_RS08550	COG4303	Ethanolamine ammonia lyase large subunit
I6G32_RS08570	COG3228	Belongs to the MtfA family
I6G32_RS08595	COG5001	Diguanylate cyclase
I6G32_RS08595	COG3300	MHYT domain
I6G32_RS08605	COG0076	glutamate decarboxylase activity
I6G32_RS08610	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6G32_RS08635	COG1722	exodeoxyribonuclease VII activity
I6G32_RS08640	COG0142	geranyltranstransferase activity
I6G32_RS08645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6G32_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS08675	COG1643	Atp-dependent helicase
I6G32_RS08695	COG1522	sequence-specific DNA binding
I6G32_RS08745	COG0829	nickel cation binding
I6G32_RS08750	COG0831	urea catabolic process
I6G32_RS08760	COG0832	Belongs to the urease beta subunit family
I6G32_RS08765	COG0804	urea catabolic process
I6G32_RS08770	COG1953	Uracil, thiamine, allantoin
I6G32_RS08780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G32_RS08790	COG2814	Major facilitator Superfamily
I6G32_RS08795	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6G32_RS08810	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6G32_RS08815	COG0830	nickel cation binding
I6G32_RS08820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6G32_RS08835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G32_RS08840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G32_RS08855	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS08860	COG3437	response regulator, receiver
I6G32_RS08860	COG3850	Histidine kinase
I6G32_RS08860	COG2205	protein histidine kinase activity
I6G32_RS08860	COG4999	Histidine kinase
I6G32_RS08865	COG0352	thiamine-phosphate diphosphorylase activity
I6G32_RS08865	COG0351	phosphomethylpyrimidine kinase
I6G32_RS08865	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G32_RS08870	COG0352	thiamine-phosphate diphosphorylase activity
I6G32_RS08875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G32_RS08890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G32_RS08895	COG1702	phosphate starvation-inducible protein PhoH
I6G32_RS08900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G32_RS08905	COG4535	Mg2 and Co2 transporter CorC
I6G32_RS08910	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G32_RS08925	COG0495	leucyl-tRNA aminoacylation
I6G32_RS08940	COG3036	rescue of stalled ribosome
I6G32_RS08945	COG2951	lytic endotransglycosylase activity
I6G32_RS08960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6G32_RS08965	COG0321	lipoyl(octanoyl) transferase activity
I6G32_RS08970	COG2921	Belongs to the UPF0250 family
I6G32_RS08975	COG1686	Belongs to the peptidase S11 family
I6G32_RS08985	COG2951	lytic endotransglycosylase activity
I6G32_RS08990	COG0772	Belongs to the SEDS family
I6G32_RS08995	COG0768	penicillin binding
I6G32_RS09000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G32_RS09010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G32_RS09015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G32_RS09020	COG0586	Pfam SNARE associated Golgi protein
I6G32_RS09030	COG1346	cytolysis
I6G32_RS09050	COG0702	epimerase
I6G32_RS09055	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6G32_RS09065	COG1162	GTPase activity
I6G32_RS09070	COG1360	Flagellar Motor Protein
I6G32_RS09075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G32_RS09090	COG0688	phosphatidylethanolamine metabolic process
I6G32_RS09100	COG2200	EAL domain
I6G32_RS09105	COG1063	alcohol dehydrogenase
I6G32_RS09110	COG3830	Belongs to the UPF0237 family
I6G32_RS09110	COG0560	Phosphoserine phosphatase
I6G32_RS09145	COG3150	esterase
I6G32_RS09150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G32_RS09160	COG0494	nUDIX hydrolase
I6G32_RS09170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6G32_RS09175	COG1538	Outer membrane efflux protein
I6G32_RS09180	COG1519	Transferase
I6G32_RS09195	COG0667	Aldo Keto reductase
I6G32_RS09205	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G32_RS09205	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G32_RS09220	COG1132	(ABC) transporter
I6G32_RS09250	COG0515	serine threonine protein kinase
I6G32_RS09255	COG0438	transferase activity, transferring glycosyl groups
I6G32_RS09260	COG2192	nodulation
I6G32_RS09285	COG0438	transferase activity, transferring glycosyl groups
I6G32_RS09290	COG0859	PFAM glycosyl transferase family 9
I6G32_RS09295	COG0859	PFAM glycosyl transferase family 9
I6G32_RS09305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G32_RS09330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G32_RS09335	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS09340	COG3706	GGDEF domain
I6G32_RS09345	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS09365	COG1073	alpha beta
I6G32_RS09365	COG2226	methyltransferase
I6G32_RS09370	COG0156	8-amino-7-oxononanoate synthase activity
I6G32_RS09375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G32_RS09380	COG1040	competence protein
I6G32_RS09385	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G32_RS09390	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G32_RS09425	COG1304	FMN binding
I6G32_RS09435	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS09440	COG3263	regulation of cellular component size
I6G32_RS09445	COG3264	Mechanosensitive ion channel
I6G32_RS09445	COG1196	nuclear chromosome segregation
I6G32_RS09450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6G32_RS09455	COG5002	protein histidine kinase activity
I6G32_RS09465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G32_RS09470	COG2205	protein histidine kinase activity
I6G32_RS09470	COG2198	Histidine kinase
I6G32_RS09470	COG0784	Response regulator, receiver
I6G32_RS09500	COG0330	HflC and HflK could
I6G32_RS09520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G32_RS09530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G32_RS09600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G32_RS09615	COG0513	Belongs to the DEAD box helicase family
I6G32_RS09620	COG1289	transmembrane transporter activity
I6G32_RS09630	COG2081	HI0933 family
I6G32_RS09670	COG0191	fructose-bisphosphate aldolase activity
I6G32_RS09685	COG0126	phosphoglycerate kinase activity
I6G32_RS09690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G32_RS09695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G32_RS09700	COG0583	DNA-binding transcription factor activity
I6G32_RS09705	COG2175	clavaminate synthase activity
I6G32_RS09715	COG2226	methyltransferase
I6G32_RS09720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G32_RS09730	COG0842	Transport permease protein
I6G32_RS09735	COG1131	(ABC) transporter
I6G32_RS09740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G32_RS09745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G32_RS09765	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6G32_RS09770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G32_RS09775	COG0513	Belongs to the DEAD box helicase family
I6G32_RS09790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G32_RS09795	COG2353	YceI-like domain
I6G32_RS09800	COG3038	cytochrome b561
I6G32_RS09810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G32_RS09820	COG2201	protein-glutamate methylesterase activity
I6G32_RS09825	COG2198	Histidine kinase
I6G32_RS09825	COG0784	Response regulator, receiver
I6G32_RS09825	COG0643	Histidine kinase
I6G32_RS09865	COG1678	Uncharacterized ACR, COG1678
I6G32_RS09880	COG0540	Belongs to the ATCase OTCase family
I6G32_RS09935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G32_RS09940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G32_RS09940	COG2813	Specifically methylates the guanine in position
I6G32_RS09950	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G32_RS09955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G32_RS09970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G32_RS09975	COG2022	thiamine diphosphate biosynthetic process
I6G32_RS09980	COG2022	thiamine diphosphate biosynthetic process
I6G32_RS09980	COG2104	thiamine diphosphate biosynthetic process
I6G32_RS09985	COG2363	Small membrane protein
I6G32_RS09990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G32_RS10010	COG2177	Part of the ABC transporter FtsEX involved in
