locus-tag	class	description
DSM110093_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DSM110093_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DSM110093_RS00070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DSM110093_RS00095	COG0443	Heat shock 70 kDa protein
DSM110093_RS00100	COG0484	heat shock protein binding
DSM110093_RS00105	COG2003	Belongs to the UPF0758 family
DSM110093_RS00120	COG0653	protein targeting
DSM110093_RS00125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM110093_RS00130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DSM110093_RS00135	COG0494	nUDIX hydrolase
DSM110093_RS00140	COG1597	lipid kinase activity
DSM110093_RS00150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DSM110093_RS00165	COG0779	Required for maturation of 30S ribosomal subunits
DSM110093_RS00170	COG4533	DNA binding
DSM110093_RS00180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM110093_RS00190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSM110093_RS00230	COG3034	peptidoglycan biosynthetic process
DSM110093_RS00235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DSM110093_RS00240	COG1132	(ABC) transporter
DSM110093_RS00245	COG1132	(ABC) transporter
DSM110093_RS00250	COG0617	tRNA 3'-terminal CCA addition
DSM110093_RS00255	COG0494	nUDIX hydrolase
DSM110093_RS00265	COG0494	nUDIX hydrolase
DSM110093_RS00270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM110093_RS00275	COG0137	argininosuccinate synthase activity
DSM110093_RS00290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM110093_RS00295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM110093_RS00300	COG0281	malic enzyme
DSM110093_RS00300	COG0280	phosphate acetyltransferase
DSM110093_RS00305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DSM110093_RS00310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DSM110093_RS00315	COG1420	regulation of RNA biosynthetic process
DSM110093_RS00320	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DSM110093_RS00325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DSM110093_RS00330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DSM110093_RS00345	COG0357	Ribosomal RNA small subunit methyltransferase G
DSM110093_RS00350	COG0445	tRNA wobble uridine modification
DSM110093_RS00355	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DSM110093_RS00360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DSM110093_RS00365	COG1981	membrane
DSM110093_RS00370	COG0424	maF-like protein
DSM110093_RS00375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DSM110093_RS00380	COG0237	dephospho-CoA kinase activity
DSM110093_RS00385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DSM110093_RS00390	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DSM110093_RS00420	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DSM110093_RS00425	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DSM110093_RS00440	COG1074	ATP-dependent DNA helicase activity
DSM110093_RS00445	COG2887	Belongs to the helicase family. UvrD subfamily
DSM110093_RS00450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DSM110093_RS00455	COG3178	'Phosphotransferase
DSM110093_RS00460	COG0802	atpase or kinase
DSM110093_RS00480	COG1999	signal sequence binding
DSM110093_RS00485	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DSM110093_RS00495	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DSM110093_RS00505	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DSM110093_RS00530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DSM110093_RS00535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DSM110093_RS00570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DSM110093_RS00575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DSM110093_RS00605	COG0174	glutamine synthetase
DSM110093_RS00620	COG3474	cytochrome
DSM110093_RS00625	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DSM110093_RS00630	COG0408	coproporphyrinogen oxidase activity
DSM110093_RS00635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DSM110093_RS00640	COG0181	hydroxymethylbilane synthase activity
DSM110093_RS00680	COG3191	aminopeptidase activity
DSM110093_RS00685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DSM110093_RS00690	COG1396	sequence-specific DNA binding
DSM110093_RS00715	COG0784	Response regulator, receiver
DSM110093_RS00740	COG1295	ribonuclease BN
DSM110093_RS00745	COG2116	formate transmembrane transporter activity
DSM110093_RS00770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS00780	COG2358	TRAP transporter, solute receptor (TAXI family
DSM110093_RS00795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSM110093_RS00805	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM110093_RS00815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110093_RS00820	COG0047	phosphoribosylformylglycinamidine synthase activity
DSM110093_RS00830	COG2995	paraquat-inducible protein a
DSM110093_RS00835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DSM110093_RS00835	COG3008	intermembrane lipid transfer
DSM110093_RS00855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM110093_RS00860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM110093_RS00865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DSM110093_RS00870	COG1137	ATPase activity
DSM110093_RS00885	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DSM110093_RS00885	COG0517	IMP dehydrogenase activity
DSM110093_RS00890	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DSM110093_RS00895	COG3327	negative regulation of DNA-templated transcription, initiation
DSM110093_RS00900	COG2030	dehydratase
DSM110093_RS00900	COG1012	belongs to the aldehyde dehydrogenase family
DSM110093_RS00905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DSM110093_RS00910	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM110093_RS00915	COG3396	Phenylacetate-CoA oxygenase
DSM110093_RS00920	COG3460	Phenylacetate-CoA oxygenase
DSM110093_RS00925	COG3396	Phenylacetate-CoA oxygenase
DSM110093_RS00940	COG0697	spore germination
DSM110093_RS00945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DSM110093_RS00950	COG4143	(ABC) transporter
DSM110093_RS00960	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DSM110093_RS00970	COG2808	Putative FMN-binding domain
DSM110093_RS00975	COG0625	glutathione transferase activity
DSM110093_RS00995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM110093_RS01000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DSM110093_RS01010	COG1177	transmembrane transport
DSM110093_RS01015	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM110093_RS01080	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DSM110093_RS01095	COG4372	Transposase
DSM110093_RS01120	COG1968	undecaprenyl-diphosphatase activity
DSM110093_RS01140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DSM110093_RS01150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DSM110093_RS01160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM110093_RS01165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM110093_RS01175	COG0776	regulation of translation
DSM110093_RS01180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DSM110093_RS01185	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DSM110093_RS01200	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM110093_RS01220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DSM110093_RS01225	COG0142	geranyltranstransferase activity
DSM110093_RS01230	COG1722	exodeoxyribonuclease VII activity
DSM110093_RS01235	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS01240	COG1846	Transcriptional regulator
DSM110093_RS01245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSM110093_RS01250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DSM110093_RS01270	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110093_RS01270	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM110093_RS01280	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM110093_RS01285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110093_RS01325	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DSM110093_RS01350	COG0747	negative chemotaxis
DSM110093_RS01355	COG0601	transmembrane transport
DSM110093_RS01360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS01365	COG4172	Belongs to the ABC transporter superfamily
DSM110093_RS01375	COG4948	Mandelate Racemase Muconate Lactonizing
DSM110093_RS01385	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS01395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110093_RS01410	COG0183	Belongs to the thiolase family
DSM110093_RS01415	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM110093_RS01415	COG1024	Enoyl-CoA hydratase
DSM110093_RS01425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110093_RS01435	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DSM110093_RS01450	COG0517	IMP dehydrogenase activity
DSM110093_RS01450	COG4175	Glycine betaine
DSM110093_RS01455	COG4176	ABC-type proline glycine betaine transport system permease component
DSM110093_RS01475	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DSM110093_RS01490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DSM110093_RS01495	COG2855	membrane
DSM110093_RS01545	COG1231	oxidoreductase activity
DSM110093_RS01570	COG0583	DNA-binding transcription factor activity
DSM110093_RS01610	COG2814	Major facilitator Superfamily
DSM110093_RS01615	COG3328	transposase activity
DSM110093_RS01620	COG2824	Alkylphosphonate utilization operon protein PhnA
DSM110093_RS01625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM110093_RS01635	COG1609	Transcriptional regulator
DSM110093_RS01650	COG3547	Transposase (IS116 IS110 IS902 family)
DSM110093_RS01675	COG0024	Methionine aminopeptidase
DSM110093_RS01705	COG3447	MASE1 domain protein
DSM110093_RS01705	COG5001	Diguanylate cyclase
DSM110093_RS01705	COG5002	protein histidine kinase activity
DSM110093_RS01720	COG0473	3-isopropylmalate dehydrogenase activity
DSM110093_RS01735	COG0066	3-isopropylmalate dehydratase activity
DSM110093_RS01745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSM110093_RS01750	COG3264	Mechanosensitive ion channel
DSM110093_RS01750	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DSM110093_RS01755	COG0799	negative regulation of ribosome biogenesis
DSM110093_RS01760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DSM110093_RS01770	COG0277	FAD linked oxidase domain protein
DSM110093_RS01775	COG0277	FAD linked oxidase domain protein
DSM110093_RS01785	COG0247	lactate metabolic process
DSM110093_RS01795	COG0071	Belongs to the small heat shock protein (HSP20) family
DSM110093_RS01805	COG3443	Belongs to the bacterial solute-binding protein 9 family
DSM110093_RS01815	COG1012	belongs to the aldehyde dehydrogenase family
DSM110093_RS01850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DSM110093_RS01855	COG2897	thiosulfate sulfurtransferase activity
DSM110093_RS01870	COG0004	ammonium transporteR
DSM110093_RS01885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM110093_RS01895	COG0584	glycerophosphoryl diester phosphodiesterase
DSM110093_RS01905	COG2154	pterin-4-alpha-carbinolamine dehydratase
DSM110093_RS01910	COG0668	transmembrane transport
DSM110093_RS01915	COG0678	peroxiredoxin activity
DSM110093_RS01925	COG0742	ribosomal rna small subunit methyltransferase
DSM110093_RS01960	COG1609	Transcriptional regulator
DSM110093_RS01965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS01980	COG0129	dihydroxy-acid dehydratase activity
DSM110093_RS01985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM110093_RS01990	COG0024	Methionine aminopeptidase
DSM110093_RS01995	COG1489	DNA binding
DSM110093_RS02000	COG1058	Belongs to the CinA family
DSM110093_RS02000	COG1546	Belongs to the CinA family
DSM110093_RS02030	COG2423	ornithine cyclodeaminase activity
DSM110093_RS02040	COG1671	Belongs to the UPF0178 family
DSM110093_RS02045	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DSM110093_RS02050	COG0679	Auxin Efflux Carrier
DSM110093_RS02070	COG2050	protein possibly involved in aromatic compounds catabolism
DSM110093_RS02080	COG0791	NLP P60 protein
DSM110093_RS02085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM110093_RS02095	COG0288	reversible hydration of carbon dioxide
DSM110093_RS02100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DSM110093_RS02120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DSM110093_RS02135	COG1194	a g-specific adenine glycosylase
DSM110093_RS02145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DSM110093_RS02155	COG1663	tetraacyldisaccharide 4'-kinase activity
DSM110093_RS02170	COG0483	inositol monophosphate 1-phosphatase activity
DSM110093_RS02175	COG0312	modulator of DNA gyrase
DSM110093_RS02215	COG0495	leucyl-tRNA aminoacylation
DSM110093_RS02230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DSM110093_RS02245	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS02250	COG0708	Exodeoxyribonuclease III
DSM110093_RS02255	COG3118	belongs to the thioredoxin family
DSM110093_RS02265	COG2835	tetraacyldisaccharide 4'-kinase activity
DSM110093_RS02270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM110093_RS02275	COG0154	amidase activity
DSM110093_RS02280	COG0436	Aminotransferase
DSM110093_RS02285	COG1674	ftsk spoiiie
DSM110093_RS02305	COG0405	Gamma-glutamyltransferase
DSM110093_RS02315	COG1956	GAF domain-containing protein
DSM110093_RS02320	COG0564	pseudouridine synthase activity
DSM110093_RS02325	COG0450	alkyl hydroperoxide reductase
DSM110093_RS02330	COG0438	transferase activity, transferring glycosyl groups
DSM110093_RS02335	COG1185	polyribonucleotide nucleotidyltransferase activity
DSM110093_RS02340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DSM110093_RS02355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DSM110093_RS02365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DSM110093_RS02370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DSM110093_RS02400	COG0138	bifunctional purine biosynthesis protein purh
DSM110093_RS02405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DSM110093_RS02415	COG0612	Peptidase, M16
DSM110093_RS02420	COG0612	Peptidase, M16
DSM110093_RS02425	COG1012	belongs to the aldehyde dehydrogenase family
DSM110093_RS02435	COG0803	Belongs to the bacterial solute-binding protein 9 family
DSM110093_RS02440	COG1121	(ABC) transporter
