locus-tag	class	description
DSM109990_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DSM109990_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DSM109990_RS00070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DSM109990_RS00095	COG0443	Heat shock 70 kDa protein
DSM109990_RS00100	COG0484	heat shock protein binding
DSM109990_RS00105	COG2003	Belongs to the UPF0758 family
DSM109990_RS00120	COG0653	protein targeting
DSM109990_RS00125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM109990_RS00130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DSM109990_RS00135	COG0494	nUDIX hydrolase
DSM109990_RS00140	COG1597	lipid kinase activity
DSM109990_RS00150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DSM109990_RS00165	COG0779	Required for maturation of 30S ribosomal subunits
DSM109990_RS00170	COG4533	DNA binding
DSM109990_RS00180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM109990_RS00190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSM109990_RS00230	COG3034	peptidoglycan biosynthetic process
DSM109990_RS00235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DSM109990_RS00240	COG1132	(ABC) transporter
DSM109990_RS00245	COG1132	(ABC) transporter
DSM109990_RS00250	COG0617	tRNA 3'-terminal CCA addition
DSM109990_RS00255	COG0494	nUDIX hydrolase
DSM109990_RS00265	COG0494	nUDIX hydrolase
DSM109990_RS00270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM109990_RS00275	COG0137	argininosuccinate synthase activity
DSM109990_RS00290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM109990_RS00295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM109990_RS00300	COG0280	phosphate acetyltransferase
DSM109990_RS00300	COG0281	malic enzyme
DSM109990_RS00305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DSM109990_RS00310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DSM109990_RS00320	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DSM109990_RS00325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DSM109990_RS00330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DSM109990_RS00345	COG0357	Ribosomal RNA small subunit methyltransferase G
DSM109990_RS00350	COG0445	tRNA wobble uridine modification
DSM109990_RS00355	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DSM109990_RS00360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DSM109990_RS00365	COG1981	membrane
DSM109990_RS00370	COG0424	maF-like protein
DSM109990_RS00375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DSM109990_RS00380	COG0237	dephospho-CoA kinase activity
DSM109990_RS00385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DSM109990_RS00390	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DSM109990_RS00420	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DSM109990_RS00425	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DSM109990_RS00440	COG1074	ATP-dependent DNA helicase activity
DSM109990_RS00445	COG2887	Belongs to the helicase family. UvrD subfamily
DSM109990_RS00450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DSM109990_RS00455	COG3178	'Phosphotransferase
DSM109990_RS00460	COG0802	atpase or kinase
DSM109990_RS00475	COG1999	signal sequence binding
DSM109990_RS00480	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DSM109990_RS00490	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DSM109990_RS00500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DSM109990_RS00525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DSM109990_RS00530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DSM109990_RS00565	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DSM109990_RS00570	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DSM109990_RS00600	COG0174	glutamine synthetase
DSM109990_RS00615	COG3474	cytochrome
DSM109990_RS00620	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DSM109990_RS00625	COG0408	coproporphyrinogen oxidase activity
DSM109990_RS00630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DSM109990_RS00635	COG0181	hydroxymethylbilane synthase activity
DSM109990_RS00675	COG3191	aminopeptidase activity
DSM109990_RS00680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DSM109990_RS00685	COG1396	sequence-specific DNA binding
DSM109990_RS00705	COG0784	Response regulator, receiver
DSM109990_RS00730	COG1295	ribonuclease BN
DSM109990_RS00735	COG2116	formate transmembrane transporter activity
DSM109990_RS00760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS00795	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM109990_RS00805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM109990_RS00810	COG0693	protein deglycase activity
DSM109990_RS00820	COG2995	paraquat-inducible protein a
DSM109990_RS00825	COG3008	intermembrane lipid transfer
DSM109990_RS00825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DSM109990_RS00845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM109990_RS00850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM109990_RS00855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DSM109990_RS00860	COG1137	ATPase activity
DSM109990_RS00875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DSM109990_RS00875	COG0517	IMP dehydrogenase activity
DSM109990_RS00880	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DSM109990_RS00890	COG2030	dehydratase
DSM109990_RS00890	COG1012	belongs to the aldehyde dehydrogenase family
DSM109990_RS00895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DSM109990_RS00900	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM109990_RS00905	COG3396	Phenylacetate-CoA oxygenase
DSM109990_RS00910	COG3460	Phenylacetate-CoA oxygenase
DSM109990_RS00915	COG3396	Phenylacetate-CoA oxygenase
DSM109990_RS00930	COG0697	spore germination
DSM109990_RS00935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DSM109990_RS00940	COG4143	(ABC) transporter
DSM109990_RS00950	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DSM109990_RS00960	COG2808	Putative FMN-binding domain
DSM109990_RS00965	COG0625	glutathione transferase activity
DSM109990_RS00985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM109990_RS00990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DSM109990_RS01000	COG1177	transmembrane transport
DSM109990_RS01005	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM109990_RS01030	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS01045	COG1968	undecaprenyl-diphosphatase activity
DSM109990_RS01065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DSM109990_RS01075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DSM109990_RS01085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM109990_RS01090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM109990_RS01100	COG0776	regulation of translation
DSM109990_RS01105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DSM109990_RS01110	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DSM109990_RS01160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DSM109990_RS01165	COG0142	geranyltranstransferase activity
DSM109990_RS01170	COG1722	exodeoxyribonuclease VII activity
DSM109990_RS01175	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS01180	COG1846	Transcriptional regulator
DSM109990_RS01185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSM109990_RS01190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DSM109990_RS01210	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM109990_RS01210	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM109990_RS01220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM109990_RS01225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM109990_RS01235	COG3214	Protein conserved in bacteria
DSM109990_RS01240	COG1609	Transcriptional regulator
DSM109990_RS01250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM109990_RS01260	COG1063	alcohol dehydrogenase
DSM109990_RS01265	COG0246	Mannitol dehydrogenase
DSM109990_RS01275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM109990_RS01275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM109990_RS01280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM109990_RS01310	COG5002	protein histidine kinase activity
DSM109990_RS01310	COG5001	Diguanylate cyclase
DSM109990_RS01310	COG3447	MASE1 domain protein
DSM109990_RS01330	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS01335	COG0704	Plays a role in the regulation of phosphate uptake
DSM109990_RS01345	COG0581	inorganic phosphate transmembrane transporter activity
DSM109990_RS01350	COG0573	inorganic phosphate transmembrane transporter activity
DSM109990_RS01355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DSM109990_RS01365	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DSM109990_RS01370	COG3639	organic phosphonate transmembrane transporter activity
DSM109990_RS01380	COG0473	3-isopropylmalate dehydrogenase activity
DSM109990_RS01395	COG0066	3-isopropylmalate dehydratase activity
DSM109990_RS01405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSM109990_RS01410	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DSM109990_RS01410	COG3264	Mechanosensitive ion channel
DSM109990_RS01415	COG0799	negative regulation of ribosome biogenesis
DSM109990_RS01420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DSM109990_RS01430	COG0277	FAD linked oxidase domain protein
DSM109990_RS01435	COG0277	FAD linked oxidase domain protein
DSM109990_RS01445	COG0247	lactate metabolic process
DSM109990_RS01465	COG3443	Belongs to the bacterial solute-binding protein 9 family
DSM109990_RS01510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DSM109990_RS01515	COG2897	thiosulfate sulfurtransferase activity
DSM109990_RS01530	COG0004	ammonium transporteR
DSM109990_RS01545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM109990_RS01555	COG0584	glycerophosphoryl diester phosphodiesterase
DSM109990_RS01565	COG2154	pterin-4-alpha-carbinolamine dehydratase
DSM109990_RS01570	COG0668	transmembrane transport
DSM109990_RS01575	COG0678	peroxiredoxin activity
DSM109990_RS01585	COG0742	ribosomal rna small subunit methyltransferase
DSM109990_RS01620	COG0024	Methionine aminopeptidase
DSM109990_RS01625	COG1489	DNA binding
DSM109990_RS01630	COG1058	Belongs to the CinA family
DSM109990_RS01630	COG1546	Belongs to the CinA family
DSM109990_RS01660	COG2423	ornithine cyclodeaminase activity
DSM109990_RS01670	COG1671	Belongs to the UPF0178 family
DSM109990_RS01675	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DSM109990_RS01680	COG0679	Auxin Efflux Carrier
DSM109990_RS01700	COG2050	protein possibly involved in aromatic compounds catabolism
DSM109990_RS01710	COG0791	NLP P60 protein
DSM109990_RS01715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM109990_RS01725	COG0288	reversible hydration of carbon dioxide
DSM109990_RS01730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DSM109990_RS01750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DSM109990_RS01765	COG1194	a g-specific adenine glycosylase
DSM109990_RS01775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DSM109990_RS01785	COG1663	tetraacyldisaccharide 4'-kinase activity
DSM109990_RS01805	COG0312	modulator of DNA gyrase
DSM109990_RS01845	COG0495	leucyl-tRNA aminoacylation
DSM109990_RS01860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DSM109990_RS01875	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS01880	COG0708	Exodeoxyribonuclease III
DSM109990_RS01885	COG3118	belongs to the thioredoxin family
DSM109990_RS01895	COG2835	tetraacyldisaccharide 4'-kinase activity
DSM109990_RS01900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM109990_RS01905	COG0154	amidase activity
DSM109990_RS01910	COG0436	Aminotransferase
DSM109990_RS01915	COG1674	ftsk spoiiie
DSM109990_RS01935	COG0405	Gamma-glutamyltransferase
DSM109990_RS01950	COG0564	pseudouridine synthase activity
DSM109990_RS01955	COG0450	alkyl hydroperoxide reductase
DSM109990_RS01970	COG1185	polyribonucleotide nucleotidyltransferase activity
DSM109990_RS01975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DSM109990_RS02000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DSM109990_RS02010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DSM109990_RS02015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DSM109990_RS02050	COG0138	bifunctional purine biosynthesis protein purh
DSM109990_RS02055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DSM109990_RS02065	COG0612	Peptidase, M16
DSM109990_RS02070	COG0612	Peptidase, M16
DSM109990_RS02075	COG1012	belongs to the aldehyde dehydrogenase family
DSM109990_RS02085	COG0803	Belongs to the bacterial solute-binding protein 9 family
DSM109990_RS02090	COG1121	(ABC) transporter
DSM109990_RS02095	COG1321	iron dependent repressor
DSM109990_RS02095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSM109990_RS02100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSM109990_RS02105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DSM109990_RS02150	COG0625	glutathione transferase activity
DSM109990_RS02160	COG3383	formate dehydrogenase (NAD+) activity
DSM109990_RS02175	COG4191	Histidine kinase
DSM109990_RS02195	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM109990_RS02215	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DSM109990_RS02220	COG1178	ABC-type Fe3 transport system permease component
DSM109990_RS02225	COG1840	ABC-type Fe3 transport system, periplasmic component
DSM109990_RS02230	COG0625	glutathione transferase activity
DSM109990_RS02235	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DSM109990_RS02250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSM109990_RS02260	COG0284	orotidine-5'-phosphate decarboxylase activity
DSM109990_RS02280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DSM109990_RS02285	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DSM109990_RS02325	COG0250	Participates in transcription elongation, termination and antitermination
