locus-tag	class	description
DSM110277_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DSM110277_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DSM110277_RS00035	COG1024	Enoyl-CoA hydratase
DSM110277_RS00080	COG1230	cation diffusion facilitator family transporter
DSM110277_RS00090	COG2378	regulation of single-species biofilm formation
DSM110277_RS00125	COG2514	catechol 2,3-dioxygenase activity
DSM110277_RS00130	COG4584	PFAM Integrase catalytic
DSM110277_RS00175	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DSM110277_RS00180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DSM110277_RS00195	COG0284	orotidine-5'-phosphate decarboxylase activity
DSM110277_RS00200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSM110277_RS00215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DSM110277_RS00220	COG0625	glutathione transferase activity
DSM110277_RS00225	COG1840	ABC-type Fe3 transport system, periplasmic component
DSM110277_RS00230	COG1178	ABC-type Fe3 transport system permease component
DSM110277_RS00235	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DSM110277_RS00255	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM110277_RS00295	COG3383	formate dehydrogenase (NAD+) activity
DSM110277_RS00360	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DSM110277_RS00365	COG3257	ureidoglycine aminohydrolase activity
DSM110277_RS00375	COG2351	hydroxyisourate hydrolase activity
DSM110277_RS00385	COG1012	belongs to the aldehyde dehydrogenase family
DSM110277_RS00390	COG0612	Peptidase, M16
DSM110277_RS00395	COG0612	Peptidase, M16
DSM110277_RS00410	COG0138	bifunctional purine biosynthesis protein purh
DSM110277_RS00420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DSM110277_RS00420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM110277_RS00435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DSM110277_RS00440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DSM110277_RS00445	COG3698	Phosphodiester glycosidase
DSM110277_RS00450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DSM110277_RS00465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DSM110277_RS00475	COG1185	polyribonucleotide nucleotidyltransferase activity
DSM110277_RS00505	COG0489	protein tyrosine kinase activity
DSM110277_RS00540	COG3383	formate dehydrogenase (NAD+) activity
DSM110277_RS00540	COG0243	molybdopterin cofactor binding
DSM110277_RS00545	COG0437	4 iron, 4 sulfur cluster binding
DSM110277_RS00560	COG3842	ATPase activity
DSM110277_RS00575	COG0450	alkyl hydroperoxide reductase
DSM110277_RS00585	COG0564	pseudouridine synthase activity
DSM110277_RS00610	COG0183	Belongs to the thiolase family
DSM110277_RS00615	COG1366	Belongs to the anti-sigma-factor antagonist family
DSM110277_RS00625	COG0405	Gamma-glutamyltransferase
DSM110277_RS00650	COG1674	ftsk spoiiie
DSM110277_RS00655	COG0436	Aminotransferase
DSM110277_RS00660	COG0154	amidase activity
DSM110277_RS00665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM110277_RS00670	COG2835	tetraacyldisaccharide 4'-kinase activity
DSM110277_RS00690	COG0745	RESPONSE REGULATOR receiver
DSM110277_RS00705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DSM110277_RS00720	COG0495	leucyl-tRNA aminoacylation
DSM110277_RS00760	COG0312	modulator of DNA gyrase
DSM110277_RS00775	COG1519	Transferase
DSM110277_RS00780	COG1663	tetraacyldisaccharide 4'-kinase activity
DSM110277_RS00800	COG1194	a g-specific adenine glycosylase
DSM110277_RS00815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DSM110277_RS00835	COG1609	Transcriptional regulator
DSM110277_RS00840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110277_RS00855	COG0129	dihydroxy-acid dehydratase activity
DSM110277_RS00875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DSM110277_RS00885	COG0288	reversible hydration of carbon dioxide
DSM110277_RS00895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM110277_RS00900	COG0791	NLP P60 protein
DSM110277_RS00910	COG2050	protein possibly involved in aromatic compounds catabolism
DSM110277_RS00925	COG0679	Auxin Efflux Carrier
DSM110277_RS00930	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DSM110277_RS00935	COG1671	Belongs to the UPF0178 family
DSM110277_RS00945	COG2423	ornithine cyclodeaminase activity
DSM110277_RS00950	COG0596	Alpha beta hydrolase
DSM110277_RS00960	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DSM110277_RS00970	COG0285	dihydrofolate synthase activity
DSM110277_RS00975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DSM110277_RS00985	COG2274	protein secretion by the type I secretion system
DSM110277_RS00990	COG0129	dihydroxy-acid dehydratase activity
DSM110277_RS01010	COG0569	domain protein
DSM110277_RS01015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM110277_RS01020	COG0793	Belongs to the peptidase S41A family
DSM110277_RS01030	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DSM110277_RS01045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM110277_RS01045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM110277_RS01050	COG3622	Belongs to the hyi family
DSM110277_RS01060	COG0714	Associated with various cellular activities
DSM110277_RS01090	COG3022	response to hydroperoxide
DSM110277_RS01095	COG0514	ATP-dependent DNA helicase (RecQ)
DSM110277_RS01115	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
DSM110277_RS01125	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DSM110277_RS01140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DSM110277_RS01145	COG2095	MarC family integral membrane protein
DSM110277_RS01150	COG1335	isochorismatase
DSM110277_RS01155	COG1054	Belongs to the UPF0176 family
DSM110277_RS01160	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DSM110277_RS01165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110277_RS01170	COG1177	transmembrane transport
DSM110277_RS01175	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM110277_RS01180	COG3842	ATPase activity
DSM110277_RS01190	COG1802	Transcriptional regulator
DSM110277_RS01200	COG3842	ATPase activity
DSM110277_RS01220	COG2951	lytic endotransglycosylase activity
DSM110277_RS01225	COG0557	exoribonuclease II activity
DSM110277_RS01240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM110277_RS01255	COG2171	N-acyltransferase activity
DSM110277_RS01270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DSM110277_RS01285	COG0560	Phosphoserine phosphatase
DSM110277_RS01290	COG0183	Belongs to the thiolase family
DSM110277_RS01295	COG3396	Phenylacetate-CoA oxygenase
DSM110277_RS01300	COG3460	Phenylacetate-CoA oxygenase
DSM110277_RS01305	COG3396	Phenylacetate-CoA oxygenase
DSM110277_RS01310	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM110277_RS01315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DSM110277_RS01320	COG2030	dehydratase
DSM110277_RS01320	COG1012	belongs to the aldehyde dehydrogenase family
DSM110277_RS01335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DSM110277_RS01335	COG0517	IMP dehydrogenase activity
DSM110277_RS01350	COG1137	ATPase activity
DSM110277_RS01355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DSM110277_RS01360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM110277_RS01385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DSM110277_RS01395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DSM110277_RS01415	COG0443	Heat shock 70 kDa protein
DSM110277_RS01420	COG0484	heat shock protein binding
DSM110277_RS01425	COG2003	Belongs to the UPF0758 family
DSM110277_RS01445	COG3206	protein involved in exopolysaccharide biosynthesis
DSM110277_RS01445	COG0489	protein tyrosine kinase activity
DSM110277_RS01455	COG3008	intermembrane lipid transfer
DSM110277_RS01455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DSM110277_RS01460	COG2995	paraquat-inducible protein a
DSM110277_RS01470	COG0693	protein deglycase activity
DSM110277_RS01505	COG0069	glutamate synthase activity
DSM110277_RS01510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DSM110277_RS01515	COG1396	sequence-specific DNA binding
DSM110277_RS01540	COG0784	Response regulator, receiver
DSM110277_RS01565	COG1295	ribonuclease BN
DSM110277_RS01570	COG2116	formate transmembrane transporter activity
DSM110277_RS01580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM110277_RS01585	COG0443	Heat shock 70 kDa protein
DSM110277_RS01590	COG0747	negative chemotaxis
DSM110277_RS01625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM110277_RS01645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110277_RS01655	COG3191	aminopeptidase activity
DSM110277_RS01660	COG3474	cytochrome
DSM110277_RS01690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DSM110277_RS01695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DSM110277_RS01700	COG2350	Protein conserved in bacteria
DSM110277_RS01715	COG1858	cytochrome C peroxidase
DSM110277_RS01725	COG1940	carbohydrate kinase activity
DSM110277_RS01730	COG4213	ABC transporter substrate-binding protein
DSM110277_RS01735	COG4214	carbohydrate transport
DSM110277_RS01740	COG1129	ABC transporter
DSM110277_RS01745	COG1070	Carbohydrate kinase
DSM110277_RS01750	COG2115	Belongs to the xylose isomerase family
DSM110277_RS01760	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DSM110277_RS01770	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DSM110277_RS01780	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DSM110277_RS01785	COG1999	signal sequence binding
DSM110277_RS01795	COG2205	protein histidine kinase activity
DSM110277_RS01800	COG0802	atpase or kinase
DSM110277_RS01805	COG3178	'Phosphotransferase
DSM110277_RS01810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DSM110277_RS01820	COG1074	ATP-dependent DNA helicase activity
DSM110277_RS01835	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DSM110277_RS01840	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DSM110277_RS01870	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DSM110277_RS01875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DSM110277_RS01880	COG0237	dephospho-CoA kinase activity
DSM110277_RS01885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DSM110277_RS01890	COG0424	maF-like protein
DSM110277_RS01895	COG1981	membrane
DSM110277_RS01900	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DSM110277_RS01905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DSM110277_RS01910	COG0445	tRNA wobble uridine modification
DSM110277_RS01915	COG0357	Ribosomal RNA small subunit methyltransferase G
DSM110277_RS01930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DSM110277_RS01935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DSM110277_RS01940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DSM110277_RS01950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DSM110277_RS01955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DSM110277_RS01960	COG0280	phosphate acetyltransferase
DSM110277_RS01960	COG0281	malic enzyme
DSM110277_RS01970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM110277_RS01975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSM110277_RS01990	COG0137	argininosuccinate synthase activity
DSM110277_RS01995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM110277_RS02020	COG0494	nUDIX hydrolase
DSM110277_RS02025	COG0617	tRNA 3'-terminal CCA addition
DSM110277_RS02030	COG1132	(ABC) transporter
DSM110277_RS02035	COG1132	(ABC) transporter
DSM110277_RS02050	COG3034	peptidoglycan biosynthetic process
DSM110277_RS02080	COG1040	competence protein
DSM110277_RS02090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSM110277_RS02100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM110277_RS02115	COG0779	Required for maturation of 30S ribosomal subunits
DSM110277_RS02130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DSM110277_RS02140	COG1803	Methylglyoxal synthase
DSM110277_RS02140	COG1597	lipid kinase activity
DSM110277_RS02145	COG0494	nUDIX hydrolase
DSM110277_RS02150	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DSM110277_RS02155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM110277_RS02160	COG0653	protein targeting
DSM110277_RS02175	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DSM110277_RS02180	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM110277_RS02195	COG0463	Glycosyl transferase, family 2
DSM110277_RS02270	COG0110	maltose O-acetyltransferase activity
DSM110277_RS02280	COG0709	Synthesizes selenophosphate from selenide and ATP
DSM110277_RS02290	COG4717	serine-type aminopeptidase activity
DSM110277_RS02340	COG1968	undecaprenyl-diphosphatase activity
DSM110277_RS02360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DSM110277_RS02370	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DSM110277_RS02380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM110277_RS02390	COG0697	spore germination
