locus-tag	class	description
IV89_RS00005	COG1192	Involved in chromosome partitioning
IV89_RS00010	COG1475	DNA binding
IV89_RS00015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IV89_RS00050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IV89_RS00055	COG2010	Cytochrome c
IV89_RS00055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IV89_RS00060	COG0531	amino acid
IV89_RS00065	COG0586	Pfam SNARE associated Golgi protein
IV89_RS00095	COG1285	pathogenesis
IV89_RS00105	COG2032	superoxide dismutase activity
IV89_RS00115	COG0783	Belongs to the Dps family
IV89_RS00125	COG4774	siderophore transport
IV89_RS00130	COG2814	Major facilitator Superfamily
IV89_RS00155	COG1024	Enoyl-CoA hydratase
IV89_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IV89_RS00175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IV89_RS00205	COG2855	membrane
IV89_RS00215	COG2205	protein histidine kinase activity
IV89_RS00250	COG1309	transcriptional regulator
IV89_RS00275	COG2205	protein histidine kinase activity
IV89_RS00285	COG3654	unkown
IV89_RS00320	COG3181	Tripartite tricarboxylate transporter family receptor
IV89_RS00325	COG0583	DNA-binding transcription factor activity
IV89_RS00355	COG2132	Multicopper oxidase
IV89_RS00370	COG1629	transport
IV89_RS00375	COG3720	iron ion transport
IV89_RS00380	COG4558	Periplasmic binding protein
IV89_RS00385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IV89_RS00390	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IV89_RS00395	COG2202	Pas domain
IV89_RS00395	COG3920	Histidine kinase
IV89_RS00410	COG1573	uracil-dna glycosylase
IV89_RS00435	COG4585	Histidine kinase
IV89_RS00450	COG1309	transcriptional regulator
IV89_RS00480	COG1609	Transcriptional regulator
IV89_RS00500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IV89_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS00510	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IV89_RS00540	COG2188	Transcriptional regulator
IV89_RS00545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IV89_RS00550	COG0066	3-isopropylmalate dehydratase activity
IV89_RS00555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IV89_RS00685	COG1741	Belongs to the pirin family
IV89_RS00690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IV89_RS00705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IV89_RS00715	COG2267	carboxylic ester hydrolase activity
IV89_RS00720	COG3246	L-lysine catabolic process to acetate
IV89_RS00725	COG3485	protocatechuate 3,4-dioxygenase
IV89_RS00730	COG3485	protocatechuate 3,4-dioxygenase
IV89_RS00735	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IV89_RS00740	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IV89_RS00740	COG1082	Xylose isomerase domain protein TIM barrel
IV89_RS00745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IV89_RS00755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IV89_RS00760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IV89_RS00765	COG1309	transcriptional regulator
IV89_RS00780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IV89_RS00790	COG1414	Transcriptional regulator
IV89_RS00865	COG2423	ornithine cyclodeaminase activity
IV89_RS00880	COG1335	isochorismatase
IV89_RS00885	COG4160	amino acid transport
IV89_RS00890	COG4215	(ABC) transporter
IV89_RS00895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IV89_RS00905	COG0583	DNA-binding transcription factor activity
IV89_RS00915	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS00935	COG1073	alpha beta
IV89_RS00940	COG1309	transcriptional regulator
IV89_RS00945	COG0583	DNA-binding transcription factor activity
IV89_RS00985	COG0625	glutathione transferase activity
IV89_RS00990	COG0583	DNA-binding transcription factor activity
IV89_RS00995	COG0583	DNA-binding transcription factor activity
IV89_RS01040	COG1335	isochorismatase
IV89_RS01045	COG3845	ABC transporter
IV89_RS01055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IV89_RS01075	COG0583	DNA-binding transcription factor activity
IV89_RS01095	COG1704	LemA family
IV89_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS01135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IV89_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS01160	COG0183	Belongs to the thiolase family
IV89_RS01180	COG0183	Belongs to the thiolase family
IV89_RS01185	COG1024	Enoyl-CoA hydratase
IV89_RS01190	COG1024	Enoyl-CoA hydratase
IV89_RS01210	COG0318	PFAM AMP-dependent synthetase and ligase
IV89_RS01225	COG1960	acyl-CoA dehydrogenase activity
IV89_RS01230	COG1024	Enoyl-CoA hydratase
IV89_RS01265	COG0318	PFAM AMP-dependent synthetase and ligase
IV89_RS01295	COG4608	Belongs to the ABC transporter superfamily
IV89_RS01300	COG0444	Belongs to the ABC transporter superfamily
IV89_RS01305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IV89_RS01315	COG0747	negative chemotaxis
IV89_RS01320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IV89_RS01325	COG0251	oxidation-reduction process
IV89_RS01330	COG0583	DNA-binding transcription factor activity
IV89_RS01335	COG2423	ornithine cyclodeaminase activity
IV89_RS01345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IV89_RS01360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IV89_RS01365	COG0587	DNA-directed DNA polymerase activity
IV89_RS01410	COG4717	serine-type aminopeptidase activity
IV89_RS01420	COG0709	Synthesizes selenophosphate from selenide and ATP
IV89_RS01430	COG0110	maltose O-acetyltransferase activity
IV89_RS01505	COG0463	Glycosyl transferase, family 2
IV89_RS01520	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IV89_RS01525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IV89_RS01540	COG0653	protein targeting
IV89_RS01545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IV89_RS01550	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IV89_RS01555	COG0494	nUDIX hydrolase
IV89_RS01560	COG1803	Methylglyoxal synthase
IV89_RS01560	COG1597	lipid kinase activity
IV89_RS01570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IV89_RS01585	COG0779	Required for maturation of 30S ribosomal subunits
IV89_RS01600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IV89_RS01610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IV89_RS01625	COG2226	methyltransferase
IV89_RS01650	COG3034	peptidoglycan biosynthetic process
IV89_RS01660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IV89_RS01665	COG1132	(ABC) transporter
IV89_RS01670	COG1132	(ABC) transporter
IV89_RS01675	COG0617	tRNA 3'-terminal CCA addition
IV89_RS01680	COG0494	nUDIX hydrolase
IV89_RS01705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IV89_RS01710	COG0137	argininosuccinate synthase activity
IV89_RS01725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IV89_RS01730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IV89_RS01740	COG0280	phosphate acetyltransferase
IV89_RS01740	COG0281	malic enzyme
IV89_RS01745	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IV89_RS01750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IV89_RS01760	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IV89_RS01765	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IV89_RS01770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IV89_RS01785	COG0357	Ribosomal RNA small subunit methyltransferase G
IV89_RS01790	COG0445	tRNA wobble uridine modification
IV89_RS01795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IV89_RS01800	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IV89_RS01805	COG1981	membrane
IV89_RS01810	COG0424	maF-like protein
IV89_RS01820	COG0237	dephospho-CoA kinase activity
IV89_RS01825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IV89_RS01830	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IV89_RS01860	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IV89_RS01865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IV89_RS01880	COG1074	ATP-dependent DNA helicase activity
IV89_RS01890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IV89_RS01895	COG3178	'Phosphotransferase
IV89_RS01900	COG0802	atpase or kinase
IV89_RS01905	COG2205	protein histidine kinase activity
IV89_RS01915	COG1999	signal sequence binding
IV89_RS01920	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IV89_RS01930	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IV89_RS01940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IV89_RS01950	COG2115	Belongs to the xylose isomerase family
IV89_RS01955	COG1070	Carbohydrate kinase
IV89_RS01960	COG1129	ABC transporter
IV89_RS01965	COG4214	carbohydrate transport
IV89_RS01970	COG4213	ABC transporter substrate-binding protein
IV89_RS01975	COG1940	carbohydrate kinase activity
IV89_RS01985	COG1858	cytochrome C peroxidase
IV89_RS02000	COG2350	Protein conserved in bacteria
IV89_RS02005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IV89_RS02010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IV89_RS02040	COG3474	cytochrome
IV89_RS02045	COG3191	aminopeptidase activity
IV89_RS02055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IV89_RS02075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IV89_RS02110	COG0747	negative chemotaxis
IV89_RS02115	COG0443	Heat shock 70 kDa protein
IV89_RS02120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IV89_RS02130	COG2116	formate transmembrane transporter activity
IV89_RS02135	COG1295	ribonuclease BN
IV89_RS02160	COG0784	Response regulator, receiver
IV89_RS02185	COG1396	sequence-specific DNA binding
IV89_RS02190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IV89_RS02195	COG0069	glutamate synthase activity
IV89_RS02230	COG0693	protein deglycase activity
IV89_RS02240	COG2995	paraquat-inducible protein a
IV89_RS02245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IV89_RS02245	COG3008	intermembrane lipid transfer
IV89_RS02255	COG0489	protein tyrosine kinase activity
IV89_RS02255	COG3206	protein involved in exopolysaccharide biosynthesis
IV89_RS02275	COG2003	Belongs to the UPF0758 family
IV89_RS02280	COG0484	heat shock protein binding
IV89_RS02285	COG0443	Heat shock 70 kDa protein
IV89_RS02305	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IV89_RS02315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IV89_RS02340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IV89_RS02345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IV89_RS02350	COG1137	ATPase activity
IV89_RS02365	COG0517	IMP dehydrogenase activity
IV89_RS02365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IV89_RS02380	COG2030	dehydratase
IV89_RS02380	COG1012	belongs to the aldehyde dehydrogenase family
IV89_RS02385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IV89_RS02390	COG2151	metal-sulfur cluster biosynthetic enzyme
IV89_RS02395	COG3396	Phenylacetate-CoA oxygenase
IV89_RS02400	COG3460	Phenylacetate-CoA oxygenase
IV89_RS02405	COG3396	Phenylacetate-CoA oxygenase
IV89_RS02410	COG0183	Belongs to the thiolase family
IV89_RS02415	COG0560	Phosphoserine phosphatase
IV89_RS02430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IV89_RS02445	COG2171	N-acyltransferase activity
IV89_RS02460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IV89_RS02475	COG0557	exoribonuclease II activity
IV89_RS02480	COG2951	lytic endotransglycosylase activity
IV89_RS02500	COG3842	ATPase activity
IV89_RS02510	COG1802	Transcriptional regulator
IV89_RS02520	COG3842	ATPase activity
IV89_RS02525	COG1176	ABC-type spermidine putrescine transport system, permease component I
IV89_RS02530	COG1177	transmembrane transport
IV89_RS02535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IV89_RS02540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IV89_RS02545	COG1054	Belongs to the UPF0176 family
IV89_RS02550	COG1335	isochorismatase
IV89_RS02555	COG2095	MarC family integral membrane protein
IV89_RS02560	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IV89_RS02575	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IV89_RS02585	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IV89_RS02605	COG0514	ATP-dependent DNA helicase (RecQ)
IV89_RS02610	COG3022	response to hydroperoxide
IV89_RS02615	COG0784	Response regulator, receiver
IV89_RS02615	COG2205	protein histidine kinase activity
IV89_RS02615	COG5002	protein histidine kinase activity
IV89_RS02635	COG0714	Associated with various cellular activities
IV89_RS02645	COG3622	Belongs to the hyi family
IV89_RS02650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IV89_RS02650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IV89_RS02665	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IV89_RS02675	COG0793	Belongs to the peptidase S41A family
IV89_RS02680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IV89_RS02685	COG0569	domain protein
IV89_RS02705	COG0129	dihydroxy-acid dehydratase activity
IV89_RS02710	COG2274	protein secretion by the type I secretion system
IV89_RS02720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IV89_RS02725	COG0285	dihydrofolate synthase activity
IV89_RS02735	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IV89_RS02745	COG0596	Alpha beta hydrolase
IV89_RS02750	COG2423	ornithine cyclodeaminase activity
IV89_RS02760	COG1671	Belongs to the UPF0178 family
IV89_RS02765	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IV89_RS02770	COG0679	Auxin Efflux Carrier
IV89_RS02785	COG2050	protein possibly involved in aromatic compounds catabolism
IV89_RS02795	COG0791	NLP P60 protein
IV89_RS02800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IV89_RS02810	COG0288	reversible hydration of carbon dioxide
IV89_RS02820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IV89_RS02840	COG0129	dihydroxy-acid dehydratase activity
IV89_RS02855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IV89_RS02860	COG1609	Transcriptional regulator
IV89_RS02880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IV89_RS02895	COG1194	a g-specific adenine glycosylase
IV89_RS02915	COG1663	tetraacyldisaccharide 4'-kinase activity
IV89_RS02920	COG1519	Transferase
IV89_RS02935	COG0312	modulator of DNA gyrase
IV89_RS02975	COG0495	leucyl-tRNA aminoacylation
IV89_RS02990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IV89_RS03005	COG0745	RESPONSE REGULATOR receiver
IV89_RS03010	COG0708	Exodeoxyribonuclease III
IV89_RS03025	COG2835	tetraacyldisaccharide 4'-kinase activity
IV89_RS03030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IV89_RS03035	COG0154	amidase activity
IV89_RS03040	COG0436	Aminotransferase
IV89_RS03045	COG1674	ftsk spoiiie
IV89_RS03070	COG0405	Gamma-glutamyltransferase
IV89_RS03080	COG1366	Belongs to the anti-sigma-factor antagonist family
IV89_RS03085	COG0183	Belongs to the thiolase family
IV89_RS03110	COG0564	pseudouridine synthase activity
IV89_RS03120	COG0450	alkyl hydroperoxide reductase
IV89_RS03135	COG3842	ATPase activity
IV89_RS03150	COG0437	4 iron, 4 sulfur cluster binding
IV89_RS03155	COG0243	molybdopterin cofactor binding
IV89_RS03155	COG3383	formate dehydrogenase (NAD+) activity
IV89_RS03190	COG0489	protein tyrosine kinase activity
IV89_RS03220	COG1185	polyribonucleotide nucleotidyltransferase activity
IV89_RS03230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IV89_RS03245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IV89_RS03250	COG3698	Phosphodiester glycosidase
IV89_RS03255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IV89_RS03260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IV89_RS03275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IV89_RS03275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IV89_RS03285	COG0138	bifunctional purine biosynthesis protein purh
IV89_RS03300	COG0612	Peptidase, M16
IV89_RS03305	COG0612	Peptidase, M16
IV89_RS03310	COG1012	belongs to the aldehyde dehydrogenase family
IV89_RS03320	COG2351	hydroxyisourate hydrolase activity
IV89_RS03330	COG3257	ureidoglycine aminohydrolase activity
IV89_RS03335	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IV89_RS03390	COG0625	glutathione transferase activity
IV89_RS03400	COG3383	formate dehydrogenase (NAD+) activity
IV89_RS03440	COG0559	Belongs to the binding-protein-dependent transport system permease family
IV89_RS03460	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IV89_RS03465	COG1178	ABC-type Fe3 transport system permease component
IV89_RS03470	COG1840	ABC-type Fe3 transport system, periplasmic component
IV89_RS03475	COG0625	glutathione transferase activity
IV89_RS03480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IV89_RS03495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IV89_RS03500	COG0284	orotidine-5'-phosphate decarboxylase activity
IV89_RS03515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IV89_RS03520	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IV89_RS03570	COG4221	oxidoreductase activity
IV89_RS03575	COG1309	transcriptional regulator
IV89_RS03590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IV89_RS03600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IV89_RS03605	COG0268	Binds directly to 16S ribosomal RNA
IV89_RS03610	COG1024	Enoyl-CoA hydratase
IV89_RS03615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IV89_RS03620	COG2226	methyltransferase
IV89_RS03630	COG1396	sequence-specific DNA binding
IV89_RS03635	COG0156	8-amino-7-oxononanoate synthase activity
IV89_RS03640	COG1063	alcohol dehydrogenase
IV89_RS03645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IV89_RS03650	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IV89_RS03665	COG1216	Glycosyl transferase, family 2
IV89_RS03695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IV89_RS03695	COG1648	precorrin-2 dehydrogenase activity
IV89_RS03700	COG1797	cobyrinic acid a,c-diamide synthase activity
IV89_RS03705	COG2875	Belongs to the precorrin methyltransferase family
IV89_RS03720	COG2099	Precorrin-6x reductase
IV89_RS03760	COG1492	cobalamin metabolic process
IV89_RS03765	COG1268	BioY protein
IV89_RS03775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IV89_RS03805	COG1250	3-hydroxyacyl-CoA dehydrogenase
IV89_RS03810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IV89_RS03820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IV89_RS03830	COG2321	neutral zinc metallopeptidase
IV89_RS03840	COG2816	NAD+ diphosphatase activity
IV89_RS03850	COG0077	Prephenate dehydratase
IV89_RS03865	COG4174	ABC transporter (Permease)
IV89_RS03870	COG4239	(ABC) transporter, permease
IV89_RS03875	COG4172	Belongs to the ABC transporter superfamily
IV89_RS03880	COG1686	Belongs to the peptidase S11 family
IV89_RS03890	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IV89_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS03905	COG0408	coproporphyrinogen oxidase activity
IV89_RS03910	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IV89_RS03915	COG0181	hydroxymethylbilane synthase activity
IV89_RS03920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IV89_RS03950	COG0179	Fumarylacetoacetate (FAA) hydrolase
IV89_RS03960	COG2151	metal-sulfur cluster biosynthetic enzyme
IV89_RS03960	COG0489	protein tyrosine kinase activity
IV89_RS03970	COG0254	rRNA binding
IV89_RS03975	COG0335	large ribosomal subunit rRNA binding
IV89_RS03980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IV89_RS03985	COG0336	Belongs to the RNA methyltransferase TrmD family
IV89_RS03990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IV89_RS03995	COG0228	four-way junction DNA binding
IV89_RS04005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IV89_RS04010	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IV89_RS04035	COG0356	it plays a direct role in the translocation of protons across the membrane
IV89_RS04040	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IV89_RS04045	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IV89_RS04050	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IV89_RS04070	COG0435	Glutathione S-transferase
IV89_RS04080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IV89_RS04085	COG0242	peptide deformylase activity
IV89_RS04090	COG0242	peptide deformylase activity
IV89_RS04095	COG0242	peptide deformylase activity
IV89_RS04100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IV89_RS04110	COG2860	membrane
IV89_RS04115	COG0328	RNA-DNA hybrid ribonuclease activity
IV89_RS04125	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IV89_RS04135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IV89_RS04140	COG1758	RNA polymerase activity
IV89_RS04145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IV89_RS04155	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IV89_RS04160	COG0736	holo-[acyl-carrier-protein] synthase activity
IV89_RS04165	COG0681	Belongs to the peptidase S26 family
IV89_RS04170	COG0571	ribonuclease III activity
IV89_RS04175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IV89_RS04185	COG1381	Involved in DNA repair and RecF pathway recombination
IV89_RS04205	COG1396	sequence-specific DNA binding
IV89_RS04220	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IV89_RS04225	COG0745	RESPONSE REGULATOR receiver
IV89_RS04230	COG2205	protein histidine kinase activity
IV89_RS04240	COG1660	Displays ATPase and GTPase activities
IV89_RS04250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IV89_RS04260	COG1250	3-hydroxyacyl-CoA dehydrogenase
IV89_RS04280	COG2096	Adenosyltransferase
IV89_RS04290	COG0300	oxidoreductase activity
IV89_RS04300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IV89_RS04325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IV89_RS04340	COG0250	Participates in transcription elongation, termination and antitermination
IV89_RS04345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IV89_RS04350	COG0081	regulation of translation
IV89_RS04355	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IV89_RS04360	COG0222	ribosome binding
IV89_RS04365	COG0085	RNA polymerase activity
IV89_RS04370	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IV89_RS04375	COG0697	spore germination
IV89_RS04385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IV89_RS04390	COG0049	tRNA binding
IV89_RS04395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IV89_RS04400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IV89_RS04405	COG0051	transcription antitermination factor activity, RNA binding
IV89_RS04410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IV89_RS04415	COG0088	Forms part of the polypeptide exit tunnel
IV89_RS04420	COG0089	rRNA binding
IV89_RS04430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IV89_RS04435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IV89_RS04440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IV89_RS04445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IV89_RS04450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IV89_RS04470	COG0255	Belongs to the universal ribosomal protein uL29 family
IV89_RS04475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IV89_RS04480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IV89_RS04485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IV89_RS04490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IV89_RS04495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IV89_RS04500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IV89_RS04505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IV89_RS04510	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IV89_RS04515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IV89_RS04520	COG1841	ribosomal large subunit assembly
IV89_RS04525	COG0200	Binds to the 23S rRNA
IV89_RS04530	COG0201	protein transport
IV89_RS04535	COG0563	adenylate kinase activity
IV89_RS04540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IV89_RS04545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IV89_RS04550	COG0202	RNA polymerase activity
IV89_RS04555	COG0203	ribosomal protein L17
IV89_RS04560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IV89_RS04565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IV89_RS04570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IV89_RS04585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IV89_RS04590	COG4597	amino acid ABC transporter
IV89_RS04595	COG0765	amino acid transport
IV89_RS04600	COG1126	abc transporter atp-binding protein
IV89_RS04610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IV89_RS04615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IV89_RS04625	COG0706	membrane insertase activity
IV89_RS04635	COG0037	tRNA processing
IV89_RS04640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IV89_RS04645	COG0594	ribonuclease P activity
IV89_RS04650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IV89_RS04660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IV89_RS04665	COG2205	protein histidine kinase activity
IV89_RS04680	COG0019	diaminopimelate decarboxylase activity
IV89_RS04710	COG0174	glutamine synthetase
IV89_RS04735	COG2205	protein histidine kinase activity
IV89_RS04740	COG1271	oxidase subunit
IV89_RS04745	COG1294	oxidase, subunit
IV89_RS04755	COG0604	alcohol dehydrogenase
IV89_RS04755	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS04755	COG3321	synthase
IV89_RS04765	COG1131	(ABC) transporter
IV89_RS04770	COG0842	Transport permease protein
IV89_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS04790	COG0322	excinuclease ABC activity
IV89_RS04795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IV89_RS04805	COG0314	molybdopterin synthase activity
IV89_RS04815	COG2885	chlorophyll binding
IV89_RS04820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IV89_RS04825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IV89_RS04845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IV89_RS04870	COG0540	Belongs to the ATCase OTCase family
IV89_RS04875	COG1573	uracil-dna glycosylase
IV89_RS04880	COG1280	lysine exporter protein (LysE YggA)
IV89_RS04885	COG0521	Mo-molybdopterin cofactor biosynthetic process
IV89_RS04895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IV89_RS04905	COG1678	Uncharacterized ACR, COG1678
IV89_RS04910	COG0009	L-threonylcarbamoyladenylate synthase
IV89_RS04915	COG1960	acyl-CoA dehydrogenase activity
IV89_RS04965	COG0303	'Molybdopterin
IV89_RS04975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IV89_RS04985	COG0789	Transcriptional regulator
IV89_RS05000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IV89_RS05005	COG0142	geranyltranstransferase activity
IV89_RS05040	COG0519	Catalyzes the synthesis of GMP from XMP
IV89_RS05045	COG0745	RESPONSE REGULATOR receiver
IV89_RS05050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IV89_RS05055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IV89_RS05060	COG0287	Prephenate dehydrogenase
IV89_RS05075	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IV89_RS05100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IV89_RS05110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IV89_RS05115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IV89_RS05120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IV89_RS05125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IV89_RS05130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IV89_RS05160	COG2983	Belongs to the UPF0260 family
IV89_RS05165	COG0196	riboflavin kinase activity
IV89_RS05170	COG2030	dehydratase
IV89_RS05190	COG1227	inorganic diphosphatase activity
IV89_RS05200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IV89_RS05205	COG0459	protein refolding
IV89_RS05225	COG3454	Phosphonate metabolism
IV89_RS05230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IV89_RS05255	COG2046	Belongs to the sulfate adenylyltransferase family
IV89_RS05255	COG0529	Catalyzes the synthesis of activated sulfate
IV89_RS05260	COG0492	ferredoxin-NADP+ reductase activity
IV89_RS05265	COG1522	sequence-specific DNA binding
IV89_RS05280	COG1496	oxidoreductase activity
IV89_RS05290	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IV89_RS05310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IV89_RS05320	COG1435	thymidine kinase activity
IV89_RS05330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IV89_RS05335	COG0596	Alpha beta hydrolase
IV89_RS05345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IV89_RS05350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IV89_RS05355	COG3237	CsbD-like
IV89_RS05370	COG0280	phosphate acetyltransferase
IV89_RS05370	COG0281	malic enzyme
IV89_RS05380	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IV89_RS05385	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IV89_RS05390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IV89_RS05410	COG0318	PFAM AMP-dependent synthetase and ligase
IV89_RS05430	COG0183	Belongs to the thiolase family
IV89_RS05435	COG0625	glutathione transferase activity
IV89_RS05445	COG1960	acyl-CoA dehydrogenase activity
IV89_RS05450	COG0789	Transcriptional regulator
IV89_RS05455	COG2197	response regulator
IV89_RS05480	COG0534	Mate efflux family protein
IV89_RS05500	COG0737	Belongs to the 5'-nucleotidase family
IV89_RS05510	COG0583	DNA-binding transcription factor activity
IV89_RS05515	COG1960	acyl-CoA dehydrogenase activity
IV89_RS05520	COG4948	Mandelate Racemase Muconate Lactonizing
IV89_RS05545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IV89_RS05565	COG1047	Peptidyl-prolyl cis-trans
IV89_RS05575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IV89_RS05580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IV89_RS05585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IV89_RS05600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IV89_RS05615	COG1702	phosphate starvation-inducible protein PhoH
IV89_RS05620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IV89_RS05625	COG1253	flavin adenine dinucleotide binding
IV89_RS05630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IV89_RS05635	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IV89_RS05640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IV89_RS05650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IV89_RS05655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IV89_RS05660	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IV89_RS05670	COG0539	negative regulation of cytoplasmic translation
IV89_RS05675	COG0776	regulation of translation
IV89_RS05685	COG0135	phosphoribosylanthranilate isomerase activity
IV89_RS05690	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IV89_RS05730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IV89_RS05735	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IV89_RS05740	COG0659	secondary active sulfate transmembrane transporter activity
IV89_RS05765	COG4149	molybdate abc transporter
IV89_RS05770	COG0725	ABC transporter, periplasmic molybdate-binding protein
IV89_RS05785	COG0527	aspartate kinase activity
IV89_RS05795	COG1454	alcohol dehydrogenase
IV89_RS05805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IV89_RS05840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IV89_RS05845	COG0354	folic acid binding
IV89_RS05855	COG1132	(ABC) transporter
IV89_RS05870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IV89_RS05880	COG0525	valine-tRNA ligase activity
IV89_RS05900	COG0583	DNA-binding transcription factor activity
IV89_RS05915	COG2130	NADP-dependent
IV89_RS05920	COG0483	inositol monophosphate 1-phosphatase activity
IV89_RS05940	COG1522	sequence-specific DNA binding
IV89_RS05985	COG3750	Belongs to the UPF0335 family
IV89_RS06055	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
IV89_RS06275	COG5002	protein histidine kinase activity
IV89_RS06280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IV89_RS06290	COG0667	Aldo Keto reductase
IV89_RS06295	COG3246	L-lysine catabolic process to acetate
IV89_RS06305	COG0824	Thioesterase
IV89_RS06305	COG1250	3-hydroxyacyl-CoA dehydrogenase
IV89_RS06330	COG1595	DNA-templated transcription, initiation
IV89_RS06365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IV89_RS06375	COG0358	DNA primase activity
IV89_RS06380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IV89_RS06395	COG0432	Pfam Uncharacterised protein family UPF0047
IV89_RS06400	COG4221	oxidoreductase activity
IV89_RS06405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IV89_RS06410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IV89_RS06410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IV89_RS06440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IV89_RS06440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IV89_RS06445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IV89_RS06450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IV89_RS06485	COG0564	pseudouridine synthase activity
IV89_RS06500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IV89_RS06510	COG1793	dna ligase
IV89_RS06520	COG2267	carboxylic ester hydrolase activity
IV89_RS06540	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IV89_RS06545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IV89_RS06550	COG1329	Transcriptional regulator
IV89_RS06580	COG2873	o-acetylhomoserine
IV89_RS06595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IV89_RS06605	COG1832	CoA-binding protein
IV89_RS06610	COG0140	phosphoribosyl-ATP diphosphatase activity
IV89_RS06615	COG0107	imidazoleglycerol-phosphate synthase activity
IV89_RS06620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IV89_RS06635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IV89_RS06640	COG0131	Imidazoleglycerol-phosphate dehydratase
IV89_RS06675	COG0321	lipoyl(octanoyl) transferase activity
IV89_RS06695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IV89_RS06720	COG0729	surface antigen
IV89_RS06740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IV89_RS06760	COG0628	permease
IV89_RS06765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IV89_RS06770	COG1120	ATPase activity
IV89_RS06795	COG1570	exodeoxyribonuclease VII activity
IV89_RS06805	COG3239	Fatty acid desaturase
IV89_RS06810	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IV89_RS06820	COG0552	protein localization to endoplasmic reticulum
IV89_RS06830	COG2917	probably involved in intracellular septation
IV89_RS06840	COG1469	GTP cyclohydrolase I activity
IV89_RS06850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IV89_RS06865	COG0752	glycyl-tRNA synthetase alpha subunit
IV89_RS06875	COG0751	glycine-tRNA ligase activity
IV89_RS06880	COG0574	Belongs to the PEP-utilizing enzyme family
IV89_RS06880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IV89_RS06890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IV89_RS06895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IV89_RS06900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IV89_RS06910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IV89_RS06920	COG1522	sequence-specific DNA binding
IV89_RS06930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IV89_RS06940	COG1802	Transcriptional regulator
IV89_RS06950	COG0505	Belongs to the CarA family
IV89_RS06955	COG1610	YqeY-like protein
IV89_RS06965	COG0346	lactoylglutathione lyase activity
IV89_RS06970	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IV89_RS06985	COG0489	protein tyrosine kinase activity
IV89_RS06990	COG2001	Belongs to the MraZ family
IV89_RS06995	COG0275	rRNA processing
IV89_RS07010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IV89_RS07020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IV89_RS07025	COG2066	Belongs to the glutaminase family
IV89_RS07030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IV89_RS07055	COG1231	oxidoreductase activity
IV89_RS07060	COG2814	Major facilitator Superfamily
IV89_RS07070	COG2081	HI0933 family
IV89_RS07085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IV89_RS07090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IV89_RS07110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IV89_RS07115	COG1181	Belongs to the D-alanine--D-alanine ligase family
IV89_RS07120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IV89_RS07125	COG0849	cell division
IV89_RS07130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IV89_RS07140	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IV89_RS07165	COG0006	proline dipeptidase activity
IV89_RS07180	COG0484	heat shock protein binding
IV89_RS07200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IV89_RS07220	COG0308	aminopeptidase N
IV89_RS07235	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IV89_RS07255	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS07265	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IV89_RS07270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IV89_RS07270	COG3453	Protein conserved in bacteria
IV89_RS07285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IV89_RS07290	COG0601	transmembrane transport
IV89_RS07300	COG4172	Belongs to the ABC transporter superfamily
IV89_RS07305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IV89_RS07310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IV89_RS07315	COG1473	amidohydrolase
IV89_RS07320	COG1473	amidohydrolase
IV89_RS07325	COG0438	transferase activity, transferring glycosyl groups
IV89_RS07330	COG1519	Transferase
IV89_RS07335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IV89_RS07355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IV89_RS07360	COG0546	phosphoglycolate phosphatase activity
IV89_RS07370	COG0346	lactoylglutathione lyase activity
IV89_RS07380	COG1960	acyl-CoA dehydrogenase activity
IV89_RS07390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IV89_RS07395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IV89_RS07415	COG1024	Enoyl-CoA hydratase
IV89_RS07420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IV89_RS07430	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IV89_RS07435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IV89_RS07445	COG0649	NAD binding
IV89_RS07455	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IV89_RS07455	COG3743	rRNA binding
IV89_RS07495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IV89_RS07500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IV89_RS07515	COG0713	ATP synthesis coupled electron transport
IV89_RS07530	COG1007	ATP synthesis coupled electron transport
IV89_RS07540	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IV89_RS07550	COG0513	Belongs to the DEAD box helicase family
IV89_RS07560	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IV89_RS07575	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS07585	COG3842	ATPase activity
IV89_RS07595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IV89_RS07600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IV89_RS07605	COG0805	protein transport
IV89_RS07620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IV89_RS07625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IV89_RS07630	COG4221	oxidoreductase activity
IV89_RS07640	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IV89_RS07665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IV89_RS07680	COG0305	Participates in initiation and elongation during chromosome replication
IV89_RS07685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IV89_RS07690	COG0418	dihydroorotase activity
IV89_RS07700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IV89_RS07710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IV89_RS07730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IV89_RS07735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IV89_RS07740	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IV89_RS07755	COG1138	Cytochrome C-type biogenesis protein
IV89_RS07760	COG3088	subunit of a heme lyase
IV89_RS07765	COG1024	Enoyl-CoA hydratase
IV89_RS07775	COG0372	Belongs to the citrate synthase family
IV89_RS07780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IV89_RS07785	COG0658	competence protein
IV89_RS07785	COG2333	competence protein COMEC
IV89_RS07790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IV89_RS07795	COG0303	'Molybdopterin
IV89_RS07800	COG0315	cyclic pyranopterin monophosphate synthase activity
IV89_RS07805	COG0134	indole-3-glycerol-phosphate synthase activity
IV89_RS07810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IV89_RS07815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IV89_RS07835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IV89_RS07845	COG0436	Aminotransferase
IV89_RS07850	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IV89_RS07855	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IV89_RS07860	COG0259	pyridoxamine-phosphate oxidase activity
IV89_RS07865	COG1278	Cold shock
IV89_RS07880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IV89_RS07885	COG1522	sequence-specific DNA binding
IV89_RS07900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IV89_RS07915	COG0215	cysteine-tRNA ligase activity
IV89_RS07920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IV89_RS07930	COG2814	Major facilitator Superfamily
IV89_RS07970	COG0316	Belongs to the HesB IscA family
IV89_RS07975	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IV89_RS07980	COG0018	arginyl-trna synthetase
IV89_RS07990	COG1472	Belongs to the glycosyl hydrolase 3 family
IV89_RS07995	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IV89_RS08000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IV89_RS08010	COG0717	Belongs to the dCTP deaminase family
IV89_RS08025	COG0776	regulation of translation
IV89_RS08030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IV89_RS08035	COG0416	fatty acid biosynthetic process
IV89_RS08040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IV89_RS08060	COG0488	(ABC) transporter
IV89_RS08065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IV89_RS08070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IV89_RS08080	COG0148	phosphopyruvate hydratase activity
IV89_RS08095	COG0513	Belongs to the DEAD box helicase family
IV89_RS08100	COG2814	Major facilitator Superfamily
IV89_RS08125	COG4166	transmembrane transport
IV89_RS08130	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS08145	COG2313	pseudouridylate synthase activity
IV89_RS08150	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IV89_RS08150	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IV89_RS08175	COG1612	heme a metabolic process
IV89_RS08180	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IV89_RS08190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IV89_RS08205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IV89_RS08210	COG0363	glucosamine-6-phosphate deaminase activity
IV89_RS08215	COG0166	Belongs to the GPI family
IV89_RS08230	COG0318	PFAM AMP-dependent synthetase and ligase
IV89_RS08235	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IV89_RS08240	COG0602	queuosine metabolic process
IV89_RS08245	COG0720	synthase
IV89_RS08250	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IV89_RS08255	COG0702	epimerase
IV89_RS08265	COG0754	glutathionylspermidine amidase activity
IV89_RS08275	COG1012	belongs to the aldehyde dehydrogenase family
IV89_RS08280	COG2202	Pas domain
IV89_RS08280	COG2205	protein histidine kinase activity
IV89_RS08290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IV89_RS08295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IV89_RS08300	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IV89_RS08310	COG2166	iron-sulfur cluster assembly
IV89_RS08320	COG5012	cobalamin binding
IV89_RS08330	COG0646	methionine synthase
IV89_RS08330	COG1410	methionine synthase
IV89_RS08335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IV89_RS08340	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IV89_RS08345	COG0047	phosphoribosylformylglycinamidine synthase activity
IV89_RS08365	COG1530	ribonuclease E activity
IV89_RS08370	COG0425	Belongs to the sulfur carrier protein TusA family
IV89_RS08375	COG0785	Cytochrome C biogenesis protein
IV89_RS08390	COG3588	fructose-bisphosphate aldolase
IV89_RS08410	COG0114	fumarate hydratase activity
IV89_RS08440	COG0604	alcohol dehydrogenase
IV89_RS08445	COG0415	Belongs to the DNA photolyase family
IV89_RS08450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IV89_RS08460	COG0494	nUDIX hydrolase
IV89_RS08470	COG3264	Mechanosensitive ion channel
IV89_RS08470	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IV89_RS08475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IV89_RS08485	COG1238	metal cluster binding
IV89_RS08495	COG3409	Peptidoglycan-binding domain 1 protein
IV89_RS08495	COG3267	Type II secretory pathway component ExeA
IV89_RS08500	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IV89_RS08520	COG0433	COG0433 Predicted ATPase
IV89_RS08560	COG2133	pyrroloquinoline quinone binding
IV89_RS08570	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IV89_RS08580	COG1561	YicC-like family, N-terminal region
IV89_RS08585	COG0194	GDP metabolic process
IV89_RS08595	COG5002	protein histidine kinase activity
IV89_RS08605	COG0573	inorganic phosphate transmembrane transporter activity
IV89_RS08615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IV89_RS08625	COG0745	RESPONSE REGULATOR receiver
IV89_RS08630	COG0179	Fumarylacetoacetate (FAA) hydrolase
IV89_RS08640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IV89_RS08645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IV89_RS08650	COG0052	Belongs to the universal ribosomal protein uS2 family
IV89_RS08675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IV89_RS08680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IV89_RS08685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IV89_RS08705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IV89_RS08710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IV89_RS08710	COG3743	rRNA binding
IV89_RS08735	COG0588	phosphoglycerate mutase activity
IV89_RS08750	COG1176	ABC-type spermidine putrescine transport system, permease component I
IV89_RS08755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IV89_RS08765	COG1126	abc transporter atp-binding protein
IV89_RS08800	COG0105	UTP biosynthetic process
IV89_RS08805	COG0488	(ABC) transporter
IV89_RS08810	COG2095	MarC family integral membrane protein
IV89_RS08815	COG3577	Aspartyl protease
IV89_RS08825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IV89_RS08840	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IV89_RS08845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IV89_RS08850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IV89_RS08855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IV89_RS08865	COG2890	protein-(glutamine-N5) methyltransferase activity
IV89_RS08870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IV89_RS08885	COG0010	Belongs to the arginase family
IV89_RS08890	COG1473	amidohydrolase
IV89_RS08895	COG3956	TIGRFAM MazG family protein
IV89_RS08910	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IV89_RS08920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IV89_RS08940	COG2084	Dehydrogenase
IV89_RS08960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IV89_RS08965	COG1923	regulation of RNA biosynthetic process
IV89_RS08975	COG0569	domain protein
IV89_RS08985	COG2204	response regulator
IV89_RS08990	COG5000	phosphorelay sensor kinase activity
IV89_RS08995	COG2204	response regulator
IV89_RS09000	COG3852	Histidine kinase
IV89_RS09005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IV89_RS09010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IV89_RS09010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IV89_RS09015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IV89_RS09025	COG0004	ammonium transporteR
IV89_RS09030	COG2867	negative regulation of translational initiation
IV89_RS09035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IV89_RS09045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IV89_RS09060	COG5598	trimethylamine methyltransferase
IV89_RS09065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IV89_RS09065	COG0519	Catalyzes the synthesis of GMP from XMP
IV89_RS09070	COG0697	spore germination
IV89_RS09085	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IV89_RS09090	COG0596	Alpha beta hydrolase
IV89_RS09095	COG2326	polyphosphate kinase activity
IV89_RS09100	COG1309	transcriptional regulator
IV89_RS09105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IV89_RS09110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IV89_RS09115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IV89_RS09120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IV89_RS09140	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IV89_RS09145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IV89_RS09150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IV89_RS09160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IV89_RS09165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IV89_RS09180	COG0482	sulfurtransferase activity
IV89_RS09185	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IV89_RS09190	COG3494	Protein of unknown function (DUF1009)
IV89_RS09195	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IV89_RS09200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IV89_RS09210	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IV89_RS09215	COG0750	zinc metalloprotease
IV89_RS09220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IV89_RS09230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IV89_RS09235	COG0233	cytoplasmic translational termination
IV89_RS09240	COG0528	UMP kinase activity
IV89_RS09245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IV89_RS09255	COG0601	transmembrane transport
IV89_RS09260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IV89_RS09275	COG1196	nuclear chromosome segregation
IV89_RS09275	COG0741	lytic transglycosylase activity
IV89_RS09275	COG0739	heme binding
IV89_RS09280	COG0629	single-stranded DNA binding
IV89_RS09285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IV89_RS09290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IV89_RS09305	COG4974	Belongs to the 'phage' integrase family
IV89_RS09315	COG4536	flavin adenine dinucleotide binding
IV89_RS09345	COG1175	transmembrane transport
IV89_RS09450	COG1238	metal cluster binding
IV89_RS09465	COG0010	Belongs to the arginase family
IV89_RS09475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IV89_RS09505	COG1764	response to oxidative stress
IV89_RS09510	COG0501	Belongs to the peptidase M48B family
IV89_RS09535	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IV89_RS09550	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IV89_RS09565	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IV89_RS09580	COG0028	Belongs to the TPP enzyme family
IV89_RS09585	COG0440	acetolactate synthase activity
IV89_RS09605	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IV89_RS09610	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IV89_RS09620	COG0436	Aminotransferase
IV89_RS09645	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IV89_RS09655	COG0156	8-amino-7-oxononanoate synthase activity
IV89_RS09660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IV89_RS09675	COG1320	monovalent cation:proton antiporter activity
IV89_RS09680	COG2212	antiporter activity
IV89_RS09685	COG1863	multisubunit Na H antiporter MnhE subunit
IV89_RS09690	COG0651	ATP synthesis coupled electron transport
IV89_RS09695	COG1006	Multisubunit Na H antiporter MnhC subunit
IV89_RS09700	COG2111	Na H antiporter
IV89_RS09700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IV89_RS09705	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IV89_RS09710	COG0248	Ppx GppA phosphatase
IV89_RS09720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IV89_RS09730	COG2205	protein histidine kinase activity
IV89_RS09730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IV89_RS09730	COG2198	Histidine kinase
IV89_RS09730	COG0784	Response regulator, receiver
IV89_RS09740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IV89_RS09755	COG0719	Fe-S assembly protein
IV89_RS09760	COG0396	ATPase activity
IV89_RS09775	COG0719	Fe-S assembly protein
IV89_RS09785	COG1959	2 iron, 2 sulfur cluster binding
IV89_RS09790	COG2945	thiolester hydrolase activity
IV89_RS09805	COG0538	isocitrate dehydrogenase activity
IV89_RS09815	COG2076	Multidrug Resistance protein
IV89_RS09820	COG0668	transmembrane transport
IV89_RS09825	COG1217	gtp-binding protein TYPA
IV89_RS09835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IV89_RS09840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IV89_RS09855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IV89_RS10025	COG4681	YaeQ
IV89_RS10045	COG1473	amidohydrolase
IV89_RS10055	COG1732	Glycine betaine
IV89_RS10060	COG1174	glycine betaine transport
IV89_RS10065	COG1125	glycine betaine transport
IV89_RS10070	COG1174	glycine betaine transport
IV89_RS10080	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IV89_RS10090	COG1268	BioY protein
IV89_RS10095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IV89_RS10110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IV89_RS10130	COG0351	phosphomethylpyrimidine kinase
IV89_RS10145	COG2022	thiamine diphosphate biosynthetic process
IV89_RS10155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IV89_RS10160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IV89_RS10165	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IV89_RS10170	COG1116	anion transmembrane transporter activity
IV89_RS10175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IV89_RS10180	COG1024	Enoyl-CoA hydratase
IV89_RS10190	COG0776	regulation of translation
IV89_RS10195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IV89_RS10200	COG1902	pentaerythritol trinitrate reductase activity
IV89_RS10205	COG0343	queuine tRNA-ribosyltransferase activity
IV89_RS10210	COG0189	ligase activity
IV89_RS10210	COG4067	protein conserved in archaea
IV89_RS10215	COG2151	metal-sulfur cluster biosynthetic enzyme
IV89_RS10225	COG0316	Belongs to the HesB IscA family
IV89_RS10230	COG0149	triose-phosphate isomerase activity
IV89_RS10235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IV89_RS10240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IV89_RS10245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IV89_RS10260	COG2124	cytochrome p450
IV89_RS10265	COG1522	sequence-specific DNA binding
IV89_RS10270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IV89_RS10270	COG1648	precorrin-2 dehydrogenase activity
IV89_RS10280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IV89_RS10285	COG0175	sulfate reduction
IV89_RS10305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IV89_RS10310	COG2885	chlorophyll binding
IV89_RS10335	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IV89_RS10350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IV89_RS10370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IV89_RS10380	COG2354	Protein conserved in bacteria
IV89_RS10400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IV89_RS10440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IV89_RS10445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IV89_RS10455	COG2814	Major facilitator Superfamily
IV89_RS10460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IV89_RS10470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IV89_RS10475	COG2833	Protein of unknown function (DUF455)
IV89_RS10480	COG0739	heme binding
IV89_RS10500	COG0126	phosphoglycerate kinase activity
IV89_RS10510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IV89_RS10515	COG0508	dehydrogenase complex catalyzes the overall conversion of
IV89_RS10515	COG0022	dehydrogenase e1 component
IV89_RS10520	COG0508	dehydrogenase complex catalyzes the overall conversion of
IV89_RS10600	COG4695	Portal protein
IV89_RS10610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IV89_RS10615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IV89_RS10625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IV89_RS10635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IV89_RS10640	COG3038	cytochrome b561
IV89_RS10645	COG2353	YceI-like domain
IV89_RS10655	COG0360	Binds together with S18 to 16S ribosomal RNA
IV89_RS10660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IV89_RS10665	COG0359	binds to the 23S rRNA
IV89_RS10680	COG0544	peptidyl-prolyl cis-trans isomerase activity
IV89_RS10685	COG3750	Belongs to the UPF0335 family
IV89_RS10720	COG0745	RESPONSE REGULATOR receiver
IV89_RS10725	COG1396	sequence-specific DNA binding
IV89_RS10725	COG3800	Transcriptional regulator
IV89_RS10750	COG0410	ABC transporter
IV89_RS10755	COG0511	ligase activity, forming carbon-carbon bonds
IV89_RS10760	COG0439	Biotin carboxylase
IV89_RS10765	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IV89_RS10785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IV89_RS10790	COG0740	serine-type endopeptidase activity
IV89_RS10820	COG1121	(ABC) transporter
IV89_RS10825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IV89_RS10850	COG0811	peptide transport
IV89_RS10865	COG1011	Hydrolase
IV89_RS10875	COG3639	organic phosphonate transmembrane transporter activity
IV89_RS10890	COG1349	DNA-binding transcription factor activity
IV89_RS10895	COG2205	protein histidine kinase activity
IV89_RS10895	COG2202	Pas domain
IV89_RS10915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IV89_RS10935	COG1686	Belongs to the peptidase S11 family
IV89_RS10940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IV89_RS10950	COG0084	hydrolase, TatD family'
IV89_RS10955	COG1234	tRNA 3'-trailer cleavage
IV89_RS10985	COG0544	peptidyl-prolyl cis-trans isomerase activity
IV89_RS10990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IV89_RS10990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IV89_RS11020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IV89_RS11030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IV89_RS11035	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IV89_RS11040	COG4133	protoheme IX ABC transporter activity
IV89_RS11045	COG3737	Protein of unknown function (DUF498/DUF598)
IV89_RS11050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IV89_RS11055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IV89_RS11060	COG1862	Preprotein translocase
IV89_RS11065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IV89_RS11075	COG1160	GTP binding
IV89_RS11095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IV89_RS11100	COG2814	Major facilitator Superfamily
IV89_RS11110	COG5265	(ABC) transporter
IV89_RS11145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IV89_RS11145	COG0446	pyridine nucleotide-disulphide oxidoreductase
IV89_RS11160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IV89_RS11165	COG4235	cytochrome complex assembly
IV89_RS11170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IV89_RS11185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IV89_RS11190	COG0730	response to heat
IV89_RS11195	COG1454	alcohol dehydrogenase
IV89_RS11205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IV89_RS11220	COG0395	ABC-type sugar transport system, permease component
IV89_RS11230	COG3842	ATPase activity
IV89_RS11235	COG3842	ATPase activity
IV89_RS11245	COG1349	DNA-binding transcription factor activity
IV89_RS11250	COG1175	transmembrane transport
IV89_RS11255	COG0395	ABC-type sugar transport system, permease component
IV89_RS11260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IV89_RS11265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IV89_RS11270	COG1121	(ABC) transporter
IV89_RS11290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IV89_RS11295	COG0330	HflC and HflK could
IV89_RS11300	COG0330	HflC and HflK could
IV89_RS11310	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IV89_RS11315	COG0625	glutathione transferase activity
IV89_RS11320	COG1760	l-serine dehydratase
IV89_RS11345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IV89_RS11360	COG2207	Transcriptional regulator
IV89_RS11360	COG3708	Transcriptional regulator
IV89_RS11380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IV89_RS11395	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IV89_RS11400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IV89_RS11405	COG0697	spore germination
IV89_RS11410	COG3448	diguanylate cyclase activity
IV89_RS11410	COG4175	Glycine betaine
IV89_RS11430	COG4608	Belongs to the ABC transporter superfamily
IV89_RS11435	COG0444	Belongs to the ABC transporter superfamily
IV89_RS11440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IV89_RS11445	COG0601	transmembrane transport
IV89_RS11455	COG0747	negative chemotaxis
IV89_RS11460	COG3620	sequence-specific DNA binding
IV89_RS11470	COG1215	transferase activity, transferring glycosyl groups
IV89_RS11490	COG0546	phosphoglycolate phosphatase activity
IV89_RS11525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IV89_RS11540	COG0504	CTP synthase activity
IV89_RS11545	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IV89_RS11575	COG4215	(ABC) transporter
IV89_RS11580	COG0765	amino acid transport
IV89_RS11585	COG0174	glutamine synthetase
IV89_RS11590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IV89_RS11590	COG0519	Catalyzes the synthesis of GMP from XMP
IV89_RS11595	COG0174	glutamine synthetase
IV89_RS11600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IV89_RS11605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IV89_RS11620	COG3243	poly(R)-hydroxyalkanoic acid synthase
IV89_RS11660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IV89_RS11670	COG3220	belongs to the UPF0276 family
IV89_RS11685	COG1393	Belongs to the ArsC family
IV89_RS11690	COG1278	Cold shock
IV89_RS11705	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IV89_RS11760	COG0534	Mate efflux family protein
IV89_RS11770	COG0596	Alpha beta hydrolase
IV89_RS11775	COG0662	Cupin 2, conserved barrel domain protein
IV89_RS11780	COG0187	DNA topoisomerase II activity
IV89_RS11810	COG1136	(ABC) transporter
IV89_RS11825	COG0442	prolyl-tRNA aminoacylation
IV89_RS11835	COG0628	permease
IV89_RS11845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IV89_RS11850	COG0248	Ppx GppA phosphatase
IV89_RS11865	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IV89_RS11880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IV89_RS11880	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IV89_RS11895	COG4770	biotin carboxylase activity
IV89_RS11920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IV89_RS11925	COG2814	Major facilitator Superfamily
IV89_RS11930	COG1396	sequence-specific DNA binding
IV89_RS11930	COG3800	Transcriptional regulator
IV89_RS11955	COG3119	arylsulfatase activity
IV89_RS11960	COG1309	transcriptional regulator
IV89_RS11980	COG0217	transcriptional regulatory protein
IV89_RS11985	COG0471	metal ion transport
IV89_RS11985	COG3273	potassium ion transport
IV89_RS11990	COG0471	metal ion transport
IV89_RS11990	COG3273	potassium ion transport
IV89_RS11995	COG1692	metallophosphoesterase
IV89_RS12000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IV89_RS12005	COG2239	Acts as a magnesium transporter
IV89_RS12010	COG0402	S-adenosylhomocysteine deaminase activity
IV89_RS12025	COG0483	inositol monophosphate 1-phosphatase activity
IV89_RS12030	COG1396	sequence-specific DNA binding
IV89_RS12035	COG0670	Belongs to the BI1 family
IV89_RS12045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IV89_RS12065	COG0154	amidase activity
IV89_RS12070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IV89_RS12075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IV89_RS12090	COG0590	tRNA wobble adenosine to inosine editing
IV89_RS12095	COG1187	pseudouridine synthase activity
IV89_RS12140	COG1490	D-aminoacyl-tRNA deacylase activity
IV89_RS12165	COG2936	dipeptidyl-peptidase activity
IV89_RS12180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IV89_RS12185	COG4172	Belongs to the ABC transporter superfamily
IV89_RS12195	COG0657	acetylesterase activity
IV89_RS12200	COG0318	PFAM AMP-dependent synthetase and ligase
IV89_RS12205	COG1652	LysM domain
IV89_RS12210	COG1132	(ABC) transporter
IV89_RS12220	COG0318	PFAM AMP-dependent synthetase and ligase
IV89_RS12230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IV89_RS12230	COG2010	Cytochrome c
IV89_RS12235	COG2080	2 iron, 2 sulfur cluster binding
IV89_RS12240	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IV89_RS12245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IV89_RS12250	COG3485	protocatechuate 3,4-dioxygenase
IV89_RS12255	COG3485	protocatechuate 3,4-dioxygenase
IV89_RS12260	COG3246	L-lysine catabolic process to acetate
IV89_RS12295	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IV89_RS12305	COG2951	lytic endotransglycosylase activity
IV89_RS12320	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IV89_RS12325	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IV89_RS12350	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IV89_RS12380	COG0583	DNA-binding transcription factor activity
IV89_RS12385	COG0589	response to stress
IV89_RS12390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IV89_RS12400	COG3483	tryptophan 2,3-dioxygenase activity
IV89_RS12420	COG0154	amidase activity
IV89_RS12435	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IV89_RS12440	COG3443	Belongs to the bacterial solute-binding protein 9 family
IV89_RS12465	COG0252	asparaginase activity
IV89_RS12470	COG1115	amino acid carrier protein
IV89_RS12475	COG3268	Saccharopine dehydrogenase
IV89_RS12485	COG1448	Aminotransferase
IV89_RS12495	COG1522	sequence-specific DNA binding
IV89_RS12510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IV89_RS12515	COG2011	ABC-type metal ion transport system permease component
IV89_RS12520	COG1464	Belongs to the NlpA lipoprotein family
IV89_RS12530	COG3386	PFAM SMP-30 Gluconolaconase
IV89_RS12535	COG0800	Aldolase
IV89_RS12540	COG3734	2-keto-3-deoxy-galactonokinase
IV89_RS12545	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS12550	COG0129	dihydroxy-acid dehydratase activity
IV89_RS12560	COG0395	ABC-type sugar transport system, permease component
IV89_RS12565	COG1175	transmembrane transport
IV89_RS12595	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IV89_RS12605	COG0431	NADPH-dependent FMN reductase
IV89_RS12615	COG0798	PFAM Bile acid sodium symporter
IV89_RS12640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IV89_RS12675	COG0024	Methionine aminopeptidase
IV89_RS12695	COG0732	type I restriction modification DNA specificity domain
IV89_RS12745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IV89_RS12750	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IV89_RS12755	COG0124	histidyl-tRNA synthetase
IV89_RS12760	COG2900	Belongs to the SlyX family
IV89_RS12775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IV89_RS12785	COG3845	ABC transporter
IV89_RS12790	COG4603	Belongs to the binding-protein-dependent transport system permease family
IV89_RS12795	COG1079	Belongs to the binding-protein-dependent transport system permease family
IV89_RS12815	COG0625	glutathione transferase activity
IV89_RS12830	COG3757	hydrolase, family 25
IV89_RS12845	COG0277	FAD linked oxidase domain protein
IV89_RS12885	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS12890	COG0583	DNA-binding transcription factor activity
IV89_RS12895	COG2080	2 iron, 2 sulfur cluster binding
IV89_RS12900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IV89_RS12905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IV89_RS12935	COG0784	Response regulator, receiver
IV89_RS12935	COG4191	Histidine kinase
IV89_RS12940	COG2202	Pas domain
IV89_RS12940	COG3920	Histidine kinase
IV89_RS12945	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IV89_RS12955	COG1522	sequence-specific DNA binding
IV89_RS12960	COG0006	proline dipeptidase activity
IV89_RS12965	COG3608	succinylglutamate desuccinylase aspartoacylase
IV89_RS12970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IV89_RS12975	COG0318	PFAM AMP-dependent synthetase and ligase
IV89_RS12980	COG1757	Na H antiporter
IV89_RS12985	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IV89_RS12995	COG2943	transferase activity, transferring hexosyl groups
IV89_RS13005	COG0668	transmembrane transport
IV89_RS13010	COG0028	Belongs to the TPP enzyme family
IV89_RS13045	COG0737	Belongs to the 5'-nucleotidase family
IV89_RS13050	COG3258	Cytochrome c
IV89_RS13075	COG0785	Cytochrome C biogenesis protein
IV89_RS13100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IV89_RS13120	COG0318	PFAM AMP-dependent synthetase and ligase
IV89_RS13125	COG1024	Enoyl-CoA hydratase
IV89_RS13135	COG1960	acyl-CoA dehydrogenase activity
IV89_RS13140	COG1960	acyl-CoA dehydrogenase activity
IV89_RS13145	COG1250	3-hydroxyacyl-CoA dehydrogenase
IV89_RS13145	COG1024	Enoyl-CoA hydratase
IV89_RS13175	COG4172	Belongs to the ABC transporter superfamily
IV89_RS13180	COG0747	negative chemotaxis
IV89_RS13185	COG0601	transmembrane transport
IV89_RS13190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IV89_RS13195	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IV89_RS13200	COG0668	transmembrane transport
IV89_RS13215	COG0438	transferase activity, transferring glycosyl groups
IV89_RS13220	COG0588	phosphoglycerate mutase activity
IV89_RS13235	COG0481	GTPase activity
IV89_RS13255	COG5328	Belongs to the UPF0262 family
IV89_RS13260	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IV89_RS13270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IV89_RS13290	COG0778	Nitroreductase
IV89_RS13300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IV89_RS13315	COG4774	siderophore transport
IV89_RS13320	COG3128	pkhd-type hydroxylase
IV89_RS13330	COG0848	biopolymer transport protein
IV89_RS13345	COG2323	membrane
IV89_RS13355	COG2205	protein histidine kinase activity
IV89_RS13355	COG5002	protein histidine kinase activity
IV89_RS13355	COG0784	Response regulator, receiver
IV89_RS13370	COG1172	Belongs to the binding-protein-dependent transport system permease family
IV89_RS13395	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IV89_RS13425	COG2204	response regulator
IV89_RS13435	COG0095	Lipoate-protein ligase
IV89_RS13440	COG0508	dehydrogenase complex catalyzes the overall conversion of
IV89_RS13450	COG0022	dehydrogenase e1 component
IV89_RS13455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IV89_RS13460	COG1024	Enoyl-CoA hydratase
IV89_RS13465	COG0604	alcohol dehydrogenase
IV89_RS13465	COG3321	synthase
IV89_RS13480	COG2388	GCN5-related N-acetyl-transferase
IV89_RS13485	COG0583	DNA-binding transcription factor activity
IV89_RS13495	COG2205	protein histidine kinase activity
IV89_RS13515	COG2828	Protein conserved in bacteria
IV89_RS13530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IV89_RS13540	COG1802	Transcriptional regulator
IV89_RS13545	COG3976	FMN-binding domain protein
IV89_RS13545	COG1053	succinate dehydrogenase
IV89_RS13555	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IV89_RS13560	COG0583	DNA-binding transcription factor activity
IV89_RS13580	COG0702	epimerase
IV89_RS13605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IV89_RS13610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IV89_RS13690	COG0582	viral genome integration into host DNA
IV89_RS13705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IV89_RS13720	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
IV89_RS13740	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IV89_RS13750	COG0424	maF-like protein
IV89_RS13755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IV89_RS13760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IV89_RS13765	COG0583	DNA-binding transcription factor activity
IV89_RS13770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IV89_RS13785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IV89_RS13790	COG1183	phosphatidylcholine synthase activity
IV89_RS13800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IV89_RS13805	COG3768	UPF0283 membrane protein
IV89_RS13815	COG3106	COG3106 Predicted ATPase
IV89_RS13820	COG0101	tRNA pseudouridine synthase activity
IV89_RS13825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IV89_RS13835	COG0306	phosphate transporter
IV89_RS13845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IV89_RS13850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IV89_RS13870	COG0612	Peptidase, M16
IV89_RS13880	COG3346	SURF1 family
IV89_RS13890	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IV89_RS13900	COG0109	protoheme IX farnesyltransferase activity
IV89_RS13910	COG0312	modulator of DNA gyrase
IV89_RS13915	COG0758	DNA mediated transformation
IV89_RS13920	COG1754	DNA topoisomerase type I activity
IV89_RS13920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IV89_RS13935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IV89_RS13940	COG0741	lytic transglycosylase activity
IV89_RS13955	COG4964	Belongs to the GSP D family
IV89_RS14005	COG1201	RNA secondary structure unwinding
IV89_RS14020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IV89_RS14025	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IV89_RS14035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IV89_RS14040	COG0037	tRNA processing
IV89_RS14050	COG2885	chlorophyll binding
IV89_RS14055	COG0823	Involved in the tonB-independent uptake of proteins
IV89_RS14075	COG0824	Thioesterase
IV89_RS14085	COG2255	four-way junction helicase activity
IV89_RS14090	COG0632	four-way junction helicase activity
IV89_RS14125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IV89_RS14140	COG1703	isobutyryl-CoA mutase activity
IV89_RS14145	COG1643	Atp-dependent helicase
IV89_RS14155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IV89_RS14175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IV89_RS14180	COG4221	oxidoreductase activity
IV89_RS14190	COG0012	GTP binding
IV89_RS14200	COG0159	tryptophan synthase activity
IV89_RS14210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IV89_RS14215	COG0193	aminoacyl-tRNA hydrolase activity
IV89_RS14240	COG0133	tryptophan synthase activity
IV89_RS14250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IV89_RS14260	COG1272	protein, Hemolysin III
IV89_RS14290	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IV89_RS14295	COG1214	PFAM Peptidase M22, glycoprotease
IV89_RS14300	COG0456	acetyltransferase
IV89_RS14305	COG1744	ABC transporter substrate-binding protein PnrA-like
IV89_RS14310	COG3845	ABC transporter
IV89_RS14315	COG4603	Belongs to the binding-protein-dependent transport system permease family
IV89_RS14320	COG1079	Belongs to the binding-protein-dependent transport system permease family
IV89_RS14325	COG0730	response to heat
IV89_RS14335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IV89_RS14340	COG0604	alcohol dehydrogenase
IV89_RS14345	COG2937	Belongs to the GPAT DAPAT family
IV89_RS14350	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IV89_RS14350	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IV89_RS14360	COG0813	purine-nucleoside phosphorylase activity
IV89_RS14405	COG0039	L-malate dehydrogenase activity
IV89_RS14435	COG2030	dehydratase
IV89_RS14440	COG0045	succinate-CoA ligase (ADP-forming) activity
IV89_RS14465	COG0508	dehydrogenase complex catalyzes the overall conversion of
IV89_RS14495	COG2884	Cell division ATP-binding protein ftsE
IV89_RS14510	COG0019	diaminopimelate decarboxylase activity
IV89_RS14525	COG0165	Argininosuccinate lyase
IV89_RS14530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IV89_RS14550	COG0800	Aldolase
IV89_RS14555	COG0129	dihydroxy-acid dehydratase activity
IV89_RS14560	COG2971	BadF BadG BcrA BcrD
IV89_RS14565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IV89_RS14595	COG1921	L-seryl-tRNASec selenium transferase activity
IV89_RS14615	COG0556	nucleotide-excision repair
IV89_RS14655	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IV89_RS14665	COG2027	D-alanyl-D-alanine carboxypeptidase
IV89_RS14675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IV89_RS14680	COG1115	amino acid carrier protein
IV89_RS14690	COG0488	(ABC) transporter
IV89_RS14700	COG1278	Cold shock
IV89_RS14705	COG1376	ErfK ybiS ycfS ynhG family protein
IV89_RS14710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IV89_RS14715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IV89_RS14720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IV89_RS14740	COG1309	transcriptional regulator
IV89_RS14750	COG0493	'glutamate synthase
IV89_RS14755	COG1278	Cold shock
IV89_RS14765	COG4181	ATPase activity
IV89_RS14770	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IV89_RS14775	COG0483	inositol monophosphate 1-phosphatase activity
IV89_RS14780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IV89_RS14780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IV89_RS14785	COG0509	glycine decarboxylation via glycine cleavage system
IV89_RS14790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IV89_RS14805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IV89_RS14820	COG3046	protein related to deoxyribodipyrimidine photolyase
IV89_RS14830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IV89_RS14860	COG0768	penicillin binding
IV89_RS14865	COG0772	Belongs to the SEDS family
IV89_RS14870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IV89_RS14875	COG0339	signal peptide processing
IV89_RS14880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IV89_RS14885	COG3454	Phosphonate metabolism
IV89_RS14895	COG4778	phosphonate C-P lyase system protein PhnL
IV89_RS14900	COG4107	phosphonate C-P lyase system protein PhnK
IV89_RS14905	COG3627	carbon phosphorus lyase activity
IV89_RS14910	COG3626	phosphonate metabolism
IV89_RS14915	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IV89_RS14920	COG3624	Phosphonate C-P lyase system protein PhnG
IV89_RS14925	COG2188	Transcriptional regulator
IV89_RS14935	COG3639	organic phosphonate transmembrane transporter activity
IV89_RS14940	COG3639	organic phosphonate transmembrane transporter activity
IV89_RS14945	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IV89_RS14950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IV89_RS14960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IV89_RS14975	COG0606	chelatase, subunit chli
IV89_RS14985	COG0189	ligase activity
IV89_RS14995	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IV89_RS15005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IV89_RS15010	COG0728	peptidoglycan biosynthetic process
IV89_RS15020	COG0180	Tryptophanyl-tRNA synthetase
IV89_RS15030	COG0778	Nitroreductase
IV89_RS15045	COG0346	lactoylglutathione lyase activity
IV89_RS15050	COG0745	RESPONSE REGULATOR receiver
IV89_RS15065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IV89_RS15070	COG0019	diaminopimelate decarboxylase activity
IV89_RS15090	COG2197	response regulator
IV89_RS15110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IV89_RS15115	COG1122	ATPase activity
IV89_RS15125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IV89_RS15135	COG1522	sequence-specific DNA binding
IV89_RS15140	COG0686	Belongs to the AlaDH PNT family
IV89_RS15145	COG1970	mechanosensitive ion channel activity
IV89_RS15155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IV89_RS15155	COG0072	phenylalanine-tRNA ligase activity
IV89_RS15170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IV89_RS15180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IV89_RS15185	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IV89_RS15195	COG0469	pyruvate kinase activity
IV89_RS15210	COG4948	Mandelate Racemase Muconate Lactonizing
IV89_RS15220	COG2301	Belongs to the HpcH HpaI aldolase family
IV89_RS15230	COG0825	malonyl-CoA metabolic process
IV89_RS15260	COG1309	transcriptional regulator
IV89_RS15275	COG1917	Cupin 2, conserved barrel domain protein
IV89_RS15275	COG2207	Transcriptional regulator
IV89_RS15295	COG0829	nickel cation binding
IV89_RS15300	COG0831	urea catabolic process
IV89_RS15310	COG0832	Belongs to the urease beta subunit family
IV89_RS15315	COG0804	urea catabolic process
IV89_RS15320	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IV89_RS15325	COG0830	nickel cation binding
IV89_RS15330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IV89_RS15350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IV89_RS15360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IV89_RS15365	COG0741	lytic transglycosylase activity
IV89_RS15370	COG0697	spore germination
IV89_RS15375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IV89_RS15375	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IV89_RS15390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IV89_RS15395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IV89_RS15400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IV89_RS15415	COG1051	belongs to the nudix hydrolase family
IV89_RS15420	COG0446	pyridine nucleotide-disulphide oxidoreductase
IV89_RS15420	COG1902	pentaerythritol trinitrate reductase activity
IV89_RS15430	COG0583	DNA-binding transcription factor activity
IV89_RS15450	COG1058	Belongs to the CinA family
IV89_RS15450	COG1546	Belongs to the CinA family
IV89_RS15455	COG1489	DNA binding
IV89_RS15460	COG0024	Methionine aminopeptidase
IV89_RS15465	COG1183	phosphatidylcholine synthase activity
IV89_RS15475	COG0742	ribosomal rna small subunit methyltransferase
IV89_RS15485	COG0678	peroxiredoxin activity
IV89_RS15490	COG2154	pterin-4-alpha-carbinolamine dehydratase
IV89_RS15500	COG0584	glycerophosphoryl diester phosphodiesterase
IV89_RS15510	COG2853	Lipoprotein
IV89_RS15515	COG0583	DNA-binding transcription factor activity
IV89_RS15530	COG0347	Belongs to the P(II) protein family
IV89_RS15535	COG0004	ammonium transporteR
IV89_RS15545	COG2897	thiosulfate sulfurtransferase activity
IV89_RS15550	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IV89_RS15595	COG1012	belongs to the aldehyde dehydrogenase family
IV89_RS15600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IV89_RS15615	COG0247	lactate metabolic process
IV89_RS15625	COG0277	FAD linked oxidase domain protein
IV89_RS15630	COG0277	FAD linked oxidase domain protein
IV89_RS15645	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IV89_RS15650	COG0799	negative regulation of ribosome biogenesis
IV89_RS15655	COG3264	Mechanosensitive ion channel
IV89_RS15655	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IV89_RS15665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IV89_RS15670	COG0066	3-isopropylmalate dehydratase activity
IV89_RS15685	COG0473	3-isopropylmalate dehydrogenase activity
IV89_RS15695	COG2194	sulfuric ester hydrolase activity
IV89_RS15705	COG0745	RESPONSE REGULATOR receiver
IV89_RS15710	COG0642	Histidine kinase
IV89_RS15715	COG1132	(ABC) transporter
IV89_RS15720	COG1120	ATPase activity
IV89_RS15725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IV89_RS15730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IV89_RS15735	COG4774	siderophore transport
IV89_RS15745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IV89_RS15745	COG1648	precorrin-2 dehydrogenase activity
IV89_RS15750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IV89_RS15755	COG0243	molybdopterin cofactor binding
IV89_RS15760	COG2146	nitrite reductase [NAD(P)H] activity
IV89_RS15765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IV89_RS15770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IV89_RS15770	COG1116	anion transmembrane transporter activity
IV89_RS15775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IV89_RS15780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IV89_RS15785	COG1116	anion transmembrane transporter activity
IV89_RS15785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IV89_RS15790	COG3707	response regulator
IV89_RS15810	COG1609	Transcriptional regulator
IV89_RS15815	COG3214	Protein conserved in bacteria
IV89_RS15820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IV89_RS15825	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IV89_RS15840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IV89_RS15850	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IV89_RS15860	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IV89_RS15865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IV89_RS15890	COG0625	glutathione transferase activity
IV89_RS15895	COG2808	Putative FMN-binding domain
IV89_RS15905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IV89_RS15910	COG0142	geranyltranstransferase activity
IV89_RS15915	COG1722	exodeoxyribonuclease VII activity
IV89_RS15920	COG0745	RESPONSE REGULATOR receiver
IV89_RS15925	COG1846	Transcriptional regulator
IV89_RS15930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IV89_RS15945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IV89_RS15950	COG4143	(ABC) transporter
IV89_RS15955	COG1178	ABC-type Fe3 transport system permease component
IV89_RS15960	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IV89_RS15975	COG0438	transferase activity, transferring glycosyl groups
IV89_RS15980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IV89_RS15985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IV89_RS15995	COG0697	spore germination
IV89_RS16005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IV89_RS16015	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IV89_RS16025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IV89_RS16045	COG1968	undecaprenyl-diphosphatase activity
IV89_RS16095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IV89_RS16100	COG1473	amidohydrolase
IV89_RS16110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IV89_RS16115	COG0601	transmembrane transport
IV89_RS16120	COG4166	transmembrane transport
IV89_RS16145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IV89_RS16165	COG2186	Transcriptional regulator
IV89_RS16175	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS16195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IV89_RS16195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IV89_RS16200	COG1312	Catalyzes the dehydration of D-mannonate
IV89_RS16205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IV89_RS16225	COG2010	Cytochrome c
IV89_RS16230	COG0348	domain, Protein
IV89_RS16270	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IV89_RS16280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IV89_RS16290	COG0446	pyridine nucleotide-disulphide oxidoreductase
IV89_RS16290	COG1902	pentaerythritol trinitrate reductase activity
IV89_RS16295	COG2814	Major facilitator Superfamily
IV89_RS16320	COG0683	leucine binding
IV89_RS16375	COG0318	PFAM AMP-dependent synthetase and ligase
IV89_RS16380	COG1024	Enoyl-CoA hydratase
IV89_RS16380	COG1250	3-hydroxyacyl-CoA dehydrogenase
IV89_RS16385	COG1024	Enoyl-CoA hydratase
IV89_RS16395	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS16400	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS16415	COG1946	Acyl-CoA thioesterase
IV89_RS16420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IV89_RS16465	COG0588	phosphoglycerate mutase activity
IV89_RS16470	COG0183	Belongs to the thiolase family
IV89_RS16475	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS16485	COG1960	acyl-CoA dehydrogenase activity
IV89_RS16490	COG1960	acyl-CoA dehydrogenase activity
IV89_RS16495	COG1028	Short-chain dehydrogenase reductase Sdr
IV89_RS16495	COG0604	alcohol dehydrogenase
IV89_RS16495	COG3321	synthase
IV89_RS16500	COG2130	NADP-dependent
IV89_RS16525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IV89_RS16535	COG2814	Major facilitator Superfamily
IV89_RS16545	COG2017	converts alpha-aldose to the beta-anomer
IV89_RS16595	COG5002	protein histidine kinase activity
IV89_RS16605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IV89_RS16615	COG1360	Flagellar Motor Protein
IV89_RS16620	COG4957	zinc ion binding
IV89_RS16655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IV89_RS16660	COG1338	Plays a role in the flagellum-specific transport system
IV89_RS16665	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IV89_RS16675	COG1766	The M ring may be actively involved in energy transduction
IV89_RS16700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IV89_RS16710	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IV89_RS16725	COG1677	Flagellar hook-basal body complex protein FliE
IV89_RS16730	COG1558	bacterial-type flagellum-dependent cell motility
IV89_RS16745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IV89_RS16760	COG1706	bacterial-type flagellum-dependent cell motility
IV89_RS16765	COG0745	RESPONSE REGULATOR receiver
IV89_RS16790	COG4786	Flagellar basal body rod
IV89_RS16795	COG4786	Flagellar basal body rod
IV89_RS16805	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IV89_RS16825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IV89_RS16840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IV89_RS16845	COG2084	Dehydrogenase
IV89_RS16850	COG1012	belongs to the aldehyde dehydrogenase family
IV89_RS16865	COG2124	cytochrome p450
IV89_RS16875	COG0028	Belongs to the TPP enzyme family
IV89_RS16880	COG0300	oxidoreductase activity
IV89_RS16885	COG0625	glutathione transferase activity
IV89_RS16905	COG1192	Involved in chromosome partitioning
IV89_RS16920	COG0183	Belongs to the thiolase family
IV89_RS16935	COG5002	protein histidine kinase activity
IV89_RS16940	COG5002	protein histidine kinase activity
IV89_RS16945	COG0745	RESPONSE REGULATOR receiver
IV89_RS16950	COG1595	DNA-templated transcription, initiation
IV89_RS16980	COG1321	iron dependent repressor
IV89_RS16985	COG2132	Multicopper oxidase
IV89_RS17005	COG1376	ErfK ybiS ycfS ynhG family protein
IV89_RS17020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IV89_RS17025	COG1192	Involved in chromosome partitioning
IV89_RS17120	COG1742	UPF0060 membrane protein
IV89_RS17195	COG3505	Type IV secretory pathway VirD4
IV89_RS17215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IV89_RS17220	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IV89_RS17225	COG0535	radical SAM domain protein
IV89_RS17230	COG0535	radical SAM domain protein
IV89_RS17235	COG0784	Response regulator, receiver
IV89_RS17235	COG2198	Histidine kinase
IV89_RS17235	COG2205	protein histidine kinase activity
IV89_RS17325	COG3901	Regulator of nitric oxide reductase transcription
IV89_RS17325	COG0348	domain, Protein
IV89_RS17330	COG1174	glycine betaine transport
IV89_RS17365	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
IV89_RS17370	COG2948	multi-organism process
IV89_RS17390	COG1196	nuclear chromosome segregation
IV89_RS17390	COG0741	lytic transglycosylase activity
IV89_RS17390	COG0739	heme binding
IV89_RS17415	COG0741	lytic transglycosylase activity
IV89_RS17415	COG0739	heme binding
IV89_RS17415	COG1196	nuclear chromosome segregation
IV89_RS17540	COG0785	Cytochrome C biogenesis protein
IV89_RS17565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IV89_RS17570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IV89_RS17585	COG2132	Multicopper oxidase
IV89_RS17600	COG1230	cation diffusion facilitator family transporter
IV89_RS17615	COG0789	Transcriptional regulator
IV89_RS17620	COG1999	signal sequence binding
IV89_RS17630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IV89_RS17630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IV89_RS17640	COG1999	signal sequence binding
IV89_RS17665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IV89_RS17675	COG2366	antibiotic biosynthetic process
IV89_RS17685	COG3034	peptidoglycan biosynthetic process
IV89_RS17720	COG1196	nuclear chromosome segregation
IV89_RS17720	COG0741	lytic transglycosylase activity
IV89_RS17720	COG0739	heme binding
IV89_RS17805	COG0559	Belongs to the binding-protein-dependent transport system permease family
IV89_RS17845	COG3246	L-lysine catabolic process to acetate
IV89_RS17860	COG3135	benzoate transporter
IV89_RS17875	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IV89_RS17960	COG0410	ABC transporter
IV89_RS17965	COG1137	ATPase activity
IV89_RS18070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IV89_RS18110	COG1192	Involved in chromosome partitioning
IV89_RS18120	COG1414	Transcriptional regulator
IV89_RS18145	COG1475	DNA binding
IV89_RS18160	COG3077	Addiction module antitoxin, RelB DinJ family
IV89_RS18230	COG3505	Type IV secretory pathway VirD4
IV89_RS18290	COG0741	lytic transglycosylase activity
IV89_RS18305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IV89_RS18315	COG0019	diaminopimelate decarboxylase activity
IV89_RS18325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IV89_RS18330	COG0318	PFAM AMP-dependent synthetase and ligase
IV89_RS18335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IV89_RS18340	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IV89_RS18350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IV89_RS18355	COG2135	peptidase activity
IV89_RS18390	COG0640	Transcriptional regulator
IV89_RS18395	COG1475	DNA binding
IV89_RS18400	COG1192	Involved in chromosome partitioning
IV89_RS18430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IV89_RS18435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IV89_RS18475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IV89_RS18480	COG1086	Polysaccharide biosynthesis protein
IV89_RS18490	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IV89_RS18500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IV89_RS18500	COG2755	lipolytic protein G-D-S-L family
IV89_RS18505	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IV89_RS18510	COG0438	transferase activity, transferring glycosyl groups
IV89_RS18515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IV89_RS18525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IV89_RS18545	COG4372	Transposase
IV89_RS18570	COG1091	dTDP-4-dehydrorhamnose reductase activity
IV89_RS18580	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IV89_RS18605	COG0438	transferase activity, transferring glycosyl groups