locus-tag	class	description
B5M07_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B5M07_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B5M07_RS00035	COG1404	Belongs to the peptidase S8 family
B5M07_RS00040	COG0464	growth
B5M07_RS00060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B5M07_RS00085	COG0583	DNA-binding transcription factor activity
B5M07_RS00090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5M07_RS00095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5M07_RS00110	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B5M07_RS00145	COG2442	InterPro IPR007367
B5M07_RS00200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B5M07_RS00225	COG0443	Heat shock 70 kDa protein
B5M07_RS00230	COG0484	heat shock protein binding
B5M07_RS00235	COG2003	Belongs to the UPF0758 family
B5M07_RS00250	COG0653	protein targeting
B5M07_RS00255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5M07_RS00260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B5M07_RS00265	COG0494	nUDIX hydrolase
B5M07_RS00280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B5M07_RS00295	COG0779	Required for maturation of 30S ribosomal subunits
B5M07_RS00300	COG4533	DNA binding
B5M07_RS00310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5M07_RS00320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B5M07_RS00360	COG3034	peptidoglycan biosynthetic process
B5M07_RS00365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B5M07_RS00370	COG1132	(ABC) transporter
B5M07_RS00375	COG1132	(ABC) transporter
B5M07_RS00380	COG0617	tRNA 3'-terminal CCA addition
B5M07_RS00385	COG0494	nUDIX hydrolase
B5M07_RS00395	COG0494	nUDIX hydrolase
B5M07_RS00405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B5M07_RS00410	COG0137	argininosuccinate synthase activity
B5M07_RS00425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5M07_RS00430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5M07_RS00435	COG0281	malic enzyme
B5M07_RS00435	COG0280	phosphate acetyltransferase
B5M07_RS00440	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B5M07_RS00445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B5M07_RS00450	COG1420	regulation of RNA biosynthetic process
B5M07_RS00455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B5M07_RS00460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B5M07_RS00465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B5M07_RS00480	COG0357	Ribosomal RNA small subunit methyltransferase G
B5M07_RS00485	COG0445	tRNA wobble uridine modification
B5M07_RS00490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B5M07_RS00495	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B5M07_RS00500	COG1981	membrane
B5M07_RS00505	COG0424	maF-like protein
B5M07_RS00510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B5M07_RS00515	COG0237	dephospho-CoA kinase activity
B5M07_RS00530	COG3436	PFAM IS66 Orf2 family protein
B5M07_RS00535	COG4372	Transposase
B5M07_RS00550	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B5M07_RS00580	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B5M07_RS00585	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B5M07_RS00600	COG1074	ATP-dependent DNA helicase activity
B5M07_RS00605	COG2887	Belongs to the helicase family. UvrD subfamily
B5M07_RS00610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B5M07_RS00615	COG3178	'Phosphotransferase
B5M07_RS00620	COG0802	atpase or kinase
B5M07_RS00635	COG1999	signal sequence binding
B5M07_RS00640	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B5M07_RS00650	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
B5M07_RS00660	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B5M07_RS00685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B5M07_RS00690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B5M07_RS00720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B5M07_RS00725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B5M07_RS00755	COG0174	glutamine synthetase
B5M07_RS00760	COG1012	belongs to the aldehyde dehydrogenase family
B5M07_RS00770	COG3474	cytochrome
B5M07_RS00775	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B5M07_RS00780	COG0408	coproporphyrinogen oxidase activity
B5M07_RS00785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B5M07_RS00790	COG0181	hydroxymethylbilane synthase activity
B5M07_RS00825	COG3191	aminopeptidase activity
B5M07_RS00835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B5M07_RS00840	COG1396	sequence-specific DNA binding
B5M07_RS00860	COG0784	Response regulator, receiver
B5M07_RS00880	COG1295	ribonuclease BN
B5M07_RS00885	COG2116	formate transmembrane transporter activity
B5M07_RS00910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS00920	COG2358	TRAP transporter, solute receptor (TAXI family
B5M07_RS00935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B5M07_RS00945	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5M07_RS00955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5M07_RS00960	COG0693	protein deglycase activity
B5M07_RS00970	COG2995	paraquat-inducible protein a
B5M07_RS00975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B5M07_RS00975	COG3008	intermembrane lipid transfer
B5M07_RS00995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5M07_RS01000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5M07_RS01005	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B5M07_RS01010	COG1137	ATPase activity
B5M07_RS01025	COG0517	IMP dehydrogenase activity
B5M07_RS01025	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B5M07_RS01030	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B5M07_RS01035	COG3327	negative regulation of DNA-templated transcription, initiation
B5M07_RS01040	COG2030	dehydratase
B5M07_RS01040	COG1012	belongs to the aldehyde dehydrogenase family
B5M07_RS01045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B5M07_RS01050	COG2151	metal-sulfur cluster biosynthetic enzyme
B5M07_RS01055	COG3396	Phenylacetate-CoA oxygenase
B5M07_RS01060	COG3460	Phenylacetate-CoA oxygenase
B5M07_RS01065	COG3396	Phenylacetate-CoA oxygenase
B5M07_RS01085	COG0697	spore germination
B5M07_RS01090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B5M07_RS01095	COG4143	(ABC) transporter
B5M07_RS01105	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B5M07_RS01115	COG2808	Putative FMN-binding domain
B5M07_RS01120	COG0625	glutathione transferase activity
B5M07_RS01140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5M07_RS01145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B5M07_RS01155	COG1177	transmembrane transport
B5M07_RS01160	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5M07_RS01190	COG0582	viral genome integration into host DNA
B5M07_RS01215	COG4372	Transposase
B5M07_RS01220	COG3436	PFAM IS66 Orf2 family protein
B5M07_RS01255	COG1968	undecaprenyl-diphosphatase activity
B5M07_RS01285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B5M07_RS01295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B5M07_RS01305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5M07_RS01320	COG0776	regulation of translation
B5M07_RS01325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B5M07_RS01330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B5M07_RS01360	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5M07_RS01375	COG3932	Exopolysaccharide synthesis, ExoD
B5M07_RS01380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B5M07_RS01385	COG0142	geranyltranstransferase activity
B5M07_RS01390	COG1722	exodeoxyribonuclease VII activity
B5M07_RS01395	COG0745	RESPONSE REGULATOR receiver
B5M07_RS01400	COG1846	Transcriptional regulator
B5M07_RS01405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5M07_RS01410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B5M07_RS01430	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B5M07_RS01430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B5M07_RS01440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B5M07_RS01445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5M07_RS01460	COG1609	Transcriptional regulator
B5M07_RS01480	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B5M07_RS01485	COG0602	queuosine metabolic process
B5M07_RS01490	COG0720	synthase
B5M07_RS01495	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B5M07_RS01500	COG4191	Histidine kinase
B5M07_RS01515	COG0473	3-isopropylmalate dehydrogenase activity
B5M07_RS01530	COG0066	3-isopropylmalate dehydratase activity
B5M07_RS01540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B5M07_RS01545	COG3264	Mechanosensitive ion channel
B5M07_RS01545	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B5M07_RS01550	COG0799	negative regulation of ribosome biogenesis
B5M07_RS01555	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B5M07_RS01565	COG0277	FAD linked oxidase domain protein
B5M07_RS01570	COG0277	FAD linked oxidase domain protein
B5M07_RS01580	COG0247	lactate metabolic process
B5M07_RS01590	COG0071	Belongs to the small heat shock protein (HSP20) family
B5M07_RS01600	COG1012	belongs to the aldehyde dehydrogenase family
B5M07_RS01635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B5M07_RS01640	COG2897	thiosulfate sulfurtransferase activity
B5M07_RS01650	COG2205	protein histidine kinase activity
B5M07_RS01650	COG2198	Histidine kinase
B5M07_RS01650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5M07_RS01650	COG0784	Response regulator, receiver
B5M07_RS01655	COG0004	ammonium transporteR
B5M07_RS01670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5M07_RS01690	COG2154	pterin-4-alpha-carbinolamine dehydratase
B5M07_RS01695	COG0668	transmembrane transport
B5M07_RS01700	COG0678	peroxiredoxin activity
B5M07_RS01710	COG0742	ribosomal rna small subunit methyltransferase
B5M07_RS01745	COG0024	Methionine aminopeptidase
B5M07_RS01750	COG1489	DNA binding
B5M07_RS01755	COG1546	Belongs to the CinA family
B5M07_RS01755	COG1058	Belongs to the CinA family
B5M07_RS01785	COG2423	ornithine cyclodeaminase activity
B5M07_RS01795	COG1671	Belongs to the UPF0178 family
B5M07_RS01800	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B5M07_RS01805	COG0679	Auxin Efflux Carrier
B5M07_RS01825	COG2050	protein possibly involved in aromatic compounds catabolism
B5M07_RS01835	COG0791	NLP P60 protein
B5M07_RS01840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5M07_RS01850	COG0288	reversible hydration of carbon dioxide
B5M07_RS01855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B5M07_RS01875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B5M07_RS01895	COG1194	a g-specific adenine glycosylase
B5M07_RS01905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B5M07_RS01915	COG1663	tetraacyldisaccharide 4'-kinase activity
B5M07_RS01935	COG0312	modulator of DNA gyrase
B5M07_RS01980	COG0495	leucyl-tRNA aminoacylation
B5M07_RS01995	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B5M07_RS02010	COG0745	RESPONSE REGULATOR receiver
B5M07_RS02015	COG0708	Exodeoxyribonuclease III
B5M07_RS02025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B5M07_RS02030	COG2835	tetraacyldisaccharide 4'-kinase activity
B5M07_RS02035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5M07_RS02040	COG0154	amidase activity
B5M07_RS02045	COG0436	Aminotransferase
B5M07_RS02050	COG1674	ftsk spoiiie
B5M07_RS02070	COG0405	Gamma-glutamyltransferase
B5M07_RS02090	COG1956	GAF domain-containing protein
B5M07_RS02095	COG0564	pseudouridine synthase activity
B5M07_RS02100	COG0450	alkyl hydroperoxide reductase
B5M07_RS02115	COG1185	polyribonucleotide nucleotidyltransferase activity
B5M07_RS02120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B5M07_RS02135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B5M07_RS02145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B5M07_RS02150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B5M07_RS02180	COG0138	bifunctional purine biosynthesis protein purh
B5M07_RS02185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B5M07_RS02195	COG0612	Peptidase, M16
B5M07_RS02200	COG0612	Peptidase, M16
B5M07_RS02205	COG1012	belongs to the aldehyde dehydrogenase family
B5M07_RS02215	COG0803	Belongs to the bacterial solute-binding protein 9 family
B5M07_RS02220	COG1121	(ABC) transporter
B5M07_RS02225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B5M07_RS02225	COG1321	iron dependent repressor
B5M07_RS02230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B5M07_RS02235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B5M07_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS02280	COG0625	glutathione transferase activity