I6G32_RS10015	COG2884	Cell division ATP-binding protein ftsE
I6G32_RS10020	COG0552	protein localization to endoplasmic reticulum
I6G32_RS10025	COG0612	Peptidase, M16
I6G32_RS10030	COG0612	Peptidase, M16
I6G32_RS10035	COG0742	ribosomal rna small subunit methyltransferase
I6G32_RS10050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G32_RS10085	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6G32_RS10090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G32_RS10095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G32_RS10115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G32_RS10125	COG0693	protein deglycase activity
I6G32_RS10140	COG0129	dihydroxy-acid dehydratase activity
I6G32_RS10145	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6G32_RS10170	COG0584	glycerophosphoryl diester phosphodiesterase
I6G32_RS10180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G32_RS10195	COG0704	Plays a role in the regulation of phosphate uptake
I6G32_RS10200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G32_RS10205	COG0573	inorganic phosphate transmembrane transporter activity
I6G32_RS10220	COG1607	acyl-coa hydrolase
I6G32_RS10225	COG4251	negative regulation of phosphorylation
I6G32_RS10225	COG5001	Diguanylate cyclase
I6G32_RS10225	COG2203	Gaf domain
I6G32_RS10225	COG3706	GGDEF domain
I6G32_RS10240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G32_RS10245	COG1074	ATP-dependent DNA helicase activity
I6G32_RS10250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G32_RS10265	COG3180	Ammonia monooxygenase
I6G32_RS10300	COG2203	Gaf domain
I6G32_RS10300	COG3706	GGDEF domain
I6G32_RS10300	COG4251	negative regulation of phosphorylation
I6G32_RS10300	COG5001	Diguanylate cyclase
I6G32_RS10320	COG2358	TRAP transporter, solute receptor (TAXI family
I6G32_RS10330	COG0700	Nucleoside recognition
I6G32_RS10350	COG2204	response regulator
I6G32_RS10355	COG5002	protein histidine kinase activity
I6G32_RS10365	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G32_RS10390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6G32_RS10395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G32_RS10395	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G32_RS10410	COG1178	ABC-type Fe3 transport system permease component
I6G32_RS10420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G32_RS10430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G32_RS10435	COG0006	proline dipeptidase activity
I6G32_RS10440	COG3079	Belongs to the UPF0149 family
I6G32_RS10460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G32_RS10485	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6G32_RS10495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G32_RS10500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6G32_RS10505	COG4942	peptidase
I6G32_RS10510	COG0793	Belongs to the peptidase S41A family
I6G32_RS10515	COG2861	carbohydrate metabolic process
I6G32_RS10530	COG0107	imidazoleglycerol-phosphate synthase activity
I6G32_RS10535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6G32_RS10550	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G32_RS10555	COG3707	response regulator
I6G32_RS10565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G32_RS10575	COG1116	anion transmembrane transporter activity
I6G32_RS10590	COG1194	a g-specific adenine glycosylase
I6G32_RS10595	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6G32_RS10605	COG1525	nuclease
I6G32_RS10640	COG0676	glucose-6-phosphate 1-epimerase activity
I6G32_RS10695	COG2204	response regulator
I6G32_RS10730	COG0840	transmembrane signaling receptor activity
I6G32_RS10745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G32_RS10765	COG3052	prosthetic group binding
I6G32_RS10770	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6G32_RS10780	COG4221	oxidoreductase activity
I6G32_RS10785	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6G32_RS10800	COG2358	TRAP transporter, solute receptor (TAXI family
I6G32_RS10840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G32_RS10850	COG3360	Dodecin
I6G32_RS10855	COG0625	glutathione transferase activity
I6G32_RS10875	COG0737	Belongs to the 5'-nucleotidase family
I6G32_RS10875	COG1525	nuclease
I6G32_RS10875	COG4085	toxin activity
I6G32_RS10890	COG3340	Belongs to the peptidase S51 family
I6G32_RS10895	COG1132	(ABC) transporter
I6G32_RS10910	COG3039	Transposase
I6G32_RS10920	COG2323	membrane
I6G32_RS10925	COG0583	DNA-binding transcription factor activity
I6G32_RS10960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G32_RS10965	COG0339	signal peptide processing
I6G32_RS11000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G32_RS11005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G32_RS11010	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I6G32_RS11040	COG0109	protoheme IX farnesyltransferase activity
I6G32_RS11065	COG1595	DNA-templated transcription, initiation
I6G32_RS11080	COG0523	cobalamin synthesis protein
I6G32_RS11095	COG4251	negative regulation of phosphorylation
I6G32_RS11100	COG0784	Response regulator, receiver
I6G32_RS11115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G32_RS11120	COG0501	Belongs to the peptidase M48B family
I6G32_RS11150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G32_RS11160	COG0542	response to heat
I6G32_RS11165	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G32_RS11220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G32_RS11225	COG1349	DNA-binding transcription factor activity
I6G32_RS11235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G32_RS11240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6G32_RS11245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G32_RS11250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G32_RS11255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6G32_RS11260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G32_RS11265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G32_RS11275	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G32_RS11280	COG3312	ion transport
I6G32_RS11285	COG1475	DNA binding
I6G32_RS11290	COG1192	Involved in chromosome partitioning
I6G32_RS11295	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G32_RS11300	COG0445	tRNA wobble uridine modification
I6G32_RS11305	COG1320	monovalent cation:proton antiporter activity
I6G32_RS11320	COG0651	ATP synthesis coupled electron transport
I6G32_RS11325	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G32_RS11330	COG2111	Na H antiporter
I6G32_RS11335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G32_RS11335	COG2111	Na H antiporter
I6G32_RS11340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G32_RS11345	COG0706	membrane insertase activity
I6G32_RS11350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G32_RS11355	COG0594	ribonuclease P activity
I6G32_RS11360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G32_RS11365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G32_RS11375	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G32_RS11420	COG3706	GGDEF domain
I6G32_RS11435	COG0751	glycine-tRNA ligase activity
I6G32_RS11445	COG2818	Glycosylase
I6G32_RS11465	COG1126	abc transporter atp-binding protein
I6G32_RS11470	COG0765	amino acid transport
I6G32_RS11475	COG0765	amino acid transport
I6G32_RS11480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G32_RS11485	COG0569	domain protein
I6G32_RS11490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G32_RS11495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G32_RS11500	COG0242	peptide deformylase activity
I6G32_RS11510	COG0758	DNA mediated transformation
I6G32_RS11515	COG0009	L-threonylcarbamoyladenylate synthase
I6G32_RS11525	COG0408	coproporphyrinogen oxidase activity
I6G32_RS11530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G32_RS11545	COG1686	Belongs to the peptidase S11 family
I6G32_RS11585	COG2011	ABC-type metal ion transport system permease component
I6G32_RS11600	COG1451	nucleotide metabolic process
I6G32_RS11605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G32_RS11610	COG1121	(ABC) transporter
I6G32_RS11615	COG0735	belongs to the Fur family
I6G32_RS11625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G32_RS11630	COG1012	belongs to the aldehyde dehydrogenase family
I6G32_RS11650	COG0745	RESPONSE REGULATOR receiver
I6G32_RS11655	COG5002	protein histidine kinase activity
I6G32_RS11665	COG0745	RESPONSE REGULATOR receiver
I6G32_RS11670	COG5002	protein histidine kinase activity
I6G32_RS11675	COG0745	RESPONSE REGULATOR receiver
I6G32_RS11680	COG4191	Histidine kinase
I6G32_RS11690	COG3706	GGDEF domain
I6G32_RS11700	COG2957	Belongs to the agmatine deiminase family
I6G32_RS11715	COG0174	glutamine synthetase
I6G32_RS11720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G32_RS11725	COG0174	glutamine synthetase
I6G32_RS11750	COG3842	ATPase activity
I6G32_RS11755	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G32_RS11760	COG1177	transmembrane transport
I6G32_RS11830	COG0842	Transport permease protein
I6G32_RS11835	COG0842	Transport permease protein
I6G32_RS11835	COG1129	ABC transporter
I6G32_RS11840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G32_RS11855	COG1127	ABC transporter
I6G32_RS11860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G32_RS11865	COG0753	catalase activity
I6G32_RS11870	COG2010	Cytochrome c
I6G32_RS11905	COG0515	serine threonine protein kinase
I6G32_RS11945	COG3039	Transposase
I6G32_RS11955	COG0583	DNA-binding transcription factor activity
I6G32_RS11965	COG0765	amino acid transport
I6G32_RS11970	COG0765	amino acid transport
I6G32_RS11975	COG4598	ABC transporter
I6G32_RS12040	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G32_RS12045	COG1160	GTP binding
I6G32_RS12055	COG3039	Transposase
I6G32_RS12075	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6G32_RS12080	COG3909	cytochrome
I6G32_RS12085	COG1012	belongs to the aldehyde dehydrogenase family
I6G32_RS12095	COG1024	Enoyl-CoA hydratase
I6G32_RS12095	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G32_RS12100	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS12105	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS12110	COG2814	Major facilitator Superfamily
I6G32_RS12130	COG0318	PFAM AMP-dependent synthetase and ligase
I6G32_RS12135	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G32_RS12140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G32_RS12155	COG1611	Belongs to the LOG family
I6G32_RS12225	COG2207	Transcriptional regulator
I6G32_RS12235	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G32_RS12305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G32_RS12310	COG0583	DNA-binding transcription factor activity
I6G32_RS12350	COG2706	6-phosphogluconolactonase activity
I6G32_RS12355	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS12360	COG0784	Response regulator, receiver
I6G32_RS12360	COG4191	Histidine kinase
I6G32_RS12385	COG3795	YCII-related domain
I6G32_RS12390	COG4941	Belongs to the sigma-70 factor family
I6G32_RS12395	COG2204	response regulator
I6G32_RS12400	COG4191	Histidine kinase
I6G32_RS12410	COG0589	response to stress
I6G32_RS12415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G32_RS12450	COG3276	selenocysteine insertion sequence binding
I6G32_RS12455	COG1921	L-seryl-tRNASec selenium transferase activity
I6G32_RS12460	COG3058	Necessary for formate dehydrogenase activity
I6G32_RS12465	COG2864	formate dehydrogenase
I6G32_RS12470	COG0437	4 iron, 4 sulfur cluster binding
I6G32_RS12485	COG1764	response to oxidative stress
I6G32_RS12500	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6G32_RS12505	COG0210	DNA helicase
I6G32_RS12515	COG0826	peptidase U32
I6G32_RS12520	COG2841	Protein conserved in bacteria
I6G32_RS12525	COG0527	aspartate kinase activity
I6G32_RS12530	COG5285	phytanoyl-CoA dioxygenase
I6G32_RS12535	COG1917	Cupin 2, conserved barrel domain protein
I6G32_RS12540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G32_RS12550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G32_RS12555	COG0837	glucose binding
I6G32_RS12555	COG1737	Transcriptional regulator
I6G32_RS12565	COG0583	DNA-binding transcription factor activity
I6G32_RS12570	COG0439	Biotin carboxylase
I6G32_RS12575	COG0511	ligase activity, forming carbon-carbon bonds
I6G32_RS12575	COG5016	pyruvate
I6G32_RS12590	COG2066	Belongs to the glutaminase family
I6G32_RS12605	COG0252	asparaginase activity
I6G32_RS12610	COG1115	amino acid carrier protein
I6G32_RS12630	COG0583	DNA-binding transcription factor activity
I6G32_RS12640	COG1082	Xylose isomerase domain protein TIM barrel
I6G32_RS12640	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6G32_RS12645	COG2205	protein histidine kinase activity
I6G32_RS12675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G32_RS12685	COG4208	sulfate ABC transporter
I6G32_RS12695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G32_RS12700	COG5583	Uncharacterized small protein (DUF2292)
I6G32_RS12710	COG0450	alkyl hydroperoxide reductase
I6G32_RS12730	COG1715	Restriction endonuclease
I6G32_RS12760	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6G32_RS12785	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6G32_RS12790	COG1764	response to oxidative stress
I6G32_RS12805	COG2989	Protein conserved in bacteria
I6G32_RS12815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G32_RS12825	COG1392	Phosphate transport regulator
I6G32_RS12830	COG0306	phosphate transporter
I6G32_RS12845	COG2918	glutathione biosynthetic process
I6G32_RS12855	COG2183	response to ionizing radiation
I6G32_RS12860	COG0457	Tetratricopeptide repeat
I6G32_RS12860	COG3118	belongs to the thioredoxin family
I6G32_RS12865	COG1215	transferase activity, transferring glycosyl groups
I6G32_RS12870	COG1215	transferase activity, transferring glycosyl groups
I6G32_RS12875	COG1192	Involved in chromosome partitioning
I6G32_RS12915	COG0189	ligase activity
I6G32_RS12920	COG0189	ligase activity
I6G32_RS12920	COG4067	protein conserved in archaea
I6G32_RS12925	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G32_RS12935	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G32_RS12945	COG0778	Nitroreductase
I6G32_RS12955	COG0514	ATP-dependent DNA helicase (RecQ)
I6G32_RS12960	COG0840	transmembrane signaling receptor activity
I6G32_RS12970	COG0840	transmembrane signaling receptor activity
I6G32_RS12975	COG0667	Aldo Keto reductase
I6G32_RS13005	COG2205	protein histidine kinase activity
I6G32_RS13015	COG2172	sigma factor antagonist activity
I6G32_RS13020	COG1366	Belongs to the anti-sigma-factor antagonist family
I6G32_RS13025	COG1366	Belongs to the anti-sigma-factor antagonist family
I6G32_RS13035	COG1024	Enoyl-CoA hydratase
I6G32_RS13035	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G32_RS13040	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS13045	COG1454	alcohol dehydrogenase
I6G32_RS13060	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G32_RS13070	COG1011	Hydrolase
I6G32_RS13075	COG0494	nUDIX hydrolase
I6G32_RS13080	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6G32_RS13095	COG0058	SHG alpha-glucan phosphorylase activity
I6G32_RS13100	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6G32_RS13130	COG1490	D-aminoacyl-tRNA deacylase activity
I6G32_RS13150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G32_RS13155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G32_RS13160	COG0140	phosphoribosyl-ATP diphosphatase activity
I6G32_RS13165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G32_RS13170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G32_RS13180	COG2226	methyltransferase
I6G32_RS13190	COG0840	transmembrane signaling receptor activity
I6G32_RS13200	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6G32_RS13210	COG0243	molybdopterin cofactor binding
I6G32_RS13230	COG3852	Histidine kinase
I6G32_RS13250	COG0301	tRNA thio-modification
I6G32_RS13250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G32_RS13255	COG1217	gtp-binding protein TYPA
I6G32_RS13265	COG3493	citrate carrier protein
I6G32_RS13270	COG3290	protein histidine kinase activity
I6G32_RS13275	COG4565	transcriptional regulatory protein
I6G32_RS13300	COG2204	response regulator
I6G32_RS13305	COG4807	Protein conserved in bacteria
I6G32_RS13330	COG5001	Diguanylate cyclase
I6G32_RS13335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G32_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS13365	COG1966	Carbon starvation protein
I6G32_RS13380	COG1320	monovalent cation:proton antiporter activity
I6G32_RS13400	COG0651	ATP synthesis coupled electron transport
I6G32_RS13405	COG0651	ATP synthesis coupled electron transport
I6G32_RS13445	COG2197	response regulator
I6G32_RS13470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G32_RS13475	COG0277	FAD linked oxidase domain protein
I6G32_RS13480	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G32_RS13500	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6G32_RS13505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G32_RS13525	COG0494	nUDIX hydrolase
I6G32_RS13540	COG0730	response to heat
I6G32_RS13545	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G32_RS13550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6G32_RS13555	COG1192	Involved in chromosome partitioning
I6G32_RS13565	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G32_RS13575	COG0411	ABC transporter
I6G32_RS13595	COG0739	heme binding
I6G32_RS13605	COG1253	flavin adenine dinucleotide binding
I6G32_RS13620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6G32_RS13625	COG3161	chorismate lyase activity
I6G32_RS13630	COG2186	Transcriptional regulator
I6G32_RS13635	COG0277	FAD linked oxidase domain protein
I6G32_RS13640	COG0277	FAD linked oxidase domain protein
I6G32_RS13645	COG0247	lactate metabolic process
I6G32_RS13650	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6G32_RS13655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G32_RS13660	COG1620	l-lactate permease
I6G32_RS13685	COG0583	DNA-binding transcription factor activity
I6G32_RS13690	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS13700	COG0604	alcohol dehydrogenase
I6G32_RS13705	COG0583	DNA-binding transcription factor activity
I6G32_RS13710	COG1704	LemA family
I6G32_RS13715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6G32_RS13735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G32_RS13755	COG2080	2 iron, 2 sulfur cluster binding
I6G32_RS13775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G32_RS13780	COG1758	RNA polymerase activity
I6G32_RS13790	COG1561	YicC-like family, N-terminal region
I6G32_RS13810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6G32_RS13820	COG0708	Exodeoxyribonuclease III
I6G32_RS13825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G32_RS13840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G32_RS13850	COG0756	dUTP diphosphatase activity
I6G32_RS13855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G32_RS13860	COG2003	Belongs to the UPF0758 family
I6G32_RS13875	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G32_RS13895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G32_RS13900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G32_RS13910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G32_RS13915	COG0251	oxidation-reduction process
I6G32_RS13935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G32_RS13950	COG0366	Alpha amylase catalytic
I6G32_RS13955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G32_RS13965	COG1454	alcohol dehydrogenase
I6G32_RS13975	COG1414	Transcriptional regulator
I6G32_RS13980	COG1272	protein, Hemolysin III
I6G32_RS13985	COG0210	DNA helicase
I6G32_RS13995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G32_RS14000	COG0606	chelatase, subunit chli
I6G32_RS14010	COG0347	Belongs to the P(II) protein family
I6G32_RS14015	COG0004	ammonium transporteR
I6G32_RS14020	COG0004	ammonium transporteR
I6G32_RS14025	COG0432	Pfam Uncharacterised protein family UPF0047
I6G32_RS14040	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6G32_RS14050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6G32_RS14065	COG1965	Belongs to the frataxin family
I6G32_RS14070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G32_RS14105	COG0165	Argininosuccinate lyase
I6G32_RS14110	COG3275	phosphorelay sensor kinase activity
I6G32_RS14120	COG0181	hydroxymethylbilane synthase activity
I6G32_RS14140	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G32_RS14160	COG0488	(ABC) transporter
I6G32_RS14170	COG0861	Integral membrane protein TerC family
I6G32_RS14175	COG1280	lysine exporter protein (LysE YggA)
I6G32_RS14180	COG1671	Belongs to the UPF0178 family
I6G32_RS14195	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6G32_RS14205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G32_RS14210	COG0248	Ppx GppA phosphatase
I6G32_RS14225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6G32_RS14240	COG0018	arginyl-trna synthetase
I6G32_RS14245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G32_RS14250	COG0254	rRNA binding
I6G32_RS14260	COG0281	malic enzyme
I6G32_RS14295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G32_RS14300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6G32_RS14310	COG0069	glutamate synthase activity
I6G32_RS14310	COG0067	glutamate synthase
I6G32_RS14310	COG0070	glutamate synthase
I6G32_RS14315	COG0493	'glutamate synthase
I6G32_RS14325	COG2814	Major facilitator Superfamily
I6G32_RS14330	COG0583	DNA-binding transcription factor activity
I6G32_RS14340	COG3118	belongs to the thioredoxin family
I6G32_RS14345	COG2873	o-acetylhomoserine
I6G32_RS14350	COG0471	metal ion transport
I6G32_RS14350	COG3273	potassium ion transport
I6G32_RS14360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G32_RS14365	COG0358	DNA primase activity
I6G32_RS14370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G32_RS14375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G32_RS14380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6G32_RS14395	COG0617	tRNA 3'-terminal CCA addition
I6G32_RS14400	COG2719	SpoVR family
I6G32_RS14405	COG2718	Belongs to the UPF0229 family
I6G32_RS14410	COG2766	serine protein kinase
I6G32_RS14415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G32_RS14420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G32_RS14425	COG2967	ApaG domain
I6G32_RS14430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G32_RS14435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G32_RS14440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G32_RS14445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6G32_RS14455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6G32_RS14475	COG2197	response regulator
I6G32_RS14480	COG3842	ATPase activity
I6G32_RS14490	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G32_RS14495	COG1177	transmembrane transport
I6G32_RS14505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G32_RS14510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G32_RS14515	COG0546	phosphoglycolate phosphatase activity
I6G32_RS14525	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G32_RS14530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G32_RS14535	COG0134	indole-3-glycerol-phosphate synthase activity
I6G32_RS14545	COG1765	OsmC-like protein
I6G32_RS14550	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6G32_RS14555	COG0537	adenosine 5'-monophosphoramidase activity
I6G32_RS14560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G32_RS14570	COG1981	membrane
I6G32_RS14575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G32_RS14580	COG0316	Belongs to the HesB IscA family
I6G32_RS14585	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6G32_RS14590	COG0739	heme binding
I6G32_RS14595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G32_RS14625	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6G32_RS14625	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6G32_RS14630	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6G32_RS14655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G32_RS14675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G32_RS14680	COG0081	regulation of translation
I6G32_RS14685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G32_RS14690	COG0222	ribosome binding
I6G32_RS14695	COG0085	RNA polymerase activity
I6G32_RS14700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G32_RS14705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G32_RS14710	COG0049	tRNA binding
I6G32_RS14715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G32_RS14720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G32_RS14725	COG0051	transcription antitermination factor activity, RNA binding
I6G32_RS14730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G32_RS14735	COG0088	Forms part of the polypeptide exit tunnel
I6G32_RS14740	COG0089	rRNA binding
I6G32_RS14745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G32_RS14750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G32_RS14755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G32_RS14760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6G32_RS14765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G32_RS14770	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G32_RS14775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G32_RS14780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G32_RS14785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G32_RS14790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G32_RS14795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G32_RS14800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G32_RS14805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G32_RS14815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G32_RS14820	COG1841	ribosomal large subunit assembly
I6G32_RS14825	COG0200	Binds to the 23S rRNA
I6G32_RS14835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G32_RS14840	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G32_RS14845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G32_RS14850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G32_RS14855	COG0202	RNA polymerase activity
I6G32_RS14860	COG0203	ribosomal protein L17
I6G32_RS14875	COG2814	Major facilitator Superfamily
I6G32_RS14895	COG3047	cAMP biosynthetic process
I6G32_RS14905	COG0811	peptide transport
I6G32_RS14910	COG0811	peptide transport
I6G32_RS14915	COG0848	biopolymer transport protein
I6G32_RS14940	COG4181	ATPase activity
I6G32_RS14955	COG3118	belongs to the thioredoxin family
I6G32_RS14960	COG2391	methyltransferase activity
I6G32_RS14965	COG0425	Belongs to the sulfur carrier protein TusA family
I6G32_RS14975	COG2264	protein methyltransferase activity
I6G32_RS14990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G32_RS14990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G32_RS15005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G32_RS15010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G32_RS15015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6G32_RS15020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G32_RS15025	COG3577	Aspartyl protease
I6G32_RS15030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G32_RS15055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G32_RS15065	COG4206	TonB-dependent receptor
I6G32_RS15075	COG0420	3'-5' exonuclease activity
I6G32_RS15120	COG0564	pseudouridine synthase activity
I6G32_RS15130	COG1040	competence protein
I6G32_RS15135	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS15140	COG2610	gluconate transmembrane transporter activity
I6G32_RS15145	COG2031	fatty acid transporter
I6G32_RS15155	COG1522	sequence-specific DNA binding
I6G32_RS15170	COG0733	neurotransmitter:sodium symporter activity
I6G32_RS15180	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6G32_RS15190	COG0625	glutathione transferase activity
I6G32_RS15195	COG0733	neurotransmitter:sodium symporter activity
I6G32_RS15215	COG0513	Belongs to the DEAD box helicase family
I6G32_RS15245	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6G32_RS15255	COG1946	Acyl-CoA thioesterase
I6G32_RS15265	COG2321	neutral zinc metallopeptidase
I6G32_RS15290	COG2197	response regulator
I6G32_RS15295	COG3850	Histidine kinase
I6G32_RS15300	COG2223	nitrite transmembrane transporter activity
I6G32_RS15310	COG2223	nitrite transmembrane transporter activity
I6G32_RS15315	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G32_RS15320	COG1140	nitrate reductase beta subunit
I6G32_RS15325	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G32_RS15330	COG2181	nitrate reductase activity
I6G32_RS15345	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G32_RS15355	COG3038	cytochrome b561
I6G32_RS15405	COG0642	Histidine kinase
I6G32_RS15415	COG3642	lipopolysaccharide core region biosynthetic process
I6G32_RS15425	COG1368	sulfuric ester hydrolase activity
I6G32_RS15430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G32_RS15435	COG2252	PERMEase
I6G32_RS15445	COG3608	succinylglutamate desuccinylase aspartoacylase
I6G32_RS15445	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6G32_RS15450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G32_RS15455	COG2080	2 iron, 2 sulfur cluster binding
I6G32_RS15460	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G32_RS15465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G32_RS15490	COG0789	Transcriptional regulator
I6G32_RS15495	COG2813	Specifically methylates the guanine in position
I6G32_RS15530	COG0488	(ABC) transporter
I6G32_RS15535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6G32_RS15540	COG2020	methyltransferase activity
I6G32_RS15565	COG1970	mechanosensitive ion channel activity
I6G32_RS15575	COG0714	Associated with various cellular activities
I6G32_RS15580	COG3256	nitric oxide reductase
I6G32_RS15585	COG2010	Cytochrome c
I6G32_RS15605	COG1067	ATP-dependent peptidase activity
I6G32_RS15615	COG2862	Uncharacterized protein family, UPF0114
I6G32_RS15625	COG3046	protein related to deoxyribodipyrimidine photolyase
I6G32_RS15635	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G32_RS15645	COG0142	geranyltranstransferase activity
I6G32_RS15650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G32_RS15655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G32_RS15660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6G32_RS15665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G32_RS15670	COG3045	CreA protein
I6G32_RS15675	COG0268	Binds directly to 16S ribosomal RNA
I6G32_RS15685	COG0196	riboflavin kinase activity
I6G32_RS15690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G32_RS15695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G32_RS15700	COG1047	Peptidyl-prolyl cis-trans
I6G32_RS15705	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G32_RS15740	COG4968	Prepilin-type N-terminal cleavage methylation domain
I6G32_RS15745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G32_RS15750	COG0023	Translation Initiation Factor
I6G32_RS15765	COG0534	Mate efflux family protein
I6G32_RS15795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G32_RS15810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G32_RS15810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G32_RS15815	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G32_RS15820	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6G32_RS15820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G32_RS15820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G32_RS15825	COG4993	Dehydrogenase
I6G32_RS15830	COG2852	Protein conserved in bacteria
I6G32_RS15835	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G32_RS15840	COG0019	diaminopimelate decarboxylase activity
I6G32_RS15850	COG3128	pkhd-type hydroxylase
I6G32_RS15855	COG4774	siderophore transport
I6G32_RS15860	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G32_RS15880	COG4771	TonB-dependent receptor
I6G32_RS15895	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6G32_RS15905	COG0739	heme binding
I6G32_RS15920	COG0530	calcium, potassium:sodium antiporter activity
I6G32_RS15935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G32_RS15945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G32_RS15950	COG1077	Cell shape determining protein MreB Mrl
I6G32_RS15955	COG1792	Involved in formation and maintenance of cell shape
I6G32_RS15975	COG1530	ribonuclease E activity
I6G32_RS15985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G32_RS15990	COG0312	modulator of DNA gyrase
I6G32_RS16000	COG0312	modulator of DNA gyrase
I6G32_RS16005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G32_RS16010	COG1660	Displays ATPase and GTPase activities
I6G32_RS16025	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G32_RS16030	COG1137	ATPase activity
I6G32_RS16045	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G32_RS16055	COG1127	ABC transporter
I6G32_RS16060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G32_RS16065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G32_RS16090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G32_RS16095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G32_RS16105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G32_RS16110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G32_RS16120	COG0175	sulfate reduction
I6G32_RS16130	COG1943	Transposase
I6G32_RS16155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6G32_RS16160	COG0237	dephospho-CoA kinase activity
I6G32_RS16175	COG0667	Aldo Keto reductase
I6G32_RS16180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G32_RS16185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G32_RS16195	COG0723	plastoquinol--plastocyanin reductase activity
I6G32_RS16200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G32_RS16205	COG2857	Cytochrome c1
I6G32_RS16210	COG0625	glutathione transferase activity
I6G32_RS16215	COG2969	positive regulation of protein catabolic process
I6G32_RS16220	COG2823	Periplasmic or secreted lipoprotein
I6G32_RS16225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G32_RS16230	COG0792	nuclease activity
I6G32_RS16255	COG0275	rRNA processing
I6G32_RS16270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G32_RS16275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G32_RS16280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G32_RS16285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G32_RS16290	COG0772	Belongs to the SEDS family
I6G32_RS16295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G32_RS16300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G32_RS16305	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G32_RS16355	COG1285	pathogenesis
I6G32_RS16380	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS16385	COG0659	secondary active sulfate transmembrane transporter activity
I6G32_RS16440	COG0840	transmembrane signaling receptor activity
I6G32_RS16445	COG0501	Belongs to the peptidase M48B family
I6G32_RS16455	COG2119	membrane
I6G32_RS16460	COG2813	Specifically methylates the guanine in position
I6G32_RS16465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G32_RS16470	COG1280	lysine exporter protein (LysE YggA)
I6G32_RS16475	COG0318	PFAM AMP-dependent synthetase and ligase
I6G32_RS16485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G32_RS16490	COG2885	chlorophyll binding
I6G32_RS16495	COG0784	Response regulator, receiver
I6G32_RS16495	COG2205	protein histidine kinase activity
I6G32_RS16505	COG0204	Acyl-transferase
I6G32_RS16515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G32_RS16525	COG0386	Belongs to the glutathione peroxidase family
I6G32_RS16530	COG1309	transcriptional regulator
I6G32_RS16540	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
I6G32_RS16555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G32_RS16560	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS16600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G32_RS16605	COG0693	protein deglycase activity
I6G32_RS16610	COG4628	conserved protein (DUF2132)
I6G32_RS16630	COG0469	pyruvate kinase activity
I6G32_RS16655	COG0714	Associated with various cellular activities
I6G32_RS16680	COG2925	Exonuclease
I6G32_RS16690	COG0788	formyltetrahydrofolate deformylase activity
I6G32_RS16700	COG0433	COG0433 Predicted ATPase
I6G32_RS16715	COG3022	response to hydroperoxide
I6G32_RS16725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6G32_RS16730	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G32_RS16735	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G32_RS16755	COG0400	carboxylic ester hydrolase activity
I6G32_RS16760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G32_RS16765	COG4597	amino acid ABC transporter
I6G32_RS16770	COG0765	amino acid transport
I6G32_RS16775	COG1126	abc transporter atp-binding protein
I6G32_RS16780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G32_RS16780	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G32_RS16790	COG3034	peptidoglycan biosynthetic process
I6G32_RS16800	COG0494	nUDIX hydrolase
I6G32_RS16815	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6G32_RS16820	COG4536	flavin adenine dinucleotide binding
I6G32_RS16825	COG4137	Cytochrome C assembly protein
I6G32_RS16830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G32_RS16835	COG0228	four-way junction DNA binding
I6G32_RS16840	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G32_RS16845	COG0336	Belongs to the RNA methyltransferase TrmD family
I6G32_RS16850	COG0335	large ribosomal subunit rRNA binding
I6G32_RS16865	COG3791	Glutathione-dependent formaldehyde-activating
I6G32_RS16880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G32_RS16885	COG0418	dihydroorotase activity
I6G32_RS16895	COG0137	argininosuccinate synthase activity
I6G32_RS16900	COG0346	lactoylglutathione lyase activity
I6G32_RS16910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G32_RS16920	COG4659	FMN binding
I6G32_RS16925	COG4658	electron transport chain
I6G32_RS16935	COG2878	Part of a membrane complex involved in electron transport
I6G32_RS16940	COG4657	Part of a membrane complex involved in electron transport
I6G32_RS16955	COG1024	Enoyl-CoA hydratase
I6G32_RS16965	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G32_RS16980	COG0354	folic acid binding
I6G32_RS17020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G32_RS17025	COG0481	GTPase activity
I6G32_RS17040	COG0571	ribonuclease III activity
I6G32_RS17050	COG1381	Involved in DNA repair and RecF pathway recombination
I6G32_RS17055	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G32_RS17065	COG0583	DNA-binding transcription factor activity
I6G32_RS17075	COG0500	methyltransferase
I6G32_RS17080	COG2226	methyltransferase
I6G32_RS17090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G32_RS17105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G32_RS17120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G32_RS17135	COG3485	protocatechuate 3,4-dioxygenase
I6G32_RS17140	COG3485	protocatechuate 3,4-dioxygenase
I6G32_RS17145	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G32_RS17155	COG1414	Transcriptional regulator
I6G32_RS17160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G32_RS17165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G32_RS17180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G32_RS17185	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G32_RS17190	COG0583	DNA-binding transcription factor activity
I6G32_RS17200	COG0583	DNA-binding transcription factor activity
I6G32_RS17215	COG1192	Involved in chromosome partitioning
I6G32_RS17240	COG3077	Addiction module antitoxin, RelB DinJ family
I6G32_RS17380	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6G32_RS17390	COG0464	growth
I6G32_RS17395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G32_RS17455	COG2003	Belongs to the UPF0758 family
I6G32_RS17520	COG0789	Transcriptional regulator
I6G32_RS17530	COG2608	mercury ion transmembrane transporter activity
I6G32_RS17535	COG2608	mercury ion transmembrane transporter activity
I6G32_RS17540	COG0789	Transcriptional regulator
I6G32_RS17610	COG0582	viral genome integration into host DNA
I6G32_RS17630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G32_RS17630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G32_RS17635	COG0489	protein tyrosine kinase activity
I6G32_RS17640	COG1278	Cold shock
I6G32_RS17645	COG0717	Belongs to the dCTP deaminase family
I6G32_RS17650	COG3005	denitrification pathway
I6G32_RS17660	COG0243	molybdopterin cofactor binding
I6G32_RS17670	COG4459	periplasmic nitrate reductase
I6G32_RS17675	COG2814	Major facilitator Superfamily
I6G32_RS17700	COG0037	tRNA processing
I6G32_RS17705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G32_RS17710	COG2818	Glycosylase
I6G32_RS17735	COG1294	oxidase, subunit
I6G32_RS17740	COG4890	Cyd operon protein YbgT
I6G32_RS17755	COG0791	NLP P60 protein
I6G32_RS17760	COG0791	NLP P60 protein
I6G32_RS17775	COG4206	TonB-dependent receptor
I6G32_RS17790	COG1797	cobyrinic acid a,c-diamide synthase activity
I6G32_RS17795	COG0778	Nitroreductase
I6G32_RS17805	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6G32_RS17815	COG1492	cobalamin metabolic process
I6G32_RS17825	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6G32_RS17835	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6G32_RS17845	COG0251	oxidation-reduction process
I6G32_RS17870	COG2067	long-chain fatty acid transport protein
I6G32_RS17885	COG3100	YcgL domain-containing protein
I6G32_RS17895	COG2983	Belongs to the UPF0260 family
I6G32_RS17910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G32_RS17915	COG0527	aspartate kinase activity
I6G32_RS17920	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6G32_RS17945	COG2239	Acts as a magnesium transporter
I6G32_RS17950	COG3630	sodium ion export across plasma membrane
I6G32_RS17960	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6G32_RS17975	COG1484	DNA-dependent DNA replication
I6G32_RS17980	COG4584	PFAM Integrase catalytic
I6G32_RS17995	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6G32_RS18015	COG0835	chemotaxis
I6G32_RS18015	COG0784	Response regulator, receiver
I6G32_RS18020	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G32_RS18025	COG1815	bacterial-type flagellum-dependent cell motility
I6G32_RS18045	COG4787	bacterial-type flagellum-dependent cell motility
I6G32_RS18050	COG4786	Flagellar basal body rod
I6G32_RS18055	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6G32_RS18060	COG1706	bacterial-type flagellum-dependent cell motility
I6G32_RS18070	COG1256	bacterial-type flagellum assembly
I6G32_RS18080	COG1555	photosystem II stabilization
I6G32_RS18105	COG2200	EAL domain
I6G32_RS18120	COG1362	aminopeptidase activity
I6G32_RS18130	COG0564	pseudouridine synthase activity
I6G32_RS18135	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6G32_RS18140	COG2894	cell division
I6G32_RS18145	COG0850	regulation of cytokinetic process
I6G32_RS18150	COG1560	Kdo2-lipid A biosynthetic process
I6G32_RS18160	COG2853	Lipoprotein
I6G32_RS18175	COG3162	membrane
I6G32_RS18180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G32_RS18200	COG3089	Belongs to the UPF0270 family
I6G32_RS18210	COG1363	Peptidase, m42
I6G32_RS18215	COG0189	ligase activity
I6G32_RS18215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G32_RS18220	COG0367	asparagine synthase
I6G32_RS18230	COG1404	Belongs to the peptidase S8 family
I6G32_RS18230	COG4935	Belongs to the peptidase S8 family
I6G32_RS18240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6G32_RS18250	COG4221	oxidoreductase activity
I6G32_RS18305	COG4993	Dehydrogenase
I6G32_RS18310	COG2996	Protein conserved in bacteria
I6G32_RS18325	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I6G32_RS18390	COG1295	ribonuclease BN
I6G32_RS18395	COG0438	transferase activity, transferring glycosyl groups
I6G32_RS18415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6G32_RS18420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G32_RS18430	COG1546	Belongs to the CinA family
I6G32_RS18435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G32_RS18440	COG2137	regulation of response to DNA damage stimulus
I6G32_RS18450	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6G32_RS18455	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6G32_RS18465	COG3148	PFAM DTW domain containing protein
I6G32_RS18470	COG0697	spore germination
I6G32_RS18480	COG0583	DNA-binding transcription factor activity
I6G32_RS18490	COG3012	SEC-C Motif Domain Protein
I6G32_RS18510	COG1199	ATP-dependent helicase activity
I6G32_RS18515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G32_RS18525	COG0259	pyridoxamine-phosphate oxidase activity
I6G32_RS18540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G32_RS18540	COG2111	Na H antiporter
I6G32_RS18545	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G32_RS18550	COG0651	ATP synthesis coupled electron transport
I6G32_RS18560	COG2212	antiporter activity
I6G32_RS18565	COG1320	monovalent cation:proton antiporter activity
I6G32_RS18570	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6G32_RS18575	COG0024	Methionine aminopeptidase
I6G32_RS18580	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G32_RS18585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G32_RS18590	COG0528	UMP kinase activity
I6G32_RS18595	COG0233	cytoplasmic translational termination
I6G32_RS18600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G32_RS18610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6G32_RS18630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G32_RS18635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G32_RS18640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G32_RS18645	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G32_RS18650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G32_RS18660	COG0825	malonyl-CoA metabolic process
I6G32_RS18665	COG0037	tRNA processing
I6G32_RS18670	COG0504	CTP synthase activity
I6G32_RS18675	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6G32_RS18690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6G32_RS18705	COG0583	DNA-binding transcription factor activity
I6G32_RS18710	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6G32_RS18715	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6G32_RS18720	COG1902	pentaerythritol trinitrate reductase activity
I6G32_RS18730	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6G32_RS18735	COG0585	pseudouridine synthase activity
I6G32_RS18740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6G32_RS18745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6G32_RS18810	COG0217	transcriptional regulatory protein
I6G32_RS18820	COG2258	MOSC domain
I6G32_RS18835	COG0004	ammonium transporteR
I6G32_RS18840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G32_RS18885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G32_RS18890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G32_RS18900	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6G32_RS18915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G32_RS18935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G32_RS18955	COG2010	Cytochrome c
I6G32_RS18965	COG2814	Major facilitator Superfamily
I6G32_RS18970	COG0826	peptidase U32
I6G32_RS19000	COG0789	Transcriptional regulator
I6G32_RS19025	COG0583	DNA-binding transcription factor activity
I6G32_RS19050	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6G32_RS19055	COG2226	methyltransferase
I6G32_RS19065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6G32_RS19070	COG0583	DNA-binding transcription factor activity
I6G32_RS19085	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6G32_RS19090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G32_RS19100	COG0745	RESPONSE REGULATOR receiver
I6G32_RS19105	COG2205	protein histidine kinase activity
I6G32_RS19115	COG0668	transmembrane transport
I6G32_RS19160	COG2988	succinylglutamate desuccinylase activity
I6G32_RS19165	COG1131	(ABC) transporter
I6G32_RS19170	COG0842	Transport permease protein
I6G32_RS19175	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G32_RS19175	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G32_RS19185	COG2853	Lipoprotein
I6G32_RS19195	COG0745	RESPONSE REGULATOR receiver
I6G32_RS19205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G32_RS19225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G32_RS19260	COG2814	Major facilitator Superfamily
I6G32_RS19265	COG4948	Mandelate Racemase Muconate Lactonizing
I6G32_RS19270	COG4829	muconolactone delta-isomerase
I6G32_RS19275	COG3485	protocatechuate 3,4-dioxygenase
I6G32_RS19280	COG3135	benzoate transporter
I6G32_RS19320	COG4191	Histidine kinase
I6G32_RS19320	COG0784	Response regulator, receiver
I6G32_RS19330	COG0114	fumarate hydratase activity
I6G32_RS19340	COG0271	Belongs to the BolA IbaG family
I6G32_RS19345	COG1054	Belongs to the UPF0176 family
I6G32_RS19360	COG0840	transmembrane signaling receptor activity
