locus-tag	class	description
IT972_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IT972_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IT972_RS00030	COG1309	transcriptional regulator
IT972_RS00035	COG4221	oxidoreductase activity
IT972_RS00085	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IT972_RS00090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IT972_RS00105	COG0284	orotidine-5'-phosphate decarboxylase activity
IT972_RS00110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IT972_RS00125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IT972_RS00130	COG0625	glutathione transferase activity
IT972_RS00135	COG1840	ABC-type Fe3 transport system, periplasmic component
IT972_RS00140	COG1178	ABC-type Fe3 transport system permease component
IT972_RS00145	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IT972_RS00165	COG0559	Belongs to the binding-protein-dependent transport system permease family
IT972_RS00205	COG3383	formate dehydrogenase (NAD+) activity
IT972_RS00215	COG0625	glutathione transferase activity
IT972_RS00255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IT972_RS00270	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IT972_RS00275	COG3257	ureidoglycine aminohydrolase activity
IT972_RS00285	COG2351	hydroxyisourate hydrolase activity
IT972_RS00295	COG1012	belongs to the aldehyde dehydrogenase family
IT972_RS00300	COG0612	Peptidase, M16
IT972_RS00305	COG0612	Peptidase, M16
IT972_RS00320	COG0138	bifunctional purine biosynthesis protein purh
IT972_RS00330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IT972_RS00330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IT972_RS00345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IT972_RS00350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IT972_RS00355	COG3698	Phosphodiester glycosidase
IT972_RS00360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IT972_RS00375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IT972_RS00385	COG1185	polyribonucleotide nucleotidyltransferase activity
IT972_RS00415	COG0489	protein tyrosine kinase activity
IT972_RS00450	COG0243	molybdopterin cofactor binding
IT972_RS00450	COG3383	formate dehydrogenase (NAD+) activity
IT972_RS00455	COG0437	4 iron, 4 sulfur cluster binding
IT972_RS00470	COG3842	ATPase activity
IT972_RS00485	COG0450	alkyl hydroperoxide reductase
IT972_RS00495	COG0564	pseudouridine synthase activity
IT972_RS00520	COG0183	Belongs to the thiolase family
IT972_RS00525	COG1366	Belongs to the anti-sigma-factor antagonist family
IT972_RS00535	COG0405	Gamma-glutamyltransferase
IT972_RS00560	COG1674	ftsk spoiiie
IT972_RS00565	COG0436	Aminotransferase
IT972_RS00570	COG0154	amidase activity
IT972_RS00575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT972_RS00580	COG2835	tetraacyldisaccharide 4'-kinase activity
IT972_RS00595	COG0708	Exodeoxyribonuclease III
IT972_RS00600	COG0745	RESPONSE REGULATOR receiver
IT972_RS00615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IT972_RS00630	COG0495	leucyl-tRNA aminoacylation
IT972_RS00670	COG0312	modulator of DNA gyrase
IT972_RS00685	COG1519	Transferase
IT972_RS00690	COG1663	tetraacyldisaccharide 4'-kinase activity
IT972_RS00710	COG1194	a g-specific adenine glycosylase
IT972_RS00725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IT972_RS00745	COG1609	Transcriptional regulator
IT972_RS00750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT972_RS00765	COG0129	dihydroxy-acid dehydratase activity
IT972_RS00785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IT972_RS00795	COG0288	reversible hydration of carbon dioxide
IT972_RS00805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT972_RS00810	COG0791	NLP P60 protein
IT972_RS00820	COG2050	protein possibly involved in aromatic compounds catabolism
IT972_RS00835	COG0679	Auxin Efflux Carrier
IT972_RS00840	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IT972_RS00845	COG1671	Belongs to the UPF0178 family
IT972_RS00855	COG2423	ornithine cyclodeaminase activity
IT972_RS00860	COG0596	Alpha beta hydrolase
IT972_RS00870	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IT972_RS00880	COG0285	dihydrofolate synthase activity
IT972_RS00885	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IT972_RS00895	COG2274	protein secretion by the type I secretion system
IT972_RS00900	COG0129	dihydroxy-acid dehydratase activity
IT972_RS00920	COG0569	domain protein
IT972_RS00925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IT972_RS00930	COG0793	Belongs to the peptidase S41A family
IT972_RS00940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IT972_RS00955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT972_RS00955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IT972_RS00960	COG3622	Belongs to the hyi family
IT972_RS00970	COG0714	Associated with various cellular activities
IT972_RS00990	COG0784	Response regulator, receiver
IT972_RS00990	COG5002	protein histidine kinase activity
IT972_RS00990	COG2205	protein histidine kinase activity
IT972_RS00995	COG3022	response to hydroperoxide
IT972_RS01000	COG0514	ATP-dependent DNA helicase (RecQ)
IT972_RS01020	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IT972_RS01030	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IT972_RS01045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IT972_RS01050	COG2095	MarC family integral membrane protein
IT972_RS01055	COG1335	isochorismatase
IT972_RS01060	COG1054	Belongs to the UPF0176 family
IT972_RS01065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IT972_RS01070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT972_RS01075	COG1177	transmembrane transport
IT972_RS01080	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT972_RS01085	COG3842	ATPase activity
IT972_RS01095	COG1802	Transcriptional regulator
IT972_RS01105	COG3842	ATPase activity
IT972_RS01125	COG2951	lytic endotransglycosylase activity
IT972_RS01130	COG0557	exoribonuclease II activity
IT972_RS01145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT972_RS01160	COG2171	N-acyltransferase activity
IT972_RS01175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IT972_RS01190	COG0560	Phosphoserine phosphatase
IT972_RS01195	COG0183	Belongs to the thiolase family
IT972_RS01200	COG3396	Phenylacetate-CoA oxygenase
IT972_RS01205	COG3460	Phenylacetate-CoA oxygenase
IT972_RS01210	COG3396	Phenylacetate-CoA oxygenase
IT972_RS01215	COG2151	metal-sulfur cluster biosynthetic enzyme
IT972_RS01220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IT972_RS01225	COG2030	dehydratase
IT972_RS01225	COG1012	belongs to the aldehyde dehydrogenase family
IT972_RS01240	COG0517	IMP dehydrogenase activity
IT972_RS01240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IT972_RS01255	COG1137	ATPase activity
IT972_RS01260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IT972_RS01265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT972_RS01290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IT972_RS01300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IT972_RS01320	COG0443	Heat shock 70 kDa protein
IT972_RS01325	COG0484	heat shock protein binding
IT972_RS01330	COG2003	Belongs to the UPF0758 family
IT972_RS01350	COG0489	protein tyrosine kinase activity
IT972_RS01350	COG3206	protein involved in exopolysaccharide biosynthesis
IT972_RS01360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IT972_RS01360	COG3008	intermembrane lipid transfer
IT972_RS01365	COG2995	paraquat-inducible protein a
IT972_RS01375	COG0693	protein deglycase activity
IT972_RS01410	COG0069	glutamate synthase activity
IT972_RS01415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IT972_RS01420	COG1396	sequence-specific DNA binding
IT972_RS01445	COG0784	Response regulator, receiver
IT972_RS01470	COG1295	ribonuclease BN
IT972_RS01475	COG2116	formate transmembrane transporter activity
IT972_RS01485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT972_RS01490	COG0443	Heat shock 70 kDa protein
IT972_RS01495	COG0747	negative chemotaxis
IT972_RS01530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT972_RS01550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT972_RS01560	COG3191	aminopeptidase activity
IT972_RS01565	COG3474	cytochrome
IT972_RS01595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IT972_RS01600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IT972_RS01605	COG2350	Protein conserved in bacteria
IT972_RS01620	COG1858	cytochrome C peroxidase
IT972_RS01630	COG1940	carbohydrate kinase activity
IT972_RS01635	COG4213	ABC transporter substrate-binding protein
IT972_RS01640	COG4214	carbohydrate transport
IT972_RS01645	COG1129	ABC transporter
IT972_RS01650	COG1070	Carbohydrate kinase
IT972_RS01655	COG2115	Belongs to the xylose isomerase family
IT972_RS01665	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IT972_RS01675	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IT972_RS01685	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IT972_RS01690	COG1999	signal sequence binding
IT972_RS01700	COG2205	protein histidine kinase activity
IT972_RS01705	COG0802	atpase or kinase
IT972_RS01710	COG3178	'Phosphotransferase
IT972_RS01715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IT972_RS01740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IT972_RS01745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IT972_RS01775	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IT972_RS01780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IT972_RS01785	COG0237	dephospho-CoA kinase activity
IT972_RS01795	COG0424	maF-like protein
IT972_RS01800	COG1981	membrane
IT972_RS01805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IT972_RS01810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IT972_RS01815	COG0445	tRNA wobble uridine modification
IT972_RS01820	COG0357	Ribosomal RNA small subunit methyltransferase G
IT972_RS01835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IT972_RS01840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IT972_RS01845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IT972_RS01855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IT972_RS01860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IT972_RS01865	COG0280	phosphate acetyltransferase
IT972_RS01865	COG0281	malic enzyme
IT972_RS01875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT972_RS01895	COG0137	argininosuccinate synthase activity
IT972_RS01900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IT972_RS01925	COG0494	nUDIX hydrolase
IT972_RS01930	COG0617	tRNA 3'-terminal CCA addition
IT972_RS01935	COG1132	(ABC) transporter
IT972_RS01940	COG1132	(ABC) transporter
IT972_RS01955	COG3034	peptidoglycan biosynthetic process
IT972_RS01985	COG1040	competence protein
IT972_RS01995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT972_RS02005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IT972_RS02020	COG0779	Required for maturation of 30S ribosomal subunits
IT972_RS02035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IT972_RS02045	COG1803	Methylglyoxal synthase
IT972_RS02045	COG1597	lipid kinase activity
IT972_RS02050	COG0494	nUDIX hydrolase
IT972_RS02055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IT972_RS02060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT972_RS02065	COG0653	protein targeting
IT972_RS02080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IT972_RS02085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT972_RS02100	COG0463	Glycosyl transferase, family 2
IT972_RS02125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IT972_RS02185	COG0110	maltose O-acetyltransferase activity
IT972_RS02195	COG0709	Synthesizes selenophosphate from selenide and ATP
IT972_RS02205	COG4717	serine-type aminopeptidase activity
IT972_RS02255	COG1968	undecaprenyl-diphosphatase activity
IT972_RS02275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IT972_RS02285	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IT972_RS02295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT972_RS02305	COG0697	spore germination
IT972_RS02315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IT972_RS02320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IT972_RS02325	COG0438	transferase activity, transferring glycosyl groups
IT972_RS02340	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IT972_RS02345	COG1178	ABC-type Fe3 transport system permease component
IT972_RS02350	COG4143	(ABC) transporter
IT972_RS02355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IT972_RS02370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IT972_RS02375	COG1846	Transcriptional regulator
IT972_RS02380	COG0745	RESPONSE REGULATOR receiver
IT972_RS02385	COG1722	exodeoxyribonuclease VII activity
IT972_RS02390	COG0142	geranyltranstransferase activity
IT972_RS02395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IT972_RS02405	COG2808	Putative FMN-binding domain
IT972_RS02410	COG0625	glutathione transferase activity
IT972_RS02435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IT972_RS02440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IT972_RS02450	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IT972_RS02460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IT972_RS02475	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT972_RS02480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT972_RS02485	COG3214	Protein conserved in bacteria
IT972_RS02490	COG1609	Transcriptional regulator
IT972_RS02510	COG3707	response regulator
IT972_RS02515	COG1116	anion transmembrane transporter activity
IT972_RS02515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT972_RS02520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT972_RS02525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT972_RS02530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT972_RS02530	COG1116	anion transmembrane transporter activity
IT972_RS02535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT972_RS02540	COG2146	nitrite reductase [NAD(P)H] activity
IT972_RS02545	COG0243	molybdopterin cofactor binding
IT972_RS02555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IT972_RS02555	COG1648	precorrin-2 dehydrogenase activity
IT972_RS02565	COG4774	siderophore transport
IT972_RS02570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IT972_RS02575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT972_RS02580	COG1120	ATPase activity
IT972_RS02585	COG1132	(ABC) transporter
IT972_RS02590	COG0642	Histidine kinase
IT972_RS02595	COG0745	RESPONSE REGULATOR receiver
IT972_RS02605	COG2194	sulfuric ester hydrolase activity
IT972_RS02615	COG0473	3-isopropylmalate dehydrogenase activity
IT972_RS02630	COG0066	3-isopropylmalate dehydratase activity
IT972_RS02635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IT972_RS02640	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IT972_RS02640	COG3264	Mechanosensitive ion channel
IT972_RS02645	COG0799	negative regulation of ribosome biogenesis
IT972_RS02650	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IT972_RS02665	COG0277	FAD linked oxidase domain protein
IT972_RS02670	COG0277	FAD linked oxidase domain protein
IT972_RS02680	COG0247	lactate metabolic process
IT972_RS02695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT972_RS02700	COG1012	belongs to the aldehyde dehydrogenase family
IT972_RS02745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IT972_RS02750	COG2897	thiosulfate sulfurtransferase activity
IT972_RS02760	COG0004	ammonium transporteR
IT972_RS02765	COG0347	Belongs to the P(II) protein family
IT972_RS02780	COG0583	DNA-binding transcription factor activity
IT972_RS02785	COG2853	Lipoprotein
IT972_RS02805	COG2154	pterin-4-alpha-carbinolamine dehydratase
IT972_RS02810	COG0678	peroxiredoxin activity
IT972_RS02820	COG0742	ribosomal rna small subunit methyltransferase
IT972_RS02830	COG1183	phosphatidylcholine synthase activity
IT972_RS02835	COG0024	Methionine aminopeptidase
IT972_RS02840	COG1489	DNA binding
IT972_RS02845	COG1546	Belongs to the CinA family
IT972_RS02845	COG1058	Belongs to the CinA family
IT972_RS02865	COG0583	DNA-binding transcription factor activity
IT972_RS02875	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT972_RS02875	COG1902	pentaerythritol trinitrate reductase activity
IT972_RS02880	COG1051	belongs to the nudix hydrolase family
IT972_RS02895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IT972_RS02900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IT972_RS02905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IT972_RS02920	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IT972_RS02920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT972_RS02925	COG0697	spore germination
IT972_RS02930	COG0741	lytic transglycosylase activity
IT972_RS02935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IT972_RS02945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT972_RS02965	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IT972_RS02970	COG0830	nickel cation binding
IT972_RS02975	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IT972_RS02980	COG0804	urea catabolic process
IT972_RS02985	COG0832	Belongs to the urease beta subunit family
IT972_RS02995	COG0831	urea catabolic process
IT972_RS03000	COG0829	nickel cation binding
IT972_RS03020	COG1917	Cupin 2, conserved barrel domain protein
IT972_RS03020	COG2207	Transcriptional regulator
IT972_RS03035	COG1309	transcriptional regulator
IT972_RS03060	COG0825	malonyl-CoA metabolic process
IT972_RS03070	COG2301	Belongs to the HpcH HpaI aldolase family
IT972_RS03080	COG4948	Mandelate Racemase Muconate Lactonizing
IT972_RS03095	COG0469	pyruvate kinase activity
IT972_RS03105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IT972_RS03110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IT972_RS03120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IT972_RS03130	COG0072	phenylalanine-tRNA ligase activity
IT972_RS03130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT972_RS03140	COG1970	mechanosensitive ion channel activity
IT972_RS03145	COG0686	Belongs to the AlaDH PNT family
IT972_RS03150	COG1522	sequence-specific DNA binding
IT972_RS03160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IT972_RS03170	COG1122	ATPase activity
IT972_RS03175	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IT972_RS03195	COG2197	response regulator
IT972_RS03215	COG0019	diaminopimelate decarboxylase activity
IT972_RS03220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IT972_RS03235	COG0745	RESPONSE REGULATOR receiver
IT972_RS03240	COG0346	lactoylglutathione lyase activity
IT972_RS03255	COG0778	Nitroreductase
IT972_RS03265	COG0180	Tryptophanyl-tRNA synthetase
IT972_RS03275	COG0728	peptidoglycan biosynthetic process
IT972_RS03280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IT972_RS03290	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IT972_RS03300	COG0189	ligase activity
IT972_RS03310	COG0606	chelatase, subunit chli
IT972_RS03325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IT972_RS03335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IT972_RS03340	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IT972_RS03345	COG3639	organic phosphonate transmembrane transporter activity
IT972_RS03350	COG3639	organic phosphonate transmembrane transporter activity
IT972_RS03360	COG2188	Transcriptional regulator
IT972_RS03365	COG3624	Phosphonate C-P lyase system protein PhnG
IT972_RS03370	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IT972_RS03375	COG3626	phosphonate metabolism
IT972_RS03380	COG3627	carbon phosphorus lyase activity
IT972_RS03385	COG4107	phosphonate C-P lyase system protein PhnK
IT972_RS03390	COG4778	phosphonate C-P lyase system protein PhnL
IT972_RS03400	COG3454	Phosphonate metabolism
IT972_RS03405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IT972_RS03410	COG0339	signal peptide processing
IT972_RS03415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT972_RS03420	COG0772	Belongs to the SEDS family
IT972_RS03425	COG0768	penicillin binding
IT972_RS03455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT972_RS03465	COG3046	protein related to deoxyribodipyrimidine photolyase
IT972_RS03480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT972_RS03495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT972_RS03500	COG0509	glycine decarboxylation via glycine cleavage system
IT972_RS03505	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IT972_RS03505	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IT972_RS03515	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IT972_RS03520	COG4181	ATPase activity
IT972_RS03530	COG1278	Cold shock
IT972_RS03535	COG0493	'glutamate synthase
IT972_RS03545	COG1309	transcriptional regulator
IT972_RS03565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT972_RS03570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT972_RS03575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT972_RS03580	COG1376	ErfK ybiS ycfS ynhG family protein
IT972_RS03585	COG1278	Cold shock
IT972_RS03595	COG0488	(ABC) transporter
IT972_RS03605	COG1115	amino acid carrier protein
IT972_RS03610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IT972_RS03620	COG2027	D-alanyl-D-alanine carboxypeptidase
IT972_RS03630	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IT972_RS03670	COG0556	nucleotide-excision repair
IT972_RS03690	COG1921	L-seryl-tRNASec selenium transferase activity
IT972_RS03720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IT972_RS03725	COG2971	BadF BadG BcrA BcrD
IT972_RS03730	COG0129	dihydroxy-acid dehydratase activity
IT972_RS03735	COG0800	Aldolase
IT972_RS03755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT972_RS03760	COG0165	Argininosuccinate lyase
IT972_RS03775	COG0019	diaminopimelate decarboxylase activity
IT972_RS03790	COG2884	Cell division ATP-binding protein ftsE
IT972_RS03820	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT972_RS03845	COG0045	succinate-CoA ligase (ADP-forming) activity
IT972_RS03850	COG2030	dehydratase
IT972_RS03880	COG0039	L-malate dehydrogenase activity
IT972_RS03925	COG0813	purine-nucleoside phosphorylase activity
IT972_RS03935	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT972_RS03935	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT972_RS03940	COG2937	Belongs to the GPAT DAPAT family
IT972_RS03945	COG0604	alcohol dehydrogenase
IT972_RS03950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IT972_RS03960	COG0730	response to heat
IT972_RS03965	COG1079	Belongs to the binding-protein-dependent transport system permease family
IT972_RS03970	COG4603	Belongs to the binding-protein-dependent transport system permease family
IT972_RS03975	COG3845	ABC transporter
IT972_RS03980	COG1744	ABC transporter substrate-binding protein PnrA-like
IT972_RS03985	COG0456	acetyltransferase
IT972_RS03990	COG1214	PFAM Peptidase M22, glycoprotease
IT972_RS03995	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IT972_RS04025	COG1272	protein, Hemolysin III
IT972_RS04035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IT972_RS04045	COG0133	tryptophan synthase activity
IT972_RS04070	COG0193	aminoacyl-tRNA hydrolase activity
IT972_RS04075	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IT972_RS04085	COG0159	tryptophan synthase activity
IT972_RS04095	COG0012	GTP binding
IT972_RS04105	COG4221	oxidoreductase activity
IT972_RS04110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT972_RS04130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IT972_RS04140	COG1643	Atp-dependent helicase
IT972_RS04145	COG1703	isobutyryl-CoA mutase activity
IT972_RS04160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IT972_RS04195	COG0632	four-way junction helicase activity
IT972_RS04200	COG2255	four-way junction helicase activity
IT972_RS04210	COG0824	Thioesterase
IT972_RS04230	COG0823	Involved in the tonB-independent uptake of proteins
IT972_RS04235	COG2885	chlorophyll binding
IT972_RS04245	COG0037	tRNA processing
IT972_RS04250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IT972_RS04260	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IT972_RS04265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IT972_RS04280	COG1201	RNA secondary structure unwinding
IT972_RS04330	COG4964	Belongs to the GSP D family
IT972_RS04345	COG0741	lytic transglycosylase activity
IT972_RS04350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IT972_RS04365	COG1754	DNA topoisomerase type I activity
IT972_RS04365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IT972_RS04370	COG0758	DNA mediated transformation
IT972_RS04375	COG0312	modulator of DNA gyrase
IT972_RS04385	COG0109	protoheme IX farnesyltransferase activity
IT972_RS04395	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IT972_RS04405	COG3346	SURF1 family
IT972_RS04415	COG0612	Peptidase, M16
IT972_RS04435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IT972_RS04440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IT972_RS04450	COG0306	phosphate transporter
IT972_RS04460	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IT972_RS04465	COG0101	tRNA pseudouridine synthase activity
IT972_RS04470	COG3106	COG3106 Predicted ATPase
IT972_RS04480	COG3768	UPF0283 membrane protein
IT972_RS04485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IT972_RS04495	COG1183	phosphatidylcholine synthase activity
IT972_RS04500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IT972_RS04515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IT972_RS04520	COG0583	DNA-binding transcription factor activity
IT972_RS04525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IT972_RS04530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IT972_RS04535	COG0424	maF-like protein
IT972_RS04545	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IT972_RS04580	COG1309	transcriptional regulator
IT972_RS04605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IT972_RS04610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT972_RS04635	COG0702	epimerase
IT972_RS04660	COG0583	DNA-binding transcription factor activity
IT972_RS04665	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IT972_RS04675	COG1053	succinate dehydrogenase
IT972_RS04675	COG3976	FMN-binding domain protein
IT972_RS04680	COG1802	Transcriptional regulator
IT972_RS04690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT972_RS04705	COG2828	Protein conserved in bacteria
IT972_RS04725	COG2205	protein histidine kinase activity
IT972_RS04730	COG3328	transposase activity
IT972_RS04740	COG0583	DNA-binding transcription factor activity
IT972_RS04745	COG2388	GCN5-related N-acetyl-transferase
IT972_RS04760	COG0604	alcohol dehydrogenase
IT972_RS04760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IT972_RS04760	COG3321	synthase
IT972_RS04760	COG4221	oxidoreductase activity
IT972_RS04765	COG1024	Enoyl-CoA hydratase
IT972_RS04770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IT972_RS04775	COG0022	dehydrogenase e1 component
IT972_RS04790	COG0095	Lipoate-protein ligase
IT972_RS04800	COG2204	response regulator
IT972_RS04825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IT972_RS04850	COG1172	Belongs to the binding-protein-dependent transport system permease family
IT972_RS04875	COG2323	membrane
IT972_RS04890	COG0848	biopolymer transport protein
IT972_RS04900	COG3128	pkhd-type hydroxylase
IT972_RS04905	COG4774	siderophore transport
IT972_RS04930	COG0778	Nitroreductase
IT972_RS04950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IT972_RS04960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IT972_RS04965	COG5328	Belongs to the UPF0262 family
IT972_RS04985	COG0481	GTPase activity
IT972_RS05000	COG0588	phosphoglycerate mutase activity
IT972_RS05005	COG0438	transferase activity, transferring glycosyl groups
IT972_RS05020	COG0668	transmembrane transport
IT972_RS05025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IT972_RS05030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT972_RS05040	COG0747	negative chemotaxis
IT972_RS05045	COG4172	Belongs to the ABC transporter superfamily
IT972_RS05075	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT972_RS05075	COG1024	Enoyl-CoA hydratase
IT972_RS05080	COG1960	acyl-CoA dehydrogenase activity
IT972_RS05085	COG1960	acyl-CoA dehydrogenase activity
IT972_RS05095	COG1024	Enoyl-CoA hydratase
IT972_RS05100	COG0318	PFAM AMP-dependent synthetase and ligase
IT972_RS05120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT972_RS05145	COG0785	Cytochrome C biogenesis protein
IT972_RS05170	COG3258	Cytochrome c
IT972_RS05175	COG0737	Belongs to the 5'-nucleotidase family
IT972_RS05205	COG0318	PFAM AMP-dependent synthetase and ligase
IT972_RS05210	COG0028	Belongs to the TPP enzyme family
IT972_RS05215	COG0668	transmembrane transport
IT972_RS05225	COG2943	transferase activity, transferring hexosyl groups
IT972_RS05235	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IT972_RS05240	COG1757	Na H antiporter
IT972_RS05245	COG0318	PFAM AMP-dependent synthetase and ligase
IT972_RS05250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT972_RS05255	COG3608	succinylglutamate desuccinylase aspartoacylase
IT972_RS05260	COG0006	proline dipeptidase activity
IT972_RS05265	COG1522	sequence-specific DNA binding
IT972_RS05275	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IT972_RS05280	COG2202	Pas domain
IT972_RS05280	COG3920	Histidine kinase
IT972_RS05285	COG4191	Histidine kinase
IT972_RS05285	COG0784	Response regulator, receiver
IT972_RS05315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IT972_RS05320	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IT972_RS05325	COG2080	2 iron, 2 sulfur cluster binding
IT972_RS05330	COG0583	DNA-binding transcription factor activity
IT972_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
IT972_RS05350	COG0604	alcohol dehydrogenase
IT972_RS05370	COG0277	FAD linked oxidase domain protein
IT972_RS05385	COG3757	hydrolase, family 25
IT972_RS05400	COG0625	glutathione transferase activity
IT972_RS05420	COG1079	Belongs to the binding-protein-dependent transport system permease family
IT972_RS05425	COG4603	Belongs to the binding-protein-dependent transport system permease family
IT972_RS05430	COG3845	ABC transporter
IT972_RS05440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IT972_RS05455	COG2900	Belongs to the SlyX family
IT972_RS05460	COG0124	histidyl-tRNA synthetase
IT972_RS05490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IT972_RS05515	COG0798	PFAM Bile acid sodium symporter
IT972_RS05525	COG0431	NADPH-dependent FMN reductase
IT972_RS05535	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IT972_RS05565	COG1175	transmembrane transport
IT972_RS05570	COG0395	ABC-type sugar transport system, permease component
IT972_RS05580	COG0129	dihydroxy-acid dehydratase activity
IT972_RS05585	COG1028	Short-chain dehydrogenase reductase Sdr
IT972_RS05590	COG3734	2-keto-3-deoxy-galactonokinase
IT972_RS05595	COG0800	Aldolase
IT972_RS05600	COG3386	PFAM SMP-30 Gluconolaconase
IT972_RS05610	COG1464	Belongs to the NlpA lipoprotein family
IT972_RS05615	COG2011	ABC-type metal ion transport system permease component
IT972_RS05620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IT972_RS05635	COG1522	sequence-specific DNA binding
IT972_RS05645	COG1448	Aminotransferase
IT972_RS05655	COG3268	Saccharopine dehydrogenase
IT972_RS05660	COG1115	amino acid carrier protein
IT972_RS05665	COG0252	asparaginase activity
IT972_RS05690	COG3443	Belongs to the bacterial solute-binding protein 9 family
IT972_RS05695	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT972_RS05710	COG0154	amidase activity
IT972_RS05730	COG3483	tryptophan 2,3-dioxygenase activity
IT972_RS05740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IT972_RS05745	COG0589	response to stress
IT972_RS05750	COG0583	DNA-binding transcription factor activity
IT972_RS05780	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IT972_RS05805	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IT972_RS05810	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IT972_RS05825	COG2951	lytic endotransglycosylase activity
IT972_RS05835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IT972_RS05870	COG3246	L-lysine catabolic process to acetate
IT972_RS05875	COG3485	protocatechuate 3,4-dioxygenase
IT972_RS05880	COG3485	protocatechuate 3,4-dioxygenase
IT972_RS05885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IT972_RS05890	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IT972_RS05895	COG2080	2 iron, 2 sulfur cluster binding
IT972_RS05900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IT972_RS05900	COG2010	Cytochrome c
IT972_RS05910	COG0318	PFAM AMP-dependent synthetase and ligase
IT972_RS05920	COG1132	(ABC) transporter
IT972_RS05925	COG1652	LysM domain
IT972_RS05930	COG0318	PFAM AMP-dependent synthetase and ligase
IT972_RS05935	COG0657	acetylesterase activity
IT972_RS05945	COG4172	Belongs to the ABC transporter superfamily
IT972_RS05950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT972_RS05990	COG1490	D-aminoacyl-tRNA deacylase activity
IT972_RS06035	COG1187	pseudouridine synthase activity
IT972_RS06040	COG0590	tRNA wobble adenosine to inosine editing
IT972_RS06055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IT972_RS06060	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IT972_RS06065	COG0154	amidase activity
IT972_RS06075	COG3023	N-Acetylmuramoyl-L-alanine amidase
IT972_RS06085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IT972_RS06095	COG0670	Belongs to the BI1 family
IT972_RS06100	COG1396	sequence-specific DNA binding
IT972_RS06105	COG0483	inositol monophosphate 1-phosphatase activity
IT972_RS06120	COG0402	S-adenosylhomocysteine deaminase activity
IT972_RS06125	COG2239	Acts as a magnesium transporter
IT972_RS06130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IT972_RS06135	COG1692	metallophosphoesterase
IT972_RS06140	COG3273	potassium ion transport
IT972_RS06140	COG0471	metal ion transport
IT972_RS06145	COG3273	potassium ion transport
IT972_RS06145	COG0471	metal ion transport
IT972_RS06150	COG0217	transcriptional regulatory protein
IT972_RS06170	COG1309	transcriptional regulator
IT972_RS06175	COG3119	arylsulfatase activity
IT972_RS06200	COG3800	Transcriptional regulator
IT972_RS06200	COG1396	sequence-specific DNA binding
IT972_RS06205	COG2814	Major facilitator Superfamily
IT972_RS06210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT972_RS06235	COG4770	biotin carboxylase activity
IT972_RS06250	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT972_RS06250	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IT972_RS06265	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IT972_RS06280	COG0248	Ppx GppA phosphatase
IT972_RS06285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IT972_RS06290	COG2255	four-way junction helicase activity
IT972_RS06295	COG0628	permease
IT972_RS06305	COG0442	prolyl-tRNA aminoacylation
IT972_RS06320	COG1136	(ABC) transporter
IT972_RS06350	COG0187	DNA topoisomerase II activity
IT972_RS06355	COG0662	Cupin 2, conserved barrel domain protein
IT972_RS06360	COG0596	Alpha beta hydrolase
IT972_RS06370	COG0534	Mate efflux family protein
IT972_RS06425	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IT972_RS06440	COG1278	Cold shock
IT972_RS06445	COG1393	Belongs to the ArsC family
IT972_RS06460	COG3220	belongs to the UPF0276 family
IT972_RS06470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IT972_RS06510	COG3243	poly(R)-hydroxyalkanoic acid synthase
IT972_RS06525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IT972_RS06530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT972_RS06535	COG0174	glutamine synthetase
IT972_RS06540	COG0519	Catalyzes the synthesis of GMP from XMP
IT972_RS06545	COG0174	glutamine synthetase
IT972_RS06550	COG0765	amino acid transport
IT972_RS06555	COG4215	(ABC) transporter
IT972_RS06585	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IT972_RS06590	COG0504	CTP synthase activity
IT972_RS06605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IT972_RS06640	COG0546	phosphoglycolate phosphatase activity
IT972_RS06650	COG3706	GGDEF domain
IT972_RS06660	COG1215	transferase activity, transferring glycosyl groups
IT972_RS06670	COG3620	sequence-specific DNA binding
IT972_RS06675	COG0747	negative chemotaxis
IT972_RS06685	COG0601	transmembrane transport
IT972_RS06690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT972_RS06695	COG4172	Belongs to the ABC transporter superfamily
IT972_RS06715	COG4175	Glycine betaine
IT972_RS06715	COG3448	diguanylate cyclase activity
IT972_RS06720	COG0697	spore germination
IT972_RS06725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IT972_RS06730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IT972_RS06745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT972_RS06765	COG2207	Transcriptional regulator
IT972_RS06765	COG3708	Transcriptional regulator
IT972_RS06780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IT972_RS06805	COG1760	l-serine dehydratase
IT972_RS06810	COG0625	glutathione transferase activity
IT972_RS06815	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IT972_RS06825	COG0330	HflC and HflK could
IT972_RS06830	COG0330	HflC and HflK could
IT972_RS06835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT972_RS06855	COG1121	(ABC) transporter
IT972_RS06860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT972_RS06865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT972_RS06875	COG1175	transmembrane transport
IT972_RS06880	COG1349	DNA-binding transcription factor activity
IT972_RS06890	COG3842	ATPase activity
IT972_RS06895	COG3842	ATPase activity
IT972_RS06905	COG0395	ABC-type sugar transport system, permease component
IT972_RS06920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IT972_RS06930	COG1454	alcohol dehydrogenase
IT972_RS06935	COG0730	response to heat
IT972_RS06940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IT972_RS06950	COG3328	transposase activity
IT972_RS06985	COG3429	Glucose-6-phosphate dehydrogenase subunit
IT972_RS06985	COG3409	Peptidoglycan-binding domain 1 protein
IT972_RS07050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IT972_RS07055	COG4235	cytochrome complex assembly
IT972_RS07060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT972_RS07075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT972_RS07075	COG0446	pyridine nucleotide-disulphide oxidoreductase
IT972_RS07110	COG5265	(ABC) transporter
IT972_RS07120	COG2814	Major facilitator Superfamily
IT972_RS07125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT972_RS07145	COG1160	GTP binding
IT972_RS07155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IT972_RS07160	COG1862	Preprotein translocase
IT972_RS07165	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT972_RS07170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IT972_RS07175	COG3737	Protein of unknown function (DUF498/DUF598)
IT972_RS07180	COG4133	protoheme IX ABC transporter activity
IT972_RS07185	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT972_RS07190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IT972_RS07200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IT972_RS07230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IT972_RS07230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IT972_RS07235	COG0544	peptidyl-prolyl cis-trans isomerase activity
IT972_RS07265	COG1234	tRNA 3'-trailer cleavage
IT972_RS07270	COG0084	hydrolase, TatD family'
IT972_RS07280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IT972_RS07285	COG1686	Belongs to the peptidase S11 family
IT972_RS07305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IT972_RS07325	COG2205	protein histidine kinase activity
IT972_RS07325	COG2202	Pas domain
IT972_RS07330	COG1349	DNA-binding transcription factor activity
IT972_RS07345	COG3639	organic phosphonate transmembrane transporter activity
IT972_RS07355	COG1011	Hydrolase
IT972_RS07370	COG0811	peptide transport
IT972_RS07400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IT972_RS07405	COG1121	(ABC) transporter
IT972_RS07435	COG0740	serine-type endopeptidase activity
IT972_RS07440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IT972_RS07460	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IT972_RS07465	COG0439	Biotin carboxylase
IT972_RS07470	COG0511	ligase activity, forming carbon-carbon bonds
IT972_RS07475	COG0410	ABC transporter
IT972_RS07500	COG1396	sequence-specific DNA binding
IT972_RS07500	COG3800	Transcriptional regulator
IT972_RS07540	COG3750	Belongs to the UPF0335 family
IT972_RS07545	COG0544	peptidyl-prolyl cis-trans isomerase activity
IT972_RS07560	COG0359	binds to the 23S rRNA
IT972_RS07565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IT972_RS07570	COG0360	Binds together with S18 to 16S ribosomal RNA
IT972_RS07580	COG2353	YceI-like domain
IT972_RS07585	COG3038	cytochrome b561
IT972_RS07590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IT972_RS07600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IT972_RS07610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT972_RS07615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IT972_RS07625	COG4695	Portal protein
IT972_RS07705	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT972_RS07710	COG0022	dehydrogenase e1 component
IT972_RS07710	COG0508	dehydrogenase complex catalyzes the overall conversion of
IT972_RS07715	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IT972_RS07725	COG0126	phosphoglycerate kinase activity
IT972_RS07745	COG0739	heme binding
IT972_RS07750	COG2833	Protein of unknown function (DUF455)
IT972_RS07755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IT972_RS07765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IT972_RS07770	COG2814	Major facilitator Superfamily
IT972_RS07780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT972_RS07785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IT972_RS07825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IT972_RS07845	COG2354	Protein conserved in bacteria
IT972_RS07855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IT972_RS07870	COG3895	Periplasmic Protein
IT972_RS07875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IT972_RS07890	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IT972_RS07915	COG2885	chlorophyll binding
IT972_RS07920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IT972_RS07940	COG0175	sulfate reduction
IT972_RS07945	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IT972_RS07955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IT972_RS07955	COG1648	precorrin-2 dehydrogenase activity
IT972_RS07960	COG1522	sequence-specific DNA binding
IT972_RS07980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IT972_RS07985	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IT972_RS07990	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IT972_RS07995	COG0149	triose-phosphate isomerase activity
IT972_RS08000	COG0316	Belongs to the HesB IscA family
IT972_RS08010	COG2151	metal-sulfur cluster biosynthetic enzyme
IT972_RS08015	COG4067	protein conserved in archaea
IT972_RS08015	COG0189	ligase activity
IT972_RS08020	COG0343	queuine tRNA-ribosyltransferase activity
IT972_RS08025	COG1902	pentaerythritol trinitrate reductase activity
IT972_RS08030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IT972_RS08035	COG0776	regulation of translation
IT972_RS08045	COG1024	Enoyl-CoA hydratase
IT972_RS08050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IT972_RS08055	COG1116	anion transmembrane transporter activity
IT972_RS08060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IT972_RS08065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IT972_RS08070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IT972_RS08080	COG2022	thiamine diphosphate biosynthetic process
IT972_RS08095	COG0351	phosphomethylpyrimidine kinase
IT972_RS08130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IT972_RS08135	COG1268	BioY protein
IT972_RS08145	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IT972_RS08155	COG1174	glycine betaine transport
IT972_RS08160	COG1125	glycine betaine transport
IT972_RS08165	COG1174	glycine betaine transport
IT972_RS08170	COG1732	Glycine betaine
IT972_RS08180	COG1473	amidohydrolase
IT972_RS08200	COG4681	YaeQ
IT972_RS08250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IT972_RS08265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IT972_RS08270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IT972_RS08280	COG1217	gtp-binding protein TYPA
IT972_RS08285	COG0668	transmembrane transport
IT972_RS08290	COG2076	Multidrug Resistance protein
IT972_RS08300	COG0538	isocitrate dehydrogenase activity
IT972_RS08315	COG2945	thiolester hydrolase activity
IT972_RS08320	COG1959	2 iron, 2 sulfur cluster binding
IT972_RS08330	COG0719	Fe-S assembly protein
IT972_RS08345	COG0396	ATPase activity
IT972_RS08350	COG0719	Fe-S assembly protein
IT972_RS08365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IT972_RS08375	COG2198	Histidine kinase
IT972_RS08375	COG2205	protein histidine kinase activity
IT972_RS08375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT972_RS08375	COG0784	Response regulator, receiver
IT972_RS08385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IT972_RS08395	COG0248	Ppx GppA phosphatase
IT972_RS08400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IT972_RS08405	COG2111	Na H antiporter
IT972_RS08405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IT972_RS08410	COG1006	Multisubunit Na H antiporter MnhC subunit
IT972_RS08415	COG0651	ATP synthesis coupled electron transport
IT972_RS08420	COG1863	multisubunit Na H antiporter MnhE subunit
IT972_RS08425	COG2212	antiporter activity
IT972_RS08430	COG1320	monovalent cation:proton antiporter activity
IT972_RS08445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT972_RS08450	COG0156	8-amino-7-oxononanoate synthase activity
IT972_RS08460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IT972_RS08485	COG0436	Aminotransferase
IT972_RS08495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IT972_RS08500	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IT972_RS08520	COG0440	acetolactate synthase activity
IT972_RS08525	COG0028	Belongs to the TPP enzyme family
IT972_RS08540	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IT972_RS08555	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IT972_RS08570	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IT972_RS08600	COG1764	response to oxidative stress
IT972_RS08630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT972_RS08640	COG0010	Belongs to the arginase family
IT972_RS08655	COG1238	metal cluster binding
IT972_RS08685	COG1175	transmembrane transport
IT972_RS08715	COG4536	flavin adenine dinucleotide binding
IT972_RS08725	COG4974	Belongs to the 'phage' integrase family
IT972_RS08740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IT972_RS08745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IT972_RS08750	COG0629	single-stranded DNA binding
IT972_RS08755	COG0739	heme binding
IT972_RS08755	COG0741	lytic transglycosylase activity
IT972_RS08755	COG1196	nuclear chromosome segregation
IT972_RS08770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT972_RS08775	COG0601	transmembrane transport
IT972_RS08785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IT972_RS08790	COG0528	UMP kinase activity
IT972_RS08795	COG0233	cytoplasmic translational termination
IT972_RS08800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IT972_RS08810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IT972_RS08815	COG0750	zinc metalloprotease
IT972_RS08820	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT972_RS08830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IT972_RS08835	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT972_RS08840	COG3494	Protein of unknown function (DUF1009)
IT972_RS08845	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT972_RS08850	COG0482	sulfurtransferase activity
IT972_RS08865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IT972_RS08870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IT972_RS08880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IT972_RS08885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT972_RS08890	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IT972_RS08910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IT972_RS08915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IT972_RS08920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IT972_RS08925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IT972_RS08930	COG1309	transcriptional regulator
IT972_RS08935	COG2326	polyphosphate kinase activity
IT972_RS08940	COG0596	Alpha beta hydrolase
IT972_RS08945	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IT972_RS08960	COG0697	spore germination
IT972_RS08965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IT972_RS08965	COG0519	Catalyzes the synthesis of GMP from XMP
IT972_RS08970	COG5598	trimethylamine methyltransferase
IT972_RS08985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IT972_RS08995	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IT972_RS09000	COG2867	negative regulation of translational initiation
IT972_RS09005	COG0004	ammonium transporteR
IT972_RS09010	COG1546	Belongs to the CinA family
IT972_RS09015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IT972_RS09020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IT972_RS09020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IT972_RS09025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IT972_RS09030	COG3852	Histidine kinase
IT972_RS09035	COG2204	response regulator
IT972_RS09040	COG5000	phosphorelay sensor kinase activity
IT972_RS09045	COG2204	response regulator
IT972_RS09055	COG0569	domain protein
IT972_RS09065	COG1923	regulation of RNA biosynthetic process
IT972_RS09070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IT972_RS09090	COG2084	Dehydrogenase
IT972_RS09110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IT972_RS09120	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IT972_RS09135	COG3956	TIGRFAM MazG family protein
IT972_RS09140	COG1473	amidohydrolase
IT972_RS09145	COG0010	Belongs to the arginase family
IT972_RS09160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IT972_RS09165	COG2890	protein-(glutamine-N5) methyltransferase activity
IT972_RS09175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IT972_RS09180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IT972_RS09185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IT972_RS09190	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IT972_RS09205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IT972_RS09215	COG3577	Aspartyl protease
IT972_RS09220	COG2095	MarC family integral membrane protein
IT972_RS09225	COG0488	(ABC) transporter
IT972_RS09230	COG0105	UTP biosynthetic process
IT972_RS09265	COG1126	abc transporter atp-binding protein
IT972_RS09275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IT972_RS09280	COG1176	ABC-type spermidine putrescine transport system, permease component I
IT972_RS09295	COG0588	phosphoglycerate mutase activity
IT972_RS09320	COG3743	rRNA binding
IT972_RS09320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IT972_RS09325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IT972_RS09345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IT972_RS09350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IT972_RS09355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IT972_RS09380	COG0052	Belongs to the universal ribosomal protein uS2 family
IT972_RS09385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IT972_RS09390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IT972_RS09400	COG0179	Fumarylacetoacetate (FAA) hydrolase
IT972_RS09405	COG0745	RESPONSE REGULATOR receiver
IT972_RS09415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IT972_RS09425	COG0573	inorganic phosphate transmembrane transporter activity
IT972_RS09435	COG5002	protein histidine kinase activity
IT972_RS09445	COG0194	GDP metabolic process
IT972_RS09450	COG1561	YicC-like family, N-terminal region
IT972_RS09460	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IT972_RS09470	COG2133	pyrroloquinoline quinone binding
IT972_RS09510	COG0433	COG0433 Predicted ATPase
IT972_RS09530	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IT972_RS09535	COG3409	Peptidoglycan-binding domain 1 protein
IT972_RS09535	COG3267	Type II secretory pathway component ExeA
IT972_RS09545	COG1238	metal cluster binding
IT972_RS09555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IT972_RS09560	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IT972_RS09560	COG3264	Mechanosensitive ion channel
IT972_RS09570	COG0494	nUDIX hydrolase
IT972_RS09580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IT972_RS09585	COG0415	Belongs to the DNA photolyase family
IT972_RS09590	COG0604	alcohol dehydrogenase
IT972_RS09620	COG0114	fumarate hydratase activity
IT972_RS09635	COG3588	fructose-bisphosphate aldolase
IT972_RS09650	COG0785	Cytochrome C biogenesis protein
IT972_RS09655	COG0425	Belongs to the sulfur carrier protein TusA family
IT972_RS09660	COG1530	ribonuclease E activity
IT972_RS09680	COG0047	phosphoribosylformylglycinamidine synthase activity
IT972_RS09685	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IT972_RS09690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IT972_RS09695	COG1410	methionine synthase
IT972_RS09695	COG0646	methionine synthase
IT972_RS09705	COG5012	cobalamin binding
IT972_RS09715	COG2166	iron-sulfur cluster assembly
IT972_RS09725	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IT972_RS09730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IT972_RS09735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IT972_RS09745	COG2205	protein histidine kinase activity
IT972_RS09745	COG2202	Pas domain
IT972_RS09750	COG1012	belongs to the aldehyde dehydrogenase family
IT972_RS09760	COG0754	glutathionylspermidine amidase activity
IT972_RS09770	COG0702	epimerase
IT972_RS09775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IT972_RS09780	COG0720	synthase
IT972_RS09785	COG0602	queuosine metabolic process
IT972_RS09790	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IT972_RS09795	COG0318	PFAM AMP-dependent synthetase and ligase
IT972_RS09810	COG0166	Belongs to the GPI family
IT972_RS09815	COG0363	glucosamine-6-phosphate deaminase activity
IT972_RS09820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IT972_RS09835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IT972_RS09845	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IT972_RS09850	COG1612	heme a metabolic process
IT972_RS09875	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IT972_RS09875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IT972_RS09880	COG2313	pseudouridylate synthase activity
IT972_RS09895	COG1028	Short-chain dehydrogenase reductase Sdr
IT972_RS09900	COG4166	transmembrane transport
IT972_RS09925	COG2814	Major facilitator Superfamily
IT972_RS09930	COG0513	Belongs to the DEAD box helicase family
IT972_RS09945	COG0148	phosphopyruvate hydratase activity
IT972_RS09955	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IT972_RS09960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IT972_RS09965	COG0488	(ABC) transporter
IT972_RS09985	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IT972_RS09990	COG0416	fatty acid biosynthetic process
IT972_RS09995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IT972_RS10000	COG0776	regulation of translation
IT972_RS10015	COG0717	Belongs to the dCTP deaminase family
IT972_RS10025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IT972_RS10030	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IT972_RS10035	COG1472	Belongs to the glycosyl hydrolase 3 family
IT972_RS10045	COG0018	arginyl-trna synthetase
IT972_RS10050	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IT972_RS10055	COG0316	Belongs to the HesB IscA family
IT972_RS10095	COG2814	Major facilitator Superfamily
IT972_RS10105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IT972_RS10110	COG0215	cysteine-tRNA ligase activity
IT972_RS10125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IT972_RS10140	COG1522	sequence-specific DNA binding
IT972_RS10145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IT972_RS10160	COG1278	Cold shock
IT972_RS10165	COG0259	pyridoxamine-phosphate oxidase activity
IT972_RS10170	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IT972_RS10175	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IT972_RS10190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IT972_RS10210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IT972_RS10215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IT972_RS10220	COG0134	indole-3-glycerol-phosphate synthase activity
IT972_RS10225	COG0315	cyclic pyranopterin monophosphate synthase activity
IT972_RS10230	COG0303	'Molybdopterin
IT972_RS10235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IT972_RS10240	COG2333	competence protein COMEC
IT972_RS10240	COG0658	competence protein
IT972_RS10245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IT972_RS10250	COG0372	Belongs to the citrate synthase family
IT972_RS10260	COG1024	Enoyl-CoA hydratase
IT972_RS10265	COG3088	subunit of a heme lyase
IT972_RS10270	COG1138	Cytochrome C-type biogenesis protein
IT972_RS10285	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IT972_RS10290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IT972_RS10295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IT972_RS10315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IT972_RS10325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IT972_RS10335	COG0418	dihydroorotase activity
IT972_RS10340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IT972_RS10345	COG0305	Participates in initiation and elongation during chromosome replication
IT972_RS10360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IT972_RS10385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IT972_RS10395	COG4221	oxidoreductase activity
IT972_RS10400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IT972_RS10405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IT972_RS10420	COG0805	protein transport
IT972_RS10425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT972_RS10430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IT972_RS10440	COG3842	ATPase activity
IT972_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
IT972_RS10465	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IT972_RS10475	COG0513	Belongs to the DEAD box helicase family
IT972_RS10485	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IT972_RS10495	COG1007	ATP synthesis coupled electron transport
IT972_RS10510	COG0713	ATP synthesis coupled electron transport
IT972_RS10525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT972_RS10530	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IT972_RS10570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IT972_RS10570	COG3743	rRNA binding
IT972_RS10580	COG0649	NAD binding
IT972_RS10590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT972_RS10595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IT972_RS10605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IT972_RS10610	COG1024	Enoyl-CoA hydratase
IT972_RS10630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IT972_RS10635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT972_RS10645	COG1960	acyl-CoA dehydrogenase activity
IT972_RS10655	COG0346	lactoylglutathione lyase activity
IT972_RS10660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IT972_RS10665	COG0546	phosphoglycolate phosphatase activity
IT972_RS10670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IT972_RS10690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IT972_RS10695	COG1519	Transferase
IT972_RS10700	COG0438	transferase activity, transferring glycosyl groups
IT972_RS10705	COG1473	amidohydrolase
IT972_RS10710	COG1473	amidohydrolase
IT972_RS10715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IT972_RS10720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IT972_RS10725	COG4172	Belongs to the ABC transporter superfamily
IT972_RS10735	COG0601	transmembrane transport
IT972_RS10740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IT972_RS10755	COG3453	Protein conserved in bacteria
IT972_RS10755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT972_RS10760	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IT972_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
IT972_RS10785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IT972_RS10800	COG0308	aminopeptidase N
IT972_RS10820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IT972_RS10840	COG0484	heat shock protein binding
IT972_RS10855	COG0006	proline dipeptidase activity
IT972_RS10880	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IT972_RS10890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IT972_RS10895	COG0849	cell division
IT972_RS10900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IT972_RS10905	COG1181	Belongs to the D-alanine--D-alanine ligase family
IT972_RS10910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IT972_RS10930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IT972_RS10935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IT972_RS10950	COG2081	HI0933 family
IT972_RS10965	COG1231	oxidoreductase activity
IT972_RS10990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IT972_RS10995	COG2066	Belongs to the glutaminase family
IT972_RS11000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IT972_RS11010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IT972_RS11025	COG0275	rRNA processing
IT972_RS11030	COG2001	Belongs to the MraZ family
IT972_RS11035	COG0489	protein tyrosine kinase activity
IT972_RS11050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IT972_RS11055	COG0346	lactoylglutathione lyase activity
IT972_RS11065	COG1610	YqeY-like protein
IT972_RS11070	COG0505	Belongs to the CarA family
IT972_RS11080	COG1802	Transcriptional regulator
IT972_RS11090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IT972_RS11100	COG1522	sequence-specific DNA binding
IT972_RS11110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IT972_RS11120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IT972_RS11125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IT972_RS11130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IT972_RS11140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IT972_RS11140	COG0574	Belongs to the PEP-utilizing enzyme family
IT972_RS11145	COG0751	glycine-tRNA ligase activity
IT972_RS11155	COG0752	glycyl-tRNA synthetase alpha subunit
IT972_RS11170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IT972_RS11180	COG1469	GTP cyclohydrolase I activity
IT972_RS11190	COG2917	probably involved in intracellular septation
IT972_RS11200	COG0552	protein localization to endoplasmic reticulum
IT972_RS11210	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IT972_RS11225	COG1570	exodeoxyribonuclease VII activity
IT972_RS11250	COG1120	ATPase activity
IT972_RS11255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IT972_RS11260	COG0628	permease
IT972_RS11280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IT972_RS11300	COG0729	surface antigen
IT972_RS11325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IT972_RS11345	COG0321	lipoyl(octanoyl) transferase activity
IT972_RS11380	COG0131	Imidazoleglycerol-phosphate dehydratase
IT972_RS11385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IT972_RS11400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IT972_RS11405	COG0107	imidazoleglycerol-phosphate synthase activity
IT972_RS11410	COG0140	phosphoribosyl-ATP diphosphatase activity
IT972_RS11415	COG1832	CoA-binding protein
IT972_RS11425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IT972_RS11440	COG2873	o-acetylhomoserine
IT972_RS11470	COG1329	Transcriptional regulator
IT972_RS11475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IT972_RS11480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IT972_RS11500	COG2267	carboxylic ester hydrolase activity
IT972_RS11510	COG1793	dna ligase
IT972_RS11520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IT972_RS11535	COG0564	pseudouridine synthase activity
IT972_RS11570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IT972_RS11575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IT972_RS11580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT972_RS11580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IT972_RS11610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT972_RS11610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IT972_RS11615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IT972_RS11620	COG4221	oxidoreductase activity
IT972_RS11625	COG0432	Pfam Uncharacterised protein family UPF0047
IT972_RS11640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IT972_RS11645	COG0358	DNA primase activity
IT972_RS11655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IT972_RS11715	COG0824	Thioesterase
IT972_RS11715	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT972_RS11725	COG3246	L-lysine catabolic process to acetate
IT972_RS11730	COG0667	Aldo Keto reductase
IT972_RS11740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT972_RS11745	COG5002	protein histidine kinase activity
IT972_RS11755	COG1522	sequence-specific DNA binding
IT972_RS11775	COG0483	inositol monophosphate 1-phosphatase activity
IT972_RS11780	COG2130	NADP-dependent
IT972_RS11795	COG0583	DNA-binding transcription factor activity
IT972_RS11815	COG0525	valine-tRNA ligase activity
IT972_RS11825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IT972_RS11840	COG1132	(ABC) transporter
IT972_RS11850	COG0354	folic acid binding
IT972_RS11855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IT972_RS11905	COG0582	viral genome integration into host DNA
IT972_RS11910	COG4999	Histidine kinase
IT972_RS11910	COG3437	response regulator, receiver
IT972_RS11910	COG3850	Histidine kinase
IT972_RS11910	COG2205	protein histidine kinase activity
IT972_RS12040	COG1475	DNA binding
IT972_RS12100	COG0582	viral genome integration into host DNA
IT972_RS12130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IT972_RS12140	COG1454	alcohol dehydrogenase
IT972_RS12150	COG0527	aspartate kinase activity
IT972_RS12165	COG0725	ABC transporter, periplasmic molybdate-binding protein
IT972_RS12170	COG4149	molybdate abc transporter
IT972_RS12195	COG0659	secondary active sulfate transmembrane transporter activity
IT972_RS12200	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IT972_RS12205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IT972_RS12245	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IT972_RS12250	COG0135	phosphoribosylanthranilate isomerase activity
IT972_RS12260	COG0776	regulation of translation
IT972_RS12265	COG0539	negative regulation of cytoplasmic translation
IT972_RS12275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IT972_RS12280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IT972_RS12285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IT972_RS12290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IT972_RS12295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IT972_RS12300	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IT972_RS12305	COG1253	flavin adenine dinucleotide binding
IT972_RS12310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IT972_RS12315	COG1702	phosphate starvation-inducible protein PhoH
IT972_RS12330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IT972_RS12345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IT972_RS12350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IT972_RS12355	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IT972_RS12365	COG1047	Peptidyl-prolyl cis-trans
IT972_RS12385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IT972_RS12410	COG4948	Mandelate Racemase Muconate Lactonizing
IT972_RS12415	COG1960	acyl-CoA dehydrogenase activity
IT972_RS12420	COG0583	DNA-binding transcription factor activity
IT972_RS12430	COG0737	Belongs to the 5'-nucleotidase family
IT972_RS12450	COG0534	Mate efflux family protein
IT972_RS12475	COG2197	response regulator
IT972_RS12480	COG0789	Transcriptional regulator
IT972_RS12485	COG1960	acyl-CoA dehydrogenase activity
IT972_RS12495	COG0625	glutathione transferase activity
IT972_RS12500	COG0183	Belongs to the thiolase family
IT972_RS12520	COG0318	PFAM AMP-dependent synthetase and ligase
IT972_RS12540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IT972_RS12545	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IT972_RS12560	COG0280	phosphate acetyltransferase
IT972_RS12560	COG0281	malic enzyme
IT972_RS12575	COG3237	CsbD-like
IT972_RS12580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IT972_RS12585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IT972_RS12595	COG0596	Alpha beta hydrolase
IT972_RS12600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IT972_RS12610	COG1435	thymidine kinase activity
IT972_RS12620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IT972_RS12640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IT972_RS12650	COG1496	oxidoreductase activity
IT972_RS12665	COG1522	sequence-specific DNA binding
IT972_RS12670	COG0492	ferredoxin-NADP+ reductase activity
IT972_RS12675	COG0529	Catalyzes the synthesis of activated sulfate
IT972_RS12675	COG2046	Belongs to the sulfate adenylyltransferase family
IT972_RS12700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IT972_RS12705	COG3454	Phosphonate metabolism
IT972_RS12725	COG0459	protein refolding
IT972_RS12730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IT972_RS12740	COG1227	inorganic diphosphatase activity
IT972_RS12760	COG2030	dehydratase
IT972_RS12765	COG0196	riboflavin kinase activity
IT972_RS12770	COG2983	Belongs to the UPF0260 family
IT972_RS12800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IT972_RS12805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IT972_RS12810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IT972_RS12815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IT972_RS12820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IT972_RS12830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IT972_RS12855	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IT972_RS12870	COG0287	Prephenate dehydrogenase
IT972_RS12875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IT972_RS12880	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IT972_RS12885	COG0745	RESPONSE REGULATOR receiver
IT972_RS12890	COG0519	Catalyzes the synthesis of GMP from XMP
IT972_RS12915	COG2890	protein-(glutamine-N5) methyltransferase activity
IT972_RS12925	COG0142	geranyltranstransferase activity
IT972_RS12930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IT972_RS12945	COG0789	Transcriptional regulator
IT972_RS12955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IT972_RS12965	COG0303	'Molybdopterin
IT972_RS12975	COG0746	molybdenum cofactor guanylyltransferase activity
IT972_RS13015	COG1960	acyl-CoA dehydrogenase activity
IT972_RS13020	COG0009	L-threonylcarbamoyladenylate synthase
IT972_RS13025	COG1678	Uncharacterized ACR, COG1678
IT972_RS13035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IT972_RS13045	COG0521	Mo-molybdopterin cofactor biosynthetic process
IT972_RS13050	COG1280	lysine exporter protein (LysE YggA)
IT972_RS13055	COG1573	uracil-dna glycosylase
IT972_RS13060	COG0540	Belongs to the ATCase OTCase family
IT972_RS13085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IT972_RS13105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IT972_RS13110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IT972_RS13115	COG2885	chlorophyll binding
IT972_RS13125	COG0314	molybdopterin synthase activity
IT972_RS13135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IT972_RS13140	COG0322	excinuclease ABC activity
IT972_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
IT972_RS13160	COG0842	Transport permease protein
IT972_RS13165	COG1131	(ABC) transporter
IT972_RS13175	COG3321	synthase
IT972_RS13175	COG0604	alcohol dehydrogenase
IT972_RS13175	COG1028	Short-chain dehydrogenase reductase Sdr
IT972_RS13185	COG1294	oxidase, subunit
IT972_RS13190	COG1271	oxidase subunit
IT972_RS13195	COG2205	protein histidine kinase activity
IT972_RS13215	COG1012	belongs to the aldehyde dehydrogenase family
IT972_RS13220	COG0174	glutamine synthetase
IT972_RS13250	COG0019	diaminopimelate decarboxylase activity
IT972_RS13265	COG2205	protein histidine kinase activity
IT972_RS13270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IT972_RS13280	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IT972_RS13285	COG0594	ribonuclease P activity
IT972_RS13290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IT972_RS13295	COG0037	tRNA processing
IT972_RS13305	COG0706	membrane insertase activity
IT972_RS13310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IT972_RS13315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IT972_RS13325	COG1126	abc transporter atp-binding protein
IT972_RS13330	COG0765	amino acid transport
IT972_RS13335	COG4597	amino acid ABC transporter
IT972_RS13340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IT972_RS13355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IT972_RS13360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IT972_RS13365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IT972_RS13370	COG0203	ribosomal protein L17
IT972_RS13375	COG0202	RNA polymerase activity
IT972_RS13380	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IT972_RS13385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IT972_RS13390	COG0563	adenylate kinase activity
IT972_RS13395	COG0201	protein transport
IT972_RS13400	COG0200	Binds to the 23S rRNA
IT972_RS13405	COG1841	ribosomal large subunit assembly
IT972_RS13410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IT972_RS13415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IT972_RS13420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IT972_RS13425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IT972_RS13430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IT972_RS13435	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IT972_RS13440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IT972_RS13445	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IT972_RS13450	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IT972_RS13455	COG0255	Belongs to the universal ribosomal protein uL29 family
IT972_RS13475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IT972_RS13480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IT972_RS13485	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IT972_RS13490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IT972_RS13495	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IT972_RS13505	COG0089	rRNA binding
IT972_RS13510	COG0088	Forms part of the polypeptide exit tunnel
IT972_RS13515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IT972_RS13520	COG0051	transcription antitermination factor activity, RNA binding
IT972_RS13530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IT972_RS13535	COG0049	tRNA binding
IT972_RS13540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IT972_RS13550	COG0697	spore germination
IT972_RS13555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IT972_RS13560	COG0085	RNA polymerase activity
IT972_RS13565	COG0222	ribosome binding
IT972_RS13570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IT972_RS13575	COG0081	regulation of translation
IT972_RS13580	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IT972_RS13585	COG0250	Participates in transcription elongation, termination and antitermination
IT972_RS13600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IT972_RS13625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IT972_RS13635	COG0300	oxidoreductase activity
IT972_RS13645	COG2096	Adenosyltransferase
IT972_RS13665	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT972_RS13675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IT972_RS13685	COG1660	Displays ATPase and GTPase activities
IT972_RS13695	COG2205	protein histidine kinase activity
IT972_RS13700	COG0745	RESPONSE REGULATOR receiver
IT972_RS13705	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IT972_RS13720	COG1396	sequence-specific DNA binding
IT972_RS13740	COG1381	Involved in DNA repair and RecF pathway recombination
IT972_RS13750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IT972_RS13755	COG0571	ribonuclease III activity
IT972_RS13760	COG0681	Belongs to the peptidase S26 family
IT972_RS13765	COG0736	holo-[acyl-carrier-protein] synthase activity
IT972_RS13770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IT972_RS13780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IT972_RS13785	COG1758	RNA polymerase activity
IT972_RS13790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IT972_RS13800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IT972_RS13810	COG0328	RNA-DNA hybrid ribonuclease activity
IT972_RS13815	COG2860	membrane
IT972_RS13825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IT972_RS13830	COG0242	peptide deformylase activity
IT972_RS13835	COG0242	peptide deformylase activity
IT972_RS13840	COG0242	peptide deformylase activity
IT972_RS13845	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IT972_RS13855	COG0435	Glutathione S-transferase
IT972_RS13875	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IT972_RS13880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IT972_RS13885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IT972_RS13890	COG0356	it plays a direct role in the translocation of protons across the membrane
IT972_RS13915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IT972_RS13920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IT972_RS13930	COG0228	four-way junction DNA binding
IT972_RS13935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IT972_RS13940	COG0336	Belongs to the RNA methyltransferase TrmD family
IT972_RS13945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IT972_RS13950	COG0335	large ribosomal subunit rRNA binding
IT972_RS13955	COG0254	rRNA binding
IT972_RS13965	COG2151	metal-sulfur cluster biosynthetic enzyme
IT972_RS13965	COG0489	protein tyrosine kinase activity
IT972_RS13975	COG0179	Fumarylacetoacetate (FAA) hydrolase
IT972_RS14005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IT972_RS14010	COG0181	hydroxymethylbilane synthase activity
IT972_RS14015	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IT972_RS14020	COG0408	coproporphyrinogen oxidase activity
IT972_RS14025	COG1028	Short-chain dehydrogenase reductase Sdr
IT972_RS14035	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IT972_RS14045	COG1686	Belongs to the peptidase S11 family
IT972_RS14050	COG4172	Belongs to the ABC transporter superfamily
IT972_RS14055	COG4239	(ABC) transporter, permease
IT972_RS14060	COG4174	ABC transporter (Permease)
IT972_RS14075	COG0077	Prephenate dehydratase
IT972_RS14085	COG2816	NAD+ diphosphatase activity
IT972_RS14095	COG2321	neutral zinc metallopeptidase
IT972_RS14105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IT972_RS14115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IT972_RS14120	COG1250	3-hydroxyacyl-CoA dehydrogenase
IT972_RS14150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IT972_RS14160	COG1268	BioY protein
IT972_RS14165	COG1492	cobalamin metabolic process
IT972_RS14205	COG2099	Precorrin-6x reductase
IT972_RS14220	COG2875	Belongs to the precorrin methyltransferase family
IT972_RS14225	COG1797	cobyrinic acid a,c-diamide synthase activity
IT972_RS14230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IT972_RS14230	COG1648	precorrin-2 dehydrogenase activity
IT972_RS14250	COG2217	Heavy metal translocating P-type atpase
IT972_RS14260	COG1216	Glycosyl transferase, family 2
IT972_RS14275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IT972_RS14280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IT972_RS14285	COG1063	alcohol dehydrogenase
IT972_RS14290	COG0156	8-amino-7-oxononanoate synthase activity
IT972_RS14295	COG1396	sequence-specific DNA binding
IT972_RS14300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IT972_RS14305	COG2226	methyltransferase
IT972_RS14310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IT972_RS14315	COG1024	Enoyl-CoA hydratase
IT972_RS14320	COG0268	Binds directly to 16S ribosomal RNA