locus-tag	class	description
KN1_RS00010	COG0515	serine threonine protein kinase
KN1_RS00010	COG2815	serine threonine protein kinase
KN1_RS00015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KN1_RS00020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KN1_RS00040	COG1373	ATPase (AAA superfamily
KN1_RS00200	COG0438	transferase activity, transferring glycosyl groups
KN1_RS00225	COG4133	protoheme IX ABC transporter activity
KN1_RS00285	COG2192	nodulation
KN1_RS00305	COG0438	transferase activity, transferring glycosyl groups
KN1_RS00330	COG2264	protein methyltransferase activity
KN1_RS00575	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KN1_RS00585	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
KN1_RS00605	COG0298	carbon dioxide binding
KN1_RS00640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KN1_RS00720	COG1131	(ABC) transporter
KN1_RS00775	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KN1_RS00790	COG2814	Major facilitator Superfamily
KN1_RS00885	COG1131	(ABC) transporter
KN1_RS00910	COG0577	efflux transmembrane transporter activity
KN1_RS00910	COG1136	(ABC) transporter
KN1_RS00915	COG1136	(ABC) transporter
KN1_RS00950	COG1122	ATPase activity
KN1_RS00975	COG1335	isochorismatase
KN1_RS01010	COG0298	carbon dioxide binding
KN1_RS01015	COG1013	pyruvate-flavodoxin oxidoreductase activity
KN1_RS01020	COG0674	pyruvate-flavodoxin oxidoreductase activity
KN1_RS01025	COG1144	Oxidoreductase
KN1_RS01045	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KN1_RS01105	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KN1_RS01165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KN1_RS01205	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KN1_RS01265	COG3842	ATPase activity
KN1_RS01295	COG1845	cytochrome c oxidase, subunit III
KN1_RS01295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KN1_RS01300	COG1024	Enoyl-CoA hydratase
KN1_RS01340	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KN1_RS01345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KN1_RS01360	COG0189	ligase activity
KN1_RS01365	COG1522	sequence-specific DNA binding
KN1_RS01425	COG2048	Heterodisulfide reductase, subunit B
KN1_RS01435	COG2304	oxidoreductase activity
KN1_RS01440	COG0714	Associated with various cellular activities
KN1_RS01455	COG0303	'Molybdopterin
KN1_RS01460	COG0083	homoserine kinase activity
KN1_RS01465	COG0626	cystathionine gamma-synthase activity
KN1_RS01505	COG0183	Belongs to the thiolase family
KN1_RS01510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KN1_RS01530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KN1_RS01555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KN1_RS01565	COG0351	phosphomethylpyrimidine kinase
KN1_RS01580	COG1832	CoA-binding protein
KN1_RS01605	COG0456	acetyltransferase
KN1_RS01610	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KN1_RS01650	COG1215	transferase activity, transferring glycosyl groups
KN1_RS01705	COG0438	transferase activity, transferring glycosyl groups
KN1_RS01720	COG0438	transferase activity, transferring glycosyl groups
KN1_RS01735	COG0463	Glycosyl transferase, family 2
KN1_RS01745	COG1216	Glycosyl transferase, family 2
KN1_RS01755	COG0463	Glycosyl transferase, family 2
KN1_RS01760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KN1_RS01765	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KN1_RS01770	COG1088	dTDP-glucose 4,6-dehydratase activity
KN1_RS01780	COG1215	transferase activity, transferring glycosyl groups
KN1_RS01795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KN1_RS01815	COG0425	Belongs to the sulfur carrier protein TusA family
KN1_RS01845	COG0425	Belongs to the sulfur carrier protein TusA family
KN1_RS01850	COG0425	Belongs to the sulfur carrier protein TusA family
KN1_RS01875	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KN1_RS01890	COG1132	(ABC) transporter
KN1_RS01900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KN1_RS01920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KN1_RS01925	COG0656	L-ascorbic acid biosynthetic process
KN1_RS01930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KN1_RS01960	COG2048	Heterodisulfide reductase, subunit B
KN1_RS01975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KN1_RS01990	COG0425	Belongs to the sulfur carrier protein TusA family
KN1_RS01995	COG2210	Belongs to the sulfur carrier protein TusA family
KN1_RS02000	COG2210	Belongs to the sulfur carrier protein TusA family
KN1_RS02075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KN1_RS02085	COG0509	glycine decarboxylation via glycine cleavage system
KN1_RS02090	COG0509	glycine decarboxylation via glycine cleavage system
KN1_RS02095	COG0095	Lipoate-protein ligase
KN1_RS02125	COG1914	H( )-stimulated, divalent metal cation uptake system
KN1_RS02130	COG2814	Major facilitator Superfamily
KN1_RS02140	COG0708	Exodeoxyribonuclease III
KN1_RS02150	COG1444	tRNA N-acetyltransferase activity
KN1_RS02160	COG2409	Drug exporters of the RND superfamily
KN1_RS02180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KN1_RS02185	COG0114	fumarate hydratase activity
KN1_RS02215	COG0167	dihydroorotate dehydrogenase activity
KN1_RS02225	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KN1_RS02230	COG0725	ABC transporter, periplasmic molybdate-binding protein
KN1_RS02235	COG2379	hydroxypyruvate reductase
KN1_RS02245	COG1321	iron dependent repressor
