locus-tag	class	description
C1J05_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1J05_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1J05_RS00025	COG2271	Major facilitator Superfamily
C1J05_RS00030	COG1054	Belongs to the UPF0176 family
C1J05_RS00035	COG1335	isochorismatase
C1J05_RS00045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C1J05_RS00050	COG0697	spore germination
C1J05_RS00060	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1J05_RS00070	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C1J05_RS00085	COG0514	ATP-dependent DNA helicase (RecQ)
C1J05_RS00090	COG3022	response to hydroperoxide
C1J05_RS00095	COG2205	protein histidine kinase activity
C1J05_RS00095	COG0784	Response regulator, receiver
C1J05_RS00095	COG5002	protein histidine kinase activity
C1J05_RS00115	COG0714	Associated with various cellular activities
C1J05_RS00130	COG3622	Belongs to the hyi family
C1J05_RS00135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1J05_RS00135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1J05_RS00155	COG0791	NLP P60 protein
C1J05_RS00160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1J05_RS00170	COG0288	reversible hydration of carbon dioxide
C1J05_RS00185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1J05_RS00205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1J05_RS00220	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1J05_RS00225	COG3191	aminopeptidase activity
C1J05_RS00230	COG0662	Cupin 2, conserved barrel domain protein
C1J05_RS00240	COG0625	glutathione transferase activity
C1J05_RS00255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J05_RS00260	COG0601	transmembrane transport
C1J05_RS00270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1J05_RS00275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1J05_RS00285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J05_RS00295	COG0473	3-isopropylmalate dehydrogenase activity
C1J05_RS00310	COG0066	3-isopropylmalate dehydratase activity
C1J05_RS00320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1J05_RS00325	COG3264	Mechanosensitive ion channel
C1J05_RS00325	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1J05_RS00335	COG0799	negative regulation of ribosome biogenesis
C1J05_RS00340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1J05_RS00355	COG0277	FAD linked oxidase domain protein
C1J05_RS00360	COG0277	FAD linked oxidase domain protein
C1J05_RS00365	COG0247	lactate metabolic process
C1J05_RS00370	COG3591	Belongs to the peptidase S1B family
C1J05_RS00385	COG2304	oxidoreductase activity
C1J05_RS00395	COG1663	tetraacyldisaccharide 4'-kinase activity
C1J05_RS00415	COG0312	modulator of DNA gyrase
C1J05_RS00435	COG1024	Enoyl-CoA hydratase
C1J05_RS00440	COG1511	domain protein
C1J05_RS00440	COG3264	Mechanosensitive ion channel
C1J05_RS00445	COG2081	HI0933 family
C1J05_RS00450	COG0625	glutathione transferase activity
C1J05_RS00465	COG0495	leucyl-tRNA aminoacylation
C1J05_RS00480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1J05_RS00495	COG0745	RESPONSE REGULATOR receiver
C1J05_RS00500	COG0708	Exodeoxyribonuclease III
C1J05_RS00510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1J05_RS00515	COG2835	tetraacyldisaccharide 4'-kinase activity
C1J05_RS00520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1J05_RS00530	COG0436	Aminotransferase
C1J05_RS00535	COG1674	ftsk spoiiie
C1J05_RS00555	COG0405	Gamma-glutamyltransferase
C1J05_RS00565	COG1366	Belongs to the anti-sigma-factor antagonist family
C1J05_RS00570	COG0183	Belongs to the thiolase family
C1J05_RS00580	COG3046	protein related to deoxyribodipyrimidine photolyase
C1J05_RS00610	COG1280	lysine exporter protein (LysE YggA)
C1J05_RS00625	COG1280	lysine exporter protein (LysE YggA)
C1J05_RS00630	COG2040	homocysteine
C1J05_RS00645	COG0564	pseudouridine synthase activity
C1J05_RS00660	COG0450	alkyl hydroperoxide reductase
C1J05_RS00675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1J05_RS00680	COG1185	polyribonucleotide nucleotidyltransferase activity
C1J05_RS00685	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1J05_RS00715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1J05_RS00725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1J05_RS00730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1J05_RS00745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1J05_RS00745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1J05_RS00755	COG0138	bifunctional purine biosynthesis protein purh
C1J05_RS00760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1J05_RS00770	COG0612	Peptidase, M16
C1J05_RS00775	COG0612	Peptidase, M16
C1J05_RS00780	COG1012	belongs to the aldehyde dehydrogenase family
C1J05_RS00785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1J05_RS00790	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1J05_RS00795	COG1121	(ABC) transporter
C1J05_RS00800	COG1321	iron dependent repressor
C1J05_RS00800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1J05_RS00805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1J05_RS00815	COG3257	ureidoglycine aminohydrolase activity
C1J05_RS00825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1J05_RS00850	COG3806	Anti-sigma factor
C1J05_RS00855	COG1595	DNA-templated transcription, initiation
C1J05_RS00895	COG0625	glutathione transferase activity
C1J05_RS00910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J05_RS00915	COG2755	lipolytic protein G-D-S-L family
C1J05_RS00915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1J05_RS00920	COG1917	Cupin 2, conserved barrel domain protein
C1J05_RS00945	COG0384	phenazine biosynthesis protein PhzF
C1J05_RS00950	COG1960	acyl-CoA dehydrogenase activity
C1J05_RS00985	COG4948	Mandelate Racemase Muconate Lactonizing
C1J05_RS01015	COG0469	pyruvate kinase activity
C1J05_RS01025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1J05_RS01030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1J05_RS01035	COG2070	2-Nitropropane dioxygenase
C1J05_RS01045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1J05_RS01055	COG3039	Transposase
C1J05_RS01065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1J05_RS01065	COG0072	phenylalanine-tRNA ligase activity
C1J05_RS01075	COG0625	glutathione transferase activity
C1J05_RS01080	COG1970	mechanosensitive ion channel activity
C1J05_RS01085	COG0668	transmembrane transport
C1J05_RS01095	COG0596	Alpha beta hydrolase
C1J05_RS01100	COG0686	Belongs to the AlaDH PNT family
C1J05_RS01105	COG1522	sequence-specific DNA binding
C1J05_RS01130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1J05_RS01140	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS01140	COG0604	alcohol dehydrogenase
C1J05_RS01140	COG3321	synthase
C1J05_RS01160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1J05_RS01175	COG2321	neutral zinc metallopeptidase
C1J05_RS01185	COG0737	Belongs to the 5'-nucleotidase family
C1J05_RS01200	COG1605	Chorismate mutase
C1J05_RS01200	COG0077	Prephenate dehydratase
C1J05_RS01215	COG4174	ABC transporter (Permease)
C1J05_RS01220	COG4239	(ABC) transporter, permease
C1J05_RS01225	COG4172	Belongs to the ABC transporter superfamily
C1J05_RS01230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1J05_RS01235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1J05_RS01260	COG2010	Cytochrome c
C1J05_RS01270	COG0583	DNA-binding transcription factor activity
C1J05_RS01275	COG0348	domain, Protein
C1J05_RS01300	COG1686	Belongs to the peptidase S11 family
C1J05_RS01315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1J05_RS01320	COG2813	Specifically methylates the guanine in position
C1J05_RS01330	COG0408	coproporphyrinogen oxidase activity
C1J05_RS01335	COG0181	hydroxymethylbilane synthase activity
C1J05_RS01340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1J05_RS01365	COG0438	transferase activity, transferring glycosyl groups
C1J05_RS01380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C1J05_RS01385	COG0668	transmembrane transport
C1J05_RS01390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1J05_RS01395	COG0284	orotidine-5'-phosphate decarboxylase activity
C1J05_RS01410	COG0542	response to heat
C1J05_RS01415	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C1J05_RS01425	COG0069	glutamate synthase activity
C1J05_RS01430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1J05_RS01435	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C1J05_RS01540	COG0747	negative chemotaxis
C1J05_RS01570	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1J05_RS01575	COG0395	ABC-type sugar transport system, permease component
C1J05_RS01580	COG1175	transmembrane transport
C1J05_RS01595	COG1349	DNA-binding transcription factor activity
C1J05_RS01610	COG2826	transposase and inactivated derivatives, IS30 family
C1J05_RS01625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1J05_RS01660	COG0628	permease
C1J05_RS01710	COG2894	cell division
C1J05_RS01750	COG0235	Class ii aldolase
C1J05_RS01755	COG3395	kinase activity
C1J05_RS01770	COG0473	3-isopropylmalate dehydrogenase activity
C1J05_RS01780	COG1802	Transcriptional regulator
C1J05_RS01785	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1J05_RS01790	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1J05_RS01800	COG2151	metal-sulfur cluster biosynthetic enzyme
C1J05_RS01800	COG0489	protein tyrosine kinase activity
C1J05_RS01805	COG0254	rRNA binding
C1J05_RS01810	COG0335	large ribosomal subunit rRNA binding
C1J05_RS01820	COG0336	Belongs to the RNA methyltransferase TrmD family
C1J05_RS01830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1J05_RS01835	COG0778	Nitroreductase
C1J05_RS01840	COG0228	four-way junction DNA binding
C1J05_RS01860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1J05_RS01870	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1J05_RS01900	COG0356	it plays a direct role in the translocation of protons across the membrane
C1J05_RS01915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1J05_RS01920	COG2186	Transcriptional regulator
C1J05_RS01950	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C1J05_RS01960	COG0435	Glutathione S-transferase
C1J05_RS01970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1J05_RS01975	COG0242	peptide deformylase activity
C1J05_RS01980	COG0242	peptide deformylase activity
C1J05_RS01985	COG0242	peptide deformylase activity
C1J05_RS01990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1J05_RS02005	COG2860	membrane
C1J05_RS02010	COG0328	RNA-DNA hybrid ribonuclease activity
C1J05_RS02025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1J05_RS02035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1J05_RS02040	COG1758	RNA polymerase activity
C1J05_RS02055	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1J05_RS02060	COG0736	holo-[acyl-carrier-protein] synthase activity
C1J05_RS02065	COG0681	Belongs to the peptidase S26 family
C1J05_RS02070	COG0571	ribonuclease III activity
C1J05_RS02075	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1J05_RS02085	COG1381	Involved in DNA repair and RecF pathway recombination
C1J05_RS02105	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1J05_RS02110	COG0745	RESPONSE REGULATOR receiver
C1J05_RS02115	COG2205	protein histidine kinase activity
C1J05_RS02120	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C1J05_RS02125	COG1660	Displays ATPase and GTPase activities
C1J05_RS02135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1J05_RS02145	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J05_RS02165	COG2096	Adenosyltransferase
C1J05_RS02175	COG0300	oxidoreductase activity
C1J05_RS02185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1J05_RS02195	COG0501	Belongs to the peptidase M48B family
C1J05_RS02200	COG2124	cytochrome p450
C1J05_RS02210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1J05_RS02235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1J05_RS02240	COG0250	Participates in transcription elongation, termination and antitermination
C1J05_RS02245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1J05_RS02250	COG0081	regulation of translation
C1J05_RS02255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1J05_RS02260	COG0222	ribosome binding
C1J05_RS02265	COG0085	RNA polymerase activity
C1J05_RS02270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1J05_RS02280	COG0697	spore germination
C1J05_RS02290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1J05_RS02295	COG0049	tRNA binding
