locus-tag	class	description
E5180_RS00010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5180_RS00020	COG0051	transcription antitermination factor activity, RNA binding
E5180_RS00025	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5180_RS00030	COG0088	Forms part of the polypeptide exit tunnel
E5180_RS00035	COG0089	rRNA binding
E5180_RS00045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5180_RS00050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5180_RS00055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5180_RS00060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5180_RS00065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5180_RS00085	COG0255	Belongs to the universal ribosomal protein uL29 family
E5180_RS00090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5180_RS00095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5180_RS00100	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E5180_RS00105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5180_RS00110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5180_RS00115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5180_RS00120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5180_RS00125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5180_RS00130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5180_RS00135	COG1841	ribosomal large subunit assembly
E5180_RS00140	COG0200	Binds to the 23S rRNA
E5180_RS00145	COG0201	protein transport
E5180_RS00150	COG0563	adenylate kinase activity
E5180_RS00155	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5180_RS00160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5180_RS00165	COG0202	RNA polymerase activity
E5180_RS00170	COG0203	ribosomal protein L17
E5180_RS00175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5180_RS00180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5180_RS00185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5180_RS00200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5180_RS00205	COG4597	amino acid ABC transporter
E5180_RS00210	COG0765	amino acid transport
E5180_RS00215	COG1126	abc transporter atp-binding protein
E5180_RS00225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5180_RS00230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5180_RS00240	COG0706	membrane insertase activity
E5180_RS00250	COG0037	tRNA processing
E5180_RS00255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5180_RS00260	COG0594	ribonuclease P activity
E5180_RS00265	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5180_RS00275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5180_RS00280	COG2205	protein histidine kinase activity
E5180_RS00295	COG0019	diaminopimelate decarboxylase activity
E5180_RS00325	COG0174	glutamine synthetase
E5180_RS00330	COG1012	belongs to the aldehyde dehydrogenase family
E5180_RS00350	COG2205	protein histidine kinase activity
E5180_RS00355	COG1271	oxidase subunit
E5180_RS00360	COG1294	oxidase, subunit
E5180_RS00370	COG3321	synthase
E5180_RS00370	COG1028	Short-chain dehydrogenase reductase Sdr
E5180_RS00370	COG0604	alcohol dehydrogenase
E5180_RS00385	COG1131	(ABC) transporter
E5180_RS00390	COG0842	Transport permease protein
E5180_RS00405	COG1028	Short-chain dehydrogenase reductase Sdr
E5180_RS00410	COG0322	excinuclease ABC activity
E5180_RS00415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5180_RS00425	COG0314	molybdopterin synthase activity
E5180_RS00435	COG2885	chlorophyll binding
E5180_RS00465	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E5180_RS00490	COG0540	Belongs to the ATCase OTCase family
E5180_RS00495	COG1573	uracil-dna glycosylase
E5180_RS00500	COG1280	lysine exporter protein (LysE YggA)
E5180_RS00505	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5180_RS00525	COG1678	Uncharacterized ACR, COG1678
E5180_RS00530	COG0009	L-threonylcarbamoyladenylate synthase
E5180_RS00535	COG1960	acyl-CoA dehydrogenase activity
E5180_RS00585	COG0303	'Molybdopterin
E5180_RS00595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5180_RS00615	COG0142	geranyltranstransferase activity
E5180_RS00625	COG2890	protein-(glutamine-N5) methyltransferase activity
E5180_RS00650	COG0519	Catalyzes the synthesis of GMP from XMP
E5180_RS00655	COG0745	RESPONSE REGULATOR receiver
E5180_RS00660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5180_RS00665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5180_RS00670	COG0287	Prephenate dehydrogenase
E5180_RS00680	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E5180_RS00695	COG1196	nuclear chromosome segregation
E5180_RS00695	COG0739	heme binding
E5180_RS00695	COG0741	lytic transglycosylase activity
E5180_RS00705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5180_RS00715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5180_RS00720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5180_RS00725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5180_RS00730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5180_RS00735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5180_RS00765	COG2983	Belongs to the UPF0260 family
E5180_RS00770	COG0196	riboflavin kinase activity
E5180_RS00775	COG2030	dehydratase
E5180_RS00795	COG1227	inorganic diphosphatase activity
E5180_RS00805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5180_RS00810	COG0459	protein refolding
E5180_RS00830	COG3454	Phosphonate metabolism
E5180_RS00835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5180_RS00860	COG0529	Catalyzes the synthesis of activated sulfate
E5180_RS00860	COG2046	Belongs to the sulfate adenylyltransferase family
E5180_RS00865	COG0492	ferredoxin-NADP+ reductase activity
E5180_RS00870	COG1522	sequence-specific DNA binding
E5180_RS00880	COG1496	oxidoreductase activity
E5180_RS00890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5180_RS00910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5180_RS00920	COG1435	thymidine kinase activity
E5180_RS00930	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5180_RS00935	COG0596	Alpha beta hydrolase
E5180_RS00945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5180_RS00950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5180_RS00955	COG3237	CsbD-like
E5180_RS00970	COG0281	malic enzyme
E5180_RS00970	COG0280	phosphate acetyltransferase
E5180_RS00980	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E5180_RS00985	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E5180_RS00990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5180_RS01010	COG0318	PFAM AMP-dependent synthetase and ligase
E5180_RS01030	COG0183	Belongs to the thiolase family
E5180_RS01035	COG0625	glutathione transferase activity
E5180_RS01045	COG1960	acyl-CoA dehydrogenase activity
E5180_RS01050	COG0789	Transcriptional regulator
E5180_RS01055	COG2197	response regulator
E5180_RS01080	COG0534	Mate efflux family protein
E5180_RS01100	COG0737	Belongs to the 5'-nucleotidase family
E5180_RS01110	COG0583	DNA-binding transcription factor activity
E5180_RS01115	COG1960	acyl-CoA dehydrogenase activity
E5180_RS01130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5180_RS01150	COG1047	Peptidyl-prolyl cis-trans
E5180_RS01160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5180_RS01165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5180_RS01170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5180_RS01185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5180_RS01190	COG2885	chlorophyll binding
E5180_RS01200	COG1702	phosphate starvation-inducible protein PhoH
E5180_RS01205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5180_RS01210	COG1253	flavin adenine dinucleotide binding
E5180_RS01215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E5180_RS01220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5180_RS01225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5180_RS01230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5180_RS01235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5180_RS01245	COG0539	negative regulation of cytoplasmic translation
E5180_RS01250	COG0776	regulation of translation
E5180_RS01260	COG0135	phosphoribosylanthranilate isomerase activity
E5180_RS01265	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E5180_RS01295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5180_RS01300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E5180_RS01305	COG0659	secondary active sulfate transmembrane transporter activity
E5180_RS01325	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E5180_RS01330	COG4149	molybdate abc transporter
E5180_RS01335	COG0725	ABC transporter, periplasmic molybdate-binding protein
E5180_RS01350	COG0527	aspartate kinase activity
E5180_RS01355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5180_RS01360	COG1454	alcohol dehydrogenase
E5180_RS01370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5180_RS01395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5180_RS01415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5180_RS01420	COG0354	folic acid binding
E5180_RS01430	COG1132	(ABC) transporter
E5180_RS01440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5180_RS01450	COG0525	valine-tRNA ligase activity
E5180_RS01470	COG0583	DNA-binding transcription factor activity
E5180_RS01485	COG2130	NADP-dependent
E5180_RS01490	COG0483	inositol monophosphate 1-phosphatase activity
E5180_RS01510	COG1522	sequence-specific DNA binding
E5180_RS01525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5180_RS01535	COG0667	Aldo Keto reductase
E5180_RS01600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5180_RS01610	COG0358	DNA primase activity
E5180_RS01615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5180_RS01630	COG0432	Pfam Uncharacterised protein family UPF0047
E5180_RS01635	COG4221	oxidoreductase activity
E5180_RS01640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5180_RS01645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5180_RS01645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5180_RS01670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5180_RS01670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5180_RS01675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5180_RS01680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5180_RS01715	COG0564	pseudouridine synthase activity
E5180_RS01725	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E5180_RS01735	COG1793	dna ligase
E5180_RS01745	COG2267	carboxylic ester hydrolase activity
E5180_RS01765	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5180_RS01770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E5180_RS01775	COG1329	Transcriptional regulator
E5180_RS01795	COG2968	Membrane
E5180_RS01800	COG2873	o-acetylhomoserine
E5180_RS01810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5180_RS01815	COG1832	CoA-binding protein
E5180_RS01820	COG0140	phosphoribosyl-ATP diphosphatase activity
E5180_RS01825	COG0107	imidazoleglycerol-phosphate synthase activity
E5180_RS01830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5180_RS01845	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5180_RS01850	COG0131	Imidazoleglycerol-phosphate dehydratase
E5180_RS01885	COG0321	lipoyl(octanoyl) transferase activity
E5180_RS01905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5180_RS01930	COG0729	surface antigen
E5180_RS01950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5180_RS01970	COG0628	permease
E5180_RS01980	COG1120	ATPase activity
E5180_RS02000	COG0151	Belongs to the GarS family
E5180_RS02005	COG1570	exodeoxyribonuclease VII activity
E5180_RS02015	COG3239	Fatty acid desaturase
E5180_RS02020	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E5180_RS02030	COG0552	protein localization to endoplasmic reticulum
E5180_RS02040	COG2917	probably involved in intracellular septation
E5180_RS02050	COG1469	GTP cyclohydrolase I activity
E5180_RS02060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5180_RS02075	COG0752	glycyl-tRNA synthetase alpha subunit
E5180_RS02085	COG0751	glycine-tRNA ligase activity
E5180_RS02090	COG0574	Belongs to the PEP-utilizing enzyme family
E5180_RS02090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5180_RS02100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E5180_RS02105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5180_RS02110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5180_RS02130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5180_RS02140	COG1522	sequence-specific DNA binding
E5180_RS02150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5180_RS02160	COG1802	Transcriptional regulator
E5180_RS02170	COG0505	Belongs to the CarA family
E5180_RS02175	COG1610	YqeY-like protein
E5180_RS02185	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E5180_RS02190	COG0210	DNA helicase
E5180_RS02200	COG0489	protein tyrosine kinase activity
E5180_RS02205	COG2001	Belongs to the MraZ family
E5180_RS02210	COG0275	rRNA processing
E5180_RS02225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5180_RS02235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5180_RS02240	COG2066	Belongs to the glutaminase family
E5180_RS02245	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5180_RS02260	COG2081	HI0933 family
E5180_RS02275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5180_RS02280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5180_RS02300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5180_RS02305	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5180_RS02310	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5180_RS02315	COG0849	cell division
E5180_RS02320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5180_RS02330	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5180_RS02355	COG0006	proline dipeptidase activity
E5180_RS02390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5180_RS02405	COG0308	aminopeptidase N
E5180_RS02420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5180_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
E5180_RS02450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E5180_RS02470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5180_RS02475	COG0601	transmembrane transport
E5180_RS02485	COG4172	Belongs to the ABC transporter superfamily
E5180_RS02490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5180_RS02495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5180_RS02500	COG1473	amidohydrolase
E5180_RS02505	COG1473	amidohydrolase
E5180_RS02510	COG0438	transferase activity, transferring glycosyl groups
E5180_RS02515	COG1519	Transferase
E5180_RS02520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5180_RS02540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5180_RS02545	COG0546	phosphoglycolate phosphatase activity
E5180_RS02560	COG1960	acyl-CoA dehydrogenase activity
E5180_RS02570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5180_RS02575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5180_RS02600	COG1024	Enoyl-CoA hydratase
E5180_RS02610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5180_RS02615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5180_RS02620	COG0649	NAD binding
E5180_RS02630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5180_RS02630	COG3743	rRNA binding
E5180_RS02670	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5180_RS02675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5180_RS02690	COG0713	ATP synthesis coupled electron transport
E5180_RS02705	COG1007	ATP synthesis coupled electron transport
E5180_RS02715	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E5180_RS02725	COG0513	Belongs to the DEAD box helicase family
E5180_RS02735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5180_RS02750	COG1028	Short-chain dehydrogenase reductase Sdr
E5180_RS02760	COG3842	ATPase activity
E5180_RS02770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5180_RS02775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5180_RS02780	COG0805	protein transport
E5180_RS02795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5180_RS02800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5180_RS02805	COG4221	oxidoreductase activity
E5180_RS02815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5180_RS02840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5180_RS02855	COG0305	Participates in initiation and elongation during chromosome replication
E5180_RS02860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5180_RS02865	COG0418	dihydroorotase activity
E5180_RS02875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5180_RS02885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5180_RS02905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5180_RS02910	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5180_RS02915	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E5180_RS02930	COG1138	Cytochrome C-type biogenesis protein
E5180_RS02935	COG3088	subunit of a heme lyase
E5180_RS02940	COG1024	Enoyl-CoA hydratase
E5180_RS02950	COG0372	Belongs to the citrate synthase family
E5180_RS02955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5180_RS02960	COG0658	competence protein
E5180_RS02960	COG2333	competence protein COMEC
E5180_RS02965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5180_RS02970	COG0303	'Molybdopterin
E5180_RS02980	COG0134	indole-3-glycerol-phosphate synthase activity
E5180_RS02985	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5180_RS02990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5180_RS03010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5180_RS03020	COG0436	Aminotransferase
E5180_RS03025	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E5180_RS03030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5180_RS03035	COG0259	pyridoxamine-phosphate oxidase activity
E5180_RS03040	COG1278	Cold shock
E5180_RS03055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5180_RS03100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5180_RS03140	COG1609	Transcriptional regulator
E5180_RS03165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5180_RS03170	COG3920	Histidine kinase
E5180_RS03190	COG0438	transferase activity, transferring glycosyl groups
E5180_RS03210	COG1742	UPF0060 membrane protein
E5180_RS03215	COG0789	Transcriptional regulator
E5180_RS03265	COG2824	Alkylphosphonate utilization operon protein PhnA
E5180_RS03285	COG1522	sequence-specific DNA binding
E5180_RS03300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5180_RS03315	COG0215	cysteine-tRNA ligase activity
E5180_RS03320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5180_RS03330	COG2814	Major facilitator Superfamily
E5180_RS03365	COG1609	Transcriptional regulator
E5180_RS03410	COG0316	Belongs to the HesB IscA family
E5180_RS03415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E5180_RS03420	COG0018	arginyl-trna synthetase
E5180_RS03430	COG1472	Belongs to the glycosyl hydrolase 3 family
E5180_RS03435	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5180_RS03450	COG0717	Belongs to the dCTP deaminase family
E5180_RS03465	COG0776	regulation of translation
E5180_RS03470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5180_RS03475	COG0416	fatty acid biosynthetic process
E5180_RS03480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5180_RS03500	COG0488	(ABC) transporter
E5180_RS03505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5180_RS03510	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E5180_RS03525	COG0148	phosphopyruvate hydratase activity
E5180_RS03540	COG0513	Belongs to the DEAD box helicase family
E5180_RS03545	COG2814	Major facilitator Superfamily
E5180_RS03570	COG4166	transmembrane transport
E5180_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
E5180_RS03585	COG2313	pseudouridylate synthase activity
E5180_RS03590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E5180_RS03590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E5180_RS03605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5180_RS03605	COG0352	thiamine-phosphate diphosphorylase activity
E5180_RS03605	COG0351	phosphomethylpyrimidine kinase
E5180_RS03615	COG1612	heme a metabolic process
E5180_RS03620	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E5180_RS03630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5180_RS03645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E5180_RS03650	COG0363	glucosamine-6-phosphate deaminase activity
E5180_RS03655	COG0166	Belongs to the GPI family
E5180_RS03670	COG0318	PFAM AMP-dependent synthetase and ligase
E5180_RS03675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5180_RS03680	COG0602	queuosine metabolic process
E5180_RS03685	COG0720	synthase
E5180_RS03690	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5180_RS03695	COG0702	epimerase
E5180_RS03705	COG0754	glutathionylspermidine amidase activity
E5180_RS03715	COG2205	protein histidine kinase activity
E5180_RS03715	COG2202	Pas domain
E5180_RS03730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E5180_RS03740	COG1213	nucleotidyl transferase
E5180_RS03765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5180_RS03770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5180_RS03775	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E5180_RS03785	COG2166	iron-sulfur cluster assembly
E5180_RS03795	COG5012	cobalamin binding
E5180_RS03805	COG0646	methionine synthase
E5180_RS03805	COG1410	methionine synthase
E5180_RS03810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5180_RS03815	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5180_RS03820	COG0047	phosphoribosylformylglycinamidine synthase activity
E5180_RS03840	COG1530	ribonuclease E activity
E5180_RS03845	COG0425	Belongs to the sulfur carrier protein TusA family
E5180_RS03850	COG0785	Cytochrome C biogenesis protein
E5180_RS03865	COG3588	fructose-bisphosphate aldolase
E5180_RS03880	COG0114	fumarate hydratase activity
E5180_RS03905	COG0604	alcohol dehydrogenase
E5180_RS03910	COG0415	Belongs to the DNA photolyase family
E5180_RS03915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5180_RS03925	COG0494	nUDIX hydrolase
E5180_RS03935	COG3264	Mechanosensitive ion channel
E5180_RS03935	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E5180_RS03940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5180_RS03950	COG1238	metal cluster binding
E5180_RS03965	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5180_RS03985	COG0433	COG0433 Predicted ATPase
E5180_RS04020	COG2133	pyrroloquinoline quinone binding
E5180_RS04030	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E5180_RS04040	COG1561	YicC-like family, N-terminal region
E5180_RS04045	COG0194	GDP metabolic process
E5180_RS04055	COG5002	protein histidine kinase activity
E5180_RS04065	COG0573	inorganic phosphate transmembrane transporter activity
E5180_RS04075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5180_RS04085	COG0745	RESPONSE REGULATOR receiver
E5180_RS04090	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5180_RS04100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E5180_RS04105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5180_RS04110	COG0052	Belongs to the universal ribosomal protein uS2 family
E5180_RS04135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5180_RS04140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5180_RS04145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5180_RS04160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5180_RS04165	COG3743	rRNA binding
E5180_RS04165	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5180_RS04185	COG1126	abc transporter atp-binding protein
E5180_RS04220	COG0105	UTP biosynthetic process
E5180_RS04225	COG0488	(ABC) transporter
E5180_RS04230	COG2095	MarC family integral membrane protein
E5180_RS04235	COG3577	Aspartyl protease
E5180_RS04245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5180_RS04265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5180_RS04270	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E5180_RS04275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5180_RS04285	COG2890	protein-(glutamine-N5) methyltransferase activity
E5180_RS04290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5180_RS04305	COG0010	Belongs to the arginase family
E5180_RS04310	COG1473	amidohydrolase
E5180_RS04315	COG3956	TIGRFAM MazG family protein
E5180_RS04330	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5180_RS04340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5180_RS04360	COG2084	Dehydrogenase
E5180_RS04380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5180_RS04385	COG1923	regulation of RNA biosynthetic process
E5180_RS04395	COG0569	domain protein
E5180_RS04405	COG2204	response regulator
E5180_RS04410	COG5000	phosphorelay sensor kinase activity
E5180_RS04415	COG2204	response regulator
E5180_RS04420	COG3852	Histidine kinase
E5180_RS04425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5180_RS04430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E5180_RS04430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5180_RS04435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5180_RS04445	COG0004	ammonium transporteR
E5180_RS04450	COG2867	negative regulation of translational initiation
E5180_RS04455	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E5180_RS04460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5180_RS04475	COG5598	trimethylamine methyltransferase
E5180_RS04500	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E5180_RS04505	COG0596	Alpha beta hydrolase
E5180_RS04510	COG2326	polyphosphate kinase activity
E5180_RS04515	COG1309	transcriptional regulator
E5180_RS04520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5180_RS04525	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5180_RS04530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5180_RS04535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5180_RS04550	COG1024	Enoyl-CoA hydratase
E5180_RS04555	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
E5180_RS04560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5180_RS04565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5180_RS04575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5180_RS04580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5180_RS04595	COG0482	sulfurtransferase activity
E5180_RS04600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5180_RS04610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5180_RS04615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5180_RS04625	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5180_RS04630	COG0750	zinc metalloprotease
E5180_RS04635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E5180_RS04645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5180_RS04650	COG0233	cytoplasmic translational termination
E5180_RS04655	COG0528	UMP kinase activity
E5180_RS04660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5180_RS04675	COG0741	lytic transglycosylase activity
E5180_RS04680	COG0629	single-stranded DNA binding
E5180_RS04685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E5180_RS04690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5180_RS04700	COG4974	Belongs to the 'phage' integrase family
E5180_RS04710	COG4536	flavin adenine dinucleotide binding
E5180_RS04735	COG1238	metal cluster binding
E5180_RS04750	COG0010	Belongs to the arginase family
E5180_RS04760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5180_RS04770	COG0542	response to heat
E5180_RS04790	COG1764	response to oxidative stress
E5180_RS04820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5180_RS04835	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E5180_RS04850	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E5180_RS04865	COG0028	Belongs to the TPP enzyme family
E5180_RS04870	COG0440	acetolactate synthase activity
E5180_RS04885	COG0154	amidase activity
E5180_RS04890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E5180_RS04895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E5180_RS04905	COG0436	Aminotransferase
E5180_RS04930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5180_RS04940	COG0156	8-amino-7-oxononanoate synthase activity
E5180_RS04945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5180_RS04960	COG1320	monovalent cation:proton antiporter activity
E5180_RS04965	COG2212	antiporter activity
E5180_RS04970	COG1863	multisubunit Na H antiporter MnhE subunit
E5180_RS04975	COG0651	ATP synthesis coupled electron transport
E5180_RS04980	COG1006	Multisubunit Na H antiporter MnhC subunit
E5180_RS04985	COG2111	Na H antiporter
E5180_RS04985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5180_RS04990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E5180_RS04995	COG0248	Ppx GppA phosphatase
E5180_RS05005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5180_RS05015	COG2205	protein histidine kinase activity
E5180_RS05015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5180_RS05025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5180_RS05040	COG0719	Fe-S assembly protein
E5180_RS05045	COG0396	ATPase activity
E5180_RS05060	COG0719	Fe-S assembly protein
E5180_RS05070	COG1959	2 iron, 2 sulfur cluster binding
E5180_RS05075	COG2945	thiolester hydrolase activity
E5180_RS05090	COG0538	isocitrate dehydrogenase activity
E5180_RS05105	COG0668	transmembrane transport
E5180_RS05110	COG1217	gtp-binding protein TYPA
E5180_RS05120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5180_RS05125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5180_RS05140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5180_RS05140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5180_RS05195	COG0398	Pfam SNARE associated Golgi protein
E5180_RS05275	COG0583	DNA-binding transcription factor activity
E5180_RS05285	COG1175	transmembrane transport
E5180_RS05300	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5180_RS05330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5180_RS05335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5180_RS05340	COG0500	methyltransferase
E5180_RS05345	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5180_RS05345	COG1902	pentaerythritol trinitrate reductase activity
E5180_RS05390	COG1162	GTPase activity
E5180_RS05420	COG1732	Glycine betaine
E5180_RS05425	COG1174	glycine betaine transport
E5180_RS05430	COG1125	glycine betaine transport
E5180_RS05435	COG1174	glycine betaine transport
E5180_RS05445	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E5180_RS05455	COG1268	BioY protein
E5180_RS05460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5180_RS05475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5180_RS05495	COG0351	phosphomethylpyrimidine kinase
E5180_RS05510	COG2022	thiamine diphosphate biosynthetic process
E5180_RS05520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5180_RS05525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5180_RS05530	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5180_RS05535	COG1116	anion transmembrane transporter activity
E5180_RS05540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5180_RS05545	COG1024	Enoyl-CoA hydratase
E5180_RS05555	COG0776	regulation of translation
E5180_RS05560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5180_RS05565	COG1902	pentaerythritol trinitrate reductase activity
E5180_RS05570	COG0343	queuine tRNA-ribosyltransferase activity
E5180_RS05575	COG4067	protein conserved in archaea
E5180_RS05575	COG0189	ligase activity
E5180_RS05580	COG2151	metal-sulfur cluster biosynthetic enzyme
E5180_RS05590	COG0316	Belongs to the HesB IscA family
E5180_RS05595	COG0149	triose-phosphate isomerase activity
E5180_RS05600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5180_RS05605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E5180_RS05610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5180_RS05630	COG1522	sequence-specific DNA binding
E5180_RS05635	COG1648	precorrin-2 dehydrogenase activity
E5180_RS05635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5180_RS05645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5180_RS05670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5180_RS05675	COG2885	chlorophyll binding
E5180_RS05700	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5180_RS05715	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5180_RS05735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5180_RS05745	COG2354	Protein conserved in bacteria
E5180_RS05760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5180_RS05800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5180_RS05805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5180_RS05815	COG2814	Major facilitator Superfamily
E5180_RS05820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5180_RS05830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5180_RS05835	COG2833	Protein of unknown function (DUF455)
E5180_RS05840	COG0739	heme binding
E5180_RS05860	COG0126	phosphoglycerate kinase activity
E5180_RS05870	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5180_RS05875	COG0022	dehydrogenase e1 component
E5180_RS05875	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5180_RS05880	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5180_RS05960	COG4695	Portal protein
E5180_RS05975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5180_RS05980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5180_RS05985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5180_RS05995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E5180_RS06000	COG3038	cytochrome b561
E5180_RS06005	COG2353	YceI-like domain
E5180_RS06015	COG0360	Binds together with S18 to 16S ribosomal RNA
E5180_RS06020	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5180_RS06025	COG0359	binds to the 23S rRNA
E5180_RS06035	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5180_RS06040	COG3750	Belongs to the UPF0335 family
E5180_RS06065	COG5002	protein histidine kinase activity
E5180_RS06075	COG0745	RESPONSE REGULATOR receiver
E5180_RS06080	COG1396	sequence-specific DNA binding
E5180_RS06080	COG3800	Transcriptional regulator
E5180_RS06105	COG0410	ABC transporter
E5180_RS06110	COG0511	ligase activity, forming carbon-carbon bonds
E5180_RS06115	COG0439	Biotin carboxylase
E5180_RS06120	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5180_RS06140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5180_RS06145	COG0740	serine-type endopeptidase activity
E5180_RS06170	COG1121	(ABC) transporter
E5180_RS06175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5180_RS06180	COG2205	protein histidine kinase activity
E5180_RS06180	COG0784	Response regulator, receiver
E5180_RS06190	COG1011	Hydrolase
E5180_RS06200	COG3639	organic phosphonate transmembrane transporter activity
E5180_RS06215	COG1349	DNA-binding transcription factor activity
E5180_RS06220	COG2205	protein histidine kinase activity
E5180_RS06220	COG2202	Pas domain
E5180_RS06280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5180_RS06410	COG1686	Belongs to the peptidase S11 family
E5180_RS06415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5180_RS06425	COG0084	hydrolase, TatD family'
E5180_RS06430	COG1234	tRNA 3'-trailer cleavage
E5180_RS06525	COG3932	Exopolysaccharide synthesis, ExoD
E5180_RS06550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5180_RS06560	COG0626	cystathionine gamma-synthase activity
E5180_RS06565	COG2963	transposase activity
E5180_RS06570	COG0671	phosphoesterase, PA-phosphatase related
E5180_RS06585	COG0745	RESPONSE REGULATOR receiver
E5180_RS06590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5180_RS06595	COG0463	Glycosyl transferase, family 2
E5180_RS06615	COG0668	transmembrane transport
E5180_RS06635	COG2205	protein histidine kinase activity
E5180_RS06665	COG0598	Magnesium transport protein CorA
E5180_RS06685	COG0586	Pfam SNARE associated Golgi protein
E5180_RS06690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E5180_RS06690	COG0392	lysyltransferase activity
E5180_RS06720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5180_RS06780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5180_RS06790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5180_RS06795	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5180_RS06800	COG4133	protoheme IX ABC transporter activity
E5180_RS06805	COG3737	Protein of unknown function (DUF498/DUF598)
E5180_RS06810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5180_RS06815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5180_RS06820	COG1862	Preprotein translocase
E5180_RS06825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5180_RS06835	COG1160	GTP binding
E5180_RS06855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5180_RS06860	COG2814	Major facilitator Superfamily
E5180_RS06870	COG5265	(ABC) transporter
E5180_RS06900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5180_RS06900	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5180_RS06915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5180_RS06920	COG4235	cytochrome complex assembly
E5180_RS06925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5180_RS06940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5180_RS06945	COG1454	alcohol dehydrogenase
E5180_RS06955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5180_RS06970	COG0395	ABC-type sugar transport system, permease component
E5180_RS06980	COG3842	ATPase activity
E5180_RS06985	COG3842	ATPase activity
E5180_RS06995	COG1349	DNA-binding transcription factor activity
E5180_RS07000	COG1175	transmembrane transport
E5180_RS07005	COG0395	ABC-type sugar transport system, permease component
E5180_RS07010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5180_RS07015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5180_RS07020	COG1121	(ABC) transporter
E5180_RS07045	COG0330	HflC and HflK could
E5180_RS07050	COG0330	HflC and HflK could
E5180_RS07060	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5180_RS07065	COG1760	l-serine dehydratase
E5180_RS07075	COG1741	Belongs to the pirin family
E5180_RS07095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5180_RS07160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5180_RS07175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5180_RS07180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5180_RS07185	COG0697	spore germination
E5180_RS07190	COG4175	Glycine betaine
E5180_RS07190	COG3448	diguanylate cyclase activity
E5180_RS07210	COG4608	Belongs to the ABC transporter superfamily
E5180_RS07215	COG0444	Belongs to the ABC transporter superfamily
E5180_RS07220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5180_RS07225	COG0601	transmembrane transport
E5180_RS07235	COG0747	negative chemotaxis
E5180_RS07250	COG1215	transferase activity, transferring glycosyl groups
E5180_RS07270	COG0546	phosphoglycolate phosphatase activity
E5180_RS07315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5180_RS07330	COG0504	CTP synthase activity
E5180_RS07335	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5180_RS07365	COG4215	(ABC) transporter
E5180_RS07370	COG0765	amino acid transport
E5180_RS07375	COG0174	glutamine synthetase
E5180_RS07380	COG0519	Catalyzes the synthesis of GMP from XMP
E5180_RS07385	COG0174	glutamine synthetase
E5180_RS07390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5180_RS07395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5180_RS07410	COG3243	poly(R)-hydroxyalkanoic acid synthase
E5180_RS07450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5180_RS07460	COG3220	belongs to the UPF0276 family
E5180_RS07475	COG1393	Belongs to the ArsC family
E5180_RS07480	COG1278	Cold shock
E5180_RS07495	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E5180_RS07550	COG0534	Mate efflux family protein
E5180_RS07555	COG0596	Alpha beta hydrolase
E5180_RS07560	COG0662	Cupin 2, conserved barrel domain protein
E5180_RS07565	COG0187	DNA topoisomerase II activity
E5180_RS07570	COG1715	Restriction endonuclease
E5180_RS07590	COG1136	(ABC) transporter
E5180_RS07605	COG0442	prolyl-tRNA aminoacylation
E5180_RS07615	COG0628	permease
E5180_RS07625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E5180_RS07630	COG0248	Ppx GppA phosphatase
E5180_RS07645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E5180_RS07660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5180_RS07660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5180_RS07675	COG4770	biotin carboxylase activity
E5180_RS07695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5180_RS07700	COG2814	Major facilitator Superfamily
E5180_RS07705	COG3800	Transcriptional regulator
E5180_RS07705	COG1396	sequence-specific DNA binding
E5180_RS07730	COG3119	arylsulfatase activity
E5180_RS07735	COG1309	transcriptional regulator
E5180_RS07755	COG0217	transcriptional regulatory protein
E5180_RS07760	COG0471	metal ion transport
E5180_RS07760	COG3273	potassium ion transport
E5180_RS07765	COG0471	metal ion transport
E5180_RS07765	COG3273	potassium ion transport
E5180_RS07770	COG1692	metallophosphoesterase
E5180_RS07775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5180_RS07780	COG2239	Acts as a magnesium transporter
E5180_RS07785	COG0402	S-adenosylhomocysteine deaminase activity
E5180_RS07800	COG0483	inositol monophosphate 1-phosphatase activity
E5180_RS07805	COG1396	sequence-specific DNA binding
E5180_RS07810	COG0670	Belongs to the BI1 family
E5180_RS07820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5180_RS07830	COG3023	N-Acetylmuramoyl-L-alanine amidase
E5180_RS07840	COG0154	amidase activity
E5180_RS07845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5180_RS07850	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5180_RS07865	COG0590	tRNA wobble adenosine to inosine editing
E5180_RS07870	COG1187	pseudouridine synthase activity
E5180_RS07915	COG1490	D-aminoacyl-tRNA deacylase activity
E5180_RS07955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5180_RS07960	COG4172	Belongs to the ABC transporter superfamily
E5180_RS07975	COG0318	PFAM AMP-dependent synthetase and ligase
E5180_RS07980	COG1652	LysM domain
E5180_RS07985	COG1132	(ABC) transporter
E5180_RS07995	COG0318	PFAM AMP-dependent synthetase and ligase
E5180_RS08010	COG2080	2 iron, 2 sulfur cluster binding
E5180_RS08015	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E5180_RS08020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5180_RS08025	COG3485	protocatechuate 3,4-dioxygenase
E5180_RS08030	COG3485	protocatechuate 3,4-dioxygenase
E5180_RS08035	COG3246	L-lysine catabolic process to acetate
E5180_RS08045	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E5180_RS08050	COG0583	DNA-binding transcription factor activity
E5180_RS08055	COG2951	lytic endotransglycosylase activity
E5180_RS08070	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E5180_RS08075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E5180_RS08100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E5180_RS08150	COG0348	domain, Protein
E5180_RS08155	COG2010	Cytochrome c
E5180_RS08175	COG0589	response to stress
E5180_RS08180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5180_RS08190	COG3483	tryptophan 2,3-dioxygenase activity
E5180_RS08210	COG0252	asparaginase activity
E5180_RS08215	COG1115	amino acid carrier protein
E5180_RS08220	COG3268	Saccharopine dehydrogenase
E5180_RS08235	COG1522	sequence-specific DNA binding
E5180_RS08250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5180_RS08255	COG2011	ABC-type metal ion transport system permease component
E5180_RS08260	COG1464	Belongs to the NlpA lipoprotein family
E5180_RS08265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5180_RS08270	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E5180_RS08275	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E5180_RS08280	COG0625	glutathione transferase activity
E5180_RS08285	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5180_RS08295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5180_RS08305	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E5180_RS08320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5180_RS08320	COG0512	Glutamine amidotransferase of anthranilate synthase
E5180_RS08330	COG0604	alcohol dehydrogenase
E5180_RS08335	COG0583	DNA-binding transcription factor activity
E5180_RS08340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5180_RS08345	COG1012	belongs to the aldehyde dehydrogenase family
E5180_RS08355	COG5002	protein histidine kinase activity
E5180_RS08370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5180_RS08380	COG1012	belongs to the aldehyde dehydrogenase family
E5180_RS08390	COG0251	oxidation-reduction process
E5180_RS08395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5180_RS08445	COG0642	Histidine kinase
E5180_RS08470	COG2132	Multicopper oxidase
E5180_RS08530	COG1278	Cold shock
E5180_RS08600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5180_RS08605	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E5180_RS08610	COG0124	histidyl-tRNA synthetase
E5180_RS08615	COG2900	Belongs to the SlyX family
E5180_RS08630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5180_RS08640	COG3845	ABC transporter
E5180_RS08645	COG4603	Belongs to the binding-protein-dependent transport system permease family
E5180_RS08650	COG1079	Belongs to the binding-protein-dependent transport system permease family
E5180_RS08670	COG0625	glutathione transferase activity
E5180_RS08700	COG0277	FAD linked oxidase domain protein
E5180_RS08720	COG1063	alcohol dehydrogenase
E5180_RS08745	COG1802	Transcriptional regulator
E5180_RS08750	COG0747	negative chemotaxis
E5180_RS08755	COG0601	transmembrane transport
E5180_RS08760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5180_RS08765	COG0444	Belongs to the ABC transporter superfamily
E5180_RS08770	COG4608	Belongs to the ABC transporter superfamily
E5180_RS08775	COG0405	Gamma-glutamyltransferase
E5180_RS08785	COG1116	anion transmembrane transporter activity
E5180_RS08790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5180_RS08800	COG0402	S-adenosylhomocysteine deaminase activity
E5180_RS08815	COG3135	benzoate transporter
E5180_RS08820	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E5180_RS08830	COG4191	Histidine kinase
E5180_RS08830	COG0784	Response regulator, receiver
E5180_RS08835	COG2205	protein histidine kinase activity
E5180_RS08835	COG0784	Response regulator, receiver
E5180_RS08835	COG5002	protein histidine kinase activity
E5180_RS08845	COG1522	sequence-specific DNA binding
E5180_RS08850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5180_RS08855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5180_RS08865	COG0583	DNA-binding transcription factor activity
E5180_RS08875	COG2080	2 iron, 2 sulfur cluster binding
E5180_RS08880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E5180_RS08885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5180_RS08900	COG1522	sequence-specific DNA binding
E5180_RS08905	COG0006	proline dipeptidase activity
E5180_RS08910	COG3608	succinylglutamate desuccinylase aspartoacylase
E5180_RS08915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E5180_RS08925	COG1757	Na H antiporter
E5180_RS08930	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E5180_RS08935	COG2943	transferase activity, transferring hexosyl groups
E5180_RS08945	COG0668	transmembrane transport
E5180_RS08950	COG0028	Belongs to the TPP enzyme family
E5180_RS08955	COG0318	PFAM AMP-dependent synthetase and ligase
E5180_RS08990	COG0737	Belongs to the 5'-nucleotidase family
E5180_RS08995	COG3258	Cytochrome c
E5180_RS09020	COG0785	Cytochrome C biogenesis protein
E5180_RS09045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5180_RS09065	COG0318	PFAM AMP-dependent synthetase and ligase
E5180_RS09070	COG1024	Enoyl-CoA hydratase
E5180_RS09080	COG1960	acyl-CoA dehydrogenase activity
E5180_RS09085	COG1960	acyl-CoA dehydrogenase activity
E5180_RS09090	COG1024	Enoyl-CoA hydratase
E5180_RS09090	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5180_RS09125	COG0747	negative chemotaxis
E5180_RS09130	COG0601	transmembrane transport
E5180_RS09135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5180_RS09140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5180_RS09145	COG0668	transmembrane transport
E5180_RS09160	COG0438	transferase activity, transferring glycosyl groups
E5180_RS09165	COG0588	phosphoglycerate mutase activity
E5180_RS09180	COG0481	GTPase activity
E5180_RS09200	COG5328	Belongs to the UPF0262 family
E5180_RS09205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5180_RS09215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5180_RS09235	COG0778	Nitroreductase
E5180_RS09245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5180_RS09260	COG4774	siderophore transport
E5180_RS09265	COG3128	pkhd-type hydroxylase
E5180_RS09275	COG0848	biopolymer transport protein
E5180_RS09290	COG2323	membrane
E5180_RS09315	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5180_RS09340	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E5180_RS09420	COG1335	isochorismatase
E5180_RS09450	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5180_RS09460	COG0424	maF-like protein
E5180_RS09465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5180_RS09470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5180_RS09495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5180_RS09500	COG1183	phosphatidylcholine synthase activity
E5180_RS09510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5180_RS09515	COG3768	UPF0283 membrane protein
E5180_RS09525	COG3106	COG3106 Predicted ATPase
E5180_RS09530	COG0101	tRNA pseudouridine synthase activity
E5180_RS09535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E5180_RS09540	COG1051	belongs to the nudix hydrolase family
E5180_RS09545	COG0306	phosphate transporter
E5180_RS09555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5180_RS09560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5180_RS09575	COG0612	Peptidase, M16
E5180_RS09585	COG3346	SURF1 family
E5180_RS09595	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E5180_RS09605	COG0109	protoheme IX farnesyltransferase activity
E5180_RS09615	COG0312	modulator of DNA gyrase
E5180_RS09620	COG0758	DNA mediated transformation
E5180_RS09625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5180_RS09625	COG1754	DNA topoisomerase type I activity
E5180_RS09640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5180_RS09645	COG0741	lytic transglycosylase activity
E5180_RS09660	COG4964	Belongs to the GSP D family
E5180_RS09710	COG1201	RNA secondary structure unwinding
E5180_RS09725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5180_RS09730	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E5180_RS09740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5180_RS09745	COG0037	tRNA processing
E5180_RS09755	COG2885	chlorophyll binding
E5180_RS09760	COG0823	Involved in the tonB-independent uptake of proteins
E5180_RS09780	COG0824	Thioesterase
E5180_RS09790	COG2255	four-way junction helicase activity
E5180_RS09795	COG0632	four-way junction helicase activity
E5180_RS09830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5180_RS09845	COG1703	isobutyryl-CoA mutase activity
E5180_RS09850	COG1643	Atp-dependent helicase
