locus-tag	class	description
D1868_RS00045	COG3387	PFAM Glycoside hydrolase 15-related
D1868_RS00060	COG0813	purine-nucleoside phosphorylase activity
D1868_RS00140	COG1252	NADH dehydrogenase
D1868_RS00150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1868_RS00155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1868_RS00160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1868_RS00175	COG0045	succinate-CoA ligase (ADP-forming) activity
D1868_RS00205	COG1185	polyribonucleotide nucleotidyltransferase activity
D1868_RS00240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1868_RS00265	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D1868_RS00290	COG0300	oxidoreductase activity
D1868_RS00315	COG0477	Major facilitator Superfamily
D1868_RS00345	COG2848	UPF0210 protein
D1868_RS00405	COG0402	S-adenosylhomocysteine deaminase activity
D1868_RS00420	COG0730	response to heat
D1868_RS00435	COG0477	Major facilitator Superfamily
D1868_RS00465	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1868_RS00505	COG0243	molybdopterin cofactor binding
D1868_RS00510	COG0515	serine threonine protein kinase
D1868_RS00525	COG1252	NADH dehydrogenase
D1868_RS00545	COG0037	tRNA processing
D1868_RS00565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1868_RS00585	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1868_RS00640	COG0475	glutathione-regulated potassium exporter activity
D1868_RS00685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1868_RS00695	COG0495	leucyl-tRNA aminoacylation
D1868_RS00720	COG1573	uracil-dna glycosylase
D1868_RS00725	COG1028	Short-chain dehydrogenase reductase Sdr
D1868_RS00730	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1868_RS00765	COG0438	transferase activity, transferring glycosyl groups
D1868_RS00770	COG2814	Major facilitator Superfamily
D1868_RS00775	COG1846	Transcriptional regulator
D1868_RS00785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1868_RS00790	COG0649	NAD binding
D1868_RS00795	COG0651	ATP synthesis coupled electron transport
D1868_RS00805	COG0650	Formate hydrogenlyase subunit 4
D1868_RS00820	COG2814	Major facilitator Superfamily
D1868_RS00825	COG0513	Belongs to the DEAD box helicase family
D1868_RS00835	COG3276	selenocysteine insertion sequence binding
D1868_RS00850	COG1131	(ABC) transporter
D1868_RS00855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1868_RS00855	COG1648	precorrin-2 dehydrogenase activity
D1868_RS00860	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1868_RS00865	COG0113	porphobilinogen synthase activity
D1868_RS00870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1868_RS00875	COG0181	hydroxymethylbilane synthase activity
D1868_RS00910	COG1793	dna ligase
D1868_RS00915	COG0717	Belongs to the dCTP deaminase family
D1868_RS00960	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
D1868_RS00975	COG0504	CTP synthase activity
D1868_RS01000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1868_RS01030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1868_RS01035	COG0456	acetyltransferase
D1868_RS01080	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1868_RS01090	COG1047	Peptidyl-prolyl cis-trans
D1868_RS01095	COG0371	Dehydrogenase
D1868_RS01100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1868_RS01135	COG0778	Nitroreductase
D1868_RS01140	COG0066	3-isopropylmalate dehydratase activity
D1868_RS01145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1868_RS01150	COG0805	protein transport
D1868_RS01165	COG1116	anion transmembrane transporter activity
D1868_RS01175	COG0439	Biotin carboxylase
D1868_RS01185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1868_RS01200	COG0306	phosphate transporter
D1868_RS01210	COG0372	Belongs to the citrate synthase family
D1868_RS01225	COG0450	alkyl hydroperoxide reductase
D1868_RS01240	COG1515	deoxyribonuclease V activity
D1868_RS01250	COG0277	FAD linked oxidase domain protein
D1868_RS01255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1868_RS01270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1868_RS01275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1868_RS01280	COG1051	belongs to the nudix hydrolase family
D1868_RS01285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1868_RS01290	COG0519	Catalyzes the synthesis of GMP from XMP
D1868_RS01290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1868_RS01295	COG0157	Belongs to the NadC ModD family
D1868_RS01310	COG0535	radical SAM domain protein
D1868_RS01315	COG0535	radical SAM domain protein
D1868_RS01325	COG0028	Belongs to the TPP enzyme family
D1868_RS01350	COG0017	Asparaginyl-tRNA synthetase
D1868_RS01375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1868_RS01385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1868_RS01385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1868_RS01425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1868_RS01480	COG0315	cyclic pyranopterin monophosphate synthase activity