C1J05_RS02300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1J05_RS02305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1J05_RS02310	COG0051	transcription antitermination factor activity, RNA binding
C1J05_RS02315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1J05_RS02320	COG0088	Forms part of the polypeptide exit tunnel
C1J05_RS02325	COG0089	rRNA binding
C1J05_RS02330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1J05_RS02335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1J05_RS02340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1J05_RS02345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1J05_RS02350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1J05_RS02365	COG0255	Belongs to the universal ribosomal protein uL29 family
C1J05_RS02370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1J05_RS02375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1J05_RS02380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1J05_RS02385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1J05_RS02390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1J05_RS02395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1J05_RS02400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1J05_RS02405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1J05_RS02410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1J05_RS02415	COG1841	ribosomal large subunit assembly
C1J05_RS02420	COG0200	Binds to the 23S rRNA
C1J05_RS02425	COG0201	protein transport
C1J05_RS02430	COG0563	adenylate kinase activity
C1J05_RS02435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1J05_RS02440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1J05_RS02445	COG0202	RNA polymerase activity
C1J05_RS02450	COG0203	ribosomal protein L17
C1J05_RS02460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1J05_RS02465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1J05_RS02470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1J05_RS02480	COG0546	phosphoglycolate phosphatase activity
C1J05_RS02490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1J05_RS02495	COG4597	amino acid ABC transporter
C1J05_RS02500	COG0765	amino acid transport
C1J05_RS02505	COG1126	abc transporter atp-binding protein
C1J05_RS02510	COG0588	phosphoglycerate mutase activity
C1J05_RS02525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1J05_RS02530	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1J05_RS02540	COG0706	membrane insertase activity
C1J05_RS02570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1J05_RS02575	COG0594	ribonuclease P activity
C1J05_RS02580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1J05_RS02595	COG5000	phosphorelay sensor kinase activity
C1J05_RS02605	COG0582	viral genome integration into host DNA
C1J05_RS02620	COG1162	GTPase activity
C1J05_RS02630	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C1J05_RS02685	COG1115	amino acid carrier protein
C1J05_RS02705	COG0247	lactate metabolic process
C1J05_RS02705	COG0277	FAD linked oxidase domain protein
C1J05_RS02710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1J05_RS02715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J05_RS02725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J05_RS02725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J05_RS02730	COG1024	Enoyl-CoA hydratase
C1J05_RS02735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J05_RS02745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1J05_RS02750	COG0006	proline dipeptidase activity
C1J05_RS02770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1J05_RS02780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1J05_RS02810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1J05_RS02830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1J05_RS02855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1J05_RS02885	COG3039	Transposase
C1J05_RS02890	COG1522	sequence-specific DNA binding
C1J05_RS02895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J05_RS02905	COG3842	ATPase activity
C1J05_RS02920	COG1177	transmembrane transport
C1J05_RS02930	COG1959	2 iron, 2 sulfur cluster binding
C1J05_RS02945	COG2832	Protein of unknown function (DUF454)
C1J05_RS03005	COG5487	UPF0391 membrane protein
C1J05_RS03015	COG0784	Response regulator, receiver
C1J05_RS03035	COG3237	CsbD-like
C1J05_RS03040	COG3871	stress protein (general stress protein 26)
C1J05_RS03065	COG1175	transmembrane transport
C1J05_RS03070	COG0395	ABC-type sugar transport system, permease component
C1J05_RS03080	COG3842	ATPase activity
C1J05_RS03085	COG3842	ATPase activity
C1J05_RS03095	COG1609	Transcriptional regulator
C1J05_RS03105	COG1082	Xylose isomerase domain protein TIM barrel
C1J05_RS03110	COG0673	inositol 2-dehydrogenase activity
C1J05_RS03115	COG1070	Carbohydrate kinase
C1J05_RS03120	COG2115	Belongs to the xylose isomerase family
C1J05_RS03130	COG0837	glucose binding
C1J05_RS03170	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS03175	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS03195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1J05_RS03195	COG0646	methionine synthase
C1J05_RS03200	COG0583	DNA-binding transcription factor activity
C1J05_RS03240	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1J05_RS03240	COG1672	PFAM Archaeal ATPase
C1J05_RS03250	COG2226	methyltransferase
C1J05_RS03290	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C1J05_RS03295	COG0582	viral genome integration into host DNA
C1J05_RS03340	COG0583	DNA-binding transcription factor activity
C1J05_RS03350	COG3383	formate dehydrogenase (NAD+) activity
C1J05_RS03355	COG3327	negative regulation of DNA-templated transcription, initiation
C1J05_RS03360	COG2030	dehydratase
C1J05_RS03360	COG1012	belongs to the aldehyde dehydrogenase family
C1J05_RS03365	COG2050	protein possibly involved in aromatic compounds catabolism
C1J05_RS03380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1J05_RS03385	COG2151	metal-sulfur cluster biosynthetic enzyme
C1J05_RS03390	COG3396	Phenylacetate-CoA oxygenase
C1J05_RS03395	COG3460	Phenylacetate-CoA oxygenase
C1J05_RS03400	COG3396	Phenylacetate-CoA oxygenase
C1J05_RS03405	COG0183	Belongs to the thiolase family
C1J05_RS03440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J05_RS03440	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J05_RS03445	COG4311	Sarcosine oxidase, delta subunit
C1J05_RS03450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J05_RS03455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1J05_RS03470	COG1115	amino acid carrier protein
C1J05_RS03475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1J05_RS03485	COG2027	D-alanyl-D-alanine carboxypeptidase
C1J05_RS03500	COG1132	(ABC) transporter
C1J05_RS03510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1J05_RS03520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1J05_RS03530	COG0525	valine-tRNA ligase activity
C1J05_RS03545	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C1J05_RS03580	COG0556	nucleotide-excision repair
C1J05_RS03645	COG1960	acyl-CoA dehydrogenase activity
C1J05_RS03660	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS03685	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C1J05_RS03695	COG0424	maF-like protein
C1J05_RS03700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1J05_RS03705	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1J05_RS03715	COG4948	Mandelate Racemase Muconate Lactonizing
C1J05_RS03735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1J05_RS03750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1J05_RS03775	COG1047	Peptidyl-prolyl cis-trans
C1J05_RS03795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1J05_RS03800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1J05_RS03805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1J05_RS03810	COG0735	belongs to the Fur family
C1J05_RS03835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1J05_RS03840	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1J05_RS03850	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1J05_RS03855	COG1702	phosphate starvation-inducible protein PhoH
C1J05_RS03870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1J05_RS03885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1J05_RS03890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1J05_RS03895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1J05_RS03900	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1J05_RS03905	COG3119	arylsulfatase activity
C1J05_RS03930	COG0539	negative regulation of cytoplasmic translation
C1J05_RS03935	COG0776	regulation of translation
C1J05_RS03955	COG0133	tryptophan synthase activity
C1J05_RS03985	COG0193	aminoacyl-tRNA hydrolase activity
C1J05_RS03990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1J05_RS04005	COG1304	FMN binding
C1J05_RS04020	COG0159	tryptophan synthase activity
C1J05_RS04025	COG0012	GTP binding
C1J05_RS04105	COG0583	DNA-binding transcription factor activity
C1J05_RS04115	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1J05_RS04120	COG0697	spore germination
C1J05_RS04135	COG0235	Class ii aldolase
C1J05_RS04200	COG0668	transmembrane transport
C1J05_RS04245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1J05_RS04280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1J05_RS04285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1J05_RS04295	COG4221	oxidoreductase activity
C1J05_RS04385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J05_RS04390	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J05_RS04390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J05_RS04410	COG2814	Major facilitator Superfamily
C1J05_RS04415	COG0667	Aldo Keto reductase
C1J05_RS04425	COG3039	Transposase
C1J05_RS04475	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C1J05_RS04475	COG3608	succinylglutamate desuccinylase aspartoacylase
C1J05_RS04480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1J05_RS04490	COG0471	metal ion transport
C1J05_RS04510	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C1J05_RS04515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1J05_RS04540	COG2226	methyltransferase
C1J05_RS04585	COG2010	Cytochrome c
C1J05_RS04625	COG1902	pentaerythritol trinitrate reductase activity
C1J05_RS04640	COG3228	Belongs to the MtfA family
C1J05_RS04655	COG1132	(ABC) transporter
C1J05_RS04665	COG1234	tRNA 3'-trailer cleavage
C1J05_RS04675	COG0318	PFAM AMP-dependent synthetase and ligase
C1J05_RS04685	COG4172	Belongs to the ABC transporter superfamily
C1J05_RS04690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J05_RS04700	COG4166	transmembrane transport
C1J05_RS04710	COG2379	hydroxypyruvate reductase
C1J05_RS04760	COG0590	tRNA wobble adenosine to inosine editing
C1J05_RS04765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1J05_RS04770	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1J05_RS04775	COG0154	amidase activity
C1J05_RS04785	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1J05_RS04800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1J05_RS04830	COG0670	Belongs to the BI1 family
C1J05_RS04840	COG0583	DNA-binding transcription factor activity
C1J05_RS04850	COG1396	sequence-specific DNA binding
C1J05_RS04855	COG0483	inositol monophosphate 1-phosphatase activity
C1J05_RS04870	COG0402	S-adenosylhomocysteine deaminase activity
C1J05_RS04875	COG2239	Acts as a magnesium transporter
C1J05_RS04880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1J05_RS04885	COG1692	metallophosphoesterase
C1J05_RS04895	COG3273	potassium ion transport
C1J05_RS04895	COG0471	metal ion transport
C1J05_RS04905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1J05_RS04910	COG1741	Belongs to the pirin family
C1J05_RS04915	COG0471	metal ion transport
C1J05_RS04915	COG0490	domain, Protein
C1J05_RS04920	COG0217	transcriptional regulatory protein
C1J05_RS04925	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C1J05_RS04925	COG0778	Nitroreductase
C1J05_RS04945	COG4175	Glycine betaine
C1J05_RS04960	COG1309	transcriptional regulator
C1J05_RS04965	COG3119	arylsulfatase activity
C1J05_RS04970	COG0625	glutathione transferase activity
C1J05_RS04995	COG3800	Transcriptional regulator
C1J05_RS04995	COG1396	sequence-specific DNA binding
C1J05_RS05000	COG2814	Major facilitator Superfamily
C1J05_RS05005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1J05_RS05030	COG4770	biotin carboxylase activity
