locus-tag class description HT745_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HT745_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HT745_RS00055 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HT745_RS00060 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HT745_RS00085 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HT745_RS00095 ENOG4108R7K Metal Dependent Phosphohydrolase HT745_RS00105 ENOG4108UYB regulatoR HT745_RS00110 ENOG4108ZX6 Electron transport protein SCO1 SenC HT745_RS00115 ENOG4105TX3 Histidine kinase HT745_RS00125 ENOG4105K8N protein family UPF0079, ATPase HT745_RS00130 ENOG4105EHM Aminoglycoside phosphotransferase HT745_RS00135 ENOG4108S0S Nucleotidyl transferase HT745_RS00150 ENOG4105K63 Thioredoxin HT745_RS00160 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HT745_RS00170 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HT745_RS00200 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HT745_RS00205 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HT745_RS00210 ENOG4107RZZ dna polymerase iii epsilon subunit HT745_RS00215 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HT745_RS00220 ENOG4105E2X shikimate dehydrogenase HT745_RS00225 ENOG4108UHJ MAF-like protein HT745_RS00230 ENOG4108YXA Membrane HT745_RS00235 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HT745_RS00240 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HT745_RS00245 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HT745_RS00250 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) HT745_RS00265 ENOG4105CSA Coproporphyrinogen iii oxidase HT745_RS00270 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HT745_RS00275 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HT745_RS00280 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HT745_RS00285 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HT745_RS00290 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HT745_RS00295 ENOG4105C6K Malic enzyme HT745_RS00305 ENOG4107R50 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HT745_RS00315 ENOG4105CDH Citrulline--aspartate ligase HT745_RS00320 ENOG4105C7B Threonine dehydratase HT745_RS00325 ENOG4108R85 Short chain dehydrogenase HT745_RS00335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT745_RS00345 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HT745_RS00350 ENOG4105P8F nudix hydrolase HT745_RS00355 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HT745_RS00360 ENOG4105BZ1 (ABC) transporter HT745_RS00365 ENOG4105BZ1 (ABC) transporter HT745_RS00400 ENOG41074H6 response regulator HT745_RS00420 ENOG4105S64 Formate nitrite transporter HT745_RS00440 ENOG4105KNK cytochrome C HT745_RS00450 ENOG4105KXX peptidase s58 dmpa HT745_RS00455 ENOG41082W1 Cupin 2, conserved barrel domain protein HT745_RS00475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS00485 ENOG4105CQB FAD linked oxidase domain protein HT745_RS00490 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS00515 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HT745_RS00520 ENOG4107W7X Aldolase HT745_RS00525 ENOG4105C5I Dehydrogenase HT745_RS00530 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HT745_RS00545 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS00550 ENOG4105F38 ABC transporter, permease HT745_RS00575 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HT745_RS00585 ENOG4105D4A Cell wall formation (By similarity) HT745_RS00590 ENOG4107XKF NMT1 THI5 Like Domain Protein HT745_RS00600 ENOG4105KME endoribonuclease L-psp HT745_RS00605 ENOG4105J0Q Transcriptional regulator HT745_RS00615 ENOG4105DGU Histone deacetylase HT745_RS00630 ENOG4105CFG Acts as a chaperone (By similarity) HT745_RS00635 ENOG4107JPU HT745_RS00645 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HT745_RS00655 ENOG4107QS4 23S rRNA HT745_RS00660 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HT745_RS00680 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HT745_RS00690 ENOG4105MJ2 Competence protein HT745_RS00695 ENOG4105VW4 glutaredoxin 3 HT745_RS00710 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HT745_RS00730 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HT745_RS00745 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HT745_RS00750 ENOG4105M6F mutator MutT protein HT745_RS00755 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HT745_RS00760 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HT745_RS00765 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HT745_RS00790 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HT745_RS00795 ENOG4105CFG Acts as a chaperone (By similarity) HT745_RS00815 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HT745_RS00820 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HT745_RS00830 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HT745_RS00860 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HT745_RS00865 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea HT745_RS00870 ENOG4108IUZ ABC transporter HT745_RS00885 ENOG4105C2X Arabinose 5-phosphate isomerase HT745_RS00890 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HT745_RS00895 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HT745_RS00900 ENOG4105DXM phenylacetic acid degradation protein HT745_RS00905 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HT745_RS00910 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HT745_RS00915 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HT745_RS00920 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HT745_RS00925 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HT745_RS00930 ENOG4105CHU acetyl-coa acetyltransferase HT745_RS00945 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HT745_RS00975 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HT745_RS00985 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HT745_RS00995 ENOG4107RFB Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HT745_RS01020 ENOG4105E3R (LipO)protein HT745_RS01055 ENOG4105ECQ AraC Family Transcriptional Regulator HT745_RS01060 ENOG4105K63 Thioredoxin HT745_RS01075 ENOG4105FYV Amp nucleosidase HT745_RS01080 ENOG4105CPN adenine deaminase HT745_RS01095 ENOG4105ETT transcriptional Regulator, LysR family HT745_RS01105 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS01115 ENOG4105E39 Enoyl-CoA hydratase HT745_RS01135 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HT745_RS01140 ENOG4105CTB Polyprenyl synthetase HT745_RS01145 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HT745_RS01150 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HT745_RS01155 ENOG41090HR transcriptional regulator HT745_RS01160 ENOG4105CM2 brancheD-chain amino acid aminotransferase HT745_RS01170 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HT745_RS01175 ENOG4105DFI Membrane HT745_RS01185 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HT745_RS01195 ENOG4105DP9 ABC transporter HT745_RS01200 ENOG4106SMU thiamine transporter membrane protein HT745_RS01205 ENOG4107T0D ABC, transporter HT745_RS01210 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HT745_RS01225 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HT745_RS01230 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HT745_RS01235 ENOG4105EIX cytochrome c1 HT745_RS01240 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HT745_RS01245 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HT745_RS01270 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HT745_RS01370 ENOG4105C0B DNA polymerase III (alpha subunit) HT745_RS01385 ENOG4105E7W lamb ycsf family protein HT745_RS01400 ENOG4105T0Z Conserved Protein HT745_RS01405 ENOG4105DIQ Transcriptional regulator HT745_RS01450 ENOG4105E9Z Nad-dependent epimerase dehydratase HT745_RS01460 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HT745_RS01465 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HT745_RS01475 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HT745_RS01480 ENOG4105DDW LysR family Transcriptional regulator HT745_RS01505 ENOG4105DHQ Histidine kinase HT745_RS01515 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HT745_RS01520 ENOG4105DWY Agmatine deiminase HT745_RS01525 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HT745_RS01530 ENOG4108M9J MaoC like domain protein HT745_RS01550 ENOG4105DJP Membrane HT745_RS01555 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HT745_RS01570 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HT745_RS01580 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HT745_RS01585 ENOG4105EGS Mechanosensitive ion channel HT745_RS01600 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HT745_RS01610 ENOG4105CQB FAD linked oxidase domain protein HT745_RS01615 ENOG4105EU8 FAD linked oxidase domain protein HT745_RS01625 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HT745_RS01630 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HT745_RS01635 ENOG4108ZNX Heat shock protein HT745_RS01640 ENOG4105BZU Histidine kinase HT745_RS01665 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HT745_RS01670 ENOG4105CCU oxidase (Subunit III) HT745_RS01675 ENOG4105BZ9 Cytochrome C oxidase, subunit I HT745_RS01680 ENOG4105E2S oxidase) subunit II HT745_RS01685 ENOG4105CSH Transporter HT745_RS01690 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HT745_RS01695 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HT745_RS01700 ENOG4105DWF phosphomethylpyrimidine kinase HT745_RS01705 ENOG4107Z6I Thiamine biosynthesis protein HT745_RS01710 ENOG4105ETU transcriptional activator (TenA HT745_RS01715 ENOG4108YI8 ABC transporter HT745_RS01720 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HT745_RS01730 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HT745_RS01735 ENOG4105C09 Bile acid HT745_RS01740 ENOG4105H3G oxidoreductase HT745_RS01750 ENOG4105PGM cation diffusion facilitator family transporter HT745_RS01775 ENOG4108K2P TRANSCRIPTIONal HT745_RS01785 ENOG4105DEF Extracellular solute-binding protein, family 5 HT745_RS01805 ENOG4105CH2 amidohydrolase HT745_RS01860 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS01870 ENOG4105D81 ABC transporter, permease HT745_RS01880 ENOG4105ETT transcriptional Regulator, LysR family HT745_RS01885 ENOG4105ERH Fumarylacetoacetate hydrolase HT745_RS01890 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HT745_RS01895 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS01930 ENOG4107RTG Major Facilitator superfamily HT745_RS01935 ENOG4105E7U AraC family transcriptional regulator HT745_RS01945 ENOG4105RHY Pfam:UPF0157 HT745_RS01955 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HT745_RS01970 ENOG4105C7K acetolactate synthase HT745_RS01975 ENOG4105CJP fad dependent oxidoreductase HT745_RS01980 ENOG4105CDA abc transporter atp-binding protein HT745_RS02000 ENOG4108WYP Transcriptional regulator HT745_RS02030 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS02035 ENOG4108YYH Nadph-dependent fmn reductase HT745_RS02045 ENOG4105C32 Amino acid ABC transporter (Permease) HT745_RS02055 ENOG4105C0Z ABC transporter HT745_RS02060 ENOG4108IV0 ABC, transporter HT745_RS02065 ENOG4105DTD Dehydrogenase HT745_RS02070 ENOG4105CPQ Dehydrogenase HT745_RS02075 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS02085 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HT745_RS02090 ENOG4107XBN GntR Family Transcriptional Regulator HT745_RS02100 ENOG4105DEI Mannitol dehydrogenase HT745_RS02105 ENOG4105CPQ Dehydrogenase HT745_RS02110 ENOG4108XM1 transcriptional regulator AsnC family HT745_RS02120 ENOG4105DEF Extracellular solute-binding protein, family 5 HT745_RS02125 ENOG4105DC7 peptidase M24 HT745_RS02130 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT745_RS02135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS02140 ENOG4105C3U ABC transporter HT745_RS02145 ENOG4108JQ7 (ABC) transporter HT745_RS02150 ENOG4105C26 Dehydrogenase HT745_RS02200 ENOG4105RX8 Protein of unknown function (DUF1523) HT745_RS02210 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HT745_RS02230 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HT745_RS02235 ENOG4105KHC sulfurtransferase HT745_RS02250 ENOG4108YZA Nitrogen regulatory protein pii HT745_RS02255 ENOG4108JQB penicillin-binding protein 1C HT745_RS02265 ENOG410903C (LipO)protein HT745_RS02270 ENOG4108JJ6 Type I secretion system ATPase HT745_RS02280 ENOG4105KME endoribonuclease L-psp HT745_RS02285 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HT745_RS02295 ENOG4105KZX Pterin carbinolamine dehydratase HT745_RS02315 ENOG4106H78 methyltransferase HT745_RS02325 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HT745_RS02330 ENOG4105PW4 Sugar fermentation stimulation protein homolog HT745_RS02335 ENOG4108I62 cina-like protein HT745_RS02350 ENOG4108ZG0 Ompa motb domain protein HT745_RS02355 ENOG4105HEI LysR family (Transcriptional regulator HT745_RS02380 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HT745_RS02385 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HT745_RS02400 ENOG4105CSM endonuclease III HT745_RS02410 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HT745_RS02415 ENOG4105CDV Ompa motb domain protein HT745_RS02425 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HT745_RS02435 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HT745_RS02440 ENOG4108SXK Transporter Drug Metabolite Exporter family HT745_RS02445 ENOG4107SC1 transglycosylase HT745_RS02450 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HT745_RS02460 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HT745_RS02470 ENOG4105DB1 molybdopterin oxidoreductase HT745_RS02475 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HT745_RS02480 ENOG4105HM0 Sulfoacetaldehyde acetyltransferase HT745_RS02485 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HT745_RS02495 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HT745_RS02505 ENOG4108IY8 ABC, transporter HT745_RS02510 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HT745_RS02560 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HT745_RS02570 ENOG4105NI8 Cytosine-specific methyltransferase HT745_RS02590 ENOG4108BUD transposase HT745_RS02615 ENOG4106F59 XRE family Transcriptional regulator HT745_RS02655 ENOG4105DZR Type I site-specific deoxyribonuclease HT745_RS02680 ENOG4108J6E Pfam:Phage_integr_N HT745_RS02725 ENOG4105KK4 UPF0060 membrane protein HT745_RS02730 ENOG4105CI0 Citrate lyase HT745_RS02735 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HT745_RS02745 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS02760 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS02770 ENOG4105RD8 TRAP dicarboxylate transporter HT745_RS02775 ENOG4105F04 LysR family Transcriptional regulator HT745_RS02785 ENOG4105KRQ Addiction module toxin, Txe YoeB family HT745_RS02805 ENOG4108BUD transposase HT745_RS02815 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HT745_RS02820 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HT745_RS02835 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS02855 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HT745_RS02885 ENOG4108WYP Transcriptional regulator HT745_RS02890 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HT745_RS02900 ENOG4105EW9 transcriptional regulator AsnC family HT745_RS02920 ENOG4107S8C mandelate racemase muconate lactonizing HT745_RS02925 ENOG4105F0I Aminotransferase HT745_RS02930 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HT745_RS02950 ENOG4105CA9 Pyruvate kinase HT745_RS02960 ENOG41082BR 50S ribosomal protein L35 HT745_RS02965 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HT745_RS02970 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HT745_RS02975 ENOG4107Z3H Transcriptional regulator, TetR family HT745_RS02980 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HT745_RS02995 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HT745_RS03000 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ HT745_RS03005 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HT745_RS03010 ENOG4105DCF alanine dehydrogenase HT745_RS03015 ENOG4108YXU transcriptional regulator AsnC family HT745_RS03020 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HT745_RS03025 ENOG4105K5G 30S ribosomal protein S21 HT745_RS03040 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HT745_RS03055 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HT745_RS03060 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HT745_RS03065 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HT745_RS03070 ENOG4107QMP dna polymerase iii subunits gamma and tau HT745_RS03080 ENOG4105CGZ zinc metallopeptidase HT745_RS03100 ENOG4105BZU Histidine kinase HT745_RS03110 ENOG4105G9V cytochrome C HT745_RS03115 ENOG4105E43 Extracellular solute-binding protein, family 5 HT745_RS03120 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HT745_RS03125 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HT745_RS03130 ENOG4108JQ5 ABC transporter HT745_RS03145 ENOG410810E transcriptional regulator, lysR family HT745_RS03150 ENOG4105DZ1 carboxypeptidase HT745_RS03160 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HT745_RS03165 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) HT745_RS03170 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HT745_RS03175 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HT745_RS03185 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HT745_RS03190 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HT745_RS03215 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS03225 ENOG4108ES0 acetoacetyl-CoA synthetase HT745_RS03265 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HT745_RS03280 ENOG4107SCK Monooxygenase HT745_RS03300 ENOG4105F1J Homogentisate 1,2-dioxygenase HT745_RS03310 ENOG4105D1F ATP-binding protein HT745_RS03315 ENOG41082FS 50S ribosomal protein L31 HT745_RS03320 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HT745_RS03335 ENOG4108IXY short-chain dehydrogenase reductase HT745_RS03340 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HT745_RS03360 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HT745_RS03375 ENOG4105K5M 30s ribosomal protein S16 HT745_RS03385 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HT745_RS03395 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HT745_RS03420 ENOG4105ETT transcriptional Regulator, LysR family HT745_RS03425 ENOG41081E4 ATP synthase F0 subunit I HT745_RS03430 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HT745_RS03435 ENOG4105VD1 ATP synthase subunit C HT745_RS03440 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HT745_RS03445 ENOG4105N5Q Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HT745_RS03495 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HT745_RS03510 ENOG4105CHF Glutathione S-transferase HT745_RS03525 ENOG4105C87 Aminotransferase class I and II HT745_RS03530 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HT745_RS03535 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HT745_RS03540 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HT745_RS03545 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HT745_RS03555 ENOG4105EN6 Membrane HT745_RS03565 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HT745_RS03585 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HT745_RS03600 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HT745_RS03605 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HT745_RS03615 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HT745_RS03630 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HT745_RS03635 ENOG4105C3F Signal peptidase i HT745_RS03640 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HT745_RS03645 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HT745_RS03655 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) HT745_RS03670 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS03695 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HT745_RS03700 ENOG4105E3W Two component transcriptional regulator (Winged helix family HT745_RS03705 ENOG4105EB3 Histidine kinase HT745_RS03715 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HT745_RS03735 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HT745_RS03750 ENOG4105TPV HT745_RS03755 ENOG4108WBT adenosyltransferase HT745_RS03765 ENOG4105E1F short-chain dehydrogenase reductase HT745_RS03775 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HT745_RS03785 ENOG4105D0M Protease HtpX homolog HT745_RS03790 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HT745_RS03800 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HT745_RS03805 ENOG4108MYF HT745_RS03840 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HT745_RS03845 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HT745_RS03850 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HT745_RS03855 ENOG4108VZM 50s ribosomal protein L10 HT745_RS03860 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HT745_RS03865 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HT745_RS03870 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HT745_RS03895 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HT745_RS03900 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HT745_RS03905 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HT745_RS03910 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HT745_RS03920 ENOG4105CJ3 phosphate transporter HT745_RS03930 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HT745_RS03935 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HT745_RS03940 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HT745_RS03945 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HT745_RS03955 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HT745_RS03960 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HT745_RS03965 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HT745_RS03970 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HT745_RS03975 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HT745_RS03990 ENOG4105CHR reductase HT745_RS03995 ENOG41083MP 50s ribosomal protein l29 HT745_RS04000 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HT745_RS04005 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HT745_RS04010 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HT745_RS04015 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HT745_RS04020 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HT745_RS04025 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HT745_RS04030 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HT745_RS04035 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HT745_RS04040 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HT745_RS04045 ENOG41084HQ 50S ribosomal protein L30 HT745_RS04055 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HT745_RS04060 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HT745_RS04065 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HT745_RS04075 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HT745_RS04080 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HT745_RS04085 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HT745_RS04090 ENOG4108ZT0 50S ribosomal protein l17 HT745_RS04100 ENOG4105C0H protease HT745_RS04105 ENOG4105D1H recombination factor protein RarA HT745_RS04110 ENOG41082CG Protein CrcB homolog HT745_RS04115 ENOG4105EI2 Pseudouridine synthase HT745_RS04120 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HT745_RS04130 ENOG4107QXX ABC transporter HT745_RS04135 ENOG4105EZ7 amino acid ABC transporter HT745_RS04140 ENOG4105DRP amino acid AbC transporter HT745_RS04145 ENOG4105CDA abc transporter atp-binding protein HT745_RS04165 ENOG4105CAS nag kinase HT745_RS04170 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HT745_RS04180 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HT745_RS04185 ENOG4105BZU Histidine kinase HT745_RS04190 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HT745_RS04195 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HT745_RS04200 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HT745_RS04205 ENOG4105VG0 50S ribosomal protein l34 HT745_RS04220 ENOG4105BZU Histidine kinase HT745_RS04270 ENOG4105EAB amino acid AbC transporter HT745_RS04275 ENOG4105E5Q amino acid AbC transporter HT745_RS04280 ENOG4105E5Q amino acid AbC transporter HT745_RS04290 ENOG4108KTG Membrane protein, drug metabolite transporter HT745_RS04295 ENOG4108ZT1 Transcriptional regulator HT745_RS04300 ENOG4105C0R drug resistance transporter emrb qaca subfamily HT745_RS04305 ENOG4105CW7 secretion protein, HlyD family HT745_RS04365 ENOG4105DDR sarcosine oxidase (Beta subunit) HT745_RS04375 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HT745_RS04390 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HT745_RS04395 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT745_RS04405 ENOG4105EMU Dehydrogenase HT745_RS04425 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HT745_RS04430 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HT745_RS04435 ENOG4105E12 capsule polysaccharide HT745_RS04445 ENOG41084CK capsule polysaccharide HT745_RS04460 ENOG4108JQ6 ABC transporter HT745_RS04465 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS04470 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT745_RS04475 ENOG4105DEF Extracellular solute-binding protein, family 5 HT745_RS04480 ENOG4105MP9 class II Aldolase HT745_RS04485 ENOG4105G3Z GntR family transcriptional regulator HT745_RS04495 ENOG4105C8Y Acetylornithine aminotransferase HT745_RS04505 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HT745_RS04510 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HT745_RS04515 ENOG4107XZX Involved in the transcription termination process (By similarity) HT745_RS04525 ENOG4105DFI Membrane HT745_RS04535 ENOG4105DA5 (ABC) transporter HT745_RS04540 ENOG4105E3A (ABC) transporter HT745_RS04565 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HT745_RS04575 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HT745_RS04585 ENOG4108ZAF Molybdopterin HT745_RS04595 ENOG4108ZG0 Ompa motb domain protein HT745_RS04600 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HT745_RS04605 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HT745_RS04640 ENOG4107Y8I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HT745_RS04645 ENOG4105CD3 dihydroorotase HT745_RS04665 ENOG4105CXT aspartate transcarbamylase HT745_RS04670 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HT745_RS04680 ENOG410829K Lysine exporter protein (Lyse ygga) HT745_RS04685 ENOG4108RIR Molybdenum cofactor biosynthesis protein HT745_RS04715 ENOG4108UJU UPF0301 protein HT745_RS04730 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS04745 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HT745_RS04750 ENOG4105CSU acyl-Coa dehydrogenase HT745_RS04790 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HT745_RS04800 ENOG4105CVM Molybdenum cofactor synthesis domain protein HT745_RS04805 ENOG4108Z8I decarboxylase HT745_RS04810 ENOG4105CPC Aldo Keto reductase HT745_RS04815 ENOG4105EQ2 LysR family Transcriptional regulator HT745_RS04825 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HT745_RS04835 ENOG4108Z4X TRANSCRIPTIONal HT745_RS04840 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HT745_RS04850 ENOG4105MHT Transcriptional regulator, ARSR family HT745_RS04860 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HT745_RS04865 ENOG4105EAH synthase HT745_RS04895 ENOG4105CHR reductase HT745_RS04905 ENOG4105CXC rtn protein HT745_RS04910 ENOG4108R3E Dna-3-methyladenine glycosylase i HT745_RS04915 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HT745_RS04920 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HT745_RS04930 ENOG4105CIH Imidazole acetol-phosphate transaminase HT745_RS04945 ENOG4108NH8 Cation transport protein HT745_RS04955 ENOG4105UYK outer membrane protein a HT745_RS04970 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HT745_RS04980 ENOG4105MP9 class II Aldolase HT745_RS04985 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HT745_RS04990 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HT745_RS04995 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HT745_RS05000 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HT745_RS05005 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HT745_RS05035 ENOG4108ZZ3 UPF0260 protein HT745_RS05040 ENOG4105DTN riboflavin biosynthesis protein ribF HT745_RS05045 ENOG4108Z7G MaoC domain protein dehydratase HT745_RS05055 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HT745_RS05075 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HT745_RS05080 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HT745_RS05105 ENOG4105FD8 phosphonate metabolism protein PhnM HT745_RS05110 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HT745_RS05125 ENOG4108ZNX Heat shock protein HT745_RS05140 ENOG4105JAB phenazine biosynthesis protein, phzf family HT745_RS05150 ENOG4107RIQ Sulfate adenylate transferase HT745_RS05160 ENOG4105C3M thioredoxin reductase HT745_RS05165 ENOG4105F7P transcriptional regulator AsnC family HT745_RS05180 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HT745_RS05190 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HT745_RS05205 ENOG4105II7 pyrroline-5-carboxylate reductase HT745_RS05210 ENOG4108Z7R Chaperone CsaA HT745_RS05225 ENOG4107104 thymidine kinase HT745_RS05235 ENOG4105CAU Arsenical resistance protein, ArsH HT745_RS05245 ENOG4105DTI Phosphonopyruvate decarboxylase HT745_RS05260 ENOG4108ZCF integral membrane protein HT745_RS05265 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HT745_RS05270 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HT745_RS05275 ENOG4105EV9 Alpha Beta Hydrolase HT745_RS05290 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HT745_RS05305 ENOG4105VDW Csbd family HT745_RS05310 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HT745_RS05315 ENOG4105C6K Malic enzyme HT745_RS05330 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HT745_RS05335 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HT745_RS05340 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HT745_RS05355 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS05360 ENOG4108EHX EamA-like transporter family HT745_RS05375 ENOG4105ECK Fatty Acid Desaturase HT745_RS05380 ENOG4105D29 Helix-turn-helix type 11 domain protein HT745_RS05400 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HT745_RS05410 ENOG4105CHU acetyl-coa acetyltransferase HT745_RS05415 ENOG4108K3A Glutathione S-transferase HT745_RS05425 ENOG4105CSU acyl-Coa dehydrogenase HT745_RS05440 ENOG4108ZJI phenylacetic acid degradation protein HT745_RS05450 ENOG4107R73 Mate efflux family protein HT745_RS05470 ENOG4105CGH 5'-nucleotidase HT745_RS05480 ENOG4108RAV Conserved protein HT745_RS05490 ENOG4108KSA LysR family transcriptional regulator HT745_RS05495 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS05500 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HT745_RS05505 ENOG4108IGT Dipeptidase HT745_RS05540 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HT745_RS05545 ENOG4105F2Z 3-oxoadipate enol-lactonase HT745_RS05560 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HT745_RS05570 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HT745_RS05575 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HT745_RS05580 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HT745_RS05585 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HT745_RS05590 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HT745_RS05615 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 HT745_RS05625 ENOG4105C9A Phoh family HT745_RS05635 ENOG4107RCQ (CBS) domain HT745_RS05640 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HT745_RS05655 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HT745_RS05660 ENOG4105C26 Dehydrogenase HT745_RS05665 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HT745_RS05675 ENOG4105CAT Cytidine monophosphate kinase HT745_RS05680 ENOG4107SET aldo keto reductase HT745_RS05685 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HT745_RS05690 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HT745_RS05710 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HT745_RS05730 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HT745_RS05735 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HT745_RS05755 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HT745_RS05760 ENOG4105C3G gtp-binding protein HT745_RS05770 ENOG4105DY2 Paraquat-inducible protein b HT745_RS05775 ENOG4105F1S paraquat-inducible protein a HT745_RS05785 ENOG4105BZS acriflavin resistance protein HT745_RS05795 ENOG4105CH5 extracellular solute-binding protein, family 7 HT745_RS05800 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS05810 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS05820 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HT745_RS05825 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase HT745_RS05835 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HT745_RS05840 ENOG4105CGD Nad-dependent epimerase dehydratase HT745_RS05870 ENOG4105BZU Histidine kinase HT745_RS05875 ENOG4105F8C transglutaminase domain-containing protein HT745_RS05880 ENOG4105DIJ Phosphoethanolamine transferase HT745_RS05890 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HT745_RS05905 ENOG4105DHQ Histidine kinase HT745_RS05910 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS05915 ENOG41062JF Transcriptional regulator HT745_RS05920 ENOG4105RD8 TRAP dicarboxylate transporter HT745_RS05930 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS05955 ENOG4105FD8 phosphonate metabolism protein PhnM HT745_RS05965 ENOG4105HRV phosphonate c-p lyase system protein phnl HT745_RS05970 ENOG4105ENV phosphonate C-P lyase system protein PhnK HT745_RS06010 ENOG4105CS9 pantothenic acid kinase HT745_RS06015 ENOG4105C2J ABC transporter HT745_RS06020 ENOG4105CNN ABC, transporter HT745_RS06025 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator HT745_RS06045 ENOG4105CKK Glycosyl transferase, family 2 HT745_RS06075 ENOG4105S7S phosphonate abc transporter HT745_RS06080 ENOG4105EHI Phosphonate ABC transporter, periplasmic HT745_RS06085 ENOG4105D5T phosphonate abc transporter HT745_RS06090 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HT745_RS06105 ENOG4105W39 Membrane HT745_RS06110 ENOG4106J7G oxidoreductase HT745_RS06115 ENOG4108QBF Transcriptional regulator HT745_RS06125 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HT745_RS06130 ENOG4105C5I Dehydrogenase HT745_RS06135 ENOG4105EXW epimerase dehydratase HT745_RS06145 ENOG4105CHR reductase HT745_RS06160 ENOG4108JGH Tetr family transcriptional regulator HT745_RS06170 ENOG4105EMU Dehydrogenase HT745_RS06175 ENOG4105ZXK Dehydrogenase HT745_RS06185 ENOG4105FB2 class II Aldolase HT745_RS06190 ENOG4105CTX dehydratase HT745_RS06195 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HT745_RS06235 ENOG4105DC7 peptidase M24 HT745_RS06250 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HT745_RS06255 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HT745_RS06260 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HT745_RS06265 ENOG4105CQM Urea amidohydrolase subunit alpha HT745_RS06275 ENOG4105KI2 Urea amidohydrolase subunit beta HT745_RS06285 ENOG4108YZ9 Urea amidohydrolase subunit gamma HT745_RS06290 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HT745_RS06300 ENOG4105C32 Amino acid ABC transporter (Permease) HT745_RS06305 ENOG4105CNN ABC, transporter HT745_RS06310 ENOG4105C0Z ABC transporter HT745_RS06315 ENOG4108IV0 ABC, transporter HT745_RS06335 ENOG4105BZ1 (ABC) transporter HT745_RS06340 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS06350 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HT745_RS06355 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) HT745_RS06360 ENOG4105KCV RNA signal recognition particle 4.5S RNA HT745_RS06370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS06390 ENOG4105D1Z hydroxypyruvate reductase HT745_RS06395 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HT745_RS06440 ENOG4105CDW Resistance protein HT745_RS06455 ENOG4105FE9 pseudouridine synthase HT745_RS06460 ENOG4108Z6B deaminase HT745_RS06465 ENOG4107T8T UPF0173 metal-dependent hydrolase HT745_RS06470 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HT745_RS06475 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HT745_RS06485 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HT745_RS06495 ENOG4105MWK D-amino acid dehydrogenase, small subunit HT745_RS06500 ENOG4105W0E 50S ribosomal protein L33 HT745_RS06510 ENOG4105XDF Protein of unknown function (DUF1272) HT745_RS06520 ENOG4105HFZ Membrane HT745_RS06535 ENOG4108WRK Transcriptional regulator HT745_RS06540 ENOG4105ECY inositol monophosphatase HT745_RS06545 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HT745_RS06560 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HT745_RS06580 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HT745_RS06615 ENOG4107E2E PKHD-type hydroxylase HT745_RS06640 ENOG4105D74 hydrolase HT745_RS06705 ENOG4107XDR Lactoylglutathione lyase HT745_RS06720 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HT745_RS06735 ENOG4106A3M Cytochrome p-450 HT745_RS06750 ENOG4105KUZ arsenate reductase HT745_RS06765 ENOG4105E18 UPF0276 protein HT745_RS06775 ENOG4105C22 threonyL-tRNA synthetase HT745_RS06780 ENOG4108RWP Major Facilitator Superfamily protein HT745_RS06825 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class HT745_RS06840 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HT745_RS06845 ENOG4105CJP fad dependent oxidoreductase HT745_RS06850 ENOG4105CFQ glutamine synthetase HT745_RS06855 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HT745_RS06860 ENOG4105CFQ glutamine synthetase HT745_RS06865 ENOG4105DMR ABC, transporter HT745_RS06870 ENOG4105GBT ABC transporter HT745_RS06880 ENOG4108JEH abc transporter atp-binding protein HT745_RS06905 ENOG4105D6S protein involved in catabolism of external DNA HT745_RS06915 ENOG4108KHX Diguanylate cyclase HT745_RS06920 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HT745_RS06950 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HT745_RS06980 ENOG4105EJQ L-serine dehydratase HT745_RS06995 ENOG4105E66 phosphoriboisomerase A HT745_RS07005 ENOG4107QJR hflk protein HT745_RS07010 ENOG4105EPW hflc protein HT745_RS07020 ENOG4105C0H protease HT745_RS07030 ENOG4107Z7P Ferredoxin HT745_RS07040 ENOG4105C12 Phosphoribosylglycinamide synthetase HT745_RS07045 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HT745_RS07065 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HT745_RS07070 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HT745_RS07095 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) HT745_RS07105 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HT745_RS07110 ENOG4105C7K acetolactate synthase HT745_RS07125 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit HT745_RS07140 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HT745_RS07145 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HT745_RS07165 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HT745_RS07185 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HT745_RS07200 ENOG4107THD Involved in phosphonate degradation (By similarity) HT745_RS07215 ENOG4105DRR Transcriptional regulator, GntR family HT745_RS07230 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HT745_RS07235 ENOG4105KTH gatB Yqey HT745_RS07255 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HT745_RS07285 ENOG4108JU3 Alkyl hydroperoxide reductase HT745_RS07290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT745_RS07295 ENOG4105E3W Two component transcriptional regulator (Winged helix family HT745_RS07315 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT745_RS07375 ENOG410903D sensor protein HT745_RS07380 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HT745_RS07385 ENOG4105EHG Permease protein HT745_RS07390 ENOG4107R4I Periplasmic binding protein HT745_RS07395 ENOG4106QJH hemin transport protein HT745_RS07400 ENOG4105X58 receptor HT745_RS07425 ENOG41067XB TonB family HT745_RS07445 ENOG4105DEI Mannitol dehydrogenase HT745_RS07450 ENOG4105CHR reductase HT745_RS07455 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS07475 ENOG4105ETE Transcriptional regulator (LacI family HT745_RS07480 ENOG4105E39 Enoyl-CoA hydratase HT745_RS07485 ENOG4105C0A alcohol dehydrogenase HT745_RS07495 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HT745_RS07505 ENOG4105DTD Dehydrogenase HT745_RS07515 ENOG4105E39 Enoyl-CoA hydratase HT745_RS07545 ENOG4105C32 Amino acid ABC transporter (Permease) HT745_RS07550 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HT745_RS07555 ENOG4105C2J ABC transporter HT745_RS07560 ENOG4108IV0 ABC, transporter HT745_RS07565 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HT745_RS07570 ENOG4105FAV ABC, transporter HT745_RS07575 ENOG4105FDK ABC transporter HT745_RS07595 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HT745_RS07600 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HT745_RS07625 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HT745_RS07630 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HT745_RS07635 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HT745_RS07645 ENOG4108IV0 ABC, transporter HT745_RS07650 ENOG4105C0Z ABC transporter HT745_RS07660 ENOG4105C32 Amino acid ABC transporter (Permease) HT745_RS07670 ENOG4105CFF transcriptional regulator HT745_RS07675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT745_RS07700 ENOG4105KFG YeeE YedE family protein HT745_RS07730 ENOG4106GFD transport protein HT745_RS07750 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HT745_RS07755 ENOG4105EHG Permease protein HT745_RS07765 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HT745_RS07770 ENOG4105Y2X UPF0335 protein HT745_RS07800 ENOG4108UHU Aldolase HT745_RS07805 ENOG4105C01 Dihydroxy-acid dehydratase HT745_RS07830 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HT745_RS07835 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HT745_RS07850 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS07860 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HT745_RS07865 ENOG4105C2C drug resistance transporter, Bcr CflA HT745_RS07870 ENOG4105HF0 Membrane HT745_RS07885 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HT745_RS07890 ENOG4106FI7 cytochrome c-type biogenesis protein HT745_RS07895 ENOG4105DDR sarcosine oxidase (Beta subunit) HT745_RS07910 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HT745_RS07935 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HT745_RS07940 ENOG4105FR1 rard protein HT745_RS07945 ENOG4108URH decarboxylase HT745_RS07955 ENOG4108JJ7 ABC transporter HT745_RS07965 ENOG4105BZS acriflavin resistance protein HT745_RS07980 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HT745_RS07985 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HT745_RS08000 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HT745_RS08005 ENOG4105VIE preprotein translocase, subunit YajC HT745_RS08010 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HT745_RS08015 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HT745_RS08025 ENOG4108UIV Protein of unknown function (DUF498/DUF598) HT745_RS08030 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HT745_RS08035 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HT745_RS08040 ENOG41060IM Heme exporter protein HT745_RS08050 ENOG4107QX9 Thiol disulfide interChange protein HT745_RS08055 ENOG4105CRW Short chain fatty acid transporter HT745_RS08060 ENOG4107QM5 aconitate hydratase HT745_RS08080 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HT745_RS08095 ENOG4105C83 adenylosuccinate lyase HT745_RS08105 ENOG4105VKD bioY protein HT745_RS08150 ENOG4105C5F glutamine synthetase HT745_RS08155 ENOG4108YZA Nitrogen regulatory protein pii HT745_RS08160 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HT745_RS08170 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HT745_RS08215 ENOG4105DY8 decarboxylase HT745_RS08245 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS08250 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HT745_RS08265 ENOG4108Z8I decarboxylase HT745_RS08270 ENOG4105E4C Lytic transglycosylase catalytic HT745_RS08275 ENOG4105CGH 5'-nucleotidase HT745_RS08290 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HT745_RS08295 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HT745_RS08300 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HT745_RS08310 ENOG4108YYC ycei family HT745_RS08315 ENOG4105DS1 cytochrome b561 HT745_RS08320 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HT745_RS08330 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HT745_RS08340 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HT745_RS08345 ENOG4105HHA aminodeoxychorismate lyase HT745_RS08440 ENOG4105D7W serine acetyltransferase HT745_RS08445 ENOG4105C7S Dehydrogenase HT745_RS08450 ENOG4105CPP Dehydrogenase, E1 component HT745_RS08455 ENOG4108JYK Dehydrogenase HT745_RS08465 ENOG4106ABQ septum formation initiator HT745_RS08470 ENOG4105BZA Phosphoglycerate kinase HT745_RS08495 ENOG4105DR5 peptidase HT745_RS08500 ENOG4105ED9 Protein of unknown function (DUF455) HT745_RS08505 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HT745_RS08515 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HT745_RS08520 ENOG4105D2S major facilitator superfamily HT745_RS08530 ENOG4107QN2 dihydrolipoyl dehydrogenase HT745_RS08540 ENOG4106PGW Short-chain dehydrogenase reductase Sdr HT745_RS08545 ENOG4105CHM Aminotransferase HT745_RS08550 ENOG4105C8N cysteinyl-tRNA synthetase HT745_RS08560 ENOG4105D74 hydrolase HT745_RS08570 ENOG4105DXI Major Facilitator superfamily HT745_RS08575 ENOG4108YZG isomerase HT745_RS08580 ENOG4105QUC reductase HT745_RS08605 ENOG4107QWB Ornithine cyclodeaminase HT745_RS08610 ENOG41066UZ arginase EC 3.5.3.1 HT745_RS08625 ENOG4108UM1 dedA family HT745_RS08730 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HT745_RS08730 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HT745_RS08765 ENOG4108IG5 Transcriptional regulator HT745_RS08790 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HT745_RS08815 ENOG4105CAU Arsenical resistance protein, ArsH HT745_RS08825 ENOG4105D6J arsenicaL-resistance protein HT745_RS08860 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HT745_RS08875 ENOG4105RAK Histidine kinase HT745_RS08880 ENOG4108JU6 CBS domain protein HT745_RS08885 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HT745_RS08900 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HT745_RS08905 ENOG4105D49 3-dehydroquinate synthase HT745_RS08910 ENOG4108UUM single-stranded DNA-binding protein HT745_RS08915 ENOG4105E4C Lytic transglycosylase catalytic HT745_RS08930 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS08945 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HT745_RS08950 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HT745_RS08955 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HT745_RS08960 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HT745_RS08970 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HT745_RS08975 ENOG4105DZP Membrane-associated zinc metalloprotease HT745_RS08980 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HT745_RS08990 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HT745_RS08995 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HT745_RS09000 ENOG4105GYT Protein of unknown function (DUF1009) HT745_RS09005 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HT745_RS09010 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HT745_RS09020 ENOG4105EFQ Two component transcriptional regulator (Winged helix family HT745_RS09025 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HT745_RS09030 ENOG4105CB5 ATP-dependent DNA helicase recG HT745_RS09035 ENOG4108NVR Methyl-accepting chemotaxis HT745_RS09045 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HT745_RS09050 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HT745_RS09060 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HT745_RS09065 ENOG4105CGU Enoyl-CoA hydratase HT745_RS09085 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HT745_RS09090 ENOG4108UJD 30S ribosomal protein S9 HT745_RS09105 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HT745_RS09110 ENOG4105CSR polyphosphate kinase 2 HT745_RS09115 ENOG4105EBM Alpha Beta Hydrolase Fold protein HT745_RS09120 ENOG4105CVG Homoserine O-transsuccinylase HT745_RS09140 ENOG4105DJP Membrane HT745_RS09145 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HT745_RS09150 ENOG4105F5V trimethylamine methyltransferase HT745_RS09165 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HT745_RS09170 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HT745_RS09185 ENOG4108UGV hypoxanthine phosphoribosyltransferase HT745_RS09190 ENOG4108Z1B Cyclase dehydrase HT745_RS09200 ENOG4105BZU Histidine kinase HT745_RS09205 ENOG4105CEV competence damage-inducible protein HT745_RS09210 ENOG4108ZAI phosphatidylglycerophosphatase a HT745_RS09215 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HT745_RS09220 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HT745_RS09225 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HT745_RS09230 ENOG4105CUX Signal transduction histidine kinase HT745_RS09240 ENOG4105ES5 Histidine kinase HT745_RS09245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HT745_RS09255 ENOG4105C1A potassium transporter peripheral membrane HT745_RS09260 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HT745_RS09265 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HT745_RS09270 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HT745_RS09275 ENOG4108R99 pseudouridine synthase HT745_RS09285 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HT745_RS09290 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HT745_RS09300 ENOG4105D52 delta-aminolevulinic acid dehydratase HT745_RS09320 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HT745_RS09345 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HT745_RS09355 ENOG4105E43 Extracellular solute-binding protein, family 5 HT745_RS09375 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HT745_RS09395 ENOG4106HMZ Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HT745_RS09405 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HT745_RS09410 ENOG4105CTD carboxy-peptidase HT745_RS09430 ENOG4105P0T Usg family HT745_RS09445 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HT745_RS09450 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) HT745_RS09455 ENOG4107QP8 phosphohexose isomerase HT745_RS09465 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS09485 ENOG4108KU3 Integrase HT745_RS09725 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HT745_RS09735 ENOG4105CYW agmatinase HT745_RS09745 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HT745_RS09760 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HT745_RS09765 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HT745_RS09775 ENOG4105CI3 gtp-binding protein typa HT745_RS09785 ENOG4108XM1 transcriptional regulator AsnC family HT745_RS09820 ENOG4105DHZ alpha beta HT745_RS09825 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HT745_RS09830 ENOG4105C3J Cysteine desulfurase HT745_RS09845 ENOG4105C3K feS assembly ATPase SufC HT745_RS09850 ENOG4105JRK feS assembly protein SufD HT745_RS09865 ENOG4105C9B Cysteine desulfurase HT745_RS09885 ENOG4107XI7 Tetr family transcriptional regulator HT745_RS09890 ENOG4105KJM monovalent cation h antiporter subunit g HT745_RS09895 ENOG4105W4C monovalent cation H antiporter subunit F HT745_RS09905 ENOG4107R4Z monovalent cation h antiporter subunit d HT745_RS09910 ENOG4108ZE9 Monovalent cation H antiporter subunit C HT745_RS09915 ENOG4105D65 subunit l HT745_RS09925 ENOG4105DTQ mandelate racemase muconate lactonizing HT745_RS09930 ENOG4106KNT transcriptional regulator HT745_RS09935 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HT745_RS09945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS09950 ENOG4105C3U ABC transporter HT745_RS09975 ENOG4105BZM domain protein HT745_RS09980 ENOG4105DND Transcriptional regulator HT745_RS09985 ENOG4105D4U had-superfamily hydrolase, subfamily iia HT745_RS09995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS10000 ENOG4105DEF Extracellular solute-binding protein, family 5 HT745_RS10020 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HT745_RS10025 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HT745_RS10045 ENOG4105D7A ATP-binding protein HT745_RS10055 ENOG4105C32 Amino acid ABC transporter (Permease) HT745_RS10060 ENOG4108IV0 ABC, transporter HT745_RS10065 ENOG4105C0Z ABC transporter HT745_RS10075 ENOG4105D8V Glucose sorbosone dehydrogenase HT745_RS10080 ENOG4105ECQ AraC Family Transcriptional Regulator HT745_RS10085 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HT745_RS10095 ENOG4105DSJ YicC domain protein HT745_RS10100 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HT745_RS10105 ENOG4108Z0R Transferase HT745_RS10110 ENOG4105C28 cystathionine HT745_RS10115 ENOG4105BZU Histidine kinase HT745_RS10125 ENOG4105C8U phosphate abc transporter HT745_RS10135 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HT745_RS10145 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT745_RS10165 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS10180 ENOG4105FC8 fad dependent oxidoreductase HT745_RS10195 ENOG4105CH2 amidohydrolase HT745_RS10210 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS10220 ENOG4105F38 ABC transporter, permease HT745_RS10235 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS10275 ENOG4107TPY serine threonine protein kinase HT745_RS10280 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HT745_RS10285 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS10290 ENOG4105E39 Enoyl-CoA hydratase HT745_RS10295 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS10300 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HT745_RS10305 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HT745_RS10315 ENOG4105C29 acyl-CoA thioesterase HT745_RS10320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HT745_RS10335 ENOG4108IV0 ABC, transporter HT745_RS10340 ENOG4105C0Z ABC transporter HT745_RS10350 ENOG4105C32 Amino acid ABC transporter (Permease) HT745_RS10385 ENOG4105CHU acetyl-coa acetyltransferase HT745_RS10390 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HT745_RS10395 ENOG4105CHR reductase HT745_RS10400 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS10405 ENOG4105CC9 acyl-Coa dehydrogenase HT745_RS10415 ENOG4105GCF PGAM HT745_RS10420 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HT745_RS10430 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HT745_RS10435 ENOG4105VJY transcriptional regulator HT745_RS10445 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HT745_RS10450 ENOG4105CE9 30S ribosomal protein S2 HT745_RS10475 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HT745_RS10480 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HT745_RS10485 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HT745_RS10495 ENOG4105K46 50S ribosomal protein l27 HT745_RS10500 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HT745_RS10535 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HT745_RS10540 ENOG4105C9X ppx gppa phosphatase HT745_RS10550 ENOG4105DAE Methylenetetrahydrofolate reductase HT745_RS10570 ENOG4105CBS Chea signal transduction histidine kinase HT745_RS10575 ENOG4108V3W Chemotaxis protein, CheW HT745_RS10580 ENOG4105BZU Histidine kinase HT745_RS10585 ENOG4108VYJ response regulator receiver protein HT745_RS10595 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) HT745_RS10600 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS10610 ENOG4105D38 putrescine abc transporter HT745_RS10620 ENOG4105EFZ amidohydrolase HT745_RS10630 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HT745_RS10635 ENOG4105EGS Mechanosensitive ion channel HT745_RS10645 ENOG41087AY ADP-Ribose pyrophosphatase HT745_RS10655 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HT745_RS10660 ENOG4105CVP deoxyribo-dipyrimidine photolyase HT745_RS10665 ENOG4105C9B Cysteine desulfurase HT745_RS10670 ENOG4105C94 Transporter HT745_RS10675 ENOG4105C94 Transporter HT745_RS10680 ENOG4105K59 histidine triad (HIT) protein HT745_RS10685 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HT745_RS10730 ENOG4105C9Q fumarate hydratase class II HT745_RS10750 ENOG4105WYW fructose-bisphosphate aldolase HT745_RS10765 ENOG4107QIV Cytochrome c biogenesis protein HT745_RS10770 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HT745_RS10775 ENOG4105D2S major facilitator superfamily HT745_RS10780 ENOG4105CHH sulfate transporter HT745_RS10785 ENOG4105C03 ribonuclease HT745_RS10795 ENOG4105CQZ Histidine kinase HT745_RS10800 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HT745_RS10805 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HT745_RS10810 ENOG4107QPR SAICAR synthetase HT745_RS10835 ENOG4108Q52 Methyltransferase cognate corrinoid protein HT745_RS10855 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HT745_RS10865 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HT745_RS10870 ENOG4108V3E phosphoribosylglycinamide formyltransferase HT745_RS10875 ENOG4105CXB phosphoribosylaminoimidazole synthetase HT745_RS10890 ENOG4105E0F Histidine kinase HT745_RS10910 ENOG4105D4P Coproporphyrinogen iii oxidase HT745_RS10915 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HT745_RS10920 ENOG4108RW8 Universal stress protein F HT745_RS10925 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i HT745_RS10940 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) HT745_RS10945 ENOG4105C58 cytochrome c oxidase accessory protein ccog HT745_RS10965 ENOG4105CM2 brancheD-chain amino acid aminotransferase HT745_RS10990 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HT745_RS10995 ENOG4105C5H ABC transporter HT745_RS11000 ENOG41081FY multiple antibiotic resistance (MarC)-related HT745_RS11015 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HT745_RS11030 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HT745_RS11040 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HT745_RS11045 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HT745_RS11055 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HT745_RS11060 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HT745_RS11070 ENOG4105CYW agmatinase HT745_RS11075 ENOG4105CH2 amidohydrolase HT745_RS11080 ENOG4105DXN mazG family HT745_RS11100 ENOG4105CNG UPF0061 protein HT745_RS11110 ENOG4105KVH Transcriptional regulator HT745_RS11115 ENOG4105C5X domain protein HT745_RS11120 ENOG4108NIW Leucine export protein LeuE HT745_RS11125 ENOG4105C1J atp-dependent rna helicase HT745_RS11130 ENOG41090R7 Ferric uptake HT745_RS11145 ENOG4105DFI Membrane HT745_RS11150 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HT745_RS11160 ENOG4105BZU Histidine kinase HT745_RS11165 ENOG4105MWK D-amino acid dehydrogenase, small subunit HT745_RS11175 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HT745_RS11180 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HT745_RS11195 ENOG4105C5H ABC transporter HT745_RS11215 ENOG41082GS 50S ribosomal protein L32 HT745_RS11220 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HT745_RS11225 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HT745_RS11230 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HT745_RS11235 ENOG4105WJX transcriptional regulator MERR family HT745_RS11245 ENOG4105DHP deoxycytidine triphosphate deaminase HT745_RS11255 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HT745_RS11260 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HT745_RS11265 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) HT745_RS11275 ENOG4105C75 arginyL-tRNA synthetase HT745_RS11280 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HT745_RS11285 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HT745_RS11290 ENOG4105CGK Exodeoxyribonuclease III HT745_RS11295 ENOG4105MSY salicylate hydroxylase HT745_RS11310 ENOG4105K5X acetyltransferase HT745_RS11390 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate HT745_RS11395 ENOG4105EA8 2-Nitropropane dioxygenase HT745_RS11400 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS11410 ENOG4105CH5 extracellular solute-binding protein, family 7 HT745_RS11425 ENOG4105C7K acetolactate synthase HT745_RS11430 ENOG4108ZP8 Acetolactate synthase small subunit HT745_RS11445 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HT745_RS11460 ENOG4105DV0 amidase (EC 3.5.1.4 HT745_RS11470 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HT745_RS11480 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HT745_RS11500 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HT745_RS11510 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HT745_RS11520 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HT745_RS11545 ENOG4105EUB pirin domain protein HT745_RS11595 ENOG4105CVJ phosphoglycerate mutase HT745_RS11600 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HT745_RS11605 ENOG4105II7 pyrroline-5-carboxylate reductase HT745_RS11610 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HT745_RS11625 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HT745_RS11630 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HT745_RS11665 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HT745_RS11680 ENOG4105VG1 fes assembly suf system protein HT745_RS11710 ENOG4108Z4V iron-sulfur cluster assembly HT745_RS11720 ENOG4105CP7 Triose-phosphate isomerase HT745_RS11730 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS11735 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ HT745_RS11740 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HT745_RS11745 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HT745_RS11750 ENOG4105CQZ Histidine kinase HT745_RS11755 ENOG4106A3M Cytochrome p-450 HT745_RS11760 ENOG4108XM1 transcriptional regulator AsnC family HT745_RS11775 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HT745_RS11780 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HT745_RS11790 ENOG4105DP0 ferredoxin-NADP reductase HT745_RS11800 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HT745_RS11805 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 HT745_RS11830 ENOG4107XAN XdhC and CoxI family HT745_RS11865 ENOG4105CV1 Transketolase (EC 2.2.1.1) HT745_RS11870 ENOG4105CKW Inner membrane protein yedI HT745_RS11875 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HT745_RS11885 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HT745_RS11900 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HT745_RS11905 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HT745_RS11915 ENOG4105C26 Dehydrogenase HT745_RS11920 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS11945 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HT745_RS11960 ENOG4105KST dependent repressor HT745_RS11965 ENOG4105HA9 of methanol dehydrogenase type HT745_RS11985 ENOG4105K6V RNA polymerase HT745_RS12005 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) HT745_RS12010 ENOG4105F1G UPF0441 protein HT745_RS12015 ENOG4106032 Glutathionylspermidine synthase HT745_RS12020 ENOG4107RTZ reductase HT745_RS12040 ENOG4105VEQ Cold shock protein HT745_RS12045 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HT745_RS12050 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HT745_RS12060 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HT745_RS12075 ENOG4105CRQ synthase (Component I) HT745_RS12090 ENOG4105DDQ anthranilate synthase HT745_RS12095 ENOG4108I0Q anthranilate phosphoribosyltransferase HT745_RS12105 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HT745_RS12110 ENOG4105CVM Molybdenum cofactor synthesis domain protein HT745_RS12115 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HT745_RS12120 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HT745_RS12125 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HT745_RS12130 ENOG4105BZN citrate synthase HT745_RS12140 ENOG4105CGU Enoyl-CoA hydratase HT745_RS12145 ENOG4105KWW Biogenesis protein HT745_RS12150 ENOG4105DA4 cytochrome c-type biogenesis protein HT745_RS12165 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HT745_RS12170 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HT745_RS12175 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HT745_RS12190 ENOG4105ETT transcriptional Regulator, LysR family HT745_RS12200 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HT745_RS12215 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HT745_RS12250 ENOG4105EKE dihydroorotase HT745_RS12255 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HT745_RS12260 ENOG4105CDU Replicative dna helicase HT745_RS12265 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HT745_RS12270 ENOG4105CY3 ABC transporter, permease HT745_RS12275 ENOG4105DHJ ABC, transporter HT745_RS12305 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HT745_RS12325 ENOG4105EMU Dehydrogenase HT745_RS12330 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HT745_RS12335 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HT745_RS12340 ENOG4108K5P (LipO)protein HT745_RS12355 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HT745_RS12360 ENOG41081BE Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HT745_RS12365 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HT745_RS12370 ENOG4105D29 Helix-turn-helix type 11 domain protein HT745_RS12385 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS12390 ENOG4105F1N DNA alkylation repair HT745_RS12395 ENOG4105CHR reductase HT745_RS12405 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HT745_RS12420 ENOG4105C1J atp-dependent rna helicase HT745_RS12425 ENOG4108Z9K Osmotically inducible protein HT745_RS12435 ENOG4107QNB Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HT745_RS12440 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HT745_RS12445 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HT745_RS12450 ENOG4105C8S subunit m HT745_RS12455 ENOG4105D65 subunit l HT745_RS12460 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HT745_RS12465 ENOG4105DF2 NADH dehydrogenase subunit j HT745_RS12470 ENOG4108048 decarboxylase HT745_RS12475 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HT745_RS12480 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HT745_RS12490 ENOG4107R0R NADH dehydrogenase subunit g HT745_RS12510 ENOG4107QIZ NADH dehydrogenase HT745_RS12520 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HT745_RS12525 ENOG4105GKE subunit e HT745_RS12530 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HT745_RS12545 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HT745_RS12555 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HT745_RS12560 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HT745_RS12575 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HT745_RS12590 ENOG4107QX3 carboxylase HT745_RS12615 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS12635 ENOG4105VUF Transcriptional regulator HT745_RS12640 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HT745_RS12650 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HT745_RS12670 ENOG4105KVH Transcriptional regulator HT745_RS12685 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HT745_RS12690 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HT745_RS12700 ENOG4105CH2 amidohydrolase HT745_RS12705 ENOG4105CH2 amidohydrolase HT745_RS12710 ENOG4105MWK D-amino acid dehydrogenase, small subunit HT745_RS12715 ENOG4105CXN decarboxylase HT745_RS12720 ENOG4105CWC Acetylornithine deacetylase HT745_RS12725 ENOG4108JQ6 ABC transporter HT745_RS12740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS12755 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HT745_RS12760 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HT745_RS12765 ENOG4108UK5 Transposase HT745_RS12775 ENOG4107QP3 malate synthase g HT745_RS12785 ENOG4105CD8 aminopeptidase N HT745_RS12790 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HT745_RS12820 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HT745_RS12885 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HT745_RS12890 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HT745_RS12895 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HT745_RS12900 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HT745_RS12905 ENOG4108UFP Essential cell division protein (By similarity) HT745_RS12910 ENOG4105CPF Cell wall formation (By similarity) HT745_RS12915 ENOG4105D4A Cell wall formation (By similarity) HT745_RS12935 ENOG4105DFU Cell wall formation (By similarity) HT745_RS12940 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HT745_RS12955 ENOG4105CBX hi0933 family HT745_RS12960 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HT745_RS12965 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HT745_RS12970 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HT745_RS12975 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HT745_RS12990 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HT745_RS12995 ENOG4107YZH Cell division protein mraZ HT745_RS13020 ENOG4105C4R Atp-dependent dna helicase HT745_RS13025 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HT745_RS13030 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HT745_RS13055 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HT745_RS13060 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HT745_RS13070 ENOG4108T9Y Inner membrane protein ydcZ HT745_RS13075 ENOG4108Z7F N-acetyltransferase HT745_RS13080 ENOG4108JCI Transcriptional regulator HT745_RS13090 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HT745_RS13100 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HT745_RS13105 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase HT745_RS13110 ENOG4105K4P CoA-binding domain protein HT745_RS13185 ENOG4105C8P )-transporter HT745_RS13190 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HT745_RS13195 ENOG4105EW9 transcriptional regulator AsnC family HT745_RS13205 ENOG4105CKD glutathione-regulated potassium-efflux system protein HT745_RS13215 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HT745_RS13220 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HT745_RS13230 ENOG4108VJ1 Transcriptional regulator (CarD family HT745_RS13235 ENOG4108Z4U Ferredoxin HT745_RS13240 ENOG4105VEJ Heat shock protein HT745_RS13270 ENOG4107T0X DNA ligase HT745_RS13285 ENOG4105KSC Transcriptional regulator, TraR DksA family HT745_RS13330 ENOG4105QPS Monooxygenase HT745_RS13350 ENOG4105EUB pirin domain protein HT745_RS13365 ENOG4105EIF outer membrane protein W HT745_RS13370 ENOG4105D6E homoserine dehydrogenase HT745_RS13380 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HT745_RS13390 ENOG4105BZU Histidine kinase HT745_RS13405 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HT745_RS13415 ENOG4105BZU Histidine kinase HT745_RS13460 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HT745_RS13470 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HT745_RS13480 ENOG4105CPC Aldo Keto reductase HT745_RS13490 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HT745_RS13510 ENOG4105DZ1 carboxypeptidase HT745_RS13515 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HT745_RS13520 ENOG4107QRG dna polymerase iii HT745_RS13525 ENOG4105F8V Hydrolase, tatD family HT745_RS13530 ENOG4107YM4 Beta-lactamase domain-containing protein HT745_RS13540 ENOG4107U9T Pfam:Ribonuclease_BN HT745_RS13555 ENOG4105EW9 transcriptional regulator AsnC family HT745_RS13560 ENOG4105C26 Dehydrogenase HT745_RS13580 ENOG4105ECY inositol monophosphatase HT745_RS13585 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HT745_RS13595 ENOG4105DZ2 Transcriptional regulator HT745_RS13600 ENOG4105SYT Methylenetetrahydrofolate reductase HT745_RS13620 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HT745_RS13635 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HT745_RS13650 ENOG4107QI1 Mate efflux family protein HT745_RS13665 ENOG4105DFD Na H antiporter HT745_RS13675 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HT745_RS13690 ENOG4105C02 permease HT745_RS13700 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HT745_RS13705 ENOG4107R33 ppx gppa phosphatase HT745_RS13790 ENOG4105CFF transcriptional regulator HT745_RS13815 ENOG4105CBG Sulfatase HT745_RS13820 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HT745_RS13845 ENOG4105CDY transcriptional regulatory protein HT745_RS13865 ENOG4105NXH GreA GreB family elongation factor HT745_RS13870 ENOG4105DSF transport protein HT745_RS13880 ENOG4105D48 metallophosphoesterase HT745_RS13885 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HT745_RS13890 ENOG4105CJW magnesium transporter HT745_RS13895 ENOG4107QUY Guanine deaminase HT745_RS13910 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HT745_RS13920 ENOG4105CIH Imidazole acetol-phosphate transaminase HT745_RS13930 ENOG4105C5R Aminotransferase HT745_RS13935 ENOG4105BZ1 (ABC) transporter HT745_RS13945 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HT745_RS13950 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HT745_RS13960 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HT745_RS13975 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HT745_RS14040 ENOG4105E4C Lytic transglycosylase catalytic HT745_RS14055 ENOG4105EJX conjugal transfer ATPase HT745_RS14060 ENOG4105E4C Lytic transglycosylase catalytic HT745_RS14120 ENOG4105CJB Exodeoxyribonuclease I HT745_RS14145 ENOG4107T5V SNARE associated Golgi HT745_RS14160 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HT745_RS14165 ENOG4108RTU Aldolase HT745_RS14170 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HT745_RS14175 ENOG4105FGE Short-chain dehydrogenase reductase Sdr HT745_RS14180 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HT745_RS14185 ENOG4105CFH Aspartokinase HT745_RS14205 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HT745_RS14210 ENOG4105E0C molybdate abc transporter HT745_RS14215 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HT745_RS14240 ENOG4105CHH sulfate transporter HT745_RS14245 ENOG410903D sensor protein HT745_RS14250 ENOG4108VWS Yaeq family HT745_RS14255 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HT745_RS14270 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HT745_RS14295 ENOG4105D98 threonine synthase HT745_RS14300 ENOG4108R6F Surfeit locus 1 family protein HT745_RS14305 ENOG4107QS1 Cytochrome C Oxidase, Subunit III HT745_RS14310 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) HT745_RS14320 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HT745_RS14325 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HT745_RS14330 ENOG4105D1U peptidase U62 modulator of DNA gyrase HT745_RS14335 ENOG4105C79 DNA protecting protein DprA HT745_RS14350 ENOG4107QNJ CoA-transferase subunit B HT745_RS14380 ENOG4105CDV Ompa motb domain protein HT745_RS14425 ENOG4107QRT dEAD DEAH box helicase HT745_RS14440 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HT745_RS14445 ENOG4105CKU formyltetrahydrofolate synthetase HT745_RS14450 ENOG4108VNY MOSC domain protein HT745_RS14455 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HT745_RS14460 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HT745_RS14465 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HT745_RS14475 ENOG4105KCK Peptidoglycan-associated lipoprotein HT745_RS14480 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HT745_RS14495 ENOG4105E02 MotA TolQ exbB proton channel HT745_RS14500 ENOG4105WGP Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis (By similarity) HT745_RS14510 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HT745_RS14515 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HT745_RS14545 ENOG4105C25 Primosomal protein n' HT745_RS14550 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HT745_RS14565 ENOG4105VE1 Phosphatidylcholine synthase HT745_RS14570 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HT745_RS14575 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HT745_RS14580 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HT745_RS14590 ENOG4106K28 UPF0283 membrane protein HT745_RS14600 ENOG4105CM6 amino acid regulated cytosolic protein HT745_RS14605 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HT745_RS14620 ENOG4105E0X reductase HT745_RS14645 ENOG4105CGP Urocanate hydratase HT745_RS14655 ENOG4105C84 Histidine ammonia-lyase HT745_RS14660 ENOG4105CI2 imidazolone-5-propionate hydrolase HT745_RS14700 ENOG4105S7S phosphonate abc transporter HT745_RS14715 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HT745_RS14720 ENOG4105BZU Histidine kinase HT745_RS14735 ENOG4105CHU acetyl-coa acetyltransferase HT745_RS14740 ENOG4107HP6 Transcriptional regulator HT745_RS14745 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HT745_RS14750 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ HT745_RS14755 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS14770 ENOG4107QPD alcohol dehydrogenase HT745_RS14775 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HT745_RS14820 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HT745_RS14825 ENOG4107SPB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HT745_RS14830 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HT745_RS14835 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HT745_RS14840 ENOG4105ERH Fumarylacetoacetate hydrolase HT745_RS14845 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HT745_RS14850 ENOG4108SXK Transporter Drug Metabolite Exporter family HT745_RS14860 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS14870 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HT745_RS14875 ENOG4105DRR Transcriptional regulator, GntR family HT745_RS14925 ENOG4105C0I Conserved Protein HT745_RS14935 ENOG4107SDU Methyl-accepting chemotaxis HT745_RS14955 ENOG4105DEF Extracellular solute-binding protein, family 5 HT745_RS14960 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT745_RS14965 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS14970 ENOG4105C3U ABC transporter HT745_RS14975 ENOG4108JQ7 (ABC) transporter HT745_RS14980 ENOG4107XWI flavin reductase domain protein, FMN-binding HT745_RS14985 ENOG410633P Hydantoin racemase HT745_RS14995 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HT745_RS15010 ENOG4105C03 ribonuclease HT745_RS15015 ENOG4108Z03 MAF-like protein HT745_RS15025 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HT745_RS15030 ENOG410811B TRANSCRIPTIONal HT745_RS15035 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HT745_RS15050 ENOG4105KDC 50s ribosomal protein l28 HT745_RS15055 ENOG4105DJT lAO AO transport system ATPase HT745_RS15060 ENOG4105CQ7 ATP-dependent helicase HT745_RS15065 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HT745_RS15080 ENOG4105C8Y Acetylornithine aminotransferase HT745_RS15115 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HT745_RS15130 ENOG4105DJ9 glucan biosynthesis protein HT745_RS15135 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HT745_RS15160 ENOG4108RG0 uracil-dna glycosylase HT745_RS15180 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HT745_RS15190 ENOG4105ECX polysaccharide export HT745_RS15195 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HT745_RS15205 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HT745_RS15220 ENOG4108UT2 hemolysin iii HT745_RS15240 ENOG4105CM2 brancheD-chain amino acid aminotransferase HT745_RS15260 ENOG41083MR nifu domain-containing protein HT745_RS15265 ENOG41072GX Peptidase M22 Glycoprotease HT745_RS15275 ENOG4105DIH basic membrane HT745_RS15280 ENOG4108JQ9 ABC transporter HT745_RS15285 ENOG4105UIB (ABC) transporter HT745_RS15305 ENOG4107SID ATP-dependent exodnase (exonuclease v) HT745_RS15310 ENOG4105NNS Autoinducer synthesis protein HT745_RS15325 ENOG4105E55 glycerol-3-phosphate acyltransferase HT745_RS15335 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HT745_RS15340 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HT745_RS15350 ENOG4105E33 succinate dehydrogenase HT745_RS15365 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HT745_RS15375 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) HT745_RS15380 ENOG4105DJG MaoC domain protein dehydratase HT745_RS15410 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HT745_RS15420 ENOG4105CMV Succinyl-CoA synthetase subunit beta HT745_RS15450 ENOG4105C7S Dehydrogenase HT745_RS15465 ENOG4107QN2 dihydrolipoyl dehydrogenase HT745_RS15485 ENOG4105CAK Cell division ATP-binding protein ftsE HT745_RS15500 ENOG4107RRE RNA-directed DNA polymerase HT745_RS15530 ENOG4105CH7 arginosuccinase HT745_RS15535 ENOG4107ZT5 Thiol disulfide interchange protein HT745_RS15560 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HT745_RS15595 ENOG4105E9K Isocitrate dehydrogenase HT745_RS15600 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HT745_RS15610 ENOG4105EHG Permease protein HT745_RS15615 ENOG4105E0A ABC, transporter HT745_RS15635 ENOG4105DVW rieske (2Fe-2S) HT745_RS15710 ENOG4105JEU Glycosyl transferase, family 2 HT745_RS15715 ENOG4105PSV Polysaccharide Biosynthesis Protein HT745_RS15725 ENOG4105BZU Histidine kinase HT745_RS15740 ENOG4105D3Q Sugar transferase HT745_RS15745 ENOG4105WH1 Two component transcriptional regulator luxr family HT745_RS15785 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HT745_RS15790 ENOG4107QMS site-determining protein HT745_RS15835 ENOG4108S2Y peptide Chain Release factor HT745_RS15850 ENOG4105CHR reductase HT745_RS15855 ENOG4105CT3 Monooxygenase HT745_RS15860 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HT745_RS15865 ENOG4108U78 Glutathione S-transferase HT745_RS15890 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT745_RS15900 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HT745_RS15910 ENOG4105CUT histidyl-tRNA synthetase HT745_RS15935 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HT745_RS15945 ENOG4108JQ9 ABC transporter HT745_RS15950 ENOG4105UIB (ABC) transporter HT745_RS15965 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase HT745_RS15985 ENOG4105CPC Aldo Keto reductase HT745_RS15990 ENOG4105FC8 fad dependent oxidoreductase HT745_RS16005 ENOG4105CQB FAD linked oxidase domain protein HT745_RS16025 ENOG4105NI3 Protein of unknown function (DUF3237) HT745_RS16040 ENOG4105C0W non-ribosomal peptide synthetase HT745_RS16045 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS16055 ENOG4105RD8 TRAP dicarboxylate transporter HT745_RS16060 ENOG4105E9F Enoyl-CoA hydratase HT745_RS16080 ENOG41061H0 Monooxygenase HT745_RS16085 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HT745_RS16100 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HT745_RS16110 ENOG4105C2C drug resistance transporter, Bcr CflA HT745_RS16115 ENOG4105BZU Histidine kinase HT745_RS16130 ENOG4105CPQ Dehydrogenase HT745_RS16135 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HT745_RS16150 ENOG4105C26 Dehydrogenase HT745_RS16165 ENOG4105ERH Fumarylacetoacetate hydrolase HT745_RS16180 ENOG4105C2J ABC transporter HT745_RS16185 ENOG4108HWW ABC transporter HT745_RS16190 ENOG4105DFW ABC transporter HT745_RS16210 ENOG4105CMG Carbohydrate kinase HT745_RS16215 ENOG4105C1B dTDP-glucose 4-6-dehydratase HT745_RS16220 ENOG4105DJV ribulose-phosphate 3-epimerase HT745_RS16230 ENOG4108UKI Enoyl-CoA hydratase HT745_RS16240 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS16245 ENOG4105CC9 acyl-Coa dehydrogenase HT745_RS16250 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HT745_RS16270 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT745_RS16275 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS16280 ENOG4105C1J atp-dependent rna helicase HT745_RS16290 ENOG4105D8X mechanosensitive ion channel HT745_RS16295 ENOG4107QQG Dehydrogenase HT745_RS16305 ENOG4107T8Q Glycosyl transferase (Group 1 HT745_RS16345 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HT745_RS16375 ENOG4108ZTZ UPF0262 protein HT745_RS16385 ENOG4105EQK -acetyltransferase HT745_RS16395 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HT745_RS16430 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HT745_RS16435 ENOG4108IYU L-aspartate oxidase HT745_RS16440 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HT745_RS16445 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HT745_RS16450 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HT745_RS16460 ENOG4105CFU surface antigen HT745_RS16475 ENOG4105DEN Luciferase family HT745_RS16480 ENOG4105QNJ serralysin (EC 3.4.24.40) HT745_RS16485 ENOG4108TXN phosphonate metabolism protein HT745_RS16490 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HT745_RS16515 ENOG4105BZU Histidine kinase HT745_RS16540 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) HT745_RS16550 ENOG4105BZU Histidine kinase HT745_RS16565 ENOG4107TRE AP endonuclease, family 2 HT745_RS16570 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HT745_RS16575 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HT745_RS16580 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS16590 ENOG4108JQ7 (ABC) transporter HT745_RS16600 ENOG4107RRN ABC transporter substrate-binding protein HT745_RS16630 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HT745_RS16660 ENOG41082AG Plasmid maintenance system antidote protein HT745_RS16665 ENOG4105D85 methylase HT745_RS16680 ENOG4105F6A helicase HT745_RS16685 ENOG4105ECI YeeC-like protein HT745_RS16710 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HT745_RS16730 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HT745_RS16740 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT745_RS16760 ENOG4105BZ7 extracellular solute-binding protein family 1 HT745_RS16775 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HT745_RS16785 ENOG4107QZ7 Cellulose synthase catalytic subunit HT745_RS16810 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HT745_RS16835 ENOG4105DDI hemolysin-type calcium-binding region HT745_RS16845 ENOG4105DK7 lysyl-tRNA synthetase HT745_RS16865 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HT745_RS16880 ENOG4105C5H ABC transporter HT745_RS16885 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HT745_RS16905 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HT745_RS16910 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HT745_RS16920 ENOG4105CD3 dihydroorotase HT745_RS16930 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HT745_RS16935 ENOG4108R86 Transcriptional regulator HT745_RS16940 ENOG4107SJI Dehydrogenase HT745_RS16945 ENOG4105BZ8 glutamate synthase HT745_RS16955 ENOG4108UJV acyl-CoA thioesterase i HT745_RS16960 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HT745_RS16970 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HT745_RS16975 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HT745_RS16980 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HT745_RS16990 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HT745_RS17000 ENOG4105C4K Nad synthetase HT745_RS17010 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein HT745_RS17015 ENOG4108RU0 short-chain dehydrogenase reductase HT745_RS17020 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HT745_RS17040 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HT745_RS17055 ENOG4105CNI cell division protein FtsW HT745_RS17060 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HT745_RS17070 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HT745_RS17075 ENOG4105DGW oligopeptidase A HT745_RS17080 ENOG4105D06 uba thif-type nad fad binding protein HT745_RS17085 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HT745_RS17105 ENOG4108YZT Adenosylcobinamide kinase HT745_RS17120 ENOG4105C0P Mg chelatase subunit ChlI HT745_RS17130 ENOG4105D7Z glutathione synthase HT745_RS17135 ENOG41082D8 UPF0102 protein HT745_RS17140 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HT745_RS17150 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HT745_RS17155 ENOG4105CH2 amidohydrolase HT745_RS17170 ENOG4105C31 Tryptophanyl-tRNA synthetase HT745_RS17175 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HT745_RS17180 ENOG4105DGU Histone deacetylase HT745_RS17185 ENOG41069NU Nitroreductase HT745_RS17205 ENOG4105EEX Two component transcriptional regulator (Winged helix family HT745_RS17225 ENOG4105C9M aspartyl-trna synthetase HT745_RS17230 ENOG4105CVE Lytic murein transglycosylase HT745_RS17245 ENOG4105C5F glutamine synthetase HT745_RS17250 ENOG4105CH5 extracellular solute-binding protein, family 7 HT745_RS17255 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS17270 ENOG4106KNT transcriptional regulator HT745_RS17280 ENOG4105C3Q Glycosyl transferase, family 2 HT745_RS17290 ENOG4105CJP fad dependent oxidoreductase HT745_RS17295 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS17325 ENOG4108JQ6 ABC transporter HT745_RS17330 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HT745_RS17335 ENOG4107QYG anthranilate phosphoribosyltransferase HT745_RS17350 ENOG4108IFG nitrite reductase, (NAD(P)H) HT745_RS17355 ENOG4105D7T ABC transporter HT745_RS17385 ENOG4105F27 Major Facilitator HT745_RS17390 ENOG4105HEI LysR family (Transcriptional regulator HT745_RS17395 ENOG4105ETT transcriptional Regulator, LysR family HT745_RS17405 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HT745_RS17425 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HT745_RS17465 ENOG4105D75 Capsular exopolysaccharide family HT745_RS17470 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HT745_RS17480 ENOG4105W8Z 4'-phosphopantetheinyl transferase HT745_RS17495 ENOG4105D3Q Sugar transferase HT745_RS17515 ENOG4105CPQ Dehydrogenase HT745_RS17520 ENOG4108K3A Glutathione S-transferase HT745_RS17530 ENOG4105ERH Fumarylacetoacetate hydrolase HT745_RS17540 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HT745_RS17545 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS17555 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HT745_RS17560 ENOG4105Q56 cytochrome P450 HT745_RS17570 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HT745_RS17575 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HT745_RS17580 ENOG4107YCY Transcriptional regulator HT745_RS17595 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS17600 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HT745_RS17605 ENOG4108IPT Naphthoate synthase HT745_RS17610 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS17615 ENOG4105H1G trap transporter solute receptor taxi family HT745_RS17670 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HT745_RS17680 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HT745_RS17685 ENOG4105CBC glutamate synthase HT745_RS17690 ENOG4107MV2 Inherit from COG: Hemolysin-type calcium-binding HT745_RS17700 ENOG41066U0 HT745_RS17705 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HT745_RS17710 ENOG4105ECR NmrA family HT745_RS17715 ENOG4105KVH Transcriptional regulator HT745_RS17720 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HT745_RS17735 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HT745_RS17745 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HT745_RS17765 ENOG4105YK5 50S ribosomal protein L36 HT745_RS17775 ENOG4105CYM Glutathione S-transferase HT745_RS17780 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component HT745_RS17800 ENOG4108IV0 ABC, transporter HT745_RS17815 ENOG4105C32 Amino acid ABC transporter (Permease) HT745_RS17820 ENOG4105C0Z ABC transporter HT745_RS17825 ENOG4108IQE Amp-dependent synthetase and ligase HT745_RS17840 ENOG4105BZU Histidine kinase HT745_RS17845 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HT745_RS17855 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HT745_RS17860 ENOG4105F7F Chaperone HT745_RS17870 ENOG4108IEG Formate dehydrogenase Alpha subunit HT745_RS17885 ENOG4108RXX maleylacetoacetate isomerase HT745_RS17890 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HT745_RS17900 ENOG4105C6X Major Facilitator HT745_RS17915 ENOG4105K6V RNA polymerase HT745_RS17920 ENOG4108NIX Factor ChrR HT745_RS17945 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HT745_RS17960 ENOG4107RPQ ABC transporter HT745_RS17965 ENOG4105CC5 ABC transporter HT745_RS17970 ENOG4105DIK (ABC) transporter HT745_RS17975 ENOG4105DSE periplasmic solute binding protein HT745_RS17980 ENOG4107WP9 Histidine kinase HT745_RS17985 ENOG4105E3W Two component transcriptional regulator (Winged helix family HT745_RS17995 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HT745_RS18000 ENOG4105C26 Dehydrogenase HT745_RS18020 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HT745_RS18025 ENOG4105DC1 bifunctional purine biosynthesis protein purh HT745_RS18035 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HT745_RS18045 ENOG4105FQP Beta-lactamase HT745_RS18050 ENOG4105DUM transcriptional regulator, lysR family HT745_RS18055 ENOG4105DXX methyltransferase HT745_RS18065 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HT745_RS18070 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HT745_RS18080 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HT745_RS18095 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HT745_RS18105 ENOG4105BZG amino acid carrier protein HT745_RS18110 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HT745_RS18115 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HT745_RS18130 ENOG4105D3R alkyl hydroperoxide reductase HT745_RS18150 ENOG4105D3G Pseudouridine synthase HT745_RS18195 ENOG4105CHU acetyl-coa acetyltransferase HT745_RS18210 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HT745_RS18225 ENOG4107TMZ Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HT745_RS18240 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HT745_RS18255 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HT745_RS18260 ENOG4105K63 Thioredoxin HT745_RS18265 ENOG4105CGK Exodeoxyribonuclease III HT745_RS18270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT745_RS18275 ENOG4107QJN gtp cyclohydrolase ii HT745_RS18285 ENOG4105DFA alanine racemase domain protein HT745_RS18295 ENOG4105TXM Domain of unknown function (DUF3576) HT745_RS18300 ENOG4105C8T Leucyl-tRNA synthetase HT745_RS18335 ENOG4105E39 Enoyl-CoA hydratase HT745_RS18350 ENOG4105CMS peptidase U62, modulator of DNA gyrase HT745_RS18355 ENOG4105ECY inositol monophosphatase HT745_RS18370 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HT745_RS18390 ENOG4105CEN a g-specific adenine glycosylase HT745_RS18395 ENOG4105EEF Alkane 1-monooxygenase HT745_RS18405 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HT745_RS18410 ENOG4105C26 Dehydrogenase HT745_RS18420 ENOG4105C26 Dehydrogenase HT745_RS18455 ENOG4105MWK D-amino acid dehydrogenase, small subunit HT745_RS18460 ENOG4105EW9 transcriptional regulator AsnC family HT745_RS18470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS18475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT745_RS18490 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HT745_RS18495 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HT745_RS18500 ENOG4108SZE gCN5-related N-acetyltransferase HT745_RS18505 ENOG4105CWC Acetylornithine deacetylase HT745_RS18520 ENOG4105CJP fad dependent oxidoreductase HT745_RS18530 ENOG4105W8I Transcriptional regulator HT745_RS18570 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HT745_RS18580 ENOG41077A9 carbonic anhydrase HT745_RS18590 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HT745_RS18595 ENOG4107SN7 NLP P60 protein HT745_RS18605 ENOG4108ZJI phenylacetic acid degradation protein HT745_RS18630 ENOG4105RK9 auxin efflux carrier HT745_RS18635 ENOG4105C4W S-formylglutathione hydrolase HT745_RS18645 ENOG4108UPT UPF0178 protein HT745_RS18655 ENOG4105CIF Ornithine Cyclodeaminase HT745_RS18660 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HT745_RS18665 ENOG4105DCM major facilitator superfamily HT745_RS18670 ENOG4105D6Z AFG1 family ATPase HT745_RS18680 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HT745_RS18685 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HT745_RS18695 ENOG4105BZ1 (ABC) transporter HT745_RS18700 ENOG4105C01 Dihydroxy-acid dehydratase HT745_RS18720 ENOG4105CN1 protease HT745_RS18730 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HT745_RS18750 ENOG4105C2M dna polymerase I HT745_RS18760 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HT745_RS18770 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HT745_RS18790 ENOG4108JQB penicillin-binding protein 1C HT745_RS18795 ENOG4105DN3 alpha-2-macroglobulin domain protein HT745_RS18800 ENOG4105BZU Histidine kinase HT745_RS18805 ENOG4105D1Q UPF0246 protein HT745_RS18815 ENOG4105C9U ATP-dependent DNA helicase RecQ HT745_RS18835 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HT745_RS18855 ENOG4108YZN class I peptide chain release factor HT745_RS18865 ENOG4107RH7 Nicotinate phosphoribosyltransferase HT745_RS18870 ENOG4108RWI nicotinamidase HT745_RS18875 ENOG4108Z9Z response to DNA damage stimulus HT745_RS18880 ENOG4105C72 UPF0176 protein HT745_RS18885 ENOG4105DCM major facilitator superfamily HT745_RS18890 ENOG4105ER2 Ompa motb domain protein HT745_RS18925 ENOG4105C6Y Udp-glucose 6-dehydrogenase HT745_RS18930 ENOG4105CJP fad dependent oxidoreductase HT745_RS18935 ENOG4105D38 putrescine abc transporter HT745_RS18940 ENOG4105F38 ABC transporter, permease HT745_RS18945 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS18960 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HT745_RS18970 ENOG4105ENR peptidase, M24 HT745_RS18975 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS18995 ENOG4105CVE Lytic murein transglycosylase HT745_RS19000 ENOG4105D29 Helix-turn-helix type 11 domain protein HT745_RS19005 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HT745_RS19020 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HT745_RS19035 ENOG4107R0W ABC transporter HT745_RS19050 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HT745_RS19075 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HT745_RS19090 ENOG4105EAC phosphoserine phosphatase HT745_RS19095 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HT745_RS19100 ENOG4108JQ1 Dehydrogenase HT745_RS19115 ENOG4105CPQ Dehydrogenase HT745_RS19120 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HT745_RS19135 ENOG4108JCI Transcriptional regulator HT745_RS19140 ENOG4105CHU acetyl-coa acetyltransferase HT745_RS19145 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HT745_RS19150 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HT745_RS19155 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HT745_RS19165 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HT745_RS19195 ENOG4105EW9 transcriptional regulator AsnC family HT745_RS19200 ENOG4105MWK D-amino acid dehydrogenase, small subunit HT745_RS19205 ENOG4105KME endoribonuclease L-psp HT745_RS19210 ENOG4105DV0 amidase (EC 3.5.1.4 HT745_RS19215 ENOG4105BZC d-serine deaminase HT745_RS19220 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HT745_RS19240 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT745_RS19245 ENOG4105DEF Extracellular solute-binding protein, family 5 HT745_RS19260 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS19265 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HT745_RS19275 ENOG4105BZU Histidine kinase HT745_RS19280 ENOG4105BZU Histidine kinase HT745_RS19285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT745_RS19300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT745_RS19305 ENOG4105E98 transcriptional regulator DeoR family HT745_RS19310 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HT745_RS19325 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HT745_RS19345 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HT745_RS19350 ENOG4108RJS alcohol dehydrogenase HT745_RS19365 ENOG4105BZS acriflavin resistance protein HT745_RS19370 ENOG4105C1P efflux transporter, rnd family, mfp subunit HT745_RS19380 ENOG4106D4I domain protein HT745_RS19385 ENOG4107VRP DNA repair exonuclease HT745_RS19400 ENOG4105BZS acriflavin resistance protein HT745_RS19405 ENOG4105C1P efflux transporter, rnd family, mfp subunit HT745_RS19430 ENOG4105JSC dimethylmenaquinone methyltransferase HT745_RS19435 ENOG4105CH2 amidohydrolase HT745_RS19440 ENOG4105DEF Extracellular solute-binding protein, family 5 HT745_RS19450 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS19470 ENOG4105CJP fad dependent oxidoreductase HT745_RS19475 ENOG4105ECW sulfate abc transporter HT745_RS19480 ENOG4105F38 ABC transporter, permease HT745_RS19490 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS19495 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS19505 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HT745_RS19510 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HT745_RS19520 ENOG4108Z2U ureidoglycolate hydrolase HT745_RS19530 ENOG4105VT2 5-hydroxyisourate hydrolase HT745_RS19540 ENOG4105CC0 LysR family Transcriptional regulator HT745_RS19550 ENOG4105EJC lysr family transcriptional regulator HT745_RS19555 ENOG4107YV9 domain protein HT745_RS19560 ENOG4105C7W Xanthine dehydrogenase HT745_RS19575 ENOG4107QUY Guanine deaminase HT745_RS19580 ENOG4105S0E allantoin catabolism protein HT745_RS19590 ENOG41069M3 Transcriptional regulator HT745_RS19610 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HT745_RS19615 ENOG4108KB2 LysR family Transcriptional regulator HT745_RS19625 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HT745_RS19630 ENOG4106NZI LysR family Transcriptional regulator HT745_RS19635 ENOG4105C01 Dihydroxy-acid dehydratase HT745_RS19640 ENOG4107T5V SNARE associated Golgi HT745_RS19650 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HT745_RS19730 ENOG4108EHY type IV secretion system HT745_RS19735 ENOG4105CMA conjugation trbi family protein HT745_RS19745 ENOG4105PDG Type IV secretion system protein VirB8 HT745_RS19765 ENOG4105E4C Lytic transglycosylase catalytic HT745_RS19825 ENOG4105W1Y Transcriptional regulator HT745_RS19830 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HT745_RS19840 ENOG4105KWW Biogenesis protein HT745_RS19845 ENOG4107QX9 Thiol disulfide interChange protein HT745_RS19850 ENOG4105DA4 cytochrome c-type biogenesis protein HT745_RS19855 ENOG4108ZX6 Electron transport protein SCO1 SenC HT745_RS19895 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HT745_RS19900 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HT745_RS19910 ENOG4105CUJ penicillin amidase HT745_RS19920 ENOG4105KST dependent repressor HT745_RS19945 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HT745_RS19975 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HT745_RS20055 ENOG4105VW4 glutaredoxin 3 HT745_RS20060 ENOG4108M4U conserved membrane protein HT745_RS20065 ENOG4107QIV Cytochrome c biogenesis protein HT745_RS20085 ENOG4107ZT5 Thiol disulfide interchange protein HT745_RS20090 ENOG4107QX9 Thiol disulfide interChange protein HT745_RS20105 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HT745_RS20130 ENOG4105VPX protein, conserved in bacteria HT745_RS20135 ENOG4107Y80 Major Facilitator superfamily HT745_RS20190 ENOG4108JJB ABC transporter HT745_RS20195 ENOG4107YZB Cobalt transport protein HT745_RS20200 ENOG4107ZYJ bioY protein HT745_RS20215 ENOG4107F3J Amp-dependent synthetase and ligase HT745_RS20220 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HT745_RS20225 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HT745_RS20230 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HT745_RS20235 ENOG4108IYU L-aspartate oxidase HT745_RS20240 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HT745_RS20290 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HT745_RS20305 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HT745_RS20365 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS20380 ENOG4105CJP fad dependent oxidoreductase HT745_RS20430 ENOG4105CMA conjugation trbi family protein HT745_RS20450 ENOG4105E4C Lytic transglycosylase catalytic HT745_RS20475 ENOG4105E4C Lytic transglycosylase catalytic HT745_RS20565 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HT745_RS20580 ENOG4105C0K Gdp-mannose 4,6-dehydratase HT745_RS20620 ENOG4108WUH Transcriptional regulator, TetR family HT745_RS20660 ENOG41079YP Citrate utilization protein b HT745_RS20665 ENOG4107EFR Flavocytochrome c HT745_RS20670 ENOG4105DRR Transcriptional regulator, GntR family HT745_RS20680 ENOG4108JQ1 Dehydrogenase HT745_RS20695 ENOG4105C7F AcnD-accessory protein PrpF HT745_RS20715 ENOG4108TAG Histidine kinase HT745_RS20740 ENOG4105CS1 NAD(P)H quinone oxidoreductase HT745_RS20755 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) HT745_RS20760 ENOG4105ETE Transcriptional regulator (LacI family HT745_RS20765 ENOG4105CHR reductase HT745_RS20770 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS20780 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HT745_RS20810 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS20820 ENOG4105E39 Enoyl-CoA hydratase HT745_RS20835 ENOG4105CAF HipA N-terminal domain protein HT745_RS20850 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HT745_RS20855 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HT745_RS20860 ENOG4105C7W Xanthine dehydrogenase HT745_RS20865 ENOG4105E0K tonB-dependent siderophore receptor HT745_RS20870 ENOG4105E0A ABC, transporter HT745_RS20875 ENOG4108IHU transport system permease protein HT745_RS20880 ENOG4105DQ5 transport system permease protein HT745_RS20895 ENOG4105DDW LysR family Transcriptional regulator HT745_RS20910 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HT745_RS20915 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HT745_RS20930 ENOG4105H1G trap transporter solute receptor taxi family HT745_RS20940 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HT745_RS20945 ENOG4107HP6 Transcriptional regulator HT745_RS20950 ENOG4105ECQ AraC Family Transcriptional Regulator HT745_RS20955 ENOG4105DDR sarcosine oxidase (Beta subunit) HT745_RS20960 ENOG4105WIU sarcosine oxidase delta subunit HT745_RS20965 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HT745_RS20990 ENOG4105FA0 parb-like partition protein HT745_RS21010 ENOG41086VY Fic/DOC family HT745_RS21040 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HT745_RS21125 ENOG4105F9F transposase HT745_RS21155 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HT745_RS21170 ENOG4105R8C Transcriptional regulator HT745_RS21200 ENOG4107Y80 Major Facilitator superfamily HT745_RS21205 ENOG4105VPX protein, conserved in bacteria HT745_RS21220 ENOG41080HT Transcriptional regulator, arsr family HT745_RS21250 ENOG4105E3B Multicopper oxidase HT745_RS21265 ENOG4105DHQ Histidine kinase HT745_RS21270 ENOG4105XJC Two component transcriptional regulator (Winged helix family HT745_RS21275 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HT745_RS21280 ENOG4107ZT5 Thiol disulfide interchange protein HT745_RS21285 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HT745_RS21290 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein HT745_RS21315 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HT745_RS21320 ENOG4105KVH Transcriptional regulator HT745_RS21325 ENOG4105R8C Transcriptional regulator HT745_RS21335 ENOG4105ENT Efflux transporter rnd family, mfp subunit HT745_RS21360 ENOG4105K56 Transcriptional regulator HT745_RS21380 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HT745_RS21390 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HT745_RS21395 ENOG4105C0Z ABC transporter HT745_RS21405 ENOG4105C32 Amino acid ABC transporter (Permease) HT745_RS21410 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HT745_RS21415 ENOG4108IV0 ABC, transporter HT745_RS21435 ENOG4108UKI Enoyl-CoA hydratase HT745_RS21445 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HT745_RS21460 ENOG4105CHU acetyl-coa acetyltransferase HT745_RS21480 ENOG4108ZMQ domain protein HT745_RS21485 ENOG4105D2B acyl-CoA dehydrogenase HT745_RS21490 ENOG4105CC9 acyl-Coa dehydrogenase HT745_RS21510 ENOG4105CHU acetyl-coa acetyltransferase HT745_RS21520 ENOG4105CHR reductase HT745_RS21540 ENOG4105D2B acyl-CoA dehydrogenase HT745_RS21545 ENOG4108KC2 acyl-Coa dehydrogenase HT745_RS21560 ENOG4105X7H acyl-CoA dehydrogenase HT745_RS21565 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS21610 ENOG4105CHU acetyl-coa acetyltransferase HT745_RS21615 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS21635 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HT745_RS21660 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS21670 ENOG4105E39 Enoyl-CoA hydratase HT745_RS21675 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HT745_RS21680 ENOG4105CHR reductase HT745_RS21685 ENOG4108IV0 ABC, transporter HT745_RS21695 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HT745_RS21700 ENOG4105C32 Amino acid ABC transporter (Permease) HT745_RS21710 ENOG4105C0Z ABC transporter HT745_RS21715 ENOG4108M9J MaoC like domain protein HT745_RS21720 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS21730 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HT745_RS21735 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HT745_RS21745 ENOG4107QX3 carboxylase HT745_RS21750 ENOG4105DZS Phenylacetate-CoA ligase HT745_RS21765 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS21770 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HT745_RS21775 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS21800 ENOG4105CHR reductase HT745_RS21805 ENOG4105R8C Transcriptional regulator HT745_RS21820 ENOG4105E39 Enoyl-CoA hydratase HT745_RS21825 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HT745_RS21830 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS21835 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS21850 ENOG4107QSA Oxaloacetate decarboxylase HT745_RS21870 ENOG4107QX3 carboxylase HT745_RS21875 ENOG4105E39 Enoyl-CoA hydratase HT745_RS21885 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS21890 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HT745_RS21895 ENOG4105F9F transposase HT745_RS21920 ENOG4105E4C Lytic transglycosylase catalytic HT745_RS21945 ENOG4105E4C Lytic transglycosylase catalytic HT745_RS21965 ENOG4105CMA conjugation trbi family protein HT745_RS22040 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HT745_RS22080 ENOG41082YX Transcriptional regulator, arsr family HT745_RS22085 ENOG4107S21 permease HT745_RS22115 ENOG4105CVM Molybdenum cofactor synthesis domain protein HT745_RS22140 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HT745_RS22145 ENOG4105BZU Histidine kinase HT745_RS22160 ENOG4105D6J arsenicaL-resistance protein HT745_RS22170 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HT745_RS22235 ENOG4108J6E Pfam:Phage_integr_N HT745_RS22255 ENOG4105KRQ Addiction module toxin, Txe YoeB family HT745_RS22270 ENOG4105C79 DNA protecting protein DprA HT745_RS22280 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HT745_RS22325 ENOG41068WC Domain of unknown function (DUF955) HT745_RS22385 ENOG4108IV0 ABC, transporter HT745_RS22390 ENOG4105C32 Amino acid ABC transporter (Permease) HT745_RS22405 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HT745_RS22430 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HT745_RS22435 ENOG4107S2E monooxygenase HT745_RS22440 ENOG4108VQN 4-hydroxyphenylacetate 3-monooxygenase reductase HT745_RS22450 ENOG4105HEI LysR family (Transcriptional regulator HT745_RS22460 ENOG4108R85 Short chain dehydrogenase HT745_RS22470 ENOG4105E39 Enoyl-CoA hydratase HT745_RS22475 ENOG4105CD5 CoA-binding domain protein HT745_RS22480 ENOG4105CC9 acyl-Coa dehydrogenase HT745_RS22490 ENOG4105CHR reductase HT745_RS22515 ENOG4105DU0 nucleoside hydrolase HT745_RS22530 ENOG4105EAD ABC transporter HT745_RS22540 ENOG4105C28 cystathionine HT745_RS22545 ENOG4105BZ1 (ABC) transporter HT745_RS22550 ENOG4107QPN acyl-Coa dehydrogenase HT745_RS22560 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HT745_RS22565 ENOG4105CYC Transferase HT745_RS22580 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HT745_RS22585 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HT745_RS22590 ENOG4108NH8 Cation transport protein HT745_RS22595 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HT745_RS22635 ENOG4105CH2 amidohydrolase HT745_RS22645 ENOG4105C26 Dehydrogenase HT745_RS22650 ENOG4105C7B Threonine dehydratase HT745_RS22655 ENOG4108SGR YheO domain-containing protein HT745_RS22660 ENOG4105C5W Aldolase HT745_RS22665 ENOG4105E9F Enoyl-CoA hydratase HT745_RS22675 ENOG4105CDA abc transporter atp-binding protein HT745_RS22730 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HT745_RS22735 ENOG4105QAX Iron-sulfur HT745_RS22740 ENOG4108MG3 formate dehydrogenase HT745_RS22745 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HT745_RS22750 ENOG4105FDP GntR family transcriptional regulator HT745_RS22755 ENOG4108UKI Enoyl-CoA hydratase HT745_RS22760 ENOG4108UKI Enoyl-CoA hydratase HT745_RS22775 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS22780 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS22785 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS22805 ENOG4105F2C Acetyl-CoA acetyltransferase HT745_RS22810 ENOG4105CDA abc transporter atp-binding protein HT745_RS22815 ENOG4105E5Q amino acid AbC transporter HT745_RS22820 ENOG4105EAB amino acid AbC transporter HT745_RS22825 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HT745_RS22830 ENOG4105CNN ABC, transporter HT745_RS22835 ENOG4105C2J ABC transporter HT745_RS22850 ENOG4105C93 Xylose Isomerase HT745_RS22855 ENOG41060NJ transcriptional regulator HT745_RS22870 ENOG4105DEF Extracellular solute-binding protein, family 5 HT745_RS22880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS22885 ENOG4105C3U ABC transporter HT745_RS22890 ENOG4108JQ6 ABC transporter HT745_RS22895 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HT745_RS22905 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HT745_RS22915 ENOG4105E9Z Nad-dependent epimerase dehydratase HT745_RS22920 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS22935 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS22940 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HT745_RS22945 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HT745_RS22950 ENOG4105BZU Histidine kinase HT745_RS22975 ENOG4105CPQ Dehydrogenase HT745_RS22985 ENOG4105C32 Amino acid ABC transporter (Permease) HT745_RS22990 ENOG4108IV0 ABC, transporter HT745_RS22995 ENOG4105C0Z ABC transporter HT745_RS23005 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HT745_RS23020 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HT745_RS23035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS23040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT745_RS23045 ENOG4105DEF Extracellular solute-binding protein, family 5 HT745_RS23055 ENOG4105EQN UPF0261 protein HT745_RS23060 ENOG4105C26 Dehydrogenase HT745_RS23085 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HT745_RS23090 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS23100 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HT745_RS23105 ENOG4105CPQ Dehydrogenase HT745_RS23110 ENOG4105C5I Dehydrogenase HT745_RS23115 ENOG4105CHR reductase HT745_RS23120 ENOG4105CXK mandelate racemase muconate lactonizing HT745_RS23125 ENOG4105FDP GntR family transcriptional regulator HT745_RS23130 ENOG4105E0K tonB-dependent siderophore receptor HT745_RS23140 ENOG4105DQ5 transport system permease protein HT745_RS23145 ENOG4108U1V ABC transporter, permease HT745_RS23150 ENOG4105E0A ABC, transporter HT745_RS23155 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS23165 ENOG4105C3S Mate efflux family protein HT745_RS23175 ENOG4105NIV Esterase HT745_RS23185 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HT745_RS23200 ENOG4107RUE extracellular solute-binding protein family 1 HT745_RS23205 ENOG4105D38 putrescine abc transporter HT745_RS23210 ENOG4105F38 ABC transporter, permease HT745_RS23215 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HT745_RS23225 ENOG4105EFZ amidohydrolase HT745_RS23245 ENOG4105CFQ glutamine synthetase HT745_RS23250 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HT745_RS23260 ENOG4105CFQ glutamine synthetase HT745_RS23265 ENOG4105CJP fad dependent oxidoreductase HT745_RS23270 ENOG4105E89 ABC transporter HT745_RS23285 ENOG4105DRR Transcriptional regulator, GntR family HT745_RS23290 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HT745_RS23305 ENOG4105E0A ABC, transporter HT745_RS23310 ENOG4105EHG Permease protein HT745_RS23325 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HT745_RS23330 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HT745_RS23335 ENOG4105CIA precorrin-4 C(11)-methyltransferase HT745_RS23350 ENOG4105QUC reductase HT745_RS23390 ENOG4105DDW LysR family Transcriptional regulator HT745_RS23410 ENOG4105DZG Dehydrogenase HT745_RS23415 ENOG4105DVH amino acid HT745_RS23420 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HT745_RS23425 ENOG4105BZ9 Cytochrome C oxidase, subunit I HT745_RS23475 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HT745_RS23490 ENOG4105CEY Amp-dependent synthetase and ligase HT745_RS23495 ENOG4105C1G acyl-Coa dehydrogenase HT745_RS23505 ENOG4105FA0 parb-like partition protein HT745_RS23555 ENOG4108BI7 Toxic component of a toxin-antitoxin (TA) module. A HT745_RS23675 ENOG4105CMA conjugation trbi family protein HT745_RS23695 ENOG4105E4C Lytic transglycosylase catalytic HT745_RS23715 ENOG4105E4C Lytic transglycosylase catalytic HT745_RS23760 ENOG4107ZYJ bioY protein HT745_RS23765 ENOG4108JJB ABC transporter HT745_RS23800 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HT745_RS23830 ENOG4105C3J Cysteine desulfurase HT745_RS23840 ENOG4108HWW ABC transporter HT745_RS23850 ENOG4105DFW ABC transporter HT745_RS23865 ENOG4108KPJ rna polymerase sigma factor HT745_RS23895 ENOG4107RKG DJ-1/PfpI family HT745_RS23910 ENOG4105JJR Histidine kinase HT745_RS23915 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT745_RS23920 ENOG4105C0H protease HT745_RS23960 ENOG4107HP6 Transcriptional regulator HT745_RS23965 ENOG4107QP7 CoA-transferase subunit A HT745_RS23970 ENOG4107QNJ CoA-transferase subunit B HT745_RS23980 ENOG4105C26 Dehydrogenase HT745_RS23985 ENOG4107RR1 TRANSCRIPTIONal HT745_RS23990 ENOG4105CYM Glutathione S-transferase HT745_RS23995 ENOG4105CQB FAD linked oxidase domain protein HT745_RS24000 ENOG4105C7K acetolactate synthase HT745_RS24015 ENOG4105JXH GntR family transcriptional regulator HT745_RS24025 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase HT745_RS24040 ENOG4108JQ5 ABC transporter HT745_RS24045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT745_RS24050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT745_RS24055 ENOG4105DEF Extracellular solute-binding protein, family 5 HT745_RS24065 ENOG4105CKI cobalamin synthesis protein HT745_RS24075 ENOG4105WAB arsR family transcriptional regulator HT745_RS24080 ENOG4105EBM Alpha Beta Hydrolase Fold protein HT745_RS24090 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HT745_RS24095 ENOG4105C2C drug resistance transporter, Bcr CflA HT745_RS24100 ENOG4108JQ1 Dehydrogenase HT745_RS24115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HT745_RS24130 ENOG4105DRR Transcriptional regulator, GntR family HT745_RS24135 ENOG4105CTX dehydratase HT745_RS24145 ENOG4105C8M UPF0272 protein HT745_RS24160 ENOG4105C1B dTDP-glucose 4-6-dehydratase