B5M07_RS02290	COG3383	formate dehydrogenase (NAD+) activity
B5M07_RS02305	COG4191	Histidine kinase
B5M07_RS02325	COG0559	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS02345	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B5M07_RS02350	COG1178	ABC-type Fe3 transport system permease component
B5M07_RS02355	COG1840	ABC-type Fe3 transport system, periplasmic component
B5M07_RS02360	COG0625	glutathione transferase activity
B5M07_RS02365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B5M07_RS02380	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5M07_RS02390	COG0284	orotidine-5'-phosphate decarboxylase activity
B5M07_RS02410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B5M07_RS02680	COG3772	lysozyme
B5M07_RS02710	COG0673	inositol 2-dehydrogenase activity
B5M07_RS02730	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS02735	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS02750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B5M07_RS02775	COG0745	RESPONSE REGULATOR receiver
B5M07_RS02780	COG0346	lactoylglutathione lyase activity
B5M07_RS02795	COG0778	Nitroreductase
B5M07_RS02805	COG2514	catechol 2,3-dioxygenase activity
B5M07_RS02810	COG0180	Tryptophanyl-tRNA synthetase
B5M07_RS02830	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B5M07_RS02840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B5M07_RS02845	COG0792	nuclease activity
B5M07_RS02850	COG0189	ligase activity
B5M07_RS02860	COG0606	chelatase, subunit chli
B5M07_RS02885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B5M07_RS02890	COG0756	dUTP diphosphatase activity
B5M07_RS02895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B5M07_RS02900	COG0339	signal peptide processing
B5M07_RS02905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5M07_RS02910	COG0772	Belongs to the SEDS family
B5M07_RS02915	COG0768	penicillin binding
B5M07_RS02940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5M07_RS02950	COG3046	protein related to deoxyribodipyrimidine photolyase
B5M07_RS02975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5M07_RS02985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5M07_RS02990	COG0509	glycine decarboxylation via glycine cleavage system
B5M07_RS02995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B5M07_RS02995	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B5M07_RS03000	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B5M07_RS03005	COG4181	ATPase activity
B5M07_RS03015	COG1278	Cold shock
B5M07_RS03035	COG1309	transcriptional regulator
B5M07_RS03055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5M07_RS03060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5M07_RS03070	COG1376	ErfK ybiS ycfS ynhG family protein
B5M07_RS03075	COG1278	Cold shock
B5M07_RS03085	COG0488	(ABC) transporter
B5M07_RS03095	COG1115	amino acid carrier protein
B5M07_RS03100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B5M07_RS03120	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B5M07_RS03155	COG0556	nucleotide-excision repair
B5M07_RS03170	COG0154	amidase activity
B5M07_RS03185	COG0747	negative chemotaxis
B5M07_RS03190	COG0601	transmembrane transport
B5M07_RS03195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS03205	COG1473	amidohydrolase
B5M07_RS03215	COG2207	Transcriptional regulator
B5M07_RS03225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B5M07_RS03240	COG0154	amidase activity
B5M07_RS03250	COG0697	spore germination
B5M07_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS03265	COG0604	alcohol dehydrogenase
B5M07_RS03265	COG3321	synthase
B5M07_RS03280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B5M07_RS03285	COG0129	dihydroxy-acid dehydratase activity
B5M07_RS03290	COG0800	Aldolase
B5M07_RS03295	COG1609	Transcriptional regulator
B5M07_RS03330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B5M07_RS03345	COG4221	oxidoreductase activity
B5M07_RS03350	COG0784	Response regulator, receiver
B5M07_RS03350	COG2198	Histidine kinase
B5M07_RS03350	COG5002	protein histidine kinase activity
B5M07_RS03365	COG0784	Response regulator, receiver
B5M07_RS03375	COG2032	superoxide dismutase activity
B5M07_RS03385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B5M07_RS03400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B5M07_RS03405	COG5328	Belongs to the UPF0262 family
B5M07_RS03420	COG0481	GTPase activity
B5M07_RS03430	COG3246	L-lysine catabolic process to acetate
B5M07_RS03435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B5M07_RS03460	COG1024	Enoyl-CoA hydratase
B5M07_RS03460	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5M07_RS03465	COG0183	Belongs to the thiolase family
B5M07_RS03470	COG1960	acyl-CoA dehydrogenase activity
B5M07_RS03475	COG1960	acyl-CoA dehydrogenase activity
B5M07_RS03485	COG1024	Enoyl-CoA hydratase
B5M07_RS03490	COG0318	PFAM AMP-dependent synthetase and ligase
B5M07_RS03520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5M07_RS03580	COG4372	Transposase
B5M07_RS03585	COG3436	PFAM IS66 Orf2 family protein
B5M07_RS03600	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
B5M07_RS03650	COG1024	Enoyl-CoA hydratase
B5M07_RS03735	COG0604	alcohol dehydrogenase
B5M07_RS03750	COG0277	FAD linked oxidase domain protein
B5M07_RS03765	COG3757	hydrolase, family 25
B5M07_RS03790	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS03795	COG4603	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS03800	COG3845	ABC transporter
B5M07_RS03810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B5M07_RS03835	COG0124	histidyl-tRNA synthetase
B5M07_RS03840	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B5M07_RS03845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B5M07_RS03885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5M07_RS03890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B5M07_RS03945	COG1053	succinate dehydrogenase
B5M07_RS03965	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B5M07_RS03975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B5M07_RS03980	COG1335	isochorismatase
B5M07_RS03995	COG0837	glucose binding
B5M07_RS04000	COG3842	ATPase activity
B5M07_RS04005	COG0395	ABC-type sugar transport system, permease component
B5M07_RS04010	COG1175	transmembrane transport
B5M07_RS04030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B5M07_RS04045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B5M07_RS04055	COG2423	ornithine cyclodeaminase activity
B5M07_RS04060	COG0583	DNA-binding transcription factor activity
B5M07_RS04070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5M07_RS04075	COG0747	negative chemotaxis
B5M07_RS04085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS04090	COG0444	Belongs to the ABC transporter superfamily
B5M07_RS04095	COG4608	Belongs to the ABC transporter superfamily
B5M07_RS04100	COG0402	S-adenosylhomocysteine deaminase activity
B5M07_RS04115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B5M07_RS04135	COG0583	DNA-binding transcription factor activity
B5M07_RS04140	COG2351	hydroxyisourate hydrolase activity
B5M07_RS04150	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
B5M07_RS04170	COG2423	ornithine cyclodeaminase activity
B5M07_RS04175	COG3616	Alanine racemase, N-terminal domain
B5M07_RS04180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B5M07_RS04190	COG1414	Transcriptional regulator
B5M07_RS04195	COG3257	ureidoglycine aminohydrolase activity
B5M07_RS04235	COG2132	Multicopper oxidase
B5M07_RS04280	COG1937	Protein conserved in bacteria
B5M07_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS04295	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B5M07_RS04300	COG0747	negative chemotaxis
B5M07_RS04305	COG0601	transmembrane transport
B5M07_RS04310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS04330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5M07_RS04335	COG0028	Belongs to the TPP enzyme family
B5M07_RS04345	COG1802	Transcriptional regulator
B5M07_RS04350	COG0747	negative chemotaxis
B5M07_RS04355	COG0601	transmembrane transport
B5M07_RS04360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS04370	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS04405	COG0745	RESPONSE REGULATOR receiver
B5M07_RS04415	COG0745	RESPONSE REGULATOR receiver
B5M07_RS04425	COG0583	DNA-binding transcription factor activity
B5M07_RS04430	COG3321	synthase
B5M07_RS04430	COG0604	alcohol dehydrogenase
B5M07_RS04465	COG1732	Glycine betaine
B5M07_RS04470	COG1174	glycine betaine transport
B5M07_RS04475	COG1125	glycine betaine transport
B5M07_RS04480	COG1174	glycine betaine transport
B5M07_RS04490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5M07_RS04495	COG0174	glutamine synthetase
B5M07_RS04500	COG1802	Transcriptional regulator
B5M07_RS04530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B5M07_RS04545	COG1360	Flagellar Motor Protein
B5M07_RS04570	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B5M07_RS04580	COG4786	Flagellar basal body rod
B5M07_RS04585	COG4786	Flagellar basal body rod
B5M07_RS04610	COG1706	bacterial-type flagellum-dependent cell motility
B5M07_RS04625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B5M07_RS04630	COG5442	Flagellar protein FlaF
B5M07_RS04645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B5M07_RS04650	COG1338	Plays a role in the flagellum-specific transport system
B5M07_RS04655	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B5M07_RS04665	COG1766	The M ring may be actively involved in energy transduction
B5M07_RS04690	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B5M07_RS04720	COG1987	bacterial-type flagellum assembly
B5M07_RS04725	COG1677	Flagellar hook-basal body complex protein FliE
B5M07_RS04730	COG1558	bacterial-type flagellum-dependent cell motility
B5M07_RS04745	COG2951	lytic endotransglycosylase activity
B5M07_RS04760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5M07_RS04760	COG3453	Protein conserved in bacteria
B5M07_RS04775	COG0640	Transcriptional regulator
B5M07_RS04790	COG0811	peptide transport
B5M07_RS04810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5M07_RS04820	COG3845	ABC transporter
B5M07_RS04825	COG4603	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS04830	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS04835	COG0402	S-adenosylhomocysteine deaminase activity
B5M07_RS04855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5M07_RS04860	COG0165	Argininosuccinate lyase
B5M07_RS04875	COG0019	diaminopimelate decarboxylase activity
B5M07_RS04890	COG2884	Cell division ATP-binding protein ftsE
B5M07_RS04925	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5M07_RS04955	COG0045	succinate-CoA ligase (ADP-forming) activity
B5M07_RS04960	COG2030	dehydratase
B5M07_RS04975	COG2301	Belongs to the HpcH HpaI aldolase family
B5M07_RS04990	COG0039	L-malate dehydrogenase activity
B5M07_RS05030	COG0813	purine-nucleoside phosphorylase activity
B5M07_RS05040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B5M07_RS05040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B5M07_RS05045	COG2937	Belongs to the GPAT DAPAT family
B5M07_RS05050	COG0604	alcohol dehydrogenase
B5M07_RS05075	COG0730	response to heat
B5M07_RS05080	COG1079	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS05085	COG4603	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS05090	COG3845	ABC transporter
B5M07_RS05095	COG1744	ABC transporter substrate-binding protein PnrA-like
B5M07_RS05105	COG1214	PFAM Peptidase M22, glycoprotease
B5M07_RS05110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B5M07_RS05150	COG0583	DNA-binding transcription factor activity
B5M07_RS05160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5M07_RS05170	COG0133	tryptophan synthase activity
B5M07_RS05205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B5M07_RS05210	COG0193	aminoacyl-tRNA hydrolase activity
B5M07_RS05215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B5M07_RS05225	COG1304	FMN binding
B5M07_RS05230	COG0159	tryptophan synthase activity
B5M07_RS05240	COG0012	GTP binding
B5M07_RS05325	COG4948	Mandelate Racemase Muconate Lactonizing
B5M07_RS05330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B5M07_RS05345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B5M07_RS05350	COG3842	ATPase activity
B5M07_RS05355	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5M07_RS05360	COG1177	transmembrane transport
B5M07_RS05380	COG0784	Response regulator, receiver
B5M07_RS05380	COG4191	Histidine kinase
B5M07_RS05385	COG3454	Phosphonate metabolism