C1J05_RS05050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J05_RS05050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J05_RS05070	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1J05_RS05085	COG0248	Ppx GppA phosphatase
C1J05_RS05090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1J05_RS05100	COG0628	permease
C1J05_RS05105	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C1J05_RS05110	COG0442	prolyl-tRNA aminoacylation
C1J05_RS05125	COG1136	(ABC) transporter
C1J05_RS05130	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C1J05_RS05160	COG0187	DNA topoisomerase II activity
C1J05_RS05175	COG2207	Transcriptional regulator
C1J05_RS05175	COG3708	Transcriptional regulator
C1J05_RS05190	COG2326	polyphosphate kinase activity
C1J05_RS05205	COG0534	Mate efflux family protein
C1J05_RS05250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1J05_RS05290	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C1J05_RS05295	COG3039	Transposase
C1J05_RS05300	COG1278	Cold shock
C1J05_RS05305	COG1393	Belongs to the ArsC family
C1J05_RS05325	COG3220	belongs to the UPF0276 family
C1J05_RS05335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1J05_RS05370	COG3243	poly(R)-hydroxyalkanoic acid synthase
C1J05_RS05385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1J05_RS05390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J05_RS05395	COG0174	glutamine synthetase
C1J05_RS05400	COG0519	Catalyzes the synthesis of GMP from XMP
C1J05_RS05405	COG0174	glutamine synthetase
C1J05_RS05415	COG4215	(ABC) transporter
C1J05_RS05455	COG0504	CTP synthase activity
C1J05_RS05490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1J05_RS05515	COG1760	l-serine dehydratase
C1J05_RS05520	COG0625	glutathione transferase activity
C1J05_RS05525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C1J05_RS05540	COG0330	HflC and HflK could
C1J05_RS05550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1J05_RS05560	COG0587	DNA-directed DNA polymerase activity
C1J05_RS05580	COG1570	exodeoxyribonuclease VII activity
C1J05_RS05595	COG0552	protein localization to endoplasmic reticulum
C1J05_RS05605	COG2917	probably involved in intracellular septation
C1J05_RS05610	COG0625	glutathione transferase activity
C1J05_RS05620	COG0006	proline dipeptidase activity
C1J05_RS05630	COG0583	DNA-binding transcription factor activity
C1J05_RS05635	COG1469	GTP cyclohydrolase I activity
C1J05_RS05650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1J05_RS05665	COG0752	glycyl-tRNA synthetase alpha subunit
C1J05_RS05680	COG0751	glycine-tRNA ligase activity
C1J05_RS05685	COG0574	Belongs to the PEP-utilizing enzyme family
C1J05_RS05685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1J05_RS05695	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1J05_RS05700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1J05_RS05705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1J05_RS05720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1J05_RS05725	COG1522	sequence-specific DNA binding
C1J05_RS05730	COG1522	sequence-specific DNA binding
C1J05_RS05755	COG1802	Transcriptional regulator
C1J05_RS05765	COG0505	Belongs to the CarA family
C1J05_RS05795	COG3039	Transposase
C1J05_RS05805	COG0321	lipoyl(octanoyl) transferase activity
C1J05_RS05870	COG1672	PFAM Archaeal ATPase
C1J05_RS05870	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1J05_RS05890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1J05_RS05895	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J05_RS05900	COG0022	dehydrogenase e1 component
C1J05_RS05900	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J05_RS05905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1J05_RS05925	COG0745	RESPONSE REGULATOR receiver
C1J05_RS05935	COG3609	addiction module antidote protein, CC2985 family
C1J05_RS05965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1J05_RS05970	COG0110	maltose O-acetyltransferase activity
C1J05_RS05975	COG0438	transferase activity, transferring glycosyl groups
C1J05_RS05980	COG0438	transferase activity, transferring glycosyl groups
C1J05_RS05990	COG0438	transferase activity, transferring glycosyl groups
C1J05_RS06030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1J05_RS06035	COG0673	inositol 2-dehydrogenase activity
C1J05_RS06055	COG0438	transferase activity, transferring glycosyl groups
C1J05_RS06065	COG0463	Glycosyl transferase, family 2
C1J05_RS06080	COG1215	transferase activity, transferring glycosyl groups
C1J05_RS06085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1J05_RS06085	COG0519	Catalyzes the synthesis of GMP from XMP
C1J05_RS06185	COG0745	RESPONSE REGULATOR receiver
C1J05_RS06205	COG0076	glutamate decarboxylase activity
C1J05_RS06260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1J05_RS06270	COG0747	negative chemotaxis
C1J05_RS06275	COG0601	transmembrane transport
C1J05_RS06280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J05_RS06285	COG4172	Belongs to the ABC transporter superfamily
C1J05_RS06305	COG1363	Peptidase, m42
C1J05_RS06320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J05_RS06325	COG0583	DNA-binding transcription factor activity
C1J05_RS06330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1J05_RS06335	COG3842	ATPase activity
C1J05_RS06340	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J05_RS06345	COG1177	transmembrane transport
C1J05_RS06350	COG1012	belongs to the aldehyde dehydrogenase family
C1J05_RS06355	COG0583	DNA-binding transcription factor activity
C1J05_RS06370	COG4176	ABC-type proline glycine betaine transport system permease component
C1J05_RS06375	COG2267	carboxylic ester hydrolase activity
C1J05_RS06380	COG0306	phosphate transporter
C1J05_RS06395	COG1067	ATP-dependent peptidase activity
C1J05_RS06405	COG0484	heat shock protein binding
C1J05_RS06465	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C1J05_RS06480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1J05_RS06485	COG3002	Belongs to the UPF0753 family
C1J05_RS06490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1J05_RS06535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1J05_RS06555	COG3639	organic phosphonate transmembrane transporter activity
C1J05_RS06560	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C1J05_RS06575	COG1228	amidohydrolase
C1J05_RS06580	COG2986	histidine ammonia-lyase
C1J05_RS06590	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1J05_RS06615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1J05_RS06620	COG3039	Transposase
C1J05_RS06650	COG0069	glutamate synthase activity
C1J05_RS06655	COG2218	PFAM glutamate synthase alpha subunit domain protein
C1J05_RS06660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1J05_RS06670	COG2132	Multicopper oxidase
C1J05_RS06680	COG0436	Aminotransferase
C1J05_RS06685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1J05_RS06735	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J05_RS06740	COG1177	transmembrane transport
C1J05_RS06745	COG3842	ATPase activity
C1J05_RS06805	COG0004	ammonium transporteR
C1J05_RS06810	COG0004	ammonium transporteR
C1J05_RS06830	COG0668	transmembrane transport
C1J05_RS06840	COG0174	glutamine synthetase
C1J05_RS06860	COG4638	Rieske (2fe-2S)
C1J05_RS06885	COG3246	L-lysine catabolic process to acetate
C1J05_RS06895	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C1J05_RS06900	COG1609	Transcriptional regulator
C1J05_RS06915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J05_RS06920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J05_RS06920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J05_RS06925	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1J05_RS06930	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS06935	COG1063	alcohol dehydrogenase
C1J05_RS06955	COG1304	FMN binding
C1J05_RS06975	COG1012	belongs to the aldehyde dehydrogenase family
C1J05_RS06980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1J05_RS06990	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J05_RS07000	COG3246	L-lysine catabolic process to acetate
C1J05_RS07020	COG1177	transmembrane transport
C1J05_RS07025	COG1960	acyl-CoA dehydrogenase activity
C1J05_RS07060	COG0747	negative chemotaxis
C1J05_RS07065	COG0601	transmembrane transport
C1J05_RS07070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J05_RS07075	COG0444	Belongs to the ABC transporter superfamily
C1J05_RS07130	COG2826	transposase and inactivated derivatives, IS30 family
C1J05_RS07135	COG0251	oxidation-reduction process
C1J05_RS07155	COG3246	L-lysine catabolic process to acetate
C1J05_RS07160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J05_RS07175	COG1177	transmembrane transport
C1J05_RS07180	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J05_RS07185	COG0583	DNA-binding transcription factor activity
C1J05_RS07190	COG2362	D-Aminopeptidase
C1J05_RS07200	COG1177	transmembrane transport
C1J05_RS07215	COG3842	ATPase activity
C1J05_RS07225	COG0006	proline dipeptidase activity
C1J05_RS07235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J05_RS07240	COG2423	ornithine cyclodeaminase activity
C1J05_RS07245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1J05_RS07250	COG0006	proline dipeptidase activity
C1J05_RS07270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J05_RS07285	COG3039	Transposase
C1J05_RS07305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J05_RS07325	COG0318	PFAM AMP-dependent synthetase and ligase
C1J05_RS07335	COG3842	ATPase activity
C1J05_RS07340	COG3842	ATPase activity
C1J05_RS07345	COG1175	transmembrane transport
C1J05_RS07350	COG0395	ABC-type sugar transport system, permease component
C1J05_RS07375	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1J05_RS07380	COG1091	dTDP-4-dehydrorhamnose reductase activity
C1J05_RS07385	COG1088	dTDP-glucose 4,6-dehydratase activity
C1J05_RS07455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1J05_RS07460	COG0563	adenylate kinase activity
C1J05_RS07470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1J05_RS07475	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C1J05_RS07485	COG2176	DNA-directed DNA polymerase activity
C1J05_RS07485	COG5002	protein histidine kinase activity
C1J05_RS07495	COG0517	IMP dehydrogenase activity
C1J05_RS07495	COG4175	Glycine betaine
C1J05_RS07500	COG4176	ABC-type proline glycine betaine transport system permease component
C1J05_RS07545	COG1414	Transcriptional regulator
C1J05_RS07570	COG3842	ATPase activity
C1J05_RS07575	COG1177	transmembrane transport
C1J05_RS07615	COG0601	transmembrane transport
C1J05_RS07620	COG0747	negative chemotaxis
C1J05_RS07635	COG2351	hydroxyisourate hydrolase activity
C1J05_RS07640	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C1J05_RS07650	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1J05_RS07655	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J05_RS07655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J05_RS07660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J05_RS07665	COG1349	DNA-binding transcription factor activity
C1J05_RS07685	COG0174	glutamine synthetase
C1J05_RS07690	COG1012	belongs to the aldehyde dehydrogenase family
C1J05_RS07700	COG1840	ABC-type Fe3 transport system, periplasmic component
C1J05_RS07705	COG3842	ATPase activity
C1J05_RS07720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1J05_RS07730	COG1012	belongs to the aldehyde dehydrogenase family
C1J05_RS07735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J05_RS07745	COG1349	DNA-binding transcription factor activity
C1J05_RS07775	COG2995	paraquat-inducible protein a
C1J05_RS07780	COG3008	intermembrane lipid transfer
C1J05_RS07780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1J05_RS07805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J05_RS07815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J05_RS07815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J05_RS07830	COG1984	allophanate hydrolase subunit 2
C1J05_RS07835	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1J05_RS07840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J05_RS07850	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J05_RS07860	COG2391	methyltransferase activity
C1J05_RS07880	COG0785	Cytochrome C biogenesis protein
C1J05_RS07905	COG3258	Cytochrome c
C1J05_RS07910	COG0737	Belongs to the 5'-nucleotidase family
C1J05_RS07925	COG3474	cytochrome
C1J05_RS07930	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J05_RS07940	COG0740	serine-type endopeptidase activity