DSM109990_RS02330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DSM109990_RS02335	COG0081	regulation of translation
DSM109990_RS02340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DSM109990_RS02345	COG0222	ribosome binding
DSM109990_RS02350	COG0085	RNA polymerase activity
DSM109990_RS02355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DSM109990_RS02360	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS02375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DSM109990_RS02380	COG0049	tRNA binding
DSM109990_RS02385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DSM109990_RS02390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DSM109990_RS02395	COG0051	transcription antitermination factor activity, RNA binding
DSM109990_RS02400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DSM109990_RS02405	COG0088	Forms part of the polypeptide exit tunnel
DSM109990_RS02410	COG0089	rRNA binding
DSM109990_RS02420	COG3239	Fatty acid desaturase
DSM109990_RS02425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DSM109990_RS02430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DSM109990_RS02435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DSM109990_RS02440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DSM109990_RS02445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DSM109990_RS02470	COG0255	Belongs to the universal ribosomal protein uL29 family
DSM109990_RS02475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DSM109990_RS02480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DSM109990_RS02485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DSM109990_RS02490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DSM109990_RS02495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DSM109990_RS02500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DSM109990_RS02505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DSM109990_RS02510	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DSM109990_RS02515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DSM109990_RS02520	COG1841	ribosomal large subunit assembly
DSM109990_RS02525	COG0200	Binds to the 23S rRNA
DSM109990_RS02530	COG0201	protein transport
DSM109990_RS02535	COG0563	adenylate kinase activity
DSM109990_RS02540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DSM109990_RS02545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DSM109990_RS02550	COG0202	RNA polymerase activity
DSM109990_RS02555	COG0203	ribosomal protein L17
DSM109990_RS02560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DSM109990_RS02570	COG0564	pseudouridine synthase activity
DSM109990_RS02575	COG0546	phosphoglycolate phosphatase activity
DSM109990_RS02585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM109990_RS02590	COG4597	amino acid ABC transporter
DSM109990_RS02595	COG0765	amino acid transport
DSM109990_RS02600	COG1126	abc transporter atp-binding protein
DSM109990_RS02610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DSM109990_RS02615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DSM109990_RS02625	COG0706	membrane insertase activity
DSM109990_RS02630	COG5001	Diguanylate cyclase
DSM109990_RS02630	COG3300	MHYT domain
DSM109990_RS02635	COG0037	tRNA processing
DSM109990_RS02640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DSM109990_RS02645	COG0594	ribonuclease P activity
DSM109990_RS02650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DSM109990_RS02660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM109990_RS02695	COG2197	response regulator
DSM109990_RS02715	COG4607	ABC-type enterochelin transport system periplasmic component
DSM109990_RS02720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM109990_RS02725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM109990_RS02730	COG1120	ATPase activity
DSM109990_RS02735	COG4774	siderophore transport
DSM109990_RS02745	COG0501	Belongs to the peptidase M48B family
DSM109990_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS02765	COG0583	DNA-binding transcription factor activity
DSM109990_RS02775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM109990_RS02780	COG0765	amino acid transport
DSM109990_RS02790	COG5002	protein histidine kinase activity
DSM109990_RS02805	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS02810	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM109990_RS02815	COG2202	Pas domain
DSM109990_RS02815	COG2205	protein histidine kinase activity
DSM109990_RS02840	COG0411	ABC transporter
DSM109990_RS02850	COG2197	response regulator
DSM109990_RS02860	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS02860	COG2205	protein histidine kinase activity
DSM109990_RS02860	COG4191	Histidine kinase
DSM109990_RS02865	COG4566	intracellular signal transduction
DSM109990_RS02880	COG2205	protein histidine kinase activity
DSM109990_RS02885	COG1271	oxidase subunit
DSM109990_RS02890	COG1294	oxidase, subunit
DSM109990_RS02900	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS02900	COG0604	alcohol dehydrogenase
DSM109990_RS02900	COG3321	synthase
DSM109990_RS02905	COG0697	spore germination
DSM109990_RS02915	COG1131	(ABC) transporter
DSM109990_RS02920	COG0842	Transport permease protein
DSM109990_RS02935	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS02940	COG0322	excinuclease ABC activity
DSM109990_RS02945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DSM109990_RS02955	COG0314	molybdopterin synthase activity
DSM109990_RS02960	COG0346	lactoylglutathione lyase activity
DSM109990_RS02975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DSM109990_RS02995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DSM109990_RS03000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DSM109990_RS03010	COG0540	Belongs to the ATCase OTCase family
DSM109990_RS03015	COG1573	uracil-dna glycosylase
DSM109990_RS03020	COG1280	lysine exporter protein (LysE YggA)
DSM109990_RS03025	COG0521	Mo-molybdopterin cofactor biosynthetic process
DSM109990_RS03035	COG1678	Uncharacterized ACR, COG1678
DSM109990_RS03040	COG0009	L-threonylcarbamoyladenylate synthase
DSM109990_RS03045	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS03050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM109990_RS03080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DSM109990_RS03085	COG0746	molybdenum cofactor guanylyltransferase activity
DSM109990_RS03090	COG0303	'Molybdopterin
DSM109990_RS03100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSM109990_RS03115	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DSM109990_RS03120	COG0142	geranyltranstransferase activity
DSM109990_RS03130	COG2890	protein-(glutamine-N5) methyltransferase activity
DSM109990_RS03155	COG2818	Glycosylase
DSM109990_RS03160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DSM109990_RS03165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM109990_RS03170	COG0287	Prephenate dehydrogenase
DSM109990_RS03185	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DSM109990_RS03210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM109990_RS03220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM109990_RS03225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DSM109990_RS03230	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DSM109990_RS03235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DSM109990_RS03240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DSM109990_RS03260	COG2267	carboxylic ester hydrolase activity
DSM109990_RS03270	COG2983	Belongs to the UPF0260 family
DSM109990_RS03275	COG0196	riboflavin kinase activity
DSM109990_RS03280	COG2030	dehydratase
DSM109990_RS03290	COG1227	inorganic diphosphatase activity
DSM109990_RS03305	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DSM109990_RS03310	COG0459	protein refolding
DSM109990_RS03315	COG2201	protein-glutamate methylesterase activity
DSM109990_RS03320	COG4251	negative regulation of phosphorylation
DSM109990_RS03345	COG3454	Phosphonate metabolism
DSM109990_RS03350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DSM109990_RS03355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DSM109990_RS03365	COG0071	Belongs to the small heat shock protein (HSP20) family
DSM109990_RS03375	COG2046	Belongs to the sulfate adenylyltransferase family
DSM109990_RS03375	COG0529	Catalyzes the synthesis of activated sulfate
DSM109990_RS03380	COG0492	ferredoxin-NADP+ reductase activity
DSM109990_RS03385	COG1522	sequence-specific DNA binding
DSM109990_RS03400	COG1496	oxidoreductase activity
DSM109990_RS03410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DSM109990_RS03430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM109990_RS03435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM109990_RS03440	COG1435	thymidine kinase activity
DSM109990_RS03465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DSM109990_RS03470	COG0596	Alpha beta hydrolase
DSM109990_RS03485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSM109990_RS03490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DSM109990_RS03495	COG3237	CsbD-like
DSM109990_RS03505	COG0019	diaminopimelate decarboxylase activity
DSM109990_RS03525	COG0281	malic enzyme
DSM109990_RS03525	COG0280	phosphate acetyltransferase
DSM109990_RS03535	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DSM109990_RS03540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DSM109990_RS03545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DSM109990_RS03560	COG0318	PFAM AMP-dependent synthetase and ligase
DSM109990_RS03575	COG1024	Enoyl-CoA hydratase
DSM109990_RS03575	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM109990_RS03580	COG0183	Belongs to the thiolase family
DSM109990_RS03585	COG0625	glutathione transferase activity
DSM109990_RS03590	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS03600	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS03605	COG0789	Transcriptional regulator
DSM109990_RS03610	COG2197	response regulator
DSM109990_RS03635	COG0534	Mate efflux family protein
DSM109990_RS03645	COG0167	dihydroorotate dehydrogenase activity
DSM109990_RS03655	COG0737	Belongs to the 5'-nucleotidase family
DSM109990_RS03670	COG0583	DNA-binding transcription factor activity
DSM109990_RS03675	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS03680	COG0022	dehydrogenase e1 component
DSM109990_RS03685	COG4948	Mandelate Racemase Muconate Lactonizing
DSM109990_RS03690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM109990_RS03715	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DSM109990_RS03725	COG1643	Atp-dependent helicase
DSM109990_RS03730	COG1703	isobutyryl-CoA mutase activity
DSM109990_RS03755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DSM109990_RS03790	COG0632	four-way junction helicase activity
DSM109990_RS03795	COG2255	four-way junction helicase activity
DSM109990_RS03805	COG0824	Thioesterase
DSM109990_RS03825	COG0823	Involved in the tonB-independent uptake of proteins
DSM109990_RS03830	COG2885	chlorophyll binding
DSM109990_RS03840	COG0037	tRNA processing
DSM109990_RS03845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM109990_RS03860	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DSM109990_RS03865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DSM109990_RS03880	COG1201	RNA secondary structure unwinding
DSM109990_RS03930	COG4964	Belongs to the GSP D family
DSM109990_RS03955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DSM109990_RS03970	COG1754	DNA topoisomerase type I activity
DSM109990_RS03970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DSM109990_RS03975	COG0758	DNA mediated transformation
DSM109990_RS03980	COG0312	modulator of DNA gyrase
DSM109990_RS03990	COG0109	protoheme IX farnesyltransferase activity
DSM109990_RS04000	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DSM109990_RS04010	COG3346	SURF1 family
DSM109990_RS04035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DSM109990_RS04040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DSM109990_RS04045	COG0659	secondary active sulfate transmembrane transporter activity
DSM109990_RS04050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DSM109990_RS04065	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DSM109990_RS04070	COG4149	molybdate abc transporter
DSM109990_RS04075	COG0725	ABC transporter, periplasmic molybdate-binding protein
DSM109990_RS04100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM109990_RS04115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DSM109990_RS04150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM109990_RS04170	COG2010	Cytochrome c
DSM109990_RS04170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM109990_RS04200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DSM109990_RS04210	COG0601	transmembrane transport
DSM109990_RS04225	COG0747	negative chemotaxis
DSM109990_RS04250	COG3436	PFAM IS66 Orf2 family protein
DSM109990_RS04255	COG4372	Transposase
DSM109990_RS04280	COG1132	(ABC) transporter
DSM109990_RS04285	COG0318	PFAM AMP-dependent synthetase and ligase
DSM109990_RS04300	COG1490	D-aminoacyl-tRNA deacylase activity
DSM109990_RS04330	COG3853	Toxic anion resistance protein (TelA)
DSM109990_RS04350	COG0590	tRNA wobble adenosine to inosine editing
DSM109990_RS04365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DSM109990_RS04385	COG0154	amidase activity
DSM109990_RS04390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM109990_RS04395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DSM109990_RS04410	COG0670	Belongs to the BI1 family
DSM109990_RS04415	COG1396	sequence-specific DNA binding
DSM109990_RS04420	COG0483	inositol monophosphate 1-phosphatase activity
DSM109990_RS04435	COG0402	S-adenosylhomocysteine deaminase activity
DSM109990_RS04440	COG2239	Acts as a magnesium transporter
DSM109990_RS04445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DSM109990_RS04450	COG1692	metallophosphoesterase
DSM109990_RS04455	COG0471	metal ion transport
DSM109990_RS04455	COG3273	potassium ion transport
DSM109990_RS04460	COG0471	metal ion transport
DSM109990_RS04460	COG3273	potassium ion transport
DSM109990_RS04465	COG0217	transcriptional regulatory protein
DSM109990_RS04485	COG1309	transcriptional regulator
DSM109990_RS04505	COG3800	Transcriptional regulator
DSM109990_RS04505	COG1396	sequence-specific DNA binding
DSM109990_RS04510	COG2814	Major facilitator Superfamily
DSM109990_RS04515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM109990_RS04545	COG4770	biotin carboxylase activity
DSM109990_RS04555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM109990_RS04555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM109990_RS04565	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DSM109990_RS04580	COG0248	Ppx GppA phosphatase
DSM109990_RS04585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DSM109990_RS04595	COG0628	permease
DSM109990_RS04600	COG0442	prolyl-tRNA aminoacylation
DSM109990_RS04615	COG1136	(ABC) transporter
DSM109990_RS04630	COG0187	DNA topoisomerase II activity
DSM109990_RS04645	COG2267	carboxylic ester hydrolase activity
DSM109990_RS04650	COG0534	Mate efflux family protein
DSM109990_RS04675	COG1846	Transcriptional regulator
DSM109990_RS04705	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DSM109990_RS04715	COG1278	Cold shock
DSM109990_RS04720	COG1393	Belongs to the ArsC family
DSM109990_RS04735	COG3220	belongs to the UPF0276 family
DSM109990_RS04745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DSM109990_RS04770	COG3243	poly(R)-hydroxyalkanoic acid synthase
DSM109990_RS04785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM109990_RS04790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM109990_RS04795	COG0174	glutamine synthetase
DSM109990_RS04800	COG0519	Catalyzes the synthesis of GMP from XMP
DSM109990_RS04805	COG0174	glutamine synthetase
DSM109990_RS04810	COG4160	amino acid transport
DSM109990_RS04815	COG4215	(ABC) transporter
DSM109990_RS04845	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DSM109990_RS04850	COG0504	CTP synthase activity
DSM109990_RS04875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSM109990_RS04895	COG0697	spore germination
DSM109990_RS04910	COG0546	phosphoglycolate phosphatase activity
DSM109990_RS04970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DSM109990_RS04990	COG1215	transferase activity, transferring glycosyl groups
DSM109990_RS04995	COG0438	transferase activity, transferring glycosyl groups
DSM109990_RS05035	COG2010	Cytochrome c
DSM109990_RS05040	COG0348	domain, Protein
DSM109990_RS05065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM109990_RS05075	COG4191	Histidine kinase
DSM109990_RS05075	COG0784	Response regulator, receiver
DSM109990_RS05090	COG0625	glutathione transferase activity
DSM109990_RS05115	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DSM109990_RS05140	COG1741	Belongs to the pirin family
DSM109990_RS05145	COG1760	l-serine dehydratase
DSM109990_RS05150	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DSM109990_RS05160	COG0330	HflC and HflK could
DSM109990_RS05165	COG0330	HflC and HflK could
DSM109990_RS05195	COG0151	Belongs to the GarS family
DSM109990_RS05200	COG1570	exodeoxyribonuclease VII activity
DSM109990_RS05215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DSM109990_RS05220	COG0552	protein localization to endoplasmic reticulum
DSM109990_RS05225	COG1285	pathogenesis
DSM109990_RS05245	COG1469	GTP cyclohydrolase I activity
DSM109990_RS05255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM109990_RS05260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM109990_RS05265	COG0752	glycyl-tRNA synthetase alpha subunit
DSM109990_RS05280	COG0751	glycine-tRNA ligase activity
DSM109990_RS05285	COG0574	Belongs to the PEP-utilizing enzyme family
DSM109990_RS05285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM109990_RS05295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DSM109990_RS05300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DSM109990_RS05305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSM109990_RS05310	COG0697	spore germination
DSM109990_RS05315	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DSM109990_RS05345	COG1802	Transcriptional regulator
DSM109990_RS05355	COG0505	Belongs to the CarA family
DSM109990_RS05360	COG1610	YqeY-like protein
DSM109990_RS05375	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DSM109990_RS05380	COG1304	FMN binding
DSM109990_RS05390	COG0210	DNA helicase
DSM109990_RS05400	COG0489	protein tyrosine kinase activity
DSM109990_RS05410	COG2001	Belongs to the MraZ family
DSM109990_RS05415	COG0275	rRNA processing
DSM109990_RS05430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSM109990_RS05440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM109990_RS05450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DSM109990_RS05455	COG2081	HI0933 family
DSM109990_RS05470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DSM109990_RS05475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DSM109990_RS05495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DSM109990_RS05500	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM109990_RS05505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DSM109990_RS05510	COG0849	cell division
DSM109990_RS05515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DSM109990_RS05525	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM109990_RS05530	COG0497	DNA recombination
DSM109990_RS05545	COG0006	proline dipeptidase activity
DSM109990_RS05565	COG0484	heat shock protein binding
DSM109990_RS05585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM109990_RS05605	COG0308	aminopeptidase N
DSM109990_RS05615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DSM109990_RS05620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DSM109990_RS05625	COG1943	Transposase
DSM109990_RS05630	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS05650	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DSM109990_RS05665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS05670	COG0601	transmembrane transport
DSM109990_RS05680	COG4172	Belongs to the ABC transporter superfamily
DSM109990_RS05685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM109990_RS05695	COG1473	amidohydrolase
DSM109990_RS05700	COG1473	amidohydrolase
DSM109990_RS05710	COG1519	Transferase
DSM109990_RS05715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DSM109990_RS05735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DSM109990_RS05740	COG0546	phosphoglycolate phosphatase activity
DSM109990_RS05745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM109990_RS05755	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS05775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM109990_RS05780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM109990_RS05800	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DSM109990_RS05810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM109990_RS05815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM109990_RS05825	COG0649	NAD binding
DSM109990_RS05835	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM109990_RS05835	COG3743	rRNA binding
DSM109990_RS05870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DSM109990_RS05875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM109990_RS05890	COG0713	ATP synthesis coupled electron transport
DSM109990_RS05905	COG1007	ATP synthesis coupled electron transport
DSM109990_RS05915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DSM109990_RS05930	COG0513	Belongs to the DEAD box helicase family
DSM109990_RS05940	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DSM109990_RS05955	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS05970	COG3842	ATPase activity
DSM109990_RS05990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM109990_RS05995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM109990_RS06000	COG0805	protein transport
DSM109990_RS06010	COG1388	LysM domain
DSM109990_RS06010	COG0739	heme binding
DSM109990_RS06015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM109990_RS06020	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DSM109990_RS06025	COG0300	oxidoreductase activity
DSM109990_RS06045	COG0175	sulfate reduction
DSM109990_RS06050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DSM109990_RS06060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DSM109990_RS06060	COG1648	precorrin-2 dehydrogenase activity
DSM109990_RS06065	COG1522	sequence-specific DNA binding
DSM109990_RS06070	COG0149	triose-phosphate isomerase activity
DSM109990_RS06095	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM109990_RS06100	COG4067	protein conserved in archaea
DSM109990_RS06100	COG0189	ligase activity
DSM109990_RS06120	COG0343	queuine tRNA-ribosyltransferase activity
DSM109990_RS06125	COG1902	pentaerythritol trinitrate reductase activity
DSM109990_RS06130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM109990_RS06140	COG0406	alpha-ribazole phosphatase activity
DSM109990_RS06145	COG0406	alpha-ribazole phosphatase activity
DSM109990_RS06175	COG0156	8-amino-7-oxononanoate synthase activity
DSM109990_RS06185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DSM109990_RS06200	COG0436	Aminotransferase
DSM109990_RS06205	COG0860	N-Acetylmuramoyl-L-alanine amidase
DSM109990_RS06210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DSM109990_RS06215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DSM109990_RS06235	COG0028	Belongs to the TPP enzyme family
DSM109990_RS06240	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DSM109990_RS06260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DSM109990_RS06285	COG1764	response to oxidative stress
DSM109990_RS06305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM109990_RS06315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM109990_RS06330	COG0010	Belongs to the arginase family
DSM109990_RS06340	COG1238	metal cluster binding
DSM109990_RS06500	COG5410	chromosome segregation
DSM109990_RS06595	COG3645	SOS response
DSM109990_RS06595	COG3646	Phage regulatory protein
DSM109990_RS06665	COG0583	DNA-binding transcription factor activity
DSM109990_RS06700	COG0604	alcohol dehydrogenase
DSM109990_RS06700	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS06700	COG3321	synthase
DSM109990_RS06705	COG0318	PFAM AMP-dependent synthetase and ligase
DSM109990_RS06735	COG3842	ATPase activity
DSM109990_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS06760	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM109990_RS06765	COG3842	ATPase activity
DSM109990_RS06780	COG1984	allophanate hydrolase subunit 2
DSM109990_RS06790	COG0439	Biotin carboxylase
DSM109990_RS06800	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DSM109990_RS06805	COG0583	DNA-binding transcription factor activity
DSM109990_RS06810	COG0679	Auxin Efflux Carrier
DSM109990_RS06840	COG0747	negative chemotaxis
DSM109990_RS06845	COG0601	transmembrane transport
DSM109990_RS06850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS06870	COG3959	Transketolase, thiamine diphosphate binding domain
DSM109990_RS06875	COG3958	Transketolase
DSM109990_RS06885	COG1012	belongs to the aldehyde dehydrogenase family
DSM109990_RS06900	COG4681	YaeQ
DSM109990_RS06930	COG0798	PFAM Bile acid sodium symporter
DSM109990_RS06935	COG0431	NADPH-dependent FMN reductase
DSM109990_RS06960	COG1366	Belongs to the anti-sigma-factor antagonist family
DSM109990_RS06965	COG1366	Belongs to the anti-sigma-factor antagonist family
DSM109990_RS06970	COG4175	Glycine betaine
DSM109990_RS06970	COG0517	IMP dehydrogenase activity
DSM109990_RS06975	COG4176	ABC-type proline glycine betaine transport system permease component
DSM109990_RS07015	COG4536	flavin adenine dinucleotide binding
DSM109990_RS07025	COG4974	Belongs to the 'phage' integrase family
DSM109990_RS07040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DSM109990_RS07045	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DSM109990_RS07050	COG0629	single-stranded DNA binding
DSM109990_RS07055	COG0741	lytic transglycosylase activity
DSM109990_RS07065	COG4172	Belongs to the ABC transporter superfamily
DSM109990_RS07070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS07075	COG0601	transmembrane transport
DSM109990_RS07085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DSM109990_RS07090	COG0528	UMP kinase activity
DSM109990_RS07095	COG0233	cytoplasmic translational termination
DSM109990_RS07100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DSM109990_RS07110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DSM109990_RS07115	COG0750	zinc metalloprotease
DSM109990_RS07120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM109990_RS07130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM109990_RS07135	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM109990_RS07140	COG3494	Protein of unknown function (DUF1009)
DSM109990_RS07145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM109990_RS07150	COG0482	sulfurtransferase activity
DSM109990_RS07160	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS07165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DSM109990_RS07170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DSM109990_RS07180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DSM109990_RS07185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM109990_RS07195	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DSM109990_RS07200	COG1024	Enoyl-CoA hydratase
DSM109990_RS07215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM109990_RS07220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DSM109990_RS07225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DSM109990_RS07235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM109990_RS07240	COG1309	transcriptional regulator