KN1_RS02275	COG1763	Mo-molybdopterin cofactor biosynthetic process
KN1_RS02280	COG0303	'Molybdopterin
KN1_RS02285	COG0746	molybdenum cofactor guanylyltransferase activity
KN1_RS02300	COG0402	S-adenosylhomocysteine deaminase activity
KN1_RS02345	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KN1_RS02355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KN1_RS02360	COG0142	geranyltranstransferase activity
KN1_RS02365	COG1304	FMN binding
KN1_RS02375	COG1355	regulation of microtubule-based process
KN1_RS02380	COG0052	Belongs to the universal ribosomal protein uS2 family
KN1_RS02390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KN1_RS02395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KN1_RS02400	COG0200	Binds to the 23S rRNA
KN1_RS02410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KN1_RS02415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KN1_RS02420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KN1_RS02440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KN1_RS02450	COG0417	DNA replication proofreading
KN1_RS02485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KN1_RS02510	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KN1_RS02515	COG1250	3-hydroxyacyl-CoA dehydrogenase
KN1_RS02520	COG0456	acetyltransferase
KN1_RS02560	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
KN1_RS02565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KN1_RS02575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KN1_RS02575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KN1_RS02600	COG0419	ATPase involved in DNA repair
KN1_RS02600	COG0419	ATPase involved in DNA repair
KN1_RS02615	COG0517	IMP dehydrogenase activity
KN1_RS02615	COG0617	tRNA 3'-terminal CCA addition
KN1_RS02615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KN1_RS02645	COG0517	IMP dehydrogenase activity
KN1_RS02645	COG0516	GMP reductase activity
KN1_RS02650	COG0406	alpha-ribazole phosphatase activity
KN1_RS02675	COG1252	NADH dehydrogenase
KN1_RS02735	COG0492	ferredoxin-NADP+ reductase activity
KN1_RS02745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KN1_RS02760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KN1_RS02770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KN1_RS02780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KN1_RS02800	COG0561	phosphatase activity
KN1_RS02840	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KN1_RS02845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KN1_RS02845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KN1_RS02870	COG2154	pterin-4-alpha-carbinolamine dehydratase
KN1_RS02890	COG0538	isocitrate dehydrogenase activity
KN1_RS02910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KN1_RS02955	COG2096	Adenosyltransferase
KN1_RS02975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KN1_RS02980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KN1_RS02985	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KN1_RS03035	COG0069	glutamate synthase activity
KN1_RS03040	COG0067	glutamate synthase
KN1_RS03060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KN1_RS03100	COG1695	Transcriptional regulator
KN1_RS03125	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KN1_RS03135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KN1_RS03140	COG0649	NAD binding
KN1_RS03145	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KN1_RS03150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KN1_RS03160	COG0713	ATP synthesis coupled electron transport
KN1_RS03170	COG1007	ATP synthesis coupled electron transport
KN1_RS03175	COG1260	myo-inositol-1-phosphate synthase
KN1_RS03180	COG0301	tRNA thio-modification
KN1_RS03245	COG0586	Pfam SNARE associated Golgi protein
KN1_RS03285	COG0730	response to heat
KN1_RS03300	COG0517	IMP dehydrogenase activity
KN1_RS03300	COG0516	GMP reductase activity
KN1_RS03305	COG1592	Rubrerythrin
KN1_RS03320	COG0589	response to stress
KN1_RS03330	COG2814	Major facilitator Superfamily
KN1_RS03345	COG4948	Mandelate Racemase Muconate Lactonizing
KN1_RS03370	COG1830	Aldolase
KN1_RS03385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KN1_RS03395	COG0405	Gamma-glutamyltransferase
KN1_RS03410	COG1444	tRNA N-acetyltransferase activity
KN1_RS03425	COG0501	Belongs to the peptidase M48B family
KN1_RS03430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KN1_RS03430	COG0519	Catalyzes the synthesis of GMP from XMP
KN1_RS03445	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KN1_RS03450	COG1063	alcohol dehydrogenase
KN1_RS03460	COG1201	RNA secondary structure unwinding
KN1_RS03490	COG0463	Glycosyl transferase, family 2
KN1_RS03510	COG0006	proline dipeptidase activity
KN1_RS03515	COG0123	including yeast histone deacetylase and acetoin utilization protein
KN1_RS03535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KN1_RS03540	COG0351	phosphomethylpyrimidine kinase
KN1_RS03550	COG1215	transferase activity, transferring glycosyl groups
KN1_RS03615	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KN1_RS03650	COG0674	pyruvate-flavodoxin oxidoreductase activity
KN1_RS03650	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KN1_RS03655	COG1013	pyruvate-flavodoxin oxidoreductase activity
KN1_RS03670	COG0277	FAD linked oxidase domain protein
KN1_RS03675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KN1_RS03680	COG1192	Involved in chromosome partitioning
KN1_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
KN1_RS03715	COG1331	Highly conserved protein containing a thioredoxin domain
KN1_RS03725	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KN1_RS03730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KN1_RS03770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KN1_RS03775	COG0083	homoserine kinase activity
KN1_RS03780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KN1_RS03785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KN1_RS03790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KN1_RS03795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KN1_RS03805	COG3958	Transketolase
KN1_RS03810	COG3959	Transketolase, thiamine diphosphate binding domain
KN1_RS03815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KN1_RS03845	COG1185	polyribonucleotide nucleotidyltransferase activity
KN1_RS03880	COG1960	acyl-CoA dehydrogenase activity
KN1_RS03885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KN1_RS03905	COG0433	COG0433 Predicted ATPase
KN1_RS03915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KN1_RS03925	COG2222	sugar isomerase
KN1_RS03930	COG0215	cysteine-tRNA ligase activity
KN1_RS03935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KN1_RS03960	COG1648	precorrin-2 dehydrogenase activity
KN1_RS03960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KN1_RS03980	COG0402	S-adenosylhomocysteine deaminase activity
KN1_RS04005	COG0430	RNA-3'-phosphate cyclase activity
KN1_RS04020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KN1_RS04035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KN1_RS04050	COG3276	selenocysteine insertion sequence binding
KN1_RS04060	COG0071	Belongs to the small heat shock protein (HSP20) family
KN1_RS04070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KN1_RS04070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KN1_RS04075	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KN1_RS04095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KN1_RS04105	COG0492	ferredoxin-NADP+ reductase activity
KN1_RS04150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KN1_RS04180	COG1131	(ABC) transporter
KN1_RS04190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KN1_RS04220	COG2814	Major facilitator Superfamily
KN1_RS04260	COG1968	undecaprenyl-diphosphatase activity
KN1_RS04275	COG1960	acyl-CoA dehydrogenase activity
KN1_RS04300	COG3511	phospholipase C
KN1_RS04310	COG1073	alpha beta
KN1_RS04310	COG2226	methyltransferase
KN1_RS04320	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KN1_RS04430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KN1_RS04450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KN1_RS04475	COG4274	PFAM GYD family protein
KN1_RS04480	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KN1_RS04495	COG1573	uracil-dna glycosylase
KN1_RS04530	COG1953	Uracil, thiamine, allantoin
KN1_RS04535	COG1250	3-hydroxyacyl-CoA dehydrogenase
KN1_RS04555	COG1024	Enoyl-CoA hydratase
KN1_RS04570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KN1_RS04585	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KN1_RS04620	COG0328	RNA-DNA hybrid ribonuclease activity
KN1_RS04665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KN1_RS04685	COG1960	acyl-CoA dehydrogenase activity
KN1_RS04690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KN1_RS04735	COG1505	serine-type exopeptidase activity
KN1_RS04820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KN1_RS04925	COG0655	NAD(P)H dehydrogenase (quinone) activity
KN1_RS05055	COG0604	alcohol dehydrogenase
KN1_RS05100	COG0477	Major facilitator Superfamily
KN1_RS05115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KN1_RS05160	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KN1_RS05175	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KN1_RS05355	COG4555	ABC transporter
KN1_RS05390	COG0714	Associated with various cellular activities
KN1_RS05475	COG2815	serine threonine protein kinase
KN1_RS05475	COG0515	serine threonine protein kinase
KN1_RS05525	COG0515	serine threonine protein kinase
KN1_RS05525	COG2815	serine threonine protein kinase
KN1_RS05705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KN1_RS05735	COG1473	amidohydrolase
KN1_RS05745	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KN1_RS05790	COG0515	serine threonine protein kinase
KN1_RS05800	COG1373	ATPase (AAA superfamily
KN1_RS05855	COG1131	(ABC) transporter
KN1_RS05865	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KN1_RS05875	COG0028	Belongs to the TPP enzyme family
KN1_RS05895	COG2814	Major facilitator Superfamily
KN1_RS05925	COG1122	ATPase activity
KN1_RS05990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KN1_RS06010	COG0393	Putative heavy-metal-binding
KN1_RS06025	COG2301	Belongs to the HpcH HpaI aldolase family
KN1_RS06050	COG2271	Major facilitator Superfamily
KN1_RS06110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KN1_RS06135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KN1_RS06150	COG4608	Belongs to the ABC transporter superfamily
KN1_RS06155	COG0444	Belongs to the ABC transporter superfamily
KN1_RS06160	COG0601	transmembrane transport
KN1_RS06355	COG2815	serine threonine protein kinase
KN1_RS06355	COG0515	serine threonine protein kinase
KN1_RS06440	COG1373	ATPase (AAA superfamily
KN1_RS06465	COG1028	Short-chain dehydrogenase reductase Sdr
KN1_RS06475	COG2721	sulfolactate sulfo-lyase activity
KN1_RS06480	COG2721	sulfolactate sulfo-lyase activity
KN1_RS06490	COG1802	Transcriptional regulator
KN1_RS06655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KN1_RS06690	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KN1_RS06730	COG1518	maintenance of DNA repeat elements
KN1_RS06750	COG2409	Drug exporters of the RND superfamily
KN1_RS06765	COG4948	Mandelate Racemase Muconate Lactonizing
KN1_RS06770	COG1012	belongs to the aldehyde dehydrogenase family
KN1_RS06810	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KN1_RS06820	COG0477	Major facilitator Superfamily
KN1_RS06830	COG1012	belongs to the aldehyde dehydrogenase family
KN1_RS06835	COG2814	Major facilitator Superfamily
KN1_RS06865	COG2271	Major facilitator Superfamily
KN1_RS06970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KN1_RS06980	COG3383	formate dehydrogenase (NAD+) activity
KN1_RS07010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KN1_RS07020	COG0531	amino acid
KN1_RS07040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KN1_RS07060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KN1_RS07065	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
KN1_RS07095	COG4946	Tricorn protease homolog
KN1_RS07095	COG0823	Involved in the tonB-independent uptake of proteins
KN1_RS07095	COG1506	peptidase
KN1_RS07105	COG1012	belongs to the aldehyde dehydrogenase family
KN1_RS07120	COG3387	PFAM Glycoside hydrolase 15-related
KN1_RS07125	COG0693	protein deglycase activity
KN1_RS07140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KN1_RS07155	COG1012	belongs to the aldehyde dehydrogenase family
KN1_RS07160	COG0531	amino acid
KN1_RS07275	COG3387	PFAM Glycoside hydrolase 15-related
KN1_RS07280	COG0438	transferase activity, transferring glycosyl groups
KN1_RS07290	COG0813	purine-nucleoside phosphorylase activity
KN1_RS07370	COG1252	NADH dehydrogenase
KN1_RS07380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KN1_RS07385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KN1_RS07390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KN1_RS07405	COG0045	succinate-CoA ligase (ADP-forming) activity
KN1_RS07435	COG1185	polyribonucleotide nucleotidyltransferase activity
KN1_RS07470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KN1_RS07480	COG1234	tRNA 3'-trailer cleavage
KN1_RS07495	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KN1_RS07530	COG0300	oxidoreductase activity
KN1_RS07545	COG0477	Major facilitator Superfamily
KN1_RS07560	COG2814	Major facilitator Superfamily
KN1_RS07575	COG0650	Formate hydrogenlyase subunit 4
KN1_RS07585	COG0651	ATP synthesis coupled electron transport
KN1_RS07595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KN1_RS07600	COG1007	ATP synthesis coupled electron transport
KN1_RS07605	COG1846	Transcriptional regulator
KN1_RS07610	COG2814	Major facilitator Superfamily
KN1_RS07615	COG0438	transferase activity, transferring glycosyl groups
KN1_RS07625	COG0778	Nitroreductase
KN1_RS07655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KN1_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
KN1_RS07665	COG1573	uracil-dna glycosylase
KN1_RS07690	COG0495	leucyl-tRNA aminoacylation
KN1_RS07700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KN1_RS07720	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
KN1_RS07740	COG1131	(ABC) transporter
KN1_RS07750	COG0475	glutathione-regulated potassium exporter activity
KN1_RS07770	COG0488	(ABC) transporter
KN1_RS07780	COG2814	Major facilitator Superfamily
KN1_RS07820	COG1013	pyruvate-flavodoxin oxidoreductase activity
KN1_RS07840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KN1_RS07860	COG0037	tRNA processing
KN1_RS07895	COG0515	serine threonine protein kinase
KN1_RS07900	COG0243	molybdopterin cofactor binding
KN1_RS07910	COG2086	electron transfer activity
KN1_RS07920	COG0644	oxidoreductase
KN1_RS07930	COG2814	Major facilitator Superfamily
KN1_RS07950	COG0446	pyridine nucleotide-disulphide oxidoreductase
KN1_RS07985	COG0730	response to heat
KN1_RS07995	COG0402	S-adenosylhomocysteine deaminase activity
KN1_RS08055	COG3830	Belongs to the UPF0237 family
KN1_RS08060	COG2848	UPF0210 protein
KN1_RS08135	COG2814	Major facilitator Superfamily
KN1_RS08155	COG3276	selenocysteine insertion sequence binding
KN1_RS08180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KN1_RS08180	COG1648	precorrin-2 dehydrogenase activity
KN1_RS08185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KN1_RS08190	COG0113	porphobilinogen synthase activity
KN1_RS08195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KN1_RS08200	COG0181	hydroxymethylbilane synthase activity
KN1_RS08225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KN1_RS08235	COG1793	dna ligase
KN1_RS08240	COG0717	Belongs to the dCTP deaminase family
KN1_RS08255	COG2078	PFAM AMMECR1 domain protein
KN1_RS08285	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
KN1_RS08300	COG0504	CTP synthase activity
KN1_RS08325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KN1_RS08360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KN1_RS08365	COG0456	acetyltransferase
KN1_RS08410	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KN1_RS08420	COG1047	Peptidyl-prolyl cis-trans
KN1_RS08425	COG0371	Dehydrogenase
KN1_RS08430	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KN1_RS08465	COG0778	Nitroreductase
KN1_RS08475	COG0066	3-isopropylmalate dehydratase activity
KN1_RS08480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KN1_RS08485	COG0805	protein transport
KN1_RS08495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KN1_RS08500	COG1116	anion transmembrane transporter activity
KN1_RS08510	COG0439	Biotin carboxylase
KN1_RS08520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KN1_RS08525	COG4581	dead DEAH box helicase
KN1_RS08545	COG0372	Belongs to the citrate synthase family
KN1_RS08560	COG0450	alkyl hydroperoxide reductase
KN1_RS08570	COG1335	isochorismatase
KN1_RS08575	COG1515	deoxyribonuclease V activity
KN1_RS08585	COG0277	FAD linked oxidase domain protein
KN1_RS08590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KN1_RS08605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KN1_RS08610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KN1_RS08620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KN1_RS08630	COG0157	Belongs to the NadC ModD family
KN1_RS08640	COG0028	Belongs to the TPP enzyme family
KN1_RS08665	COG0017	Asparaginyl-tRNA synthetase
KN1_RS08690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KN1_RS08700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KN1_RS08700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KN1_RS08800	COG0315	cyclic pyranopterin monophosphate synthase activity
KN1_RS08805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KN1_RS08815	COG1881	PFAM PEBP family protein
KN1_RS08820	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KN1_RS08850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KN1_RS08870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KN1_RS08875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KN1_RS08880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KN1_RS08885	COG0189	ligase activity
KN1_RS08895	COG1522	sequence-specific DNA binding
KN1_RS08905	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KN1_RS08920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KN1_RS08960	COG0051	transcription antitermination factor activity, RNA binding
KN1_RS08965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KN1_RS08970	COG0049	tRNA binding
KN1_RS08985	COG0195	Participates in both transcription termination and antitermination
KN1_RS08995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KN1_RS09000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KN1_RS09005	COG0085	RNA polymerase activity
KN1_RS09015	COG0281	malic enzyme
KN1_RS09020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KN1_RS09025	COG0105	UTP biosynthetic process
KN1_RS09040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KN1_RS09045	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KN1_RS09050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KN1_RS09060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KN1_RS09065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KN1_RS09080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KN1_RS09095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KN1_RS09100	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
KN1_RS09100	COG0644	oxidoreductase
KN1_RS09105	COG1522	sequence-specific DNA binding
KN1_RS09110	COG0077	Prephenate dehydratase
KN1_RS09115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KN1_RS09150	COG1056	cytidyltransferase-related domain
KN1_RS09150	COG1051	belongs to the nudix hydrolase family
KN1_RS09190	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KN1_RS09230	COG1980	fructose-bisphosphate aldolase activity
KN1_RS09255	COG0459	protein refolding
KN1_RS09270	COG0124	histidyl-tRNA synthetase
KN1_RS09275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KN1_RS09305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KN1_RS09315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KN1_RS09350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KN1_RS09380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KN1_RS09385	COG2264	protein methyltransferase activity
KN1_RS09390	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
KN1_RS09400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KN1_RS09445	COG1185	polyribonucleotide nucleotidyltransferase activity
KN1_RS09450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KN1_RS09475	COG0322	excinuclease ABC activity
KN1_RS09485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KN1_RS09505	COG0473	3-isopropylmalate dehydrogenase activity
KN1_RS09520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KN1_RS09530	COG0089	rRNA binding
KN1_RS09535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KN1_RS09540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KN1_RS09545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KN1_RS09555	COG0255	Belongs to the universal ribosomal protein uL29 family
KN1_RS09565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KN1_RS09570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KN1_RS09575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KN1_RS09595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KN1_RS09620	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KN1_RS09655	COG0563	adenylate kinase activity
KN1_RS09680	COG0438	transferase activity, transferring glycosyl groups
KN1_RS09710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KN1_RS09715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KN1_RS09725	COG1201	RNA secondary structure unwinding
KN1_RS09745	COG0402	S-adenosylhomocysteine deaminase activity
KN1_RS09790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KN1_RS09835	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
KN1_RS09840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KN1_RS09845	COG1110	DNA topoisomerase II activity
KN1_RS09890	COG0667	Aldo Keto reductase
KN1_RS09895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KN1_RS09920	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
KN1_RS09930	COG0163	prenyltransferase activity
KN1_RS09960	COG0423	glycine-tRNA ligase activity
KN1_RS09965	COG0010	Belongs to the arginase family
KN1_RS10075	COG0023	Translation Initiation Factor
KN1_RS10090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KN1_RS10125	COG1280	lysine exporter protein (LysE YggA)
KN1_RS10145	COG0489	protein tyrosine kinase activity
KN1_RS10165	COG1994	Peptidase M50
KN1_RS10195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KN1_RS10200	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KN1_RS10215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KN1_RS10220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KN1_RS10220	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KN1_RS10230	COG0318	PFAM AMP-dependent synthetase and ligase
KN1_RS10235	COG3118	belongs to the thioredoxin family
KN1_RS10240	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KN1_RS10245	COG0174	glutamine synthetase
KN1_RS10260	COG0006	proline dipeptidase activity
KN1_RS10265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KN1_RS10285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KN1_RS10350	COG0552	protein localization to endoplasmic reticulum
KN1_RS10365	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KN1_RS10375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KN1_RS10385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KN1_RS10495	COG4581	dead DEAH box helicase
KN1_RS10545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KN1_RS10585	COG1122	ATPase activity
KN1_RS10595	COG3511	phospholipase C
KN1_RS10635	COG1113	amino acid transport
KN1_RS10685	COG1215	transferase activity, transferring glycosyl groups
KN1_RS10705	COG1446	asparaginase
KN1_RS10735	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KN1_RS10765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KN1_RS10770	COG0730	response to heat
KN1_RS10790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KN1_RS10790	COG1648	precorrin-2 dehydrogenase activity
KN1_RS10860	COG0515	serine threonine protein kinase
KN1_RS10860	COG2815	serine threonine protein kinase
KN1_RS10870	COG3386	PFAM SMP-30 Gluconolaconase
KN1_RS10895	COG0243	molybdopterin cofactor binding
KN1_RS10900	COG0437	4 iron, 4 sulfur cluster binding
KN1_RS10935	COG0438	transferase activity, transferring glycosyl groups
KN1_RS10940	COG0577	efflux transmembrane transporter activity
KN1_RS10945	COG4591	ABC-type transport system involved in lipoprotein release permease component
KN1_RS10955	COG1136	(ABC) transporter
KN1_RS10965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KN1_RS10975	COG1024	Enoyl-CoA hydratase
KN1_RS10990	COG1131	(ABC) transporter
KN1_RS11000	COG0039	L-malate dehydrogenase activity
KN1_RS11005	COG2079	MmgE PrpD family protein
KN1_RS11010	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KN1_RS11020	COG0372	Belongs to the citrate synthase family
KN1_RS11065	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
KN1_RS11075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KN1_RS11095	COG1121	(ABC) transporter
KN1_RS11100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KN1_RS11110	COG0501	Belongs to the peptidase M48B family
KN1_RS11160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KN1_RS11175	COG2271	Major facilitator Superfamily
KN1_RS11195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KN1_RS11200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KN1_RS11225	COG0515	serine threonine protein kinase
KN1_RS11225	COG2815	serine threonine protein kinase
KN1_RS11230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KN1_RS11250	COG0516	GMP reductase activity
KN1_RS11250	COG0517	IMP dehydrogenase activity
KN1_RS11265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KN1_RS11275	COG0297	glycogen (starch) synthase activity
KN1_RS11280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KN1_RS11360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KN1_RS11385	COG1063	alcohol dehydrogenase
KN1_RS11390	COG0179	Fumarylacetoacetate (FAA) hydrolase
KN1_RS11395	COG1122	ATPase activity
KN1_RS11450	COG2226	methyltransferase
KN1_RS11460	COG0515	serine threonine protein kinase
KN1_RS11470	COG4608	Belongs to the ABC transporter superfamily
KN1_RS11475	COG0444	Belongs to the ABC transporter superfamily
KN1_RS11480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KN1_RS11485	COG0601	transmembrane transport
KN1_RS11540	COG0584	glycerophosphoryl diester phosphodiesterase
KN1_RS11565	COG0004	ammonium transporteR
KN1_RS11595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KN1_RS11600	COG2860	membrane
KN1_RS11610	COG0477	Major facilitator Superfamily
KN1_RS11635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KN1_RS11640	COG2815	serine threonine protein kinase
KN1_RS11640	COG0515	serine threonine protein kinase
KN1_RS11645	COG2723	6-phospho-beta-galactosidase activity
KN1_RS11665	COG0415	Belongs to the DNA photolyase family
KN1_RS11715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KN1_RS11740	COG2814	Major facilitator Superfamily
KN1_RS11775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KN1_RS11815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KN1_RS11945	COG0154	amidase activity
KN1_RS11950	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KN1_RS11955	COG1324	tolerance protein
KN1_RS11965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KN1_RS11990	COG1110	DNA topoisomerase II activity
KN1_RS12000	COG1201	RNA secondary structure unwinding
KN1_RS12035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KN1_RS12040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KN1_RS12050	COG1028	Short-chain dehydrogenase reductase Sdr
KN1_RS12060	COG0528	UMP kinase activity
KN1_RS12070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KN1_RS12080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KN1_RS12130	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
KN1_RS12165	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KN1_RS12180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KN1_RS12185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KN1_RS12200	COG0018	arginyl-trna synthetase
KN1_RS12225	COG0459	protein refolding
KN1_RS12260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KN1_RS12280	COG0527	aspartate kinase activity
KN1_RS12280	COG0460	homoserine dehydrogenase
KN1_RS12305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KN1_RS12305	COG0574	Belongs to the PEP-utilizing enzyme family
KN1_RS12315	COG1254	Belongs to the acylphosphatase family
KN1_RS12320	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
KN1_RS12325	COG0159	tryptophan synthase activity
KN1_RS12330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KN1_RS12335	COG0135	phosphoribosylanthranilate isomerase activity
KN1_RS12340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KN1_RS12345	COG0512	Glutamine amidotransferase of anthranilate synthase
KN1_RS12345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KN1_RS12350	COG0134	indole-3-glycerol-phosphate synthase activity
KN1_RS12355	COG0436	Aminotransferase
KN1_RS12360	COG0525	valine-tRNA ligase activity
KN1_RS12395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KN1_RS12410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KN1_RS12460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KN1_RS12465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KN1_RS12485	COG0148	phosphopyruvate hydratase activity
KN1_RS12500	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KN1_RS12505	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KN1_RS12510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KN1_RS12515	COG0509	glycine decarboxylation via glycine cleavage system
KN1_RS12535	COG0396	ATPase activity
KN1_RS12540	COG0719	Fe-S assembly protein
KN1_RS12545	COG0719	Fe-S assembly protein
KN1_RS12560	COG1252	NADH dehydrogenase
KN1_RS12700	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KN1_RS12725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KN1_RS12765	COG4962	Type ii secretion system protein e
KN1_RS12800	COG1201	RNA secondary structure unwinding
KN1_RS12835	COG1058	Belongs to the CinA family
KN1_RS12835	COG1546	Belongs to the CinA family
KN1_RS12840	COG2267	carboxylic ester hydrolase activity
KN1_RS12845	COG0072	phenylalanine-tRNA ligase activity
KN1_RS12855	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KN1_RS12880	COG1078	dGTPase activity
KN1_RS12890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KN1_RS12910	COG0417	DNA replication proofreading
KN1_RS12920	COG2264	protein methyltransferase activity
KN1_RS12940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KN1_RS12960	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
KN1_RS12970	COG1394	ATPase activity, coupled to movement of substances
KN1_RS12985	COG0442	prolyl-tRNA aminoacylation
KN1_RS12995	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KN1_RS13000	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KN1_RS13015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KN1_RS13025	COG0028	Belongs to the TPP enzyme family
KN1_RS13035	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KN1_RS13045	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KN1_RS13060	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KN1_RS13070	COG0037	tRNA processing
KN1_RS13080	COG0495	leucyl-tRNA aminoacylation
KN1_RS13090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KN1_RS13095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KN1_RS13100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KN1_RS13105	COG0131	Imidazoleglycerol-phosphate dehydratase
KN1_RS13110	COG0107	imidazoleglycerol-phosphate synthase activity
KN1_RS13115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KN1_RS13125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KN1_RS13130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KN1_RS13135	COG2151	metal-sulfur cluster biosynthetic enzyme
KN1_RS13140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KN1_RS13145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KN1_RS13155	COG0537	adenosine 5'-monophosphoramidase activity
KN1_RS13165	COG1522	sequence-specific DNA binding
KN1_RS13185	COG0167	dihydroorotate dehydrogenase activity
KN1_RS13190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KN1_RS13200	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
KN1_RS13205	COG0540	Belongs to the ATCase OTCase family
KN1_RS13210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KN1_RS13255	COG0602	queuosine metabolic process
KN1_RS13260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KN1_RS13265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KN1_RS13265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KN1_RS13270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KN1_RS13280	COG0047	phosphoribosylformylglycinamidine synthase activity
KN1_RS13285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KN1_RS13290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KN1_RS13295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KN1_RS13300	COG0151	Belongs to the GarS family
KN1_RS13305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KN1_RS13320	COG0137	argininosuccinate synthase activity
KN1_RS13325	COG0165	Argininosuccinate lyase
KN1_RS13335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KN1_RS13340	COG0189	ligase activity
KN1_RS13350	COG1250	3-hydroxyacyl-CoA dehydrogenase
KN1_RS13400	COG0109	protoheme IX farnesyltransferase activity
KN1_RS13400	COG1612	heme a metabolic process
KN1_RS13405	COG0460	homoserine dehydrogenase
KN1_RS13415	COG0864	Transcriptional regulator
KN1_RS13420	COG0312	modulator of DNA gyrase
KN1_RS13440	COG0009	L-threonylcarbamoyladenylate synthase
KN1_RS13465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KN1_RS13465	COG1042	CoA-binding domain protein
KN1_RS13465	COG0045	succinate-CoA ligase (ADP-forming) activity
KN1_RS13470	COG0469	pyruvate kinase activity
KN1_RS13505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KN1_RS13525	COG1061	Type III restriction enzyme res subunit
KN1_RS13545	COG0444	Belongs to the ABC transporter superfamily
KN1_RS13580	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KN1_RS13590	COG2226	methyltransferase
KN1_RS13595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KN1_RS13620	COG1139	Iron-sulfur cluster binding protein
KN1_RS13665	COG1960	acyl-CoA dehydrogenase activity
KN1_RS13690	COG0501	Belongs to the peptidase M48B family
KN1_RS13745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KN1_RS13750	COG2329	Antibiotic biosynthesis monooxygenase
KN1_RS13860	COG0531	amino acid
KN1_RS13865	COG2271	Major facilitator Superfamily
KN1_RS13900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KN1_RS13945	COG2124	cytochrome p450
KN1_RS13950	COG3842	ATPase activity
KN1_RS13955	COG0395	ABC-type sugar transport system, permease component
KN1_RS13960	COG1175	transmembrane transport
KN1_RS13970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KN1_RS13975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KN1_RS13980	COG4948	Mandelate Racemase Muconate Lactonizing
KN1_RS13985	COG2814	Major facilitator Superfamily
KN1_RS13995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KN1_RS14020	COG2368	4-hydroxyphenylacetate
KN1_RS14040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KN1_RS14045	COG1584	GPR1 FUN34 yaaH family protein
KN1_RS14050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KN1_RS14075	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KN1_RS14095	COG0437	4 iron, 4 sulfur cluster binding
KN1_RS14100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KN1_RS14105	COG1144	Oxidoreductase
KN1_RS14110	COG0674	pyruvate-flavodoxin oxidoreductase activity
KN1_RS14115	COG1013	pyruvate-flavodoxin oxidoreductase activity
KN1_RS14125	COG0277	FAD linked oxidase domain protein
KN1_RS14140	COG2271	Major facilitator Superfamily
KN1_RS14170	COG2235	arginine
KN1_RS14185	COG0243	molybdopterin cofactor binding
KN1_RS14190	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
KN1_RS14195	COG0277	FAD linked oxidase domain protein
KN1_RS14205	COG0402	S-adenosylhomocysteine deaminase activity
KN1_RS14250	COG0402	S-adenosylhomocysteine deaminase activity
KN1_RS14260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KN1_RS14260	COG2080	2 iron, 2 sulfur cluster binding
KN1_RS14270	COG0402	S-adenosylhomocysteine deaminase activity
KN1_RS14275	COG1522	sequence-specific DNA binding
KN1_RS14290	COG2308	Evidence 4 Homologs of previously reported genes of
KN1_RS14305	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KN1_RS14320	COG0804	urea catabolic process
KN1_RS14325	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KN1_RS14330	COG0830	nickel cation binding
KN1_RS14335	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KN1_RS14345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KN1_RS14350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KN1_RS14355	COG1953	Uracil, thiamine, allantoin
KN1_RS14380	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KN1_RS14405	COG0402	S-adenosylhomocysteine deaminase activity
KN1_RS14410	COG0277	FAD linked oxidase domain protein
KN1_RS14450	COG1121	(ABC) transporter
KN1_RS14470	COG0436	Aminotransferase
KN1_RS14490	COG0167	dihydroorotate dehydrogenase activity
KN1_RS14500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KN1_RS14510	COG1953	Uracil, thiamine, allantoin
KN1_RS14650	COG1442	glycosyl transferase family 8
KN1_RS14650	COG1216	Glycosyl transferase, family 2
KN1_RS14740	COG2304	oxidoreductase activity
KN1_RS14945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family