C1J05_RS07945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1J05_RS07950	COG0251	oxidation-reduction process
C1J05_RS07970	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1J05_RS07975	COG0439	Biotin carboxylase
C1J05_RS07980	COG0511	ligase activity, forming carbon-carbon bonds
C1J05_RS07990	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS08000	COG0410	ABC transporter
C1J05_RS08025	COG3800	Transcriptional regulator
C1J05_RS08025	COG1396	sequence-specific DNA binding
C1J05_RS08030	COG0745	RESPONSE REGULATOR receiver
C1J05_RS08060	COG2391	methyltransferase activity
C1J05_RS08090	COG0848	biopolymer transport protein
C1J05_RS08095	COG0811	peptide transport
C1J05_RS08110	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1J05_RS08125	COG4206	TonB-dependent receptor
C1J05_RS08130	COG3750	Belongs to the UPF0335 family
C1J05_RS08135	COG0457	Tetratricopeptide repeat
C1J05_RS08145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1J05_RS08180	COG0563	adenylate kinase activity
C1J05_RS08185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1J05_RS08195	COG0604	alcohol dehydrogenase
C1J05_RS08200	COG1917	Cupin 2, conserved barrel domain protein
C1J05_RS08225	COG1063	alcohol dehydrogenase
C1J05_RS08250	COG0523	cobalamin synthesis protein
C1J05_RS08265	COG1121	(ABC) transporter
C1J05_RS08270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1J05_RS08280	COG1136	(ABC) transporter
C1J05_RS08300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1J05_RS08305	COG0730	response to heat
C1J05_RS08325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1J05_RS08330	COG4235	cytochrome complex assembly
C1J05_RS08335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J05_RS08350	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J05_RS08350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J05_RS08360	COG0010	Belongs to the arginase family
C1J05_RS08400	COG5265	(ABC) transporter
C1J05_RS08430	COG1160	GTP binding
C1J05_RS08435	COG0006	proline dipeptidase activity
C1J05_RS08450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1J05_RS08460	COG1862	Preprotein translocase
C1J05_RS08465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1J05_RS08470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1J05_RS08480	COG3737	Protein of unknown function (DUF498/DUF598)
C1J05_RS08485	COG4133	protoheme IX ABC transporter activity
C1J05_RS08490	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1J05_RS08495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1J05_RS08505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1J05_RS08535	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1J05_RS08555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1J05_RS08620	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1J05_RS08640	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1J05_RS08685	COG3039	Transposase
C1J05_RS08690	COG3039	Transposase
C1J05_RS08695	COG0582	viral genome integration into host DNA
C1J05_RS08705	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1J05_RS08720	COG0359	binds to the 23S rRNA
C1J05_RS08725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1J05_RS08730	COG0360	Binds together with S18 to 16S ribosomal RNA
C1J05_RS08750	COG3038	cytochrome b561
C1J05_RS08755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1J05_RS08765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1J05_RS08775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1J05_RS08780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1J05_RS08785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1J05_RS08795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1J05_RS08805	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J05_RS08810	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J05_RS08810	COG0022	dehydrogenase e1 component
C1J05_RS08815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1J05_RS08820	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C1J05_RS08825	COG3588	fructose-bisphosphate aldolase
C1J05_RS08830	COG0126	phosphoglycerate kinase activity
C1J05_RS08850	COG0739	heme binding
C1J05_RS08855	COG2833	Protein of unknown function (DUF455)
C1J05_RS08860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1J05_RS08870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1J05_RS08875	COG2814	Major facilitator Superfamily
C1J05_RS08885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1J05_RS08890	COG2226	methyltransferase
C1J05_RS08920	COG1960	acyl-CoA dehydrogenase activity
C1J05_RS08930	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1J05_RS08965	COG3547	Transposase (IS116 IS110 IS902 family)
C1J05_RS08980	COG0517	IMP dehydrogenase activity
C1J05_RS08980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1J05_RS08985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1J05_RS08995	COG2354	Protein conserved in bacteria
C1J05_RS09000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1J05_RS09025	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1J05_RS09040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1J05_RS09045	COG0668	transmembrane transport
C1J05_RS09050	COG0583	DNA-binding transcription factor activity
C1J05_RS09065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1J05_RS09070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1J05_RS09075	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C1J05_RS09090	COG1138	Cytochrome C-type biogenesis protein
C1J05_RS09095	COG3088	subunit of a heme lyase
C1J05_RS09100	COG1024	Enoyl-CoA hydratase
C1J05_RS09110	COG0372	Belongs to the citrate synthase family
C1J05_RS09115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1J05_RS09125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1J05_RS09130	COG0303	'Molybdopterin
C1J05_RS09140	COG0134	indole-3-glycerol-phosphate synthase activity
C1J05_RS09145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1J05_RS09175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1J05_RS09210	COG0215	cysteine-tRNA ligase activity
C1J05_RS09215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1J05_RS09225	COG2814	Major facilitator Superfamily
C1J05_RS09245	COG3064	Membrane
C1J05_RS09270	COG0010	Belongs to the arginase family
C1J05_RS09285	COG1238	metal cluster binding
C1J05_RS09380	COG4536	flavin adenine dinucleotide binding
C1J05_RS09385	COG4974	Belongs to the 'phage' integrase family
C1J05_RS09395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1J05_RS09400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1J05_RS09405	COG0629	single-stranded DNA binding
C1J05_RS09410	COG0739	heme binding
C1J05_RS09410	COG1196	nuclear chromosome segregation
C1J05_RS09410	COG0741	lytic transglycosylase activity
C1J05_RS09425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J05_RS09430	COG0601	transmembrane transport
C1J05_RS09440	COG0747	negative chemotaxis
C1J05_RS09450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1J05_RS09455	COG0528	UMP kinase activity
C1J05_RS09460	COG0233	cytoplasmic translational termination
C1J05_RS09465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1J05_RS09475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1J05_RS09480	COG0750	zinc metalloprotease
C1J05_RS09485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1J05_RS09495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1J05_RS09500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1J05_RS09505	COG3494	Protein of unknown function (DUF1009)
C1J05_RS09510	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1J05_RS09515	COG0482	sulfurtransferase activity
C1J05_RS09525	COG0745	RESPONSE REGULATOR receiver
C1J05_RS09530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1J05_RS09545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1J05_RS09550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1J05_RS09555	COG2264	protein methyltransferase activity
C1J05_RS09560	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C1J05_RS09565	COG1024	Enoyl-CoA hydratase
C1J05_RS09575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1J05_RS09580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1J05_RS09585	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1J05_RS09585	COG2755	lipolytic protein G-D-S-L family
C1J05_RS09595	COG1309	transcriptional regulator
C1J05_RS09600	COG2326	polyphosphate kinase activity
C1J05_RS09610	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C1J05_RS09630	COG0697	spore germination
C1J05_RS09640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1J05_RS09640	COG0519	Catalyzes the synthesis of GMP from XMP
C1J05_RS09665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1J05_RS09670	COG2010	Cytochrome c
C1J05_RS09685	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C1J05_RS09690	COG2867	negative regulation of translational initiation
C1J05_RS09700	COG1058	Belongs to the CinA family
C1J05_RS09700	COG1546	Belongs to the CinA family
C1J05_RS09705	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1J05_RS09710	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1J05_RS09710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1J05_RS09715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1J05_RS09720	COG3852	Histidine kinase
C1J05_RS09725	COG2204	response regulator
C1J05_RS09730	COG5000	phosphorelay sensor kinase activity
C1J05_RS09735	COG2204	response regulator
C1J05_RS09745	COG0569	domain protein
C1J05_RS09750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1J05_RS09755	COG1923	regulation of RNA biosynthetic process
C1J05_RS09760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1J05_RS09770	COG2366	antibiotic biosynthetic process
C1J05_RS09775	COG2084	Dehydrogenase
C1J05_RS09800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1J05_RS09805	COG2814	Major facilitator Superfamily
C1J05_RS09810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1J05_RS09830	COG4166	transmembrane transport
C1J05_RS09835	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS09845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1J05_RS09855	COG2313	pseudouridylate synthase activity
C1J05_RS09885	COG1612	heme a metabolic process
C1J05_RS09890	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C1J05_RS09895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1J05_RS09900	COG5425	PFAM Usg family protein
C1J05_RS09905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1J05_RS09910	COG0535	radical SAM domain protein
C1J05_RS09915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1J05_RS09925	COG0166	Belongs to the GPI family
C1J05_RS09955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1J05_RS09965	COG0248	Ppx GppA phosphatase
C1J05_RS09970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1J05_RS10010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1J05_RS10105	COG3743	rRNA binding
C1J05_RS10105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1J05_RS10110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1J05_RS10125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1J05_RS10130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1J05_RS10135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1J05_RS10160	COG0052	Belongs to the universal ribosomal protein uS2 family
C1J05_RS10165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1J05_RS10170	COG2771	luxR family
C1J05_RS10175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1J05_RS10185	COG3485	protocatechuate 3,4-dioxygenase
C1J05_RS10190	COG3485	protocatechuate 3,4-dioxygenase
C1J05_RS10195	COG0022	dehydrogenase e1 component
C1J05_RS10200	COG1960	acyl-CoA dehydrogenase activity
C1J05_RS10205	COG0583	DNA-binding transcription factor activity
C1J05_RS10210	COG0745	RESPONSE REGULATOR receiver
C1J05_RS10215	COG0704	Plays a role in the regulation of phosphate uptake
C1J05_RS10220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1J05_RS10230	COG0573	inorganic phosphate transmembrane transporter activity
C1J05_RS10240	COG5002	protein histidine kinase activity
C1J05_RS10255	COG0194	GDP metabolic process
C1J05_RS10260	COG1561	YicC-like family, N-terminal region
C1J05_RS10270	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C1J05_RS10280	COG2133	pyrroloquinoline quinone binding
C1J05_RS10310	COG0433	COG0433 Predicted ATPase
C1J05_RS10315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1J05_RS10335	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1J05_RS10340	COG2989	Protein conserved in bacteria
C1J05_RS10345	COG3108	Peptidase M15