DSM109990_RS07245	COG2326	polyphosphate kinase activity
DSM109990_RS07250	COG0596	Alpha beta hydrolase
DSM109990_RS07255	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DSM109990_RS07265	COG0697	spore germination
DSM109990_RS07305	COG0753	catalase activity
DSM109990_RS07310	COG0583	DNA-binding transcription factor activity
DSM109990_RS07320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DSM109990_RS07325	COG2010	Cytochrome c
DSM109990_RS07340	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DSM109990_RS07345	COG2867	negative regulation of translational initiation
DSM109990_RS07355	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DSM109990_RS07360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DSM109990_RS07360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DSM109990_RS07365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSM109990_RS07370	COG3852	Histidine kinase
DSM109990_RS07375	COG2204	response regulator
DSM109990_RS07380	COG5000	phosphorelay sensor kinase activity
DSM109990_RS07385	COG2204	response regulator
DSM109990_RS07395	COG0569	domain protein
DSM109990_RS07400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM109990_RS07405	COG1923	regulation of RNA biosynthetic process
DSM109990_RS07410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DSM109990_RS07420	COG1187	pseudouridine synthase activity
DSM109990_RS07430	COG2084	Dehydrogenase
DSM109990_RS07450	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DSM109990_RS07455	COG2814	Major facilitator Superfamily
DSM109990_RS07470	COG4166	transmembrane transport
DSM109990_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS07490	COG2313	pseudouridylate synthase activity
DSM109990_RS07520	COG1612	heme a metabolic process
DSM109990_RS07535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSM109990_RS07540	COG5425	PFAM Usg family protein
DSM109990_RS07550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DSM109990_RS07555	COG0363	glucosamine-6-phosphate deaminase activity
DSM109990_RS07560	COG0166	Belongs to the GPI family
DSM109990_RS07565	COG0318	PFAM AMP-dependent synthetase and ligase
DSM109990_RS07570	COG2205	protein histidine kinase activity
DSM109990_RS07570	COG2202	Pas domain
DSM109990_RS07580	COG2226	methyltransferase
DSM109990_RS07595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM109990_RS07595	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DSM109990_RS07610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DSM109990_RS07615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSM109990_RS07625	COG0671	phosphoesterase, PA-phosphatase related
DSM109990_RS07630	COG1217	gtp-binding protein TYPA
DSM109990_RS07640	COG1522	sequence-specific DNA binding
DSM109990_RS07650	COG0538	isocitrate dehydrogenase activity
DSM109990_RS07665	COG2945	thiolester hydrolase activity
DSM109990_RS07670	COG1959	2 iron, 2 sulfur cluster binding
DSM109990_RS07680	COG0719	Fe-S assembly protein
DSM109990_RS07685	COG0396	ATPase activity
DSM109990_RS07690	COG0719	Fe-S assembly protein
DSM109990_RS07705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DSM109990_RS07720	COG4589	Belongs to the CDS family
DSM109990_RS07730	COG3328	transposase activity
DSM109990_RS07740	COG0583	DNA-binding transcription factor activity
DSM109990_RS07745	COG2855	membrane
DSM109990_RS07750	COG1522	sequence-specific DNA binding
DSM109990_RS07780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DSM109990_RS07790	COG0248	Ppx GppA phosphatase
DSM109990_RS07795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DSM109990_RS07810	COG3257	ureidoglycine aminohydrolase activity
DSM109990_RS07820	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DSM109990_RS07830	COG2351	hydroxyisourate hydrolase activity
DSM109990_RS07835	COG0583	DNA-binding transcription factor activity
DSM109990_RS07855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DSM109990_RS07860	COG2011	ABC-type metal ion transport system permease component
DSM109990_RS07865	COG1464	Belongs to the NlpA lipoprotein family
DSM109990_RS07870	COG0235	Class ii aldolase
DSM109990_RS07875	COG3395	kinase activity
DSM109990_RS07920	COG0667	Aldo Keto reductase
DSM109990_RS07925	COG0569	domain protein
DSM109990_RS07930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM109990_RS07950	COG3794	PFAM blue (type 1) copper domain protein
DSM109990_RS07965	COG3811	Belongs to the UPF0386 family
DSM109990_RS07975	COG2814	Major facilitator Superfamily
DSM109990_RS07990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM109990_RS07995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM109990_RS08025	COG3743	rRNA binding
DSM109990_RS08025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM109990_RS08030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DSM109990_RS08040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DSM109990_RS08045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DSM109990_RS08050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DSM109990_RS08075	COG0052	Belongs to the universal ribosomal protein uS2 family
DSM109990_RS08080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DSM109990_RS08085	COG2771	luxR family
DSM109990_RS08090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DSM109990_RS08095	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS08105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DSM109990_RS08115	COG0573	inorganic phosphate transmembrane transporter activity
DSM109990_RS08125	COG5002	protein histidine kinase activity
DSM109990_RS08135	COG0194	GDP metabolic process
DSM109990_RS08140	COG1561	YicC-like family, N-terminal region
DSM109990_RS08150	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DSM109990_RS08160	COG2133	pyrroloquinoline quinone binding
DSM109990_RS08195	COG0433	COG0433 Predicted ATPase
DSM109990_RS08215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM109990_RS08235	COG1376	ErfK ybiS ycfS ynhG family protein
DSM109990_RS08255	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DSM109990_RS08255	COG3264	Mechanosensitive ion channel
DSM109990_RS08265	COG0494	nUDIX hydrolase
DSM109990_RS08275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSM109990_RS08280	COG0415	Belongs to the DNA photolyase family
DSM109990_RS08285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DSM109990_RS08290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSM109990_RS08300	COG0604	alcohol dehydrogenase
DSM109990_RS08305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM109990_RS08325	COG2186	Transcriptional regulator
DSM109990_RS08335	COG2059	Chromate
DSM109990_RS08345	COG0114	fumarate hydratase activity
DSM109990_RS08365	COG3588	fructose-bisphosphate aldolase
DSM109990_RS08370	COG2124	cytochrome p450
DSM109990_RS08380	COG0785	Cytochrome C biogenesis protein
DSM109990_RS08385	COG0425	Belongs to the sulfur carrier protein TusA family
DSM109990_RS08390	COG1530	ribonuclease E activity
DSM109990_RS08400	COG2204	response regulator
DSM109990_RS08410	COG0047	phosphoribosylformylglycinamidine synthase activity
DSM109990_RS08415	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM109990_RS08420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DSM109990_RS08430	COG0646	methionine synthase
DSM109990_RS08430	COG1410	methionine synthase
DSM109990_RS08440	COG5012	cobalamin binding
DSM109990_RS08450	COG2166	iron-sulfur cluster assembly
DSM109990_RS08460	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DSM109990_RS08465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DSM109990_RS08470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DSM109990_RS08500	COG0105	UTP biosynthetic process
DSM109990_RS08505	COG0488	(ABC) transporter
DSM109990_RS08510	COG2095	MarC family integral membrane protein
DSM109990_RS08515	COG3577	Aspartyl protease
DSM109990_RS08530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM109990_RS08545	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DSM109990_RS08555	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DSM109990_RS08560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DSM109990_RS08575	COG2890	protein-(glutamine-N5) methyltransferase activity
DSM109990_RS08580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DSM109990_RS08595	COG0010	Belongs to the arginase family
DSM109990_RS08600	COG1473	amidohydrolase
DSM109990_RS08605	COG3956	TIGRFAM MazG family protein
DSM109990_RS08620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DSM109990_RS08630	COG0513	Belongs to the DEAD box helicase family
DSM109990_RS08660	COG0697	spore germination
DSM109990_RS08665	COG0148	phosphopyruvate hydratase activity
DSM109990_RS08670	COG0456	acetyltransferase
DSM109990_RS08675	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DSM109990_RS08680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DSM109990_RS08695	COG0488	(ABC) transporter
DSM109990_RS08715	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DSM109990_RS08720	COG0416	fatty acid biosynthetic process
DSM109990_RS08725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM109990_RS08730	COG0776	regulation of translation
DSM109990_RS08745	COG0717	Belongs to the dCTP deaminase family
DSM109990_RS08755	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DSM109990_RS08760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DSM109990_RS08765	COG1472	Belongs to the glycosyl hydrolase 3 family
DSM109990_RS08775	COG0018	arginyl-trna synthetase
DSM109990_RS08785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DSM109990_RS08790	COG0316	Belongs to the HesB IscA family
DSM109990_RS08845	COG3328	transposase activity
DSM109990_RS08865	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
DSM109990_RS08870	COG0583	DNA-binding transcription factor activity
DSM109990_RS08875	COG0436	Aminotransferase
DSM109990_RS08880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM109990_RS08885	COG0583	DNA-binding transcription factor activity
DSM109990_RS08890	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DSM109990_RS08895	COG0732	type I restriction modification DNA specificity domain
DSM109990_RS08910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DSM109990_RS08920	COG0210	DNA helicase
DSM109990_RS08960	COG2814	Major facilitator Superfamily
DSM109990_RS08975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM109990_RS08980	COG0215	cysteine-tRNA ligase activity
DSM109990_RS09000	COG1595	DNA-templated transcription, initiation
DSM109990_RS09005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSM109990_RS09020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM109990_RS09040	COG0259	pyridoxamine-phosphate oxidase activity
DSM109990_RS09045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DSM109990_RS09050	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DSM109990_RS09055	COG0436	Aminotransferase
DSM109990_RS09065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DSM109990_RS09085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM109990_RS09090	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DSM109990_RS09100	COG0315	cyclic pyranopterin monophosphate synthase activity
DSM109990_RS09105	COG0303	'Molybdopterin
DSM109990_RS09110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DSM109990_RS09115	COG0658	competence protein
DSM109990_RS09115	COG2333	competence protein COMEC
DSM109990_RS09120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM109990_RS09125	COG0372	Belongs to the citrate synthase family
DSM109990_RS09135	COG1024	Enoyl-CoA hydratase
DSM109990_RS09140	COG3088	subunit of a heme lyase
DSM109990_RS09145	COG1138	Cytochrome C-type biogenesis protein
DSM109990_RS09160	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DSM109990_RS09165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DSM109990_RS09170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DSM109990_RS09190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM109990_RS09200	COG0542	response to heat
DSM109990_RS09235	COG0418	dihydroorotase activity
DSM109990_RS09240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DSM109990_RS09265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DSM109990_RS09285	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DSM109990_RS09295	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DSM109990_RS09300	COG2885	chlorophyll binding
DSM109990_RS09325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DSM109990_RS09325	COG3608	succinylglutamate desuccinylase aspartoacylase
DSM109990_RS09340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DSM109990_RS09345	COG0698	ribose 5-phosphate isomerase
DSM109990_RS09365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DSM109990_RS09370	COG2354	Protein conserved in bacteria
DSM109990_RS09390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DSM109990_RS09410	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DSM109990_RS09415	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS09435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DSM109990_RS09445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM109990_RS09455	COG2814	Major facilitator Superfamily
DSM109990_RS09460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DSM109990_RS09470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSM109990_RS09475	COG2833	Protein of unknown function (DUF455)
DSM109990_RS09480	COG0739	heme binding
DSM109990_RS09500	COG0126	phosphoglycerate kinase activity
DSM109990_RS09505	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DSM109990_RS09510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DSM109990_RS09520	COG0022	dehydrogenase e1 component