B5M07_RS05400	COG4778	phosphonate C-P lyase system protein PhnL
B5M07_RS05405	COG4107	phosphonate C-P lyase system protein PhnK
B5M07_RS05410	COG3627	carbon phosphorus lyase activity
B5M07_RS05415	COG3626	phosphonate metabolism
B5M07_RS05420	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
B5M07_RS05425	COG3624	Phosphonate C-P lyase system protein PhnG
B5M07_RS05430	COG2188	Transcriptional regulator
B5M07_RS05435	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5M07_RS05440	COG3639	organic phosphonate transmembrane transporter activity
B5M07_RS05445	COG3639	organic phosphonate transmembrane transporter activity
B5M07_RS05450	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B5M07_RS05455	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B5M07_RS05480	COG1238	metal cluster binding
B5M07_RS05485	COG3773	Cell wall hydrolase
B5M07_RS05495	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B5M07_RS05505	COG2986	histidine ammonia-lyase
B5M07_RS05510	COG1228	amidohydrolase
B5M07_RS05525	COG0837	glucose binding
B5M07_RS05545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5M07_RS05565	COG1047	Peptidyl-prolyl cis-trans
B5M07_RS05575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B5M07_RS05580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5M07_RS05585	COG1012	belongs to the aldehyde dehydrogenase family
B5M07_RS05590	COG0702	epimerase
B5M07_RS05595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5M07_RS05610	COG1183	phosphatidylcholine synthase activity
B5M07_RS05625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5M07_RS05645	COG1702	phosphate starvation-inducible protein PhoH
B5M07_RS05650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B5M07_RS05655	COG1253	flavin adenine dinucleotide binding
B5M07_RS05660	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B5M07_RS05665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B5M07_RS05670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B5M07_RS05680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B5M07_RS05685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B5M07_RS05690	COG0745	RESPONSE REGULATOR receiver
B5M07_RS05695	COG0539	negative regulation of cytoplasmic translation
B5M07_RS05700	COG0776	regulation of translation
B5M07_RS05710	COG0135	phosphoribosylanthranilate isomerase activity
B5M07_RS05715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5M07_RS05720	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B5M07_RS05770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B5M07_RS05780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B5M07_RS05785	COG0306	phosphate transporter
B5M07_RS05795	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B5M07_RS05800	COG0101	tRNA pseudouridine synthase activity
B5M07_RS05805	COG3106	COG3106 Predicted ATPase
B5M07_RS05815	COG3768	UPF0283 membrane protein
B5M07_RS05825	COG0438	transferase activity, transferring glycosyl groups
B5M07_RS05840	COG0438	transferase activity, transferring glycosyl groups
B5M07_RS05850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B5M07_RS05855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B5M07_RS05860	COG1183	phosphatidylcholine synthase activity
B5M07_RS05865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B5M07_RS05870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B5M07_RS05875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B5M07_RS05885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B5M07_RS05890	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B5M07_RS05895	COG0424	maF-like protein
B5M07_RS05900	COG1530	ribonuclease E activity
B5M07_RS05905	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B5M07_RS06020	COG1946	Acyl-CoA thioesterase
B5M07_RS06025	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS06035	COG1832	CoA-binding protein
B5M07_RS06040	COG0140	phosphoribosyl-ATP diphosphatase activity
B5M07_RS06045	COG0107	imidazoleglycerol-phosphate synthase activity
B5M07_RS06050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B5M07_RS06065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B5M07_RS06070	COG0131	Imidazoleglycerol-phosphate dehydratase
B5M07_RS06085	COG0745	RESPONSE REGULATOR receiver
B5M07_RS06100	COG1522	sequence-specific DNA binding
B5M07_RS06110	COG1492	cobalamin metabolic process
B5M07_RS06125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B5M07_RS06130	COG0354	folic acid binding
B5M07_RS06140	COG1132	(ABC) transporter
B5M07_RS06145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B5M07_RS06150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B5M07_RS06160	COG0525	valine-tRNA ligase activity
B5M07_RS06195	COG1473	amidohydrolase
B5M07_RS06205	COG1522	sequence-specific DNA binding
B5M07_RS06225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5M07_RS06235	COG0667	Aldo Keto reductase
B5M07_RS06300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B5M07_RS06305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5M07_RS06315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5M07_RS06315	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5M07_RS06330	COG0358	DNA primase activity
B5M07_RS06335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5M07_RS06350	COG0432	Pfam Uncharacterised protein family UPF0047
B5M07_RS06355	COG4221	oxidoreductase activity
B5M07_RS06360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B5M07_RS06365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5M07_RS06365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5M07_RS06385	COG1484	DNA-dependent DNA replication
B5M07_RS06390	COG4584	PFAM Integrase catalytic
B5M07_RS06410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B5M07_RS06415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5M07_RS06470	COG0583	DNA-binding transcription factor activity
B5M07_RS06475	COG2130	NADP-dependent
B5M07_RS06480	COG0483	inositol monophosphate 1-phosphatase activity
B5M07_RS06490	COG0564	pseudouridine synthase activity
B5M07_RS06500	COG2186	Transcriptional regulator
B5M07_RS06515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B5M07_RS06530	COG1793	dna ligase
B5M07_RS06530	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B5M07_RS06540	COG2267	carboxylic ester hydrolase activity
B5M07_RS06565	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B5M07_RS06570	COG1329	Transcriptional regulator
B5M07_RS06575	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B5M07_RS06580	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B5M07_RS06610	COG2873	o-acetylhomoserine
B5M07_RS06625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5M07_RS06650	COG0321	lipoyl(octanoyl) transferase activity
B5M07_RS06665	COG0729	surface antigen
B5M07_RS06690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5M07_RS06710	COG0628	permease
B5M07_RS06780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5M07_RS06785	COG2205	protein histidine kinase activity
B5M07_RS06800	COG0463	Glycosyl transferase, family 2
B5M07_RS06820	COG0586	Pfam SNARE associated Golgi protein
B5M07_RS06830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5M07_RS06835	COG2814	Major facilitator Superfamily
B5M07_RS06840	COG0730	response to heat
B5M07_RS06855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B5M07_RS06860	COG4235	cytochrome complex assembly
B5M07_RS06865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5M07_RS06880	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5M07_RS06880	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5M07_RS06905	COG2962	Rard protein
B5M07_RS06920	COG5265	(ABC) transporter
B5M07_RS06940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5M07_RS06945	COG1160	GTP binding
B5M07_RS06955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B5M07_RS06960	COG1862	Preprotein translocase
B5M07_RS06965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5M07_RS06970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5M07_RS06980	COG3737	Protein of unknown function (DUF498/DUF598)
B5M07_RS06985	COG4133	protoheme IX ABC transporter activity
B5M07_RS06990	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5M07_RS06995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5M07_RS07005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5M07_RS07010	COG0655	NAD(P)H dehydrogenase (quinone) activity
B5M07_RS07035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B5M07_RS07055	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B5M07_RS07060	COG1295	ribonuclease BN
B5M07_RS07105	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B5M07_RS07105	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B5M07_RS07115	COG0544	peptidyl-prolyl cis-trans isomerase activity
B5M07_RS07125	COG1234	tRNA 3'-trailer cleavage
B5M07_RS07130	COG0084	hydrolase, TatD family'
B5M07_RS07140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B5M07_RS07145	COG1686	Belongs to the peptidase S11 family
B5M07_RS07160	COG0582	viral genome integration into host DNA
B5M07_RS07175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5M07_RS07185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5M07_RS07190	COG1116	anion transmembrane transporter activity
B5M07_RS07195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B5M07_RS07200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5M07_RS07205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B5M07_RS07215	COG2022	thiamine diphosphate biosynthetic process
B5M07_RS07230	COG0351	phosphomethylpyrimidine kinase
B5M07_RS07235	COG0587	DNA-directed DNA polymerase activity
B5M07_RS07255	COG1573	uracil-dna glycosylase
B5M07_RS07265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B5M07_RS07280	COG0318	PFAM AMP-dependent synthetase and ligase
B5M07_RS07285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B5M07_RS07285	COG2111	Na H antiporter
B5M07_RS07290	COG1006	Multisubunit Na H antiporter MnhC subunit
B5M07_RS07295	COG0651	ATP synthesis coupled electron transport
B5M07_RS07300	COG1863	multisubunit Na H antiporter MnhE subunit
B5M07_RS07305	COG2212	antiporter activity
B5M07_RS07310	COG1320	monovalent cation:proton antiporter activity
B5M07_RS07330	COG3448	diguanylate cyclase activity
B5M07_RS07330	COG4175	Glycine betaine
B5M07_RS07350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B5M07_RS07375	COG1846	Transcriptional regulator
B5M07_RS07390	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS07405	COG1960	acyl-CoA dehydrogenase activity
B5M07_RS07415	COG3483	tryptophan 2,3-dioxygenase activity
B5M07_RS07440	COG1129	ABC transporter
B5M07_RS07450	COG0251	oxidation-reduction process
B5M07_RS07455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B5M07_RS07460	COG1121	(ABC) transporter
B5M07_RS07480	COG2391	methyltransferase activity
B5M07_RS07495	COG0785	Cytochrome C biogenesis protein
B5M07_RS07520	COG3258	Cytochrome c
B5M07_RS07525	COG0737	Belongs to the 5'-nucleotidase family
B5M07_RS07530	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B5M07_RS07540	COG0740	serine-type endopeptidase activity
B5M07_RS07545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B5M07_RS07570	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B5M07_RS07575	COG0439	Biotin carboxylase
B5M07_RS07585	COG0410	ABC transporter
B5M07_RS07610	COG1396	sequence-specific DNA binding
B5M07_RS07610	COG3800	Transcriptional regulator
B5M07_RS07640	COG3750	Belongs to the UPF0335 family
B5M07_RS07650	COG0544	peptidyl-prolyl cis-trans isomerase activity
B5M07_RS07655	COG0737	Belongs to the 5'-nucleotidase family
B5M07_RS07660	COG0741	lytic transglycosylase activity
B5M07_RS07660	COG0739	heme binding
B5M07_RS07660	COG1196	nuclear chromosome segregation
B5M07_RS07670	COG0359	binds to the 23S rRNA
B5M07_RS07675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B5M07_RS07680	COG0360	Binds together with S18 to 16S ribosomal RNA
B5M07_RS07685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B5M07_RS07705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5M07_RS07715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5M07_RS07720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B5M07_RS07735	COG4695	Portal protein
B5M07_RS07815	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5M07_RS07820	COG0022	dehydrogenase e1 component
B5M07_RS07820	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5M07_RS07825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B5M07_RS07830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B5M07_RS07835	COG0126	phosphoglycerate kinase activity
B5M07_RS07860	COG0739	heme binding
B5M07_RS07865	COG2833	Protein of unknown function (DUF455)
B5M07_RS07870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5M07_RS07880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B5M07_RS07885	COG2814	Major facilitator Superfamily
B5M07_RS07895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5M07_RS07910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B5M07_RS07930	COG1960	acyl-CoA dehydrogenase activity
B5M07_RS07935	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B5M07_RS07955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B5M07_RS07965	COG2354	Protein conserved in bacteria
B5M07_RS07970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B5M07_RS07990	COG0698	ribose 5-phosphate isomerase
B5M07_RS07995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B5M07_RS08010	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B5M07_RS08035	COG2885	chlorophyll binding
B5M07_RS08040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B5M07_RS08050	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B5M07_RS08070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5M07_RS08090	COG0305	Participates in initiation and elongation during chromosome replication
B5M07_RS08095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B5M07_RS08100	COG0418	dihydroorotase activity
B5M07_RS08145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B5M07_RS08165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B5M07_RS08170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B5M07_RS08175	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B5M07_RS08190	COG1138	Cytochrome C-type biogenesis protein
B5M07_RS08195	COG3088	subunit of a heme lyase
B5M07_RS08200	COG1024	Enoyl-CoA hydratase
B5M07_RS08210	COG0372	Belongs to the citrate synthase family
B5M07_RS08215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5M07_RS08220	COG2333	competence protein COMEC
B5M07_RS08220	COG0658	competence protein
B5M07_RS08225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5M07_RS08230	COG0303	'Molybdopterin
B5M07_RS08235	COG0315	cyclic pyranopterin monophosphate synthase activity
B5M07_RS08245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B5M07_RS08250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B5M07_RS08270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5M07_RS08285	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B5M07_RS08290	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B5M07_RS08295	COG0259	pyridoxamine-phosphate oxidase activity
B5M07_RS08315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5M07_RS08345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5M07_RS08365	COG4774	siderophore transport
B5M07_RS08370	COG3128	pkhd-type hydroxylase
B5M07_RS08380	COG0848	biopolymer transport protein
B5M07_RS08405	COG1802	Transcriptional regulator
B5M07_RS08425	COG2828	Protein conserved in bacteria
B5M07_RS08465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5M07_RS08475	COG0215	cysteine-tRNA ligase activity
B5M07_RS08480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5M07_RS08495	COG2814	Major facilitator Superfamily
B5M07_RS08500	COG2099	Precorrin-6x reductase
B5M07_RS08540	COG0316	Belongs to the HesB IscA family
B5M07_RS08545	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B5M07_RS08555	COG0018	arginyl-trna synthetase
B5M07_RS08565	COG1472	Belongs to the glycosyl hydrolase 3 family
B5M07_RS08570	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B5M07_RS08575	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B5M07_RS08580	COG0717	Belongs to the dCTP deaminase family
B5M07_RS08595	COG0776	regulation of translation
B5M07_RS08600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5M07_RS08605	COG0416	fatty acid biosynthetic process
B5M07_RS08610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B5M07_RS08630	COG0488	(ABC) transporter
B5M07_RS08645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B5M07_RS08650	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B5M07_RS08655	COG0456	acetyltransferase
B5M07_RS08660	COG0148	phosphopyruvate hydratase activity
B5M07_RS08665	COG0697	spore germination
B5M07_RS08685	COG0513	Belongs to the DEAD box helicase family
B5M07_RS08695	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B5M07_RS08710	COG3956	TIGRFAM MazG family protein
B5M07_RS08720	COG0010	Belongs to the arginase family
B5M07_RS08735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B5M07_RS08740	COG2890	protein-(glutamine-N5) methyltransferase activity
B5M07_RS08755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B5M07_RS08760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B5M07_RS08770	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B5M07_RS08785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5M07_RS08800	COG3577	Aspartyl protease
B5M07_RS08805	COG2095	MarC family integral membrane protein
B5M07_RS08810	COG0488	(ABC) transporter
B5M07_RS08815	COG0105	UTP biosynthetic process
B5M07_RS08845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B5M07_RS08850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B5M07_RS08855	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B5M07_RS08865	COG2166	iron-sulfur cluster assembly
B5M07_RS08875	COG5012	cobalamin binding
B5M07_RS08885	COG1410	methionine synthase
B5M07_RS08885	COG0646	methionine synthase
B5M07_RS08895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B5M07_RS08900	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B5M07_RS08905	COG0047	phosphoribosylformylglycinamidine synthase activity
B5M07_RS08915	COG2204	response regulator
B5M07_RS08925	COG1530	ribonuclease E activity
B5M07_RS08930	COG0425	Belongs to the sulfur carrier protein TusA family
B5M07_RS08935	COG0785	Cytochrome C biogenesis protein
B5M07_RS08950	COG3588	fructose-bisphosphate aldolase
B5M07_RS08970	COG0114	fumarate hydratase activity
B5M07_RS08980	COG2059	Chromate
B5M07_RS08990	COG2186	Transcriptional regulator
B5M07_RS09010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5M07_RS09015	COG0604	alcohol dehydrogenase
B5M07_RS09025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B5M07_RS09030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B5M07_RS09035	COG0415	Belongs to the DNA photolyase family
B5M07_RS09040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B5M07_RS09050	COG0494	nUDIX hydrolase
B5M07_RS09060	COG3264	Mechanosensitive ion channel
B5M07_RS09060	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B5M07_RS09080	COG1376	ErfK ybiS ycfS ynhG family protein
B5M07_RS09100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5M07_RS09120	COG0433	COG0433 Predicted ATPase
B5M07_RS09130	COG0559	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS09150	COG2133	pyrroloquinoline quinone binding
B5M07_RS09160	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B5M07_RS09170	COG1561	YicC-like family, N-terminal region
B5M07_RS09175	COG0194	GDP metabolic process
B5M07_RS09185	COG5002	protein histidine kinase activity
B5M07_RS09195	COG0573	inorganic phosphate transmembrane transporter activity
B5M07_RS09205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5M07_RS09215	COG0745	RESPONSE REGULATOR receiver
B5M07_RS09220	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B5M07_RS09225	COG2197	response regulator
B5M07_RS09230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B5M07_RS09235	COG0052	Belongs to the universal ribosomal protein uS2 family
B5M07_RS09260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B5M07_RS09265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B5M07_RS09270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B5M07_RS09280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B5M07_RS09285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B5M07_RS09285	COG3743	rRNA binding
B5M07_RS09315	COG0784	Response regulator, receiver
B5M07_RS09315	COG4191	Histidine kinase
B5M07_RS09325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5M07_RS09345	COG0348	domain, Protein
B5M07_RS09350	COG2010	Cytochrome c
B5M07_RS09375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5M07_RS09385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5M07_RS09390	COG1116	anion transmembrane transporter activity
B5M07_RS09400	COG1464	Belongs to the NlpA lipoprotein family
B5M07_RS09405	COG2011	ABC-type metal ion transport system permease component
B5M07_RS09410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B5M07_RS09430	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B5M07_RS09435	COG0248	Ppx GppA phosphatase
B5M07_RS09445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B5M07_RS09460	COG0604	alcohol dehydrogenase
B5M07_RS09490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5M07_RS09495	COG4215	(ABC) transporter
B5M07_RS09510	COG3246	L-lysine catabolic process to acetate
B5M07_RS09515	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5M07_RS09515	COG0824	Thioesterase
B5M07_RS09520	COG1960	acyl-CoA dehydrogenase activity
B5M07_RS09540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B5M07_RS09555	COG0719	Fe-S assembly protein
B5M07_RS09560	COG0396	ATPase activity
B5M07_RS09570	COG0719	Fe-S assembly protein
B5M07_RS09580	COG1959	2 iron, 2 sulfur cluster binding
B5M07_RS09585	COG2945	thiolester hydrolase activity
B5M07_RS09600	COG0538	isocitrate dehydrogenase activity
B5M07_RS09615	COG2076	Multidrug Resistance protein
B5M07_RS09620	COG1217	gtp-binding protein TYPA
B5M07_RS09625	COG0671	phosphoesterase, PA-phosphatase related
B5M07_RS09635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B5M07_RS09640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B5M07_RS09655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B5M07_RS09655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5M07_RS09680	COG2202	Pas domain
B5M07_RS09680	COG2205	protein histidine kinase activity
B5M07_RS09685	COG0318	PFAM AMP-dependent synthetase and ligase
B5M07_RS09690	COG0166	Belongs to the GPI family
B5M07_RS09700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B5M07_RS09710	COG5425	PFAM Usg family protein
B5M07_RS09715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B5M07_RS09720	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B5M07_RS09725	COG1612	heme a metabolic process
B5M07_RS09755	COG2313	pseudouridylate synthase activity
B5M07_RS09770	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS09775	COG4166	transmembrane transport
B5M07_RS09795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B5M07_RS09815	COG2084	Dehydrogenase
B5M07_RS09825	COG1187	pseudouridine synthase activity
B5M07_RS09835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B5M07_RS09840	COG1923	regulation of RNA biosynthetic process
B5M07_RS09845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5M07_RS09850	COG0569	domain protein
B5M07_RS09860	COG2204	response regulator
B5M07_RS09865	COG5000	phosphorelay sensor kinase activity
B5M07_RS09870	COG2204	response regulator
B5M07_RS09875	COG3852	Histidine kinase
B5M07_RS09880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5M07_RS09885	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B5M07_RS09885	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B5M07_RS09890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B5M07_RS09900	COG2867	negative regulation of translational initiation
B5M07_RS09905	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B5M07_RS09915	COG2010	Cytochrome c
B5M07_RS09920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B5M07_RS09930	COG0583	DNA-binding transcription factor activity
B5M07_RS09935	COG0753	catalase activity
B5M07_RS09985	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B5M07_RS09990	COG0596	Alpha beta hydrolase
B5M07_RS09995	COG2326	polyphosphate kinase activity
B5M07_RS10000	COG1309	transcriptional regulator
B5M07_RS10005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5M07_RS10015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B5M07_RS10020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B5M07_RS10025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5M07_RS10040	COG1024	Enoyl-CoA hydratase
B5M07_RS10045	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B5M07_RS10050	COG2226	methyltransferase
B5M07_RS10055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5M07_RS10060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B5M07_RS10075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B5M07_RS10080	COG0745	RESPONSE REGULATOR receiver
B5M07_RS10090	COG0482	sulfurtransferase activity
B5M07_RS10095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5M07_RS10100	COG3494	Protein of unknown function (DUF1009)
B5M07_RS10105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5M07_RS10110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5M07_RS10120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5M07_RS10125	COG0750	zinc metalloprotease
B5M07_RS10130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B5M07_RS10140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B5M07_RS10145	COG0233	cytoplasmic translational termination
B5M07_RS10150	COG0528	UMP kinase activity
B5M07_RS10155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B5M07_RS10165	COG0601	transmembrane transport
B5M07_RS10170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS10185	COG0741	lytic transglycosylase activity
B5M07_RS10190	COG0629	single-stranded DNA binding
B5M07_RS10195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B5M07_RS10200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B5M07_RS10210	COG4974	Belongs to the 'phage' integrase family
B5M07_RS10220	COG4536	flavin adenine dinucleotide binding
B5M07_RS10250	COG4176	ABC-type proline glycine betaine transport system permease component
B5M07_RS10255	COG0517	IMP dehydrogenase activity
B5M07_RS10255	COG4175	Glycine betaine
B5M07_RS10260	COG1366	Belongs to the anti-sigma-factor antagonist family
B5M07_RS10265	COG1366	Belongs to the anti-sigma-factor antagonist family
B5M07_RS10290	COG0431	NADPH-dependent FMN reductase
B5M07_RS10295	COG0798	PFAM Bile acid sodium symporter
B5M07_RS10325	COG4681	YaeQ
B5M07_RS10335	COG2855	membrane
B5M07_RS10340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B5M07_RS10355	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B5M07_RS10360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5M07_RS10370	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS10375	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B5M07_RS10395	COG1609	Transcriptional regulator
B5M07_RS10400	COG2267	carboxylic ester hydrolase activity
B5M07_RS10430	COG0395	ABC-type sugar transport system, permease component
B5M07_RS10435	COG1175	transmembrane transport
B5M07_RS10445	COG3842	ATPase activity
B5M07_RS10465	COG1238	metal cluster binding
B5M07_RS10475	COG0010	Belongs to the arginase family
B5M07_RS10485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5M07_RS10495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5M07_RS10515	COG1764	response to oxidative stress
B5M07_RS10540	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B5M07_RS10560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B5M07_RS10565	COG0028	Belongs to the TPP enzyme family
B5M07_RS10585	COG0154	amidase activity
B5M07_RS10590	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B5M07_RS10595	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B5M07_RS10600	COG0860	N-Acetylmuramoyl-L-alanine amidase
B5M07_RS10605	COG0436	Aminotransferase
B5M07_RS10620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B5M07_RS10630	COG0156	8-amino-7-oxononanoate synthase activity
B5M07_RS10660	COG0406	alpha-ribazole phosphatase activity
B5M07_RS10665	COG0406	alpha-ribazole phosphatase activity
B5M07_RS10675	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B5M07_RS10680	COG1902	pentaerythritol trinitrate reductase activity
B5M07_RS10685	COG0343	queuine tRNA-ribosyltransferase activity
B5M07_RS10705	COG4067	protein conserved in archaea
B5M07_RS10705	COG0189	ligase activity
B5M07_RS10710	COG2151	metal-sulfur cluster biosynthetic enzyme
B5M07_RS10735	COG0149	triose-phosphate isomerase activity
B5M07_RS10740	COG1522	sequence-specific DNA binding
B5M07_RS10745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5M07_RS10745	COG1648	precorrin-2 dehydrogenase activity
B5M07_RS10755	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5M07_RS10760	COG0175	sulfate reduction
B5M07_RS10780	COG0300	oxidoreductase activity
B5M07_RS10785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B5M07_RS10790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B5M07_RS10795	COG1388	LysM domain
B5M07_RS10795	COG0739	heme binding
B5M07_RS10805	COG0805	protein transport
B5M07_RS10810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5M07_RS10815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5M07_RS10820	COG2378	regulation of single-species biofilm formation
B5M07_RS10845	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS10860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B5M07_RS10870	COG0513	Belongs to the DEAD box helicase family
B5M07_RS10885	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B5M07_RS10895	COG1007	ATP synthesis coupled electron transport
B5M07_RS10910	COG0713	ATP synthesis coupled electron transport
B5M07_RS10925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5M07_RS10930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B5M07_RS10965	COG3743	rRNA binding
B5M07_RS10965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B5M07_RS10975	COG0649	NAD binding
B5M07_RS10980	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5M07_RS10985	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5M07_RS10995	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B5M07_RS11015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B5M07_RS11020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5M07_RS11040	COG1960	acyl-CoA dehydrogenase activity
B5M07_RS11050	COG0546	phosphoglycolate phosphatase activity
B5M07_RS11055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5M07_RS11075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B5M07_RS11080	COG1519	Transferase
B5M07_RS11090	COG1473	amidohydrolase
B5M07_RS11095	COG1473	amidohydrolase
B5M07_RS11100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5M07_RS11105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5M07_RS11110	COG4172	Belongs to the ABC transporter superfamily
B5M07_RS11120	COG0601	transmembrane transport
B5M07_RS11125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS11140	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B5M07_RS11155	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS11165	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B5M07_RS11170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B5M07_RS11180	COG0308	aminopeptidase N
B5M07_RS11200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5M07_RS11220	COG0484	heat shock protein binding
B5M07_RS11240	COG0006	proline dipeptidase activity
B5M07_RS11255	COG0497	DNA recombination
B5M07_RS11260	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5M07_RS11270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B5M07_RS11280	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B5M07_RS11285	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5M07_RS11290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B5M07_RS11310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5M07_RS11315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B5M07_RS11330	COG2081	HI0933 family
B5M07_RS11335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B5M07_RS11345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5M07_RS11355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B5M07_RS11370	COG0275	rRNA processing
B5M07_RS11375	COG2001	Belongs to the MraZ family
B5M07_RS11385	COG0489	protein tyrosine kinase activity
B5M07_RS11395	COG0210	DNA helicase
B5M07_RS11410	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B5M07_RS11425	COG1610	YqeY-like protein
B5M07_RS11430	COG0505	Belongs to the CarA family
B5M07_RS11440	COG1802	Transcriptional regulator
B5M07_RS11470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B5M07_RS11480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5M07_RS11485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B5M07_RS11490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B5M07_RS11500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B5M07_RS11500	COG0574	Belongs to the PEP-utilizing enzyme family
B5M07_RS11505	COG0751	glycine-tRNA ligase activity
B5M07_RS11520	COG0752	glycyl-tRNA synthetase alpha subunit
B5M07_RS11525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5M07_RS11530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5M07_RS11540	COG1469	GTP cyclohydrolase I activity
B5M07_RS11560	COG1285	pathogenesis
B5M07_RS11565	COG0552	protein localization to endoplasmic reticulum
B5M07_RS11570	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B5M07_RS11575	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5M07_RS11590	COG0151	Belongs to the GarS family
B5M07_RS11620	COG0330	HflC and HflK could
B5M07_RS11635	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B5M07_RS11645	COG1760	l-serine dehydratase
B5M07_RS11650	COG1741	Belongs to the pirin family
B5M07_RS11675	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B5M07_RS11715	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5M07_RS11725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B5M07_RS11735	COG0713	ATP synthesis coupled electron transport
B5M07_RS11745	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5M07_RS11750	COG1007	ATP synthesis coupled electron transport
B5M07_RS11785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5M07_RS11790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5M07_RS11795	COG2010	Cytochrome c
B5M07_RS11815	COG1230	cation diffusion facilitator family transporter
B5M07_RS11830	COG1937	Protein conserved in bacteria
B5M07_RS11920	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B5M07_RS11925	COG2205	protein histidine kinase activity
B5M07_RS11930	COG0745	RESPONSE REGULATOR receiver
B5M07_RS11965	COG0489	protein tyrosine kinase activity
B5M07_RS11965	COG3206	protein involved in exopolysaccharide biosynthesis
B5M07_RS11980	COG0438	transferase activity, transferring glycosyl groups
B5M07_RS12000	COG2977	Belongs to the P-Pant transferase superfamily
B5M07_RS12005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B5M07_RS12075	COG0697	spore germination
B5M07_RS12095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B5M07_RS12120	COG0504	CTP synthase activity
B5M07_RS12125	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B5M07_RS12155	COG4215	(ABC) transporter
B5M07_RS12160	COG4160	amino acid transport
B5M07_RS12165	COG0174	glutamine synthetase
B5M07_RS12170	COG0519	Catalyzes the synthesis of GMP from XMP
B5M07_RS12175	COG0174	glutamine synthetase
B5M07_RS12180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5M07_RS12185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B5M07_RS12200	COG3243	poly(R)-hydroxyalkanoic acid synthase
B5M07_RS12225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B5M07_RS12235	COG3220	belongs to the UPF0276 family
B5M07_RS12250	COG1393	Belongs to the ArsC family
B5M07_RS12255	COG1278	Cold shock
B5M07_RS12265	COG2124	cytochrome p450
B5M07_RS12275	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B5M07_RS12290	COG1846	Transcriptional regulator
B5M07_RS12315	COG0534	Mate efflux family protein
B5M07_RS12320	COG2267	carboxylic ester hydrolase activity
B5M07_RS12335	COG0187	DNA topoisomerase II activity
B5M07_RS12355	COG1136	(ABC) transporter
B5M07_RS12370	COG0442	prolyl-tRNA aminoacylation
B5M07_RS12375	COG0628	permease
B5M07_RS12385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B5M07_RS12390	COG0248	Ppx GppA phosphatase
B5M07_RS12405	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B5M07_RS12415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B5M07_RS12415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B5M07_RS12425	COG4770	biotin carboxylase activity
B5M07_RS12450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B5M07_RS12455	COG2814	Major facilitator Superfamily
B5M07_RS12460	COG3800	Transcriptional regulator
B5M07_RS12460	COG1396	sequence-specific DNA binding
B5M07_RS12480	COG1309	transcriptional regulator
B5M07_RS12500	COG0217	transcriptional regulatory protein
B5M07_RS12505	COG0471	metal ion transport
B5M07_RS12505	COG3273	potassium ion transport
B5M07_RS12525	COG0471	metal ion transport
B5M07_RS12525	COG3273	potassium ion transport
B5M07_RS12530	COG1692	metallophosphoesterase
B5M07_RS12535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B5M07_RS12540	COG2239	Acts as a magnesium transporter
B5M07_RS12545	COG0402	S-adenosylhomocysteine deaminase activity
B5M07_RS12560	COG0483	inositol monophosphate 1-phosphatase activity
B5M07_RS12565	COG1396	sequence-specific DNA binding
B5M07_RS12570	COG0670	Belongs to the BI1 family
B5M07_RS12580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B5M07_RS12585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5M07_RS12590	COG0154	amidase activity
B5M07_RS12600	COG3023	N-Acetylmuramoyl-L-alanine amidase
B5M07_RS12610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B5M07_RS12625	COG0590	tRNA wobble adenosine to inosine editing
B5M07_RS12645	COG3853	Toxic anion resistance protein (TelA)
B5M07_RS12670	COG1490	D-aminoacyl-tRNA deacylase activity
B5M07_RS12685	COG0318	PFAM AMP-dependent synthetase and ligase
B5M07_RS12690	COG1132	(ABC) transporter
B5M07_RS12710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B5M07_RS12710	COG2010	Cytochrome c
B5M07_RS12730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B5M07_RS12745	COG2010	Cytochrome c
B5M07_RS12775	COG2010	Cytochrome c
B5M07_RS12775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B5M07_RS12780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B5M07_RS12790	COG0583	DNA-binding transcription factor activity
B5M07_RS12830	COG1012	belongs to the aldehyde dehydrogenase family
B5M07_RS12845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5M07_RS12870	COG3842	ATPase activity
B5M07_RS12875	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5M07_RS12880	COG1177	transmembrane transport
B5M07_RS12890	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B5M07_RS12895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5M07_RS12900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B5M07_RS12925	COG0725	ABC transporter, periplasmic molybdate-binding protein
B5M07_RS12930	COG4149	molybdate abc transporter
B5M07_RS12935	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B5M07_RS12955	COG0659	secondary active sulfate transmembrane transporter activity
B5M07_RS12960	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B5M07_RS12965	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B5M07_RS12990	COG3346	SURF1 family
B5M07_RS13000	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B5M07_RS13010	COG0109	protoheme IX farnesyltransferase activity
B5M07_RS13020	COG0312	modulator of DNA gyrase
B5M07_RS13025	COG0758	DNA mediated transformation
B5M07_RS13030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B5M07_RS13030	COG1754	DNA topoisomerase type I activity
B5M07_RS13045	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B5M07_RS13065	COG4964	Belongs to the GSP D family
B5M07_RS13115	COG1201	RNA secondary structure unwinding
B5M07_RS13130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B5M07_RS13135	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B5M07_RS13150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5M07_RS13155	COG0037	tRNA processing
B5M07_RS13165	COG2885	chlorophyll binding
B5M07_RS13170	COG0823	Involved in the tonB-independent uptake of proteins
B5M07_RS13190	COG0824	Thioesterase
B5M07_RS13200	COG2255	four-way junction helicase activity
B5M07_RS13205	COG0632	four-way junction helicase activity
B5M07_RS13240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B5M07_RS13265	COG1703	isobutyryl-CoA mutase activity
B5M07_RS13270	COG1643	Atp-dependent helicase
B5M07_RS13280	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B5M07_RS13305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5M07_RS13310	COG4948	Mandelate Racemase Muconate Lactonizing
B5M07_RS13315	COG0022	dehydrogenase e1 component
B5M07_RS13320	COG1960	acyl-CoA dehydrogenase activity
B5M07_RS13325	COG0583	DNA-binding transcription factor activity
B5M07_RS13340	COG0737	Belongs to the 5'-nucleotidase family
B5M07_RS13360	COG0534	Mate efflux family protein
B5M07_RS13385	COG2197	response regulator
B5M07_RS13390	COG0789	Transcriptional regulator
B5M07_RS13395	COG1960	acyl-CoA dehydrogenase activity
B5M07_RS13405	COG1960	acyl-CoA dehydrogenase activity
B5M07_RS13410	COG0625	glutathione transferase activity
B5M07_RS13415	COG0183	Belongs to the thiolase family
B5M07_RS13420	COG1024	Enoyl-CoA hydratase
B5M07_RS13420	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5M07_RS13435	COG0318	PFAM AMP-dependent synthetase and ligase
B5M07_RS13450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B5M07_RS13455	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B5M07_RS13460	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B5M07_RS13465	COG0295	cytidine deaminase activity
B5M07_RS13470	COG0281	malic enzyme
B5M07_RS13470	COG0280	phosphate acetyltransferase
B5M07_RS13490	COG0019	diaminopimelate decarboxylase activity
B5M07_RS13500	COG3237	CsbD-like
B5M07_RS13505	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B5M07_RS13510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B5M07_RS13525	COG0596	Alpha beta hydrolase
B5M07_RS13530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B5M07_RS13555	COG1435	thymidine kinase activity
B5M07_RS13565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5M07_RS13585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B5M07_RS13605	COG1522	sequence-specific DNA binding
B5M07_RS13610	COG0492	ferredoxin-NADP+ reductase activity
B5M07_RS13615	COG2046	Belongs to the sulfate adenylyltransferase family
B5M07_RS13615	COG0529	Catalyzes the synthesis of activated sulfate
B5M07_RS13620	COG0384	phenazine biosynthesis protein PhzF
B5M07_RS13630	COG0071	Belongs to the small heat shock protein (HSP20) family
B5M07_RS13640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B5M07_RS13645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B5M07_RS13650	COG3454	Phosphonate metabolism
B5M07_RS13670	COG4251	negative regulation of phosphorylation
B5M07_RS13680	COG4251	negative regulation of phosphorylation
B5M07_RS13685	COG2201	protein-glutamate methylesterase activity
B5M07_RS13690	COG0459	protein refolding
B5M07_RS13695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B5M07_RS13710	COG1227	inorganic diphosphatase activity
B5M07_RS13720	COG2030	dehydratase
B5M07_RS13725	COG0196	riboflavin kinase activity
B5M07_RS13730	COG2983	Belongs to the UPF0260 family
B5M07_RS13740	COG2267	carboxylic ester hydrolase activity
B5M07_RS13760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B5M07_RS13765	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B5M07_RS13770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B5M07_RS13775	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B5M07_RS13780	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B5M07_RS13790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5M07_RS13815	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B5M07_RS13830	COG0287	Prephenate dehydrogenase
B5M07_RS13835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B5M07_RS13840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B5M07_RS13845	COG2818	Glycosylase
B5M07_RS13870	COG2890	protein-(glutamine-N5) methyltransferase activity
B5M07_RS13880	COG0142	geranyltranstransferase activity
B5M07_RS13885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B5M07_RS13900	COG0789	Transcriptional regulator
B5M07_RS13910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5M07_RS13920	COG0303	'Molybdopterin
B5M07_RS13925	COG0746	molybdenum cofactor guanylyltransferase activity
B5M07_RS13930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B5M07_RS13965	COG1960	acyl-CoA dehydrogenase activity
B5M07_RS13970	COG0009	L-threonylcarbamoyladenylate synthase
B5M07_RS13975	COG1678	Uncharacterized ACR, COG1678
B5M07_RS13985	COG0521	Mo-molybdopterin cofactor biosynthetic process
B5M07_RS13990	COG1280	lysine exporter protein (LysE YggA)
B5M07_RS13995	COG1573	uracil-dna glycosylase
B5M07_RS14000	COG0540	Belongs to the ATCase OTCase family
B5M07_RS14010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B5M07_RS14015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B5M07_RS14035	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B5M07_RS14055	COG0314	molybdopterin synthase activity
B5M07_RS14065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B5M07_RS14070	COG0322	excinuclease ABC activity
B5M07_RS14090	COG0842	Transport permease protein
B5M07_RS14095	COG1131	(ABC) transporter
B5M07_RS14105	COG0697	spore germination
B5M07_RS14110	COG3321	synthase
B5M07_RS14110	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS14110	COG0604	alcohol dehydrogenase
B5M07_RS14120	COG1294	oxidase, subunit
B5M07_RS14125	COG1271	oxidase subunit
B5M07_RS14130	COG2205	protein histidine kinase activity
B5M07_RS14145	COG4566	intracellular signal transduction
B5M07_RS14150	COG4191	Histidine kinase
B5M07_RS14150	COG2205	protein histidine kinase activity
B5M07_RS14150	COG0745	RESPONSE REGULATOR receiver
B5M07_RS14155	COG2197	response regulator
B5M07_RS14160	COG0596	Alpha beta hydrolase
B5M07_RS14165	COG2202	Pas domain
B5M07_RS14165	COG2205	protein histidine kinase activity
B5M07_RS14175	COG5002	protein histidine kinase activity
B5M07_RS14180	COG0583	DNA-binding transcription factor activity
B5M07_RS14185	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS14210	COG4774	siderophore transport
B5M07_RS14215	COG1120	ATPase activity
B5M07_RS14220	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5M07_RS14225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5M07_RS14230	COG4607	ABC-type enterochelin transport system periplasmic component
B5M07_RS14235	COG2198	Histidine kinase
B5M07_RS14235	COG5002	protein histidine kinase activity
B5M07_RS14235	COG0784	Response regulator, receiver
B5M07_RS14245	COG2197	response regulator
B5M07_RS14290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5M07_RS14300	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B5M07_RS14305	COG0594	ribonuclease P activity
B5M07_RS14310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B5M07_RS14315	COG0037	tRNA processing
B5M07_RS14320	COG5001	Diguanylate cyclase
B5M07_RS14325	COG0706	membrane insertase activity
B5M07_RS14335	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B5M07_RS14340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B5M07_RS14350	COG1126	abc transporter atp-binding protein
B5M07_RS14355	COG0765	amino acid transport
B5M07_RS14360	COG4597	amino acid ABC transporter
B5M07_RS14365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5M07_RS14375	COG0546	phosphoglycolate phosphatase activity
B5M07_RS14380	COG0564	pseudouridine synthase activity
B5M07_RS14385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B5M07_RS14415	COG0785	Cytochrome C biogenesis protein
B5M07_RS14430	COG1999	signal sequence binding
B5M07_RS14445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5M07_RS14450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5M07_RS14475	COG1230	cation diffusion facilitator family transporter
B5M07_RS14480	COG0517	IMP dehydrogenase activity
B5M07_RS14505	COG1999	signal sequence binding
B5M07_RS14525	COG1999	signal sequence binding
B5M07_RS14545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B5M07_RS14550	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B5M07_RS14590	COG1321	iron dependent repressor
B5M07_RS14615	COG3034	peptidoglycan biosynthetic process
B5M07_RS14640	COG1230	cation diffusion facilitator family transporter
B5M07_RS14650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B5M07_RS14655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5M07_RS14690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5M07_RS14695	COG0203	ribosomal protein L17
B5M07_RS14700	COG0202	RNA polymerase activity
B5M07_RS14705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B5M07_RS14710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B5M07_RS14715	COG0563	adenylate kinase activity
B5M07_RS14720	COG0201	protein transport
B5M07_RS14725	COG0200	Binds to the 23S rRNA
B5M07_RS14735	COG1841	ribosomal large subunit assembly
B5M07_RS14740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B5M07_RS14745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B5M07_RS14750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B5M07_RS14755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B5M07_RS14760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B5M07_RS14765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B5M07_RS14770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B5M07_RS14775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B5M07_RS14780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B5M07_RS14785	COG0255	Belongs to the universal ribosomal protein uL29 family
B5M07_RS14810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B5M07_RS14815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B5M07_RS14820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B5M07_RS14825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B5M07_RS14830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B5M07_RS14840	COG3239	Fatty acid desaturase
B5M07_RS14850	COG0089	rRNA binding
B5M07_RS14855	COG0088	Forms part of the polypeptide exit tunnel
B5M07_RS14860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B5M07_RS14865	COG0051	transcription antitermination factor activity, RNA binding
B5M07_RS14870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5M07_RS14875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5M07_RS14880	COG0049	tRNA binding
B5M07_RS14885	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B5M07_RS14900	COG0745	RESPONSE REGULATOR receiver
B5M07_RS14905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B5M07_RS14910	COG0085	RNA polymerase activity
B5M07_RS14915	COG0222	ribosome binding
B5M07_RS14920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B5M07_RS14925	COG0081	regulation of translation
B5M07_RS14930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B5M07_RS14935	COG0250	Participates in transcription elongation, termination and antitermination
B5M07_RS14995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5M07_RS15005	COG2124	cytochrome p450
B5M07_RS15010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B5M07_RS15020	COG0300	oxidoreductase activity
B5M07_RS15030	COG2096	Adenosyltransferase
B5M07_RS15050	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5M07_RS15060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5M07_RS15070	COG1660	Displays ATPase and GTPase activities
B5M07_RS15080	COG2205	protein histidine kinase activity
B5M07_RS15085	COG0745	RESPONSE REGULATOR receiver
B5M07_RS15090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B5M07_RS15095	COG0583	DNA-binding transcription factor activity
B5M07_RS15115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B5M07_RS15125	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B5M07_RS15130	COG0356	it plays a direct role in the translocation of protons across the membrane
B5M07_RS15155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B5M07_RS15160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B5M07_RS15170	COG0228	four-way junction DNA binding
B5M07_RS15175	COG0778	Nitroreductase
B5M07_RS15180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B5M07_RS15190	COG0336	Belongs to the RNA methyltransferase TrmD family
B5M07_RS15200	COG0335	large ribosomal subunit rRNA binding
B5M07_RS15205	COG0254	rRNA binding
B5M07_RS15215	COG0489	protein tyrosine kinase activity
B5M07_RS15215	COG2151	metal-sulfur cluster biosynthetic enzyme
B5M07_RS15230	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B5M07_RS15235	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5M07_RS15260	COG0747	negative chemotaxis
B5M07_RS15270	COG0673	inositol 2-dehydrogenase activity
B5M07_RS15295	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B5M07_RS15300	COG1011	Hydrolase
B5M07_RS15305	COG1686	Belongs to the peptidase S11 family
B5M07_RS15310	COG4172	Belongs to the ABC transporter superfamily
B5M07_RS15315	COG4239	(ABC) transporter, permease
B5M07_RS15320	COG4174	ABC transporter (Permease)
B5M07_RS15330	COG2205	protein histidine kinase activity
B5M07_RS15335	COG2267	carboxylic ester hydrolase activity
B5M07_RS15345	COG0077	Prephenate dehydratase
B5M07_RS15345	COG1605	Chorismate mutase
B5M07_RS15355	COG2816	NAD+ diphosphatase activity
B5M07_RS15360	COG0737	Belongs to the 5'-nucleotidase family
B5M07_RS15370	COG2321	neutral zinc metallopeptidase
B5M07_RS15380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B5M07_RS15385	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B5M07_RS15390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B5M07_RS15415	COG3321	synthase
B5M07_RS15415	COG0604	alcohol dehydrogenase
B5M07_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS15420	COG0318	PFAM AMP-dependent synthetase and ligase
B5M07_RS15425	COG0183	Belongs to the thiolase family
B5M07_RS15430	COG1268	BioY protein
B5M07_RS15435	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B5M07_RS15440	COG1122	ATPase activity
B5M07_RS15450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B5M07_RS15455	COG1522	sequence-specific DNA binding
B5M07_RS15460	COG0686	Belongs to the AlaDH PNT family
B5M07_RS15465	COG1970	mechanosensitive ion channel activity
B5M07_RS15480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5M07_RS15480	COG0072	phenylalanine-tRNA ligase activity
B5M07_RS15490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B5M07_RS15515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B5M07_RS15520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B5M07_RS15530	COG0469	pyruvate kinase activity
B5M07_RS15555	COG4948	Mandelate Racemase Muconate Lactonizing
B5M07_RS15565	COG2301	Belongs to the HpcH HpaI aldolase family
B5M07_RS15570	COG0825	malonyl-CoA metabolic process
B5M07_RS15595	COG0512	Glutamine amidotransferase of anthranilate synthase
B5M07_RS15595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5M07_RS15630	COG1381	Involved in DNA repair and RecF pathway recombination
B5M07_RS15640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B5M07_RS15645	COG0571	ribonuclease III activity
B5M07_RS15650	COG0681	Belongs to the peptidase S26 family
B5M07_RS15655	COG0736	holo-[acyl-carrier-protein] synthase activity
B5M07_RS15665	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B5M07_RS15675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B5M07_RS15680	COG1758	RNA polymerase activity
B5M07_RS15685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B5M07_RS15695	COG2197	response regulator
B5M07_RS15700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B5M07_RS15705	COG0328	RNA-DNA hybrid ribonuclease activity
B5M07_RS15710	COG2860	membrane
B5M07_RS15715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B5M07_RS15720	COG0242	peptide deformylase activity
B5M07_RS15730	COG0242	peptide deformylase activity
B5M07_RS15735	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B5M07_RS15745	COG0435	Glutathione S-transferase
B5M07_RS15755	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B5M07_RS15770	COG0251	oxidation-reduction process
B5M07_RS15775	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B5M07_RS15780	COG0709	Synthesizes selenophosphate from selenide and ATP
B5M07_RS15785	COG0513	Belongs to the DEAD box helicase family
B5M07_RS15790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5M07_RS15805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B5M07_RS15815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5M07_RS15820	COG0028	Belongs to the TPP enzyme family
B5M07_RS15825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B5M07_RS15830	COG0243	molybdopterin cofactor binding
B5M07_RS15835	COG0437	4 iron, 4 sulfur cluster binding
B5M07_RS15845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5M07_RS15850	COG0741	lytic transglycosylase activity
B5M07_RS15860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5M07_RS15860	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B5M07_RS15870	COG2885	chlorophyll binding
B5M07_RS15875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B5M07_RS15880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B5M07_RS15885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5M07_RS15900	COG1051	belongs to the nudix hydrolase family
B5M07_RS15910	COG1902	pentaerythritol trinitrate reductase activity
B5M07_RS15910	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5M07_RS15920	COG0583	DNA-binding transcription factor activity
B5M07_RS15925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B5M07_RS15935	COG0285	dihydrofolate synthase activity
B5M07_RS15940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B5M07_RS15950	COG0129	dihydroxy-acid dehydratase activity
B5M07_RS15970	COG0793	Belongs to the peptidase S41A family
B5M07_RS15980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B5M07_RS15990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5M07_RS15990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5M07_RS16005	COG3622	Belongs to the hyi family
B5M07_RS16015	COG0714	Associated with various cellular activities
B5M07_RS16045	COG3022	response to hydroperoxide
B5M07_RS16050	COG0514	ATP-dependent DNA helicase (RecQ)
B5M07_RS16065	COG2270	Major facilitator Superfamily
B5M07_RS16105	COG1797	cobyrinic acid a,c-diamide synthase activity
B5M07_RS16110	COG2875	Belongs to the precorrin methyltransferase family
B5M07_RS16125	COG2099	Precorrin-6x reductase
B5M07_RS16180	COG3920	Histidine kinase
B5M07_RS16185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B5M07_RS16190	COG1335	isochorismatase
B5M07_RS16195	COG1054	Belongs to the UPF0176 family
B5M07_RS16200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5M07_RS16205	COG1177	transmembrane transport
B5M07_RS16210	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5M07_RS16215	COG3842	ATPase activity
B5M07_RS16225	COG1802	Transcriptional regulator
B5M07_RS16235	COG2951	lytic endotransglycosylase activity
B5M07_RS16240	COG0557	exoribonuclease II activity
B5M07_RS16250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5M07_RS16265	COG2171	N-acyltransferase activity
B5M07_RS16275	COG2070	2-Nitropropane dioxygenase
B5M07_RS16285	COG0784	Response regulator, receiver
B5M07_RS16285	COG2198	Histidine kinase
B5M07_RS16285	COG2205	protein histidine kinase activity
B5M07_RS16295	COG2204	response regulator
B5M07_RS16305	COG0745	RESPONSE REGULATOR receiver
B5M07_RS16310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5M07_RS16315	COG1012	belongs to the aldehyde dehydrogenase family
B5M07_RS16320	COG1522	sequence-specific DNA binding
B5M07_RS16325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5M07_RS16330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B5M07_RS16335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B5M07_RS16340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B5M07_RS16345	COG0589	response to stress
B5M07_RS16355	COG0006	proline dipeptidase activity
B5M07_RS16360	COG3608	succinylglutamate desuccinylase aspartoacylase
B5M07_RS16365	COG4608	Belongs to the ABC transporter superfamily
B5M07_RS16370	COG0444	Belongs to the ABC transporter superfamily
B5M07_RS16375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS16380	COG0601	transmembrane transport
B5M07_RS16385	COG0006	proline dipeptidase activity
B5M07_RS16390	COG0747	negative chemotaxis
B5M07_RS16405	COG4172	Belongs to the ABC transporter superfamily
B5M07_RS16410	COG0444	Belongs to the ABC transporter superfamily
B5M07_RS16415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS16425	COG0747	negative chemotaxis
B5M07_RS16435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B5M07_RS16445	COG0456	acetyltransferase
B5M07_RS16450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B5M07_RS16455	COG1917	Cupin 2, conserved barrel domain protein
B5M07_RS16460	COG0527	aspartate kinase activity
B5M07_RS16475	COG0560	Phosphoserine phosphatase
B5M07_RS16480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B5M07_RS16485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5M07_RS16490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B5M07_RS16495	COG1063	alcohol dehydrogenase
B5M07_RS16500	COG0156	8-amino-7-oxononanoate synthase activity
B5M07_RS16505	COG1396	sequence-specific DNA binding
B5M07_RS16510	COG0183	Belongs to the thiolase family
B5M07_RS16520	COG2226	methyltransferase
B5M07_RS16525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B5M07_RS16530	COG1024	Enoyl-CoA hydratase
B5M07_RS16535	COG0268	Binds directly to 16S ribosomal RNA
B5M07_RS16540	COG1192	Involved in chromosome partitioning
B5M07_RS16545	COG1475	DNA binding
B5M07_RS16555	COG3852	Histidine kinase
B5M07_RS16560	COG1363	Peptidase, m42
B5M07_RS16600	COG1021	2,3-dihydroxybenzoate-AMP ligase
B5M07_RS16610	COG4221	oxidoreductase activity
B5M07_RS16615	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B5M07_RS16620	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS16625	COG2084	Dehydrogenase
B5M07_RS16630	COG1012	belongs to the aldehyde dehydrogenase family
B5M07_RS16645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B5M07_RS16650	COG2188	Transcriptional regulator
B5M07_RS16655	COG0730	response to heat
B5M07_RS16665	COG0405	Gamma-glutamyltransferase
B5M07_RS16670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS16675	COG0601	transmembrane transport
B5M07_RS16680	COG0747	negative chemotaxis
B5M07_RS16685	COG4608	Belongs to the ABC transporter superfamily
B5M07_RS16700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5M07_RS16705	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B5M07_RS16725	COG1280	lysine exporter protein (LysE YggA)
B5M07_RS16745	COG3932	Exopolysaccharide synthesis, ExoD
B5M07_RS16750	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
B5M07_RS16755	COG1349	DNA-binding transcription factor activity
B5M07_RS16765	COG3842	ATPase activity
B5M07_RS16780	COG0395	ABC-type sugar transport system, permease component
B5M07_RS16795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B5M07_RS16800	COG1454	alcohol dehydrogenase
B5M07_RS16810	COG0405	Gamma-glutamyltransferase
B5M07_RS16815	COG4608	Belongs to the ABC transporter superfamily
B5M07_RS16820	COG0444	Belongs to the ABC transporter superfamily
B5M07_RS16825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS16830	COG0601	transmembrane transport
B5M07_RS16835	COG0747	negative chemotaxis
B5M07_RS16840	COG1414	Transcriptional regulator
B5M07_RS16845	COG0753	catalase activity
B5M07_RS16860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B5M07_RS16870	COG0625	glutathione transferase activity
B5M07_RS16875	COG1546	Belongs to the CinA family
B5M07_RS16875	COG1058	Belongs to the CinA family
B5M07_RS16895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5M07_RS16900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5M07_RS16910	COG2943	transferase activity, transferring hexosyl groups
B5M07_RS16915	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B5M07_RS16920	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B5M07_RS16930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5M07_RS16935	COG0765	amino acid transport
B5M07_RS16950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5M07_RS16955	COG3938	Belongs to the proline racemase family
B5M07_RS16965	COG3938	Belongs to the proline racemase family
B5M07_RS16970	COG4166	transmembrane transport
B5M07_RS16975	COG0601	transmembrane transport
B5M07_RS16980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5M07_RS17010	COG0673	inositol 2-dehydrogenase activity
B5M07_RS17015	COG1129	ABC transporter
B5M07_RS17020	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS17025	COG1879	ABC-type sugar transport system periplasmic component
B5M07_RS17030	COG1070	Carbohydrate kinase
B5M07_RS17035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B5M07_RS17040	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B5M07_RS17045	COG2080	2 iron, 2 sulfur cluster binding
B5M07_RS17050	COG0754	glutathionylspermidine amidase activity
B5M07_RS17055	COG5463	Belongs to the UPF0441 family
B5M07_RS17065	COG3246	L-lysine catabolic process to acetate
B5M07_RS17070	COG1024	Enoyl-CoA hydratase
B5M07_RS17070	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5M07_RS17075	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS17080	COG0583	DNA-binding transcription factor activity
B5M07_RS17085	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
B5M07_RS17095	COG2721	sulfolactate sulfo-lyase activity
B5M07_RS17105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5M07_RS17110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5M07_RS17130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5M07_RS17145	COG1691	(AIR) carboxylase
B5M07_RS17155	COG2186	Transcriptional regulator
B5M07_RS17160	COG2358	TRAP transporter, solute receptor (TAXI family
B5M07_RS17165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B5M07_RS17165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B5M07_RS17170	COG0028	Belongs to the TPP enzyme family
B5M07_RS17175	COG0277	FAD linked oxidase domain protein
B5M07_RS17180	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS17185	COG1309	transcriptional regulator
B5M07_RS17195	COG0829	nickel cation binding
B5M07_RS17200	COG0831	urea catabolic process
B5M07_RS17210	COG0832	Belongs to the urease beta subunit family
B5M07_RS17215	COG0804	urea catabolic process
B5M07_RS17220	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B5M07_RS17225	COG0830	nickel cation binding
B5M07_RS17230	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B5M07_RS17245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B5M07_RS17260	COG1522	sequence-specific DNA binding
B5M07_RS17270	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B5M07_RS17290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B5M07_RS17310	COG1192	Involved in chromosome partitioning
B5M07_RS17320	COG1126	abc transporter atp-binding protein
B5M07_RS17335	COG2204	response regulator
B5M07_RS17345	COG0437	4 iron, 4 sulfur cluster binding
B5M07_RS17350	COG3383	formate dehydrogenase (NAD+) activity
B5M07_RS17350	COG0243	molybdopterin cofactor binding
B5M07_RS17385	COG0489	protein tyrosine kinase activity
B5M07_RS17415	COG1192	Involved in chromosome partitioning
B5M07_RS17455	COG1475	DNA binding
B5M07_RS17470	COG3077	Addiction module antitoxin, RelB DinJ family
B5M07_RS17520	COG0346	lactoylglutathione lyase activity
B5M07_RS17605	COG2948	multi-organism process
B5M07_RS17625	COG0739	heme binding
B5M07_RS17625	COG1196	nuclear chromosome segregation
B5M07_RS17625	COG0741	lytic transglycosylase activity
B5M07_RS17645	COG1196	nuclear chromosome segregation
B5M07_RS17645	COG0741	lytic transglycosylase activity
B5M07_RS17645	COG0739	heme binding
B5M07_RS17680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B5M07_RS17685	COG2226	methyltransferase
B5M07_RS17695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5M07_RS17700	COG1120	ATPase activity
B5M07_RS17720	COG1285	pathogenesis
B5M07_RS17725	COG3932	Exopolysaccharide synthesis, ExoD
B5M07_RS17750	COG4372	Transposase
B5M07_RS17765	COG2826	transposase and inactivated derivatives, IS30 family
B5M07_RS17790	COG1022	Amp-dependent synthetase and ligase
B5M07_RS17810	COG0559	Belongs to the binding-protein-dependent transport system permease family
B5M07_RS17815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5M07_RS17825	COG1960	acyl-CoA dehydrogenase activity
B5M07_RS17835	COG1024	Enoyl-CoA hydratase
B5M07_RS17840	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS17855	COG0318	PFAM AMP-dependent synthetase and ligase
B5M07_RS17885	COG2207	Transcriptional regulator
B5M07_RS17895	COG4584	PFAM Integrase catalytic
B5M07_RS17900	COG1484	DNA-dependent DNA replication
B5M07_RS17905	COG4584	PFAM Integrase catalytic
B5M07_RS17925	COG1335	isochorismatase
B5M07_RS17950	COG0411	ABC transporter
B5M07_RS17960	COG0174	glutamine synthetase
B5M07_RS17965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B5M07_RS17965	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B5M07_RS17980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5M07_RS17985	COG2222	sugar isomerase
B5M07_RS17990	COG2423	ornithine cyclodeaminase activity
B5M07_RS17995	COG1609	Transcriptional regulator
B5M07_RS18000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B5M07_RS18015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5M07_RS18025	COG3620	sequence-specific DNA binding
B5M07_RS18030	COG1431	PFAM Stem cell self-renewal protein Piwi
B5M07_RS18055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B5M07_RS18060	COG1192	Involved in chromosome partitioning
B5M07_RS18065	COG1475	DNA binding
B5M07_RS18070	COG1414	Transcriptional regulator
B5M07_RS18075	COG3609	addiction module antidote protein, CC2985 family
B5M07_RS18095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B5M07_RS18100	COG3311	Transcriptional regulator
B5M07_RS18120	COG3436	PFAM IS66 Orf2 family protein
B5M07_RS18125	COG4372	Transposase
B5M07_RS18140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5M07_RS18215	COG0556	nucleotide-excision repair
B5M07_RS18235	COG3843	relaxase mobilization nuclease domain protein
B5M07_RS18240	COG3505	Type IV secretory pathway VirD4
B5M07_RS18270	COG0419	ATPase involved in DNA repair
B5M07_RS18280	COG0419	ATPase involved in DNA repair
B5M07_RS18290	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B5M07_RS18305	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B5M07_RS18310	COG2948	multi-organism process
B5M07_RS18320	COG3736	Type IV secretory pathway, component VirB8
B5M07_RS18340	COG0741	lytic transglycosylase activity
B5M07_RS18340	COG1196	nuclear chromosome segregation
B5M07_RS18340	COG0739	heme binding
B5M07_RS18350	COG3451	type IV secretory pathway VirB4
B5M07_RS18365	COG1196	nuclear chromosome segregation
B5M07_RS18365	COG0739	heme binding
B5M07_RS18365	COG0741	lytic transglycosylase activity
B5M07_RS18390	COG0183	Belongs to the thiolase family
B5M07_RS18430	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5M07_RS18430	COG1024	Enoyl-CoA hydratase
B5M07_RS18450	COG1454	alcohol dehydrogenase
B5M07_RS18455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5M07_RS18470	COG1475	DNA binding
B5M07_RS18535	COG1192	Involved in chromosome partitioning
B5M07_RS18540	COG1475	DNA binding
B5M07_RS18545	COG1414	Transcriptional regulator
B5M07_RS18580	COG3609	addiction module antidote protein, CC2985 family
B5M07_RS18595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B5M07_RS18605	COG0655	NAD(P)H dehydrogenase (quinone) activity
B5M07_RS18610	COG1741	Belongs to the pirin family
B5M07_RS18615	COG0435	Glutathione S-transferase
B5M07_RS18620	COG2514	catechol 2,3-dioxygenase activity
B5M07_RS18635	COG0583	DNA-binding transcription factor activity
B5M07_RS18675	COG3485	protocatechuate 3,4-dioxygenase
B5M07_RS18725	COG1442	glycosyl transferase family 8
B5M07_RS18725	COG1216	Glycosyl transferase, family 2
B5M07_RS18735	COG3386	PFAM SMP-30 Gluconolaconase
B5M07_RS18755	COG1028	Short-chain dehydrogenase reductase Sdr
B5M07_RS18770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5M07_RS18775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B5M07_RS18820	COG0662	Cupin 2, conserved barrel domain protein
B5M07_RS18820	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B5M07_RS18825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5M07_RS18865	COG1192	Involved in chromosome partitioning
B5M07_RS18880	COG1091	dTDP-4-dehydrorhamnose reductase activity
B5M07_RS18890	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B5M07_RS18895	COG1216	Glycosyl transferase, family 2
B5M07_RS18905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5M07_RS18910	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B5M07_RS18915	COG1192	Involved in chromosome partitioning
B5M07_RS18950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B5M07_RS19005	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B5M07_RS19010	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5M07_RS19040	COG0410	ABC transporter
B5M07_RS19045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B5M07_RS19060	COG3135	benzoate transporter
B5M07_RS19125	COG4638	Rieske (2fe-2S)
B5M07_RS19135	COG3384	dioxygenase
B5M07_RS19155	COG1414	Transcriptional regulator
B5M07_RS19165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B5M07_RS19170	COG0183	Belongs to the thiolase family
B5M07_RS19175	COG2962	Rard protein
B5M07_RS19180	COG1309	transcriptional regulator
B5M07_RS19185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B5M07_RS19190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B5M07_RS19205	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B5M07_RS19205	COG1082	Xylose isomerase domain protein TIM barrel
B5M07_RS19210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B5M07_RS19215	COG3485	protocatechuate 3,4-dioxygenase
B5M07_RS19220	COG3485	protocatechuate 3,4-dioxygenase
B5M07_RS19230	COG2267	carboxylic ester hydrolase activity
B5M07_RS19240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B5M07_RS19245	COG1648	precorrin-2 dehydrogenase activity
B5M07_RS19245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5M07_RS19250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B5M07_RS19255	COG0243	molybdopterin cofactor binding
B5M07_RS19260	COG2146	nitrite reductase [NAD(P)H] activity
B5M07_RS19265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5M07_RS19270	COG1116	anion transmembrane transporter activity
B5M07_RS19270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5M07_RS19275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B5M07_RS19280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5M07_RS19285	COG1116	anion transmembrane transporter activity
B5M07_RS19285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5M07_RS19290	COG3707	response regulator
B5M07_RS19300	COG3206	protein involved in exopolysaccharide biosynthesis
B5M07_RS19300	COG0489	protein tyrosine kinase activity