C1J05_RS10360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1J05_RS10365	COG0582	viral genome integration into host DNA
C1J05_RS10400	COG0625	glutathione transferase activity
C1J05_RS10440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1J05_RS10455	COG0719	Fe-S assembly protein
C1J05_RS10460	COG0396	ATPase activity
C1J05_RS10465	COG0393	Putative heavy-metal-binding
C1J05_RS10475	COG0719	Fe-S assembly protein
C1J05_RS10480	COG1104	cysteine desulfurase activity
C1J05_RS10485	COG1959	2 iron, 2 sulfur cluster binding
C1J05_RS10490	COG2945	thiolester hydrolase activity
C1J05_RS10505	COG0538	isocitrate dehydrogenase activity
C1J05_RS10515	COG1522	sequence-specific DNA binding
C1J05_RS10520	COG2076	Multidrug Resistance protein
C1J05_RS10525	COG1217	gtp-binding protein TYPA
C1J05_RS10535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1J05_RS10540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1J05_RS10555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1J05_RS10570	COG0583	DNA-binding transcription factor activity
C1J05_RS10575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J05_RS10590	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J05_RS10630	COG0668	transmembrane transport
C1J05_RS10650	COG3474	cytochrome
C1J05_RS10660	COG1595	DNA-templated transcription, initiation
C1J05_RS10670	COG0318	PFAM AMP-dependent synthetase and ligase
C1J05_RS10675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1J05_RS10685	COG0668	transmembrane transport
C1J05_RS10690	COG0668	transmembrane transport
C1J05_RS10700	COG3039	Transposase
C1J05_RS10745	COG0402	S-adenosylhomocysteine deaminase activity
C1J05_RS10755	COG5410	chromosome segregation
C1J05_RS10790	COG0406	alpha-ribazole phosphatase activity
C1J05_RS10795	COG2226	methyltransferase
C1J05_RS10805	COG0583	DNA-binding transcription factor activity
C1J05_RS10815	COG1733	regulation of RNA biosynthetic process
C1J05_RS10820	COG2030	dehydratase
C1J05_RS10860	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1J05_RS10860	COG3264	Mechanosensitive ion channel
C1J05_RS10870	COG0494	nUDIX hydrolase
C1J05_RS10880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1J05_RS10885	COG0415	Belongs to the DNA photolyase family
C1J05_RS10890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1J05_RS10895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1J05_RS10900	COG0604	alcohol dehydrogenase
C1J05_RS10905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J05_RS10925	COG2186	Transcriptional regulator
C1J05_RS10960	COG2059	Chromate
C1J05_RS10975	COG0114	fumarate hydratase activity
C1J05_RS11000	COG0785	Cytochrome C biogenesis protein
C1J05_RS11005	COG0425	Belongs to the sulfur carrier protein TusA family
C1J05_RS11010	COG1530	ribonuclease E activity
C1J05_RS11015	COG2204	response regulator
C1J05_RS11025	COG0047	phosphoribosylformylglycinamidine synthase activity
C1J05_RS11030	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1J05_RS11035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1J05_RS11045	COG0646	methionine synthase
C1J05_RS11045	COG1410	methionine synthase
C1J05_RS11055	COG5012	cobalamin binding
C1J05_RS11065	COG2166	iron-sulfur cluster assembly
C1J05_RS11075	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1J05_RS11080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1J05_RS11085	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1J05_RS11130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1J05_RS11240	COG1525	nuclease
C1J05_RS11285	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J05_RS11315	COG0010	Belongs to the arginase family
C1J05_RS11325	COG1012	belongs to the aldehyde dehydrogenase family
C1J05_RS11335	COG0372	Belongs to the citrate synthase family
C1J05_RS11390	COG3119	arylsulfatase activity
C1J05_RS11395	COG0668	transmembrane transport
C1J05_RS11400	COG2207	Transcriptional regulator
C1J05_RS11505	COG1216	Glycosyl transferase, family 2
C1J05_RS11530	COG0250	Participates in transcription elongation, termination and antitermination
C1J05_RS11535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1J05_RS11585	COG1380	Effector of murein hydrolase LrgA
C1J05_RS11590	COG1346	cytolysis
C1J05_RS11595	COG1376	ErfK ybiS ycfS ynhG family protein
C1J05_RS11625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1J05_RS11670	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C1J05_RS11715	COG1126	abc transporter atp-binding protein
C1J05_RS11735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1J05_RS11745	COG2095	MarC family integral membrane protein
C1J05_RS11755	COG0583	DNA-binding transcription factor activity
C1J05_RS11760	COG0583	DNA-binding transcription factor activity
C1J05_RS11770	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J05_RS11780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J05_RS11810	COG0668	transmembrane transport
C1J05_RS11835	COG0514	ATP-dependent DNA helicase (RecQ)
C1J05_RS11845	COG1525	nuclease
C1J05_RS11870	COG1733	regulation of RNA biosynthetic process
C1J05_RS11885	COG0277	FAD linked oxidase domain protein
C1J05_RS11890	COG3547	Transposase (IS116 IS110 IS902 family)
C1J05_RS11950	COG2826	transposase and inactivated derivatives, IS30 family
C1J05_RS11980	COG0765	amino acid transport
C1J05_RS11985	COG0765	amino acid transport
C1J05_RS11990	COG1126	abc transporter atp-binding protein
C1J05_RS12030	COG0402	S-adenosylhomocysteine deaminase activity
C1J05_RS12035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1J05_RS12050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1J05_RS12065	COG1686	Belongs to the peptidase S11 family
C1J05_RS12070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1J05_RS12080	COG0084	hydrolase, TatD family'
C1J05_RS12085	COG0321	lipoyl(octanoyl) transferase activity
C1J05_RS12085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1J05_RS12105	COG0582	viral genome integration into host DNA
C1J05_RS12115	COG0667	Aldo Keto reductase
C1J05_RS12125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1J05_RS12130	COG1127	ABC transporter
C1J05_RS12140	COG3218	ABC-type transport auxiliary lipoprotein component
C1J05_RS12140	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1J05_RS12155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1J05_RS12185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J05_RS12195	COG0588	phosphoglycerate mutase activity
C1J05_RS12240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1J05_RS12250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1J05_RS12250	COG0189	ligase activity
C1J05_RS12255	COG0189	ligase activity
C1J05_RS12255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1J05_RS12265	COG0028	Belongs to the TPP enzyme family
C1J05_RS12275	COG1132	(ABC) transporter
C1J05_RS12290	COG0105	UTP biosynthetic process
C1J05_RS12295	COG0488	(ABC) transporter
C1J05_RS12300	COG2095	MarC family integral membrane protein
C1J05_RS12315	COG3119	arylsulfatase activity
C1J05_RS12325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1J05_RS12340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1J05_RS12350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1J05_RS12355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1J05_RS12365	COG2890	protein-(glutamine-N5) methyltransferase activity
C1J05_RS12370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1J05_RS12385	COG0010	Belongs to the arginase family
C1J05_RS12390	COG1473	amidohydrolase
C1J05_RS12395	COG3956	TIGRFAM MazG family protein
C1J05_RS12410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C1J05_RS12425	COG0513	Belongs to the DEAD box helicase family
C1J05_RS12440	COG0697	spore germination
C1J05_RS12445	COG0148	phosphopyruvate hydratase activity
C1J05_RS12455	COG3239	Fatty acid desaturase
C1J05_RS12460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1J05_RS12465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1J05_RS12495	COG0488	(ABC) transporter
C1J05_RS12515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1J05_RS12520	COG0416	fatty acid biosynthetic process
C1J05_RS12525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1J05_RS12530	COG0776	regulation of translation
C1J05_RS12545	COG0717	Belongs to the dCTP deaminase family
C1J05_RS12555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1J05_RS12560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C1J05_RS12565	COG1472	Belongs to the glycosyl hydrolase 3 family
C1J05_RS12575	COG0018	arginyl-trna synthetase
C1J05_RS12580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1J05_RS12585	COG0316	Belongs to the HesB IscA family
C1J05_RS12615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1J05_RS12625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1J05_RS12700	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C1J05_RS12720	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J05_RS12745	COG0028	Belongs to the TPP enzyme family
C1J05_RS12765	COG4638	Rieske (2fe-2S)
C1J05_RS12780	COG0154	amidase activity
C1J05_RS12785	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1J05_RS12790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1J05_RS12795	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1J05_RS12800	COG0436	Aminotransferase
C1J05_RS12805	COG0501	Belongs to the peptidase M48B family
C1J05_RS12815	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1J05_RS12825	COG0156	8-amino-7-oxononanoate synthase activity
C1J05_RS12830	COG3039	Transposase
C1J05_RS12850	COG3039	Transposase
C1J05_RS12865	COG1741	Belongs to the pirin family
C1J05_RS12890	COG0776	regulation of translation
C1J05_RS12895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1J05_RS12910	COG0343	queuine tRNA-ribosyltransferase activity
C1J05_RS12935	COG2151	metal-sulfur cluster biosynthetic enzyme
C1J05_RS12940	COG0316	Belongs to the HesB IscA family
C1J05_RS12945	COG0149	triose-phosphate isomerase activity
C1J05_RS12950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J05_RS12955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J05_RS12960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J05_RS12975	COG2124	cytochrome p450
C1J05_RS12980	COG1522	sequence-specific DNA binding
C1J05_RS12985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1J05_RS12985	COG1648	precorrin-2 dehydrogenase activity
C1J05_RS13000	COG0175	sulfate reduction
C1J05_RS13020	COG2175	clavaminate synthase activity
C1J05_RS13030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1J05_RS13055	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C1J05_RS13090	COG0418	dihydroorotase activity
C1J05_RS13095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1J05_RS13100	COG0305	Participates in initiation and elongation during chromosome replication
C1J05_RS13110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1J05_RS13115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1J05_RS13120	COG1127	ABC transporter
C1J05_RS13150	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1J05_RS13155	COG3239	Fatty acid desaturase
C1J05_RS13160	COG4221	oxidoreductase activity
C1J05_RS13165	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C1J05_RS13170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1J05_RS13175	COG1388	LysM domain
C1J05_RS13175	COG4942	peptidase
C1J05_RS13185	COG0805	protein transport
C1J05_RS13190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1J05_RS13195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1J05_RS13205	COG3842	ATPase activity
C1J05_RS13210	COG4335	DNA alkylation repair
C1J05_RS13215	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS13235	COG0513	Belongs to the DEAD box helicase family
C1J05_RS13245	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C1J05_RS13255	COG1007	ATP synthesis coupled electron transport
C1J05_RS13270	COG0713	ATP synthesis coupled electron transport
C1J05_RS13285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1J05_RS13295	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1J05_RS13345	COG3743	rRNA binding
C1J05_RS13345	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1J05_RS13355	COG0649	NAD binding
C1J05_RS13360	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1J05_RS13365	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1J05_RS13375	COG1454	alcohol dehydrogenase
C1J05_RS13385	COG1024	Enoyl-CoA hydratase
C1J05_RS13410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1J05_RS13420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1J05_RS13425	COG3047	cAMP biosynthetic process
C1J05_RS13430	COG1960	acyl-CoA dehydrogenase activity
C1J05_RS13435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1J05_RS13440	COG0546	phosphoglycolate phosphatase activity
C1J05_RS13445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1J05_RS13465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1J05_RS13470	COG1519	Transferase
C1J05_RS13480	COG1473	amidohydrolase
C1J05_RS13485	COG1473	amidohydrolase
C1J05_RS13490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J05_RS13495	COG4172	Belongs to the ABC transporter superfamily
C1J05_RS13505	COG0601	transmembrane transport
C1J05_RS13510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J05_RS13520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1J05_RS13540	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS13550	COG0454	-acetyltransferase
C1J05_RS13555	COG3483	tryptophan 2,3-dioxygenase activity
C1J05_RS13565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1J05_RS13570	COG0308	aminopeptidase N
C1J05_RS13590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1J05_RS13605	COG0484	heat shock protein binding
C1J05_RS13620	COG0006	proline dipeptidase activity
C1J05_RS13645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1J05_RS13655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1J05_RS13660	COG0849	cell division
C1J05_RS13665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1J05_RS13670	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1J05_RS13675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1J05_RS13700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1J05_RS13705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1J05_RS13715	COG2081	HI0933 family
C1J05_RS13720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1J05_RS13725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1J05_RS13730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1J05_RS13735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1J05_RS13750	COG0275	rRNA processing
C1J05_RS13755	COG2001	Belongs to the MraZ family
C1J05_RS13760	COG0489	protein tyrosine kinase activity
C1J05_RS13775	COG0210	DNA helicase
C1J05_RS13785	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C1J05_RS13795	COG3039	Transposase
C1J05_RS13800	COG1216	Glycosyl transferase, family 2
C1J05_RS13800	COG0463	Glycosyl transferase, family 2
C1J05_RS13825	COG3283	Transcriptional regulator of aromatic amino acids metabolism
C1J05_RS13835	COG3842	ATPase activity
C1J05_RS13840	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J05_RS13845	COG1177	transmembrane transport
C1J05_RS13850	COG1012	belongs to the aldehyde dehydrogenase family
C1J05_RS13870	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1J05_RS13905	COG0131	Imidazoleglycerol-phosphate dehydratase
C1J05_RS13910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1J05_RS13925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1J05_RS13930	COG1238	metal cluster binding
C1J05_RS13935	COG0107	imidazoleglycerol-phosphate synthase activity
C1J05_RS13940	COG0140	phosphoribosyl-ATP diphosphatase activity
C1J05_RS13945	COG1832	CoA-binding protein
C1J05_RS13955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1J05_RS13975	COG4974	Belongs to the 'phage' integrase family
C1J05_RS14015	COG4681	YaeQ
C1J05_RS14020	COG1393	Belongs to the ArsC family
C1J05_RS14025	COG1162	GTPase activity
C1J05_RS14035	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C1J05_RS14055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1J05_RS14060	COG0459	protein refolding
C1J05_RS14150	COG3239	Fatty acid desaturase
C1J05_RS14160	COG1024	Enoyl-CoA hydratase
C1J05_RS14170	COG3119	arylsulfatase activity
C1J05_RS14200	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C1J05_RS14230	COG1346	cytolysis
C1J05_RS14235	COG1380	Effector of murein hydrolase LrgA
C1J05_RS14255	COG0154	amidase activity
C1J05_RS14270	COG2084	Dehydrogenase
C1J05_RS14320	COG2072	flavoprotein involved in K transport
C1J05_RS14330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1J05_RS14345	COG2873	o-acetylhomoserine
C1J05_RS14375	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1J05_RS14380	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1J05_RS14385	COG1329	Transcriptional regulator
C1J05_RS14390	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1J05_RS14395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C1J05_RS14425	COG1793	dna ligase
C1J05_RS14435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1J05_RS14455	COG0564	pseudouridine synthase activity
C1J05_RS14505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1J05_RS14510	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1J05_RS14515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1J05_RS14515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1J05_RS14520	COG3938	Belongs to the proline racemase family
C1J05_RS14535	COG1596	polysaccharide export
C1J05_RS14545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1J05_RS14545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1J05_RS14550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1J05_RS14575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1J05_RS14580	COG0358	DNA primase activity
C1J05_RS14595	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J05_RS14595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J05_RS14605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J05_RS14615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1J05_RS14655	COG1741	Belongs to the pirin family
C1J05_RS14680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1J05_RS14690	COG3447	MASE1 domain protein
C1J05_RS14690	COG5002	protein histidine kinase activity
C1J05_RS14690	COG5001	Diguanylate cyclase
C1J05_RS14775	COG0824	Thioesterase
C1J05_RS14775	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J05_RS14785	COG3246	L-lysine catabolic process to acetate
C1J05_RS14795	COG0667	Aldo Keto reductase
C1J05_RS14815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1J05_RS14840	COG1522	sequence-specific DNA binding
C1J05_RS14855	COG0483	inositol monophosphate 1-phosphatase activity
C1J05_RS14860	COG2130	NADP-dependent
C1J05_RS14865	COG0583	DNA-binding transcription factor activity
C1J05_RS14905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1J05_RS14915	COG1492	cobalamin metabolic process
C1J05_RS14930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1J05_RS14980	COG5002	protein histidine kinase activity
C1J05_RS14985	COG2197	response regulator
C1J05_RS15010	COG0583	DNA-binding transcription factor activity
C1J05_RS15020	COG0747	negative chemotaxis
C1J05_RS15025	COG0601	transmembrane transport
C1J05_RS15030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J05_RS15035	COG0444	Belongs to the ABC transporter superfamily
C1J05_RS15040	COG4608	Belongs to the ABC transporter superfamily
C1J05_RS15045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1J05_RS15055	COG0402	S-adenosylhomocysteine deaminase activity
C1J05_RS15060	COG0402	S-adenosylhomocysteine deaminase activity
C1J05_RS15090	COG0697	spore germination
C1J05_RS15115	COG2986	histidine ammonia-lyase
C1J05_RS15135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1J05_RS15150	COG0527	aspartate kinase activity
C1J05_RS15175	COG0725	ABC transporter, periplasmic molybdate-binding protein
C1J05_RS15180	COG4149	molybdate abc transporter
C1J05_RS15200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1J05_RS15205	COG1017	nitric oxide dioxygenase activity
C1J05_RS15205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1J05_RS15210	COG0659	secondary active sulfate transmembrane transporter activity
C1J05_RS15215	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C1J05_RS15220	COG1280	lysine exporter protein (LysE YggA)
C1J05_RS15225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1J05_RS15230	COG0277	FAD linked oxidase domain protein
C1J05_RS15245	COG0612	Peptidase, M16
C1J05_RS15255	COG3346	SURF1 family
C1J05_RS15265	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C1J05_RS15270	COG0109	protoheme IX farnesyltransferase activity
C1J05_RS15280	COG0312	modulator of DNA gyrase
C1J05_RS15315	COG1754	DNA topoisomerase type I activity
C1J05_RS15315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1J05_RS15355	COG4964	Belongs to the GSP D family
C1J05_RS15410	COG1201	RNA secondary structure unwinding
C1J05_RS15430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1J05_RS15435	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1J05_RS15445	COG4106	trans-aconitate 2-methyltransferase activity
C1J05_RS15450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1J05_RS15455	COG0037	tRNA processing
C1J05_RS15465	COG2885	chlorophyll binding
C1J05_RS15470	COG0823	Involved in the tonB-independent uptake of proteins
C1J05_RS15490	COG0824	Thioesterase
C1J05_RS15500	COG2255	four-way junction helicase activity
C1J05_RS15505	COG0632	four-way junction helicase activity
C1J05_RS15510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1J05_RS15540	COG2391	methyltransferase activity
C1J05_RS15550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1J05_RS15565	COG1183	phosphatidylcholine synthase activity
C1J05_RS15585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1J05_RS15595	COG3768	UPF0283 membrane protein
C1J05_RS15605	COG3106	COG3106 Predicted ATPase
C1J05_RS15610	COG0101	tRNA pseudouridine synthase activity
C1J05_RS15635	COG0584	glycerophosphoryl diester phosphodiesterase
C1J05_RS15650	COG2423	ornithine cyclodeaminase activity
C1J05_RS15655	COG3616	Alanine racemase, N-terminal domain
C1J05_RS15660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1J05_RS15665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1J05_RS15670	COG1414	Transcriptional regulator
C1J05_RS15680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1J05_RS15690	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1J05_RS15705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1J05_RS15710	COG1396	sequence-specific DNA binding
C1J05_RS15740	COG0410	ABC transporter
C1J05_RS15785	COG5328	Belongs to the UPF0262 family
C1J05_RS15790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1J05_RS15805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1J05_RS15835	COG3039	Transposase
C1J05_RS15865	COG0259	pyridoxamine-phosphate oxidase activity
C1J05_RS15870	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1J05_RS15875	COG1280	lysine exporter protein (LysE YggA)
C1J05_RS15880	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C1J05_RS15895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1J05_RS15900	COG0583	DNA-binding transcription factor activity
C1J05_RS15905	COG2175	clavaminate synthase activity
C1J05_RS15920	COG2135	peptidase activity
C1J05_RS15925	COG0457	Tetratricopeptide repeat
C1J05_RS15930	COG0737	Belongs to the 5'-nucleotidase family
C1J05_RS15940	COG0167	dihydroorotate dehydrogenase activity
C1J05_RS15945	COG1393	Belongs to the ArsC family
C1J05_RS15950	COG0534	Mate efflux family protein
C1J05_RS15970	COG0789	Transcriptional regulator
C1J05_RS15975	COG1960	acyl-CoA dehydrogenase activity
C1J05_RS15985	COG1960	acyl-CoA dehydrogenase activity
C1J05_RS15995	COG0183	Belongs to the thiolase family
C1J05_RS16000	COG1024	Enoyl-CoA hydratase
C1J05_RS16000	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J05_RS16020	COG0318	PFAM AMP-dependent synthetase and ligase
C1J05_RS16035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1J05_RS16040	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C1J05_RS16050	COG0295	cytidine deaminase activity
C1J05_RS16060	COG0281	malic enzyme
C1J05_RS16060	COG0280	phosphate acetyltransferase
C1J05_RS16070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1J05_RS16075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1J05_RS16085	COG0596	Alpha beta hydrolase
C1J05_RS16105	COG0481	GTPase activity
C1J05_RS16120	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C1J05_RS16125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1J05_RS16130	COG0583	DNA-binding transcription factor activity
C1J05_RS16135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1J05_RS16150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1J05_RS16155	COG1703	isobutyryl-CoA mutase activity
C1J05_RS16160	COG1643	Atp-dependent helicase
C1J05_RS16165	COG0110	maltose O-acetyltransferase activity
C1J05_RS16170	COG0028	Belongs to the TPP enzyme family
C1J05_RS16175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1J05_RS16180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1J05_RS16205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J05_RS16220	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C1J05_RS16225	COG2943	transferase activity, transferring hexosyl groups
C1J05_RS16260	COG0825	malonyl-CoA metabolic process
C1J05_RS16265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J05_RS16280	COG1802	Transcriptional regulator
C1J05_RS16310	COG0778	Nitroreductase
C1J05_RS16315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1J05_RS16330	COG1053	succinate dehydrogenase
C1J05_RS16340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J05_RS16395	COG4948	Mandelate Racemase Muconate Lactonizing
C1J05_RS16420	COG3524	carbohydrate:proton symporter activity
C1J05_RS16425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1J05_RS16430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1J05_RS16440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1J05_RS16485	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C1J05_RS16505	COG0679	Auxin Efflux Carrier
C1J05_RS16510	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C1J05_RS16515	COG1671	Belongs to the UPF0178 family
C1J05_RS16525	COG2423	ornithine cyclodeaminase activity
C1J05_RS16535	COG2271	Major facilitator Superfamily
C1J05_RS16540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1J05_RS16545	COG0285	dihydrofolate synthase activity
C1J05_RS16550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1J05_RS16555	COG1266	CAAX protease self-immunity
C1J05_RS16560	COG2274	protein secretion by the type I secretion system
C1J05_RS16565	COG0129	dihydroxy-acid dehydratase activity
C1J05_RS16590	COG0587	DNA-directed DNA polymerase activity
C1J05_RS16595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1J05_RS16605	COG0793	Belongs to the peptidase S41A family
C1J05_RS16610	COG0778	Nitroreductase
C1J05_RS16625	COG0346	lactoylglutathione lyase activity
C1J05_RS16640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1J05_RS16645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1J05_RS16650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1J05_RS16675	COG1435	thymidine kinase activity
C1J05_RS16680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1J05_RS16685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1J05_RS16705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1J05_RS16715	COG1496	oxidoreductase activity
C1J05_RS16725	COG1522	sequence-specific DNA binding
C1J05_RS16730	COG0492	ferredoxin-NADP+ reductase activity
C1J05_RS16735	COG0529	Catalyzes the synthesis of activated sulfate
C1J05_RS16735	COG2046	Belongs to the sulfate adenylyltransferase family
C1J05_RS16740	COG0318	PFAM AMP-dependent synthetase and ligase
C1J05_RS16755	COG0071	Belongs to the small heat shock protein (HSP20) family
C1J05_RS16765	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1J05_RS16770	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1J05_RS16775	COG3454	Phosphonate metabolism
C1J05_RS16785	COG2816	NAD+ diphosphatase activity
C1J05_RS16800	COG0459	protein refolding
C1J05_RS16805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1J05_RS16820	COG1227	inorganic diphosphatase activity
C1J05_RS16840	COG2030	dehydratase
C1J05_RS16845	COG0196	riboflavin kinase activity
C1J05_RS16850	COG2983	Belongs to the UPF0260 family
C1J05_RS16895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1J05_RS16900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1J05_RS16905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1J05_RS16910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1J05_RS16915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1J05_RS16925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1J05_RS16935	COG0488	(ABC) transporter
C1J05_RS16945	COG0583	DNA-binding transcription factor activity
C1J05_RS16960	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C1J05_RS16975	COG0287	Prephenate dehydrogenase
C1J05_RS16980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1J05_RS16985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1J05_RS17005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1J05_RS17015	COG0124	histidyl-tRNA synthetase
C1J05_RS17040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1J05_RS17050	COG3845	ABC transporter
C1J05_RS17055	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1J05_RS17060	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1J05_RS17070	COG1183	phosphatidylcholine synthase activity
C1J05_RS17105	COG0277	FAD linked oxidase domain protein
C1J05_RS17110	COG0405	Gamma-glutamyltransferase
C1J05_RS17125	COG0596	Alpha beta hydrolase
C1J05_RS17130	COG1063	alcohol dehydrogenase
C1J05_RS17135	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1J05_RS17135	COG3264	Mechanosensitive ion channel
C1J05_RS17150	COG2207	Transcriptional regulator
C1J05_RS17160	COG3039	Transposase
C1J05_RS17175	COG0318	PFAM AMP-dependent synthetase and ligase
C1J05_RS17180	COG1024	Enoyl-CoA hydratase
C1J05_RS17190	COG1832	CoA-binding protein
C1J05_RS17200	COG3391	amine dehydrogenase activity
C1J05_RS17230	COG2308	Evidence 4 Homologs of previously reported genes of
C1J05_RS17255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1J05_RS17290	COG0655	NAD(P)H dehydrogenase (quinone) activity
C1J05_RS17295	COG1902	pentaerythritol trinitrate reductase activity
C1J05_RS17295	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J05_RS17305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J05_RS17340	COG0277	FAD linked oxidase domain protein
C1J05_RS17345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1J05_RS17355	COG2358	TRAP transporter, solute receptor (TAXI family
C1J05_RS17380	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1J05_RS17385	COG4948	Mandelate Racemase Muconate Lactonizing
C1J05_RS17400	COG4638	Rieske (2fe-2S)
C1J05_RS17410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1J05_RS17420	COG0798	PFAM Bile acid sodium symporter
C1J05_RS17425	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C1J05_RS17430	COG4948	Mandelate Racemase Muconate Lactonizing
C1J05_RS17435	COG0747	negative chemotaxis
C1J05_RS17440	COG0006	proline dipeptidase activity
C1J05_RS17475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J05_RS17480	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J05_RS17490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J05_RS17500	COG2111	Na H antiporter
C1J05_RS17500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1J05_RS17505	COG1006	Multisubunit Na H antiporter MnhC subunit
C1J05_RS17510	COG0651	ATP synthesis coupled electron transport
C1J05_RS17515	COG1863	multisubunit Na H antiporter MnhE subunit
C1J05_RS17520	COG2212	antiporter activity
C1J05_RS17525	COG1320	monovalent cation:proton antiporter activity
C1J05_RS17535	COG1376	ErfK ybiS ycfS ynhG family protein
C1J05_RS17540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1J05_RS17545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J05_RS17550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J05_RS17555	COG1116	anion transmembrane transporter activity
C1J05_RS17580	COG1309	transcriptional regulator
C1J05_RS17595	COG0493	'glutamate synthase
C1J05_RS17600	COG1278	Cold shock
C1J05_RS17605	COG2755	lipolytic protein G-D-S-L family
C1J05_RS17610	COG1136	(ABC) transporter
C1J05_RS17620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1J05_RS17620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1J05_RS17625	COG0509	glycine decarboxylation via glycine cleavage system
C1J05_RS17630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J05_RS17645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1J05_RS17655	COG1234	tRNA 3'-trailer cleavage
C1J05_RS17685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1J05_RS17705	COG0768	penicillin binding
C1J05_RS17710	COG0772	Belongs to the SEDS family
C1J05_RS17715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1J05_RS17730	COG3842	ATPase activity
C1J05_RS17735	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J05_RS17740	COG1177	transmembrane transport
C1J05_RS17750	COG1228	amidohydrolase
C1J05_RS17755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1J05_RS17760	COG0756	dUTP diphosphatase activity
C1J05_RS17825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1J05_RS17830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1J05_RS17850	COG2826	transposase and inactivated derivatives, IS30 family
C1J05_RS17915	COG0606	chelatase, subunit chli
C1J05_RS17930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1J05_RS17940	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1J05_RS17955	COG0180	Tryptophanyl-tRNA synthetase
C1J05_RS17960	COG2514	catechol 2,3-dioxygenase activity
C1J05_RS17975	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1J05_RS17980	COG1214	PFAM Peptidase M22, glycoprotease
C1J05_RS17990	COG1744	ABC transporter substrate-binding protein PnrA-like
C1J05_RS17995	COG3845	ABC transporter
C1J05_RS18000	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1J05_RS18005	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1J05_RS18010	COG0730	response to heat
C1J05_RS18020	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS18025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1J05_RS18040	COG3039	Transposase
C1J05_RS18045	COG0604	alcohol dehydrogenase
C1J05_RS18050	COG2937	Belongs to the GPAT DAPAT family
C1J05_RS18055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J05_RS18055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J05_RS18060	COG3039	Transposase
C1J05_RS18070	COG0813	purine-nucleoside phosphorylase activity
C1J05_RS18120	COG2030	dehydratase
C1J05_RS18135	COG2301	Belongs to the HpcH HpaI aldolase family
C1J05_RS18150	COG0039	L-malate dehydrogenase activity
C1J05_RS18155	COG0045	succinate-CoA ligase (ADP-forming) activity
C1J05_RS18165	COG0567	Dehydrogenase, E1 component
C1J05_RS18170	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J05_RS18185	COG3047	cAMP biosynthetic process
C1J05_RS18185	COG2885	chlorophyll binding
C1J05_RS18205	COG2884	Cell division ATP-binding protein ftsE
C1J05_RS18220	COG0019	diaminopimelate decarboxylase activity
C1J05_RS18235	COG3039	Transposase
C1J05_RS18250	COG0165	Argininosuccinate lyase
C1J05_RS18255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1J05_RS18260	COG0519	Catalyzes the synthesis of GMP from XMP
C1J05_RS18265	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C1J05_RS18275	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS18280	COG0583	DNA-binding transcription factor activity
C1J05_RS18295	COG2264	protein methyltransferase activity
C1J05_RS18305	COG0142	geranyltranstransferase activity
C1J05_RS18310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1J05_RS18325	COG0789	Transcriptional regulator
C1J05_RS18335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1J05_RS18345	COG0303	'Molybdopterin
C1J05_RS18350	COG1763	Mo-molybdopterin cofactor biosynthetic process
C1J05_RS18355	COG0746	molybdenum cofactor guanylyltransferase activity
C1J05_RS18360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1J05_RS18395	COG1960	acyl-CoA dehydrogenase activity
C1J05_RS18400	COG0009	L-threonylcarbamoyladenylate synthase
C1J05_RS18405	COG1678	Uncharacterized ACR, COG1678
C1J05_RS18415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1J05_RS18425	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1J05_RS18430	COG1280	lysine exporter protein (LysE YggA)
C1J05_RS18435	COG1573	uracil-dna glycosylase
C1J05_RS18440	COG0540	Belongs to the ATCase OTCase family
C1J05_RS18455	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1J05_RS18485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1J05_RS18500	COG0314	molybdopterin synthase activity
C1J05_RS18510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1J05_RS18520	COG0322	excinuclease ABC activity
C1J05_RS18525	COG1028	Short-chain dehydrogenase reductase Sdr
C1J05_RS18545	COG0842	Transport permease protein
C1J05_RS18550	COG1131	(ABC) transporter
C1J05_RS18565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1J05_RS18575	COG0156	8-amino-7-oxononanoate synthase activity
C1J05_RS18595	COG1845	cytochrome c oxidase, subunit III
C1J05_RS18605	COG0714	Associated with various cellular activities
C1J05_RS18625	COG0348	domain, Protein
C1J05_RS18625	COG3901	Regulator of nitric oxide reductase transcription
C1J05_RS18630	COG2010	Cytochrome c
C1J05_RS18635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1J05_RS18640	COG2010	Cytochrome c