DSM109990_RS09520	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM109990_RS09525	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM109990_RS09605	COG4695	Portal protein
DSM109990_RS09615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DSM109990_RS09620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM109990_RS09630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DSM109990_RS09650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DSM109990_RS09655	COG0360	Binds together with S18 to 16S ribosomal RNA
DSM109990_RS09660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DSM109990_RS09665	COG0359	binds to the 23S rRNA
DSM109990_RS09675	COG0739	heme binding
DSM109990_RS09675	COG1196	nuclear chromosome segregation
DSM109990_RS09675	COG0741	lytic transglycosylase activity
DSM109990_RS09680	COG0737	Belongs to the 5'-nucleotidase family
DSM109990_RS09685	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSM109990_RS09695	COG3750	Belongs to the UPF0335 family
DSM109990_RS09710	COG5002	protein histidine kinase activity
DSM109990_RS09725	COG1396	sequence-specific DNA binding
DSM109990_RS09725	COG3800	Transcriptional regulator
DSM109990_RS09735	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM109990_RS09750	COG0410	ABC transporter
DSM109990_RS09760	COG0439	Biotin carboxylase
DSM109990_RS09765	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DSM109990_RS09790	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DSM109990_RS09795	COG0740	serine-type endopeptidase activity
DSM109990_RS09805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DSM109990_RS09810	COG0737	Belongs to the 5'-nucleotidase family
DSM109990_RS09815	COG3258	Cytochrome c
DSM109990_RS09840	COG0785	Cytochrome C biogenesis protein
DSM109990_RS09855	COG2391	methyltransferase activity
DSM109990_RS09870	COG1121	(ABC) transporter
DSM109990_RS09875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSM109990_RS09880	COG0251	oxidation-reduction process
DSM109990_RS09890	COG3483	tryptophan 2,3-dioxygenase activity
DSM109990_RS09900	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS09905	COG1024	Enoyl-CoA hydratase
DSM109990_RS09905	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM109990_RS09930	COG1846	Transcriptional regulator
DSM109990_RS09955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DSM109990_RS09975	COG4175	Glycine betaine
DSM109990_RS10000	COG1320	monovalent cation:proton antiporter activity
DSM109990_RS10005	COG2212	antiporter activity
DSM109990_RS10010	COG1863	multisubunit Na H antiporter MnhE subunit
DSM109990_RS10015	COG0651	ATP synthesis coupled electron transport
DSM109990_RS10020	COG1006	Multisubunit Na H antiporter MnhC subunit
DSM109990_RS10025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DSM109990_RS10025	COG2111	Na H antiporter
DSM109990_RS10030	COG0318	PFAM AMP-dependent synthetase and ligase
DSM109990_RS10045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM109990_RS10055	COG1573	uracil-dna glycosylase
DSM109990_RS10075	COG0587	DNA-directed DNA polymerase activity
DSM109990_RS10080	COG0351	phosphomethylpyrimidine kinase
DSM109990_RS10095	COG2022	thiamine diphosphate biosynthetic process
DSM109990_RS10105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSM109990_RS10110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM109990_RS10115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DSM109990_RS10120	COG1116	anion transmembrane transporter activity
DSM109990_RS10125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM109990_RS10140	COG1686	Belongs to the peptidase S11 family
DSM109990_RS10145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DSM109990_RS10155	COG0084	hydrolase, TatD family'
DSM109990_RS10160	COG1234	tRNA 3'-trailer cleavage
DSM109990_RS10170	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSM109990_RS10225	COG1295	ribonuclease BN
DSM109990_RS10230	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DSM109990_RS10260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSM109990_RS10265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DSM109990_RS10265	COG2010	Cytochrome c
DSM109990_RS10280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DSM109990_RS10305	COG0655	NAD(P)H dehydrogenase (quinone) activity
DSM109990_RS10310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM109990_RS10320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM109990_RS10325	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM109990_RS10330	COG4133	protoheme IX ABC transporter activity
DSM109990_RS10335	COG3737	Protein of unknown function (DUF498/DUF598)
DSM109990_RS10345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM109990_RS10350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM109990_RS10355	COG1862	Preprotein translocase
DSM109990_RS10360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DSM109990_RS10370	COG1160	GTP binding
DSM109990_RS10375	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM109990_RS10395	COG5265	(ABC) transporter
DSM109990_RS10410	COG2962	Rard protein
DSM109990_RS10435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM109990_RS10435	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM109990_RS10450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM109990_RS10455	COG4235	cytochrome complex assembly
DSM109990_RS10460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DSM109990_RS10475	COG0730	response to heat
DSM109990_RS10480	COG2814	Major facilitator Superfamily
DSM109990_RS10485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSM109990_RS10505	COG1175	transmembrane transport
DSM109990_RS10510	COG0395	ABC-type sugar transport system, permease component
DSM109990_RS10515	COG3842	ATPase activity
DSM109990_RS10525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DSM109990_RS10530	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM109990_RS10570	COG0628	permease
DSM109990_RS10595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM109990_RS10620	COG0729	surface antigen
DSM109990_RS10635	COG0321	lipoyl(octanoyl) transferase activity
DSM109990_RS10660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSM109990_RS10680	COG2873	o-acetylhomoserine
DSM109990_RS10705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSM109990_RS10705	COG0475	glutathione-regulated potassium exporter activity
DSM109990_RS10710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DSM109990_RS10715	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DSM109990_RS10720	COG1329	Transcriptional regulator
DSM109990_RS10725	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DSM109990_RS10750	COG2267	carboxylic ester hydrolase activity
DSM109990_RS10760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DSM109990_RS10760	COG1793	dna ligase
DSM109990_RS10770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DSM109990_RS10785	COG2186	Transcriptional regulator
DSM109990_RS10795	COG0564	pseudouridine synthase activity
DSM109990_RS10805	COG0483	inositol monophosphate 1-phosphatase activity
DSM109990_RS10810	COG2130	NADP-dependent
DSM109990_RS10815	COG0583	DNA-binding transcription factor activity
DSM109990_RS10865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM109990_RS10870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DSM109990_RS10875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM109990_RS10875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM109990_RS10900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM109990_RS10900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM109990_RS10905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DSM109990_RS10910	COG4221	oxidoreductase activity
DSM109990_RS10915	COG0432	Pfam Uncharacterised protein family UPF0047
DSM109990_RS10930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DSM109990_RS10935	COG0358	DNA primase activity
DSM109990_RS10950	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM109990_RS10950	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM109990_RS10960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM109990_RS10965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DSM109990_RS11030	COG0667	Aldo Keto reductase
DSM109990_RS11040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM109990_RS11060	COG1522	sequence-specific DNA binding
DSM109990_RS11070	COG1473	amidohydrolase
DSM109990_RS11095	COG0019	diaminopimelate decarboxylase activity
DSM109990_RS11105	COG0525	valine-tRNA ligase activity
DSM109990_RS11115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM109990_RS11120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSM109990_RS11125	COG1132	(ABC) transporter
DSM109990_RS11135	COG0354	folic acid binding
DSM109990_RS11145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DSM109990_RS11160	COG1492	cobalamin metabolic process
DSM109990_RS11170	COG1522	sequence-specific DNA binding
DSM109990_RS11185	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS11200	COG0131	Imidazoleglycerol-phosphate dehydratase
DSM109990_RS11205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DSM109990_RS11215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DSM109990_RS11220	COG0107	imidazoleglycerol-phosphate synthase activity
DSM109990_RS11225	COG0140	phosphoribosyl-ATP diphosphatase activity
DSM109990_RS11230	COG1832	CoA-binding protein
DSM109990_RS11235	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS11240	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS11245	COG1946	Acyl-CoA thioesterase
DSM109990_RS11310	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DSM109990_RS11315	COG1530	ribonuclease E activity
DSM109990_RS11320	COG0424	maF-like protein
DSM109990_RS11325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DSM109990_RS11340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DSM109990_RS11345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSM109990_RS11350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DSM109990_RS11355	COG1183	phosphatidylcholine synthase activity
DSM109990_RS11365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DSM109990_RS11380	COG1216	Glycosyl transferase, family 2
DSM109990_RS11390	COG0438	transferase activity, transferring glycosyl groups
DSM109990_RS11400	COG3768	UPF0283 membrane protein
DSM109990_RS11410	COG3106	COG3106 Predicted ATPase
DSM109990_RS11415	COG0101	tRNA pseudouridine synthase activity
DSM109990_RS11420	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DSM109990_RS11430	COG0306	phosphate transporter
DSM109990_RS11445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSM109990_RS11495	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DSM109990_RS11500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSM109990_RS11505	COG0135	phosphoribosylanthranilate isomerase activity
DSM109990_RS11515	COG0776	regulation of translation
DSM109990_RS11520	COG0539	negative regulation of cytoplasmic translation
DSM109990_RS11525	COG2205	protein histidine kinase activity
DSM109990_RS11525	COG3437	response regulator, receiver
DSM109990_RS11525	COG3850	Histidine kinase
DSM109990_RS11525	COG4999	Histidine kinase
DSM109990_RS11530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DSM109990_RS11535	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DSM109990_RS11545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DSM109990_RS11555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DSM109990_RS11560	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DSM109990_RS11565	COG1253	flavin adenine dinucleotide binding
DSM109990_RS11570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DSM109990_RS11575	COG1702	phosphate starvation-inducible protein PhoH
DSM109990_RS11585	COG2885	chlorophyll binding
DSM109990_RS11595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM109990_RS11610	COG1183	phosphatidylcholine synthase activity
DSM109990_RS11625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM109990_RS11630	COG0702	epimerase
DSM109990_RS11635	COG1012	belongs to the aldehyde dehydrogenase family
DSM109990_RS11640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM109990_RS11645	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DSM109990_RS11655	COG1047	Peptidyl-prolyl cis-trans
DSM109990_RS11675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM109990_RS11700	COG0837	glucose binding
DSM109990_RS11715	COG1228	amidohydrolase
DSM109990_RS11720	COG2986	histidine ammonia-lyase
DSM109990_RS11745	COG1238	metal cluster binding
DSM109990_RS11775	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DSM109990_RS11780	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DSM109990_RS11785	COG3639	organic phosphonate transmembrane transporter activity
DSM109990_RS11790	COG3639	organic phosphonate transmembrane transporter activity
DSM109990_RS11800	COG2188	Transcriptional regulator
DSM109990_RS11805	COG3624	Phosphonate C-P lyase system protein PhnG
DSM109990_RS11810	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
DSM109990_RS11815	COG3626	phosphonate metabolism
DSM109990_RS11820	COG3627	carbon phosphorus lyase activity
DSM109990_RS11825	COG4107	phosphonate C-P lyase system protein PhnK
DSM109990_RS11830	COG4778	phosphonate C-P lyase system protein PhnL
DSM109990_RS11845	COG3454	Phosphonate metabolism
DSM109990_RS11865	COG1177	transmembrane transport
DSM109990_RS11870	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM109990_RS11875	COG3842	ATPase activity
DSM109990_RS11880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DSM109990_RS11885	COG0154	amidase activity
DSM109990_RS11950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DSM109990_RS11955	COG0463	Glycosyl transferase, family 2
DSM109990_RS11970	COG0586	Pfam SNARE associated Golgi protein
DSM109990_RS11975	COG1230	cation diffusion facilitator family transporter
DSM109990_RS12000	COG2259	Doxx family
DSM109990_RS12050	COG3547	Transposase (IS116 IS110 IS902 family)