DSM110277_RS02400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DSM110277_RS02405	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DSM110277_RS02410	COG0438	transferase activity, transferring glycosyl groups
DSM110277_RS02425	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DSM110277_RS02430	COG1178	ABC-type Fe3 transport system permease component
DSM110277_RS02435	COG4143	(ABC) transporter
DSM110277_RS02440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DSM110277_RS02455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSM110277_RS02460	COG1846	Transcriptional regulator
DSM110277_RS02465	COG0745	RESPONSE REGULATOR receiver
DSM110277_RS02470	COG1722	exodeoxyribonuclease VII activity
DSM110277_RS02475	COG0142	geranyltranstransferase activity
DSM110277_RS02480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DSM110277_RS02490	COG2808	Putative FMN-binding domain
DSM110277_RS02495	COG0625	glutathione transferase activity
DSM110277_RS02520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM110277_RS02525	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DSM110277_RS02535	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DSM110277_RS02545	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DSM110277_RS02560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM110277_RS02565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110277_RS02570	COG3214	Protein conserved in bacteria
DSM110277_RS02575	COG1609	Transcriptional regulator
DSM110277_RS02595	COG3707	response regulator
DSM110277_RS02600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM110277_RS02600	COG1116	anion transmembrane transporter activity
DSM110277_RS02605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM110277_RS02610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM110277_RS02615	COG1116	anion transmembrane transporter activity
DSM110277_RS02615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM110277_RS02620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DSM110277_RS02625	COG2146	nitrite reductase [NAD(P)H] activity
DSM110277_RS02630	COG0243	molybdopterin cofactor binding
DSM110277_RS02635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM110277_RS02640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DSM110277_RS02640	COG1648	precorrin-2 dehydrogenase activity
DSM110277_RS02650	COG4774	siderophore transport
DSM110277_RS02655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DSM110277_RS02660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM110277_RS02665	COG1120	ATPase activity
DSM110277_RS02670	COG1132	(ABC) transporter
DSM110277_RS02675	COG0642	Histidine kinase
DSM110277_RS02680	COG0745	RESPONSE REGULATOR receiver
DSM110277_RS02690	COG2194	sulfuric ester hydrolase activity
DSM110277_RS02700	COG0473	3-isopropylmalate dehydrogenase activity
DSM110277_RS02715	COG0066	3-isopropylmalate dehydratase activity
DSM110277_RS02720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSM110277_RS02730	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DSM110277_RS02730	COG3264	Mechanosensitive ion channel
DSM110277_RS02735	COG0799	negative regulation of ribosome biogenesis
DSM110277_RS02740	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DSM110277_RS02755	COG0277	FAD linked oxidase domain protein
DSM110277_RS02760	COG0277	FAD linked oxidase domain protein
DSM110277_RS02770	COG0247	lactate metabolic process
DSM110277_RS02785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM110277_RS02790	COG1012	belongs to the aldehyde dehydrogenase family
DSM110277_RS02835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DSM110277_RS02840	COG2897	thiosulfate sulfurtransferase activity
DSM110277_RS02850	COG0004	ammonium transporteR
DSM110277_RS02855	COG0347	Belongs to the P(II) protein family
DSM110277_RS02870	COG0583	DNA-binding transcription factor activity
DSM110277_RS02875	COG2853	Lipoprotein
DSM110277_RS02885	COG0584	glycerophosphoryl diester phosphodiesterase
DSM110277_RS02895	COG2154	pterin-4-alpha-carbinolamine dehydratase
DSM110277_RS02900	COG0678	peroxiredoxin activity
DSM110277_RS02910	COG0742	ribosomal rna small subunit methyltransferase
DSM110277_RS02920	COG1183	phosphatidylcholine synthase activity
DSM110277_RS02925	COG0024	Methionine aminopeptidase
DSM110277_RS02930	COG1489	DNA binding
DSM110277_RS02935	COG1058	Belongs to the CinA family
DSM110277_RS02935	COG1546	Belongs to the CinA family
DSM110277_RS02955	COG0583	DNA-binding transcription factor activity
DSM110277_RS02965	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM110277_RS02965	COG1902	pentaerythritol trinitrate reductase activity
DSM110277_RS02970	COG1051	belongs to the nudix hydrolase family
DSM110277_RS02985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM110277_RS02990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DSM110277_RS02995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSM110277_RS03010	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DSM110277_RS03010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110277_RS03015	COG0697	spore germination
DSM110277_RS03020	COG0741	lytic transglycosylase activity
DSM110277_RS03025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM110277_RS03035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM110277_RS03055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DSM110277_RS03060	COG0830	nickel cation binding
DSM110277_RS03065	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DSM110277_RS03070	COG0804	urea catabolic process
DSM110277_RS03075	COG0832	Belongs to the urease beta subunit family
DSM110277_RS03085	COG0831	urea catabolic process
DSM110277_RS03090	COG0829	nickel cation binding
DSM110277_RS03110	COG1917	Cupin 2, conserved barrel domain protein
DSM110277_RS03110	COG2207	Transcriptional regulator
DSM110277_RS03125	COG1309	transcriptional regulator
DSM110277_RS03155	COG0825	malonyl-CoA metabolic process
DSM110277_RS03165	COG2301	Belongs to the HpcH HpaI aldolase family
DSM110277_RS03175	COG4948	Mandelate Racemase Muconate Lactonizing
DSM110277_RS03190	COG0469	pyruvate kinase activity
DSM110277_RS03200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DSM110277_RS03205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DSM110277_RS03215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DSM110277_RS03230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM110277_RS03230	COG0072	phenylalanine-tRNA ligase activity
DSM110277_RS03240	COG1970	mechanosensitive ion channel activity
DSM110277_RS03245	COG0686	Belongs to the AlaDH PNT family
DSM110277_RS03250	COG1522	sequence-specific DNA binding
DSM110277_RS03260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DSM110277_RS03270	COG1122	ATPase activity
DSM110277_RS03275	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DSM110277_RS03280	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS03280	COG3321	synthase
DSM110277_RS03280	COG0604	alcohol dehydrogenase
DSM110277_RS03295	COG2197	response regulator
DSM110277_RS03315	COG0019	diaminopimelate decarboxylase activity
DSM110277_RS03320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DSM110277_RS03335	COG0745	RESPONSE REGULATOR receiver
DSM110277_RS03340	COG0346	lactoylglutathione lyase activity
DSM110277_RS03355	COG0778	Nitroreductase
DSM110277_RS03365	COG0180	Tryptophanyl-tRNA synthetase
DSM110277_RS03375	COG0728	peptidoglycan biosynthetic process
DSM110277_RS03380	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DSM110277_RS03390	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DSM110277_RS03400	COG0189	ligase activity
DSM110277_RS03410	COG0606	chelatase, subunit chli
DSM110277_RS03425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DSM110277_RS03435	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DSM110277_RS03440	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DSM110277_RS03445	COG3639	organic phosphonate transmembrane transporter activity
DSM110277_RS03450	COG3639	organic phosphonate transmembrane transporter activity
DSM110277_RS03460	COG2188	Transcriptional regulator
DSM110277_RS03465	COG3624	Phosphonate C-P lyase system protein PhnG
DSM110277_RS03470	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
DSM110277_RS03475	COG3626	phosphonate metabolism
DSM110277_RS03480	COG3627	carbon phosphorus lyase activity
DSM110277_RS03485	COG4107	phosphonate C-P lyase system protein PhnK
DSM110277_RS03490	COG4778	phosphonate C-P lyase system protein PhnL
DSM110277_RS03500	COG3454	Phosphonate metabolism
DSM110277_RS03505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSM110277_RS03510	COG0339	signal peptide processing
DSM110277_RS03515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM110277_RS03520	COG0772	Belongs to the SEDS family
DSM110277_RS03525	COG0768	penicillin binding
DSM110277_RS03555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM110277_RS03565	COG3046	protein related to deoxyribodipyrimidine photolyase
DSM110277_RS03580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM110277_RS03595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM110277_RS03600	COG0509	glycine decarboxylation via glycine cleavage system
DSM110277_RS03605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM110277_RS03605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM110277_RS03615	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DSM110277_RS03620	COG4181	ATPase activity
DSM110277_RS03630	COG1278	Cold shock
DSM110277_RS03635	COG0493	'glutamate synthase
DSM110277_RS03645	COG1309	transcriptional regulator
DSM110277_RS03670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM110277_RS03675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM110277_RS03680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM110277_RS03685	COG1376	ErfK ybiS ycfS ynhG family protein
DSM110277_RS03690	COG1278	Cold shock
DSM110277_RS03700	COG0488	(ABC) transporter
DSM110277_RS03710	COG1115	amino acid carrier protein
DSM110277_RS03715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DSM110277_RS03725	COG2027	D-alanyl-D-alanine carboxypeptidase
DSM110277_RS03735	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DSM110277_RS03775	COG0556	nucleotide-excision repair
DSM110277_RS03795	COG1921	L-seryl-tRNASec selenium transferase activity
DSM110277_RS03825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DSM110277_RS03830	COG2971	BadF BadG BcrA BcrD
DSM110277_RS03835	COG0129	dihydroxy-acid dehydratase activity
DSM110277_RS03840	COG0800	Aldolase
DSM110277_RS03860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM110277_RS03865	COG0165	Argininosuccinate lyase
DSM110277_RS03880	COG0019	diaminopimelate decarboxylase activity
DSM110277_RS03895	COG2884	Cell division ATP-binding protein ftsE
DSM110277_RS03925	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM110277_RS03950	COG0045	succinate-CoA ligase (ADP-forming) activity
DSM110277_RS03955	COG2030	dehydratase
DSM110277_RS03985	COG0039	L-malate dehydrogenase activity
DSM110277_RS04030	COG0813	purine-nucleoside phosphorylase activity
DSM110277_RS04040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM110277_RS04040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM110277_RS04045	COG2937	Belongs to the GPAT DAPAT family
DSM110277_RS04050	COG0604	alcohol dehydrogenase
DSM110277_RS04055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DSM110277_RS04065	COG0730	response to heat
DSM110277_RS04070	COG1079	Belongs to the binding-protein-dependent transport system permease family
DSM110277_RS04075	COG4603	Belongs to the binding-protein-dependent transport system permease family
DSM110277_RS04080	COG3845	ABC transporter
DSM110277_RS04085	COG1744	ABC transporter substrate-binding protein PnrA-like
DSM110277_RS04090	COG0456	acetyltransferase
DSM110277_RS04095	COG1214	PFAM Peptidase M22, glycoprotease
DSM110277_RS04100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DSM110277_RS04130	COG1272	protein, Hemolysin III
DSM110277_RS04140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM110277_RS04150	COG0133	tryptophan synthase activity
DSM110277_RS04175	COG0193	aminoacyl-tRNA hydrolase activity
DSM110277_RS04180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DSM110277_RS04190	COG0159	tryptophan synthase activity
DSM110277_RS04200	COG0012	GTP binding
DSM110277_RS04210	COG4221	oxidoreductase activity
DSM110277_RS04215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM110277_RS04235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM110277_RS04245	COG1643	Atp-dependent helicase
DSM110277_RS04250	COG1703	isobutyryl-CoA mutase activity
DSM110277_RS04265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DSM110277_RS04300	COG0632	four-way junction helicase activity
DSM110277_RS04305	COG2255	four-way junction helicase activity
DSM110277_RS04315	COG0824	Thioesterase
DSM110277_RS04335	COG0823	Involved in the tonB-independent uptake of proteins
DSM110277_RS04340	COG2885	chlorophyll binding
DSM110277_RS04350	COG0037	tRNA processing
DSM110277_RS04355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM110277_RS04365	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DSM110277_RS04370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DSM110277_RS04385	COG1201	RNA secondary structure unwinding
DSM110277_RS04435	COG4964	Belongs to the GSP D family
DSM110277_RS04450	COG0741	lytic transglycosylase activity
DSM110277_RS04455	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DSM110277_RS04470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DSM110277_RS04470	COG1754	DNA topoisomerase type I activity
DSM110277_RS04475	COG0758	DNA mediated transformation
DSM110277_RS04480	COG0312	modulator of DNA gyrase
DSM110277_RS04490	COG0109	protoheme IX farnesyltransferase activity
DSM110277_RS04500	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DSM110277_RS04510	COG3346	SURF1 family
DSM110277_RS04520	COG0612	Peptidase, M16
DSM110277_RS04540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSM110277_RS04545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DSM110277_RS04555	COG0306	phosphate transporter
DSM110277_RS04565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DSM110277_RS04570	COG0101	tRNA pseudouridine synthase activity
DSM110277_RS04575	COG3106	COG3106 Predicted ATPase
DSM110277_RS04585	COG3768	UPF0283 membrane protein
DSM110277_RS04590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DSM110277_RS04600	COG1183	phosphatidylcholine synthase activity
DSM110277_RS04605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DSM110277_RS04620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DSM110277_RS04625	COG0583	DNA-binding transcription factor activity
DSM110277_RS04630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSM110277_RS04635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DSM110277_RS04640	COG0424	maF-like protein
DSM110277_RS04650	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DSM110277_RS04665	COG0583	DNA-binding transcription factor activity
DSM110277_RS04670	COG2388	GCN5-related N-acetyl-transferase
DSM110277_RS04685	COG0604	alcohol dehydrogenase
DSM110277_RS04685	COG3321	synthase
DSM110277_RS04690	COG1024	Enoyl-CoA hydratase
DSM110277_RS04695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DSM110277_RS04700	COG0022	dehydrogenase e1 component
DSM110277_RS04710	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM110277_RS04715	COG0095	Lipoate-protein ligase
DSM110277_RS04725	COG2204	response regulator
DSM110277_RS04760	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DSM110277_RS04785	COG1172	Belongs to the binding-protein-dependent transport system permease family
DSM110277_RS04800	COG0784	Response regulator, receiver
DSM110277_RS04800	COG2205	protein histidine kinase activity
DSM110277_RS04800	COG5002	protein histidine kinase activity
DSM110277_RS04810	COG2323	membrane
DSM110277_RS04825	COG0848	biopolymer transport protein
DSM110277_RS04835	COG3128	pkhd-type hydroxylase
DSM110277_RS04840	COG4774	siderophore transport
DSM110277_RS04855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSM110277_RS04865	COG0778	Nitroreductase
DSM110277_RS04885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DSM110277_RS04895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DSM110277_RS04900	COG5328	Belongs to the UPF0262 family
DSM110277_RS04920	COG0481	GTPase activity
DSM110277_RS04935	COG0588	phosphoglycerate mutase activity
DSM110277_RS04940	COG0438	transferase activity, transferring glycosyl groups
DSM110277_RS04955	COG0668	transmembrane transport
DSM110277_RS04960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DSM110277_RS04965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110277_RS04970	COG0601	transmembrane transport
DSM110277_RS04975	COG0747	negative chemotaxis
DSM110277_RS04980	COG4172	Belongs to the ABC transporter superfamily
DSM110277_RS05010	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM110277_RS05010	COG1024	Enoyl-CoA hydratase
DSM110277_RS05015	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS05020	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS05030	COG1024	Enoyl-CoA hydratase
DSM110277_RS05035	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110277_RS05055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM110277_RS05080	COG0785	Cytochrome C biogenesis protein
DSM110277_RS05105	COG3258	Cytochrome c
DSM110277_RS05110	COG0737	Belongs to the 5'-nucleotidase family
DSM110277_RS05140	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110277_RS05145	COG0028	Belongs to the TPP enzyme family
DSM110277_RS05150	COG0668	transmembrane transport
DSM110277_RS05160	COG2943	transferase activity, transferring hexosyl groups
DSM110277_RS05170	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DSM110277_RS05175	COG1757	Na H antiporter
DSM110277_RS05180	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110277_RS05185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM110277_RS05190	COG3608	succinylglutamate desuccinylase aspartoacylase
DSM110277_RS05195	COG0006	proline dipeptidase activity
DSM110277_RS05200	COG1522	sequence-specific DNA binding
DSM110277_RS05210	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DSM110277_RS05215	COG2202	Pas domain
DSM110277_RS05215	COG3920	Histidine kinase
DSM110277_RS05220	COG0784	Response regulator, receiver
DSM110277_RS05220	COG4191	Histidine kinase
DSM110277_RS05250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM110277_RS05255	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DSM110277_RS05260	COG2080	2 iron, 2 sulfur cluster binding
DSM110277_RS05265	COG0583	DNA-binding transcription factor activity
DSM110277_RS05270	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS05290	COG3321	synthase
DSM110277_RS05290	COG0604	alcohol dehydrogenase
DSM110277_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS05310	COG0277	FAD linked oxidase domain protein
DSM110277_RS05325	COG3757	hydrolase, family 25
DSM110277_RS05340	COG0625	glutathione transferase activity
DSM110277_RS05360	COG1079	Belongs to the binding-protein-dependent transport system permease family
DSM110277_RS05365	COG4603	Belongs to the binding-protein-dependent transport system permease family
DSM110277_RS05370	COG3845	ABC transporter
DSM110277_RS05380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM110277_RS05395	COG2900	Belongs to the SlyX family
DSM110277_RS05400	COG0124	histidyl-tRNA synthetase
DSM110277_RS05405	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DSM110277_RS05410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DSM110277_RS05430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM110277_RS05455	COG0798	PFAM Bile acid sodium symporter
DSM110277_RS05465	COG0431	NADPH-dependent FMN reductase
DSM110277_RS05475	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
DSM110277_RS05505	COG1175	transmembrane transport
DSM110277_RS05510	COG0395	ABC-type sugar transport system, permease component
DSM110277_RS05520	COG0129	dihydroxy-acid dehydratase activity
DSM110277_RS05525	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS05530	COG3734	2-keto-3-deoxy-galactonokinase
DSM110277_RS05535	COG0800	Aldolase
DSM110277_RS05540	COG3386	PFAM SMP-30 Gluconolaconase
DSM110277_RS05550	COG1464	Belongs to the NlpA lipoprotein family
DSM110277_RS05555	COG2011	ABC-type metal ion transport system permease component
DSM110277_RS05560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DSM110277_RS05575	COG1522	sequence-specific DNA binding
DSM110277_RS05595	COG3268	Saccharopine dehydrogenase
DSM110277_RS05600	COG1115	amino acid carrier protein
DSM110277_RS05605	COG0252	asparaginase activity
DSM110277_RS05630	COG3443	Belongs to the bacterial solute-binding protein 9 family
DSM110277_RS05635	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM110277_RS05650	COG0154	amidase activity
DSM110277_RS05670	COG3483	tryptophan 2,3-dioxygenase activity
DSM110277_RS05680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM110277_RS05685	COG0589	response to stress
DSM110277_RS05690	COG0583	DNA-binding transcription factor activity
DSM110277_RS05720	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DSM110277_RS05745	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DSM110277_RS05750	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DSM110277_RS05765	COG2951	lytic endotransglycosylase activity
DSM110277_RS05775	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DSM110277_RS05810	COG3246	L-lysine catabolic process to acetate
DSM110277_RS05815	COG3485	protocatechuate 3,4-dioxygenase
DSM110277_RS05820	COG3485	protocatechuate 3,4-dioxygenase
DSM110277_RS05825	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DSM110277_RS05830	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DSM110277_RS05835	COG2080	2 iron, 2 sulfur cluster binding
DSM110277_RS05840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM110277_RS05840	COG2010	Cytochrome c
DSM110277_RS05850	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110277_RS05860	COG1132	(ABC) transporter
DSM110277_RS05865	COG1652	LysM domain
DSM110277_RS05870	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110277_RS05875	COG0657	acetylesterase activity
DSM110277_RS05885	COG4172	Belongs to the ABC transporter superfamily
DSM110277_RS05890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110277_RS05930	COG1490	D-aminoacyl-tRNA deacylase activity
DSM110277_RS05975	COG1187	pseudouridine synthase activity
DSM110277_RS05980	COG0590	tRNA wobble adenosine to inosine editing
DSM110277_RS05995	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DSM110277_RS06000	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM110277_RS06005	COG0154	amidase activity
DSM110277_RS06025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DSM110277_RS06035	COG0670	Belongs to the BI1 family
DSM110277_RS06040	COG1396	sequence-specific DNA binding
DSM110277_RS06045	COG0483	inositol monophosphate 1-phosphatase activity
DSM110277_RS06060	COG0402	S-adenosylhomocysteine deaminase activity
DSM110277_RS06065	COG2239	Acts as a magnesium transporter
DSM110277_RS06070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DSM110277_RS06075	COG1692	metallophosphoesterase
DSM110277_RS06080	COG0471	metal ion transport
DSM110277_RS06080	COG3273	potassium ion transport
DSM110277_RS06085	COG0471	metal ion transport
DSM110277_RS06085	COG3273	potassium ion transport
DSM110277_RS06090	COG0217	transcriptional regulatory protein
DSM110277_RS06110	COG1309	transcriptional regulator
DSM110277_RS06115	COG3119	arylsulfatase activity
DSM110277_RS06140	COG1396	sequence-specific DNA binding
DSM110277_RS06140	COG3800	Transcriptional regulator
DSM110277_RS06145	COG2814	Major facilitator Superfamily
DSM110277_RS06150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM110277_RS06175	COG4770	biotin carboxylase activity
DSM110277_RS06190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM110277_RS06190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM110277_RS06205	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DSM110277_RS06220	COG0248	Ppx GppA phosphatase
DSM110277_RS06225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DSM110277_RS06235	COG0628	permease
DSM110277_RS06245	COG0442	prolyl-tRNA aminoacylation
DSM110277_RS06260	COG1136	(ABC) transporter
DSM110277_RS06290	COG0187	DNA topoisomerase II activity
DSM110277_RS06295	COG0662	Cupin 2, conserved barrel domain protein
DSM110277_RS06300	COG0596	Alpha beta hydrolase
DSM110277_RS06310	COG0534	Mate efflux family protein
DSM110277_RS06365	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DSM110277_RS06385	COG1278	Cold shock
DSM110277_RS06390	COG1393	Belongs to the ArsC family
DSM110277_RS06405	COG3220	belongs to the UPF0276 family
DSM110277_RS06415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DSM110277_RS06455	COG3243	poly(R)-hydroxyalkanoic acid synthase
DSM110277_RS06470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM110277_RS06475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110277_RS06480	COG0174	glutamine synthetase
DSM110277_RS06485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DSM110277_RS06485	COG0519	Catalyzes the synthesis of GMP from XMP
DSM110277_RS06490	COG0174	glutamine synthetase
DSM110277_RS06495	COG0765	amino acid transport
DSM110277_RS06500	COG4215	(ABC) transporter
DSM110277_RS06530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DSM110277_RS06535	COG0504	CTP synthase activity
DSM110277_RS06550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSM110277_RS06585	COG0546	phosphoglycolate phosphatase activity
DSM110277_RS06605	COG1215	transferase activity, transferring glycosyl groups
DSM110277_RS06615	COG3620	sequence-specific DNA binding
DSM110277_RS06620	COG0747	negative chemotaxis
DSM110277_RS06630	COG0601	transmembrane transport
DSM110277_RS06635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110277_RS06640	COG0444	Belongs to the ABC transporter superfamily
DSM110277_RS06645	COG4608	Belongs to the ABC transporter superfamily
DSM110277_RS06665	COG3448	diguanylate cyclase activity
DSM110277_RS06665	COG4175	Glycine betaine
DSM110277_RS06670	COG0697	spore germination
DSM110277_RS06675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DSM110277_RS06680	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DSM110277_RS06695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM110277_RS06715	COG2207	Transcriptional regulator
DSM110277_RS06715	COG3708	Transcriptional regulator
DSM110277_RS06730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DSM110277_RS06755	COG1760	l-serine dehydratase
DSM110277_RS06760	COG0625	glutathione transferase activity
DSM110277_RS06765	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DSM110277_RS06775	COG0330	HflC and HflK could
DSM110277_RS06780	COG0330	HflC and HflK could
DSM110277_RS06785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM110277_RS06805	COG1121	(ABC) transporter
DSM110277_RS06810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSM110277_RS06815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSM110277_RS06820	COG0395	ABC-type sugar transport system, permease component
DSM110277_RS06825	COG1175	transmembrane transport
DSM110277_RS06830	COG1349	DNA-binding transcription factor activity
DSM110277_RS06840	COG3842	ATPase activity
DSM110277_RS06845	COG3842	ATPase activity
DSM110277_RS06855	COG0395	ABC-type sugar transport system, permease component
DSM110277_RS06870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DSM110277_RS06880	COG1454	alcohol dehydrogenase
DSM110277_RS06885	COG0730	response to heat
DSM110277_RS06890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSM110277_RS06905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DSM110277_RS06910	COG4235	cytochrome complex assembly
DSM110277_RS06915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110277_RS06930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM110277_RS06930	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM110277_RS06965	COG5265	(ABC) transporter
DSM110277_RS06975	COG2814	Major facilitator Superfamily
DSM110277_RS06980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM110277_RS07000	COG1160	GTP binding
DSM110277_RS07010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DSM110277_RS07015	COG1862	Preprotein translocase
DSM110277_RS07020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM110277_RS07025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM110277_RS07030	COG3737	Protein of unknown function (DUF498/DUF598)
DSM110277_RS07035	COG4133	protoheme IX ABC transporter activity
DSM110277_RS07040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM110277_RS07045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM110277_RS07055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM110277_RS07085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DSM110277_RS07085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DSM110277_RS07110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DSM110277_RS07135	COG0586	Pfam SNARE associated Golgi protein
DSM110277_RS07140	COG0598	Magnesium transport protein CorA
DSM110277_RS07145	COG0668	transmembrane transport
DSM110277_RS07170	COG2205	protein histidine kinase activity
DSM110277_RS07190	COG0668	transmembrane transport
DSM110277_RS07210	COG0463	Glycosyl transferase, family 2
DSM110277_RS07215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DSM110277_RS07235	COG0671	phosphoesterase, PA-phosphatase related
DSM110277_RS07240	COG2433	Pfam Transposase IS66
DSM110277_RS07245	COG3436	PFAM IS66 Orf2 family protein
DSM110277_RS07370	COG1234	tRNA 3'-trailer cleavage
DSM110277_RS07375	COG0084	hydrolase, TatD family'
DSM110277_RS07385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DSM110277_RS07390	COG1686	Belongs to the peptidase S11 family
DSM110277_RS07410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM110277_RS07430	COG2205	protein histidine kinase activity
DSM110277_RS07430	COG2202	Pas domain
DSM110277_RS07435	COG1349	DNA-binding transcription factor activity
DSM110277_RS07450	COG3639	organic phosphonate transmembrane transporter activity
DSM110277_RS07460	COG1011	Hydrolase
DSM110277_RS07475	COG0811	peptide transport
DSM110277_RS07505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSM110277_RS07510	COG1121	(ABC) transporter
DSM110277_RS07540	COG0740	serine-type endopeptidase activity
DSM110277_RS07545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DSM110277_RS07565	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DSM110277_RS07570	COG0439	Biotin carboxylase
DSM110277_RS07575	COG0511	ligase activity, forming carbon-carbon bonds
DSM110277_RS07580	COG0410	ABC transporter
DSM110277_RS07605	COG1396	sequence-specific DNA binding
DSM110277_RS07605	COG3800	Transcriptional regulator
DSM110277_RS07645	COG3750	Belongs to the UPF0335 family
DSM110277_RS07650	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSM110277_RS07665	COG0359	binds to the 23S rRNA
DSM110277_RS07670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DSM110277_RS07675	COG0360	Binds together with S18 to 16S ribosomal RNA
DSM110277_RS07685	COG2353	YceI-like domain
DSM110277_RS07690	COG3038	cytochrome b561
DSM110277_RS07695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DSM110277_RS07705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DSM110277_RS07715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM110277_RS07720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DSM110277_RS07735	COG4695	Portal protein
DSM110277_RS07815	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM110277_RS07820	COG0022	dehydrogenase e1 component
DSM110277_RS07820	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM110277_RS07825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DSM110277_RS07835	COG0126	phosphoglycerate kinase activity
DSM110277_RS07855	COG0739	heme binding
DSM110277_RS07860	COG2833	Protein of unknown function (DUF455)
DSM110277_RS07865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSM110277_RS07875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DSM110277_RS07880	COG2814	Major facilitator Superfamily
DSM110277_RS07890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM110277_RS07895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DSM110277_RS07935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DSM110277_RS07955	COG2354	Protein conserved in bacteria
DSM110277_RS07965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DSM110277_RS07985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DSM110277_RS08000	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DSM110277_RS08025	COG2885	chlorophyll binding
DSM110277_RS08030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DSM110277_RS08050	COG0175	sulfate reduction
DSM110277_RS08055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DSM110277_RS08065	COG1648	precorrin-2 dehydrogenase activity
DSM110277_RS08065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DSM110277_RS08070	COG1522	sequence-specific DNA binding
DSM110277_RS08075	COG2124	cytochrome p450
DSM110277_RS08090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110277_RS08095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM110277_RS08100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110277_RS08105	COG0149	triose-phosphate isomerase activity
DSM110277_RS08110	COG0316	Belongs to the HesB IscA family
DSM110277_RS08120	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM110277_RS08125	COG4067	protein conserved in archaea
DSM110277_RS08125	COG0189	ligase activity
DSM110277_RS08130	COG0343	queuine tRNA-ribosyltransferase activity
DSM110277_RS08135	COG1902	pentaerythritol trinitrate reductase activity
DSM110277_RS08140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM110277_RS08145	COG0776	regulation of translation
DSM110277_RS08190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DSM110277_RS08225	COG1024	Enoyl-CoA hydratase
DSM110277_RS08230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM110277_RS08235	COG1116	anion transmembrane transporter activity
DSM110277_RS08240	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DSM110277_RS08245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM110277_RS08250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSM110277_RS08260	COG2022	thiamine diphosphate biosynthetic process
DSM110277_RS08275	COG0351	phosphomethylpyrimidine kinase
DSM110277_RS08295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DSM110277_RS08310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DSM110277_RS08315	COG1268	BioY protein
DSM110277_RS08325	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
DSM110277_RS08335	COG1174	glycine betaine transport
DSM110277_RS08340	COG1125	glycine betaine transport
DSM110277_RS08345	COG1174	glycine betaine transport
DSM110277_RS08350	COG1732	Glycine betaine
DSM110277_RS08360	COG1473	amidohydrolase
DSM110277_RS08380	COG4681	YaeQ
DSM110277_RS08425	COG2205	protein histidine kinase activity
DSM110277_RS08425	COG2202	Pas domain
DSM110277_RS08430	COG0582	viral genome integration into host DNA
DSM110277_RS08435	COG4584	PFAM Integrase catalytic
DSM110277_RS08450	COG0583	DNA-binding transcription factor activity
DSM110277_RS08475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DSM110277_RS08475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM110277_RS08490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DSM110277_RS08495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSM110277_RS08505	COG1217	gtp-binding protein TYPA
DSM110277_RS08510	COG0668	transmembrane transport
DSM110277_RS08515	COG2076	Multidrug Resistance protein
DSM110277_RS08525	COG0538	isocitrate dehydrogenase activity
DSM110277_RS08540	COG2945	thiolester hydrolase activity
DSM110277_RS08545	COG1959	2 iron, 2 sulfur cluster binding
DSM110277_RS08555	COG0719	Fe-S assembly protein
DSM110277_RS08570	COG0396	ATPase activity
DSM110277_RS08575	COG0719	Fe-S assembly protein
DSM110277_RS08590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DSM110277_RS08600	COG2198	Histidine kinase
DSM110277_RS08600	COG2205	protein histidine kinase activity
DSM110277_RS08600	COG0784	Response regulator, receiver
DSM110277_RS08600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM110277_RS08610	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DSM110277_RS08620	COG0248	Ppx GppA phosphatase
DSM110277_RS08625	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DSM110277_RS08630	COG2111	Na H antiporter
DSM110277_RS08630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DSM110277_RS08635	COG1006	Multisubunit Na H antiporter MnhC subunit
DSM110277_RS08640	COG0651	ATP synthesis coupled electron transport
DSM110277_RS08645	COG1863	multisubunit Na H antiporter MnhE subunit
DSM110277_RS08650	COG2212	antiporter activity
DSM110277_RS08655	COG1320	monovalent cation:proton antiporter activity
DSM110277_RS08670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM110277_RS08675	COG0156	8-amino-7-oxononanoate synthase activity
DSM110277_RS08685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DSM110277_RS08710	COG0436	Aminotransferase
DSM110277_RS08720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DSM110277_RS08725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DSM110277_RS08745	COG0440	acetolactate synthase activity
DSM110277_RS08750	COG0028	Belongs to the TPP enzyme family
DSM110277_RS08765	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM110277_RS08780	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DSM110277_RS08795	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DSM110277_RS08825	COG1764	response to oxidative stress
DSM110277_RS08855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM110277_RS08865	COG0010	Belongs to the arginase family
DSM110277_RS08880	COG1238	metal cluster binding
DSM110277_RS08910	COG1175	transmembrane transport
DSM110277_RS08940	COG4536	flavin adenine dinucleotide binding
DSM110277_RS08950	COG4974	Belongs to the 'phage' integrase family
DSM110277_RS08965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DSM110277_RS08970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DSM110277_RS08975	COG0629	single-stranded DNA binding
DSM110277_RS08980	COG0739	heme binding
DSM110277_RS08980	COG1196	nuclear chromosome segregation
DSM110277_RS08980	COG0741	lytic transglycosylase activity
DSM110277_RS08995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110277_RS09000	COG0601	transmembrane transport
DSM110277_RS09010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DSM110277_RS09015	COG0528	UMP kinase activity
DSM110277_RS09020	COG0233	cytoplasmic translational termination
DSM110277_RS09025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DSM110277_RS09035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DSM110277_RS09040	COG0750	zinc metalloprotease
DSM110277_RS09045	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM110277_RS09055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM110277_RS09060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM110277_RS09065	COG3494	Protein of unknown function (DUF1009)
DSM110277_RS09070	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM110277_RS09075	COG0482	sulfurtransferase activity
DSM110277_RS09090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DSM110277_RS09095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DSM110277_RS09105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DSM110277_RS09110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM110277_RS09115	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DSM110277_RS09135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM110277_RS09140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DSM110277_RS09145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DSM110277_RS09150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM110277_RS09155	COG1309	transcriptional regulator
DSM110277_RS09160	COG2326	polyphosphate kinase activity
DSM110277_RS09165	COG0596	Alpha beta hydrolase
DSM110277_RS09170	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DSM110277_RS09185	COG0697	spore germination
DSM110277_RS09190	COG0519	Catalyzes the synthesis of GMP from XMP
DSM110277_RS09190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DSM110277_RS09195	COG5598	trimethylamine methyltransferase
DSM110277_RS09210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DSM110277_RS09220	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DSM110277_RS09225	COG2867	negative regulation of translational initiation
DSM110277_RS09230	COG0004	ammonium transporteR
DSM110277_RS09240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DSM110277_RS09245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DSM110277_RS09245	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DSM110277_RS09250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSM110277_RS09255	COG3852	Histidine kinase
DSM110277_RS09260	COG2204	response regulator
DSM110277_RS09265	COG5000	phosphorelay sensor kinase activity
DSM110277_RS09270	COG2204	response regulator
DSM110277_RS09280	COG0569	domain protein
DSM110277_RS09290	COG1923	regulation of RNA biosynthetic process
DSM110277_RS09295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DSM110277_RS09315	COG2084	Dehydrogenase
DSM110277_RS09335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DSM110277_RS09345	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DSM110277_RS09360	COG3956	TIGRFAM MazG family protein
DSM110277_RS09365	COG1473	amidohydrolase
DSM110277_RS09370	COG0010	Belongs to the arginase family
DSM110277_RS09385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DSM110277_RS09390	COG2890	protein-(glutamine-N5) methyltransferase activity
DSM110277_RS09400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DSM110277_RS09405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DSM110277_RS09410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM110277_RS09415	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DSM110277_RS09430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM110277_RS09440	COG3577	Aspartyl protease
DSM110277_RS09445	COG2095	MarC family integral membrane protein
DSM110277_RS09450	COG0488	(ABC) transporter
DSM110277_RS09455	COG0105	UTP biosynthetic process
DSM110277_RS09490	COG1126	abc transporter atp-binding protein
DSM110277_RS09500	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DSM110277_RS09505	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM110277_RS09520	COG0588	phosphoglycerate mutase activity
DSM110277_RS09545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM110277_RS09545	COG3743	rRNA binding
DSM110277_RS09550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DSM110277_RS09570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DSM110277_RS09575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DSM110277_RS09580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DSM110277_RS09605	COG0052	Belongs to the universal ribosomal protein uS2 family
DSM110277_RS09610	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DSM110277_RS09615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DSM110277_RS09625	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM110277_RS09630	COG0745	RESPONSE REGULATOR receiver
DSM110277_RS09640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DSM110277_RS09650	COG0573	inorganic phosphate transmembrane transporter activity
DSM110277_RS09660	COG5002	protein histidine kinase activity
DSM110277_RS09670	COG0194	GDP metabolic process
DSM110277_RS09675	COG1561	YicC-like family, N-terminal region
DSM110277_RS09685	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DSM110277_RS09695	COG2133	pyrroloquinoline quinone binding
DSM110277_RS09735	COG0433	COG0433 Predicted ATPase
DSM110277_RS09755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM110277_RS09760	COG3267	Type II secretory pathway component ExeA
DSM110277_RS09760	COG3409	Peptidoglycan-binding domain 1 protein
DSM110277_RS09770	COG1238	metal cluster binding
DSM110277_RS09780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSM110277_RS09785	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DSM110277_RS09785	COG3264	Mechanosensitive ion channel
DSM110277_RS09795	COG0494	nUDIX hydrolase
DSM110277_RS09805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSM110277_RS09810	COG0415	Belongs to the DNA photolyase family
DSM110277_RS09815	COG0604	alcohol dehydrogenase
DSM110277_RS09845	COG0114	fumarate hydratase activity
DSM110277_RS09865	COG3588	fructose-bisphosphate aldolase
DSM110277_RS09880	COG0785	Cytochrome C biogenesis protein
DSM110277_RS09885	COG0425	Belongs to the sulfur carrier protein TusA family
DSM110277_RS09890	COG1530	ribonuclease E activity
DSM110277_RS09910	COG0047	phosphoribosylformylglycinamidine synthase activity
DSM110277_RS09915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM110277_RS09920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DSM110277_RS09925	COG0646	methionine synthase
DSM110277_RS09925	COG1410	methionine synthase
DSM110277_RS09935	COG5012	cobalamin binding
DSM110277_RS09945	COG2166	iron-sulfur cluster assembly
DSM110277_RS09955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DSM110277_RS09960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DSM110277_RS09965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DSM110277_RS10250	COG2202	Pas domain
DSM110277_RS10250	COG2205	protein histidine kinase activity
DSM110277_RS10255	COG1012	belongs to the aldehyde dehydrogenase family
DSM110277_RS10265	COG0754	glutathionylspermidine amidase activity
DSM110277_RS10275	COG0702	epimerase
DSM110277_RS10280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DSM110277_RS10285	COG0720	synthase
DSM110277_RS10290	COG0602	queuosine metabolic process
DSM110277_RS10295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DSM110277_RS10300	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110277_RS10315	COG0166	Belongs to the GPI family
DSM110277_RS10320	COG0363	glucosamine-6-phosphate deaminase activity
DSM110277_RS10325	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DSM110277_RS10340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSM110277_RS10350	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DSM110277_RS10355	COG1612	heme a metabolic process
DSM110277_RS10365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DSM110277_RS10365	COG0351	phosphomethylpyrimidine kinase
DSM110277_RS10365	COG0352	thiamine-phosphate diphosphorylase activity
DSM110277_RS10380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DSM110277_RS10380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DSM110277_RS10385	COG2313	pseudouridylate synthase activity
DSM110277_RS10400	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS10405	COG4166	transmembrane transport
DSM110277_RS10430	COG2814	Major facilitator Superfamily
DSM110277_RS10435	COG0513	Belongs to the DEAD box helicase family
DSM110277_RS10450	COG0148	phosphopyruvate hydratase activity
DSM110277_RS10460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DSM110277_RS10465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DSM110277_RS10470	COG0488	(ABC) transporter
DSM110277_RS10490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DSM110277_RS10495	COG0416	fatty acid biosynthetic process
DSM110277_RS10500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM110277_RS10505	COG0776	regulation of translation
DSM110277_RS10520	COG0717	Belongs to the dCTP deaminase family
DSM110277_RS10530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DSM110277_RS10535	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DSM110277_RS10540	COG1472	Belongs to the glycosyl hydrolase 3 family
DSM110277_RS10550	COG0018	arginyl-trna synthetase
DSM110277_RS10555	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DSM110277_RS10560	COG0316	Belongs to the HesB IscA family
DSM110277_RS10600	COG2814	Major facilitator Superfamily
DSM110277_RS10610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM110277_RS10615	COG0215	cysteine-tRNA ligase activity
DSM110277_RS10630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSM110277_RS10645	COG1522	sequence-specific DNA binding
DSM110277_RS10650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM110277_RS10665	COG1278	Cold shock
DSM110277_RS10670	COG0259	pyridoxamine-phosphate oxidase activity
DSM110277_RS10675	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DSM110277_RS10680	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DSM110277_RS10685	COG0436	Aminotransferase
DSM110277_RS10695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DSM110277_RS10715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM110277_RS10720	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DSM110277_RS10725	COG0134	indole-3-glycerol-phosphate synthase activity
DSM110277_RS10730	COG0315	cyclic pyranopterin monophosphate synthase activity
DSM110277_RS10735	COG0303	'Molybdopterin
DSM110277_RS10740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DSM110277_RS10750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM110277_RS10755	COG0372	Belongs to the citrate synthase family
DSM110277_RS10765	COG1024	Enoyl-CoA hydratase
DSM110277_RS10770	COG3088	subunit of a heme lyase
DSM110277_RS10775	COG1138	Cytochrome C-type biogenesis protein
DSM110277_RS10790	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DSM110277_RS10795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DSM110277_RS10800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DSM110277_RS10820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM110277_RS10830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM110277_RS10840	COG0418	dihydroorotase activity
DSM110277_RS10845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DSM110277_RS10850	COG0305	Participates in initiation and elongation during chromosome replication
DSM110277_RS10865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DSM110277_RS10890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DSM110277_RS10905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DSM110277_RS10910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM110277_RS10925	COG0805	protein transport
DSM110277_RS10930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM110277_RS10935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM110277_RS10945	COG3842	ATPase activity
DSM110277_RS10955	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS10970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DSM110277_RS10980	COG0513	Belongs to the DEAD box helicase family
DSM110277_RS10990	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DSM110277_RS11000	COG1007	ATP synthesis coupled electron transport
DSM110277_RS11015	COG0713	ATP synthesis coupled electron transport
DSM110277_RS11030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM110277_RS11035	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DSM110277_RS11075	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM110277_RS11075	COG3743	rRNA binding
DSM110277_RS11085	COG0649	NAD binding
DSM110277_RS11095	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM110277_RS11100	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM110277_RS11110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DSM110277_RS11115	COG1024	Enoyl-CoA hydratase
DSM110277_RS11135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM110277_RS11140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM110277_RS11150	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS11160	COG0346	lactoylglutathione lyase activity
DSM110277_RS11165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM110277_RS11170	COG0546	phosphoglycolate phosphatase activity
DSM110277_RS11175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DSM110277_RS11195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DSM110277_RS11200	COG1519	Transferase
DSM110277_RS11205	COG0438	transferase activity, transferring glycosyl groups
DSM110277_RS11210	COG1473	amidohydrolase
DSM110277_RS11215	COG1473	amidohydrolase
DSM110277_RS11220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110277_RS11225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM110277_RS11230	COG4172	Belongs to the ABC transporter superfamily
DSM110277_RS11240	COG0601	transmembrane transport
DSM110277_RS11245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110277_RS11260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM110277_RS11260	COG3453	Protein conserved in bacteria
DSM110277_RS11265	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DSM110277_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS11295	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DSM110277_RS11310	COG0308	aminopeptidase N
DSM110277_RS11325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DSM110277_RS11330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM110277_RS11350	COG0484	heat shock protein binding
DSM110277_RS11365	COG0006	proline dipeptidase activity
DSM110277_RS11390	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM110277_RS11400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DSM110277_RS11405	COG0849	cell division
DSM110277_RS11410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DSM110277_RS11415	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM110277_RS11420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DSM110277_RS11440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DSM110277_RS11445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DSM110277_RS11460	COG2081	HI0933 family
DSM110277_RS11470	COG2814	Major facilitator Superfamily
DSM110277_RS11475	COG1231	oxidoreductase activity
DSM110277_RS11500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DSM110277_RS11505	COG2066	Belongs to the glutaminase family
DSM110277_RS11510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM110277_RS11520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSM110277_RS11535	COG0275	rRNA processing
DSM110277_RS11540	COG2001	Belongs to the MraZ family
DSM110277_RS11545	COG0489	protein tyrosine kinase activity
DSM110277_RS11560	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DSM110277_RS11565	COG0346	lactoylglutathione lyase activity
DSM110277_RS11575	COG1610	YqeY-like protein
DSM110277_RS11580	COG0505	Belongs to the CarA family
DSM110277_RS11590	COG1802	Transcriptional regulator
DSM110277_RS11600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM110277_RS11610	COG1522	sequence-specific DNA binding
DSM110277_RS11620	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DSM110277_RS11630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSM110277_RS11635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DSM110277_RS11640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DSM110277_RS11650	COG0574	Belongs to the PEP-utilizing enzyme family
DSM110277_RS11650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM110277_RS11655	COG0751	glycine-tRNA ligase activity
DSM110277_RS11665	COG0752	glycyl-tRNA synthetase alpha subunit
DSM110277_RS11680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM110277_RS11690	COG1469	GTP cyclohydrolase I activity
DSM110277_RS11700	COG2917	probably involved in intracellular septation
DSM110277_RS11710	COG0552	protein localization to endoplasmic reticulum
DSM110277_RS11720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DSM110277_RS11725	COG3239	Fatty acid desaturase
DSM110277_RS11735	COG1570	exodeoxyribonuclease VII activity
DSM110277_RS11760	COG1120	ATPase activity
DSM110277_RS11765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM110277_RS11770	COG0628	permease
DSM110277_RS11790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM110277_RS11810	COG0729	surface antigen
DSM110277_RS11835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DSM110277_RS11855	COG0321	lipoyl(octanoyl) transferase activity
DSM110277_RS11890	COG0131	Imidazoleglycerol-phosphate dehydratase
DSM110277_RS11895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DSM110277_RS11910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DSM110277_RS11915	COG0107	imidazoleglycerol-phosphate synthase activity
DSM110277_RS11920	COG0140	phosphoribosyl-ATP diphosphatase activity
DSM110277_RS11925	COG1832	CoA-binding protein
DSM110277_RS11935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSM110277_RS11950	COG2873	o-acetylhomoserine
DSM110277_RS11980	COG1329	Transcriptional regulator
DSM110277_RS11985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DSM110277_RS11990	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DSM110277_RS12010	COG2267	carboxylic ester hydrolase activity
DSM110277_RS12020	COG1793	dna ligase
DSM110277_RS12030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DSM110277_RS12045	COG0564	pseudouridine synthase activity
DSM110277_RS12080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM110277_RS12085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DSM110277_RS12090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM110277_RS12090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM110277_RS12120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM110277_RS12120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM110277_RS12125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DSM110277_RS12130	COG4221	oxidoreductase activity
DSM110277_RS12135	COG0432	Pfam Uncharacterised protein family UPF0047
DSM110277_RS12150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DSM110277_RS12155	COG0358	DNA primase activity
DSM110277_RS12165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DSM110277_RS12200	COG1595	DNA-templated transcription, initiation
DSM110277_RS12225	COG0824	Thioesterase
DSM110277_RS12225	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM110277_RS12235	COG3246	L-lysine catabolic process to acetate
DSM110277_RS12240	COG0667	Aldo Keto reductase
DSM110277_RS12250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM110277_RS12255	COG5002	protein histidine kinase activity
DSM110277_RS12265	COG1522	sequence-specific DNA binding
DSM110277_RS12285	COG0483	inositol monophosphate 1-phosphatase activity
DSM110277_RS12290	COG2130	NADP-dependent
DSM110277_RS12305	COG0583	DNA-binding transcription factor activity
DSM110277_RS12325	COG0525	valine-tRNA ligase activity
DSM110277_RS12335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM110277_RS12350	COG1132	(ABC) transporter
DSM110277_RS12360	COG0354	folic acid binding
DSM110277_RS12365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DSM110277_RS12395	COG3437	response regulator, receiver
DSM110277_RS12395	COG2205	protein histidine kinase activity
DSM110277_RS12395	COG4999	Histidine kinase
DSM110277_RS12395	COG3850	Histidine kinase
DSM110277_RS12525	COG1475	DNA binding
DSM110277_RS12585	COG0582	viral genome integration into host DNA
DSM110277_RS12615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DSM110277_RS12625	COG1454	alcohol dehydrogenase
DSM110277_RS12635	COG0527	aspartate kinase activity
DSM110277_RS12650	COG0725	ABC transporter, periplasmic molybdate-binding protein
DSM110277_RS12655	COG4149	molybdate abc transporter
DSM110277_RS12680	COG0659	secondary active sulfate transmembrane transporter activity
DSM110277_RS12685	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DSM110277_RS12690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DSM110277_RS12730	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DSM110277_RS12735	COG0135	phosphoribosylanthranilate isomerase activity
DSM110277_RS12745	COG0776	regulation of translation
DSM110277_RS12750	COG0539	negative regulation of cytoplasmic translation
DSM110277_RS12760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DSM110277_RS12765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DSM110277_RS12770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DSM110277_RS12775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSM110277_RS12780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DSM110277_RS12785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DSM110277_RS12790	COG1253	flavin adenine dinucleotide binding
DSM110277_RS12795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DSM110277_RS12800	COG1702	phosphate starvation-inducible protein PhoH
DSM110277_RS12815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM110277_RS12830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM110277_RS12835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM110277_RS12840	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DSM110277_RS12850	COG1047	Peptidyl-prolyl cis-trans
DSM110277_RS12870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM110277_RS12895	COG4948	Mandelate Racemase Muconate Lactonizing
DSM110277_RS12900	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS12905	COG0583	DNA-binding transcription factor activity
DSM110277_RS12915	COG0737	Belongs to the 5'-nucleotidase family
DSM110277_RS12935	COG0534	Mate efflux family protein
DSM110277_RS12960	COG2197	response regulator
DSM110277_RS12965	COG0789	Transcriptional regulator
DSM110277_RS12970	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS12980	COG0625	glutathione transferase activity
DSM110277_RS12985	COG0183	Belongs to the thiolase family
DSM110277_RS13005	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110277_RS13025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DSM110277_RS13030	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DSM110277_RS13035	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DSM110277_RS13045	COG0280	phosphate acetyltransferase
DSM110277_RS13045	COG0281	malic enzyme
DSM110277_RS13060	COG3237	CsbD-like
DSM110277_RS13065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DSM110277_RS13070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSM110277_RS13080	COG0596	Alpha beta hydrolase
DSM110277_RS13085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DSM110277_RS13095	COG1435	thymidine kinase activity
DSM110277_RS13105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM110277_RS13125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DSM110277_RS13135	COG1496	oxidoreductase activity
DSM110277_RS13150	COG1522	sequence-specific DNA binding
DSM110277_RS13155	COG0492	ferredoxin-NADP+ reductase activity
DSM110277_RS13160	COG2046	Belongs to the sulfate adenylyltransferase family
DSM110277_RS13160	COG0529	Catalyzes the synthesis of activated sulfate
DSM110277_RS13185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DSM110277_RS13190	COG3454	Phosphonate metabolism
DSM110277_RS13210	COG0459	protein refolding
DSM110277_RS13215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DSM110277_RS13225	COG1227	inorganic diphosphatase activity
DSM110277_RS13245	COG2030	dehydratase
DSM110277_RS13250	COG0196	riboflavin kinase activity
DSM110277_RS13255	COG2983	Belongs to the UPF0260 family
DSM110277_RS13285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DSM110277_RS13290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DSM110277_RS13295	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DSM110277_RS13300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DSM110277_RS13305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM110277_RS13315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM110277_RS13340	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DSM110277_RS13355	COG0287	Prephenate dehydrogenase
DSM110277_RS13360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM110277_RS13365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DSM110277_RS13370	COG0745	RESPONSE REGULATOR receiver
DSM110277_RS13375	COG0519	Catalyzes the synthesis of GMP from XMP
DSM110277_RS13410	COG0142	geranyltranstransferase activity
DSM110277_RS13415	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DSM110277_RS13430	COG0789	Transcriptional regulator
DSM110277_RS13440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSM110277_RS13450	COG0303	'Molybdopterin
DSM110277_RS13500	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS13505	COG0009	L-threonylcarbamoyladenylate synthase
DSM110277_RS13510	COG1678	Uncharacterized ACR, COG1678
DSM110277_RS13520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM110277_RS13530	COG0521	Mo-molybdopterin cofactor biosynthetic process
DSM110277_RS13535	COG1280	lysine exporter protein (LysE YggA)
DSM110277_RS13540	COG1573	uracil-dna glycosylase
DSM110277_RS13545	COG0540	Belongs to the ATCase OTCase family
DSM110277_RS13570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DSM110277_RS13590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DSM110277_RS13595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DSM110277_RS13600	COG2885	chlorophyll binding
DSM110277_RS13610	COG0314	molybdopterin synthase activity
DSM110277_RS13620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DSM110277_RS13625	COG0322	excinuclease ABC activity
DSM110277_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS13645	COG0842	Transport permease protein
DSM110277_RS13650	COG1131	(ABC) transporter
DSM110277_RS13660	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS13660	COG3321	synthase
DSM110277_RS13660	COG0604	alcohol dehydrogenase
DSM110277_RS13670	COG1294	oxidase, subunit
DSM110277_RS13675	COG1271	oxidase subunit
DSM110277_RS13680	COG2205	protein histidine kinase activity
DSM110277_RS13705	COG0174	glutamine synthetase
DSM110277_RS13735	COG0019	diaminopimelate decarboxylase activity
DSM110277_RS13750	COG2205	protein histidine kinase activity
DSM110277_RS13755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM110277_RS13765	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DSM110277_RS13770	COG0594	ribonuclease P activity
DSM110277_RS13775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DSM110277_RS13780	COG0037	tRNA processing
DSM110277_RS13790	COG0706	membrane insertase activity
DSM110277_RS13795	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DSM110277_RS13800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DSM110277_RS13810	COG1126	abc transporter atp-binding protein
DSM110277_RS13815	COG0765	amino acid transport
DSM110277_RS13820	COG4597	amino acid ABC transporter
DSM110277_RS13825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM110277_RS13840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DSM110277_RS13845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DSM110277_RS13850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM110277_RS13855	COG0203	ribosomal protein L17
DSM110277_RS13860	COG0202	RNA polymerase activity
DSM110277_RS13865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DSM110277_RS13870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DSM110277_RS13875	COG0563	adenylate kinase activity
DSM110277_RS13880	COG0201	protein transport
DSM110277_RS13885	COG0200	Binds to the 23S rRNA
DSM110277_RS13890	COG1841	ribosomal large subunit assembly
DSM110277_RS13895	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DSM110277_RS13900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DSM110277_RS13905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DSM110277_RS13910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DSM110277_RS13915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DSM110277_RS13920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DSM110277_RS13925	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DSM110277_RS13930	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DSM110277_RS13935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DSM110277_RS13940	COG0255	Belongs to the universal ribosomal protein uL29 family
DSM110277_RS13960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DSM110277_RS13965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DSM110277_RS13970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DSM110277_RS13975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DSM110277_RS13980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DSM110277_RS13990	COG0089	rRNA binding
DSM110277_RS13995	COG0088	Forms part of the polypeptide exit tunnel
DSM110277_RS14000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DSM110277_RS14005	COG0051	transcription antitermination factor activity, RNA binding
DSM110277_RS14010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DSM110277_RS14015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DSM110277_RS14020	COG0049	tRNA binding
DSM110277_RS14025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DSM110277_RS14035	COG0697	spore germination
DSM110277_RS14040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DSM110277_RS14045	COG0085	RNA polymerase activity
DSM110277_RS14050	COG0222	ribosome binding
DSM110277_RS14055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DSM110277_RS14060	COG0081	regulation of translation
DSM110277_RS14065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DSM110277_RS14070	COG0250	Participates in transcription elongation, termination and antitermination
DSM110277_RS14085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DSM110277_RS14110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSM110277_RS14120	COG0300	oxidoreductase activity
DSM110277_RS14130	COG2096	Adenosyltransferase
DSM110277_RS14150	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM110277_RS14160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM110277_RS14170	COG1660	Displays ATPase and GTPase activities
DSM110277_RS14180	COG2205	protein histidine kinase activity
DSM110277_RS14185	COG0745	RESPONSE REGULATOR receiver
DSM110277_RS14190	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DSM110277_RS14205	COG1396	sequence-specific DNA binding
DSM110277_RS14225	COG1381	Involved in DNA repair and RecF pathway recombination
DSM110277_RS14235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DSM110277_RS14240	COG0571	ribonuclease III activity
DSM110277_RS14245	COG0681	Belongs to the peptidase S26 family
DSM110277_RS14250	COG0736	holo-[acyl-carrier-protein] synthase activity
DSM110277_RS14255	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DSM110277_RS14265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSM110277_RS14270	COG1758	RNA polymerase activity
DSM110277_RS14275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DSM110277_RS14285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DSM110277_RS14295	COG0328	RNA-DNA hybrid ribonuclease activity
DSM110277_RS14300	COG2860	membrane
DSM110277_RS14310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM110277_RS14315	COG0242	peptide deformylase activity
DSM110277_RS14320	COG0242	peptide deformylase activity
DSM110277_RS14325	COG0242	peptide deformylase activity
DSM110277_RS14330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DSM110277_RS14340	COG0435	Glutathione S-transferase
DSM110277_RS14360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DSM110277_RS14365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DSM110277_RS14370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM110277_RS14375	COG0356	it plays a direct role in the translocation of protons across the membrane
DSM110277_RS14400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DSM110277_RS14405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DSM110277_RS14415	COG0228	four-way junction DNA binding
DSM110277_RS14425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DSM110277_RS14430	COG0336	Belongs to the RNA methyltransferase TrmD family
DSM110277_RS14435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DSM110277_RS14440	COG0335	large ribosomal subunit rRNA binding
DSM110277_RS14445	COG0254	rRNA binding
DSM110277_RS14455	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM110277_RS14455	COG0489	protein tyrosine kinase activity
DSM110277_RS14465	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM110277_RS14495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DSM110277_RS14500	COG0181	hydroxymethylbilane synthase activity
DSM110277_RS14505	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DSM110277_RS14510	COG0408	coproporphyrinogen oxidase activity
DSM110277_RS14515	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS14520	COG2813	Specifically methylates the guanine in position
DSM110277_RS14525	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DSM110277_RS14535	COG1686	Belongs to the peptidase S11 family
DSM110277_RS14540	COG4172	Belongs to the ABC transporter superfamily
DSM110277_RS14545	COG4239	(ABC) transporter, permease
DSM110277_RS14550	COG4174	ABC transporter (Permease)
DSM110277_RS14565	COG0077	Prephenate dehydratase
DSM110277_RS14575	COG2816	NAD+ diphosphatase activity
DSM110277_RS14585	COG2321	neutral zinc metallopeptidase
DSM110277_RS14595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DSM110277_RS14605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DSM110277_RS14610	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM110277_RS14640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM110277_RS14650	COG1268	BioY protein
DSM110277_RS14655	COG1492	cobalamin metabolic process
DSM110277_RS14695	COG2099	Precorrin-6x reductase
DSM110277_RS14710	COG2875	Belongs to the precorrin methyltransferase family
DSM110277_RS14715	COG1797	cobyrinic acid a,c-diamide synthase activity
DSM110277_RS14720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DSM110277_RS14720	COG1648	precorrin-2 dehydrogenase activity
DSM110277_RS14740	COG2217	Heavy metal translocating P-type atpase
DSM110277_RS14750	COG1216	Glycosyl transferase, family 2
DSM110277_RS14765	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DSM110277_RS14770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM110277_RS14775	COG1063	alcohol dehydrogenase
DSM110277_RS14780	COG0156	8-amino-7-oxononanoate synthase activity
DSM110277_RS14785	COG1396	sequence-specific DNA binding
DSM110277_RS14795	COG2226	methyltransferase
DSM110277_RS14800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DSM110277_RS14805	COG1024	Enoyl-CoA hydratase
DSM110277_RS14810	COG0268	Binds directly to 16S ribosomal RNA
DSM110277_RS14815	COG1192	Involved in chromosome partitioning
DSM110277_RS14820	COG1475	DNA binding
DSM110277_RS14875	COG3547	Transposase (IS116 IS110 IS902 family)
DSM110277_RS14910	COG1230	cation diffusion facilitator family transporter
DSM110277_RS14940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM110277_RS14965	COG3505	Type IV secretory pathway VirD4
DSM110277_RS14985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DSM110277_RS14990	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DSM110277_RS14995	COG0535	radical SAM domain protein
DSM110277_RS15000	COG0535	radical SAM domain protein
DSM110277_RS15005	COG2205	protein histidine kinase activity
DSM110277_RS15005	COG0784	Response regulator, receiver
DSM110277_RS15005	COG2198	Histidine kinase
DSM110277_RS15095	COG3901	Regulator of nitric oxide reductase transcription
DSM110277_RS15095	COG0348	domain, Protein
DSM110277_RS15100	COG1174	glycine betaine transport
DSM110277_RS15130	COG4962	Type ii secretion system protein e
DSM110277_RS15135	COG2948	multi-organism process
DSM110277_RS15155	COG0741	lytic transglycosylase activity
DSM110277_RS15155	COG1196	nuclear chromosome segregation
DSM110277_RS15155	COG0739	heme binding
DSM110277_RS15180	COG1196	nuclear chromosome segregation
DSM110277_RS15180	COG0741	lytic transglycosylase activity
DSM110277_RS15180	COG0739	heme binding
DSM110277_RS15205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM110277_RS15210	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15220	COG1024	Enoyl-CoA hydratase
DSM110277_RS15225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM110277_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS15245	COG5016	pyruvate
DSM110277_RS15245	COG0511	ligase activity, forming carbon-carbon bonds
DSM110277_RS15260	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DSM110277_RS15265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM110277_RS15295	COG1022	Amp-dependent synthetase and ligase
DSM110277_RS15315	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15320	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15325	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS15330	COG1024	Enoyl-CoA hydratase
DSM110277_RS15345	COG1309	transcriptional regulator
DSM110277_RS15350	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS15380	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM110277_RS15380	COG1902	pentaerythritol trinitrate reductase activity
DSM110277_RS15385	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15400	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DSM110277_RS15405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM110277_RS15420	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS15430	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15435	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
DSM110277_RS15475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110277_RS15480	COG1024	Enoyl-CoA hydratase
DSM110277_RS15490	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110277_RS15535	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15540	COG0183	Belongs to the thiolase family
DSM110277_RS15550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110277_RS15565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DSM110277_RS15595	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15610	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15615	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15645	COG0183	Belongs to the thiolase family
DSM110277_RS15665	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15670	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS15675	COG2030	dehydratase
DSM110277_RS15685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110277_RS15690	COG2030	dehydratase
DSM110277_RS15695	COG0183	Belongs to the thiolase family
DSM110277_RS15710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110277_RS15720	COG1024	Enoyl-CoA hydratase
DSM110277_RS15725	COG1024	Enoyl-CoA hydratase
DSM110277_RS15750	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM110277_RS15770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110277_RS15830	COG1309	transcriptional regulator
DSM110277_RS15835	COG1733	regulation of RNA biosynthetic process
DSM110277_RS15840	COG3384	dioxygenase
DSM110277_RS15910	COG1595	DNA-templated transcription, initiation
DSM110277_RS15930	COG3474	cytochrome
DSM110277_RS15940	COG1595	DNA-templated transcription, initiation
DSM110277_RS15970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DSM110277_RS15995	COG1192	Involved in chromosome partitioning
DSM110277_RS16000	COG1475	DNA binding
DSM110277_RS16005	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM110277_RS16040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSM110277_RS16045	COG2010	Cytochrome c
DSM110277_RS16045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DSM110277_RS16050	COG0531	amino acid
DSM110277_RS16055	COG0586	Pfam SNARE associated Golgi protein
DSM110277_RS16085	COG1285	pathogenesis
DSM110277_RS16095	COG2032	superoxide dismutase activity
DSM110277_RS16105	COG0783	Belongs to the Dps family
DSM110277_RS16115	COG4774	siderophore transport
DSM110277_RS16120	COG2814	Major facilitator Superfamily
DSM110277_RS16155	COG1024	Enoyl-CoA hydratase
DSM110277_RS16170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM110277_RS16175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM110277_RS16205	COG2855	membrane
DSM110277_RS16215	COG2205	protein histidine kinase activity
DSM110277_RS16250	COG1309	transcriptional regulator
DSM110277_RS16275	COG2205	protein histidine kinase activity
DSM110277_RS16285	COG3654	unkown
DSM110277_RS16320	COG3181	Tripartite tricarboxylate transporter family receptor
DSM110277_RS16325	COG0583	DNA-binding transcription factor activity
DSM110277_RS16355	COG2132	Multicopper oxidase
DSM110277_RS16370	COG1629	transport
DSM110277_RS16375	COG3720	iron ion transport
DSM110277_RS16380	COG4558	Periplasmic binding protein
DSM110277_RS16385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM110277_RS16390	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DSM110277_RS16395	COG3920	Histidine kinase
DSM110277_RS16395	COG2202	Pas domain
DSM110277_RS16410	COG1573	uracil-dna glycosylase
DSM110277_RS16435	COG4585	Histidine kinase
DSM110277_RS16450	COG1309	transcriptional regulator
DSM110277_RS16480	COG1609	Transcriptional regulator
DSM110277_RS16495	COG3836	Belongs to the HpcH HpaI aldolase family
DSM110277_RS16500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DSM110277_RS16510	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DSM110277_RS16540	COG2188	Transcriptional regulator
DSM110277_RS16545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSM110277_RS16550	COG0066	3-isopropylmalate dehydratase activity
DSM110277_RS16555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110277_RS16595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM110277_RS16600	COG0183	Belongs to the thiolase family
DSM110277_RS16615	COG4584	PFAM Integrase catalytic
DSM110277_RS16625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DSM110277_RS16630	COG1741	Belongs to the pirin family
DSM110277_RS16655	COG3845	ABC transporter
DSM110277_RS16665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSM110277_RS16685	COG0583	DNA-binding transcription factor activity
DSM110277_RS16705	COG1704	LemA family
DSM110277_RS16720	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS16745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110277_RS16770	COG0183	Belongs to the thiolase family
DSM110277_RS16790	COG0183	Belongs to the thiolase family
DSM110277_RS16795	COG1024	Enoyl-CoA hydratase
DSM110277_RS16800	COG1024	Enoyl-CoA hydratase
DSM110277_RS16820	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110277_RS16835	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS16840	COG1024	Enoyl-CoA hydratase
DSM110277_RS16875	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110277_RS16905	COG4608	Belongs to the ABC transporter superfamily
DSM110277_RS16910	COG0444	Belongs to the ABC transporter superfamily
DSM110277_RS16915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110277_RS16925	COG0747	negative chemotaxis
DSM110277_RS16930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DSM110277_RS16935	COG0251	oxidation-reduction process
DSM110277_RS16940	COG0583	DNA-binding transcription factor activity
DSM110277_RS16945	COG2423	ornithine cyclodeaminase activity
DSM110277_RS16955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110277_RS16970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110277_RS16975	COG0587	DNA-directed DNA polymerase activity
DSM110277_RS17020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM110277_RS17025	COG1473	amidohydrolase
DSM110277_RS17035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110277_RS17040	COG0601	transmembrane transport
DSM110277_RS17045	COG4166	transmembrane transport
DSM110277_RS17060	COG1192	Involved in chromosome partitioning
DSM110277_RS17080	COG0625	glutathione transferase activity
DSM110277_RS17085	COG0300	oxidoreductase activity
DSM110277_RS17090	COG0028	Belongs to the TPP enzyme family
DSM110277_RS17100	COG2124	cytochrome p450
DSM110277_RS17115	COG1012	belongs to the aldehyde dehydrogenase family
DSM110277_RS17120	COG2084	Dehydrogenase
DSM110277_RS17125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110277_RS17140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DSM110277_RS17160	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DSM110277_RS17170	COG4786	Flagellar basal body rod
DSM110277_RS17175	COG4786	Flagellar basal body rod
DSM110277_RS17200	COG0745	RESPONSE REGULATOR receiver
DSM110277_RS17205	COG1706	bacterial-type flagellum-dependent cell motility
DSM110277_RS17220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSM110277_RS17235	COG1558	bacterial-type flagellum-dependent cell motility
DSM110277_RS17240	COG1677	Flagellar hook-basal body complex protein FliE
DSM110277_RS17255	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DSM110277_RS17265	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DSM110277_RS17300	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM110277_RS17305	COG1338	Plays a role in the flagellum-specific transport system
DSM110277_RS17310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM110277_RS17345	COG4957	zinc ion binding
DSM110277_RS17350	COG1360	Flagellar Motor Protein
DSM110277_RS17360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DSM110277_RS17370	COG5002	protein histidine kinase activity
DSM110277_RS17420	COG2017	converts alpha-aldose to the beta-anomer
DSM110277_RS17430	COG2814	Major facilitator Superfamily
DSM110277_RS17440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM110277_RS17465	COG2130	NADP-dependent
DSM110277_RS17470	COG0604	alcohol dehydrogenase
DSM110277_RS17470	COG3321	synthase
DSM110277_RS17470	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS17475	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS17480	COG1960	acyl-CoA dehydrogenase activity
DSM110277_RS17490	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS17495	COG0183	Belongs to the thiolase family
DSM110277_RS17500	COG0588	phosphoglycerate mutase activity
DSM110277_RS17545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM110277_RS17550	COG1946	Acyl-CoA thioesterase
DSM110277_RS17565	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS17570	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS17580	COG1024	Enoyl-CoA hydratase
DSM110277_RS17585	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM110277_RS17585	COG1024	Enoyl-CoA hydratase
DSM110277_RS17590	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110277_RS17645	COG0683	leucine binding
DSM110277_RS17670	COG2814	Major facilitator Superfamily
DSM110277_RS17685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM110277_RS17695	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DSM110277_RS17700	COG0438	transferase activity, transferring glycosyl groups
DSM110277_RS17735	COG0348	domain, Protein
DSM110277_RS17740	COG2010	Cytochrome c
DSM110277_RS17760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM110277_RS17765	COG1312	Catalyzes the dehydration of D-mannonate
DSM110277_RS17770	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM110277_RS17770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110277_RS17790	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110277_RS17800	COG2186	Transcriptional regulator
DSM110277_RS17820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110277_RS17845	COG1595	DNA-templated transcription, initiation
DSM110277_RS17850	COG0745	RESPONSE REGULATOR receiver
DSM110277_RS17855	COG5002	protein histidine kinase activity
DSM110277_RS17860	COG5002	protein histidine kinase activity
DSM110277_RS17875	COG0183	Belongs to the thiolase family
DSM110277_RS17885	COG1192	Involved in chromosome partitioning
DSM110277_RS17895	COG1414	Transcriptional regulator
DSM110277_RS17950	COG3842	ATPase activity
DSM110277_RS17985	COG4584	PFAM Integrase catalytic
DSM110277_RS18045	COG3077	Addiction module antitoxin, RelB DinJ family
DSM110277_RS18160	COG4962	Type ii secretion system protein e
DSM110277_RS18165	COG2948	multi-organism process
DSM110277_RS18185	COG0739	heme binding
DSM110277_RS18185	COG0741	lytic transglycosylase activity
DSM110277_RS18185	COG1196	nuclear chromosome segregation
DSM110277_RS18210	COG0739	heme binding
DSM110277_RS18210	COG0741	lytic transglycosylase activity
DSM110277_RS18210	COG1196	nuclear chromosome segregation
DSM110277_RS18335	COG0785	Cytochrome C biogenesis protein
DSM110277_RS18360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM110277_RS18365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM110277_RS18380	COG2132	Multicopper oxidase
DSM110277_RS18395	COG1230	cation diffusion facilitator family transporter
DSM110277_RS18410	COG0789	Transcriptional regulator
DSM110277_RS18415	COG1999	signal sequence binding
DSM110277_RS18425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DSM110277_RS18425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DSM110277_RS18435	COG1999	signal sequence binding
DSM110277_RS18460	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DSM110277_RS18470	COG2366	antibiotic biosynthetic process
DSM110277_RS18480	COG3034	peptidoglycan biosynthetic process
DSM110277_RS18510	COG1321	iron dependent repressor
DSM110277_RS18515	COG2132	Multicopper oxidase
DSM110277_RS18535	COG1376	ErfK ybiS ycfS ynhG family protein
DSM110277_RS18550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DSM110277_RS18560	COG1192	Involved in chromosome partitioning
DSM110277_RS18565	COG1475	DNA binding
DSM110277_RS18580	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DSM110277_RS18590	COG1091	dTDP-4-dehydrorhamnose reductase activity
DSM110277_RS18610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM110277_RS18620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DSM110277_RS18625	COG0438	transferase activity, transferring glycosyl groups
DSM110277_RS18630	COG0367	asparagine synthase
DSM110277_RS18635	COG0438	transferase activity, transferring glycosyl groups
DSM110277_RS18655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DSM110277_RS18660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM110277_RS18690	COG4584	PFAM Integrase catalytic
DSM110277_RS18710	COG0438	transferase activity, transferring glycosyl groups
DSM110277_RS18730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DSM110277_RS18740	COG0019	diaminopimelate decarboxylase activity
DSM110277_RS18750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM110277_RS18755	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110277_RS18760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110277_RS18765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM110277_RS18775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSM110277_RS18780	COG2135	peptidase activity