C1J05_RS18645	COG3391	amine dehydrogenase activity
C1J05_RS18650	COG1522	sequence-specific DNA binding
C1J05_RS18665	COG0535	radical SAM domain protein
C1J05_RS18710	COG3852	Histidine kinase
C1J05_RS18715	COG2204	response regulator
C1J05_RS18720	COG2864	formate dehydrogenase
C1J05_RS18725	COG0437	4 iron, 4 sulfur cluster binding
C1J05_RS18730	COG3383	formate dehydrogenase (NAD+) activity
C1J05_RS18730	COG0243	molybdopterin cofactor binding
C1J05_RS18740	COG3381	protein complex oligomerization
C1J05_RS18770	COG0489	protein tyrosine kinase activity
C1J05_RS18785	COG0277	FAD linked oxidase domain protein
C1J05_RS18795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1J05_RS18800	COG1012	belongs to the aldehyde dehydrogenase family
C1J05_RS18810	COG5598	trimethylamine methyltransferase
C1J05_RS18830	COG3119	arylsulfatase activity
C1J05_RS18840	COG0714	Associated with various cellular activities
C1J05_RS18870	COG0402	S-adenosylhomocysteine deaminase activity
C1J05_RS18875	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1J05_RS18880	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1J05_RS18885	COG3845	ABC transporter
C1J05_RS18900	COG0729	surface antigen
C1J05_RS18925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1J05_RS18935	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C1J05_RS18955	COG1960	acyl-CoA dehydrogenase activity
C1J05_RS18960	COG0183	Belongs to the thiolase family
C1J05_RS18965	COG1024	Enoyl-CoA hydratase
C1J05_RS18965	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J05_RS18980	COG0747	negative chemotaxis
C1J05_RS18985	COG0601	transmembrane transport
C1J05_RS18990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J05_RS19005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1J05_RS19010	COG1840	ABC-type Fe3 transport system, periplasmic component
C1J05_RS19025	COG1178	ABC-type Fe3 transport system permease component
C1J05_RS19050	COG0559	Belongs to the binding-protein-dependent transport system permease family
C1J05_RS19065	COG4191	Histidine kinase
C1J05_RS19080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J05_RS19085	COG1116	anion transmembrane transporter activity
C1J05_RS19100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J05_RS19110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1J05_RS19115	COG0028	Belongs to the TPP enzyme family
C1J05_RS19120	COG0280	phosphate acetyltransferase
C1J05_RS19125	COG0243	molybdopterin cofactor binding
C1J05_RS19130	COG0437	4 iron, 4 sulfur cluster binding
C1J05_RS19140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1J05_RS19145	COG0741	lytic transglycosylase activity
C1J05_RS19155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J05_RS19155	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C1J05_RS19165	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C1J05_RS19175	COG0431	NADPH-dependent FMN reductase
C1J05_RS19190	COG2226	methyltransferase
C1J05_RS19200	COG2885	chlorophyll binding
C1J05_RS19205	COG2169	Transcriptional regulator
C1J05_RS19205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1J05_RS19210	COG3135	benzoate transporter
C1J05_RS19215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1J05_RS19220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1J05_RS19230	COG1051	belongs to the nudix hydrolase family
C1J05_RS19235	COG1902	pentaerythritol trinitrate reductase activity
C1J05_RS19235	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J05_RS19275	COG2226	methyltransferase
C1J05_RS19290	COG0583	DNA-binding transcription factor activity
C1J05_RS19310	COG1058	Belongs to the CinA family
C1J05_RS19310	COG1546	Belongs to the CinA family
C1J05_RS19315	COG1489	DNA binding
C1J05_RS19320	COG0024	Methionine aminopeptidase
C1J05_RS19335	COG0742	ribosomal rna small subunit methyltransferase
C1J05_RS19345	COG0678	peroxiredoxin activity
C1J05_RS19350	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1J05_RS19385	COG0347	Belongs to the P(II) protein family
C1J05_RS19390	COG0004	ammonium transporteR
C1J05_RS19400	COG0583	DNA-binding transcription factor activity
C1J05_RS19410	COG2897	thiosulfate sulfurtransferase activity
C1J05_RS19420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1J05_RS19425	COG2951	lytic endotransglycosylase activity
C1J05_RS19490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J05_RS19495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1J05_RS19505	COG1194	a g-specific adenine glycosylase
C1J05_RS19560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1J05_RS19580	COG1309	transcriptional regulator
C1J05_RS19595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J05_RS19600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J05_RS19615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1J05_RS19620	COG3842	ATPase activity
C1J05_RS19625	COG1177	transmembrane transport
C1J05_RS19630	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J05_RS19635	COG4638	Rieske (2fe-2S)
C1J05_RS19645	COG1609	Transcriptional regulator
C1J05_RS19650	COG3214	Protein conserved in bacteria
C1J05_RS19660	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
C1J05_RS19665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1J05_RS19695	COG0582	viral genome integration into host DNA
C1J05_RS19760	COG1442	glycosyl transferase family 8
C1J05_RS19795	COG1968	undecaprenyl-diphosphatase activity
C1J05_RS19820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1J05_RS19830	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1J05_RS19840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1J05_RS19870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1J05_RS19875	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C1J05_RS19895	COG1960	acyl-CoA dehydrogenase activity
C1J05_RS19920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1J05_RS19925	COG0142	geranyltranstransferase activity
C1J05_RS19930	COG1722	exodeoxyribonuclease VII activity
C1J05_RS19935	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1J05_RS19940	COG0745	RESPONSE REGULATOR receiver
C1J05_RS19945	COG1846	Transcriptional regulator
C1J05_RS19950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1J05_RS19965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1J05_RS19970	COG4143	(ABC) transporter
C1J05_RS19975	COG1178	ABC-type Fe3 transport system permease component
C1J05_RS19980	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1J05_RS19990	COG2808	Putative FMN-binding domain
C1J05_RS19995	COG0625	glutathione transferase activity
C1J05_RS20015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1J05_RS20020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1J05_RS20025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1J05_RS20045	COG2826	transposase and inactivated derivatives, IS30 family
C1J05_RS20065	COG2826	transposase and inactivated derivatives, IS30 family
C1J05_RS20070	COG0583	DNA-binding transcription factor activity
C1J05_RS20090	COG2226	methyltransferase
C1J05_RS20135	COG3293	Transposase
C1J05_RS20210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1J05_RS20215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1J05_RS20215	COG0189	ligase activity
C1J05_RS20245	COG3119	arylsulfatase activity
C1J05_RS20280	COG0489	protein tyrosine kinase activity
C1J05_RS20290	COG3267	Type II secretory pathway component ExeA
C1J05_RS20290	COG3409	Peptidoglycan-binding domain 1 protein
C1J05_RS20305	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1J05_RS20325	COG1137	ATPase activity
C1J05_RS20330	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1J05_RS20335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1J05_RS20360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1J05_RS20375	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1J05_RS20380	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1J05_RS20395	COG0443	Heat shock 70 kDa protein
C1J05_RS20400	COG0484	heat shock protein binding
C1J05_RS20405	COG2003	Belongs to the UPF0758 family
C1J05_RS20420	COG0653	protein targeting
C1J05_RS20425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1J05_RS20430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1J05_RS20435	COG0494	nUDIX hydrolase
C1J05_RS20445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1J05_RS20460	COG0779	Required for maturation of 30S ribosomal subunits
C1J05_RS20475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1J05_RS20485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1J05_RS20525	COG3034	peptidoglycan biosynthetic process
C1J05_RS20540	COG1132	(ABC) transporter
C1J05_RS20545	COG1132	(ABC) transporter
C1J05_RS20550	COG0617	tRNA 3'-terminal CCA addition
C1J05_RS20580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1J05_RS20590	COG0137	argininosuccinate synthase activity
C1J05_RS20605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1J05_RS20610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1J05_RS20610	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1J05_RS20615	COG0281	malic enzyme
C1J05_RS20615	COG0280	phosphate acetyltransferase
C1J05_RS20620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1J05_RS20625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1J05_RS20635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1J05_RS20640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1J05_RS20645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1J05_RS20660	COG0357	Ribosomal RNA small subunit methyltransferase G
C1J05_RS20665	COG0445	tRNA wobble uridine modification
C1J05_RS20670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1J05_RS20675	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1J05_RS20680	COG1981	membrane
C1J05_RS20685	COG0424	maF-like protein
C1J05_RS20690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1J05_RS20695	COG0237	dephospho-CoA kinase activity
C1J05_RS20700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1J05_RS20705	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C1J05_RS20740	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1J05_RS20745	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C1J05_RS20760	COG1074	ATP-dependent DNA helicase activity
C1J05_RS20770	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1J05_RS20775	COG3178	'Phosphotransferase
C1J05_RS20780	COG0802	atpase or kinase
C1J05_RS20795	COG1999	signal sequence binding
C1J05_RS20800	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C1J05_RS20810	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1J05_RS20815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1J05_RS20845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1J05_RS20850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1J05_RS20870	COG1360	Flagellar Motor Protein
C1J05_RS20905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1J05_RS20910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J05_RS20915	COG1177	transmembrane transport
C1J05_RS20920	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J05_RS20925	COG3842	ATPase activity
C1J05_RS20945	COG2951	lytic endotransglycosylase activity
C1J05_RS20955	COG0557	exoribonuclease II activity
C1J05_RS20965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J05_RS20980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1J05_RS20990	COG2171	N-acyltransferase activity
C1J05_RS21010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1J05_RS21035	COG0640	Transcriptional regulator
C1J05_RS21040	COG3830	Belongs to the UPF0237 family
C1J05_RS21040	COG0560	Phosphoserine phosphatase
C1J05_RS21045	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1J05_RS21050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1J05_RS21055	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1J05_RS21060	COG1063	alcohol dehydrogenase
C1J05_RS21065	COG0156	8-amino-7-oxononanoate synthase activity
C1J05_RS21070	COG1396	sequence-specific DNA binding
C1J05_RS21075	COG0183	Belongs to the thiolase family
C1J05_RS21095	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1J05_RS21115	COG0438	transferase activity, transferring glycosyl groups
C1J05_RS21130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1J05_RS21165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1J05_RS21170	COG0489	protein tyrosine kinase activity
C1J05_RS21170	COG3206	protein involved in exopolysaccharide biosynthesis
C1J05_RS21185	COG2226	methyltransferase
C1J05_RS21190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1J05_RS21200	COG0268	Binds directly to 16S ribosomal RNA