DSM109990_RS12070	COG0410	ABC transporter
DSM109990_RS12080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM109990_RS12085	COG1522	sequence-specific DNA binding
DSM109990_RS12095	COG3386	PFAM SMP-30 Gluconolaconase
DSM109990_RS12100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM109990_RS12170	COG0012	GTP binding
DSM109990_RS12180	COG0159	tryptophan synthase activity
DSM109990_RS12195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DSM109990_RS12200	COG0193	aminoacyl-tRNA hydrolase activity
DSM109990_RS12235	COG0133	tryptophan synthase activity
DSM109990_RS12245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM109990_RS12255	COG0583	DNA-binding transcription factor activity
DSM109990_RS12295	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DSM109990_RS12300	COG1214	PFAM Peptidase M22, glycoprotease
DSM109990_RS12310	COG1744	ABC transporter substrate-binding protein PnrA-like
DSM109990_RS12315	COG3845	ABC transporter
DSM109990_RS12320	COG4603	Belongs to the binding-protein-dependent transport system permease family
DSM109990_RS12325	COG1079	Belongs to the binding-protein-dependent transport system permease family
DSM109990_RS12330	COG0730	response to heat
DSM109990_RS12345	COG2197	response regulator
DSM109990_RS12350	COG0604	alcohol dehydrogenase
DSM109990_RS12355	COG2937	Belongs to the GPAT DAPAT family
DSM109990_RS12360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM109990_RS12360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM109990_RS12370	COG0813	purine-nucleoside phosphorylase activity
DSM109990_RS12405	COG0039	L-malate dehydrogenase activity
DSM109990_RS12420	COG2301	Belongs to the HpcH HpaI aldolase family
DSM109990_RS12435	COG2030	dehydratase
DSM109990_RS12440	COG0045	succinate-CoA ligase (ADP-forming) activity
DSM109990_RS12470	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM109990_RS12505	COG2884	Cell division ATP-binding protein ftsE
DSM109990_RS12520	COG0019	diaminopimelate decarboxylase activity
DSM109990_RS12540	COG0165	Argininosuccinate lyase
DSM109990_RS12545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM109990_RS12565	COG0402	S-adenosylhomocysteine deaminase activity
DSM109990_RS12570	COG1079	Belongs to the binding-protein-dependent transport system permease family
DSM109990_RS12575	COG4603	Belongs to the binding-protein-dependent transport system permease family
DSM109990_RS12580	COG3845	ABC transporter
DSM109990_RS12590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM109990_RS12610	COG0811	peptide transport
DSM109990_RS12625	COG0640	Transcriptional regulator
DSM109990_RS12640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM109990_RS12640	COG3453	Protein conserved in bacteria
DSM109990_RS12655	COG2951	lytic endotransglycosylase activity
DSM109990_RS12665	COG1815	bacterial-type flagellum-dependent cell motility
DSM109990_RS12670	COG1558	bacterial-type flagellum-dependent cell motility
DSM109990_RS12675	COG1677	Flagellar hook-basal body complex protein FliE
DSM109990_RS12680	COG1987	bacterial-type flagellum assembly
DSM109990_RS12690	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DSM109990_RS12700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DSM109990_RS12725	COG1766	The M ring may be actively involved in energy transduction
DSM109990_RS12735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM109990_RS12740	COG1338	Plays a role in the flagellum-specific transport system
DSM109990_RS12745	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM109990_RS12755	COG5443	negative regulation of bacterial-type flagellum assembly
DSM109990_RS12760	COG5442	Flagellar protein FlaF
DSM109990_RS12765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSM109990_RS12780	COG1706	bacterial-type flagellum-dependent cell motility
DSM109990_RS12795	COG1749	Flagellar hook protein flgE
DSM109990_RS12805	COG4786	Flagellar basal body rod
DSM109990_RS12810	COG4786	Flagellar basal body rod
DSM109990_RS12820	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DSM109990_RS12845	COG1360	Flagellar Motor Protein
DSM109990_RS12860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DSM109990_RS12895	COG0174	glutamine synthetase
DSM109990_RS12900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM109990_RS12910	COG1174	glycine betaine transport
DSM109990_RS12915	COG1125	glycine betaine transport
DSM109990_RS12920	COG1174	glycine betaine transport
DSM109990_RS12925	COG1732	Glycine betaine
DSM109990_RS12960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM109990_RS12970	COG0604	alcohol dehydrogenase
DSM109990_RS12970	COG3321	synthase
DSM109990_RS12975	COG0583	DNA-binding transcription factor activity
DSM109990_RS12985	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS12990	COG5002	protein histidine kinase activity
DSM109990_RS13025	COG3842	ATPase activity
DSM109990_RS13030	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM109990_RS13035	COG1177	transmembrane transport
DSM109990_RS13045	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DSM109990_RS13060	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS13070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS13075	COG0601	transmembrane transport
DSM109990_RS13085	COG1802	Transcriptional regulator
DSM109990_RS13095	COG0028	Belongs to the TPP enzyme family
DSM109990_RS13100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM109990_RS13115	COG4172	Belongs to the ABC transporter superfamily
DSM109990_RS13120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS13125	COG0601	transmembrane transport
DSM109990_RS13130	COG0747	negative chemotaxis
DSM109990_RS13135	COG1162	GTPase activity
DSM109990_RS13140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM109990_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS13150	COG2084	Dehydrogenase
DSM109990_RS13155	COG0129	dihydroxy-acid dehydratase activity
DSM109990_RS13170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM109990_RS13180	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
DSM109990_RS13185	COG0410	ABC transporter
DSM109990_RS13190	COG1137	ATPase activity
DSM109990_RS13230	COG2207	Transcriptional regulator
DSM109990_RS13235	COG2205	protein histidine kinase activity
DSM109990_RS13255	COG2828	Protein conserved in bacteria
DSM109990_RS13270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM109990_RS13280	COG1802	Transcriptional regulator
DSM109990_RS13300	COG3781	membrane
DSM109990_RS13305	COG0583	DNA-binding transcription factor activity
DSM109990_RS13325	COG0667	Aldo Keto reductase
DSM109990_RS13350	COG1231	oxidoreductase activity
DSM109990_RS13405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM109990_RS13420	COG2358	TRAP transporter, solute receptor (TAXI family
DSM109990_RS13430	COG2030	dehydratase
DSM109990_RS13435	COG1414	Transcriptional regulator
DSM109990_RS13455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DSM109990_RS13460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM109990_RS13475	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS13480	COG0583	DNA-binding transcription factor activity
DSM109990_RS13515	COG0683	leucine binding
DSM109990_RS13520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM109990_RS13565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM109990_RS13575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DSM109990_RS13580	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DSM109990_RS13585	COG0124	histidyl-tRNA synthetase
DSM109990_RS13610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM109990_RS13620	COG3845	ABC transporter
DSM109990_RS13625	COG4603	Belongs to the binding-protein-dependent transport system permease family
DSM109990_RS13630	COG1079	Belongs to the binding-protein-dependent transport system permease family
DSM109990_RS13655	COG3757	hydrolase, family 25
DSM109990_RS13675	COG0277	FAD linked oxidase domain protein
DSM109990_RS13690	COG0604	alcohol dehydrogenase
DSM109990_RS13715	COG4607	ABC-type enterochelin transport system periplasmic component
DSM109990_RS13720	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM109990_RS13725	COG4605	iron ion homeostasis
DSM109990_RS13730	COG4604	ABC transporter, ATP-binding protein
DSM109990_RS13760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM109990_RS13790	COG0318	PFAM AMP-dependent synthetase and ligase
DSM109990_RS13795	COG1024	Enoyl-CoA hydratase
DSM109990_RS13805	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS13810	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS13815	COG0183	Belongs to the thiolase family
DSM109990_RS13820	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM109990_RS13820	COG1024	Enoyl-CoA hydratase
DSM109990_RS13845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DSM109990_RS13850	COG3246	L-lysine catabolic process to acetate
DSM109990_RS13855	COG0481	GTPase activity
DSM109990_RS13870	COG5328	Belongs to the UPF0262 family
DSM109990_RS13875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DSM109990_RS13890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DSM109990_RS13905	COG2032	superoxide dismutase activity
DSM109990_RS13990	COG0625	glutathione transferase activity
DSM109990_RS14005	COG3328	transposase activity
DSM109990_RS14015	COG5507	3-demethylubiquinone-9 3-methyltransferase
DSM109990_RS14045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DSM109990_RS14055	COG3547	Transposase (IS116 IS110 IS902 family)
DSM109990_RS14065	COG3328	transposase activity
DSM109990_RS14095	COG0784	Response regulator, receiver
DSM109990_RS14095	COG5002	protein histidine kinase activity
DSM109990_RS14095	COG2198	Histidine kinase
DSM109990_RS14105	COG2197	response regulator
DSM109990_RS14115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DSM109990_RS14150	COG1609	Transcriptional regulator
DSM109990_RS14155	COG0800	Aldolase
DSM109990_RS14160	COG0129	dihydroxy-acid dehydratase activity
DSM109990_RS14165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DSM109990_RS14195	COG0697	spore germination
DSM109990_RS14210	COG0154	amidase activity
DSM109990_RS14225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM109990_RS14245	COG0556	nucleotide-excision repair
DSM109990_RS14280	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DSM109990_RS14300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DSM109990_RS14305	COG1115	amino acid carrier protein
DSM109990_RS14315	COG0488	(ABC) transporter
DSM109990_RS14325	COG1278	Cold shock
DSM109990_RS14330	COG1376	ErfK ybiS ycfS ynhG family protein
DSM109990_RS14340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM109990_RS14345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM109990_RS14365	COG1309	transcriptional regulator
DSM109990_RS14380	COG0493	'glutamate synthase
DSM109990_RS14385	COG1278	Cold shock
DSM109990_RS14395	COG4181	ATPase activity
DSM109990_RS14400	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DSM109990_RS14405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM109990_RS14405	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM109990_RS14410	COG0509	glycine decarboxylation via glycine cleavage system
DSM109990_RS14415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM109990_RS14425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM109990_RS14450	COG3046	protein related to deoxyribodipyrimidine photolyase
DSM109990_RS14460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM109990_RS14485	COG0768	penicillin binding
DSM109990_RS14490	COG0772	Belongs to the SEDS family
DSM109990_RS14495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM109990_RS14500	COG0339	signal peptide processing
DSM109990_RS14505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSM109990_RS14510	COG0756	dUTP diphosphatase activity
DSM109990_RS14515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DSM109990_RS14540	COG0606	chelatase, subunit chli
DSM109990_RS14550	COG0189	ligase activity
DSM109990_RS14555	COG0792	nuclease activity
DSM109990_RS14560	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DSM109990_RS14570	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DSM109990_RS14590	COG0180	Tryptophanyl-tRNA synthetase
DSM109990_RS14595	COG2514	catechol 2,3-dioxygenase activity
DSM109990_RS14605	COG0778	Nitroreductase
DSM109990_RS14620	COG0346	lactoylglutathione lyase activity
DSM109990_RS14625	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS14655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DSM109990_RS14660	COG0438	transferase activity, transferring glycosyl groups
DSM109990_RS14720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DSM109990_RS14735	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSM109990_RS14745	COG0300	oxidoreductase activity
DSM109990_RS14755	COG2096	Adenosyltransferase
DSM109990_RS14775	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM109990_RS14785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM109990_RS14795	COG1660	Displays ATPase and GTPase activities
DSM109990_RS14805	COG2205	protein histidine kinase activity
DSM109990_RS14810	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS14815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DSM109990_RS14820	COG0583	DNA-binding transcription factor activity
DSM109990_RS14825	COG1396	sequence-specific DNA binding
DSM109990_RS14840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DSM109990_RS14850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM109990_RS14855	COG0356	it plays a direct role in the translocation of protons across the membrane
DSM109990_RS14880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DSM109990_RS14885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DSM109990_RS14895	COG0228	four-way junction DNA binding
DSM109990_RS14900	COG0778	Nitroreductase
DSM109990_RS14910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DSM109990_RS14920	COG0336	Belongs to the RNA methyltransferase TrmD family