D1868_RS01485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1868_RS01490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1868_RS01495	COG1881	PFAM PEBP family protein
D1868_RS01500	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1868_RS01505	COG0154	amidase activity
D1868_RS01530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1868_RS01550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1868_RS01555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1868_RS01560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1868_RS01565	COG0189	ligase activity
D1868_RS01575	COG1522	sequence-specific DNA binding
D1868_RS01580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1868_RS01585	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1868_RS01600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1868_RS01640	COG0051	transcription antitermination factor activity, RNA binding
D1868_RS01645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1868_RS01650	COG0049	tRNA binding
D1868_RS01665	COG0195	Participates in both transcription termination and antitermination
D1868_RS01670	COG1358	cellular component organization or biogenesis
D1868_RS01675	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1868_RS01680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1868_RS01685	COG0085	RNA polymerase activity
D1868_RS01695	COG0281	malic enzyme
D1868_RS01700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1868_RS01705	COG0105	UTP biosynthetic process
D1868_RS01720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1868_RS01725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1868_RS01730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1868_RS01740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1868_RS01745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1868_RS01760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1868_RS01775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1868_RS01780	COG0644	oxidoreductase
D1868_RS01780	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
D1868_RS01785	COG1522	sequence-specific DNA binding
D1868_RS01790	COG1605	Chorismate mutase
D1868_RS01790	COG0077	Prephenate dehydratase
D1868_RS01795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1868_RS01815	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D1868_RS01815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1868_RS01830	COG1051	belongs to the nudix hydrolase family
D1868_RS01830	COG1056	cytidyltransferase-related domain
D1868_RS01870	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D1868_RS01905	COG1121	(ABC) transporter
D1868_RS01910	COG1980	fructose-bisphosphate aldolase activity
D1868_RS01935	COG0459	protein refolding
D1868_RS01950	COG0124	histidyl-tRNA synthetase
D1868_RS01985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1868_RS01995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1868_RS02040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1868_RS02075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1868_RS02080	COG2264	protein methyltransferase activity
D1868_RS02085	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1868_RS02095	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D1868_RS02140	COG1185	polyribonucleotide nucleotidyltransferase activity
D1868_RS02145	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1868_RS02165	COG0322	excinuclease ABC activity
D1868_RS02170	COG0492	ferredoxin-NADP+ reductase activity
D1868_RS02175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1868_RS02180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1868_RS02195	COG0473	3-isopropylmalate dehydrogenase activity
D1868_RS02200	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1868_RS02220	COG0089	rRNA binding
D1868_RS02225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1868_RS02230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1868_RS02235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1868_RS02245	COG0255	Belongs to the universal ribosomal protein uL29 family
D1868_RS02255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1868_RS02260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1868_RS02265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1868_RS02275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1868_RS02285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1868_RS02290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1868_RS02310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1868_RS02320	COG0200	Binds to the 23S rRNA
D1868_RS02345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1868_RS02370	COG0438	transferase activity, transferring glycosyl groups
D1868_RS02395	COG2813	Specifically methylates the guanine in position
D1868_RS02400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1868_RS02405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1868_RS02415	COG1201	RNA secondary structure unwinding
D1868_RS02420	COG0433	COG0433 Predicted ATPase
D1868_RS02445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1868_RS02465	COG1797	cobyrinic acid a,c-diamide synthase activity
D1868_RS02480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1868_RS02525	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
D1868_RS02530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1868_RS02535	COG1110	DNA topoisomerase II activity
D1868_RS02580	COG0667	Aldo Keto reductase
D1868_RS02585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1868_RS02610	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
D1868_RS02620	COG0163	prenyltransferase activity
D1868_RS02650	COG0423	glycine-tRNA ligase activity
D1868_RS02655	COG0010	Belongs to the arginase family
D1868_RS02715	COG0023	Translation Initiation Factor
D1868_RS02785	COG0489	protein tyrosine kinase activity
D1868_RS02800	COG1994	Peptidase M50
D1868_RS02825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1868_RS02830	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D1868_RS02835	COG4974	Belongs to the 'phage' integrase family
D1868_RS02850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1868_RS02850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1868_RS02860	COG0318	PFAM AMP-dependent synthetase and ligase
D1868_RS02875	COG0174	glutamine synthetase
D1868_RS02895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1868_RS02910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1868_RS02925	COG2848	UPF0210 protein
D1868_RS02990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1868_RS02995	COG0081	regulation of translation
D1868_RS03000	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1868_RS03010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1868_RS03085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1868_RS03175	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1868_RS03180	COG1122	ATPase activity
D1868_RS03195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1868_RS03200	COG0297	glycogen (starch) synthase activity
D1868_RS03210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1868_RS03225	COG0516	GMP reductase activity
D1868_RS03225	COG0517	IMP dehydrogenase activity
D1868_RS03250	COG2815	serine threonine protein kinase
D1868_RS03250	COG0515	serine threonine protein kinase
D1868_RS03260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1868_RS03265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1868_RS03285	COG2271	Major facilitator Superfamily
D1868_RS03300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1868_RS03345	COG0501	Belongs to the peptidase M48B family
D1868_RS03355	COG4139	cobalamin transport
D1868_RS03360	COG1121	(ABC) transporter
D1868_RS03405	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1868_RS03405	COG0517	IMP dehydrogenase activity
D1868_RS03410	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D1868_RS03415	COG2079	MmgE PrpD family protein
D1868_RS03420	COG0039	L-malate dehydrogenase activity
D1868_RS03430	COG1131	(ABC) transporter
D1868_RS03460	COG1136	(ABC) transporter
D1868_RS03470	COG0577	efflux transmembrane transporter activity
D1868_RS03475	COG0577	efflux transmembrane transporter activity
D1868_RS03475	COG1136	(ABC) transporter
D1868_RS03515	COG3386	PFAM SMP-30 Gluconolaconase
D1868_RS03535	COG1720	tRNA m6t6A37 methyltransferase activity
D1868_RS03575	COG2242	protein methyltransferase activity
D1868_RS03595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1868_RS03595	COG1648	precorrin-2 dehydrogenase activity
D1868_RS03620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1868_RS03650	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D1868_RS03655	COG0517	IMP dehydrogenase activity
D1868_RS03685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1868_RS03725	COG2017	converts alpha-aldose to the beta-anomer
D1868_RS03785	COG3511	phospholipase C
D1868_RS03835	COG2226	methyltransferase
D1868_RS03850	COG0515	serine threonine protein kinase
D1868_RS03860	COG4608	Belongs to the ABC transporter superfamily
D1868_RS03870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1868_RS03875	COG0601	transmembrane transport
D1868_RS03955	COG0004	ammonium transporteR
D1868_RS03965	COG0450	alkyl hydroperoxide reductase
D1868_RS03985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1868_RS03990	COG2860	membrane
D1868_RS04000	COG0477	Major facilitator Superfamily
D1868_RS04025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1868_RS04030	COG0515	serine threonine protein kinase
D1868_RS04030	COG3266	domain, Protein
D1868_RS04035	COG2723	6-phospho-beta-galactosidase activity
D1868_RS04050	COG0515	serine threonine protein kinase
D1868_RS04055	COG0415	Belongs to the DNA photolyase family
D1868_RS04095	COG1733	regulation of RNA biosynthetic process
D1868_RS04105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1868_RS04170	COG0154	amidase activity
D1868_RS04175	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1868_RS04180	COG1324	tolerance protein
D1868_RS04215	COG1110	DNA topoisomerase II activity
D1868_RS04225	COG1201	RNA secondary structure unwinding
D1868_RS04255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1868_RS04260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1868_RS04270	COG1028	Short-chain dehydrogenase reductase Sdr
D1868_RS04280	COG0528	UMP kinase activity
D1868_RS04300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D1868_RS04300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1868_RS04350	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
D1868_RS04380	COG0252	asparaginase activity
D1868_RS04385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1868_RS04400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1868_RS04405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1868_RS04410	COG1584	GPR1 FUN34 yaaH family protein
D1868_RS04450	COG0459	protein refolding
D1868_RS04485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1868_RS04495	COG0587	DNA-directed DNA polymerase activity
D1868_RS04505	COG0527	aspartate kinase activity
D1868_RS04505	COG0460	homoserine dehydrogenase
D1868_RS04530	COG0574	Belongs to the PEP-utilizing enzyme family
D1868_RS04530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1868_RS04540	COG1254	Belongs to the acylphosphatase family
D1868_RS04545	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
D1868_RS04550	COG0159	tryptophan synthase activity
D1868_RS04555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1868_RS04560	COG0135	phosphoribosylanthranilate isomerase activity
D1868_RS04565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1868_RS04570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1868_RS04570	COG0512	Glutamine amidotransferase of anthranilate synthase
D1868_RS04580	COG0436	Aminotransferase
D1868_RS04585	COG0525	valine-tRNA ligase activity
D1868_RS04615	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
D1868_RS04620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1868_RS04635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1868_RS04710	COG0719	Fe-S assembly protein
D1868_RS04715	COG0719	Fe-S assembly protein
D1868_RS04720	COG0396	ATPase activity
D1868_RS04740	COG0509	glycine decarboxylation via glycine cleavage system
D1868_RS04745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1868_RS04750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1868_RS04755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1868_RS04770	COG0148	phosphopyruvate hydratase activity
D1868_RS04790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1868_RS04795	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1868_RS04825	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D1868_RS04850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1868_RS04890	COG4962	Type ii secretion system protein e
D1868_RS04925	COG1201	RNA secondary structure unwinding
D1868_RS04930	COG0617	tRNA 3'-terminal CCA addition
D1868_RS04930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1868_RS04930	COG0517	IMP dehydrogenase activity
D1868_RS04955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1868_RS04960	COG1058	Belongs to the CinA family
D1868_RS04960	COG1546	Belongs to the CinA family
D1868_RS04965	COG2267	carboxylic ester hydrolase activity
D1868_RS04970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1868_RS04970	COG0072	phenylalanine-tRNA ligase activity
D1868_RS04980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1868_RS05005	COG1078	dGTPase activity
D1868_RS05010	COG0561	phosphatase activity
D1868_RS05015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1868_RS05035	COG0417	DNA replication proofreading
D1868_RS05045	COG2264	protein methyltransferase activity
D1868_RS05065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1868_RS05085	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
D1868_RS05110	COG0442	prolyl-tRNA aminoacylation
D1868_RS05120	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D1868_RS05125	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D1868_RS05140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1868_RS05150	COG0028	Belongs to the TPP enzyme family
D1868_RS05160	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D1868_RS05170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1868_RS05185	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D1868_RS05195	COG0037	tRNA processing
D1868_RS05200	COG2096	Adenosyltransferase
D1868_RS05205	COG0495	leucyl-tRNA aminoacylation
D1868_RS05215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1868_RS05220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1868_RS05225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1868_RS05230	COG0131	Imidazoleglycerol-phosphate dehydratase
D1868_RS05235	COG0107	imidazoleglycerol-phosphate synthase activity
D1868_RS05240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1868_RS05245	COG0140	phosphoribosyl-ATP diphosphatase activity
D1868_RS05250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1868_RS05260	COG2151	metal-sulfur cluster biosynthetic enzyme
D1868_RS05265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1868_RS05270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1868_RS05280	COG0537	adenosine 5'-monophosphoramidase activity
D1868_RS05290	COG1522	sequence-specific DNA binding
D1868_RS05310	COG0167	dihydroorotate dehydrogenase activity
D1868_RS05315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1868_RS05325	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
D1868_RS05330	COG0540	Belongs to the ATCase OTCase family
D1868_RS05335	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1868_RS05360	COG0640	Transcriptional regulator
D1868_RS05380	COG0602	queuosine metabolic process
D1868_RS05385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1868_RS05390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1868_RS05390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1868_RS05395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1868_RS05405	COG0047	phosphoribosylformylglycinamidine synthase activity
D1868_RS05410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1868_RS05415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1868_RS05420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1868_RS05425	COG0151	Belongs to the GarS family
D1868_RS05430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1868_RS05445	COG0137	argininosuccinate synthase activity
D1868_RS05450	COG0165	Argininosuccinate lyase
D1868_RS05455	COG0505	Belongs to the CarA family
D1868_RS05465	COG0189	ligase activity
D1868_RS05475	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1868_RS05515	COG1024	Enoyl-CoA hydratase
D1868_RS05525	COG0109	protoheme IX farnesyltransferase activity
D1868_RS05530	COG0460	homoserine dehydrogenase
D1868_RS05540	COG0864	Transcriptional regulator
D1868_RS05545	COG0312	modulator of DNA gyrase
D1868_RS05560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D1868_RS05560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D1868_RS05565	COG0009	L-threonylcarbamoyladenylate synthase
D1868_RS05570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1868_RS05595	COG0045	succinate-CoA ligase (ADP-forming) activity
D1868_RS05595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1868_RS05595	COG1042	CoA-binding domain protein
D1868_RS05600	COG0469	pyruvate kinase activity
D1868_RS05620	COG2226	methyltransferase
D1868_RS05635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1868_RS05665	COG0601	transmembrane transport
D1868_RS05675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1868_RS05710	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D1868_RS05720	COG2226	methyltransferase
D1868_RS05725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1868_RS05750	COG1139	Iron-sulfur cluster binding protein
D1868_RS05840	COG2329	Antibiotic biosynthesis monooxygenase
D1868_RS05870	COG0402	S-adenosylhomocysteine deaminase activity
D1868_RS05875	COG0174	glutamine synthetase
D1868_RS05925	COG0402	S-adenosylhomocysteine deaminase activity
D1868_RS05930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1868_RS05945	COG0402	S-adenosylhomocysteine deaminase activity
D1868_RS05950	COG1522	sequence-specific DNA binding
D1868_RS05965	COG2308	Evidence 4 Homologs of previously reported genes of
D1868_RS05985	COG0804	urea catabolic process
D1868_RS05990	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D1868_RS05995	COG0830	nickel cation binding
D1868_RS06000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1868_RS06010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1868_RS06010	COG0519	Catalyzes the synthesis of GMP from XMP
D1868_RS06015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1868_RS06020	COG1953	Uracil, thiamine, allantoin
D1868_RS06030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1868_RS06045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1868_RS06110	COG0601	transmembrane transport
D1868_RS06115	COG0444	Belongs to the ABC transporter superfamily
D1868_RS06120	COG4608	Belongs to the ABC transporter superfamily
D1868_RS06135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1868_RS06155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1868_RS06170	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D1868_RS06175	COG1473	amidohydrolase
D1868_RS06180	COG0477	Major facilitator Superfamily
D1868_RS06190	COG0531	amino acid
D1868_RS06205	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D1868_RS06225	COG0243	molybdopterin cofactor binding
D1868_RS06235	COG2235	arginine
D1868_RS06265	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1868_RS06270	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1868_RS06275	COG1144	Oxidoreductase
D1868_RS06280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D1868_RS06285	COG0437	4 iron, 4 sulfur cluster binding
D1868_RS06300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1868_RS06405	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D1868_RS06410	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D1868_RS06430	COG0298	carbon dioxide binding
D1868_RS06455	COG1335	isochorismatase
D1868_RS06465	COG0298	carbon dioxide binding
D1868_RS06485	COG1144	Oxidoreductase
D1868_RS06490	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1868_RS06495	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1868_RS06535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1868_RS06540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1868_RS06590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1868_RS06615	COG0598	Magnesium transport protein CorA
D1868_RS06750	COG0668	transmembrane transport
D1868_RS06760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1868_RS06795	COG1063	alcohol dehydrogenase
D1868_RS06800	COG2301	Belongs to the HpcH HpaI aldolase family
D1868_RS06805	COG2271	Major facilitator Superfamily
D1868_RS06935	COG0438	transferase activity, transferring glycosyl groups
D1868_RS06940	COG0463	Glycosyl transferase, family 2
D1868_RS06950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1868_RS06965	COG0477	Major facilitator Superfamily
D1868_RS06985	COG1131	(ABC) transporter
D1868_RS07015	COG0477	Major facilitator Superfamily
D1868_RS07025	COG2814	Major facilitator Superfamily
D1868_RS07035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1868_RS07085	COG2814	Major facilitator Superfamily
D1868_RS07090	COG1846	Transcriptional regulator
D1868_RS07100	COG0375	protein maturation
D1868_RS07130	COG0309	Hydrogenase expression formation protein (HypE)
D1868_RS07140	COG0409	Hydrogenase expression formation protein
D1868_RS07180	COG1575	Belongs to the MenA family. Type 1 subfamily
D1868_RS07285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1868_RS07340	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D1868_RS07345	COG0243	molybdopterin cofactor binding
D1868_RS07435	COG3383	formate dehydrogenase (NAD+) activity
D1868_RS07470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1868_RS07490	COG1091	dTDP-4-dehydrorhamnose reductase activity
D1868_RS07525	COG1489	DNA binding
D1868_RS07555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1868_RS07560	COG1960	acyl-CoA dehydrogenase activity
D1868_RS07585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1868_RS07615	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D1868_RS07620	COG1953	Uracil, thiamine, allantoin
D1868_RS07640	COG1573	uracil-dna glycosylase
D1868_RS07645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D1868_RS07735	COG1968	undecaprenyl-diphosphatase activity
D1868_RS07775	COG2271	Major facilitator Superfamily
D1868_RS07805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1868_RS07815	COG1131	(ABC) transporter
D1868_RS07845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1868_RS07915	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D1868_RS07920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1868_RS07920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1868_RS07925	COG0346	lactoylglutathione lyase activity
D1868_RS07930	COG0071	Belongs to the small heat shock protein (HSP20) family
D1868_RS07940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1868_RS07955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1868_RS07970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1868_RS07975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1868_RS07985	COG0430	RNA-3'-phosphate cyclase activity
D1868_RS07995	COG0174	glutamine synthetase
D1868_RS08010	COG0402	S-adenosylhomocysteine deaminase activity
D1868_RS08055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1868_RS08060	COG0215	cysteine-tRNA ligase activity
D1868_RS08065	COG2222	sugar isomerase
D1868_RS08075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1868_RS08085	COG0433	COG0433 Predicted ATPase
D1868_RS08105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D1868_RS08110	COG1960	acyl-CoA dehydrogenase activity
D1868_RS08145	COG1185	polyribonucleotide nucleotidyltransferase activity
D1868_RS08180	COG3959	Transketolase, thiamine diphosphate binding domain
D1868_RS08185	COG3958	Transketolase
D1868_RS08195	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D1868_RS08200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1868_RS08205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1868_RS08210	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1868_RS08215	COG0083	homoserine kinase activity
D1868_RS08220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1868_RS08265	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1868_RS08275	COG1331	Highly conserved protein containing a thioredoxin domain
D1868_RS08290	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D1868_RS08310	COG1192	Involved in chromosome partitioning
D1868_RS08315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1868_RS08320	COG0277	FAD linked oxidase domain protein
D1868_RS08335	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1868_RS08365	COG0517	IMP dehydrogenase activity
D1868_RS08375	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D1868_RS08440	COG1215	transferase activity, transferring glycosyl groups
D1868_RS08450	COG0351	phosphomethylpyrimidine kinase
D1868_RS08455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1868_RS08475	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1868_RS08480	COG0006	proline dipeptidase activity
D1868_RS08500	COG0463	Glycosyl transferase, family 2
D1868_RS08530	COG1201	RNA secondary structure unwinding
D1868_RS08540	COG1063	alcohol dehydrogenase
D1868_RS08560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1868_RS08560	COG0519	Catalyzes the synthesis of GMP from XMP
D1868_RS08565	COG0501	Belongs to the peptidase M48B family
D1868_RS08580	COG1444	tRNA N-acetyltransferase activity
D1868_RS08595	COG0405	Gamma-glutamyltransferase
D1868_RS08605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1868_RS08620	COG1830	Aldolase
D1868_RS08660	COG2814	Major facilitator Superfamily
D1868_RS08665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1868_RS08670	COG0589	response to stress
D1868_RS08685	COG1592	Rubrerythrin
D1868_RS08690	COG0516	GMP reductase activity
D1868_RS08690	COG0517	IMP dehydrogenase activity
D1868_RS08705	COG0730	response to heat
D1868_RS08750	COG0586	Pfam SNARE associated Golgi protein
D1868_RS08800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1868_RS08800	COG0301	tRNA thio-modification
D1868_RS08805	COG1260	myo-inositol-1-phosphate synthase
D1868_RS08810	COG1007	ATP synthesis coupled electron transport
D1868_RS08815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1868_RS08830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1868_RS08835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1868_RS08840	COG0649	NAD binding
D1868_RS08845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1868_RS08890	COG0330	HflC and HflK could
D1868_RS08915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1868_RS08920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1868_RS08940	COG0067	glutamate synthase
D1868_RS08945	COG0069	glutamate synthase activity
D1868_RS09000	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1868_RS09005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1868_RS09010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1868_RS09030	COG2096	Adenosyltransferase
D1868_RS09055	COG0500	methyltransferase
D1868_RS09055	COG3615	Tellurite resistance protein tehB
D1868_RS09075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1868_RS09095	COG0538	isocitrate dehydrogenase activity
D1868_RS09115	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1868_RS09140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1868_RS09140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1868_RS09145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1868_RS09155	COG1618	nucleotide phosphatase activity, acting on free nucleotides
D1868_RS09165	COG0494	nUDIX hydrolase
D1868_RS09185	COG0561	phosphatase activity
D1868_RS09195	COG1011	Hydrolase
D1868_RS09205	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1868_RS09215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1868_RS09225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1868_RS09240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1868_RS09250	COG0492	ferredoxin-NADP+ reductase activity
D1868_RS09315	COG3118	belongs to the thioredoxin family
D1868_RS09335	COG0516	GMP reductase activity
D1868_RS09335	COG0517	IMP dehydrogenase activity
D1868_RS09380	COG0419	ATPase involved in DNA repair
D1868_RS09380	COG0419	ATPase involved in DNA repair
D1868_RS09405	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D1868_RS09405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1868_RS09410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1868_RS09415	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1868_RS09455	COG0456	acetyltransferase
D1868_RS09460	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1868_RS09465	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D1868_RS09490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1868_RS09525	COG0417	DNA replication proofreading
D1868_RS09535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1868_RS09545	COG0432	Pfam Uncharacterised protein family UPF0047
D1868_RS09555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1868_RS09560	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1868_RS09565	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1868_RS09575	COG0200	Binds to the 23S rRNA
D1868_RS09580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1868_RS09585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1868_RS09595	COG0052	Belongs to the universal ribosomal protein uS2 family
D1868_RS09600	COG1355	regulation of microtubule-based process
D1868_RS09610	COG1304	FMN binding
D1868_RS09620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1868_RS09630	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1868_RS09675	COG0402	S-adenosylhomocysteine deaminase activity
D1868_RS09690	COG0746	molybdenum cofactor guanylyltransferase activity
D1868_RS09695	COG0303	'Molybdopterin
D1868_RS09700	COG1763	Mo-molybdopterin cofactor biosynthetic process
D1868_RS09730	COG1321	iron dependent repressor
D1868_RS09745	COG0725	ABC transporter, periplasmic molybdate-binding protein
D1868_RS09750	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D1868_RS09760	COG2022	thiamine diphosphate biosynthetic process
D1868_RS09785	COG0494	nUDIX hydrolase
D1868_RS09790	COG0114	fumarate hydratase activity
D1868_RS09795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1868_RS09825	COG1444	tRNA N-acetyltransferase activity
D1868_RS09835	COG0708	Exodeoxyribonuclease III
D1868_RS09840	COG0515	serine threonine protein kinase
D1868_RS09840	COG2815	serine threonine protein kinase
D1868_RS09850	COG1914	H( )-stimulated, divalent metal cation uptake system
D1868_RS09880	COG0095	Lipoate-protein ligase
D1868_RS09885	COG0509	glycine decarboxylation via glycine cleavage system
D1868_RS09890	COG0509	glycine decarboxylation via glycine cleavage system
D1868_RS09900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D1868_RS09920	COG0095	Lipoate-protein ligase
D1868_RS09930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1868_RS09970	COG2210	Belongs to the sulfur carrier protein TusA family
D1868_RS09975	COG2210	Belongs to the sulfur carrier protein TusA family
D1868_RS09980	COG0425	Belongs to the sulfur carrier protein TusA family
D1868_RS09995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1868_RS10010	COG2048	Heterodisulfide reductase, subunit B
D1868_RS10045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1868_RS10050	COG0656	L-ascorbic acid biosynthetic process
D1868_RS10055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1868_RS10075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1868_RS10085	COG1132	(ABC) transporter
D1868_RS10100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1868_RS10165	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1868_RS10170	COG0456	acetyltransferase
D1868_RS10195	COG1832	CoA-binding protein
D1868_RS10210	COG0351	phosphomethylpyrimidine kinase
D1868_RS10220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1868_RS10245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1868_RS10265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1868_RS10270	COG0183	Belongs to the thiolase family
D1868_RS10310	COG0626	cystathionine gamma-synthase activity
D1868_RS10315	COG0083	homoserine kinase activity
D1868_RS10320	COG0303	'Molybdopterin
D1868_RS10335	COG0714	Associated with various cellular activities
D1868_RS10340	COG2304	oxidoreductase activity
D1868_RS10350	COG2048	Heterodisulfide reductase, subunit B
D1868_RS10380	COG0644	oxidoreductase
D1868_RS10410	COG1522	sequence-specific DNA binding
D1868_RS10415	COG0189	ligase activity
D1868_RS10430	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1868_RS10455	COG0709	Synthesizes selenophosphate from selenide and ATP
D1868_RS10460	COG1131	(ABC) transporter
D1868_RS10475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1868_RS10475	COG1845	cytochrome c oxidase, subunit III
D1868_RS10495	COG3842	ATPase activity
D1868_RS10575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1868_RS10580	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D1868_RS10685	COG0475	glutathione-regulated potassium exporter activity
D1868_RS10685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1868_RS10700	COG0531	amino acid
D1868_RS10705	COG0601	transmembrane transport
D1868_RS10710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1868_RS10715	COG0444	Belongs to the ABC transporter superfamily
D1868_RS10720	COG4608	Belongs to the ABC transporter superfamily
D1868_RS10760	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D1868_RS10765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1868_RS10795	COG0823	Involved in the tonB-independent uptake of proteins
D1868_RS10795	COG1506	peptidase
D1868_RS10795	COG4946	Tricorn protease homolog
D1868_RS10800	COG1012	belongs to the aldehyde dehydrogenase family
D1868_RS10815	COG0693	protein deglycase activity
D1868_RS10820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1868_RS10825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1868_RS10835	COG1012	belongs to the aldehyde dehydrogenase family
D1868_RS10840	COG0531	amino acid
D1868_RS10850	COG2431	L-lysine efflux transmembrane transporter activity