DSM110093_RS02445	COG1321	iron dependent repressor
DSM110093_RS02445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSM110093_RS02450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSM110093_RS02455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DSM110093_RS02510	COG3383	formate dehydrogenase (NAD+) activity
DSM110093_RS02525	COG4191	Histidine kinase
DSM110093_RS02540	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS02560	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DSM110093_RS02565	COG1178	ABC-type Fe3 transport system permease component
DSM110093_RS02570	COG1840	ABC-type Fe3 transport system, periplasmic component
DSM110093_RS02575	COG0625	glutathione transferase activity
DSM110093_RS02590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSM110093_RS02600	COG0284	orotidine-5'-phosphate decarboxylase activity
DSM110093_RS02620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DSM110093_RS02665	COG0250	Participates in transcription elongation, termination and antitermination
DSM110093_RS02670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DSM110093_RS02675	COG0081	regulation of translation
DSM110093_RS02680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DSM110093_RS02685	COG0222	ribosome binding
DSM110093_RS02690	COG0085	RNA polymerase activity
DSM110093_RS02695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DSM110093_RS02700	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS02715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DSM110093_RS02720	COG0049	tRNA binding
DSM110093_RS02725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DSM110093_RS02730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DSM110093_RS02735	COG0051	transcription antitermination factor activity, RNA binding
DSM110093_RS02740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DSM110093_RS02745	COG0088	Forms part of the polypeptide exit tunnel
DSM110093_RS02750	COG0089	rRNA binding
DSM110093_RS02760	COG3239	Fatty acid desaturase
DSM110093_RS02770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DSM110093_RS02775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DSM110093_RS02780	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DSM110093_RS02785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DSM110093_RS02790	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DSM110093_RS02815	COG0255	Belongs to the universal ribosomal protein uL29 family
DSM110093_RS02820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DSM110093_RS02825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DSM110093_RS02830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DSM110093_RS02835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DSM110093_RS02840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DSM110093_RS02845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DSM110093_RS02850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DSM110093_RS02855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DSM110093_RS02860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DSM110093_RS02865	COG1841	ribosomal large subunit assembly
DSM110093_RS02870	COG0200	Binds to the 23S rRNA
DSM110093_RS02875	COG0201	protein transport
DSM110093_RS02880	COG0563	adenylate kinase activity
DSM110093_RS02885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DSM110093_RS02890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DSM110093_RS02895	COG0202	RNA polymerase activity
DSM110093_RS02900	COG0203	ribosomal protein L17
DSM110093_RS02905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DSM110093_RS02915	COG0564	pseudouridine synthase activity
DSM110093_RS02920	COG0546	phosphoglycolate phosphatase activity
DSM110093_RS02930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM110093_RS02935	COG4597	amino acid ABC transporter
DSM110093_RS02940	COG0765	amino acid transport
DSM110093_RS02945	COG1126	abc transporter atp-binding protein
DSM110093_RS02955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DSM110093_RS02960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DSM110093_RS02970	COG0706	membrane insertase activity
DSM110093_RS02975	COG5001	Diguanylate cyclase
DSM110093_RS02975	COG3300	MHYT domain
DSM110093_RS02980	COG0037	tRNA processing
DSM110093_RS02985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DSM110093_RS02990	COG0594	ribonuclease P activity
DSM110093_RS02995	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DSM110093_RS03050	COG1366	Belongs to the anti-sigma-factor antagonist family
DSM110093_RS03055	COG0784	Response regulator, receiver
DSM110093_RS03055	COG2205	protein histidine kinase activity
DSM110093_RS03100	COG2197	response regulator
DSM110093_RS03125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM110093_RS03130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM110093_RS03135	COG1120	ATPase activity
DSM110093_RS03140	COG4774	siderophore transport
DSM110093_RS03150	COG0501	Belongs to the peptidase M48B family
DSM110093_RS03165	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS03170	COG0583	DNA-binding transcription factor activity
DSM110093_RS03180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM110093_RS03185	COG0765	amino acid transport
DSM110093_RS03195	COG5002	protein histidine kinase activity
DSM110093_RS03205	COG0183	Belongs to the thiolase family
DSM110093_RS03210	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS03215	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM110093_RS03220	COG2205	protein histidine kinase activity
DSM110093_RS03220	COG2202	Pas domain
DSM110093_RS03245	COG0411	ABC transporter
DSM110093_RS03255	COG2197	response regulator
DSM110093_RS03260	COG4191	Histidine kinase
DSM110093_RS03260	COG2205	protein histidine kinase activity
DSM110093_RS03260	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS03265	COG4566	intracellular signal transduction
DSM110093_RS03280	COG2205	protein histidine kinase activity
DSM110093_RS03285	COG1271	oxidase subunit
DSM110093_RS03290	COG1294	oxidase, subunit
DSM110093_RS03300	COG0604	alcohol dehydrogenase
DSM110093_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS03300	COG3321	synthase
DSM110093_RS03305	COG0697	spore germination
DSM110093_RS03315	COG1131	(ABC) transporter
DSM110093_RS03320	COG0842	Transport permease protein
DSM110093_RS03340	COG0322	excinuclease ABC activity
DSM110093_RS03345	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DSM110093_RS03355	COG0314	molybdopterin synthase activity
DSM110093_RS03360	COG0346	lactoylglutathione lyase activity
DSM110093_RS03375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DSM110093_RS03395	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DSM110093_RS03400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DSM110093_RS03410	COG0540	Belongs to the ATCase OTCase family
DSM110093_RS03415	COG1573	uracil-dna glycosylase
DSM110093_RS03420	COG1280	lysine exporter protein (LysE YggA)
DSM110093_RS03425	COG0521	Mo-molybdopterin cofactor biosynthetic process
DSM110093_RS03435	COG1678	Uncharacterized ACR, COG1678
DSM110093_RS03440	COG0009	L-threonylcarbamoyladenylate synthase
DSM110093_RS03445	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS03480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DSM110093_RS03485	COG0746	molybdenum cofactor guanylyltransferase activity
DSM110093_RS03490	COG0303	'Molybdopterin
DSM110093_RS03500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSM110093_RS03515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DSM110093_RS03520	COG0142	geranyltranstransferase activity
DSM110093_RS03530	COG2890	protein-(glutamine-N5) methyltransferase activity
DSM110093_RS03555	COG2818	Glycosylase
DSM110093_RS03560	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DSM110093_RS03565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM110093_RS03570	COG0287	Prephenate dehydrogenase
DSM110093_RS03585	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DSM110093_RS03610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM110093_RS03620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM110093_RS03625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DSM110093_RS03630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DSM110093_RS03635	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DSM110093_RS03640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DSM110093_RS03660	COG2267	carboxylic ester hydrolase activity
DSM110093_RS03670	COG2983	Belongs to the UPF0260 family
DSM110093_RS03675	COG0196	riboflavin kinase activity
DSM110093_RS03680	COG2030	dehydratase
DSM110093_RS03690	COG1227	inorganic diphosphatase activity
DSM110093_RS03705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DSM110093_RS03710	COG0459	protein refolding
DSM110093_RS03715	COG2201	protein-glutamate methylesterase activity
DSM110093_RS03720	COG4251	negative regulation of phosphorylation
DSM110093_RS03745	COG3454	Phosphonate metabolism
DSM110093_RS03750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DSM110093_RS03755	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DSM110093_RS03765	COG0071	Belongs to the small heat shock protein (HSP20) family
DSM110093_RS03775	COG0529	Catalyzes the synthesis of activated sulfate
DSM110093_RS03775	COG2046	Belongs to the sulfate adenylyltransferase family
DSM110093_RS03780	COG0492	ferredoxin-NADP+ reductase activity
DSM110093_RS03785	COG1522	sequence-specific DNA binding
DSM110093_RS03800	COG1496	oxidoreductase activity
DSM110093_RS03810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DSM110093_RS03830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM110093_RS03835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM110093_RS03840	COG1435	thymidine kinase activity
DSM110093_RS03865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DSM110093_RS03870	COG0596	Alpha beta hydrolase
DSM110093_RS03885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSM110093_RS03890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DSM110093_RS03895	COG3237	CsbD-like
DSM110093_RS03905	COG0019	diaminopimelate decarboxylase activity
DSM110093_RS03925	COG0281	malic enzyme
DSM110093_RS03925	COG0280	phosphate acetyltransferase
DSM110093_RS03935	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DSM110093_RS03940	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DSM110093_RS03945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DSM110093_RS03960	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110093_RS03975	COG1024	Enoyl-CoA hydratase
DSM110093_RS03975	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM110093_RS03985	COG0183	Belongs to the thiolase family
DSM110093_RS03990	COG0625	glutathione transferase activity
DSM110093_RS03995	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS04005	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS04010	COG0789	Transcriptional regulator
DSM110093_RS04015	COG2197	response regulator
DSM110093_RS04040	COG0534	Mate efflux family protein
DSM110093_RS04045	COG1393	Belongs to the ArsC family
DSM110093_RS04060	COG0737	Belongs to the 5'-nucleotidase family
DSM110093_RS04075	COG0583	DNA-binding transcription factor activity
DSM110093_RS04080	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS04085	COG0022	dehydrogenase e1 component
DSM110093_RS04090	COG4948	Mandelate Racemase Muconate Lactonizing
DSM110093_RS04095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM110093_RS04120	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DSM110093_RS04130	COG1643	Atp-dependent helicase
DSM110093_RS04135	COG1703	isobutyryl-CoA mutase activity
DSM110093_RS04160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DSM110093_RS04195	COG0632	four-way junction helicase activity
DSM110093_RS04200	COG2255	four-way junction helicase activity
DSM110093_RS04210	COG0824	Thioesterase
DSM110093_RS04230	COG0823	Involved in the tonB-independent uptake of proteins
DSM110093_RS04235	COG2885	chlorophyll binding
DSM110093_RS04245	COG0037	tRNA processing
DSM110093_RS04250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM110093_RS04265	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DSM110093_RS04270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DSM110093_RS04290	COG1201	RNA secondary structure unwinding
DSM110093_RS04340	COG4964	Belongs to the GSP D family
DSM110093_RS04365	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DSM110093_RS04380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DSM110093_RS04380	COG1754	DNA topoisomerase type I activity
DSM110093_RS04385	COG0758	DNA mediated transformation
DSM110093_RS04390	COG0312	modulator of DNA gyrase
DSM110093_RS04400	COG0109	protoheme IX farnesyltransferase activity
DSM110093_RS04410	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DSM110093_RS04420	COG3346	SURF1 family
DSM110093_RS04445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DSM110093_RS04450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DSM110093_RS04455	COG0659	secondary active sulfate transmembrane transporter activity
DSM110093_RS04460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DSM110093_RS04475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DSM110093_RS04480	COG4149	molybdate abc transporter
DSM110093_RS04485	COG0725	ABC transporter, periplasmic molybdate-binding protein
DSM110093_RS04500	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS04510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM110093_RS04520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM110093_RS04540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM110093_RS04540	COG2010	Cytochrome c
DSM110093_RS04565	COG1132	(ABC) transporter
DSM110093_RS04570	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110093_RS04585	COG1490	D-aminoacyl-tRNA deacylase activity
DSM110093_RS04615	COG3853	Toxic anion resistance protein (TelA)
DSM110093_RS04635	COG0590	tRNA wobble adenosine to inosine editing
DSM110093_RS04650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DSM110093_RS04670	COG0154	amidase activity
DSM110093_RS04675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM110093_RS04680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DSM110093_RS04695	COG0670	Belongs to the BI1 family
DSM110093_RS04700	COG1396	sequence-specific DNA binding
DSM110093_RS04705	COG0483	inositol monophosphate 1-phosphatase activity
DSM110093_RS04720	COG0402	S-adenosylhomocysteine deaminase activity
DSM110093_RS04725	COG2239	Acts as a magnesium transporter
DSM110093_RS04730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DSM110093_RS04735	COG1692	metallophosphoesterase
DSM110093_RS04740	COG0471	metal ion transport
DSM110093_RS04740	COG3273	potassium ion transport
DSM110093_RS04745	COG0471	metal ion transport
DSM110093_RS04745	COG3273	potassium ion transport
DSM110093_RS04750	COG0217	transcriptional regulatory protein
DSM110093_RS04770	COG1309	transcriptional regulator
DSM110093_RS04790	COG1396	sequence-specific DNA binding
DSM110093_RS04790	COG3800	Transcriptional regulator
DSM110093_RS04795	COG2814	Major facilitator Superfamily
DSM110093_RS04800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM110093_RS04830	COG4770	biotin carboxylase activity
DSM110093_RS04840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM110093_RS04840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM110093_RS04850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DSM110093_RS04865	COG0248	Ppx GppA phosphatase
DSM110093_RS04870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DSM110093_RS04880	COG0628	permease
DSM110093_RS04885	COG2195	Cleaves the N-terminal amino acid of tripeptides
DSM110093_RS04890	COG0442	prolyl-tRNA aminoacylation
DSM110093_RS04905	COG1136	(ABC) transporter
DSM110093_RS04925	COG3328	transposase activity
DSM110093_RS04935	COG0187	DNA topoisomerase II activity
DSM110093_RS04950	COG2267	carboxylic ester hydrolase activity
DSM110093_RS04955	COG0534	Mate efflux family protein
DSM110093_RS04980	COG1846	Transcriptional regulator
DSM110093_RS05010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DSM110093_RS05020	COG1278	Cold shock
DSM110093_RS05025	COG1393	Belongs to the ArsC family
DSM110093_RS05040	COG3220	belongs to the UPF0276 family
DSM110093_RS05050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DSM110093_RS05075	COG3243	poly(R)-hydroxyalkanoic acid synthase
DSM110093_RS05090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM110093_RS05095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110093_RS05100	COG0174	glutamine synthetase
DSM110093_RS05105	COG0519	Catalyzes the synthesis of GMP from XMP
DSM110093_RS05110	COG0174	glutamine synthetase
DSM110093_RS05115	COG4160	amino acid transport
DSM110093_RS05120	COG4215	(ABC) transporter
DSM110093_RS05150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DSM110093_RS05155	COG0504	CTP synthase activity
DSM110093_RS05180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSM110093_RS05200	COG0697	spore germination
DSM110093_RS05215	COG0546	phosphoglycolate phosphatase activity
DSM110093_RS05275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DSM110093_RS05275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DSM110093_RS05295	COG1215	transferase activity, transferring glycosyl groups
DSM110093_RS05300	COG0438	transferase activity, transferring glycosyl groups
DSM110093_RS05315	COG0489	protein tyrosine kinase activity
DSM110093_RS05315	COG3206	protein involved in exopolysaccharide biosynthesis
DSM110093_RS05330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DSM110093_RS05355	COG1741	Belongs to the pirin family
DSM110093_RS05360	COG1760	l-serine dehydratase
DSM110093_RS05365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DSM110093_RS05380	COG0330	HflC and HflK could
DSM110093_RS05410	COG0151	Belongs to the GarS family
DSM110093_RS05415	COG1570	exodeoxyribonuclease VII activity
DSM110093_RS05425	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM110093_RS05430	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DSM110093_RS05435	COG0552	protein localization to endoplasmic reticulum
DSM110093_RS05440	COG1285	pathogenesis
DSM110093_RS05460	COG1469	GTP cyclohydrolase I activity
DSM110093_RS05470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM110093_RS05475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM110093_RS05480	COG0752	glycyl-tRNA synthetase alpha subunit
DSM110093_RS05495	COG0751	glycine-tRNA ligase activity
DSM110093_RS05500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM110093_RS05500	COG0574	Belongs to the PEP-utilizing enzyme family
DSM110093_RS05510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DSM110093_RS05515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DSM110093_RS05520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSM110093_RS05530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DSM110093_RS05560	COG1802	Transcriptional regulator
DSM110093_RS05570	COG0505	Belongs to the CarA family
DSM110093_RS05575	COG1610	YqeY-like protein
DSM110093_RS05590	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DSM110093_RS05595	COG1304	FMN binding
DSM110093_RS05605	COG0210	DNA helicase
DSM110093_RS05615	COG0489	protein tyrosine kinase activity
DSM110093_RS05625	COG2001	Belongs to the MraZ family
DSM110093_RS05630	COG0275	rRNA processing
DSM110093_RS05645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSM110093_RS05655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM110093_RS05665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DSM110093_RS05670	COG2081	HI0933 family
DSM110093_RS05685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DSM110093_RS05690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DSM110093_RS05710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DSM110093_RS05715	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM110093_RS05720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DSM110093_RS05730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DSM110093_RS05740	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM110093_RS05745	COG0497	DNA recombination
DSM110093_RS05760	COG0006	proline dipeptidase activity
DSM110093_RS05780	COG0484	heat shock protein binding
DSM110093_RS05800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM110093_RS05820	COG0308	aminopeptidase N
DSM110093_RS05830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DSM110093_RS05835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DSM110093_RS05840	COG1943	Transposase
DSM110093_RS05845	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS05860	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DSM110093_RS05875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS05880	COG0601	transmembrane transport
DSM110093_RS05890	COG4172	Belongs to the ABC transporter superfamily
DSM110093_RS05895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM110093_RS05900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110093_RS05905	COG1473	amidohydrolase
DSM110093_RS05910	COG1473	amidohydrolase
DSM110093_RS05920	COG1519	Transferase
DSM110093_RS05925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DSM110093_RS05945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DSM110093_RS05950	COG0546	phosphoglycolate phosphatase activity
DSM110093_RS05965	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS05985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM110093_RS05990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM110093_RS05995	COG4770	biotin carboxylase activity
DSM110093_RS06010	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DSM110093_RS06020	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM110093_RS06025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM110093_RS06035	COG0649	NAD binding
DSM110093_RS06045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM110093_RS06045	COG3743	rRNA binding
DSM110093_RS06080	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DSM110093_RS06085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM110093_RS06100	COG0713	ATP synthesis coupled electron transport
DSM110093_RS06115	COG1007	ATP synthesis coupled electron transport
DSM110093_RS06125	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DSM110093_RS06140	COG0513	Belongs to the DEAD box helicase family
DSM110093_RS06150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DSM110093_RS06160	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS06170	COG3842	ATPase activity
DSM110093_RS06190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM110093_RS06195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM110093_RS06200	COG0805	protein transport
DSM110093_RS06210	COG0739	heme binding
DSM110093_RS06210	COG1388	LysM domain
DSM110093_RS06215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM110093_RS06220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DSM110093_RS06225	COG0300	oxidoreductase activity
DSM110093_RS06245	COG0175	sulfate reduction
DSM110093_RS06250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DSM110093_RS06260	COG1648	precorrin-2 dehydrogenase activity
DSM110093_RS06260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DSM110093_RS06265	COG1522	sequence-specific DNA binding
DSM110093_RS06270	COG0149	triose-phosphate isomerase activity
DSM110093_RS06295	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM110093_RS06300	COG0189	ligase activity
DSM110093_RS06300	COG4067	protein conserved in archaea
DSM110093_RS06320	COG0343	queuine tRNA-ribosyltransferase activity
DSM110093_RS06325	COG1902	pentaerythritol trinitrate reductase activity
DSM110093_RS06330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM110093_RS06345	COG0406	alpha-ribazole phosphatase activity
DSM110093_RS06375	COG0156	8-amino-7-oxononanoate synthase activity
DSM110093_RS06385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DSM110093_RS06400	COG0436	Aminotransferase
DSM110093_RS06405	COG0860	N-Acetylmuramoyl-L-alanine amidase
DSM110093_RS06410	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DSM110093_RS06415	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DSM110093_RS06435	COG0028	Belongs to the TPP enzyme family
DSM110093_RS06440	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DSM110093_RS06460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DSM110093_RS06485	COG1764	response to oxidative stress
DSM110093_RS06505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM110093_RS06515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM110093_RS06525	COG0010	Belongs to the arginase family
DSM110093_RS06535	COG1238	metal cluster binding
DSM110093_RS06550	COG1012	belongs to the aldehyde dehydrogenase family
DSM110093_RS06560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110093_RS06590	COG4948	Mandelate Racemase Muconate Lactonizing
DSM110093_RS06595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS06610	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DSM110093_RS06645	COG0583	DNA-binding transcription factor activity
DSM110093_RS06650	COG4681	YaeQ
DSM110093_RS06680	COG0798	PFAM Bile acid sodium symporter
DSM110093_RS06685	COG0431	NADPH-dependent FMN reductase
DSM110093_RS06710	COG1366	Belongs to the anti-sigma-factor antagonist family
DSM110093_RS06715	COG1366	Belongs to the anti-sigma-factor antagonist family
DSM110093_RS06720	COG4175	Glycine betaine
DSM110093_RS06720	COG0517	IMP dehydrogenase activity
DSM110093_RS06725	COG4176	ABC-type proline glycine betaine transport system permease component
DSM110093_RS06745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DSM110093_RS06755	COG4536	flavin adenine dinucleotide binding
DSM110093_RS06765	COG4974	Belongs to the 'phage' integrase family
DSM110093_RS06780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DSM110093_RS06785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DSM110093_RS06790	COG0629	single-stranded DNA binding
DSM110093_RS06795	COG0741	lytic transglycosylase activity
DSM110093_RS06805	COG4172	Belongs to the ABC transporter superfamily
DSM110093_RS06810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS06815	COG0601	transmembrane transport
DSM110093_RS06825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DSM110093_RS06830	COG0528	UMP kinase activity
DSM110093_RS06835	COG0233	cytoplasmic translational termination
DSM110093_RS06840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DSM110093_RS06850	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DSM110093_RS06855	COG0750	zinc metalloprotease
DSM110093_RS06860	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM110093_RS06870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM110093_RS06875	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM110093_RS06880	COG3494	Protein of unknown function (DUF1009)
DSM110093_RS06885	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM110093_RS06890	COG0482	sulfurtransferase activity
DSM110093_RS06900	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS06905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DSM110093_RS06910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DSM110093_RS06920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DSM110093_RS06925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM110093_RS06935	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DSM110093_RS06940	COG1024	Enoyl-CoA hydratase
DSM110093_RS06955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM110093_RS06960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DSM110093_RS06965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DSM110093_RS06975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM110093_RS06980	COG1309	transcriptional regulator
DSM110093_RS06985	COG2326	polyphosphate kinase activity
DSM110093_RS06990	COG0596	Alpha beta hydrolase
DSM110093_RS06995	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DSM110093_RS07005	COG0697	spore germination
DSM110093_RS07045	COG0753	catalase activity
DSM110093_RS07060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DSM110093_RS07065	COG2010	Cytochrome c
DSM110093_RS07080	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DSM110093_RS07085	COG2867	negative regulation of translational initiation
DSM110093_RS07090	COG1546	Belongs to the CinA family
DSM110093_RS07095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DSM110093_RS07100	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DSM110093_RS07100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DSM110093_RS07105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSM110093_RS07110	COG3852	Histidine kinase
DSM110093_RS07115	COG2204	response regulator
DSM110093_RS07120	COG5000	phosphorelay sensor kinase activity
DSM110093_RS07125	COG2204	response regulator
DSM110093_RS07135	COG0569	domain protein