I6G32_RS19385	COG0583	DNA-binding transcription factor activity
I6G32_RS19390	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6G32_RS19395	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS19405	COG2079	MmgE PrpD family protein
I6G32_RS19415	COG2301	Belongs to the HpcH HpaI aldolase family
I6G32_RS19445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G32_RS19450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G32_RS19455	COG0583	DNA-binding transcription factor activity
I6G32_RS19470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G32_RS19480	COG1770	oligopeptidase
I6G32_RS19485	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G32_RS19485	COG1024	Enoyl-CoA hydratase
I6G32_RS19490	COG0183	Belongs to the thiolase family
I6G32_RS19525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G32_RS19555	COG0653	protein targeting
I6G32_RS19575	COG0133	tryptophan synthase activity
I6G32_RS19585	COG1012	belongs to the aldehyde dehydrogenase family
I6G32_RS19590	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6G32_RS19595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G32_RS19620	COG0297	glycogen (starch) synthase activity
I6G32_RS19645	COG0297	glycogen (starch) synthase activity
I6G32_RS19660	COG3206	protein involved in exopolysaccharide biosynthesis
I6G32_RS19660	COG0489	protein tyrosine kinase activity
I6G32_RS19715	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS19730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G32_RS19735	COG0066	3-isopropylmalate dehydratase activity
I6G32_RS19765	COG0135	phosphoribosylanthranilate isomerase activity
I6G32_RS19770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G32_RS19775	COG0285	dihydrofolate synthase activity
I6G32_RS19780	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G32_RS19785	COG1286	toxin biosynthetic process
I6G32_RS19820	COG0789	Transcriptional regulator
I6G32_RS19855	COG4771	TonB-dependent receptor
I6G32_RS19860	COG0254	rRNA binding
I6G32_RS19875	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6G32_RS19880	COG2814	Major facilitator Superfamily
I6G32_RS19905	COG1271	oxidase subunit
I6G32_RS19910	COG1294	oxidase, subunit
I6G32_RS19930	COG1902	pentaerythritol trinitrate reductase activity
I6G32_RS19930	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G32_RS19960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G32_RS19975	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6G32_RS19980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G32_RS19995	COG0573	inorganic phosphate transmembrane transporter activity
I6G32_RS20010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G32_RS20015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G32_RS20025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G32_RS20055	COG2010	Cytochrome c
I6G32_RS20070	COG3278	Belongs to the heme-copper respiratory oxidase family
I6G32_RS20075	COG2010	Cytochrome c
I6G32_RS20085	COG3278	Belongs to the heme-copper respiratory oxidase family
I6G32_RS20095	COG0840	transmembrane signaling receptor activity
I6G32_RS20105	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6G32_RS20125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G32_RS20130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G32_RS20130	COG2010	Cytochrome c
I6G32_RS20145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G32_RS20150	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G32_RS20160	COG3115	cell septum assembly
I6G32_RS20165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G32_RS20170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G32_RS20210	COG2009	succinate dehydrogenase
I6G32_RS20215	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G32_RS20220	COG1053	succinate dehydrogenase
I6G32_RS20225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G32_RS20245	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G32_RS20280	COG0326	Molecular chaperone. Has ATPase activity
I6G32_RS20310	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G32_RS20320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G32_RS20325	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G32_RS20360	COG0628	permease
I6G32_RS20370	COG0709	Synthesizes selenophosphate from selenide and ATP
I6G32_RS20375	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6G32_RS20385	COG0714	Associated with various cellular activities
I6G32_RS20410	COG1238	metal cluster binding
I6G32_RS20425	COG0183	Belongs to the thiolase family
I6G32_RS20430	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS20440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G32_RS20455	COG1960	acyl-CoA dehydrogenase activity
I6G32_RS20460	COG1024	Enoyl-CoA hydratase
I6G32_RS20490	COG0058	SHG alpha-glucan phosphorylase activity
I6G32_RS20505	COG2207	Transcriptional regulator
I6G32_RS20520	COG4991	sh3 domain protein
I6G32_RS20525	COG4191	Histidine kinase
I6G32_RS20525	COG0784	Response regulator, receiver
I6G32_RS20530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G32_RS20550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G32_RS20565	COG3447	MASE1 domain protein
I6G32_RS20565	COG5001	Diguanylate cyclase
I6G32_RS20565	COG5002	protein histidine kinase activity
I6G32_RS20605	COG0210	DNA helicase
I6G32_RS20610	COG0515	serine threonine protein kinase
I6G32_RS20620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G32_RS20620	COG2146	nitrite reductase [NAD(P)H] activity
I6G32_RS20625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G32_RS20625	COG2146	nitrite reductase [NAD(P)H] activity
I6G32_RS20640	COG0840	transmembrane signaling receptor activity
I6G32_RS20645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G32_RS20660	COG4221	oxidoreductase activity
I6G32_RS20670	COG0415	Belongs to the DNA photolyase family
I6G32_RS20675	COG0789	Transcriptional regulator
I6G32_RS20680	COG3272	Protein of unknown function (DUF1722)
I6G32_RS20685	COG1090	epimerase
I6G32_RS20690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G32_RS20700	COG1366	Belongs to the anti-sigma-factor antagonist family
I6G32_RS20720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G32_RS20725	COG0302	gtp cyclohydrolase
I6G32_RS20740	COG0789	Transcriptional regulator
I6G32_RS20745	COG1025	Belongs to the peptidase M16 family
I6G32_RS20760	COG0784	Response regulator, receiver
I6G32_RS20760	COG2205	protein histidine kinase activity
I6G32_RS20765	COG0435	Glutathione S-transferase
I6G32_RS20770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G32_RS20775	COG2920	part of a sulfur-relay system
I6G32_RS20825	COG0174	glutamine synthetase
I6G32_RS20830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G32_RS20835	COG1116	anion transmembrane transporter activity
I6G32_RS20840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G32_RS20850	COG1335	isochorismatase
I6G32_RS20870	COG1028	Short-chain dehydrogenase reductase Sdr
I6G32_RS20880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G32_RS20895	COG4770	biotin carboxylase activity
I6G32_RS20910	COG3665	Urea carboxylase-associated protein
I6G32_RS20915	COG3842	ATPase activity
I6G32_RS20930	COG0084	hydrolase, TatD family'
I6G32_RS20935	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G32_RS20955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G32_RS20960	COG4181	ATPase activity
I6G32_RS20990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G32_RS20995	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G32_RS21010	COG0560	Phosphoserine phosphatase
I6G32_RS21035	COG1802	Transcriptional regulator
I6G32_RS21045	COG0372	Belongs to the citrate synthase family
I6G32_RS21060	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6G32_RS21070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G32_RS21085	COG0668	transmembrane transport
I6G32_RS21120	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G32_RS21125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G32_RS21130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G32_RS21135	COG0167	dihydroorotate dehydrogenase activity
I6G32_RS21165	COG0784	Response regulator, receiver
I6G32_RS21165	COG4191	Histidine kinase
I6G32_RS21170	COG0784	Response regulator, receiver
I6G32_RS21170	COG4191	Histidine kinase