E5180_RS09860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5180_RS09880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5180_RS09885	COG1309	transcriptional regulator
E5180_RS09895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5180_RS09900	COG4529	Protein conserved in bacteria
E5180_RS09905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E5180_RS09910	COG0583	DNA-binding transcription factor activity
E5180_RS09925	COG1902	pentaerythritol trinitrate reductase activity
E5180_RS09925	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5180_RS10025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5180_RS10035	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5180_RS10045	COG0713	ATP synthesis coupled electron transport
E5180_RS10055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5180_RS10060	COG1007	ATP synthesis coupled electron transport
E5180_RS10075	COG2132	Multicopper oxidase
E5180_RS10090	COG0583	DNA-binding transcription factor activity
E5180_RS10110	COG0012	GTP binding
E5180_RS10120	COG0159	tryptophan synthase activity
E5180_RS10130	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5180_RS10135	COG0193	aminoacyl-tRNA hydrolase activity
E5180_RS10160	COG0133	tryptophan synthase activity
E5180_RS10170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5180_RS10180	COG1272	protein, Hemolysin III
E5180_RS10210	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E5180_RS10225	COG1744	ABC transporter substrate-binding protein PnrA-like
E5180_RS10230	COG3845	ABC transporter
E5180_RS10235	COG4603	Belongs to the binding-protein-dependent transport system permease family
E5180_RS10240	COG1079	Belongs to the binding-protein-dependent transport system permease family
E5180_RS10245	COG0730	response to heat
E5180_RS10255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5180_RS10260	COG0604	alcohol dehydrogenase
E5180_RS10270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5180_RS10270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5180_RS10280	COG0813	purine-nucleoside phosphorylase activity
E5180_RS10325	COG0039	L-malate dehydrogenase activity
E5180_RS10335	COG2301	Belongs to the HpcH HpaI aldolase family
E5180_RS10350	COG2030	dehydratase
E5180_RS10355	COG0045	succinate-CoA ligase (ADP-forming) activity
E5180_RS10380	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5180_RS10410	COG2884	Cell division ATP-binding protein ftsE
E5180_RS10425	COG0019	diaminopimelate decarboxylase activity
E5180_RS10445	COG0165	Argininosuccinate lyase
E5180_RS10450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5180_RS10470	COG0800	Aldolase
E5180_RS10475	COG0129	dihydroxy-acid dehydratase activity
E5180_RS10480	COG2971	BadF BadG BcrA BcrD
E5180_RS10485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5180_RS10515	COG1921	L-seryl-tRNASec selenium transferase activity
E5180_RS10535	COG0556	nucleotide-excision repair
E5180_RS10575	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E5180_RS10585	COG2027	D-alanyl-D-alanine carboxypeptidase
E5180_RS10590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5180_RS10595	COG1115	amino acid carrier protein
E5180_RS10605	COG0488	(ABC) transporter
E5180_RS10615	COG1278	Cold shock
E5180_RS10620	COG1376	ErfK ybiS ycfS ynhG family protein
E5180_RS10625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5180_RS10630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5180_RS10635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5180_RS10655	COG1309	transcriptional regulator
E5180_RS10665	COG0493	'glutamate synthase
E5180_RS10670	COG1278	Cold shock
E5180_RS10680	COG4181	ATPase activity
E5180_RS10685	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E5180_RS10690	COG0483	inositol monophosphate 1-phosphatase activity
E5180_RS10695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5180_RS10695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5180_RS10700	COG0509	glycine decarboxylation via glycine cleavage system
E5180_RS10705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5180_RS10720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5180_RS10735	COG3046	protein related to deoxyribodipyrimidine photolyase
E5180_RS10745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5180_RS10775	COG0768	penicillin binding
E5180_RS10780	COG0772	Belongs to the SEDS family
E5180_RS10785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5180_RS10790	COG0339	signal peptide processing
E5180_RS10795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5180_RS10800	COG3454	Phosphonate metabolism
E5180_RS10810	COG4778	phosphonate C-P lyase system protein PhnL
E5180_RS10815	COG4107	phosphonate C-P lyase system protein PhnK
E5180_RS10820	COG3627	carbon phosphorus lyase activity
E5180_RS10825	COG3626	phosphonate metabolism
E5180_RS10830	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
E5180_RS10835	COG3624	Phosphonate C-P lyase system protein PhnG
E5180_RS10840	COG2188	Transcriptional regulator
E5180_RS10850	COG3639	organic phosphonate transmembrane transporter activity
E5180_RS10860	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E5180_RS10875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5180_RS10890	COG0606	chelatase, subunit chli
E5180_RS10900	COG0189	ligase activity
E5180_RS10910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5180_RS10920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5180_RS10935	COG0180	Tryptophanyl-tRNA synthetase
E5180_RS10945	COG0778	Nitroreductase
E5180_RS10960	COG0346	lactoylglutathione lyase activity
E5180_RS10965	COG0745	RESPONSE REGULATOR receiver
E5180_RS10985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5180_RS10990	COG0019	diaminopimelate decarboxylase activity
E5180_RS11010	COG2197	response regulator
E5180_RS11030	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E5180_RS11035	COG1122	ATPase activity
E5180_RS11045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5180_RS11055	COG1522	sequence-specific DNA binding
E5180_RS11060	COG0686	Belongs to the AlaDH PNT family
E5180_RS11065	COG1970	mechanosensitive ion channel activity
E5180_RS11075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5180_RS11075	COG0072	phenylalanine-tRNA ligase activity
E5180_RS11090	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5180_RS11100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5180_RS11105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E5180_RS11115	COG0469	pyruvate kinase activity
E5180_RS11130	COG4948	Mandelate Racemase Muconate Lactonizing
E5180_RS11150	COG0825	malonyl-CoA metabolic process
E5180_RS11240	COG1525	nuclease
E5180_RS11255	COG1309	transcriptional regulator
E5180_RS11270	COG1917	Cupin 2, conserved barrel domain protein
E5180_RS11270	COG2207	Transcriptional regulator
E5180_RS11290	COG0829	nickel cation binding
E5180_RS11295	COG0831	urea catabolic process
E5180_RS11305	COG0832	Belongs to the urease beta subunit family
E5180_RS11310	COG0804	urea catabolic process
E5180_RS11315	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E5180_RS11320	COG0830	nickel cation binding
E5180_RS11325	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E5180_RS11340	COG0513	Belongs to the DEAD box helicase family
E5180_RS11345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E5180_RS11355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5180_RS11360	COG0741	lytic transglycosylase activity
E5180_RS11365	COG0697	spore germination
E5180_RS11370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5180_RS11370	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E5180_RS11385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5180_RS11390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5180_RS11395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5180_RS11410	COG1051	belongs to the nudix hydrolase family
E5180_RS11415	COG1902	pentaerythritol trinitrate reductase activity
E5180_RS11415	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5180_RS11425	COG0583	DNA-binding transcription factor activity
E5180_RS11445	COG1546	Belongs to the CinA family
E5180_RS11445	COG1058	Belongs to the CinA family
E5180_RS11450	COG1489	DNA binding
E5180_RS11455	COG0024	Methionine aminopeptidase
E5180_RS11460	COG1183	phosphatidylcholine synthase activity
E5180_RS11465	COG0688	phosphatidylethanolamine metabolic process
E5180_RS11470	COG0742	ribosomal rna small subunit methyltransferase
E5180_RS11480	COG0678	peroxiredoxin activity
E5180_RS11485	COG2154	pterin-4-alpha-carbinolamine dehydratase
E5180_RS11495	COG0584	glycerophosphoryl diester phosphodiesterase
E5180_RS11505	COG2853	Lipoprotein
E5180_RS11515	COG0347	Belongs to the P(II) protein family
E5180_RS11520	COG0004	ammonium transporteR
E5180_RS11530	COG2897	thiosulfate sulfurtransferase activity
E5180_RS11535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5180_RS11585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5180_RS11600	COG0247	lactate metabolic process
E5180_RS11610	COG0277	FAD linked oxidase domain protein
E5180_RS11615	COG0277	FAD linked oxidase domain protein
E5180_RS11630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5180_RS11635	COG0799	negative regulation of ribosome biogenesis
E5180_RS11640	COG3264	Mechanosensitive ion channel
E5180_RS11640	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E5180_RS11645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5180_RS11650	COG0066	3-isopropylmalate dehydratase activity
E5180_RS11665	COG0473	3-isopropylmalate dehydrogenase activity
E5180_RS11675	COG1609	Transcriptional regulator
E5180_RS11680	COG3214	Protein conserved in bacteria
E5180_RS11685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5180_RS11690	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E5180_RS11705	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E5180_RS11715	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E5180_RS11725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5180_RS11730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5180_RS11755	COG0625	glutathione transferase activity
E5180_RS11760	COG2808	Putative FMN-binding domain
E5180_RS11770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5180_RS11775	COG0142	geranyltranstransferase activity
E5180_RS11780	COG1722	exodeoxyribonuclease VII activity
E5180_RS11785	COG0745	RESPONSE REGULATOR receiver
E5180_RS11790	COG1846	Transcriptional regulator
E5180_RS11795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5180_RS11810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5180_RS11815	COG4143	(ABC) transporter
E5180_RS11820	COG1178	ABC-type Fe3 transport system permease component
E5180_RS11825	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E5180_RS11840	COG0438	transferase activity, transferring glycosyl groups
E5180_RS11845	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E5180_RS11850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5180_RS11860	COG0697	spore germination
E5180_RS11870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5180_RS11880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5180_RS11890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5180_RS11910	COG1968	undecaprenyl-diphosphatase activity
E5180_RS11965	COG4717	serine-type aminopeptidase activity
E5180_RS11975	COG0709	Synthesizes selenophosphate from selenide and ATP
E5180_RS12095	COG0463	Glycosyl transferase, family 2
E5180_RS12110	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5180_RS12115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5180_RS12130	COG0653	protein targeting
E5180_RS12135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5180_RS12140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5180_RS12145	COG0494	nUDIX hydrolase
E5180_RS12150	COG1597	lipid kinase activity
E5180_RS12150	COG1803	Methylglyoxal synthase
E5180_RS12160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5180_RS12175	COG0779	Required for maturation of 30S ribosomal subunits
E5180_RS12190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5180_RS12200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5180_RS12210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5180_RS12240	COG3034	peptidoglycan biosynthetic process
E5180_RS12255	COG1132	(ABC) transporter
E5180_RS12260	COG1132	(ABC) transporter
E5180_RS12265	COG0617	tRNA 3'-terminal CCA addition
E5180_RS12270	COG0494	nUDIX hydrolase
E5180_RS12295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5180_RS12300	COG0137	argininosuccinate synthase activity
E5180_RS12320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5180_RS12330	COG0280	phosphate acetyltransferase
E5180_RS12330	COG0281	malic enzyme
E5180_RS12335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5180_RS12340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5180_RS12345	COG1420	regulation of RNA biosynthetic process
E5180_RS12350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5180_RS12355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5180_RS12360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5180_RS12375	COG0357	Ribosomal RNA small subunit methyltransferase G
E5180_RS12380	COG0445	tRNA wobble uridine modification
E5180_RS12385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5180_RS12390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E5180_RS12395	COG1981	membrane
E5180_RS12400	COG0424	maF-like protein
E5180_RS12405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5180_RS12410	COG0237	dephospho-CoA kinase activity
E5180_RS12415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5180_RS12420	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E5180_RS12450	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E5180_RS12455	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E5180_RS12470	COG1074	ATP-dependent DNA helicase activity
E5180_RS12480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5180_RS12485	COG3178	'Phosphotransferase
E5180_RS12490	COG0802	atpase or kinase
E5180_RS12505	COG1999	signal sequence binding
E5180_RS12510	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E5180_RS12520	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E5180_RS12530	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5180_RS12550	COG2350	Protein conserved in bacteria
E5180_RS12555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5180_RS12560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5180_RS12590	COG3474	cytochrome
E5180_RS12595	COG3191	aminopeptidase activity
E5180_RS12605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5180_RS12625	COG1216	Glycosyl transferase, family 2
E5180_RS12655	COG0747	negative chemotaxis
E5180_RS12665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5180_RS12675	COG2116	formate transmembrane transporter activity
E5180_RS12680	COG1295	ribonuclease BN
E5180_RS12705	COG0784	Response regulator, receiver
E5180_RS12725	COG1396	sequence-specific DNA binding
E5180_RS12730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5180_RS12735	COG0069	glutamate synthase activity
E5180_RS12780	COG2995	paraquat-inducible protein a
E5180_RS12785	COG3008	intermembrane lipid transfer
E5180_RS12785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5180_RS12795	COG0489	protein tyrosine kinase activity
E5180_RS12795	COG3206	protein involved in exopolysaccharide biosynthesis
E5180_RS12810	COG2003	Belongs to the UPF0758 family
E5180_RS12815	COG0484	heat shock protein binding
E5180_RS12820	COG0443	Heat shock 70 kDa protein
E5180_RS12840	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E5180_RS12850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5180_RS12875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5180_RS12880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E5180_RS12885	COG1137	ATPase activity
E5180_RS12900	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5180_RS12900	COG0517	IMP dehydrogenase activity
E5180_RS12915	COG1012	belongs to the aldehyde dehydrogenase family
E5180_RS12915	COG2030	dehydratase
E5180_RS12920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5180_RS12925	COG2151	metal-sulfur cluster biosynthetic enzyme
E5180_RS12930	COG3396	Phenylacetate-CoA oxygenase
E5180_RS12935	COG3460	Phenylacetate-CoA oxygenase
E5180_RS12940	COG3396	Phenylacetate-CoA oxygenase
E5180_RS12945	COG0183	Belongs to the thiolase family
E5180_RS12965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5180_RS12980	COG2171	N-acyltransferase activity
E5180_RS12995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5180_RS13010	COG0557	exoribonuclease II activity
E5180_RS13015	COG2951	lytic endotransglycosylase activity
E5180_RS13035	COG3842	ATPase activity
E5180_RS13045	COG1802	Transcriptional regulator
E5180_RS13050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E5180_RS13055	COG3842	ATPase activity
E5180_RS13060	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5180_RS13065	COG1177	transmembrane transport
E5180_RS13070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5180_RS13075	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E5180_RS13080	COG1054	Belongs to the UPF0176 family
E5180_RS13085	COG1335	isochorismatase
E5180_RS13090	COG2095	MarC family integral membrane protein
E5180_RS13095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5180_RS13110	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E5180_RS13120	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
E5180_RS13140	COG0514	ATP-dependent DNA helicase (RecQ)
E5180_RS13145	COG3022	response to hydroperoxide
E5180_RS13150	COG2205	protein histidine kinase activity
E5180_RS13150	COG0784	Response regulator, receiver
E5180_RS13150	COG5002	protein histidine kinase activity
E5180_RS13170	COG0714	Associated with various cellular activities
E5180_RS13180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5180_RS13180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5180_RS13195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5180_RS13205	COG0793	Belongs to the peptidase S41A family
E5180_RS13225	COG0129	dihydroxy-acid dehydratase activity
E5180_RS13230	COG2274	protein secretion by the type I secretion system
E5180_RS13240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5180_RS13245	COG0285	dihydrofolate synthase activity
E5180_RS13255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5180_RS13265	COG0596	Alpha beta hydrolase
E5180_RS13270	COG2423	ornithine cyclodeaminase activity
E5180_RS13280	COG1671	Belongs to the UPF0178 family
E5180_RS13285	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E5180_RS13300	COG2050	protein possibly involved in aromatic compounds catabolism
E5180_RS13310	COG0791	NLP P60 protein
E5180_RS13315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5180_RS13325	COG0288	reversible hydration of carbon dioxide
E5180_RS13335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5180_RS13365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5180_RS13380	COG1194	a g-specific adenine glycosylase
E5180_RS13400	COG1663	tetraacyldisaccharide 4'-kinase activity
E5180_RS13405	COG1519	Transferase
E5180_RS13420	COG0312	modulator of DNA gyrase
E5180_RS13445	COG0625	glutathione transferase activity
E5180_RS13460	COG0495	leucyl-tRNA aminoacylation
E5180_RS13475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E5180_RS13495	COG0708	Exodeoxyribonuclease III
E5180_RS13510	COG2835	tetraacyldisaccharide 4'-kinase activity
E5180_RS13515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5180_RS13525	COG0436	Aminotransferase
E5180_RS13530	COG1674	ftsk spoiiie
E5180_RS13550	COG0405	Gamma-glutamyltransferase
E5180_RS13560	COG1366	Belongs to the anti-sigma-factor antagonist family
E5180_RS13565	COG0183	Belongs to the thiolase family
E5180_RS13570	COG1956	GAF domain-containing protein
E5180_RS13590	COG0564	pseudouridine synthase activity
E5180_RS13600	COG0450	alkyl hydroperoxide reductase
E5180_RS13625	COG0437	4 iron, 4 sulfur cluster binding
E5180_RS13630	COG0243	molybdopterin cofactor binding
E5180_RS13630	COG3383	formate dehydrogenase (NAD+) activity
E5180_RS13665	COG0489	protein tyrosine kinase activity
E5180_RS13695	COG1185	polyribonucleotide nucleotidyltransferase activity
E5180_RS13705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5180_RS13720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5180_RS13725	COG3698	Phosphodiester glycosidase
E5180_RS13730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5180_RS13735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5180_RS13750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5180_RS13750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5180_RS13760	COG0138	bifunctional purine biosynthesis protein purh
E5180_RS13775	COG0612	Peptidase, M16
E5180_RS13780	COG0612	Peptidase, M16
E5180_RS13785	COG1012	belongs to the aldehyde dehydrogenase family
E5180_RS13795	COG2351	hydroxyisourate hydrolase activity
E5180_RS13805	COG3257	ureidoglycine aminohydrolase activity
E5180_RS13810	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E5180_RS13825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5180_RS13845	COG2814	Major facilitator Superfamily
E5180_RS13865	COG0625	glutathione transferase activity
E5180_RS13875	COG3383	formate dehydrogenase (NAD+) activity
E5180_RS13905	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5180_RS13925	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E5180_RS13930	COG1178	ABC-type Fe3 transport system permease component
E5180_RS13935	COG1840	ABC-type Fe3 transport system, periplasmic component
E5180_RS13940	COG0625	glutathione transferase activity
E5180_RS13945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5180_RS13960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5180_RS13965	COG0284	orotidine-5'-phosphate decarboxylase activity
E5180_RS13980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E5180_RS13985	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E5180_RS14035	COG2194	sulfuric ester hydrolase activity
E5180_RS14050	COG0642	Histidine kinase
E5180_RS14095	COG2205	protein histidine kinase activity
E5180_RS14100	COG0745	RESPONSE REGULATOR receiver
E5180_RS14120	COG0583	DNA-binding transcription factor activity
E5180_RS14125	COG2814	Major facilitator Superfamily
E5180_RS14145	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5180_RS14155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5180_RS14160	COG0268	Binds directly to 16S ribosomal RNA
E5180_RS14165	COG1024	Enoyl-CoA hydratase
E5180_RS14170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5180_RS14175	COG2226	methyltransferase
E5180_RS14180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5180_RS14185	COG1396	sequence-specific DNA binding
E5180_RS14190	COG0156	8-amino-7-oxononanoate synthase activity
E5180_RS14195	COG1063	alcohol dehydrogenase
E5180_RS14200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5180_RS14205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E5180_RS14250	COG1648	precorrin-2 dehydrogenase activity
E5180_RS14250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5180_RS14255	COG1797	cobyrinic acid a,c-diamide synthase activity
E5180_RS14260	COG2875	Belongs to the precorrin methyltransferase family
E5180_RS14275	COG2099	Precorrin-6x reductase
E5180_RS14315	COG1492	cobalamin metabolic process
E5180_RS14320	COG1268	BioY protein
E5180_RS14325	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E5180_RS14325	COG0662	Cupin 2, conserved barrel domain protein
E5180_RS14330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5180_RS14355	COG0406	alpha-ribazole phosphatase activity
E5180_RS14360	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5180_RS14365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5180_RS14385	COG2321	neutral zinc metallopeptidase
E5180_RS14395	COG2816	NAD+ diphosphatase activity
E5180_RS14405	COG0077	Prephenate dehydratase
E5180_RS14415	COG4166	transmembrane transport
E5180_RS14420	COG4174	ABC transporter (Permease)
E5180_RS14425	COG4239	(ABC) transporter, permease
E5180_RS14430	COG4172	Belongs to the ABC transporter superfamily
E5180_RS14435	COG1686	Belongs to the peptidase S11 family
E5180_RS14445	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5180_RS14455	COG1028	Short-chain dehydrogenase reductase Sdr
E5180_RS14460	COG0408	coproporphyrinogen oxidase activity
E5180_RS14465	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E5180_RS14470	COG0181	hydroxymethylbilane synthase activity
E5180_RS14475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5180_RS14505	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5180_RS14515	COG0489	protein tyrosine kinase activity
E5180_RS14515	COG2151	metal-sulfur cluster biosynthetic enzyme
E5180_RS14525	COG0254	rRNA binding
E5180_RS14530	COG0335	large ribosomal subunit rRNA binding
E5180_RS14535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5180_RS14540	COG0336	Belongs to the RNA methyltransferase TrmD family
E5180_RS14545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5180_RS14550	COG0228	four-way junction DNA binding
E5180_RS14560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5180_RS14565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5180_RS14590	COG0356	it plays a direct role in the translocation of protons across the membrane
E5180_RS14595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5180_RS14600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5180_RS14605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5180_RS14625	COG0435	Glutathione S-transferase
E5180_RS14635	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5180_RS14640	COG0242	peptide deformylase activity
E5180_RS14645	COG0242	peptide deformylase activity
E5180_RS14650	COG0242	peptide deformylase activity
E5180_RS14655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5180_RS14665	COG2860	membrane
E5180_RS14670	COG0328	RNA-DNA hybrid ribonuclease activity
E5180_RS14680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5180_RS14695	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5180_RS14700	COG1758	RNA polymerase activity
E5180_RS14715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5180_RS14720	COG0736	holo-[acyl-carrier-protein] synthase activity
E5180_RS14725	COG0681	Belongs to the peptidase S26 family
E5180_RS14730	COG0571	ribonuclease III activity
E5180_RS14735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5180_RS14745	COG1381	Involved in DNA repair and RecF pathway recombination
E5180_RS14765	COG1396	sequence-specific DNA binding
E5180_RS14780	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E5180_RS14785	COG0745	RESPONSE REGULATOR receiver
E5180_RS14790	COG2205	protein histidine kinase activity
E5180_RS14800	COG1660	Displays ATPase and GTPase activities
E5180_RS14810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5180_RS14820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5180_RS14830	COG0300	oxidoreductase activity
E5180_RS14840	COG2096	Adenosyltransferase
E5180_RS14860	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5180_RS14875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5180_RS14885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5180_RS14890	COG0250	Participates in transcription elongation, termination and antitermination
E5180_RS14895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5180_RS14900	COG0081	regulation of translation
E5180_RS14905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5180_RS14910	COG0222	ribosome binding
E5180_RS14915	COG0085	RNA polymerase activity
E5180_RS14920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5180_RS14925	COG0697	spore germination
E5180_RS14935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5180_RS14940	COG0049	tRNA binding
E5180_RS14945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5180_RS15000	COG1475	DNA binding
E5180_RS15030	COG1192	Involved in chromosome partitioning
E5180_RS15035	COG4974	Belongs to the 'phage' integrase family
E5180_RS15075	COG0084	hydrolase, TatD family'
E5180_RS15115	COG1733	regulation of RNA biosynthetic process
E5180_RS15120	COG3384	dioxygenase
E5180_RS15125	COG0702	epimerase
E5180_RS15145	COG1960	acyl-CoA dehydrogenase activity
E5180_RS15160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5180_RS15175	COG1703	isobutyryl-CoA mutase activity
E5180_RS15180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5180_RS15185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E5180_RS15195	COG1309	transcriptional regulator
E5180_RS15200	COG1028	Short-chain dehydrogenase reductase Sdr
E5180_RS15205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5180_RS15210	COG0702	epimerase
E5180_RS15215	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5180_RS15215	COG1902	pentaerythritol trinitrate reductase activity
E5180_RS15220	COG1960	acyl-CoA dehydrogenase activity
E5180_RS15235	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E5180_RS15240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5180_RS15255	COG1028	Short-chain dehydrogenase reductase Sdr
E5180_RS15265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5180_RS15270	COG1960	acyl-CoA dehydrogenase activity
E5180_RS15275	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E5180_RS15280	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E5180_RS15290	COG1960	acyl-CoA dehydrogenase activity
E5180_RS15295	COG1960	acyl-CoA dehydrogenase activity
E5180_RS15300	COG2030	dehydratase
E5180_RS15315	COG2030	dehydratase
E5180_RS15320	COG0183	Belongs to the thiolase family
E5180_RS15330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5180_RS15345	COG1024	Enoyl-CoA hydratase
E5180_RS15350	COG1024	Enoyl-CoA hydratase
E5180_RS15370	COG0559	Belongs to the binding-protein-dependent transport system permease family
E5180_RS15385	COG1028	Short-chain dehydrogenase reductase Sdr
E5180_RS15395	COG1960	acyl-CoA dehydrogenase activity
E5180_RS15400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5180_RS15405	COG1028	Short-chain dehydrogenase reductase Sdr
E5180_RS15415	COG0318	PFAM AMP-dependent synthetase and ligase
E5180_RS15420	COG1960	acyl-CoA dehydrogenase activity
E5180_RS15425	COG1960	acyl-CoA dehydrogenase activity
E5180_RS15430	COG1028	Short-chain dehydrogenase reductase Sdr
E5180_RS15435	COG1024	Enoyl-CoA hydratase
E5180_RS15470	COG1196	nuclear chromosome segregation
E5180_RS15470	COG0741	lytic transglycosylase activity
E5180_RS15470	COG0739	heme binding
E5180_RS15490	COG0741	lytic transglycosylase activity
E5180_RS15490	COG0739	heme binding
E5180_RS15490	COG1196	nuclear chromosome segregation
E5180_RS15510	COG2948	multi-organism process
E5180_RS15540	COG1132	(ABC) transporter
E5180_RS15575	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E5180_RS15615	COG0517	IMP dehydrogenase activity
E5180_RS15620	COG4974	Belongs to the 'phage' integrase family