DSM109990_RS14930	COG0335	large ribosomal subunit rRNA binding
DSM109990_RS14935	COG0254	rRNA binding
DSM109990_RS14945	COG0489	protein tyrosine kinase activity
DSM109990_RS14945	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM109990_RS14960	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DSM109990_RS14965	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM109990_RS14990	COG0747	negative chemotaxis
DSM109990_RS15000	COG0673	inositol 2-dehydrogenase activity
DSM109990_RS15015	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS15025	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DSM109990_RS15035	COG1686	Belongs to the peptidase S11 family
DSM109990_RS15040	COG4172	Belongs to the ABC transporter superfamily
DSM109990_RS15045	COG4239	(ABC) transporter, permease
DSM109990_RS15050	COG4174	ABC transporter (Permease)
DSM109990_RS15055	COG4166	transmembrane transport
DSM109990_RS15060	COG2267	carboxylic ester hydrolase activity
DSM109990_RS15070	COG0077	Prephenate dehydratase
DSM109990_RS15080	COG2816	NAD+ diphosphatase activity
DSM109990_RS15085	COG0737	Belongs to the 5'-nucleotidase family
DSM109990_RS15095	COG2321	neutral zinc metallopeptidase
DSM109990_RS15105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DSM109990_RS15110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DSM109990_RS15115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DSM109990_RS15140	COG0604	alcohol dehydrogenase
DSM109990_RS15140	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS15140	COG3321	synthase
DSM109990_RS15150	COG0183	Belongs to the thiolase family
DSM109990_RS15155	COG1268	BioY protein
DSM109990_RS15160	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DSM109990_RS15165	COG1122	ATPase activity
DSM109990_RS15175	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DSM109990_RS15185	COG0686	Belongs to the AlaDH PNT family
DSM109990_RS15190	COG1970	mechanosensitive ion channel activity
DSM109990_RS15205	COG0072	phenylalanine-tRNA ligase activity
DSM109990_RS15205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM109990_RS15215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DSM109990_RS15235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DSM109990_RS15240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DSM109990_RS15250	COG0469	pyruvate kinase activity
DSM109990_RS15280	COG4948	Mandelate Racemase Muconate Lactonizing
DSM109990_RS15295	COG0825	malonyl-CoA metabolic process
DSM109990_RS15315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DSM109990_RS15315	COG0512	Glutamine amidotransferase of anthranilate synthase
DSM109990_RS15350	COG1381	Involved in DNA repair and RecF pathway recombination
DSM109990_RS15360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DSM109990_RS15365	COG0571	ribonuclease III activity
DSM109990_RS15370	COG0681	Belongs to the peptidase S26 family
DSM109990_RS15375	COG0736	holo-[acyl-carrier-protein] synthase activity
DSM109990_RS15385	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DSM109990_RS15395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSM109990_RS15400	COG1758	RNA polymerase activity
DSM109990_RS15405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DSM109990_RS15420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DSM109990_RS15425	COG0328	RNA-DNA hybrid ribonuclease activity
DSM109990_RS15430	COG2860	membrane
DSM109990_RS15435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM109990_RS15440	COG0242	peptide deformylase activity
DSM109990_RS15445	COG0242	peptide deformylase activity
DSM109990_RS15450	COG0242	peptide deformylase activity
DSM109990_RS15455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DSM109990_RS15465	COG0435	Glutathione S-transferase
DSM109990_RS15475	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DSM109990_RS15490	COG0251	oxidation-reduction process
DSM109990_RS15495	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DSM109990_RS15500	COG0709	Synthesizes selenophosphate from selenide and ATP
DSM109990_RS15510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM109990_RS15520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DSM109990_RS15525	COG2971	BadF BadG BcrA BcrD
DSM109990_RS15530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM109990_RS15535	COG0243	molybdopterin cofactor binding
DSM109990_RS15540	COG0437	4 iron, 4 sulfur cluster binding
DSM109990_RS15550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM109990_RS15555	COG0741	lytic transglycosylase activity
DSM109990_RS15565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM109990_RS15565	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DSM109990_RS15575	COG2885	chlorophyll binding
DSM109990_RS15580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSM109990_RS15585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DSM109990_RS15590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM109990_RS15605	COG1051	belongs to the nudix hydrolase family
DSM109990_RS15610	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM109990_RS15610	COG1902	pentaerythritol trinitrate reductase activity
DSM109990_RS15620	COG0583	DNA-binding transcription factor activity
DSM109990_RS15625	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DSM109990_RS15640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DSM109990_RS15650	COG0129	dihydroxy-acid dehydratase activity
DSM109990_RS15675	COG0793	Belongs to the peptidase S41A family
DSM109990_RS15685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DSM109990_RS15695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM109990_RS15695	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM109990_RS15710	COG3622	Belongs to the hyi family
DSM109990_RS15720	COG0714	Associated with various cellular activities
DSM109990_RS15750	COG3022	response to hydroperoxide
DSM109990_RS15755	COG0514	ATP-dependent DNA helicase (RecQ)
DSM109990_RS15775	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
DSM109990_RS15810	COG1797	cobyrinic acid a,c-diamide synthase activity
DSM109990_RS15815	COG2875	Belongs to the precorrin methyltransferase family
DSM109990_RS15830	COG2099	Precorrin-6x reductase
DSM109990_RS15885	COG3920	Histidine kinase
DSM109990_RS15890	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DSM109990_RS15895	COG1335	isochorismatase
DSM109990_RS15900	COG1054	Belongs to the UPF0176 family
DSM109990_RS15905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM109990_RS15910	COG1177	transmembrane transport
DSM109990_RS15915	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM109990_RS15920	COG3842	ATPase activity
DSM109990_RS15930	COG1802	Transcriptional regulator
DSM109990_RS15940	COG2951	lytic endotransglycosylase activity
DSM109990_RS15945	COG0557	exoribonuclease II activity
DSM109990_RS15955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM109990_RS15970	COG2171	N-acyltransferase activity
DSM109990_RS15990	COG0784	Response regulator, receiver
DSM109990_RS15990	COG2198	Histidine kinase
DSM109990_RS15990	COG2205	protein histidine kinase activity
DSM109990_RS15995	COG5002	protein histidine kinase activity
DSM109990_RS16010	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS16015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM109990_RS16020	COG1012	belongs to the aldehyde dehydrogenase family
DSM109990_RS16025	COG1522	sequence-specific DNA binding
DSM109990_RS16030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM109990_RS16035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM109990_RS16040	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM109990_RS16045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM109990_RS16050	COG0589	response to stress
DSM109990_RS16060	COG0006	proline dipeptidase activity
DSM109990_RS16065	COG3608	succinylglutamate desuccinylase aspartoacylase
DSM109990_RS16070	COG4608	Belongs to the ABC transporter superfamily
DSM109990_RS16075	COG0444	Belongs to the ABC transporter superfamily
DSM109990_RS16080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS16085	COG0601	transmembrane transport
DSM109990_RS16090	COG0006	proline dipeptidase activity
DSM109990_RS16095	COG0747	negative chemotaxis
DSM109990_RS16115	COG0444	Belongs to the ABC transporter superfamily
DSM109990_RS16120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS16125	COG0601	transmembrane transport
DSM109990_RS16140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DSM109990_RS16150	COG0456	acetyltransferase
DSM109990_RS16155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DSM109990_RS16160	COG1917	Cupin 2, conserved barrel domain protein
DSM109990_RS16165	COG0527	aspartate kinase activity
DSM109990_RS16180	COG0560	Phosphoserine phosphatase
DSM109990_RS16185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DSM109990_RS16190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM109990_RS16195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DSM109990_RS16200	COG1063	alcohol dehydrogenase
DSM109990_RS16205	COG0156	8-amino-7-oxononanoate synthase activity
DSM109990_RS16210	COG1396	sequence-specific DNA binding
DSM109990_RS16215	COG0183	Belongs to the thiolase family
DSM109990_RS16225	COG2226	methyltransferase
DSM109990_RS16230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DSM109990_RS16235	COG1024	Enoyl-CoA hydratase
DSM109990_RS16240	COG0268	Binds directly to 16S ribosomal RNA
DSM109990_RS16250	COG1192	Involved in chromosome partitioning
DSM109990_RS16290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DSM109990_RS16335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM109990_RS16345	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM109990_RS16350	COG4605	iron ion homeostasis
DSM109990_RS16355	COG4604	ABC transporter, ATP-binding protein
DSM109990_RS16360	COG4771	TonB-dependent receptor
DSM109990_RS16425	COG3181	Tripartite tricarboxylate transporter family receptor
DSM109990_RS16440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM109990_RS16450	COG2814	Major facilitator Superfamily
DSM109990_RS16465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSM109990_RS16470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DSM109990_RS16470	COG2010	Cytochrome c
DSM109990_RS16570	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS16590	COG2337	Toxic component of a toxin-antitoxin (TA) module
DSM109990_RS16605	COG2161	toxin-antitoxin pair type II binding
DSM109990_RS16610	COG4115	mRNA cleavage
DSM109990_RS16615	COG0174	glutamine synthetase
DSM109990_RS16630	COG3550	peptidyl-serine autophosphorylation
DSM109990_RS16635	COG3620	sequence-specific DNA binding
DSM109990_RS16660	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM109990_RS16675	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS16705	COG3608	succinylglutamate desuccinylase aspartoacylase
DSM109990_RS16720	COG0251	oxidation-reduction process
DSM109990_RS16770	COG0662	Cupin 2, conserved barrel domain protein
DSM109990_RS16770	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DSM109990_RS16785	COG0175	sulfate reduction
DSM109990_RS16805	COG1132	(ABC) transporter
DSM109990_RS16825	COG4106	trans-aconitate 2-methyltransferase activity
DSM109990_RS16850	COG1012	belongs to the aldehyde dehydrogenase family
DSM109990_RS16900	COG3321	synthase
DSM109990_RS16900	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS16900	COG0604	alcohol dehydrogenase
DSM109990_RS16915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DSM109990_RS16925	COG3328	transposase activity
DSM109990_RS16955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM109990_RS17030	COG4964	Belongs to the GSP D family
DSM109990_RS17080	COG3436	PFAM IS66 Orf2 family protein
DSM109990_RS17085	COG4372	Transposase
DSM109990_RS17090	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS17105	COG0776	regulation of translation
DSM109990_RS17115	COG3328	transposase activity
DSM109990_RS17125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DSM109990_RS17135	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DSM109990_RS17140	COG0500	methyltransferase
DSM109990_RS17150	COG0024	Methionine aminopeptidase
DSM109990_RS17175	COG2084	Dehydrogenase
DSM109990_RS17180	COG0129	dihydroxy-acid dehydratase activity
DSM109990_RS17185	COG3622	Belongs to the hyi family
DSM109990_RS17215	COG2205	protein histidine kinase activity
DSM109990_RS17215	COG0784	Response regulator, receiver
DSM109990_RS17220	COG3850	Histidine kinase
DSM109990_RS17220	COG4999	Histidine kinase
DSM109990_RS17220	COG2205	protein histidine kinase activity
DSM109990_RS17220	COG3437	response regulator, receiver
DSM109990_RS17225	COG3547	Transposase (IS116 IS110 IS902 family)
DSM109990_RS17230	COG1484	DNA-dependent DNA replication
DSM109990_RS17250	COG0745	RESPONSE REGULATOR receiver
DSM109990_RS17265	COG0784	Response regulator, receiver
DSM109990_RS17265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM109990_RS17265	COG2198	Histidine kinase
DSM109990_RS17265	COG2205	protein histidine kinase activity
DSM109990_RS17290	COG3609	addiction module antidote protein, CC2985 family
DSM109990_RS17315	COG0454	-acetyltransferase
DSM109990_RS17315	COG0456	acetyltransferase
DSM109990_RS17325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM109990_RS17340	COG3609	addiction module antidote protein, CC2985 family
DSM109990_RS17355	COG3547	Transposase (IS116 IS110 IS902 family)
DSM109990_RS17360	COG3547	Transposase (IS116 IS110 IS902 family)
DSM109990_RS17365	COG1484	DNA-dependent DNA replication
DSM109990_RS17370	COG4584	PFAM Integrase catalytic
DSM109990_RS17390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM109990_RS17395	COG2274	protein secretion by the type I secretion system
DSM109990_RS17445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM109990_RS17480	COG1192	Involved in chromosome partitioning
DSM109990_RS17490	COG3547	Transposase (IS116 IS110 IS902 family)
DSM109990_RS17495	COG1192	Involved in chromosome partitioning
DSM109990_RS17500	COG1475	DNA binding
DSM109990_RS17510	COG3852	Histidine kinase
DSM109990_RS17515	COG1363	Peptidase, m42
DSM109990_RS17530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM109990_RS17555	COG1021	2,3-dihydroxybenzoate-AMP ligase
DSM109990_RS17565	COG4221	oxidoreductase activity
DSM109990_RS17570	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DSM109990_RS17575	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS17580	COG2084	Dehydrogenase
DSM109990_RS17585	COG1012	belongs to the aldehyde dehydrogenase family
DSM109990_RS17600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM109990_RS17615	COG3639	organic phosphonate transmembrane transporter activity
DSM109990_RS17630	COG2188	Transcriptional regulator
DSM109990_RS17635	COG0730	response to heat
DSM109990_RS17645	COG0405	Gamma-glutamyltransferase
DSM109990_RS17650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS17655	COG0601	transmembrane transport
DSM109990_RS17660	COG0747	negative chemotaxis
DSM109990_RS17665	COG4608	Belongs to the ABC transporter superfamily
DSM109990_RS17680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM109990_RS17685	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DSM109990_RS17705	COG1280	lysine exporter protein (LysE YggA)
DSM109990_RS17730	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DSM109990_RS17735	COG1349	DNA-binding transcription factor activity
DSM109990_RS17745	COG3842	ATPase activity
DSM109990_RS17760	COG0395	ABC-type sugar transport system, permease component
DSM109990_RS17775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DSM109990_RS17780	COG1454	alcohol dehydrogenase
DSM109990_RS17795	COG4608	Belongs to the ABC transporter superfamily
DSM109990_RS17800	COG0444	Belongs to the ABC transporter superfamily
DSM109990_RS17805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS17810	COG0601	transmembrane transport
DSM109990_RS17815	COG0747	negative chemotaxis
DSM109990_RS17820	COG1414	Transcriptional regulator
DSM109990_RS17825	COG0753	catalase activity
DSM109990_RS17840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DSM109990_RS17850	COG0625	glutathione transferase activity
DSM109990_RS17865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM109990_RS17870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM109990_RS17875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSM109990_RS17885	COG2943	transferase activity, transferring hexosyl groups
DSM109990_RS17895	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DSM109990_RS17900	COG3128	pkhd-type hydroxylase
DSM109990_RS17905	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DSM109990_RS17915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM109990_RS17920	COG0765	amino acid transport
DSM109990_RS17935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM109990_RS17940	COG3938	Belongs to the proline racemase family
DSM109990_RS17950	COG3938	Belongs to the proline racemase family
DSM109990_RS17965	COG4533	DNA binding
DSM109990_RS17975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS17980	COG0444	Belongs to the ABC transporter superfamily
DSM109990_RS17990	COG4166	transmembrane transport
DSM109990_RS17995	COG0601	transmembrane transport
DSM109990_RS18000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS18030	COG0673	inositol 2-dehydrogenase activity
DSM109990_RS18035	COG1129	ABC transporter
DSM109990_RS18040	COG1172	Belongs to the binding-protein-dependent transport system permease family
DSM109990_RS18050	COG1070	Carbohydrate kinase
DSM109990_RS18070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DSM109990_RS18075	COG4608	Belongs to the ABC transporter superfamily
DSM109990_RS18080	COG0444	Belongs to the ABC transporter superfamily
DSM109990_RS18085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS18090	COG0601	transmembrane transport
DSM109990_RS18110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM109990_RS18115	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DSM109990_RS18120	COG2080	2 iron, 2 sulfur cluster binding
DSM109990_RS18125	COG2826	transposase and inactivated derivatives, IS30 family
DSM109990_RS18140	COG0405	Gamma-glutamyltransferase
DSM109990_RS18145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM109990_RS18170	COG0601	transmembrane transport
DSM109990_RS18175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS18185	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DSM109990_RS18195	COG0438	transferase activity, transferring glycosyl groups
DSM109990_RS18200	COG0438	transferase activity, transferring glycosyl groups
DSM109990_RS18220	COG2274	protein secretion by the type I secretion system
DSM109990_RS18225	COG0754	glutathionylspermidine amidase activity
DSM109990_RS18230	COG5463	Belongs to the UPF0441 family
DSM109990_RS18235	COG3781	membrane
DSM109990_RS18245	COG3246	L-lysine catabolic process to acetate
DSM109990_RS18250	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM109990_RS18250	COG1024	Enoyl-CoA hydratase
DSM109990_RS18255	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS18260	COG0583	DNA-binding transcription factor activity
DSM109990_RS18265	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DSM109990_RS18275	COG2721	sulfolactate sulfo-lyase activity
DSM109990_RS18285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DSM109990_RS18290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM109990_RS18310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM109990_RS18325	COG1691	(AIR) carboxylase
DSM109990_RS18335	COG2186	Transcriptional regulator
DSM109990_RS18340	COG2358	TRAP transporter, solute receptor (TAXI family
DSM109990_RS18345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM109990_RS18345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM109990_RS18350	COG0028	Belongs to the TPP enzyme family
DSM109990_RS18355	COG0277	FAD linked oxidase domain protein
DSM109990_RS18360	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS18365	COG1309	transcriptional regulator
DSM109990_RS18375	COG0829	nickel cation binding
DSM109990_RS18380	COG0831	urea catabolic process
DSM109990_RS18390	COG0832	Belongs to the urease beta subunit family
DSM109990_RS18395	COG0804	urea catabolic process
DSM109990_RS18400	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DSM109990_RS18405	COG0830	nickel cation binding
DSM109990_RS18410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DSM109990_RS18425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM109990_RS18455	COG1522	sequence-specific DNA binding
DSM109990_RS18465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DSM109990_RS18485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM109990_RS18505	COG1126	abc transporter atp-binding protein
DSM109990_RS18520	COG2204	response regulator
DSM109990_RS18530	COG0437	4 iron, 4 sulfur cluster binding
DSM109990_RS18535	COG3383	formate dehydrogenase (NAD+) activity
DSM109990_RS18535	COG0243	molybdopterin cofactor binding
DSM109990_RS18570	COG0489	protein tyrosine kinase activity
DSM109990_RS18600	COG1192	Involved in chromosome partitioning
DSM109990_RS18610	COG0640	Transcriptional regulator
DSM109990_RS18620	COG3609	addiction module antidote protein, CC2985 family
DSM109990_RS18640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DSM109990_RS18650	COG3328	transposase activity
DSM109990_RS18675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM109990_RS18680	COG0251	oxidation-reduction process
DSM109990_RS18690	COG0747	negative chemotaxis
DSM109990_RS18695	COG0601	transmembrane transport
DSM109990_RS18700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM109990_RS18720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM109990_RS18725	COG0583	DNA-binding transcription factor activity
DSM109990_RS18735	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM109990_RS18735	COG1902	pentaerythritol trinitrate reductase activity
DSM109990_RS18745	COG0765	amino acid transport
DSM109990_RS18750	COG0765	amino acid transport
DSM109990_RS18775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM109990_RS18790	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
DSM109990_RS18800	COG1802	Transcriptional regulator
DSM109990_RS18850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DSM109990_RS18855	COG1802	Transcriptional regulator
DSM109990_RS18860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM109990_RS18875	COG2826	transposase and inactivated derivatives, IS30 family
DSM109990_RS18890	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS18895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM109990_RS18905	COG1172	Belongs to the binding-protein-dependent transport system permease family
DSM109990_RS18910	COG1129	ABC transporter
DSM109990_RS18920	COG0235	Class ii aldolase
DSM109990_RS18925	COG1028	Short-chain dehydrogenase reductase Sdr
DSM109990_RS18930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM109990_RS18955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM109990_RS18960	COG2031	fatty acid transporter
DSM109990_RS18965	COG1309	transcriptional regulator
DSM109990_RS18980	COG1846	Transcriptional regulator
DSM109990_RS19005	COG0758	DNA mediated transformation
DSM109990_RS19030	COG3328	transposase activity
DSM109990_RS19040	COG3012	SEC-C Motif Domain Protein
DSM109990_RS19070	COG1794	racemase activity, acting on amino acids and derivatives
DSM109990_RS19080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM109990_RS19095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DSM109990_RS19140	COG0411	ABC transporter
DSM109990_RS19175	COG1414	Transcriptional regulator
DSM109990_RS19185	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DSM109990_RS19190	COG0183	Belongs to the thiolase family
DSM109990_RS19215	COG4145	pantothenate transmembrane transporter activity
DSM109990_RS19230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DSM109990_RS19235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM109990_RS19240	COG3246	L-lysine catabolic process to acetate
DSM109990_RS19245	COG3485	protocatechuate 3,4-dioxygenase
DSM109990_RS19250	COG3485	protocatechuate 3,4-dioxygenase
DSM109990_RS19270	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM109990_RS19340	COG0439	Biotin carboxylase
DSM109990_RS19345	COG0509	glycine decarboxylation via glycine cleavage system
DSM109990_RS19375	COG3547	Transposase (IS116 IS110 IS902 family)
DSM109990_RS19380	COG3547	Transposase (IS116 IS110 IS902 family)
DSM109990_RS19385	COG1484	DNA-dependent DNA replication
DSM109990_RS19405	COG3328	transposase activity
DSM109990_RS19435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM109990_RS19440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM109990_RS19440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM109990_RS19450	COG1024	Enoyl-CoA hydratase
DSM109990_RS19480	COG0625	glutathione transferase activity
DSM109990_RS19495	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM109990_RS19505	COG1192	Involved in chromosome partitioning
DSM109990_RS19510	COG1475	DNA binding
DSM109990_RS19515	COG0640	Transcriptional regulator
DSM109990_RS19590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM109990_RS19660	COG2948	multi-organism process
DSM109990_RS19680	COG0739	heme binding
DSM109990_RS19680	COG0741	lytic transglycosylase activity
DSM109990_RS19680	COG1196	nuclear chromosome segregation
DSM109990_RS19705	COG0739	heme binding
DSM109990_RS19705	COG0741	lytic transglycosylase activity
DSM109990_RS19705	COG1196	nuclear chromosome segregation
DSM109990_RS19740	COG2826	transposase and inactivated derivatives, IS30 family
DSM109990_RS19765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM109990_RS19840	COG0785	Cytochrome C biogenesis protein
DSM109990_RS19865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM109990_RS19870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM109990_RS19885	COG2132	Multicopper oxidase
DSM109990_RS19910	COG0789	Transcriptional regulator
DSM109990_RS19915	COG1999	signal sequence binding
DSM109990_RS19925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DSM109990_RS19925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DSM109990_RS19935	COG1999	signal sequence binding
DSM109990_RS19955	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DSM109990_RS19960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DSM109990_RS19970	COG2366	antibiotic biosynthetic process
DSM109990_RS19980	COG3034	peptidoglycan biosynthetic process
DSM109990_RS20010	COG1321	iron dependent repressor
DSM109990_RS20015	COG2132	Multicopper oxidase
DSM109990_RS20035	COG1376	ErfK ybiS ycfS ynhG family protein
DSM109990_RS20050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DSM109990_RS20095	COG0183	Belongs to the thiolase family
DSM109990_RS20105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DSM109990_RS20110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DSM109990_RS20115	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS20125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM109990_RS20140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM109990_RS20150	COG1960	acyl-CoA dehydrogenase activity
DSM109990_RS20160	COG1024	Enoyl-CoA hydratase
DSM109990_RS20185	COG1024	Enoyl-CoA hydratase
DSM109990_RS20210	COG0583	DNA-binding transcription factor activity
DSM109990_RS20215	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DSM109990_RS20240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DSM109990_RS20270	COG4227	nucleotidyltransferase activity
DSM109990_RS20310	COG2076	Multidrug Resistance protein
DSM109990_RS20320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DSM109990_RS20350	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs