locus-tag	class	description
L1776_RS00030	COG2194	sulfuric ester hydrolase activity
L1776_RS00040	COG1192	Involved in chromosome partitioning
L1776_RS00045	COG1215	transferase activity, transferring glycosyl groups
L1776_RS00050	COG1215	transferase activity, transferring glycosyl groups
L1776_RS00055	COG0457	Tetratricopeptide repeat
L1776_RS00055	COG3118	belongs to the thioredoxin family
L1776_RS00060	COG2183	response to ionizing radiation
L1776_RS00070	COG2918	glutathione biosynthetic process
L1776_RS00090	COG0306	phosphate transporter
L1776_RS00095	COG1392	Phosphate transport regulator
L1776_RS00105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L1776_RS00115	COG2989	Protein conserved in bacteria
L1776_RS00130	COG1764	response to oxidative stress
L1776_RS00135	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L1776_RS00160	COG2814	Major facilitator Superfamily
L1776_RS00165	COG0583	DNA-binding transcription factor activity
L1776_RS00190	COG1116	anion transmembrane transporter activity
L1776_RS00195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1776_RS00200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1776_RS00205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1776_RS00210	COG0431	NADPH-dependent FMN reductase
L1776_RS00215	COG0450	alkyl hydroperoxide reductase
L1776_RS00225	COG5583	Uncharacterized small protein (DUF2292)
L1776_RS00230	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L1776_RS00240	COG4208	sulfate ABC transporter
L1776_RS00250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L1776_RS00280	COG2205	protein histidine kinase activity
L1776_RS00285	COG1082	Xylose isomerase domain protein TIM barrel
L1776_RS00285	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L1776_RS00295	COG0583	DNA-binding transcription factor activity
L1776_RS00305	COG1301	dicarboxylic acid transport
L1776_RS00315	COG1115	amino acid carrier protein
L1776_RS00320	COG0252	asparaginase activity
L1776_RS00335	COG2066	Belongs to the glutaminase family
L1776_RS00350	COG0511	ligase activity, forming carbon-carbon bonds
L1776_RS00350	COG5016	pyruvate
L1776_RS00355	COG0439	Biotin carboxylase
L1776_RS00360	COG0583	DNA-binding transcription factor activity
L1776_RS00370	COG1737	Transcriptional regulator
L1776_RS00370	COG0837	glucose binding
L1776_RS00375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L1776_RS00385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L1776_RS00390	COG1917	Cupin 2, conserved barrel domain protein
L1776_RS00395	COG5285	phytanoyl-CoA dioxygenase
L1776_RS00400	COG0527	aspartate kinase activity
L1776_RS00405	COG2841	Protein conserved in bacteria
L1776_RS00410	COG0826	peptidase U32
L1776_RS00420	COG0210	DNA helicase
L1776_RS00425	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L1776_RS00440	COG1764	response to oxidative stress
L1776_RS00455	COG0437	4 iron, 4 sulfur cluster binding
L1776_RS00460	COG2864	formate dehydrogenase
L1776_RS00465	COG3058	Necessary for formate dehydrogenase activity
L1776_RS00470	COG1921	L-seryl-tRNASec selenium transferase activity
L1776_RS00475	COG3276	selenocysteine insertion sequence binding
L1776_RS00490	COG0509	glycine decarboxylation via glycine cleavage system
L1776_RS00500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L1776_RS00505	COG0589	response to stress
L1776_RS00515	COG4191	Histidine kinase
L1776_RS00520	COG2204	response regulator
L1776_RS00530	COG3795	YCII-related domain
L1776_RS00555	COG4191	Histidine kinase
L1776_RS00555	COG0784	Response regulator, receiver
L1776_RS00560	COG1960	acyl-CoA dehydrogenase activity
L1776_RS00565	COG2706	6-phosphogluconolactonase activity
L1776_RS00580	COG1256	bacterial-type flagellum assembly
L1776_RS00580	COG4786	Flagellar basal body rod
L1776_RS00585	COG0741	lytic transglycosylase activity
L1776_RS00590	COG1706	bacterial-type flagellum-dependent cell motility
L1776_RS00600	COG4786	Flagellar basal body rod
L1776_RS00605	COG4787	bacterial-type flagellum-dependent cell motility
L1776_RS00615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
L1776_RS00620	COG1558	bacterial-type flagellum-dependent cell motility
L1776_RS00625	COG1815	bacterial-type flagellum-dependent cell motility
L1776_RS00635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L1776_RS00655	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L1776_RS00660	COG1191	sigma factor activity
L1776_RS00685	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
L1776_RS00715	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L1776_RS00765	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L1776_RS00815	COG0583	DNA-binding transcription factor activity
L1776_RS00820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L1776_RS00895	COG2249	NAD(P)H dehydrogenase (quinone) activity
L1776_RS00905	COG2207	Transcriptional regulator
L1776_RS00980	COG1611	Belongs to the LOG family
L1776_RS00995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L1776_RS01000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L1776_RS01005	COG0318	PFAM AMP-dependent synthetase and ligase
L1776_RS01025	COG2814	Major facilitator Superfamily
L1776_RS01035	COG1960	acyl-CoA dehydrogenase activity
L1776_RS01040	COG1024	Enoyl-CoA hydratase
L1776_RS01040	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1776_RS01050	COG1012	belongs to the aldehyde dehydrogenase family
L1776_RS01055	COG3909	cytochrome
L1776_RS01060	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
L1776_RS01105	COG0515	serine threonine protein kinase
L1776_RS01135	COG2010	Cytochrome c
L1776_RS01140	COG0753	catalase activity
L1776_RS01145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1776_RS01150	COG1127	ABC transporter
L1776_RS01165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1776_RS01170	COG0842	Transport permease protein
L1776_RS01170	COG1129	ABC transporter
L1776_RS01175	COG0842	Transport permease protein
L1776_RS01245	COG4771	TonB-dependent receptor
L1776_RS01260	COG1116	anion transmembrane transporter activity
L1776_RS01270	COG1177	transmembrane transport
L1776_RS01275	COG1176	ABC-type spermidine putrescine transport system, permease component I
L1776_RS01280	COG3842	ATPase activity
L1776_RS01305	COG0174	glutamine synthetase
L1776_RS01310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L1776_RS01315	COG0174	glutamine synthetase
L1776_RS01330	COG2957	Belongs to the agmatine deiminase family
L1776_RS01340	COG3706	GGDEF domain
L1776_RS01350	COG4191	Histidine kinase
L1776_RS01355	COG0745	RESPONSE REGULATOR receiver
L1776_RS01360	COG5002	protein histidine kinase activity
L1776_RS01365	COG0745	RESPONSE REGULATOR receiver
L1776_RS01375	COG5002	protein histidine kinase activity
L1776_RS01380	COG0745	RESPONSE REGULATOR receiver
L1776_RS01400	COG1012	belongs to the aldehyde dehydrogenase family
L1776_RS01405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L1776_RS01415	COG0735	belongs to the Fur family
L1776_RS01420	COG1121	(ABC) transporter
L1776_RS01425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L1776_RS01430	COG1451	nucleotide metabolic process
L1776_RS01445	COG2011	ABC-type metal ion transport system permease component
L1776_RS01485	COG1686	Belongs to the peptidase S11 family
L1776_RS01500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L1776_RS01505	COG0408	coproporphyrinogen oxidase activity
L1776_RS01515	COG0009	L-threonylcarbamoyladenylate synthase
L1776_RS01520	COG0758	DNA mediated transformation
L1776_RS01530	COG0242	peptide deformylase activity
L1776_RS01535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L1776_RS01540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L1776_RS01545	COG0569	domain protein
L1776_RS01550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1776_RS01555	COG0765	amino acid transport
L1776_RS01560	COG0765	amino acid transport
L1776_RS01565	COG1126	abc transporter atp-binding protein
L1776_RS01585	COG2818	Glycosylase
L1776_RS01595	COG0751	glycine-tRNA ligase activity
L1776_RS01610	COG3706	GGDEF domain
L1776_RS01625	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L1776_RS01635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L1776_RS01640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L1776_RS01645	COG0594	ribonuclease P activity
L1776_RS01650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L1776_RS01655	COG0706	membrane insertase activity
L1776_RS01660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L1776_RS01665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L1776_RS01665	COG2111	Na H antiporter
L1776_RS01670	COG2111	Na H antiporter
L1776_RS01675	COG1006	Multisubunit Na H antiporter MnhC subunit
L1776_RS01680	COG0651	ATP synthesis coupled electron transport
L1776_RS01695	COG1320	monovalent cation:proton antiporter activity
L1776_RS01700	COG0445	tRNA wobble uridine modification
L1776_RS01705	COG0357	Ribosomal RNA small subunit methyltransferase G
L1776_RS01710	COG1192	Involved in chromosome partitioning
L1776_RS01715	COG1475	DNA binding
L1776_RS01720	COG3312	ion transport
L1776_RS01725	COG0356	it plays a direct role in the translocation of protons across the membrane
L1776_RS01735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L1776_RS01740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L1776_RS01745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L1776_RS01750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L1776_RS01755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L1776_RS01760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L1776_RS01765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L1776_RS01775	COG1349	DNA-binding transcription factor activity
L1776_RS01780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1776_RS01795	COG0784	Response regulator, receiver
L1776_RS01800	COG4251	negative regulation of phosphorylation
L1776_RS01815	COG0523	cobalamin synthesis protein
L1776_RS01830	COG1595	DNA-templated transcription, initiation
L1776_RS01855	COG0109	protoheme IX farnesyltransferase activity
L1776_RS01885	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
L1776_RS01890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L1776_RS01895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L1776_RS01905	COG0659	secondary active sulfate transmembrane transporter activity
L1776_RS01935	COG0339	signal peptide processing
L1776_RS01940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L1776_RS01975	COG0583	DNA-binding transcription factor activity
L1776_RS01980	COG2323	membrane
L1776_RS02040	COG1132	(ABC) transporter
L1776_RS02045	COG3340	Belongs to the peptidase S51 family
L1776_RS02060	COG0737	Belongs to the 5'-nucleotidase family
L1776_RS02060	COG1525	nuclease
L1776_RS02060	COG4085	toxin activity
L1776_RS02080	COG0625	glutathione transferase activity
L1776_RS02085	COG3360	Dodecin
L1776_RS02095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1776_RS02135	COG2358	TRAP transporter, solute receptor (TAXI family
L1776_RS02150	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
L1776_RS02155	COG4221	oxidoreductase activity
L1776_RS02165	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L1776_RS02170	COG3052	prosthetic group binding
L1776_RS02190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L1776_RS02205	COG0840	transmembrane signaling receptor activity
L1776_RS02240	COG2204	response regulator
L1776_RS02295	COG0676	glucose-6-phosphate 1-epimerase activity
L1776_RS02330	COG1525	nuclease
L1776_RS02385	COG0582	viral genome integration into host DNA
L1776_RS02395	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
L1776_RS02400	COG1194	a g-specific adenine glycosylase
L1776_RS02415	COG1116	anion transmembrane transporter activity
L1776_RS02425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1776_RS02430	COG3707	response regulator
L1776_RS02435	COG0131	Imidazoleglycerol-phosphate dehydratase
L1776_RS02450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L1776_RS02455	COG0107	imidazoleglycerol-phosphate synthase activity
L1776_RS02470	COG2861	carbohydrate metabolic process
L1776_RS02475	COG0793	Belongs to the peptidase S41A family
L1776_RS02480	COG4942	peptidase
L1776_RS02485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L1776_RS02490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L1776_RS02500	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
L1776_RS02525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L1776_RS02545	COG3079	Belongs to the UPF0149 family
L1776_RS02550	COG0006	proline dipeptidase activity
L1776_RS02555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1776_RS02565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1776_RS02575	COG1178	ABC-type Fe3 transport system permease component
L1776_RS02590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L1776_RS02590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L1776_RS02595	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L1776_RS02620	COG3023	N-Acetylmuramoyl-L-alanine amidase
L1776_RS02630	COG5002	protein histidine kinase activity
L1776_RS02635	COG2204	response regulator
L1776_RS02655	COG0700	Nucleoside recognition
L1776_RS02665	COG2358	TRAP transporter, solute receptor (TAXI family
L1776_RS02680	COG0840	transmembrane signaling receptor activity
L1776_RS02685	COG4251	negative regulation of phosphorylation
L1776_RS02685	COG3706	GGDEF domain
L1776_RS02685	COG5001	Diguanylate cyclase
L1776_RS02685	COG2203	Gaf domain
L1776_RS02720	COG3180	Ammonia monooxygenase
L1776_RS02735	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L1776_RS02740	COG1074	ATP-dependent DNA helicase activity
L1776_RS02745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L1776_RS02760	COG4251	negative regulation of phosphorylation
L1776_RS02760	COG5001	Diguanylate cyclase
L1776_RS02760	COG2203	Gaf domain
L1776_RS02760	COG3706	GGDEF domain
L1776_RS02765	COG1607	acyl-coa hydrolase
L1776_RS02780	COG0573	inorganic phosphate transmembrane transporter activity
L1776_RS02785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1776_RS02790	COG0704	Plays a role in the regulation of phosphate uptake
L1776_RS02805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L1776_RS02815	COG0584	glycerophosphoryl diester phosphodiesterase
L1776_RS02840	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L1776_RS02845	COG0129	dihydroxy-acid dehydratase activity
L1776_RS02860	COG0693	protein deglycase activity
L1776_RS02870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1776_RS02890	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L1776_RS02895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L1776_RS02900	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
L1776_RS02930	COG0742	ribosomal rna small subunit methyltransferase
L1776_RS02935	COG0612	Peptidase, M16
L1776_RS02940	COG0612	Peptidase, M16
L1776_RS02945	COG0552	protein localization to endoplasmic reticulum
L1776_RS02950	COG2884	Cell division ATP-binding protein ftsE
L1776_RS02955	COG2177	Part of the ABC transporter FtsEX involved in
L1776_RS02975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1776_RS02980	COG2363	Small membrane protein
L1776_RS02990	COG2022	thiamine diphosphate biosynthetic process
L1776_RS02995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L1776_RS03010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L1776_RS03035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L1776_RS03040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L1776_RS03050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1776_RS03050	COG2813	Specifically methylates the guanine in position
L1776_RS03055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1776_RS03110	COG0540	Belongs to the ATCase OTCase family
L1776_RS03125	COG1678	Uncharacterized ACR, COG1678
L1776_RS03165	COG2198	Histidine kinase
L1776_RS03165	COG0784	Response regulator, receiver
L1776_RS03165	COG0643	Histidine kinase
L1776_RS03180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L1776_RS03190	COG3038	cytochrome b561
L1776_RS03195	COG2353	YceI-like domain
L1776_RS03200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1776_RS03215	COG0513	Belongs to the DEAD box helicase family
L1776_RS03220	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L1776_RS03225	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L1776_RS03245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L1776_RS03250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L1776_RS03255	COG1131	(ABC) transporter
L1776_RS03260	COG0842	Transport permease protein
L1776_RS03270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L1776_RS03275	COG2226	methyltransferase
L1776_RS03285	COG2175	clavaminate synthase activity
L1776_RS03295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L1776_RS03300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L1776_RS03305	COG0126	phosphoglycerate kinase activity
L1776_RS03320	COG0191	fructose-bisphosphate aldolase activity
L1776_RS03360	COG2081	HI0933 family
L1776_RS03370	COG1289	transmembrane transporter activity
L1776_RS03375	COG0513	Belongs to the DEAD box helicase family
L1776_RS03390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1776_RS03420	COG0840	transmembrane signaling receptor activity
L1776_RS03470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L1776_RS03480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1776_RS03485	COG1609	Transcriptional regulator
L1776_RS03500	COG4977	sequence-specific DNA binding
L1776_RS03500	COG1917	Cupin 2, conserved barrel domain protein
L1776_RS03510	COG0583	DNA-binding transcription factor activity
L1776_RS03540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1776_RS03545	COG1012	belongs to the aldehyde dehydrogenase family
L1776_RS03555	COG2721	sulfolactate sulfo-lyase activity
L1776_RS03565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L1776_RS03575	COG4774	siderophore transport
L1776_RS03605	COG0330	HflC and HflK could
L1776_RS03635	COG0784	Response regulator, receiver
L1776_RS03635	COG2198	Histidine kinase
L1776_RS03635	COG2205	protein histidine kinase activity
L1776_RS03640	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L1776_RS03650	COG5002	protein histidine kinase activity
L1776_RS03655	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L1776_RS03660	COG1196	nuclear chromosome segregation
L1776_RS03660	COG3264	Mechanosensitive ion channel
L1776_RS03665	COG3263	regulation of cellular component size
L1776_RS03670	COG1960	acyl-CoA dehydrogenase activity
L1776_RS03680	COG1304	FMN binding
L1776_RS03715	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L1776_RS03720	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L1776_RS03725	COG1040	competence protein
L1776_RS03730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L1776_RS03735	COG0156	8-amino-7-oxononanoate synthase activity
L1776_RS03740	COG1073	alpha beta
L1776_RS03740	COG2226	methyltransferase
L1776_RS03760	COG1960	acyl-CoA dehydrogenase activity
L1776_RS03770	COG1960	acyl-CoA dehydrogenase activity
L1776_RS03775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1776_RS03800	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L1776_RS03810	COG0859	PFAM glycosyl transferase family 9
L1776_RS03815	COG0859	PFAM glycosyl transferase family 9
L1776_RS03820	COG0438	transferase activity, transferring glycosyl groups
L1776_RS03845	COG2192	nodulation
L1776_RS03850	COG0438	transferase activity, transferring glycosyl groups
L1776_RS03885	COG1132	(ABC) transporter
L1776_RS03900	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L1776_RS03900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L1776_RS03910	COG0667	Aldo Keto reductase
L1776_RS03925	COG1519	Transferase
L1776_RS03930	COG1538	Outer membrane efflux protein
L1776_RS03935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L1776_RS03945	COG0494	nUDIX hydrolase
L1776_RS03955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L1776_RS03960	COG3150	esterase
L1776_RS03995	COG3830	Belongs to the UPF0237 family
L1776_RS03995	COG0560	Phosphoserine phosphatase
L1776_RS04000	COG1063	alcohol dehydrogenase
L1776_RS04005	COG2200	EAL domain
L1776_RS04015	COG0688	phosphatidylethanolamine metabolic process
L1776_RS04030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L1776_RS04035	COG1360	Flagellar Motor Protein
L1776_RS04040	COG1162	GTPase activity
L1776_RS04050	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L1776_RS04055	COG0702	epimerase
L1776_RS04075	COG1346	cytolysis
L1776_RS04085	COG0586	Pfam SNARE associated Golgi protein
L1776_RS04090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L1776_RS04095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L1776_RS04105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L1776_RS04110	COG0768	penicillin binding
L1776_RS04115	COG0772	Belongs to the SEDS family
L1776_RS04120	COG2951	lytic endotransglycosylase activity
L1776_RS04130	COG1686	Belongs to the peptidase S11 family
L1776_RS04135	COG2921	Belongs to the UPF0250 family
L1776_RS04140	COG0321	lipoyl(octanoyl) transferase activity
L1776_RS04145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L1776_RS04155	COG2951	lytic endotransglycosylase activity
L1776_RS04160	COG3036	rescue of stalled ribosome
L1776_RS04175	COG0495	leucyl-tRNA aminoacylation
L1776_RS04190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L1776_RS04195	COG4535	Mg2 and Co2 transporter CorC
L1776_RS04200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L1776_RS04205	COG1702	phosphate starvation-inducible protein PhoH
L1776_RS04210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L1776_RS04225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L1776_RS04230	COG0352	thiamine-phosphate diphosphorylase activity
L1776_RS04235	COG0351	phosphomethylpyrimidine kinase
L1776_RS04235	COG0352	thiamine-phosphate diphosphorylase activity
L1776_RS04245	COG1960	acyl-CoA dehydrogenase activity
L1776_RS04260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1776_RS04265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L1776_RS04280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L1776_RS04285	COG0830	nickel cation binding
L1776_RS04290	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
L1776_RS04305	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L1776_RS04310	COG2814	Major facilitator Superfamily
L1776_RS04320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L1776_RS04330	COG1953	Uracil, thiamine, allantoin
L1776_RS04335	COG0804	urea catabolic process
L1776_RS04340	COG0832	Belongs to the urease beta subunit family
L1776_RS04350	COG0831	urea catabolic process
L1776_RS04355	COG0829	nickel cation binding
L1776_RS04405	COG1522	sequence-specific DNA binding
L1776_RS04420	COG1643	Atp-dependent helicase
L1776_RS04430	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS04450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L1776_RS04455	COG0142	geranyltranstransferase activity
L1776_RS04460	COG1722	exodeoxyribonuclease VII activity
L1776_RS04485	COG3486	L-lysine 6-monooxygenase (NADPH) activity
L1776_RS04490	COG0076	glutamate decarboxylase activity
L1776_RS04500	COG3300	MHYT domain
L1776_RS04500	COG5001	Diguanylate cyclase
L1776_RS04525	COG3228	Belongs to the MtfA family
L1776_RS04545	COG4303	Ethanolamine ammonia lyase large subunit
L1776_RS04550	COG0531	amino acid
L1776_RS04560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L1776_RS04585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L1776_RS04585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L1776_RS04590	COG0802	atpase or kinase
L1776_RS04595	COG0860	N-Acetylmuramoyl-L-alanine amidase
L1776_RS04600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L1776_RS04605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L1776_RS04610	COG1923	regulation of RNA biosynthetic process
L1776_RS04615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L1776_RS04620	COG0330	HflC and HflK could
L1776_RS04625	COG0330	HflC and HflK could
L1776_RS04630	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
L1776_RS04635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L1776_RS04655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1776_RS04665	COG0360	Binds together with S18 to 16S ribosomal RNA
L1776_RS04670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L1776_RS04680	COG0359	binds to the 23S rRNA
L1776_RS04685	COG0305	Participates in initiation and elongation during chromosome replication
L1776_RS04690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L1776_RS04695	COG5001	Diguanylate cyclase
L1776_RS04695	COG3300	MHYT domain
L1776_RS04770	COG1252	NADH dehydrogenase
L1776_RS04795	COG2945	thiolester hydrolase activity
L1776_RS04800	COG0180	Tryptophanyl-tRNA synthetase
L1776_RS04805	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L1776_RS04815	COG1515	deoxyribonuclease V activity
L1776_RS04820	COG3023	N-Acetylmuramoyl-L-alanine amidase
L1776_RS04830	COG0840	transmembrane signaling receptor activity
L1776_RS04835	COG0084	hydrolase, TatD family'
L1776_RS04845	COG2169	Transcriptional regulator
L1776_RS04845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L1776_RS04860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1776_RS04875	COG0840	transmembrane signaling receptor activity
L1776_RS04885	COG2217	Heavy metal translocating P-type atpase
L1776_RS04895	COG1309	transcriptional regulator
L1776_RS04900	COG2814	Major facilitator Superfamily
L1776_RS04910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L1776_RS04940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L1776_RS04945	COG0778	Nitroreductase
L1776_RS04950	COG0596	Alpha beta hydrolase
L1776_RS04955	COG0251	oxidation-reduction process
L1776_RS04960	COG1335	isochorismatase
L1776_RS04965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1776_RS04970	COG1309	transcriptional regulator
L1776_RS04985	COG4977	sequence-specific DNA binding
L1776_RS04995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1776_RS05005	COG0346	lactoylglutathione lyase activity
L1776_RS05040	COG3845	ABC transporter
L1776_RS05050	COG1079	Belongs to the binding-protein-dependent transport system permease family
L1776_RS05070	COG1278	Cold shock
L1776_RS05075	COG2824	Alkylphosphonate utilization operon protein PhnA
L1776_RS05080	COG1607	acyl-coa hydrolase
L1776_RS05090	COG0402	S-adenosylhomocysteine deaminase activity
L1776_RS05095	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L1776_RS05110	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
L1776_RS05125	COG2154	pterin-4-alpha-carbinolamine dehydratase
L1776_RS05145	COG1760	l-serine dehydratase
L1776_RS05150	COG0492	ferredoxin-NADP+ reductase activity
L1776_RS05165	COG3189	MarR family transcriptional regulator
L1776_RS05180	COG1960	acyl-CoA dehydrogenase activity
L1776_RS05185	COG0348	domain, Protein
L1776_RS05185	COG3901	Regulator of nitric oxide reductase transcription
L1776_RS05190	COG4263	nitrous-oxide reductase activity
L1776_RS05205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L1776_RS05225	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS05230	COG0840	transmembrane signaling receptor activity
L1776_RS05255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L1776_RS05255	COG1648	precorrin-2 dehydrogenase activity
L1776_RS05260	COG0535	radical SAM domain protein
L1776_RS05270	COG1845	cytochrome c oxidase, subunit III
L1776_RS05275	COG0714	Associated with various cellular activities
L1776_RS05280	COG2010	Cytochrome c
L1776_RS05300	COG2010	Cytochrome c
L1776_RS05305	COG3391	amine dehydrogenase activity
L1776_RS05330	COG2010	Cytochrome c
L1776_RS05335	COG3256	nitric oxide reductase
L1776_RS05365	COG3604	Transcriptional regulator
L1776_RS05375	COG0826	peptidase U32
L1776_RS05380	COG0826	peptidase U32
L1776_RS05385	COG3154	lipid carrier protein
L1776_RS05435	COG2814	Major facilitator Superfamily
L1776_RS05455	COG1737	Transcriptional regulator
L1776_RS05470	COG0800	Aldolase
L1776_RS05480	COG4989	oxidoreductase activity
L1776_RS05495	COG4580	involved in the transport of maltose and maltodextrins
L1776_RS05510	COG0366	Alpha amylase catalytic
L1776_RS05520	COG1175	transmembrane transport
L1776_RS05525	COG3833	ABC-type maltose transport systems, permease component
L1776_RS05530	COG2909	trisaccharide binding
L1776_RS05550	COG0366	Alpha amylase catalytic
L1776_RS05565	COG1280	lysine exporter protein (LysE YggA)
L1776_RS05595	COG1139	Iron-sulfur cluster binding protein
L1776_RS05600	COG0247	lactate metabolic process
L1776_RS05605	COG1620	l-lactate permease
L1776_RS05615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L1776_RS05625	COG2914	Belongs to the UPF0125 (RnfH) family
L1776_RS05630	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L1776_RS05640	COG0497	DNA recombination
L1776_RS05645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L1776_RS05650	COG0443	Heat shock 70 kDa protein
L1776_RS05655	COG0484	heat shock protein binding
L1776_RS05660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L1776_RS05665	COG0505	Belongs to the CarA family
L1776_RS05695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L1776_RS05700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1776_RS05705	COG0149	triose-phosphate isomerase activity
L1776_RS05710	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L1776_RS05725	COG0779	Required for maturation of 30S ribosomal subunits
L1776_RS05730	COG0195	Participates in both transcription termination and antitermination
L1776_RS05730	COG2251	uridine kinase activity
L1776_RS05735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L1776_RS05740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L1776_RS05745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L1776_RS05750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L1776_RS05755	COG1185	polyribonucleotide nucleotidyltransferase activity
L1776_RS05780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L1776_RS05790	COG0166	Belongs to the GPI family
L1776_RS05795	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L1776_RS05800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L1776_RS05805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L1776_RS05825	COG4191	Histidine kinase
L1776_RS05835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L1776_RS05840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L1776_RS05845	COG0436	Aminotransferase
L1776_RS05860	COG0679	Auxin Efflux Carrier
L1776_RS05875	COG2124	cytochrome p450
L1776_RS05880	COG5002	protein histidine kinase activity
L1776_RS05880	COG0784	Response regulator, receiver
L1776_RS05880	COG2205	protein histidine kinase activity
L1776_RS05890	COG0138	bifunctional purine biosynthesis protein purh
L1776_RS05910	COG2264	protein methyltransferase activity
L1776_RS05925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L1776_RS05940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1776_RS05975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1776_RS05995	COG0028	Belongs to the TPP enzyme family
L1776_RS06005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L1776_RS06010	COG1183	phosphatidylcholine synthase activity
L1776_RS06050	COG2995	paraquat-inducible protein a
L1776_RS06055	COG2995	paraquat-inducible protein a
L1776_RS06060	COG3008	intermembrane lipid transfer
L1776_RS06080	COG0019	diaminopimelate decarboxylase activity
L1776_RS06090	COG2851	Citrate transporter
L1776_RS06110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1776_RS06120	COG0456	acetyltransferase
L1776_RS06135	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L1776_RS06140	COG0288	reversible hydration of carbon dioxide
L1776_RS06145	COG0697	spore germination
L1776_RS06175	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L1776_RS06190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L1776_RS06200	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
L1776_RS06205	COG0789	Transcriptional regulator
L1776_RS06235	COG1024	Enoyl-CoA hydratase
L1776_RS06240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L1776_RS06245	COG1960	acyl-CoA dehydrogenase activity
L1776_RS06250	COG4294	response to UV
L1776_RS06255	COG0318	PFAM AMP-dependent synthetase and ligase
L1776_RS06285	COG0559	Belongs to the binding-protein-dependent transport system permease family
L1776_RS06310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L1776_RS06330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L1776_RS06335	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L1776_RS06345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L1776_RS06350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L1776_RS06360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L1776_RS06365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L1776_RS06385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L1776_RS06390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L1776_RS06435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L1776_RS06475	COG2096	Adenosyltransferase
L1776_RS06480	COG4191	Histidine kinase
L1776_RS06490	COG0745	RESPONSE REGULATOR receiver
L1776_RS06495	COG1666	GTP binding
L1776_RS06500	COG0668	transmembrane transport
L1776_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS06530	COG3030	protein affecting phage T7 exclusion by the F plasmid
L1776_RS06535	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L1776_RS06540	COG0459	protein refolding
L1776_RS06550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1776_RS06555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1776_RS06585	COG1704	LemA family
L1776_RS06610	COG1279	arginine transmembrane transporter activity
L1776_RS06615	COG0583	DNA-binding transcription factor activity
L1776_RS06635	COG3706	GGDEF domain
L1776_RS06640	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L1776_RS06655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L1776_RS06655	COG1017	nitric oxide dioxygenase activity
L1776_RS06665	COG4413	Urea transporter
L1776_RS06670	COG0469	pyruvate kinase activity
L1776_RS06680	COG2084	Dehydrogenase
L1776_RS06685	COG3622	Belongs to the hyi family
L1776_RS06690	COG3960	tartronate-semialdehyde synthase activity
L1776_RS06695	COG0583	DNA-binding transcription factor activity
L1776_RS06700	COG2351	hydroxyisourate hydrolase activity
L1776_RS06720	COG0708	Exodeoxyribonuclease III
L1776_RS06725	COG3300	MHYT domain
L1776_RS06725	COG5001	Diguanylate cyclase
L1776_RS06750	COG1309	transcriptional regulator
L1776_RS06755	COG0840	transmembrane signaling receptor activity
L1776_RS06770	COG2233	PERMEase
L1776_RS06775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L1776_RS06775	COG4651	solute:proton antiporter activity
L1776_RS06780	COG2233	PERMEase
L1776_RS06790	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L1776_RS06795	COG4266	Belongs to the allantoicase family
L1776_RS06820	COG2252	PERMEase
L1776_RS06825	COG1802	Transcriptional regulator
L1776_RS06830	COG1121	(ABC) transporter
L1776_RS06840	COG0803	Belongs to the bacterial solute-binding protein 9 family
L1776_RS06845	COG0402	S-adenosylhomocysteine deaminase activity
L1776_RS06885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L1776_RS06890	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L1776_RS06910	COG2326	polyphosphate kinase activity
L1776_RS06915	COG3081	Nucleoid-associated protein
L1776_RS06935	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
L1776_RS06940	COG0477	Major facilitator Superfamily
L1776_RS06945	COG0471	metal ion transport
L1776_RS06945	COG0490	domain, Protein
L1776_RS06975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L1776_RS06980	COG0795	lipopolysaccharide-transporting ATPase activity
L1776_RS06985	COG0795	lipopolysaccharide-transporting ATPase activity
L1776_RS06995	COG1278	Cold shock
L1776_RS07015	COG1862	Preprotein translocase
L1776_RS07030	COG3134	Outer membrane lipoprotein
L1776_RS07060	COG1104	cysteine desulfurase activity
L1776_RS07070	COG0316	Belongs to the HesB IscA family
L1776_RS07075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L1776_RS07080	COG0443	Heat shock 70 kDa protein
L1776_RS07095	COG0105	UTP biosynthetic process
L1776_RS07100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L1776_RS07115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L1776_RS07120	COG0124	histidyl-tRNA synthetase
L1776_RS07125	COG2976	Protein conserved in bacteria
L1776_RS07135	COG1160	GTP binding
L1776_RS07145	COG0436	Aminotransferase
L1776_RS07160	COG2264	protein methyltransferase activity
L1776_RS07170	COG3647	Membrane
L1776_RS07175	COG2356	endonuclease I
L1776_RS07185	COG1064	alcohol dehydrogenase
L1776_RS07190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1776_RS07205	COG0668	transmembrane transport
L1776_RS07215	COG0739	heme binding
L1776_RS07220	COG1570	exodeoxyribonuclease VII activity
L1776_RS07235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L1776_RS07235	COG0519	Catalyzes the synthesis of GMP from XMP
L1776_RS07240	COG2132	Multicopper oxidase
L1776_RS07245	COG0590	tRNA wobble adenosine to inosine editing
L1776_RS07250	COG3842	ATPase activity
L1776_RS07260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L1776_RS07280	COG0556	nucleotide-excision repair
L1776_RS07285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L1776_RS07320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L1776_RS07370	COG3639	organic phosphonate transmembrane transporter activity
L1776_RS07375	COG3639	organic phosphonate transmembrane transporter activity
L1776_RS07385	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
L1776_RS07395	COG1968	undecaprenyl-diphosphatase activity
L1776_RS07400	COG2084	Dehydrogenase
L1776_RS07405	COG3622	Belongs to the hyi family
L1776_RS07410	COG2271	Major facilitator Superfamily
L1776_RS07415	COG0443	Heat shock 70 kDa protein
L1776_RS07425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L1776_RS07450	COG2030	dehydratase
L1776_RS07455	COG0318	PFAM AMP-dependent synthetase and ligase
L1776_RS07480	COG1643	Atp-dependent helicase
L1776_RS07495	COG0515	serine threonine protein kinase
L1776_RS07495	COG2815	serine threonine protein kinase
L1776_RS07500	COG0631	protein serine/threonine phosphatase activity
L1776_RS07505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1776_RS07510	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
L1776_RS07515	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
L1776_RS07520	COG3257	ureidoglycine aminohydrolase activity
L1776_RS07535	COG1234	tRNA 3'-trailer cleavage
L1776_RS07545	COG2851	Citrate transporter
L1776_RS07560	COG3795	YCII-related domain
L1776_RS07575	COG2258	MOSC domain
L1776_RS07585	COG0537	adenosine 5'-monophosphoramidase activity
L1776_RS07605	COG2733	membrane
L1776_RS07630	COG1279	arginine transmembrane transporter activity
L1776_RS07655	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1776_RS07655	COG0596	Alpha beta hydrolase
L1776_RS07675	COG2814	Major facilitator Superfamily
L1776_RS07685	COG0471	metal ion transport
L1776_RS07685	COG0490	domain, Protein
L1776_RS07695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1776_RS07700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L1776_RS07710	COG1301	dicarboxylic acid transport
L1776_RS07725	COG1079	Belongs to the binding-protein-dependent transport system permease family
L1776_RS07730	COG4603	Belongs to the binding-protein-dependent transport system permease family
L1776_RS07735	COG3845	ABC transporter
L1776_RS07740	COG2207	Transcriptional regulator
L1776_RS07750	COG4221	oxidoreductase activity
L1776_RS07760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1776_RS07770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1776_RS07785	COG0159	tryptophan synthase activity
L1776_RS07825	COG1132	(ABC) transporter
L1776_RS07830	COG4249	Peptidase C14 caspase catalytic subunit p20
L1776_RS07840	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
L1776_RS07860	COG1280	lysine exporter protein (LysE YggA)
L1776_RS07885	COG0625	glutathione transferase activity
L1776_RS07890	COG0583	DNA-binding transcription factor activity
L1776_RS07920	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1776_RS07925	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1776_RS07930	COG0022	dehydrogenase e1 component
L1776_RS07935	COG1063	alcohol dehydrogenase
L1776_RS07940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L1776_RS07955	COG3284	Transcriptional regulator
L1776_RS07965	COG0604	alcohol dehydrogenase
L1776_RS07965	COG3321	synthase
L1776_RS07980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L1776_RS07985	COG0116	Belongs to the methyltransferase superfamily
L1776_RS07985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L1776_RS07995	COG0189	ligase activity
L1776_RS07995	COG4067	protein conserved in archaea
L1776_RS08000	COG0583	DNA-binding transcription factor activity
L1776_RS08005	COG1309	transcriptional regulator
L1776_RS08025	COG1462	curli production assembly transport component CsgG
L1776_RS08045	COG1280	lysine exporter protein (LysE YggA)
L1776_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS08060	COG0583	DNA-binding transcription factor activity
L1776_RS08065	COG3932	Exopolysaccharide synthesis, ExoD
L1776_RS08070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L1776_RS08080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L1776_RS08090	COG3530	Putative quorum-sensing-regulated virulence factor
L1776_RS08100	COG2863	cytochrome
L1776_RS08105	COG3258	Cytochrome c
L1776_RS08115	COG2166	iron-sulfur cluster assembly
L1776_RS08120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L1776_RS08125	COG2171	N-acyltransferase activity
L1776_RS08130	COG1393	Belongs to the ArsC family
L1776_RS08150	COG0436	Aminotransferase
L1776_RS08165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L1776_RS08170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L1776_RS08180	COG0628	permease
L1776_RS08185	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L1776_RS08200	COG1393	Belongs to the ArsC family
L1776_RS08205	COG1295	ribonuclease BN
L1776_RS08220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1776_RS08235	COG0442	prolyl-tRNA aminoacylation
L1776_RS08250	COG2900	Belongs to the SlyX family
L1776_RS08260	COG0783	Belongs to the Dps family
L1776_RS08265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L1776_RS08275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L1776_RS08280	COG0632	four-way junction helicase activity
L1776_RS08285	COG2255	four-way junction helicase activity
L1776_RS08290	COG0824	Thioesterase
L1776_RS08310	COG0823	Involved in the tonB-independent uptake of proteins
L1776_RS08315	COG2885	chlorophyll binding
L1776_RS08320	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
L1776_RS08325	COG0602	queuosine metabolic process
L1776_RS08330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L1776_RS08340	COG0427	acetyl-CoA hydrolase
L1776_RS08345	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L1776_RS08355	COG0425	Belongs to the sulfur carrier protein TusA family
L1776_RS08365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L1776_RS08375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1776_RS08385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L1776_RS08395	COG0417	DNA replication proofreading
L1776_RS08430	COG3174	membrane
L1776_RS08435	COG2205	protein histidine kinase activity
L1776_RS08455	COG2814	Major facilitator Superfamily
L1776_RS08460	COG2974	May be involved in recombination
L1776_RS08475	COG0545	Peptidyl-prolyl cis-trans isomerase
L1776_RS08500	COG1914	H( )-stimulated, divalent metal cation uptake system
L1776_RS08505	COG4336	lyase activity
L1776_RS08510	COG1984	allophanate hydrolase subunit 2
L1776_RS08515	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L1776_RS08520	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L1776_RS08530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L1776_RS08535	COG3383	formate dehydrogenase (NAD+) activity
L1776_RS08540	COG1902	pentaerythritol trinitrate reductase activity
L1776_RS08555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L1776_RS08595	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L1776_RS08600	COG0563	adenylate kinase activity
L1776_RS08625	COG0742	ribosomal rna small subunit methyltransferase
L1776_RS08635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1776_RS08645	COG1309	transcriptional regulator
L1776_RS08665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1776_RS08670	COG0348	domain, Protein
L1776_RS08675	COG1380	Effector of murein hydrolase LrgA
L1776_RS08680	COG1346	cytolysis
L1776_RS08690	COG1472	Belongs to the glycosyl hydrolase 3 family
L1776_RS08700	COG2943	transferase activity, transferring hexosyl groups
L1776_RS08715	COG0655	NAD(P)H dehydrogenase (quinone) activity
L1776_RS08720	COG0456	acetyltransferase
L1776_RS08745	COG2132	Multicopper oxidase
L1776_RS08770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1776_RS08785	COG0456	acetyltransferase
L1776_RS08790	COG2937	Belongs to the GPAT DAPAT family
L1776_RS08825	COG1131	(ABC) transporter
L1776_RS08850	COG2226	methyltransferase
L1776_RS08855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1776_RS08860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L1776_RS08900	COG0513	Belongs to the DEAD box helicase family
L1776_RS08915	COG0583	DNA-binding transcription factor activity
L1776_RS08935	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L1776_RS08935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1776_RS08940	COG0784	Response regulator, receiver
L1776_RS08940	COG2205	protein histidine kinase activity
L1776_RS08940	COG5002	protein histidine kinase activity
L1776_RS08945	COG2860	membrane
L1776_RS08960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L1776_RS08965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L1776_RS08970	COG3956	TIGRFAM MazG family protein
L1776_RS09000	COG1201	RNA secondary structure unwinding
L1776_RS09005	COG1793	dna ligase
L1776_RS09020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L1776_RS09030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L1776_RS09045	COG1805	sodium ion transport
L1776_RS09060	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L1776_RS09070	COG1477	protein flavinylation
L1776_RS09080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1776_RS09085	COG0584	glycerophosphoryl diester phosphodiesterase
L1776_RS09100	COG4591	ABC-type transport system involved in lipoprotein release permease component
L1776_RS09105	COG1136	(ABC) transporter
L1776_RS09120	COG0658	competence protein
L1776_RS09120	COG2333	competence protein COMEC
L1776_RS09125	COG0811	peptide transport
L1776_RS09135	COG1663	tetraacyldisaccharide 4'-kinase activity
L1776_RS09140	COG2835	tetraacyldisaccharide 4'-kinase activity
L1776_RS09145	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L1776_RS09150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L1776_RS09155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L1776_RS09160	COG1530	ribonuclease E activity
L1776_RS09175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L1776_RS09175	COG0616	signal peptide processing
L1776_RS09180	COG0424	maF-like protein
L1776_RS09190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L1776_RS09195	COG0416	fatty acid biosynthetic process
L1776_RS09210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1776_RS09215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L1776_RS09225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L1776_RS09230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L1776_RS09245	COG0084	hydrolase, TatD family'
L1776_RS09250	COG1113	amino acid transport
L1776_RS09310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1776_RS09320	COG5001	Diguanylate cyclase
L1776_RS09320	COG3300	MHYT domain
L1776_RS09335	COG2130	NADP-dependent
L1776_RS09360	COG0583	DNA-binding transcription factor activity
L1776_RS09385	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L1776_RS09390	COG2226	methyltransferase
L1776_RS09400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L1776_RS09405	COG0583	DNA-binding transcription factor activity
L1776_RS09410	COG1943	Transposase
L1776_RS09425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1776_RS09435	COG0745	RESPONSE REGULATOR receiver
L1776_RS09440	COG2205	protein histidine kinase activity
L1776_RS09450	COG0668	transmembrane transport
L1776_RS09485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L1776_RS09495	COG2988	succinylglutamate desuccinylase activity
L1776_RS09500	COG1131	(ABC) transporter
L1776_RS09505	COG0842	Transport permease protein
L1776_RS09520	COG2853	Lipoprotein
L1776_RS09530	COG0745	RESPONSE REGULATOR receiver
L1776_RS09540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L1776_RS09560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L1776_RS09595	COG2814	Major facilitator Superfamily
L1776_RS09600	COG4948	Mandelate Racemase Muconate Lactonizing
L1776_RS09605	COG4829	muconolactone delta-isomerase
L1776_RS09610	COG3485	protocatechuate 3,4-dioxygenase
L1776_RS09615	COG3135	benzoate transporter
L1776_RS09650	COG4191	Histidine kinase
L1776_RS09650	COG0784	Response regulator, receiver
L1776_RS09660	COG0114	fumarate hydratase activity
L1776_RS09670	COG0271	Belongs to the BolA IbaG family
L1776_RS09675	COG1054	Belongs to the UPF0176 family
L1776_RS09690	COG0840	transmembrane signaling receptor activity
L1776_RS09715	COG0583	DNA-binding transcription factor activity
L1776_RS09720	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
L1776_RS09725	COG1960	acyl-CoA dehydrogenase activity
L1776_RS09735	COG2079	MmgE PrpD family protein
L1776_RS09745	COG2301	Belongs to the HpcH HpaI aldolase family
L1776_RS09805	COG3755	Protein conserved in bacteria
L1776_RS09810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1776_RS09815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1776_RS09835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L1776_RS09845	COG1770	oligopeptidase
L1776_RS09850	COG1024	Enoyl-CoA hydratase
L1776_RS09850	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1776_RS09855	COG0183	Belongs to the thiolase family
L1776_RS09920	COG0653	protein targeting
L1776_RS09940	COG0133	tryptophan synthase activity
L1776_RS09945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L1776_RS09950	COG1012	belongs to the aldehyde dehydrogenase family
L1776_RS09955	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
L1776_RS09960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L1776_RS09985	COG0297	glycogen (starch) synthase activity
L1776_RS10015	COG0250	Participates in transcription elongation, termination and antitermination
L1776_RS10075	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS10090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L1776_RS10095	COG0066	3-isopropylmalate dehydratase activity
L1776_RS10125	COG0135	phosphoribosylanthranilate isomerase activity
L1776_RS10130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L1776_RS10135	COG0285	dihydrofolate synthase activity
L1776_RS10140	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L1776_RS10145	COG1286	toxin biosynthetic process
L1776_RS10180	COG0789	Transcriptional regulator
L1776_RS10210	COG4771	TonB-dependent receptor
L1776_RS10215	COG0254	rRNA binding
L1776_RS10230	COG0477	Major facilitator Superfamily
L1776_RS10240	COG0655	NAD(P)H dehydrogenase (quinone) activity
L1776_RS10245	COG2814	Major facilitator Superfamily
L1776_RS10270	COG1271	oxidase subunit
L1776_RS10275	COG1294	oxidase, subunit
L1776_RS10295	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1776_RS10295	COG1902	pentaerythritol trinitrate reductase activity
L1776_RS10325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1776_RS10335	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L1776_RS10340	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L1776_RS10355	COG0573	inorganic phosphate transmembrane transporter activity
L1776_RS10370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L1776_RS10375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L1776_RS10385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L1776_RS10415	COG2010	Cytochrome c
L1776_RS10430	COG3278	Belongs to the heme-copper respiratory oxidase family
L1776_RS10435	COG2010	Cytochrome c
L1776_RS10445	COG3278	Belongs to the heme-copper respiratory oxidase family
L1776_RS10455	COG0840	transmembrane signaling receptor activity
L1776_RS10465	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
L1776_RS10485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L1776_RS10490	COG2010	Cytochrome c
L1776_RS10490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L1776_RS10505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L1776_RS10510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L1776_RS10520	COG3115	cell septum assembly
L1776_RS10525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L1776_RS10555	COG3123	guanosine phosphorylase activity
L1776_RS10575	COG2009	succinate dehydrogenase
L1776_RS10580	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L1776_RS10585	COG1053	succinate dehydrogenase
L1776_RS10590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L1776_RS10610	COG0045	succinate-CoA ligase (ADP-forming) activity
L1776_RS10645	COG0326	Molecular chaperone. Has ATPase activity
L1776_RS10675	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
L1776_RS10685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L1776_RS10690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L1776_RS10725	COG0628	permease
L1776_RS10735	COG0709	Synthesizes selenophosphate from selenide and ATP
L1776_RS10740	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
L1776_RS10750	COG0714	Associated with various cellular activities
L1776_RS10775	COG1238	metal cluster binding
L1776_RS10790	COG0183	Belongs to the thiolase family
L1776_RS10795	COG1960	acyl-CoA dehydrogenase activity
L1776_RS10800	COG0318	PFAM AMP-dependent synthetase and ligase
L1776_RS10805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1776_RS10815	COG1960	acyl-CoA dehydrogenase activity
L1776_RS10820	COG1024	Enoyl-CoA hydratase
L1776_RS10855	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L1776_RS10870	COG2205	protein histidine kinase activity
L1776_RS10875	COG0745	RESPONSE REGULATOR receiver
L1776_RS10880	COG0058	SHG alpha-glucan phosphorylase activity
L1776_RS10910	COG4991	sh3 domain protein
L1776_RS10915	COG4191	Histidine kinase
L1776_RS10915	COG0784	Response regulator, receiver
L1776_RS10920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L1776_RS10940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L1776_RS10955	COG5002	protein histidine kinase activity
L1776_RS10955	COG3447	MASE1 domain protein
L1776_RS10955	COG5001	Diguanylate cyclase
L1776_RS11000	COG0210	DNA helicase
L1776_RS11005	COG0515	serine threonine protein kinase
L1776_RS11015	COG2146	nitrite reductase [NAD(P)H] activity
L1776_RS11015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1776_RS11020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1776_RS11020	COG2146	nitrite reductase [NAD(P)H] activity
L1776_RS11035	COG0840	transmembrane signaling receptor activity
L1776_RS11040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L1776_RS11055	COG4221	oxidoreductase activity
L1776_RS11065	COG0415	Belongs to the DNA photolyase family
L1776_RS11070	COG0789	Transcriptional regulator
L1776_RS11075	COG3272	Protein of unknown function (DUF1722)
L1776_RS11080	COG1090	epimerase
L1776_RS11085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L1776_RS11095	COG1366	Belongs to the anti-sigma-factor antagonist family
L1776_RS11115	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L1776_RS11120	COG0302	gtp cyclohydrolase
L1776_RS11130	COG0789	Transcriptional regulator
L1776_RS11135	COG1025	Belongs to the peptidase M16 family
L1776_RS11150	COG2205	protein histidine kinase activity
L1776_RS11150	COG0784	Response regulator, receiver
L1776_RS11155	COG0435	Glutathione S-transferase
L1776_RS11160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L1776_RS11165	COG2920	part of a sulfur-relay system
L1776_RS11215	COG0174	glutamine synthetase
L1776_RS11220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1776_RS11225	COG1116	anion transmembrane transporter activity
L1776_RS11230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1776_RS11240	COG1335	isochorismatase
L1776_RS11260	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS11270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1776_RS11285	COG4770	biotin carboxylase activity
L1776_RS11295	COG3665	Urea carboxylase-associated protein
L1776_RS11300	COG3842	ATPase activity
L1776_RS11315	COG0084	hydrolase, TatD family'
L1776_RS11320	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L1776_RS11340	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L1776_RS11345	COG4181	ATPase activity
L1776_RS11375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L1776_RS11380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L1776_RS11395	COG0560	Phosphoserine phosphatase
L1776_RS11420	COG1802	Transcriptional regulator
L1776_RS11430	COG0372	Belongs to the citrate synthase family
L1776_RS11445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
L1776_RS11455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L1776_RS11470	COG0668	transmembrane transport
L1776_RS11505	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1776_RS11510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L1776_RS11515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L1776_RS11520	COG0215	cysteine-tRNA ligase activity
L1776_RS11525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L1776_RS11545	COG2186	Transcriptional regulator
L1776_RS11555	COG0544	peptidyl-prolyl cis-trans isomerase activity
L1776_RS11565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L1776_RS11570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L1776_RS11585	COG0167	dihydroorotate dehydrogenase activity
L1776_RS11590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L1776_RS11630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L1776_RS11635	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
L1776_RS11645	COG0535	radical SAM domain protein
L1776_RS11660	COG5002	protein histidine kinase activity
L1776_RS11675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L1776_RS11680	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1776_RS11735	COG0798	PFAM Bile acid sodium symporter
L1776_RS11740	COG2072	flavoprotein involved in K transport
L1776_RS11745	COG0640	Transcriptional regulator
L1776_RS11750	COG0431	NADPH-dependent FMN reductase
L1776_RS11760	COG1742	UPF0060 membrane protein
L1776_RS11765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L1776_RS11790	COG5642	Protein of unknown function (DUF2384)
L1776_RS11900	COG1598	PFAM Uncharacterised protein family UPF0150
L1776_RS11950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L1776_RS12065	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1776_RS12075	COG0583	DNA-binding transcription factor activity
L1776_RS12180	COG1566	PFAM secretion protein HlyD family protein
L1776_RS12190	COG0583	DNA-binding transcription factor activity
L1776_RS12205	COG0723	plastoquinol--plastocyanin reductase activity
L1776_RS12210	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS12215	COG0028	Belongs to the TPP enzyme family
L1776_RS12240	COG3685	Protein conserved in bacteria
L1776_RS12245	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
L1776_RS12245	COG3264	Mechanosensitive ion channel
L1776_RS12250	COG1058	Belongs to the CinA family
L1776_RS12250	COG1546	Belongs to the CinA family
L1776_RS12255	COG0297	glycogen (starch) synthase activity
L1776_RS12260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1776_RS12285	COG0739	heme binding
L1776_RS12295	COG3384	dioxygenase
L1776_RS12300	COG0583	DNA-binding transcription factor activity
L1776_RS12315	COG3568	Endonuclease Exonuclease Phosphatase
L1776_RS12320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1776_RS12325	COG0392	lysyltransferase activity
L1776_RS12330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1776_RS12335	COG0366	Alpha amylase catalytic
L1776_RS12355	COG2864	formate dehydrogenase
L1776_RS12360	COG0437	4 iron, 4 sulfur cluster binding
L1776_RS12380	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS12385	COG0604	alcohol dehydrogenase
L1776_RS12385	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS12385	COG3321	synthase
L1776_RS12435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L1776_RS12445	COG0728	peptidoglycan biosynthetic process
L1776_RS12460	COG1115	amino acid carrier protein
L1776_RS12470	COG0729	surface antigen
L1776_RS12505	COG1175	transmembrane transport
L1776_RS12525	COG1070	Carbohydrate kinase
L1776_RS12540	COG1609	Transcriptional regulator
L1776_RS12545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L1776_RS12550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
L1776_RS12555	COG3265	gluconokinase activity
L1776_RS12560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L1776_RS12565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L1776_RS12590	COG0488	(ABC) transporter
L1776_RS12595	COG1968	undecaprenyl-diphosphatase activity
L1776_RS12600	COG0840	transmembrane signaling receptor activity
L1776_RS12615	COG2323	membrane
L1776_RS12630	COG3706	GGDEF domain
L1776_RS12635	COG2201	protein-glutamate methylesterase activity
L1776_RS12640	COG0316	Belongs to the HesB IscA family
L1776_RS12640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L1776_RS12660	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L1776_RS12660	COG2755	lipolytic protein G-D-S-L family
L1776_RS12685	COG2223	nitrite transmembrane transporter activity
L1776_RS12690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L1776_RS12705	COG0071	Belongs to the small heat shock protein (HSP20) family
L1776_RS12725	COG0604	alcohol dehydrogenase
L1776_RS12730	COG0616	signal peptide processing
L1776_RS12750	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS12765	COG2816	NAD+ diphosphatase activity
L1776_RS12775	COG1024	Enoyl-CoA hydratase
L1776_RS12785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L1776_RS12790	COG0328	RNA-DNA hybrid ribonuclease activity
L1776_RS12800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1776_RS12805	COG1388	LysM domain
L1776_RS12805	COG0741	lytic transglycosylase activity
L1776_RS12815	COG4166	transmembrane transport
L1776_RS12825	COG4174	ABC transporter (Permease)
L1776_RS12830	COG4239	(ABC) transporter, permease
L1776_RS12835	COG4172	Belongs to the ABC transporter superfamily
L1776_RS12925	COG0840	transmembrane signaling receptor activity
L1776_RS12945	COG1131	(ABC) transporter
L1776_RS12965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L1776_RS12965	COG1648	precorrin-2 dehydrogenase activity
L1776_RS12970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L1776_RS12975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L1776_RS12980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L1776_RS12985	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L1776_RS12995	COG0492	ferredoxin-NADP+ reductase activity
L1776_RS13000	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L1776_RS13005	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
L1776_RS13010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L1776_RS13015	COG0542	response to heat
L1776_RS13020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L1776_RS13045	COG0482	sulfurtransferase activity
L1776_RS13050	COG2915	High frequency lysogenization protein hflD homolog
L1776_RS13060	COG2850	peptidyl-arginine hydroxylation
L1776_RS13065	COG2153	protein acetylation
L1776_RS13090	COG0628	permease
L1776_RS13095	COG2056	Na+-H+ antiporter family
L1776_RS13100	COG0720	synthase
L1776_RS13130	COG0402	S-adenosylhomocysteine deaminase activity
L1776_RS13135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L1776_RS13140	COG0546	phosphoglycolate phosphatase activity
L1776_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS13155	COG0800	Aldolase
L1776_RS13180	COG2840	Smr protein MutS2
L1776_RS13190	COG0625	glutathione transferase activity
L1776_RS13195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1776_RS13210	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L1776_RS13215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L1776_RS13225	COG0077	Prephenate dehydratase
L1776_RS13225	COG1605	Chorismate mutase
L1776_RS13230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L1776_RS13240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L1776_RS13255	COG0587	DNA-directed DNA polymerase activity
L1776_RS13275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1776_RS13280	COG0765	amino acid transport
L1776_RS13285	COG1126	abc transporter atp-binding protein
L1776_RS13290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1776_RS13320	COG0745	RESPONSE REGULATOR receiver
L1776_RS13410	COG3012	SEC-C Motif Domain Protein
L1776_RS13465	COG5377	YqaJ viral recombinase family
L1776_RS13490	COG2003	Belongs to the UPF0758 family
L1776_RS13510	COG0084	hydrolase, TatD family'
L1776_RS13540	COG0776	regulation of translation
L1776_RS13545	COG0072	phenylalanine-tRNA ligase activity
L1776_RS13550	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L1776_RS13555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L1776_RS13560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L1776_RS13570	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L1776_RS13580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1776_RS13655	COG3171	Protein conserved in bacteria
L1776_RS13660	COG2027	D-alanyl-D-alanine carboxypeptidase
L1776_RS13665	COG0116	Belongs to the methyltransferase superfamily
L1776_RS13665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L1776_RS13670	COG3130	regulation of translation
L1776_RS13675	COG0167	dihydroorotate dehydrogenase activity
L1776_RS13695	COG0714	Associated with various cellular activities
L1776_RS13715	COG2304	oxidoreductase activity
L1776_RS13725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1776_RS13730	COG3707	response regulator
L1776_RS13750	COG2223	nitrite transmembrane transporter activity
L1776_RS13755	COG0515	serine threonine protein kinase
L1776_RS13755	COG2815	serine threonine protein kinase
L1776_RS13765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1776_RS13770	COG2146	nitrite reductase [NAD(P)H] activity
L1776_RS13775	COG0243	molybdopterin cofactor binding
L1776_RS13795	COG0308	aminopeptidase N
L1776_RS13815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L1776_RS13820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L1776_RS13835	COG0730	response to heat
L1776_RS13850	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L1776_RS13875	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
L1776_RS13890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L1776_RS13905	COG4580	involved in the transport of maltose and maltodextrins
L1776_RS13910	COG3842	ATPase activity
L1776_RS13915	COG0395	ABC-type sugar transport system, permease component
L1776_RS13920	COG1175	transmembrane transport
L1776_RS13925	COG1653	transport
L1776_RS13950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L1776_RS13960	COG0180	Tryptophanyl-tRNA synthetase
L1776_RS13965	COG0009	L-threonylcarbamoyladenylate synthase
L1776_RS13970	COG0613	PHP domain protein
L1776_RS13975	COG2350	Protein conserved in bacteria
L1776_RS13985	COG0745	RESPONSE REGULATOR receiver
L1776_RS14000	COG0778	Nitroreductase
L1776_RS14005	COG0727	PFAM Uncharacterised protein family (UPF0153)
L1776_RS14010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L1776_RS14015	COG2354	Protein conserved in bacteria
L1776_RS14050	COG1752	Esterase of the alpha-beta hydrolase superfamily
L1776_RS14060	COG0514	ATP-dependent DNA helicase (RecQ)
L1776_RS14070	COG2832	Protein of unknown function (DUF454)
L1776_RS14080	COG0625	glutathione transferase activity
L1776_RS14085	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
L1776_RS14095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L1776_RS14105	COG0542	response to heat
L1776_RS14125	COG0121	glutamine amidotransferase
L1776_RS14135	COG0589	response to stress
L1776_RS14145	COG0488	(ABC) transporter
L1776_RS14150	COG0741	lytic transglycosylase activity
L1776_RS14155	COG0633	Ferredoxin
L1776_RS14155	COG3217	Mosc domain protein beta barrel domain protein
L1776_RS14160	COG3437	response regulator, receiver
L1776_RS14170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L1776_RS14175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L1776_RS14180	COG3206	protein involved in exopolysaccharide biosynthesis
L1776_RS14180	COG0489	protein tyrosine kinase activity
L1776_RS14185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1776_RS14225	COG0183	Belongs to the thiolase family
L1776_RS14235	COG2977	Belongs to the P-Pant transferase superfamily
L1776_RS14250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L1776_RS14275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1776_RS14285	COG1216	Glycosyl transferase, family 2
L1776_RS14310	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
L1776_RS14330	COG0543	2 iron, 2 sulfur cluster binding
L1776_RS14330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L1776_RS14345	COG0776	regulation of translation
L1776_RS14355	COG0840	transmembrane signaling receptor activity
L1776_RS14360	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L1776_RS14365	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L1776_RS14370	COG0471	metal ion transport
L1776_RS14375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L1776_RS14400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L1776_RS14410	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L1776_RS14445	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
L1776_RS14470	COG4591	ABC-type transport system involved in lipoprotein release permease component
L1776_RS14475	COG1136	(ABC) transporter
L1776_RS14485	COG3453	Protein conserved in bacteria
L1776_RS14485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1776_RS14515	COG0640	Transcriptional regulator
L1776_RS14550	COG0386	Belongs to the glutathione peroxidase family
L1776_RS14555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1776_RS14560	COG0436	Aminotransferase
L1776_RS14570	COG0501	Belongs to the peptidase M48B family
L1776_RS14580	COG0500	methyltransferase
L1776_RS14630	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
L1776_RS14660	COG2257	FlhB HrpN YscU SpaS Family
L1776_RS14675	COG0835	chemotaxis
L1776_RS14685	COG1192	Involved in chromosome partitioning
L1776_RS14690	COG1360	Flagellar Motor Protein
L1776_RS14695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L1776_RS14700	COG2201	protein-glutamate methylesterase activity
L1776_RS14705	COG0784	Response regulator, receiver
L1776_RS14705	COG0643	Histidine kinase
L1776_RS14705	COG2198	Histidine kinase
L1776_RS14710	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
L1776_RS14740	COG2032	superoxide dismutase activity
L1776_RS14755	COG1987	bacterial-type flagellum assembly
L1776_RS14790	COG0643	Histidine kinase
L1776_RS14790	COG2198	Histidine kinase
L1776_RS14795	COG0745	RESPONSE REGULATOR receiver
L1776_RS14830	COG1677	Flagellar hook-basal body complex protein FliE
L1776_RS14835	COG3135	benzoate transporter
L1776_RS14845	COG0789	Transcriptional regulator
L1776_RS14850	COG2188	Transcriptional regulator
L1776_RS14865	COG0840	transmembrane signaling receptor activity
L1776_RS14895	COG0826	peptidase U32
L1776_RS14940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L1776_RS14955	COG1283	sodium-dependent phosphate transmembrane transporter activity
L1776_RS14965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L1776_RS14970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L1776_RS15015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1776_RS15020	COG0004	ammonium transporteR
L1776_RS15035	COG2258	MOSC domain
L1776_RS15045	COG0217	transcriptional regulatory protein
L1776_RS15055	COG0589	response to stress
L1776_RS15110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L1776_RS15115	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L1776_RS15120	COG0585	pseudouridine synthase activity
L1776_RS15125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L1776_RS15135	COG1902	pentaerythritol trinitrate reductase activity
L1776_RS15140	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L1776_RS15150	COG0583	DNA-binding transcription factor activity
L1776_RS15165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L1776_RS15180	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L1776_RS15185	COG0504	CTP synthase activity
L1776_RS15190	COG0037	tRNA processing
L1776_RS15195	COG0825	malonyl-CoA metabolic process
L1776_RS15205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L1776_RS15210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1776_RS15215	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1776_RS15220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L1776_RS15225	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1776_RS15235	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L1776_RS15245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L1776_RS15255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L1776_RS15260	COG0233	cytoplasmic translational termination
L1776_RS15265	COG0528	UMP kinase activity
L1776_RS15270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L1776_RS15275	COG0052	Belongs to the universal ribosomal protein uS2 family
L1776_RS15280	COG0024	Methionine aminopeptidase
L1776_RS15285	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L1776_RS15290	COG1320	monovalent cation:proton antiporter activity
L1776_RS15295	COG2212	antiporter activity
L1776_RS15300	COG1863	multisubunit Na H antiporter MnhE subunit
L1776_RS15305	COG0651	ATP synthesis coupled electron transport
L1776_RS15310	COG1006	Multisubunit Na H antiporter MnhC subunit
L1776_RS15315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L1776_RS15315	COG2111	Na H antiporter
L1776_RS15330	COG0259	pyridoxamine-phosphate oxidase activity
L1776_RS15340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L1776_RS15345	COG1199	ATP-dependent helicase activity
L1776_RS15365	COG3012	SEC-C Motif Domain Protein
L1776_RS15375	COG0583	DNA-binding transcription factor activity
L1776_RS15385	COG0697	spore germination
L1776_RS15390	COG3148	PFAM DTW domain containing protein
L1776_RS15400	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
L1776_RS15405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L1776_RS15415	COG2137	regulation of response to DNA damage stimulus
L1776_RS15420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L1776_RS15425	COG1546	Belongs to the CinA family
L1776_RS15435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L1776_RS15440	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L1776_RS15460	COG0438	transferase activity, transferring glycosyl groups
L1776_RS15465	COG1295	ribonuclease BN
L1776_RS15475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1776_RS15515	COG0784	Response regulator, receiver
L1776_RS15515	COG2198	Histidine kinase
L1776_RS15515	COG5002	protein histidine kinase activity
L1776_RS15550	COG0745	RESPONSE REGULATOR receiver
L1776_RS15550	COG2205	protein histidine kinase activity
L1776_RS15550	COG3292	Two component regulator propeller
L1776_RS15570	COG3093	addiction module antidote protein HigA
L1776_RS15625	COG4974	Belongs to the 'phage' integrase family
L1776_RS15650	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
L1776_RS15665	COG2996	Protein conserved in bacteria
L1776_RS15670	COG4993	Dehydrogenase
L1776_RS15675	COG2133	pyrroloquinoline quinone binding
L1776_RS15710	COG1201	RNA secondary structure unwinding
L1776_RS15720	COG4221	oxidoreductase activity
L1776_RS15730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L1776_RS15740	COG4935	Belongs to the peptidase S8 family
L1776_RS15740	COG1404	Belongs to the peptidase S8 family
L1776_RS15750	COG0367	asparagine synthase
L1776_RS15755	COG0189	ligase activity
L1776_RS15755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L1776_RS15760	COG1363	Peptidase, m42
L1776_RS15770	COG3089	Belongs to the UPF0270 family
L1776_RS15790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1776_RS15795	COG3162	membrane
L1776_RS15810	COG2853	Lipoprotein
L1776_RS15820	COG1560	Kdo2-lipid A biosynthetic process
L1776_RS15825	COG0850	regulation of cytokinetic process
L1776_RS15830	COG2894	cell division
L1776_RS15835	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
L1776_RS15840	COG0564	pseudouridine synthase activity
L1776_RS15850	COG1362	aminopeptidase activity
L1776_RS15865	COG2200	EAL domain
L1776_RS15890	COG1555	photosystem II stabilization
L1776_RS15900	COG1256	bacterial-type flagellum assembly
L1776_RS15910	COG1706	bacterial-type flagellum-dependent cell motility
L1776_RS15915	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
L1776_RS15920	COG4786	Flagellar basal body rod
L1776_RS15925	COG4787	bacterial-type flagellum-dependent cell motility
L1776_RS15945	COG1815	bacterial-type flagellum-dependent cell motility
L1776_RS15950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L1776_RS15955	COG0835	chemotaxis
L1776_RS15955	COG0784	Response regulator, receiver
L1776_RS15975	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
L1776_RS16000	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
L1776_RS16010	COG3630	sodium ion export across plasma membrane
L1776_RS16015	COG2239	Acts as a magnesium transporter
L1776_RS16040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L1776_RS16045	COG0527	aspartate kinase activity
L1776_RS16050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L1776_RS16065	COG2983	Belongs to the UPF0260 family
L1776_RS16075	COG3100	YcgL domain-containing protein
L1776_RS16090	COG2067	long-chain fatty acid transport protein
L1776_RS16120	COG0251	oxidation-reduction process
L1776_RS16130	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L1776_RS16140	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L1776_RS16150	COG1492	cobalamin metabolic process
L1776_RS16160	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L1776_RS16170	COG0778	Nitroreductase
L1776_RS16175	COG1797	cobyrinic acid a,c-diamide synthase activity
L1776_RS16190	COG4206	TonB-dependent receptor
L1776_RS16205	COG0791	NLP P60 protein
L1776_RS16210	COG0791	NLP P60 protein
L1776_RS16235	COG1294	oxidase, subunit
L1776_RS16260	COG2818	Glycosylase
L1776_RS16265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L1776_RS16270	COG0037	tRNA processing
L1776_RS16295	COG2814	Major facilitator Superfamily
L1776_RS16300	COG4459	periplasmic nitrate reductase
L1776_RS16310	COG0243	molybdopterin cofactor binding
L1776_RS16320	COG3005	denitrification pathway
L1776_RS16325	COG0717	Belongs to the dCTP deaminase family
L1776_RS16330	COG1278	Cold shock
L1776_RS16335	COG0489	protein tyrosine kinase activity
L1776_RS16340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1776_RS16340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1776_RS16365	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
L1776_RS16465	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1776_RS16470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1776_RS16485	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L1776_RS16490	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L1776_RS16495	COG1414	Transcriptional regulator
L1776_RS16500	COG0679	Auxin Efflux Carrier
L1776_RS16505	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L1776_RS16510	COG3485	protocatechuate 3,4-dioxygenase
L1776_RS16515	COG3485	protocatechuate 3,4-dioxygenase
L1776_RS16520	COG0583	DNA-binding transcription factor activity
L1776_RS16530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1776_RS16545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1776_RS16560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L1776_RS16570	COG2226	methyltransferase
L1776_RS16575	COG0500	methyltransferase
L1776_RS16585	COG0583	DNA-binding transcription factor activity
L1776_RS16595	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L1776_RS16600	COG1381	Involved in DNA repair and RecF pathway recombination
L1776_RS16610	COG0571	ribonuclease III activity
L1776_RS16625	COG0481	GTPase activity
L1776_RS16630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1776_RS16670	COG0354	folic acid binding
L1776_RS16685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L1776_RS16695	COG1024	Enoyl-CoA hydratase
L1776_RS16710	COG4657	Part of a membrane complex involved in electron transport
L1776_RS16715	COG2878	Part of a membrane complex involved in electron transport
L1776_RS16725	COG4658	electron transport chain
L1776_RS16730	COG4659	FMN binding
L1776_RS16740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L1776_RS16750	COG0346	lactoylglutathione lyase activity
L1776_RS16755	COG0137	argininosuccinate synthase activity
L1776_RS16765	COG0418	dihydroorotase activity
L1776_RS16770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L1776_RS16785	COG3791	Glutathione-dependent formaldehyde-activating
L1776_RS16800	COG0335	large ribosomal subunit rRNA binding
L1776_RS16805	COG0336	Belongs to the RNA methyltransferase TrmD family
L1776_RS16810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L1776_RS16815	COG0228	four-way junction DNA binding
L1776_RS16820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L1776_RS16825	COG4137	Cytochrome C assembly protein
L1776_RS16830	COG4536	flavin adenine dinucleotide binding
L1776_RS16835	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
L1776_RS16860	COG3034	peptidoglycan biosynthetic process
L1776_RS16870	COG0047	phosphoribosylformylglycinamidine synthase activity
L1776_RS16870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L1776_RS16875	COG1126	abc transporter atp-binding protein
L1776_RS16880	COG0765	amino acid transport
L1776_RS16885	COG4597	amino acid ABC transporter
L1776_RS16890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1776_RS16895	COG0400	carboxylic ester hydrolase activity
L1776_RS16915	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L1776_RS16920	COG0315	cyclic pyranopterin monophosphate synthase activity
L1776_RS16925	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L1776_RS16935	COG3022	response to hydroperoxide
L1776_RS16950	COG0433	COG0433 Predicted ATPase
L1776_RS16960	COG0788	formyltetrahydrofolate deformylase activity
L1776_RS16970	COG2925	Exonuclease
L1776_RS16995	COG0714	Associated with various cellular activities
L1776_RS17020	COG0469	pyruvate kinase activity
L1776_RS17040	COG4628	conserved protein (DUF2132)
L1776_RS17045	COG0693	protein deglycase activity
L1776_RS17050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1776_RS17090	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS17095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L1776_RS17110	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
L1776_RS17125	COG1309	transcriptional regulator
L1776_RS17130	COG0386	Belongs to the glutathione peroxidase family
L1776_RS17140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L1776_RS17150	COG0204	Acyl-transferase
L1776_RS17160	COG0784	Response regulator, receiver
L1776_RS17160	COG2205	protein histidine kinase activity
L1776_RS17165	COG2885	chlorophyll binding
L1776_RS17170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1776_RS17175	COG4191	Histidine kinase
L1776_RS17175	COG0784	Response regulator, receiver
L1776_RS17180	COG0318	PFAM AMP-dependent synthetase and ligase
L1776_RS17185	COG1280	lysine exporter protein (LysE YggA)
L1776_RS17190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L1776_RS17195	COG2813	Specifically methylates the guanine in position
L1776_RS17200	COG2119	membrane
L1776_RS17210	COG0501	Belongs to the peptidase M48B family
L1776_RS17270	COG0659	secondary active sulfate transmembrane transporter activity
L1776_RS17275	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS17300	COG1285	pathogenesis
L1776_RS17345	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1776_RS17350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L1776_RS17355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L1776_RS17360	COG0772	Belongs to the SEDS family
L1776_RS17365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L1776_RS17370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L1776_RS17375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L1776_RS17380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L1776_RS17395	COG0275	rRNA processing
L1776_RS17420	COG0792	nuclease activity
L1776_RS17425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L1776_RS17430	COG2823	Periplasmic or secreted lipoprotein
L1776_RS17435	COG2969	positive regulation of protein catabolic process
L1776_RS17440	COG0625	glutathione transferase activity
L1776_RS17445	COG2857	Cytochrome c1
L1776_RS17450	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L1776_RS17455	COG0723	plastoquinol--plastocyanin reductase activity
L1776_RS17460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L1776_RS17465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L1776_RS17470	COG0667	Aldo Keto reductase
L1776_RS17485	COG0237	dephospho-CoA kinase activity
L1776_RS17490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L1776_RS17530	COG0175	sulfate reduction
L1776_RS17540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1776_RS17545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1776_RS17555	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L1776_RS17560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L1776_RS17585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L1776_RS17590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1776_RS17595	COG1127	ABC transporter
L1776_RS17605	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L1776_RS17620	COG1137	ATPase activity
L1776_RS17625	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L1776_RS17640	COG1660	Displays ATPase and GTPase activities
L1776_RS17645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1776_RS17650	COG0312	modulator of DNA gyrase
L1776_RS17660	COG0312	modulator of DNA gyrase
L1776_RS17665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1776_RS17675	COG1530	ribonuclease E activity
L1776_RS17695	COG1792	Involved in formation and maintenance of cell shape
L1776_RS17700	COG1077	Cell shape determining protein MreB Mrl
L1776_RS17705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L1776_RS17715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L1776_RS17730	COG0530	calcium, potassium:sodium antiporter activity
L1776_RS17745	COG0739	heme binding
L1776_RS17755	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
L1776_RS17770	COG4771	TonB-dependent receptor
L1776_RS17790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L1776_RS17795	COG4774	siderophore transport
L1776_RS17800	COG3128	pkhd-type hydroxylase
L1776_RS17810	COG0019	diaminopimelate decarboxylase activity
L1776_RS17815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L1776_RS17820	COG2852	Protein conserved in bacteria
L1776_RS17825	COG4993	Dehydrogenase
L1776_RS17830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1776_RS17830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L1776_RS17830	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L1776_RS17835	COG1105	Belongs to the carbohydrate kinase PfkB family
L1776_RS17840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L1776_RS17840	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1776_RS17855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L1776_RS17885	COG0534	Mate efflux family protein
L1776_RS17900	COG0023	Translation Initiation Factor
L1776_RS17905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1776_RS17910	COG4968	Prepilin-type N-terminal cleavage methylation domain
L1776_RS17945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L1776_RS17950	COG1047	Peptidyl-prolyl cis-trans
L1776_RS17955	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L1776_RS17960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L1776_RS17965	COG0196	riboflavin kinase activity
L1776_RS17975	COG0268	Binds directly to 16S ribosomal RNA
L1776_RS17980	COG3045	CreA protein
L1776_RS17985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L1776_RS17990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L1776_RS17995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L1776_RS18000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L1776_RS18005	COG0142	geranyltranstransferase activity
L1776_RS18015	COG0545	Peptidyl-prolyl cis-trans isomerase
L1776_RS18035	COG2862	Uncharacterized protein family, UPF0114
L1776_RS18045	COG1067	ATP-dependent peptidase activity
L1776_RS18055	COG1970	mechanosensitive ion channel activity
L1776_RS18060	COG2841	Protein conserved in bacteria
L1776_RS18080	COG2020	methyltransferase activity
L1776_RS18085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L1776_RS18090	COG0488	(ABC) transporter
L1776_RS18125	COG2813	Specifically methylates the guanine in position
L1776_RS18130	COG0789	Transcriptional regulator
L1776_RS18155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1776_RS18160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L1776_RS18165	COG2080	2 iron, 2 sulfur cluster binding
L1776_RS18170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L1776_RS18175	COG3608	succinylglutamate desuccinylase aspartoacylase
L1776_RS18175	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L1776_RS18185	COG2252	PERMEase
L1776_RS18190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L1776_RS18200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L1776_RS18215	COG1368	sulfuric ester hydrolase activity
L1776_RS18225	COG3642	lipopolysaccharide core region biosynthetic process
L1776_RS18235	COG0642	Histidine kinase
L1776_RS18245	COG1368	sulfuric ester hydrolase activity
L1776_RS18300	COG3038	cytochrome b561
L1776_RS18310	COG0521	Mo-molybdopterin cofactor biosynthetic process
L1776_RS18320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L1776_RS18325	COG2181	nitrate reductase activity
L1776_RS18330	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
L1776_RS18335	COG1140	nitrate reductase beta subunit
L1776_RS18340	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
L1776_RS18345	COG2223	nitrite transmembrane transporter activity
L1776_RS18355	COG2223	nitrite transmembrane transporter activity
L1776_RS18360	COG3850	Histidine kinase
L1776_RS18365	COG2197	response regulator
L1776_RS18390	COG2321	neutral zinc metallopeptidase
L1776_RS18400	COG1946	Acyl-CoA thioesterase
L1776_RS18410	COG0123	including yeast histone deacetylase and acetoin utilization protein
L1776_RS18435	COG0513	Belongs to the DEAD box helicase family
L1776_RS18440	COG4651	solute:proton antiporter activity
L1776_RS18440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L1776_RS18460	COG0733	neurotransmitter:sodium symporter activity
L1776_RS18465	COG0625	glutathione transferase activity
L1776_RS18475	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L1776_RS18485	COG0733	neurotransmitter:sodium symporter activity
L1776_RS18500	COG1522	sequence-specific DNA binding
L1776_RS18510	COG2031	fatty acid transporter
L1776_RS18515	COG2610	gluconate transmembrane transporter activity
L1776_RS18520	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS18525	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L1776_RS18530	COG1040	competence protein
L1776_RS18590	COG0420	3'-5' exonuclease activity
L1776_RS18600	COG4206	TonB-dependent receptor
L1776_RS18615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1776_RS18620	COG3577	Aspartyl protease
L1776_RS18625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L1776_RS18635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L1776_RS18640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L1776_RS18655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1776_RS18655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1776_RS18670	COG2264	protein methyltransferase activity
L1776_RS18680	COG0425	Belongs to the sulfur carrier protein TusA family
L1776_RS18685	COG2391	methyltransferase activity
L1776_RS18690	COG3118	belongs to the thioredoxin family
L1776_RS18705	COG1136	(ABC) transporter
L1776_RS18730	COG0848	biopolymer transport protein
L1776_RS18735	COG0811	peptide transport
L1776_RS18740	COG0811	peptide transport
L1776_RS18750	COG3047	cAMP biosynthetic process
L1776_RS18770	COG2814	Major facilitator Superfamily
L1776_RS18785	COG0203	ribosomal protein L17
L1776_RS18790	COG0202	RNA polymerase activity
L1776_RS18795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L1776_RS18800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L1776_RS18805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L1776_RS18810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L1776_RS18820	COG0200	Binds to the 23S rRNA
L1776_RS18825	COG1841	ribosomal large subunit assembly
L1776_RS18830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L1776_RS18840	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L1776_RS18845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L1776_RS18850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L1776_RS18855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L1776_RS18860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L1776_RS18865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L1776_RS18870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L1776_RS18875	COG0255	Belongs to the universal ribosomal protein uL29 family
L1776_RS18880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L1776_RS18885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L1776_RS18890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L1776_RS18895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L1776_RS18900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L1776_RS18905	COG0089	rRNA binding
L1776_RS18910	COG0088	Forms part of the polypeptide exit tunnel
L1776_RS18915	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L1776_RS18920	COG0051	transcription antitermination factor activity, RNA binding
L1776_RS18925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L1776_RS18930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L1776_RS18935	COG0049	tRNA binding
L1776_RS18940	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L1776_RS18945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L1776_RS18950	COG0085	RNA polymerase activity
L1776_RS18955	COG0222	ribosome binding
L1776_RS18960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L1776_RS18965	COG0081	regulation of translation
L1776_RS18970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L1776_RS18990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L1776_RS19015	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L1776_RS19020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L1776_RS19020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L1776_RS19050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L1776_RS19055	COG0739	heme binding
L1776_RS19060	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L1776_RS19065	COG0316	Belongs to the HesB IscA family
L1776_RS19070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L1776_RS19075	COG1981	membrane
L1776_RS19085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L1776_RS19090	COG0537	adenosine 5'-monophosphoramidase activity
L1776_RS19095	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
L1776_RS19100	COG1765	OsmC-like protein
L1776_RS19110	COG0134	indole-3-glycerol-phosphate synthase activity
L1776_RS19115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L1776_RS19120	COG0512	Glutamine amidotransferase of anthranilate synthase
L1776_RS19130	COG0546	phosphoglycolate phosphatase activity
L1776_RS19135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L1776_RS19140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L1776_RS19150	COG1177	transmembrane transport
L1776_RS19155	COG1176	ABC-type spermidine putrescine transport system, permease component I
L1776_RS19165	COG3842	ATPase activity
L1776_RS19170	COG2197	response regulator
L1776_RS19185	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L1776_RS19190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L1776_RS19200	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
L1776_RS19205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L1776_RS19210	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L1776_RS19215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L1776_RS19220	COG2967	ApaG domain
L1776_RS19225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L1776_RS19230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L1776_RS19235	COG2766	serine protein kinase
L1776_RS19240	COG2718	Belongs to the UPF0229 family
L1776_RS19245	COG2719	SpoVR family
L1776_RS19250	COG0617	tRNA 3'-terminal CCA addition
L1776_RS19265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L1776_RS19270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L1776_RS19275	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L1776_RS19280	COG0358	DNA primase activity
L1776_RS19285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L1776_RS19300	COG0471	metal ion transport
L1776_RS19300	COG3273	potassium ion transport
L1776_RS19305	COG2873	o-acetylhomoserine
L1776_RS19310	COG3118	belongs to the thioredoxin family
L1776_RS19325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1776_RS19330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1776_RS19355	COG2986	histidine ammonia-lyase
L1776_RS19395	COG1028	Short-chain dehydrogenase reductase Sdr
L1776_RS19400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L1776_RS19415	COG0583	DNA-binding transcription factor activity
L1776_RS19420	COG2814	Major facilitator Superfamily
L1776_RS19430	COG0493	'glutamate synthase
L1776_RS19435	COG0067	glutamate synthase
L1776_RS19435	COG0069	glutamate synthase activity
L1776_RS19435	COG0070	glutamate synthase
L1776_RS19445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L1776_RS19450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L1776_RS19485	COG0281	malic enzyme
L1776_RS19495	COG0254	rRNA binding
L1776_RS19500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L1776_RS19505	COG0018	arginyl-trna synthetase
L1776_RS19520	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L1776_RS19535	COG0248	Ppx GppA phosphatase
L1776_RS19540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L1776_RS19550	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
L1776_RS19565	COG1671	Belongs to the UPF0178 family
L1776_RS19570	COG1280	lysine exporter protein (LysE YggA)
L1776_RS19575	COG0861	Integral membrane protein TerC family
L1776_RS19585	COG0488	(ABC) transporter
L1776_RS19605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L1776_RS19625	COG0181	hydroxymethylbilane synthase activity
L1776_RS19635	COG3275	phosphorelay sensor kinase activity
L1776_RS19640	COG0165	Argininosuccinate lyase
L1776_RS19675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1776_RS19680	COG1965	Belongs to the frataxin family
L1776_RS19695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L1776_RS19705	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L1776_RS19720	COG0432	Pfam Uncharacterised protein family UPF0047
L1776_RS19725	COG0004	ammonium transporteR
L1776_RS19730	COG0004	ammonium transporteR
L1776_RS19735	COG0347	Belongs to the P(II) protein family
L1776_RS19745	COG0606	chelatase, subunit chli
L1776_RS19750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L1776_RS19760	COG0210	DNA helicase
L1776_RS19765	COG1272	protein, Hemolysin III
L1776_RS19770	COG1414	Transcriptional regulator
L1776_RS19780	COG1454	alcohol dehydrogenase
L1776_RS19790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L1776_RS19795	COG0366	Alpha amylase catalytic
L1776_RS19810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L1776_RS19830	COG0251	oxidation-reduction process
L1776_RS19835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1776_RS19850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L1776_RS19870	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1776_RS19885	COG2003	Belongs to the UPF0758 family
L1776_RS19890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L1776_RS19895	COG0756	dUTP diphosphatase activity
L1776_RS19905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L1776_RS19920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L1776_RS19925	COG0708	Exodeoxyribonuclease III
L1776_RS19935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L1776_RS19940	COG1561	YicC-like family, N-terminal region
L1776_RS19950	COG1758	RNA polymerase activity
L1776_RS19955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L1776_RS19975	COG2080	2 iron, 2 sulfur cluster binding
L1776_RS19995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L1776_RS20015	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L1776_RS20020	COG1704	LemA family
L1776_RS20025	COG0583	DNA-binding transcription factor activity
L1776_RS20030	COG0604	alcohol dehydrogenase
L1776_RS20040	COG1960	acyl-CoA dehydrogenase activity
L1776_RS20045	COG0583	DNA-binding transcription factor activity
L1776_RS20070	COG1620	l-lactate permease
L1776_RS20075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L1776_RS20080	COG3193	protein, possibly involved in utilization of glycolate and propanediol
L1776_RS20085	COG0247	lactate metabolic process
L1776_RS20090	COG0277	FAD linked oxidase domain protein
L1776_RS20095	COG0277	FAD linked oxidase domain protein
L1776_RS20100	COG2186	Transcriptional regulator
L1776_RS20105	COG3161	chorismate lyase activity
L1776_RS20110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L1776_RS20125	COG1253	flavin adenine dinucleotide binding
L1776_RS20135	COG0739	heme binding
L1776_RS20155	COG0411	ABC transporter
L1776_RS20165	COG0559	Belongs to the binding-protein-dependent transport system permease family
L1776_RS20175	COG1192	Involved in chromosome partitioning
L1776_RS20180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L1776_RS20185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L1776_RS20190	COG0730	response to heat
L1776_RS20205	COG0494	nUDIX hydrolase
L1776_RS20225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L1776_RS20230	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L1776_RS20250	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1776_RS20255	COG0277	FAD linked oxidase domain protein
L1776_RS20260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1776_RS20285	COG2197	response regulator
L1776_RS20325	COG0651	ATP synthesis coupled electron transport
L1776_RS20330	COG0651	ATP synthesis coupled electron transport
L1776_RS20350	COG1320	monovalent cation:proton antiporter activity
L1776_RS20365	COG1966	Carbon starvation protein
L1776_RS20395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L1776_RS20400	COG5001	Diguanylate cyclase
L1776_RS20425	COG4807	Protein conserved in bacteria
L1776_RS20430	COG2204	response regulator
L1776_RS20455	COG4565	transcriptional regulatory protein
L1776_RS20460	COG3290	protein histidine kinase activity
L1776_RS20465	COG3493	citrate carrier protein
L1776_RS20475	COG1217	gtp-binding protein TYPA
L1776_RS20480	COG0301	tRNA thio-modification
L1776_RS20480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L1776_RS20500	COG3852	Histidine kinase
L1776_RS20520	COG0243	molybdopterin cofactor binding
L1776_RS20530	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L1776_RS20540	COG0840	transmembrane signaling receptor activity
L1776_RS20550	COG2226	methyltransferase
L1776_RS20560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L1776_RS20565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L1776_RS20570	COG0140	phosphoribosyl-ATP diphosphatase activity
L1776_RS20575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L1776_RS20580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L1776_RS20600	COG1490	D-aminoacyl-tRNA deacylase activity
L1776_RS20630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
L1776_RS20635	COG0058	SHG alpha-glucan phosphorylase activity
L1776_RS20650	COG1218	3'(2'),5'-bisphosphate nucleotidase
L1776_RS20655	COG0494	nUDIX hydrolase
L1776_RS20660	COG1011	Hydrolase
L1776_RS20665	COG4191	Histidine kinase
L1776_RS20665	COG0784	Response regulator, receiver
L1776_RS20670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L1776_RS20690	COG1960	acyl-CoA dehydrogenase activity
L1776_RS20695	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1776_RS20695	COG1024	Enoyl-CoA hydratase
L1776_RS20705	COG1366	Belongs to the anti-sigma-factor antagonist family
L1776_RS20710	COG1366	Belongs to the anti-sigma-factor antagonist family
L1776_RS20715	COG2172	sigma factor antagonist activity
L1776_RS20725	COG2205	protein histidine kinase activity
L1776_RS20730	COG0784	Response regulator, receiver
L1776_RS20730	COG4191	Histidine kinase
L1776_RS20755	COG0667	Aldo Keto reductase
L1776_RS20765	COG0747	negative chemotaxis
L1776_RS20780	COG0019	diaminopimelate decarboxylase activity
L1776_RS20795	COG0840	transmembrane signaling receptor activity
L1776_RS20800	COG0514	ATP-dependent DNA helicase (RecQ)
L1776_RS20810	COG0778	Nitroreductase
L1776_RS20820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L1776_RS20830	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L1776_RS20835	COG0189	ligase activity
L1776_RS20835	COG4067	protein conserved in archaea
L1776_RS20840	COG0189	ligase activity
L1776_RS20890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L1776_RS20895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L1776_RS20950	COG0305	Participates in initiation and elongation during chromosome replication
L1776_RS20955	COG2894	cell division
L1776_RS21000	COG4372	Transposase
L1776_RS21030	COG0131	Imidazoleglycerol-phosphate dehydratase
L1776_RS21050	COG4644	lycopene metabolic process
L1776_RS21085	COG3077	Addiction module antitoxin, RelB DinJ family
L1776_RS21120	COG1737	Transcriptional regulator
L1776_RS21120	COG0837	glucose binding
L1776_RS21135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1776_RS21140	COG1309	transcriptional regulator
L1776_RS21145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L1776_RS21205	COG4974	Belongs to the 'phage' integrase family