DSM110093_RS07140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM110093_RS07145	COG1923	regulation of RNA biosynthetic process
DSM110093_RS07150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DSM110093_RS07160	COG1187	pseudouridine synthase activity
DSM110093_RS07170	COG2084	Dehydrogenase
DSM110093_RS07190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DSM110093_RS07195	COG2814	Major facilitator Superfamily
DSM110093_RS07210	COG4166	transmembrane transport
DSM110093_RS07215	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS07230	COG2313	pseudouridylate synthase activity
DSM110093_RS07260	COG1612	heme a metabolic process
DSM110093_RS07275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSM110093_RS07280	COG5425	PFAM Usg family protein
DSM110093_RS07290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DSM110093_RS07295	COG0363	glucosamine-6-phosphate deaminase activity
DSM110093_RS07300	COG0166	Belongs to the GPI family
DSM110093_RS07305	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110093_RS07310	COG2202	Pas domain
DSM110093_RS07310	COG2205	protein histidine kinase activity
DSM110093_RS07320	COG2226	methyltransferase
DSM110093_RS07335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DSM110093_RS07335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM110093_RS07355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DSM110093_RS07360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSM110093_RS07370	COG0671	phosphoesterase, PA-phosphatase related
DSM110093_RS07375	COG1217	gtp-binding protein TYPA
DSM110093_RS07385	COG1522	sequence-specific DNA binding
DSM110093_RS07395	COG0538	isocitrate dehydrogenase activity
DSM110093_RS07410	COG2945	thiolester hydrolase activity
DSM110093_RS07415	COG1959	2 iron, 2 sulfur cluster binding
DSM110093_RS07425	COG0719	Fe-S assembly protein
DSM110093_RS07430	COG0396	ATPase activity
DSM110093_RS07435	COG0719	Fe-S assembly protein
DSM110093_RS07465	COG4589	Belongs to the CDS family
DSM110093_RS07480	COG0583	DNA-binding transcription factor activity
DSM110093_RS07485	COG2855	membrane
DSM110093_RS07490	COG1522	sequence-specific DNA binding
DSM110093_RS07520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DSM110093_RS07530	COG0248	Ppx GppA phosphatase
DSM110093_RS07535	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DSM110093_RS07545	COG3257	ureidoglycine aminohydrolase activity
DSM110093_RS07555	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DSM110093_RS07565	COG2351	hydroxyisourate hydrolase activity
DSM110093_RS07570	COG0583	DNA-binding transcription factor activity
DSM110093_RS07580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM110093_RS07590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DSM110093_RS07595	COG2011	ABC-type metal ion transport system permease component
DSM110093_RS07600	COG1464	Belongs to the NlpA lipoprotein family
DSM110093_RS07605	COG0235	Class ii aldolase
DSM110093_RS07620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSM110093_RS07645	COG0215	cysteine-tRNA ligase activity
DSM110093_RS07650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM110093_RS07665	COG2814	Major facilitator Superfamily
DSM110093_RS07710	COG0316	Belongs to the HesB IscA family
DSM110093_RS07715	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DSM110093_RS07725	COG0018	arginyl-trna synthetase
DSM110093_RS07735	COG1472	Belongs to the glycosyl hydrolase 3 family
DSM110093_RS07740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DSM110093_RS07745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DSM110093_RS07755	COG0717	Belongs to the dCTP deaminase family
DSM110093_RS07770	COG0776	regulation of translation
DSM110093_RS07775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM110093_RS07780	COG0416	fatty acid biosynthetic process
DSM110093_RS07785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DSM110093_RS07805	COG0488	(ABC) transporter
DSM110093_RS07820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DSM110093_RS07825	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DSM110093_RS07840	COG0148	phosphopyruvate hydratase activity
DSM110093_RS07845	COG0697	spore germination
DSM110093_RS07865	COG0513	Belongs to the DEAD box helicase family
DSM110093_RS07875	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DSM110093_RS07890	COG3956	TIGRFAM MazG family protein
DSM110093_RS07895	COG1473	amidohydrolase
DSM110093_RS07900	COG0010	Belongs to the arginase family
DSM110093_RS07915	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DSM110093_RS07920	COG2890	protein-(glutamine-N5) methyltransferase activity
DSM110093_RS07935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DSM110093_RS07940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DSM110093_RS07950	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DSM110093_RS07965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM110093_RS07980	COG3577	Aspartyl protease
DSM110093_RS07985	COG2095	MarC family integral membrane protein
DSM110093_RS07990	COG0488	(ABC) transporter
DSM110093_RS07995	COG0105	UTP biosynthetic process
DSM110093_RS08025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DSM110093_RS08030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DSM110093_RS08035	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DSM110093_RS08045	COG2166	iron-sulfur cluster assembly
DSM110093_RS08055	COG5012	cobalamin binding
DSM110093_RS08065	COG1410	methionine synthase
DSM110093_RS08065	COG0646	methionine synthase
DSM110093_RS08075	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DSM110093_RS08080	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM110093_RS08085	COG0047	phosphoribosylformylglycinamidine synthase activity
DSM110093_RS08095	COG2204	response regulator
DSM110093_RS08105	COG1530	ribonuclease E activity
DSM110093_RS08110	COG0425	Belongs to the sulfur carrier protein TusA family
DSM110093_RS08115	COG0785	Cytochrome C biogenesis protein
DSM110093_RS08130	COG3588	fructose-bisphosphate aldolase
DSM110093_RS08150	COG0114	fumarate hydratase activity
DSM110093_RS08160	COG2059	Chromate
DSM110093_RS08170	COG2186	Transcriptional regulator
DSM110093_RS08190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM110093_RS08195	COG0604	alcohol dehydrogenase
DSM110093_RS08205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSM110093_RS08210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DSM110093_RS08215	COG0415	Belongs to the DNA photolyase family
DSM110093_RS08220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSM110093_RS08230	COG0494	nUDIX hydrolase
DSM110093_RS08240	COG3264	Mechanosensitive ion channel
DSM110093_RS08240	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DSM110093_RS08260	COG1376	ErfK ybiS ycfS ynhG family protein
DSM110093_RS08280	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM110093_RS08285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DSM110093_RS08300	COG0433	COG0433 Predicted ATPase
DSM110093_RS08335	COG2133	pyrroloquinoline quinone binding
DSM110093_RS08345	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DSM110093_RS08355	COG1561	YicC-like family, N-terminal region
DSM110093_RS08360	COG0194	GDP metabolic process
DSM110093_RS08380	COG0573	inorganic phosphate transmembrane transporter activity
DSM110093_RS08390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DSM110093_RS08400	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS08410	COG3547	Transposase (IS116 IS110 IS902 family)
DSM110093_RS08420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DSM110093_RS08425	COG2197	response regulator
DSM110093_RS08430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DSM110093_RS08435	COG0052	Belongs to the universal ribosomal protein uS2 family
DSM110093_RS08460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DSM110093_RS08465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DSM110093_RS08470	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DSM110093_RS08480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DSM110093_RS08485	COG3743	rRNA binding
DSM110093_RS08485	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM110093_RS08535	COG0702	epimerase
DSM110093_RS08560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DSM110093_RS08565	COG0583	DNA-binding transcription factor activity
DSM110093_RS08570	COG2205	protein histidine kinase activity
DSM110093_RS08590	COG2828	Protein conserved in bacteria
DSM110093_RS08615	COG1802	Transcriptional regulator
DSM110093_RS08630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM110093_RS08650	COG0259	pyridoxamine-phosphate oxidase activity
DSM110093_RS08655	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DSM110093_RS08660	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DSM110093_RS08675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DSM110093_RS08695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM110093_RS08700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DSM110093_RS08710	COG0315	cyclic pyranopterin monophosphate synthase activity
DSM110093_RS08715	COG0303	'Molybdopterin
DSM110093_RS08720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DSM110093_RS08725	COG0658	competence protein
DSM110093_RS08725	COG2333	competence protein COMEC
DSM110093_RS08730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM110093_RS08735	COG0372	Belongs to the citrate synthase family
DSM110093_RS08745	COG1024	Enoyl-CoA hydratase
DSM110093_RS08750	COG3088	subunit of a heme lyase
DSM110093_RS08755	COG1138	Cytochrome C-type biogenesis protein
DSM110093_RS08770	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DSM110093_RS08775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DSM110093_RS08780	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DSM110093_RS08800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM110093_RS08845	COG0418	dihydroorotase activity
DSM110093_RS08850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DSM110093_RS08855	COG0305	Participates in initiation and elongation during chromosome replication
DSM110093_RS08875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DSM110093_RS08895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DSM110093_RS08905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DSM110093_RS08910	COG2885	chlorophyll binding
DSM110093_RS08935	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DSM110093_RS08935	COG3608	succinylglutamate desuccinylase aspartoacylase
DSM110093_RS08950	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DSM110093_RS08955	COG0698	ribose 5-phosphate isomerase
DSM110093_RS08975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DSM110093_RS08980	COG2354	Protein conserved in bacteria
DSM110093_RS09000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DSM110093_RS09020	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DSM110093_RS09025	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS09040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DSM110093_RS09050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM110093_RS09060	COG2814	Major facilitator Superfamily
DSM110093_RS09065	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DSM110093_RS09075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSM110093_RS09080	COG2833	Protein of unknown function (DUF455)
DSM110093_RS09085	COG0739	heme binding
DSM110093_RS09105	COG0126	phosphoglycerate kinase activity
DSM110093_RS09110	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DSM110093_RS09115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DSM110093_RS09125	COG0022	dehydrogenase e1 component
DSM110093_RS09125	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM110093_RS09130	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM110093_RS09210	COG4695	Portal protein
DSM110093_RS09220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DSM110093_RS09225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM110093_RS09235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DSM110093_RS09255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DSM110093_RS09260	COG0360	Binds together with S18 to 16S ribosomal RNA
DSM110093_RS09265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DSM110093_RS09270	COG0359	binds to the 23S rRNA
DSM110093_RS09280	COG0739	heme binding
DSM110093_RS09280	COG0741	lytic transglycosylase activity
DSM110093_RS09280	COG1196	nuclear chromosome segregation
DSM110093_RS09285	COG0737	Belongs to the 5'-nucleotidase family
DSM110093_RS09290	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSM110093_RS09300	COG3750	Belongs to the UPF0335 family
DSM110093_RS09315	COG5002	protein histidine kinase activity
DSM110093_RS09330	COG1396	sequence-specific DNA binding
DSM110093_RS09330	COG3800	Transcriptional regulator
DSM110093_RS09355	COG0410	ABC transporter
DSM110093_RS09365	COG0439	Biotin carboxylase
DSM110093_RS09370	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DSM110093_RS09395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DSM110093_RS09400	COG0740	serine-type endopeptidase activity
DSM110093_RS09410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DSM110093_RS09415	COG0737	Belongs to the 5'-nucleotidase family
DSM110093_RS09420	COG3258	Cytochrome c
DSM110093_RS09445	COG0785	Cytochrome C biogenesis protein
DSM110093_RS09460	COG2391	methyltransferase activity
DSM110093_RS09475	COG1121	(ABC) transporter
DSM110093_RS09480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSM110093_RS09485	COG0251	oxidation-reduction process
DSM110093_RS09495	COG3483	tryptophan 2,3-dioxygenase activity
DSM110093_RS09505	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS09510	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM110093_RS09510	COG1024	Enoyl-CoA hydratase
DSM110093_RS09535	COG1846	Transcriptional regulator
DSM110093_RS09560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DSM110093_RS09580	COG4175	Glycine betaine
DSM110093_RS09580	COG3448	diguanylate cyclase activity
DSM110093_RS09600	COG1320	monovalent cation:proton antiporter activity
DSM110093_RS09605	COG2212	antiporter activity
DSM110093_RS09610	COG1863	multisubunit Na H antiporter MnhE subunit
DSM110093_RS09615	COG0651	ATP synthesis coupled electron transport
DSM110093_RS09620	COG1006	Multisubunit Na H antiporter MnhC subunit
DSM110093_RS09625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DSM110093_RS09625	COG2111	Na H antiporter
DSM110093_RS09630	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110093_RS09645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS09655	COG1573	uracil-dna glycosylase
DSM110093_RS09675	COG0587	DNA-directed DNA polymerase activity
DSM110093_RS09680	COG0351	phosphomethylpyrimidine kinase
DSM110093_RS09695	COG2022	thiamine diphosphate biosynthetic process
DSM110093_RS09705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSM110093_RS09710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM110093_RS09715	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DSM110093_RS09720	COG1116	anion transmembrane transporter activity
DSM110093_RS09725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM110093_RS09755	COG3436	PFAM IS66 Orf2 family protein
DSM110093_RS09760	COG2433	Pfam Transposase IS66
DSM110093_RS09785	COG1686	Belongs to the peptidase S11 family
DSM110093_RS09790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DSM110093_RS09800	COG0084	hydrolase, TatD family'
DSM110093_RS09805	COG1234	tRNA 3'-trailer cleavage
DSM110093_RS09865	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSM110093_RS09875	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DSM110093_RS09875	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DSM110093_RS09920	COG1295	ribonuclease BN
DSM110093_RS09925	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DSM110093_RS09950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSM110093_RS09955	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DSM110093_RS09955	COG2010	Cytochrome c
DSM110093_RS09970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DSM110093_RS09995	COG0655	NAD(P)H dehydrogenase (quinone) activity
DSM110093_RS10000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM110093_RS10010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM110093_RS10015	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM110093_RS10020	COG4133	protoheme IX ABC transporter activity
DSM110093_RS10025	COG3737	Protein of unknown function (DUF498/DUF598)
DSM110093_RS10035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM110093_RS10040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM110093_RS10045	COG1862	Preprotein translocase
DSM110093_RS10050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DSM110093_RS10060	COG1160	GTP binding
DSM110093_RS10065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM110093_RS10085	COG5265	(ABC) transporter
DSM110093_RS10100	COG2962	Rard protein
DSM110093_RS10125	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM110093_RS10125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM110093_RS10140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110093_RS10145	COG4235	cytochrome complex assembly
DSM110093_RS10150	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DSM110093_RS10165	COG0730	response to heat
DSM110093_RS10170	COG2814	Major facilitator Superfamily
DSM110093_RS10175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSM110093_RS10185	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS10195	COG1175	transmembrane transport
DSM110093_RS10200	COG0395	ABC-type sugar transport system, permease component
DSM110093_RS10205	COG3842	ATPase activity
DSM110093_RS10215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DSM110093_RS10220	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM110093_RS10245	COG4191	Histidine kinase
DSM110093_RS10245	COG0784	Response regulator, receiver
DSM110093_RS10260	COG0628	permease
DSM110093_RS10280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM110093_RS10305	COG0729	surface antigen
DSM110093_RS10320	COG0321	lipoyl(octanoyl) transferase activity
DSM110093_RS10345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSM110093_RS10365	COG2873	o-acetylhomoserine
DSM110093_RS10370	COG2968	Membrane
DSM110093_RS10390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSM110093_RS10390	COG0475	glutathione-regulated potassium exporter activity
DSM110093_RS10395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DSM110093_RS10400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DSM110093_RS10405	COG1329	Transcriptional regulator
DSM110093_RS10410	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DSM110093_RS10415	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DSM110093_RS10435	COG2267	carboxylic ester hydrolase activity
DSM110093_RS10445	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DSM110093_RS10445	COG1793	dna ligase
DSM110093_RS10455	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DSM110093_RS10480	COG0564	pseudouridine synthase activity
DSM110093_RS10490	COG0483	inositol monophosphate 1-phosphatase activity
DSM110093_RS10495	COG2130	NADP-dependent
DSM110093_RS10500	COG0583	DNA-binding transcription factor activity
DSM110093_RS10550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM110093_RS10555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DSM110093_RS10560	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM110093_RS10560	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM110093_RS10585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM110093_RS10585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM110093_RS10590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DSM110093_RS10595	COG4221	oxidoreductase activity
DSM110093_RS10600	COG0432	Pfam Uncharacterised protein family UPF0047
DSM110093_RS10615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DSM110093_RS10620	COG0358	DNA primase activity
DSM110093_RS10635	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM110093_RS10635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM110093_RS10645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110093_RS10650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DSM110093_RS10715	COG0667	Aldo Keto reductase
DSM110093_RS10725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM110093_RS10735	COG2198	Histidine kinase
DSM110093_RS10735	COG5002	protein histidine kinase activity
DSM110093_RS10735	COG0784	Response regulator, receiver
DSM110093_RS10745	COG1522	sequence-specific DNA binding
DSM110093_RS10755	COG1473	amidohydrolase
DSM110093_RS10780	COG0019	diaminopimelate decarboxylase activity
DSM110093_RS10790	COG0525	valine-tRNA ligase activity
DSM110093_RS10800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM110093_RS10805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSM110093_RS10810	COG1132	(ABC) transporter
DSM110093_RS10820	COG0354	folic acid binding
DSM110093_RS10825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DSM110093_RS10840	COG1492	cobalamin metabolic process
DSM110093_RS10850	COG1522	sequence-specific DNA binding
DSM110093_RS10865	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS10880	COG0131	Imidazoleglycerol-phosphate dehydratase
DSM110093_RS10885	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DSM110093_RS10895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DSM110093_RS10900	COG0107	imidazoleglycerol-phosphate synthase activity
DSM110093_RS10905	COG0140	phosphoribosyl-ATP diphosphatase activity
DSM110093_RS10910	COG1832	CoA-binding protein
DSM110093_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS10925	COG1946	Acyl-CoA thioesterase
DSM110093_RS10990	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DSM110093_RS10995	COG1530	ribonuclease E activity
DSM110093_RS11000	COG0424	maF-like protein
DSM110093_RS11005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DSM110093_RS11010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSM110093_RS11025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSM110093_RS11030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DSM110093_RS11035	COG1183	phosphatidylcholine synthase activity
DSM110093_RS11045	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DSM110093_RS11060	COG1216	Glycosyl transferase, family 2
DSM110093_RS11070	COG0438	transferase activity, transferring glycosyl groups
DSM110093_RS11080	COG3768	UPF0283 membrane protein
DSM110093_RS11090	COG3106	COG3106 Predicted ATPase
DSM110093_RS11095	COG0101	tRNA pseudouridine synthase activity
DSM110093_RS11100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DSM110093_RS11110	COG0306	phosphate transporter
DSM110093_RS11125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSM110093_RS11175	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DSM110093_RS11180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSM110093_RS11185	COG0135	phosphoribosylanthranilate isomerase activity
DSM110093_RS11195	COG0776	regulation of translation
DSM110093_RS11200	COG0539	negative regulation of cytoplasmic translation
DSM110093_RS11205	COG2201	protein-glutamate methylesterase activity
DSM110093_RS11210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DSM110093_RS11215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DSM110093_RS11225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DSM110093_RS11230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DSM110093_RS11235	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DSM110093_RS11240	COG1253	flavin adenine dinucleotide binding
DSM110093_RS11245	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DSM110093_RS11250	COG1702	phosphate starvation-inducible protein PhoH
DSM110093_RS11270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM110093_RS11285	COG1183	phosphatidylcholine synthase activity
DSM110093_RS11295	COG0735	belongs to the Fur family
DSM110093_RS11300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM110093_RS11305	COG0702	epimerase
DSM110093_RS11310	COG1012	belongs to the aldehyde dehydrogenase family
DSM110093_RS11315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM110093_RS11320	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DSM110093_RS11330	COG1047	Peptidyl-prolyl cis-trans
DSM110093_RS11350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM110093_RS11375	COG0837	glucose binding
DSM110093_RS11390	COG1228	amidohydrolase
DSM110093_RS11395	COG2986	histidine ammonia-lyase
DSM110093_RS11405	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DSM110093_RS11450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DSM110093_RS11455	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DSM110093_RS11460	COG3639	organic phosphonate transmembrane transporter activity
DSM110093_RS11465	COG3639	organic phosphonate transmembrane transporter activity
DSM110093_RS11475	COG2188	Transcriptional regulator
DSM110093_RS11480	COG3624	Phosphonate C-P lyase system protein PhnG
DSM110093_RS11485	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
DSM110093_RS11490	COG3626	phosphonate metabolism
DSM110093_RS11495	COG3627	carbon phosphorus lyase activity
DSM110093_RS11500	COG4107	phosphonate C-P lyase system protein PhnK
DSM110093_RS11505	COG4778	phosphonate C-P lyase system protein PhnL
DSM110093_RS11515	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DSM110093_RS11520	COG3454	Phosphonate metabolism
DSM110093_RS11545	COG1177	transmembrane transport
DSM110093_RS11550	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM110093_RS11555	COG3842	ATPase activity
DSM110093_RS11560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DSM110093_RS11565	COG0154	amidase activity
DSM110093_RS11705	COG2259	Doxx family
DSM110093_RS11730	COG0012	GTP binding
DSM110093_RS11740	COG0159	tryptophan synthase activity
DSM110093_RS11745	COG1304	FMN binding
DSM110093_RS11755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DSM110093_RS11760	COG0193	aminoacyl-tRNA hydrolase activity
DSM110093_RS11765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DSM110093_RS11795	COG0133	tryptophan synthase activity
DSM110093_RS11805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM110093_RS11815	COG0583	DNA-binding transcription factor activity
DSM110093_RS11825	COG1272	protein, Hemolysin III
DSM110093_RS11855	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DSM110093_RS11860	COG1214	PFAM Peptidase M22, glycoprotease
DSM110093_RS11870	COG1744	ABC transporter substrate-binding protein PnrA-like
DSM110093_RS11875	COG3845	ABC transporter
DSM110093_RS11880	COG4603	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS11885	COG1079	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS11890	COG0730	response to heat
DSM110093_RS11910	COG0604	alcohol dehydrogenase
DSM110093_RS11915	COG2937	Belongs to the GPAT DAPAT family
DSM110093_RS11920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM110093_RS11920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSM110093_RS11930	COG0813	purine-nucleoside phosphorylase activity
DSM110093_RS11965	COG0039	L-malate dehydrogenase activity
DSM110093_RS11980	COG2301	Belongs to the HpcH HpaI aldolase family
DSM110093_RS11995	COG2030	dehydratase
DSM110093_RS12000	COG0045	succinate-CoA ligase (ADP-forming) activity
DSM110093_RS12035	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM110093_RS12070	COG2884	Cell division ATP-binding protein ftsE
DSM110093_RS12085	COG0019	diaminopimelate decarboxylase activity
DSM110093_RS12105	COG0165	Argininosuccinate lyase
DSM110093_RS12110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM110093_RS12130	COG0402	S-adenosylhomocysteine deaminase activity
DSM110093_RS12135	COG1079	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS12140	COG4603	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS12145	COG3845	ABC transporter
DSM110093_RS12155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM110093_RS12175	COG0811	peptide transport
DSM110093_RS12190	COG0640	Transcriptional regulator
DSM110093_RS12205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM110093_RS12205	COG3453	Protein conserved in bacteria
DSM110093_RS12220	COG2951	lytic endotransglycosylase activity
DSM110093_RS12235	COG1558	bacterial-type flagellum-dependent cell motility
DSM110093_RS12240	COG1677	Flagellar hook-basal body complex protein FliE
DSM110093_RS12245	COG1987	bacterial-type flagellum assembly
DSM110093_RS12255	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DSM110093_RS12265	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DSM110093_RS12290	COG1766	The M ring may be actively involved in energy transduction
DSM110093_RS12300	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM110093_RS12305	COG1338	Plays a role in the flagellum-specific transport system
DSM110093_RS12310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM110093_RS12320	COG5443	negative regulation of bacterial-type flagellum assembly
DSM110093_RS12325	COG5442	Flagellar protein FlaF
DSM110093_RS12330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSM110093_RS12345	COG1706	bacterial-type flagellum-dependent cell motility
DSM110093_RS12360	COG1749	Flagellar hook protein flgE
DSM110093_RS12370	COG4786	Flagellar basal body rod
DSM110093_RS12375	COG4786	Flagellar basal body rod
DSM110093_RS12385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DSM110093_RS12410	COG1360	Flagellar Motor Protein
DSM110093_RS12425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DSM110093_RS12460	COG1802	Transcriptional regulator
DSM110093_RS12465	COG0174	glutamine synthetase
DSM110093_RS12470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110093_RS12480	COG1174	glycine betaine transport
DSM110093_RS12485	COG1125	glycine betaine transport
DSM110093_RS12490	COG1174	glycine betaine transport
DSM110093_RS12495	COG1732	Glycine betaine
DSM110093_RS12530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM110093_RS12540	COG3321	synthase
DSM110093_RS12540	COG0604	alcohol dehydrogenase
DSM110093_RS12545	COG0583	DNA-binding transcription factor activity
DSM110093_RS12555	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS12565	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS12595	COG3842	ATPase activity
DSM110093_RS12600	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM110093_RS12605	COG1177	transmembrane transport
DSM110093_RS12630	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS12640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS12645	COG0601	transmembrane transport
DSM110093_RS12665	COG0028	Belongs to the TPP enzyme family
DSM110093_RS12670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM110093_RS12680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSM110093_RS12690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS12695	COG0601	transmembrane transport
DSM110093_RS12700	COG0747	negative chemotaxis
DSM110093_RS12705	COG1162	GTPase activity
DSM110093_RS12720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM110093_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS12730	COG2084	Dehydrogenase
DSM110093_RS12735	COG0129	dihydroxy-acid dehydratase activity
DSM110093_RS12750	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM110093_RS12775	COG1172	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS12780	COG1079	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS12790	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
DSM110093_RS12795	COG0410	ABC transporter
DSM110093_RS12840	COG2207	Transcriptional regulator
DSM110093_RS12855	COG2814	Major facilitator Superfamily
DSM110093_RS12885	COG4771	TonB-dependent receptor
DSM110093_RS12890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM110093_RS12895	COG0583	DNA-binding transcription factor activity
DSM110093_RS12900	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DSM110093_RS12905	COG0523	cobalamin synthesis protein
DSM110093_RS12925	COG0523	cobalamin synthesis protein
DSM110093_RS12965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM110093_RS12970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM110093_RS12985	COG2814	Major facilitator Superfamily
DSM110093_RS12990	COG3958	Transketolase
DSM110093_RS12995	COG3959	Transketolase, thiamine diphosphate binding domain
DSM110093_RS13010	COG0444	Belongs to the ABC transporter superfamily
DSM110093_RS13015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS13020	COG0601	transmembrane transport
DSM110093_RS13025	COG0747	negative chemotaxis
DSM110093_RS13065	COG3547	Transposase (IS116 IS110 IS902 family)
DSM110093_RS13085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS13105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110093_RS13115	COG0673	inositol 2-dehydrogenase activity
DSM110093_RS13150	COG1012	belongs to the aldehyde dehydrogenase family
DSM110093_RS13160	COG2301	Belongs to the HpcH HpaI aldolase family
DSM110093_RS13175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS13225	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DSM110093_RS13230	COG0583	DNA-binding transcription factor activity
DSM110093_RS13235	COG3781	membrane
DSM110093_RS13245	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM110093_RS13245	COG1902	pentaerythritol trinitrate reductase activity
DSM110093_RS13255	COG2358	TRAP transporter, solute receptor (TAXI family
DSM110093_RS13260	COG1802	Transcriptional regulator
DSM110093_RS13270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DSM110093_RS13310	COG1230	cation diffusion facilitator family transporter
DSM110093_RS13325	COG0789	Transcriptional regulator
DSM110093_RS13335	COG3920	Histidine kinase
DSM110093_RS13360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM110093_RS13375	COG2433	Pfam Transposase IS66
DSM110093_RS13380	COG3436	PFAM IS66 Orf2 family protein
DSM110093_RS13390	COG0235	Class ii aldolase
DSM110093_RS13395	COG3395	kinase activity
DSM110093_RS13400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110093_RS13405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM110093_RS13415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS13425	COG1802	Transcriptional regulator
DSM110093_RS13430	COG3618	amidohydrolase
DSM110093_RS13435	COG3181	Tripartite tricarboxylate transporter family receptor
DSM110093_RS13475	COG4175	Glycine betaine
DSM110093_RS13475	COG3448	diguanylate cyclase activity
DSM110093_RS13480	COG4176	ABC-type proline glycine betaine transport system permease component
DSM110093_RS13485	COG0154	amidase activity
DSM110093_RS13500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM110093_RS13520	COG0653	protein targeting
DSM110093_RS13540	COG2207	Transcriptional regulator
DSM110093_RS13545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS13555	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM110093_RS13555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110093_RS13560	COG3938	Belongs to the proline racemase family
DSM110093_RS13575	COG1522	sequence-specific DNA binding
DSM110093_RS13580	COG0384	phenazine biosynthesis protein PhzF
DSM110093_RS13590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM110093_RS13595	COG0569	domain protein
DSM110093_RS13605	COG0300	oxidoreductase activity
DSM110093_RS13635	COG0583	DNA-binding transcription factor activity
DSM110093_RS13650	COG0251	oxidation-reduction process
DSM110093_RS13665	COG3457	Alanine racemase
DSM110093_RS13700	COG0189	ligase activity
DSM110093_RS13700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSM110093_RS13705	COG0189	ligase activity
DSM110093_RS13705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSM110093_RS13710	COG4242	Belongs to the peptidase S51 family
DSM110093_RS13715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DSM110093_RS13720	COG3119	arylsulfatase activity
DSM110093_RS13725	COG4176	ABC-type proline glycine betaine transport system permease component
DSM110093_RS13730	COG4175	Glycine betaine
DSM110093_RS13730	COG3448	diguanylate cyclase activity
DSM110093_RS13735	COG2113	Glycine betaine
DSM110093_RS13750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM110093_RS13760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DSM110093_RS13765	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DSM110093_RS13770	COG0124	histidyl-tRNA synthetase
DSM110093_RS13795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM110093_RS13805	COG3845	ABC transporter
DSM110093_RS13810	COG4603	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS13815	COG1079	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS13830	COG0667	Aldo Keto reductase
DSM110093_RS13840	COG3757	hydrolase, family 25
DSM110093_RS13855	COG0277	FAD linked oxidase domain protein
DSM110093_RS13870	COG0604	alcohol dehydrogenase
DSM110093_RS13885	COG3328	transposase activity
DSM110093_RS13920	COG4607	ABC-type enterochelin transport system periplasmic component
DSM110093_RS13925	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM110093_RS13930	COG4605	iron ion homeostasis
DSM110093_RS13935	COG4604	ABC transporter, ATP-binding protein
DSM110093_RS13965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM110093_RS13995	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110093_RS14000	COG1024	Enoyl-CoA hydratase
DSM110093_RS14010	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS14015	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS14020	COG0183	Belongs to the thiolase family
DSM110093_RS14025	COG1024	Enoyl-CoA hydratase
DSM110093_RS14025	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM110093_RS14050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DSM110093_RS14055	COG3246	L-lysine catabolic process to acetate
DSM110093_RS14060	COG0481	GTPase activity
DSM110093_RS14085	COG5328	Belongs to the UPF0262 family
DSM110093_RS14090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DSM110093_RS14105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DSM110093_RS14120	COG2032	superoxide dismutase activity
DSM110093_RS14135	COG5002	protein histidine kinase activity
DSM110093_RS14135	COG2198	Histidine kinase
DSM110093_RS14135	COG0784	Response regulator, receiver
DSM110093_RS14140	COG4221	oxidoreductase activity
DSM110093_RS14145	COG2197	response regulator
DSM110093_RS14155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DSM110093_RS14190	COG1609	Transcriptional regulator
DSM110093_RS14195	COG0800	Aldolase
DSM110093_RS14200	COG0129	dihydroxy-acid dehydratase activity
DSM110093_RS14205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DSM110093_RS14235	COG0697	spore germination
DSM110093_RS14250	COG0154	amidase activity
DSM110093_RS14265	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM110093_RS14270	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS14275	COG2207	Transcriptional regulator
DSM110093_RS14285	COG3547	Transposase (IS116 IS110 IS902 family)
DSM110093_RS14295	COG3547	Transposase (IS116 IS110 IS902 family)
DSM110093_RS14320	COG0405	Gamma-glutamyltransferase
DSM110093_RS14330	COG0667	Aldo Keto reductase
DSM110093_RS14375	COG3395	kinase activity
DSM110093_RS14380	COG0235	Class ii aldolase
DSM110093_RS14385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSM110093_RS14390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110093_RS14400	COG0583	DNA-binding transcription factor activity
DSM110093_RS14450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM110093_RS14455	COG1024	Enoyl-CoA hydratase
DSM110093_RS14460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110093_RS14470	COG1960	acyl-CoA dehydrogenase activity
DSM110093_RS14485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DSM110093_RS14535	COG0402	S-adenosylhomocysteine deaminase activity
DSM110093_RS14540	COG0210	DNA helicase
DSM110093_RS14590	COG0556	nucleotide-excision repair
DSM110093_RS14625	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DSM110093_RS14645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DSM110093_RS14650	COG1115	amino acid carrier protein
DSM110093_RS14660	COG0488	(ABC) transporter
DSM110093_RS14670	COG1278	Cold shock
DSM110093_RS14675	COG1376	ErfK ybiS ycfS ynhG family protein
DSM110093_RS14685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM110093_RS14690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM110093_RS14710	COG1309	transcriptional regulator
DSM110093_RS14720	COG0493	'glutamate synthase
DSM110093_RS14725	COG1278	Cold shock
DSM110093_RS14735	COG4181	ATPase activity
DSM110093_RS14740	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DSM110093_RS14745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM110093_RS14745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM110093_RS14750	COG0509	glycine decarboxylation via glycine cleavage system
DSM110093_RS14755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM110093_RS14765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM110093_RS14790	COG3046	protein related to deoxyribodipyrimidine photolyase
DSM110093_RS14800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM110093_RS14825	COG0768	penicillin binding
DSM110093_RS14830	COG0772	Belongs to the SEDS family
DSM110093_RS14835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM110093_RS14845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSM110093_RS14850	COG0756	dUTP diphosphatase activity
DSM110093_RS14855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DSM110093_RS14880	COG0606	chelatase, subunit chli
DSM110093_RS14890	COG0189	ligase activity
DSM110093_RS14895	COG0792	nuclease activity
DSM110093_RS14900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DSM110093_RS14910	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DSM110093_RS14930	COG0180	Tryptophanyl-tRNA synthetase
DSM110093_RS14940	COG0778	Nitroreductase
DSM110093_RS14955	COG0346	lactoylglutathione lyase activity
DSM110093_RS14960	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS14990	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DSM110093_RS14995	COG0438	transferase activity, transferring glycosyl groups
DSM110093_RS15060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DSM110093_RS15075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSM110093_RS15085	COG0300	oxidoreductase activity
DSM110093_RS15095	COG2096	Adenosyltransferase
DSM110093_RS15115	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM110093_RS15125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM110093_RS15135	COG1660	Displays ATPase and GTPase activities
DSM110093_RS15140	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DSM110093_RS15145	COG2205	protein histidine kinase activity
DSM110093_RS15150	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS15155	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DSM110093_RS15160	COG0583	DNA-binding transcription factor activity
DSM110093_RS15165	COG1396	sequence-specific DNA binding
DSM110093_RS15180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DSM110093_RS15190	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM110093_RS15195	COG0356	it plays a direct role in the translocation of protons across the membrane
DSM110093_RS15220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DSM110093_RS15225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DSM110093_RS15235	COG0228	four-way junction DNA binding
DSM110093_RS15240	COG0778	Nitroreductase
DSM110093_RS15250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DSM110093_RS15260	COG0336	Belongs to the RNA methyltransferase TrmD family
DSM110093_RS15270	COG0335	large ribosomal subunit rRNA binding
DSM110093_RS15275	COG0254	rRNA binding
DSM110093_RS15285	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM110093_RS15285	COG0489	protein tyrosine kinase activity
DSM110093_RS15300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DSM110093_RS15305	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM110093_RS15320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM110093_RS15330	COG0747	negative chemotaxis
DSM110093_RS15340	COG0673	inositol 2-dehydrogenase activity
DSM110093_RS15355	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS15365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DSM110093_RS15375	COG1686	Belongs to the peptidase S11 family
DSM110093_RS15380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM110093_RS15385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM110093_RS15400	COG1802	Transcriptional regulator
DSM110093_RS15405	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM110093_RS15435	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DSM110093_RS15445	COG0384	phenazine biosynthesis protein PhzF
DSM110093_RS15450	COG1522	sequence-specific DNA binding
DSM110093_RS15495	COG1204	response to ionizing radiation
DSM110093_RS15515	COG3639	organic phosphonate transmembrane transporter activity
DSM110093_RS15520	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DSM110093_RS15530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DSM110093_RS15535	COG0573	inorganic phosphate transmembrane transporter activity
DSM110093_RS15540	COG0581	inorganic phosphate transmembrane transporter activity
DSM110093_RS15550	COG0704	Plays a role in the regulation of phosphate uptake
DSM110093_RS15555	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS15565	COG4172	Belongs to the ABC transporter superfamily
DSM110093_RS15570	COG4239	(ABC) transporter, permease
DSM110093_RS15575	COG4174	ABC transporter (Permease)
DSM110093_RS15580	COG4166	transmembrane transport
DSM110093_RS15585	COG2267	carboxylic ester hydrolase activity
DSM110093_RS15605	COG2816	NAD+ diphosphatase activity
DSM110093_RS15610	COG0737	Belongs to the 5'-nucleotidase family
DSM110093_RS15620	COG2321	neutral zinc metallopeptidase
DSM110093_RS15630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DSM110093_RS15635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DSM110093_RS15640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DSM110093_RS15665	COG3321	synthase
DSM110093_RS15665	COG0604	alcohol dehydrogenase
DSM110093_RS15665	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS15670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM110093_RS15675	COG0183	Belongs to the thiolase family
DSM110093_RS15680	COG1268	BioY protein
DSM110093_RS15685	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DSM110093_RS15690	COG1122	ATPase activity
DSM110093_RS15700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DSM110093_RS15705	COG1522	sequence-specific DNA binding
DSM110093_RS15710	COG0686	Belongs to the AlaDH PNT family
DSM110093_RS15715	COG1970	mechanosensitive ion channel activity
DSM110093_RS15730	COG0072	phenylalanine-tRNA ligase activity
DSM110093_RS15730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM110093_RS15740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DSM110093_RS15760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DSM110093_RS15765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DSM110093_RS15775	COG0469	pyruvate kinase activity
DSM110093_RS15805	COG4948	Mandelate Racemase Muconate Lactonizing
DSM110093_RS15820	COG0825	malonyl-CoA metabolic process
DSM110093_RS15840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DSM110093_RS15840	COG0512	Glutamine amidotransferase of anthranilate synthase
DSM110093_RS15875	COG1381	Involved in DNA repair and RecF pathway recombination
DSM110093_RS15885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DSM110093_RS15890	COG0571	ribonuclease III activity
DSM110093_RS15895	COG0681	Belongs to the peptidase S26 family
DSM110093_RS15900	COG0736	holo-[acyl-carrier-protein] synthase activity
DSM110093_RS15910	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DSM110093_RS15920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSM110093_RS15925	COG1758	RNA polymerase activity
DSM110093_RS15930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DSM110093_RS15945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DSM110093_RS15950	COG0328	RNA-DNA hybrid ribonuclease activity
DSM110093_RS15955	COG2860	membrane
DSM110093_RS15960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM110093_RS15965	COG0242	peptide deformylase activity
DSM110093_RS15975	COG0242	peptide deformylase activity
DSM110093_RS15980	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DSM110093_RS15990	COG0435	Glutathione S-transferase
DSM110093_RS16000	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DSM110093_RS16015	COG0251	oxidation-reduction process
DSM110093_RS16020	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DSM110093_RS16035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM110093_RS16045	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DSM110093_RS16050	COG2971	BadF BadG BcrA BcrD
DSM110093_RS16055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM110093_RS16060	COG0243	molybdopterin cofactor binding
DSM110093_RS16065	COG0437	4 iron, 4 sulfur cluster binding
DSM110093_RS16075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM110093_RS16080	COG0741	lytic transglycosylase activity
DSM110093_RS16090	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DSM110093_RS16090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110093_RS16100	COG2885	chlorophyll binding
DSM110093_RS16105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSM110093_RS16110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DSM110093_RS16115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM110093_RS16130	COG1051	belongs to the nudix hydrolase family
DSM110093_RS16135	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM110093_RS16135	COG1902	pentaerythritol trinitrate reductase activity
DSM110093_RS16145	COG0583	DNA-binding transcription factor activity
DSM110093_RS16150	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DSM110093_RS16165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DSM110093_RS16175	COG0129	dihydroxy-acid dehydratase activity
DSM110093_RS16200	COG0793	Belongs to the peptidase S41A family
DSM110093_RS16210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DSM110093_RS16220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM110093_RS16220	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM110093_RS16235	COG3622	Belongs to the hyi family
DSM110093_RS16245	COG0714	Associated with various cellular activities
DSM110093_RS16275	COG3022	response to hydroperoxide
DSM110093_RS16280	COG0514	ATP-dependent DNA helicase (RecQ)
DSM110093_RS16300	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
DSM110093_RS16335	COG1797	cobyrinic acid a,c-diamide synthase activity
DSM110093_RS16340	COG2875	Belongs to the precorrin methyltransferase family
DSM110093_RS16355	COG2099	Precorrin-6x reductase
DSM110093_RS16410	COG3920	Histidine kinase
DSM110093_RS16415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DSM110093_RS16420	COG1335	isochorismatase
DSM110093_RS16425	COG1054	Belongs to the UPF0176 family
DSM110093_RS16430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110093_RS16435	COG1177	transmembrane transport
DSM110093_RS16440	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM110093_RS16445	COG3842	ATPase activity
DSM110093_RS16455	COG1802	Transcriptional regulator
DSM110093_RS16465	COG2951	lytic endotransglycosylase activity
DSM110093_RS16470	COG0557	exoribonuclease II activity
DSM110093_RS16480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM110093_RS16495	COG2171	N-acyltransferase activity
DSM110093_RS16515	COG2205	protein histidine kinase activity
DSM110093_RS16515	COG0784	Response regulator, receiver
DSM110093_RS16515	COG2198	Histidine kinase
DSM110093_RS16520	COG5002	protein histidine kinase activity
DSM110093_RS16535	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS16540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM110093_RS16545	COG1012	belongs to the aldehyde dehydrogenase family
DSM110093_RS16550	COG1522	sequence-specific DNA binding
DSM110093_RS16555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM110093_RS16560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS16565	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM110093_RS16570	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110093_RS16575	COG0589	response to stress
DSM110093_RS16585	COG0006	proline dipeptidase activity
DSM110093_RS16590	COG3608	succinylglutamate desuccinylase aspartoacylase
DSM110093_RS16595	COG4608	Belongs to the ABC transporter superfamily
DSM110093_RS16600	COG0444	Belongs to the ABC transporter superfamily
DSM110093_RS16605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS16610	COG0601	transmembrane transport
DSM110093_RS16615	COG0006	proline dipeptidase activity
DSM110093_RS16620	COG0747	negative chemotaxis
DSM110093_RS16640	COG0444	Belongs to the ABC transporter superfamily
DSM110093_RS16645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS16655	COG0747	negative chemotaxis
DSM110093_RS16665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DSM110093_RS16670	COG1846	Transcriptional regulator
DSM110093_RS16675	COG0456	acetyltransferase
DSM110093_RS16680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DSM110093_RS16685	COG1917	Cupin 2, conserved barrel domain protein
DSM110093_RS16690	COG0527	aspartate kinase activity
DSM110093_RS16710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DSM110093_RS16715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM110093_RS16720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DSM110093_RS16725	COG1063	alcohol dehydrogenase
DSM110093_RS16730	COG0156	8-amino-7-oxononanoate synthase activity
DSM110093_RS16735	COG1396	sequence-specific DNA binding
DSM110093_RS16740	COG0183	Belongs to the thiolase family
DSM110093_RS16750	COG2226	methyltransferase
DSM110093_RS16755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DSM110093_RS16760	COG1024	Enoyl-CoA hydratase
DSM110093_RS16765	COG0268	Binds directly to 16S ribosomal RNA
DSM110093_RS16770	COG1192	Involved in chromosome partitioning
DSM110093_RS16775	COG1475	DNA binding
DSM110093_RS16795	COG3609	addiction module antidote protein, CC2985 family
DSM110093_RS16835	COG1346	cytolysis
DSM110093_RS16845	COG2188	Transcriptional regulator
DSM110093_RS16860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DSM110093_RS16875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DSM110093_RS16885	COG3547	Transposase (IS116 IS110 IS902 family)
DSM110093_RS16900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM110093_RS16910	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM110093_RS16915	COG4605	iron ion homeostasis
DSM110093_RS16920	COG4604	ABC transporter, ATP-binding protein
DSM110093_RS16925	COG4771	TonB-dependent receptor
DSM110093_RS16985	COG3181	Tripartite tricarboxylate transporter family receptor
DSM110093_RS17000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM110093_RS17010	COG2814	Major facilitator Superfamily
DSM110093_RS17025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSM110093_RS17030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DSM110093_RS17030	COG2010	Cytochrome c
DSM110093_RS17060	COG2010	Cytochrome c
DSM110093_RS17095	COG2010	Cytochrome c
DSM110093_RS17100	COG0348	domain, Protein
DSM110093_RS17130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM110093_RS17140	COG0784	Response regulator, receiver
DSM110093_RS17140	COG4191	Histidine kinase
DSM110093_RS17170	COG0784	Response regulator, receiver
DSM110093_RS17170	COG2205	protein histidine kinase activity
DSM110093_RS17170	COG2198	Histidine kinase
DSM110093_RS17175	COG3547	Transposase (IS116 IS110 IS902 family)
DSM110093_RS17210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM110093_RS17240	COG3609	addiction module antidote protein, CC2985 family
DSM110093_RS17250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DSM110093_RS17300	COG0784	Response regulator, receiver
DSM110093_RS17300	COG2198	Histidine kinase
DSM110093_RS17300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM110093_RS17300	COG2205	protein histidine kinase activity
DSM110093_RS17325	COG3850	Histidine kinase
DSM110093_RS17325	COG3437	response regulator, receiver
DSM110093_RS17325	COG2205	protein histidine kinase activity
DSM110093_RS17325	COG4999	Histidine kinase
DSM110093_RS17330	COG2205	protein histidine kinase activity
DSM110093_RS17330	COG0784	Response regulator, receiver
DSM110093_RS17340	COG3622	Belongs to the hyi family
DSM110093_RS17345	COG0129	dihydroxy-acid dehydratase activity
DSM110093_RS17350	COG2084	Dehydrogenase
DSM110093_RS17380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DSM110093_RS17390	COG0601	transmembrane transport
DSM110093_RS17405	COG0747	negative chemotaxis
DSM110093_RS17410	COG0024	Methionine aminopeptidase
DSM110093_RS17420	COG0500	methyltransferase
DSM110093_RS17425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DSM110093_RS17435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DSM110093_RS17455	COG0776	regulation of translation
DSM110093_RS17470	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS17515	COG4964	Belongs to the GSP D family
DSM110093_RS17585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM110093_RS17610	COG4372	Transposase
DSM110093_RS17640	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS17640	COG3321	synthase
DSM110093_RS17640	COG0604	alcohol dehydrogenase
DSM110093_RS17690	COG1132	(ABC) transporter
DSM110093_RS17710	COG0175	sulfate reduction
DSM110093_RS17725	COG0662	Cupin 2, conserved barrel domain protein
DSM110093_RS17725	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DSM110093_RS17770	COG0251	oxidation-reduction process
DSM110093_RS17785	COG3608	succinylglutamate desuccinylase aspartoacylase
DSM110093_RS17810	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS17825	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS17850	COG3620	sequence-specific DNA binding
DSM110093_RS17855	COG3550	peptidyl-serine autophosphorylation
DSM110093_RS17870	COG0174	glutamine synthetase
DSM110093_RS17875	COG4115	mRNA cleavage
DSM110093_RS17880	COG2161	toxin-antitoxin pair type II binding
DSM110093_RS17895	COG2337	Toxic component of a toxin-antitoxin (TA) module
DSM110093_RS17910	COG2826	transposase and inactivated derivatives, IS30 family
DSM110093_RS17945	COG3328	transposase activity
DSM110093_RS17970	COG1309	transcriptional regulator
DSM110093_RS17980	COG0583	DNA-binding transcription factor activity
DSM110093_RS17990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM110093_RS18005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110093_RS18030	COG3547	Transposase (IS116 IS110 IS902 family)
DSM110093_RS18040	COG0463	Glycosyl transferase, family 2
DSM110093_RS18055	COG0586	Pfam SNARE associated Golgi protein
DSM110093_RS18075	COG2814	Major facilitator Superfamily
DSM110093_RS18090	COG2353	YceI-like domain
DSM110093_RS18100	COG5002	protein histidine kinase activity
DSM110093_RS18110	COG1304	FMN binding
DSM110093_RS18115	COG3119	arylsulfatase activity
DSM110093_RS18140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DSM110093_RS18145	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DSM110093_RS18195	COG2010	Cytochrome c
DSM110093_RS18195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM110093_RS18210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM110093_RS18215	COG0569	domain protein
DSM110093_RS18230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM110093_RS18250	COG0673	inositol 2-dehydrogenase activity
DSM110093_RS18260	COG0246	Mannitol dehydrogenase
DSM110093_RS18265	COG1312	Catalyzes the dehydration of D-mannonate
DSM110093_RS18270	COG1904	glucuronate isomerase
DSM110093_RS18275	COG1802	Transcriptional regulator
DSM110093_RS18300	COG1192	Involved in chromosome partitioning
DSM110093_RS18305	COG1475	DNA binding
DSM110093_RS18315	COG3609	addiction module antidote protein, CC2985 family
DSM110093_RS18340	COG4166	transmembrane transport
DSM110093_RS18350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110093_RS18370	COG1414	Transcriptional regulator
DSM110093_RS18440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM110093_RS18470	COG3609	addiction module antidote protein, CC2985 family
DSM110093_RS18480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DSM110093_RS18530	COG2205	protein histidine kinase activity
DSM110093_RS18530	COG0784	Response regulator, receiver
DSM110093_RS18530	COG2198	Histidine kinase
DSM110093_RS18530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM110093_RS18555	COG2205	protein histidine kinase activity
DSM110093_RS18555	COG3437	response regulator, receiver
DSM110093_RS18555	COG3850	Histidine kinase
DSM110093_RS18555	COG4999	Histidine kinase
DSM110093_RS18560	COG0784	Response regulator, receiver
DSM110093_RS18560	COG2205	protein histidine kinase activity
DSM110093_RS18570	COG3622	Belongs to the hyi family
DSM110093_RS18575	COG0129	dihydroxy-acid dehydratase activity
DSM110093_RS18580	COG2084	Dehydrogenase
DSM110093_RS18610	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DSM110093_RS18620	COG0601	transmembrane transport
DSM110093_RS18635	COG0747	negative chemotaxis
DSM110093_RS18640	COG0024	Methionine aminopeptidase
DSM110093_RS18650	COG0500	methyltransferase
DSM110093_RS18655	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DSM110093_RS18665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DSM110093_RS18685	COG0776	regulation of translation
DSM110093_RS18700	COG0745	RESPONSE REGULATOR receiver
DSM110093_RS18745	COG4964	Belongs to the GSP D family
DSM110093_RS18815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM110093_RS18840	COG4372	Transposase
DSM110093_RS18870	COG0604	alcohol dehydrogenase
DSM110093_RS18870	COG3321	synthase
DSM110093_RS18870	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS18920	COG1132	(ABC) transporter
DSM110093_RS18940	COG0175	sulfate reduction
DSM110093_RS18955	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DSM110093_RS18955	COG0662	Cupin 2, conserved barrel domain protein
DSM110093_RS19000	COG0251	oxidation-reduction process
DSM110093_RS19015	COG3608	succinylglutamate desuccinylase aspartoacylase
DSM110093_RS19040	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS19055	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS19080	COG3620	sequence-specific DNA binding
DSM110093_RS19085	COG3550	peptidyl-serine autophosphorylation
DSM110093_RS19100	COG0174	glutamine synthetase
DSM110093_RS19105	COG4115	mRNA cleavage
DSM110093_RS19110	COG2161	toxin-antitoxin pair type II binding
DSM110093_RS19125	COG2337	Toxic component of a toxin-antitoxin (TA) module
DSM110093_RS19140	COG2826	transposase and inactivated derivatives, IS30 family
DSM110093_RS19165	COG0318	PFAM AMP-dependent synthetase and ligase
DSM110093_RS19180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS19185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM110093_RS19190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM110093_RS19190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110093_RS19195	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS19240	COG1091	dTDP-4-dehydrorhamnose reductase activity
DSM110093_RS19270	COG2826	transposase and inactivated derivatives, IS30 family
DSM110093_RS19315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DSM110093_RS19320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DSM110093_RS19325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM110093_RS19325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM110093_RS19330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM110093_RS19375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DSM110093_RS19380	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DSM110093_RS19395	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM110093_RS19405	COG1596	polysaccharide export
DSM110093_RS19410	COG0250	Participates in transcription elongation, termination and antitermination
DSM110093_RS19435	COG0489	protein tyrosine kinase activity
DSM110093_RS19435	COG3206	protein involved in exopolysaccharide biosynthesis
DSM110093_RS19500	COG1192	Involved in chromosome partitioning
DSM110093_RS19505	COG1475	DNA binding
DSM110093_RS19515	COG3852	Histidine kinase
DSM110093_RS19520	COG1363	Peptidase, m42
DSM110093_RS19535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS19570	COG4221	oxidoreductase activity
DSM110093_RS19575	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DSM110093_RS19580	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS19585	COG2084	Dehydrogenase
DSM110093_RS19590	COG1012	belongs to the aldehyde dehydrogenase family
DSM110093_RS19605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS19610	COG1011	Hydrolase
DSM110093_RS19620	COG3639	organic phosphonate transmembrane transporter activity
DSM110093_RS19635	COG2188	Transcriptional regulator
DSM110093_RS19640	COG0730	response to heat
DSM110093_RS19650	COG0405	Gamma-glutamyltransferase
DSM110093_RS19655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS19660	COG0601	transmembrane transport
DSM110093_RS19665	COG0747	negative chemotaxis
DSM110093_RS19670	COG4608	Belongs to the ABC transporter superfamily
DSM110093_RS19685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM110093_RS19690	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DSM110093_RS19710	COG1280	lysine exporter protein (LysE YggA)
DSM110093_RS19735	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DSM110093_RS19740	COG1349	DNA-binding transcription factor activity
DSM110093_RS19750	COG3842	ATPase activity
DSM110093_RS19765	COG0395	ABC-type sugar transport system, permease component
DSM110093_RS19780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DSM110093_RS19785	COG1454	alcohol dehydrogenase
DSM110093_RS19795	COG0405	Gamma-glutamyltransferase
DSM110093_RS19800	COG4608	Belongs to the ABC transporter superfamily
DSM110093_RS19805	COG0444	Belongs to the ABC transporter superfamily
DSM110093_RS19810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS19815	COG0601	transmembrane transport
DSM110093_RS19820	COG0747	negative chemotaxis
DSM110093_RS19825	COG1414	Transcriptional regulator
DSM110093_RS19830	COG0753	catalase activity
DSM110093_RS19855	COG0625	glutathione transferase activity
DSM110093_RS19870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM110093_RS19875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM110093_RS19880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSM110093_RS19890	COG2943	transferase activity, transferring hexosyl groups
DSM110093_RS19900	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DSM110093_RS19905	COG3128	pkhd-type hydroxylase
DSM110093_RS19910	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DSM110093_RS19920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM110093_RS19925	COG0765	amino acid transport
DSM110093_RS19940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM110093_RS19945	COG3938	Belongs to the proline racemase family
DSM110093_RS19955	COG3938	Belongs to the proline racemase family
DSM110093_RS19970	COG4533	DNA binding
DSM110093_RS19980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS19985	COG0444	Belongs to the ABC transporter superfamily
DSM110093_RS20000	COG0601	transmembrane transport
DSM110093_RS20005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS20020	COG1609	Transcriptional regulator
DSM110093_RS20035	COG0673	inositol 2-dehydrogenase activity
DSM110093_RS20040	COG1129	ABC transporter
DSM110093_RS20045	COG1172	Belongs to the binding-protein-dependent transport system permease family
DSM110093_RS20050	COG1879	ABC-type sugar transport system periplasmic component
DSM110093_RS20055	COG1070	Carbohydrate kinase
DSM110093_RS20060	COG0402	S-adenosylhomocysteine deaminase activity
DSM110093_RS20075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DSM110093_RS20080	COG4608	Belongs to the ABC transporter superfamily
DSM110093_RS20085	COG0444	Belongs to the ABC transporter superfamily
DSM110093_RS20090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS20095	COG0601	transmembrane transport
DSM110093_RS20110	COG0402	S-adenosylhomocysteine deaminase activity
DSM110093_RS20115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM110093_RS20120	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DSM110093_RS20125	COG2080	2 iron, 2 sulfur cluster binding
DSM110093_RS20135	COG3547	Transposase (IS116 IS110 IS902 family)
DSM110093_RS20150	COG0583	DNA-binding transcription factor activity
DSM110093_RS20160	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DSM110093_RS20165	COG3485	protocatechuate 3,4-dioxygenase
DSM110093_RS20170	COG3485	protocatechuate 3,4-dioxygenase
DSM110093_RS20215	COG1012	belongs to the aldehyde dehydrogenase family
DSM110093_RS20220	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS20245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM110093_RS20270	COG0405	Gamma-glutamyltransferase
DSM110093_RS20275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM110093_RS20290	COG4172	Belongs to the ABC transporter superfamily
DSM110093_RS20300	COG0601	transmembrane transport
DSM110093_RS20305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM110093_RS20310	COG0668	transmembrane transport
DSM110093_RS20315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DSM110093_RS20325	COG0438	transferase activity, transferring glycosyl groups
DSM110093_RS20330	COG0438	transferase activity, transferring glycosyl groups
DSM110093_RS20350	COG2274	protein secretion by the type I secretion system
DSM110093_RS20355	COG0754	glutathionylspermidine amidase activity
DSM110093_RS20360	COG5463	Belongs to the UPF0441 family
DSM110093_RS20365	COG3781	membrane
DSM110093_RS20375	COG3246	L-lysine catabolic process to acetate
DSM110093_RS20380	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM110093_RS20380	COG1024	Enoyl-CoA hydratase
DSM110093_RS20385	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS20390	COG0583	DNA-binding transcription factor activity
DSM110093_RS20395	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DSM110093_RS20405	COG2721	sulfolactate sulfo-lyase activity
DSM110093_RS20415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DSM110093_RS20420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM110093_RS20440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM110093_RS20455	COG1691	(AIR) carboxylase
DSM110093_RS20460	COG1606	tRNA processing
DSM110093_RS20465	COG2186	Transcriptional regulator
DSM110093_RS20470	COG2358	TRAP transporter, solute receptor (TAXI family
DSM110093_RS20475	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM110093_RS20475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM110093_RS20480	COG0028	Belongs to the TPP enzyme family
DSM110093_RS20485	COG0277	FAD linked oxidase domain protein
DSM110093_RS20490	COG1028	Short-chain dehydrogenase reductase Sdr
DSM110093_RS20495	COG1309	transcriptional regulator
DSM110093_RS20505	COG0829	nickel cation binding
DSM110093_RS20510	COG0831	urea catabolic process
DSM110093_RS20520	COG0832	Belongs to the urease beta subunit family
DSM110093_RS20525	COG0804	urea catabolic process
DSM110093_RS20530	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DSM110093_RS20535	COG0830	nickel cation binding
DSM110093_RS20540	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DSM110093_RS20555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM110093_RS20585	COG1522	sequence-specific DNA binding
DSM110093_RS20595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DSM110093_RS20615	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM110093_RS20635	COG1126	abc transporter atp-binding protein
DSM110093_RS20650	COG2204	response regulator
DSM110093_RS20660	COG0437	4 iron, 4 sulfur cluster binding
DSM110093_RS20665	COG0243	molybdopterin cofactor binding
DSM110093_RS20665	COG3383	formate dehydrogenase (NAD+) activity
DSM110093_RS20700	COG0489	protein tyrosine kinase activity
DSM110093_RS20810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs