locus-tag	class	description
K3757_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K3757_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K3757_RS00040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K3757_RS00045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K3757_RS00065	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K3757_RS00075	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K3757_RS00085	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K3757_RS00090	COG1999	signal sequence binding
K3757_RS00110	COG3178	'Phosphotransferase
K3757_RS00115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K3757_RS00120	COG2887	Belongs to the helicase family. UvrD subfamily
K3757_RS00140	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K3757_RS00145	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K3757_RS00175	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K3757_RS00180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K3757_RS00185	COG0237	dephospho-CoA kinase activity
K3757_RS00190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K3757_RS00195	COG0424	maF-like protein
K3757_RS00200	COG1981	membrane
K3757_RS00205	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K3757_RS00210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K3757_RS00215	COG0445	tRNA wobble uridine modification
K3757_RS00220	COG0357	Ribosomal RNA small subunit methyltransferase G
K3757_RS00235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3757_RS00240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K3757_RS00245	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K3757_RS00250	COG1420	regulation of RNA biosynthetic process
K3757_RS00255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K3757_RS00260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K3757_RS00270	COG0280	phosphate acetyltransferase
K3757_RS00270	COG0281	malic enzyme
K3757_RS00280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3757_RS00295	COG0137	argininosuccinate synthase activity
K3757_RS00300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3757_RS00305	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS00310	COG2198	Histidine kinase
K3757_RS00315	COG0745	RESPONSE REGULATOR receiver
K3757_RS00320	COG0494	nUDIX hydrolase
K3757_RS00325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K3757_RS00330	COG0494	nUDIX hydrolase
K3757_RS00335	COG0617	tRNA 3'-terminal CCA addition
K3757_RS00340	COG1132	(ABC) transporter
K3757_RS00345	COG1132	(ABC) transporter
K3757_RS00355	COG3034	peptidoglycan biosynthetic process
K3757_RS00395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K3757_RS00405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K3757_RS00420	COG0779	Required for maturation of 30S ribosomal subunits
K3757_RS00435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K3757_RS00440	COG0494	nUDIX hydrolase
K3757_RS00445	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K3757_RS00450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K3757_RS00455	COG0653	protein targeting
K3757_RS00470	COG2003	Belongs to the UPF0758 family
K3757_RS00475	COG0484	heat shock protein binding
K3757_RS00480	COG0443	Heat shock 70 kDa protein
K3757_RS00500	COG1218	3'(2'),5'-bisphosphate nucleotidase
K3757_RS00535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3757_RS00540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K3757_RS00545	COG1137	ATPase activity
K3757_RS00565	COG3327	negative regulation of DNA-templated transcription, initiation
K3757_RS00570	COG3608	succinylglutamate desuccinylase aspartoacylase
K3757_RS00575	COG0006	proline dipeptidase activity
K3757_RS00580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3757_RS00600	COG1175	transmembrane transport
K3757_RS00605	COG0395	ABC-type sugar transport system, permease component
K3757_RS00610	COG3842	ATPase activity
K3757_RS00615	COG0837	glucose binding
K3757_RS00625	COG2095	MarC family integral membrane protein
K3757_RS00630	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K3757_RS00635	COG3474	cytochrome
K3757_RS00645	COG2130	NADP-dependent
K3757_RS00660	COG1960	acyl-CoA dehydrogenase activity
K3757_RS00665	COG1960	acyl-CoA dehydrogenase activity
K3757_RS00675	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS00680	COG0183	Belongs to the thiolase family
K3757_RS00735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3757_RS00740	COG1946	Acyl-CoA thioesterase
K3757_RS00750	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS00765	COG1024	Enoyl-CoA hydratase
K3757_RS00770	COG1024	Enoyl-CoA hydratase
K3757_RS00770	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3757_RS00780	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K3757_RS00785	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K3757_RS00785	COG0517	IMP dehydrogenase activity
K3757_RS00805	COG0181	hydroxymethylbilane synthase activity
K3757_RS00810	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K3757_RS00815	COG3268	Saccharopine dehydrogenase
K3757_RS00850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K3757_RS00860	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K3757_RS00870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3757_RS00875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3757_RS00880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3757_RS00885	COG0386	Belongs to the glutathione peroxidase family
K3757_RS00905	COG0776	regulation of translation
K3757_RS00910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K3757_RS00920	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K3757_RS00935	COG1960	acyl-CoA dehydrogenase activity
K3757_RS00955	COG1596	polysaccharide export
K3757_RS00970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3757_RS01000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K3757_RS01005	COG0142	geranyltranstransferase activity
K3757_RS01010	COG1722	exodeoxyribonuclease VII activity
K3757_RS01015	COG0745	RESPONSE REGULATOR receiver
K3757_RS01020	COG1846	Transcriptional regulator
K3757_RS01025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K3757_RS01035	COG1473	amidohydrolase
K3757_RS01050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K3757_RS01055	COG4143	(ABC) transporter
K3757_RS01065	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K3757_RS01075	COG2808	Putative FMN-binding domain
K3757_RS01080	COG0625	glutathione transferase activity
K3757_RS01105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3757_RS01110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K3757_RS01130	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K3757_RS01150	COG1414	Transcriptional regulator
K3757_RS01155	COG3214	Protein conserved in bacteria
K3757_RS01160	COG1609	Transcriptional regulator
K3757_RS01185	COG3177	Filamentation induced by cAMP protein fic
K3757_RS01190	COG3093	addiction module antidote protein HigA
K3757_RS01230	COG0697	spore germination
K3757_RS01235	COG0473	3-isopropylmalate dehydrogenase activity
K3757_RS01250	COG0066	3-isopropylmalate dehydratase activity
K3757_RS01255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K3757_RS01260	COG3264	Mechanosensitive ion channel
K3757_RS01260	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3757_RS01270	COG0799	negative regulation of ribosome biogenesis
K3757_RS01275	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K3757_RS01290	COG0277	FAD linked oxidase domain protein
K3757_RS01295	COG0277	FAD linked oxidase domain protein
K3757_RS01305	COG0247	lactate metabolic process
K3757_RS01325	COG3454	Phosphonate metabolism
K3757_RS01330	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
K3757_RS01340	COG4778	phosphonate C-P lyase system protein PhnL
K3757_RS01345	COG4107	phosphonate C-P lyase system protein PhnK
K3757_RS01350	COG3627	carbon phosphorus lyase activity
K3757_RS01355	COG3626	phosphonate metabolism
K3757_RS01360	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
K3757_RS01365	COG3624	Phosphonate C-P lyase system protein PhnG
K3757_RS01370	COG2188	Transcriptional regulator
K3757_RS01380	COG3639	organic phosphonate transmembrane transporter activity
K3757_RS01385	COG3639	organic phosphonate transmembrane transporter activity
K3757_RS01390	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
K3757_RS01395	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K3757_RS01400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K3757_RS01405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K3757_RS01410	COG1012	belongs to the aldehyde dehydrogenase family
K3757_RS01470	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3757_RS01475	COG3152	Membrane
K3757_RS01490	COG3191	aminopeptidase activity
K3757_RS01495	COG0662	Cupin 2, conserved barrel domain protein
K3757_RS01505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3757_RS01540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3757_RS01545	COG2116	formate transmembrane transporter activity
K3757_RS01550	COG1295	ribonuclease BN
K3757_RS01575	COG0784	Response regulator, receiver
K3757_RS01605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3757_RS01615	COG0069	glutamate synthase activity
K3757_RS01650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3757_RS01660	COG2995	paraquat-inducible protein a
K3757_RS01665	COG3008	intermembrane lipid transfer
K3757_RS01665	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K3757_RS01675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K3757_RS01680	COG2897	thiosulfate sulfurtransferase activity
K3757_RS01690	COG0004	ammonium transporteR
K3757_RS01700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K3757_RS01710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3757_RS01730	COG2154	pterin-4-alpha-carbinolamine dehydratase
K3757_RS01735	COG0668	transmembrane transport
K3757_RS01740	COG0678	peroxiredoxin activity
K3757_RS01750	COG0742	ribosomal rna small subunit methyltransferase
K3757_RS01755	COG0024	Methionine aminopeptidase
K3757_RS01760	COG1489	DNA binding
K3757_RS01785	COG0583	DNA-binding transcription factor activity
K3757_RS01795	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3757_RS01795	COG1902	pentaerythritol trinitrate reductase activity
K3757_RS01800	COG1051	belongs to the nudix hydrolase family
K3757_RS01815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3757_RS01820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K3757_RS01825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K3757_RS01830	COG2885	chlorophyll binding
K3757_RS01845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3757_RS01850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K3757_RS01850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3757_RS01855	COG0697	spore germination
K3757_RS01860	COG0741	lytic transglycosylase activity
K3757_RS01865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3757_RS01870	COG1473	amidohydrolase
K3757_RS01880	COG0437	4 iron, 4 sulfur cluster binding
K3757_RS01885	COG2267	carboxylic ester hydrolase activity
K3757_RS01890	COG0243	molybdopterin cofactor binding
K3757_RS01900	COG0028	Belongs to the TPP enzyme family
K3757_RS01905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3757_RS01920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3757_RS01930	COG1116	anion transmembrane transporter activity
K3757_RS01935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K3757_RS01940	COG0513	Belongs to the DEAD box helicase family
K3757_RS01955	COG0587	DNA-directed DNA polymerase activity
K3757_RS01960	COG0318	PFAM AMP-dependent synthetase and ligase
K3757_RS01980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3757_RS02015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3757_RS02045	COG1136	(ABC) transporter
K3757_RS02050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3757_RS02055	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3757_RS02060	COG0022	dehydrogenase e1 component
K3757_RS02065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3757_RS02070	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS02110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K3757_RS02135	COG0517	IMP dehydrogenase activity
K3757_RS02175	COG0825	malonyl-CoA metabolic process
K3757_RS02190	COG2301	Belongs to the HpcH HpaI aldolase family
K3757_RS02200	COG4948	Mandelate Racemase Muconate Lactonizing
K3757_RS02220	COG0469	pyruvate kinase activity
K3757_RS02230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K3757_RS02235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K3757_RS02240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K3757_RS02250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3757_RS02250	COG0072	phenylalanine-tRNA ligase activity
K3757_RS02260	COG0625	glutathione transferase activity
K3757_RS02265	COG1970	mechanosensitive ion channel activity
K3757_RS02270	COG0686	Belongs to the AlaDH PNT family
K3757_RS02275	COG1522	sequence-specific DNA binding
K3757_RS02285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K3757_RS02295	COG1122	ATPase activity
K3757_RS02300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K3757_RS02305	COG1268	BioY protein
K3757_RS02310	COG0183	Belongs to the thiolase family
K3757_RS02315	COG1021	2,3-dihydroxybenzoate-AMP ligase
K3757_RS02340	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K3757_RS02345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K3757_RS02350	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K3757_RS02360	COG2321	neutral zinc metallopeptidase
K3757_RS02370	COG0737	Belongs to the 5'-nucleotidase family
K3757_RS02375	COG2816	NAD+ diphosphatase activity
K3757_RS02390	COG3474	cytochrome
K3757_RS02400	COG4174	ABC transporter (Permease)
K3757_RS02405	COG4239	(ABC) transporter, permease
K3757_RS02410	COG4172	Belongs to the ABC transporter superfamily
K3757_RS02415	COG1686	Belongs to the peptidase S11 family
K3757_RS02430	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K3757_RS02435	COG2813	Specifically methylates the guanine in position
K3757_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS02445	COG0408	coproporphyrinogen oxidase activity
K3757_RS02460	COG0402	S-adenosylhomocysteine deaminase activity
K3757_RS02465	COG2151	metal-sulfur cluster biosynthetic enzyme
K3757_RS02465	COG0489	protein tyrosine kinase activity
K3757_RS02475	COG0254	rRNA binding
K3757_RS02480	COG0335	large ribosomal subunit rRNA binding
K3757_RS02485	COG2326	polyphosphate kinase activity
K3757_RS02505	COG0336	Belongs to the RNA methyltransferase TrmD family
K3757_RS02520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K3757_RS02530	COG0778	Nitroreductase
K3757_RS02535	COG0228	four-way junction DNA binding
K3757_RS02550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K3757_RS02575	COG0356	it plays a direct role in the translocation of protons across the membrane
K3757_RS02580	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3757_RS02585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3757_RS02590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3757_RS02595	COG2186	Transcriptional regulator
K3757_RS02620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K3757_RS02635	COG0435	Glutathione S-transferase
K3757_RS02645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K3757_RS02650	COG0242	peptide deformylase activity
K3757_RS02655	COG0242	peptide deformylase activity
K3757_RS02660	COG0242	peptide deformylase activity
K3757_RS02665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K3757_RS02675	COG2860	membrane
K3757_RS02680	COG0328	RNA-DNA hybrid ribonuclease activity
K3757_RS02695	COG1280	lysine exporter protein (LysE YggA)
K3757_RS02700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K3757_RS02715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K3757_RS02715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K3757_RS02720	COG1758	RNA polymerase activity
K3757_RS02725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K3757_RS02735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K3757_RS02740	COG0736	holo-[acyl-carrier-protein] synthase activity
K3757_RS02745	COG0681	Belongs to the peptidase S26 family
K3757_RS02750	COG0571	ribonuclease III activity
K3757_RS02755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K3757_RS02765	COG1381	Involved in DNA repair and RecF pathway recombination
K3757_RS02790	COG1396	sequence-specific DNA binding
K3757_RS02805	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K3757_RS02810	COG0745	RESPONSE REGULATOR receiver
K3757_RS02815	COG2205	protein histidine kinase activity
K3757_RS02820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K3757_RS02825	COG1660	Displays ATPase and GTPase activities
K3757_RS02845	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3757_RS02860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K3757_RS02875	COG0583	DNA-binding transcription factor activity
K3757_RS02895	COG2096	Adenosyltransferase
K3757_RS02905	COG0300	oxidoreductase activity
K3757_RS02915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3757_RS02925	COG0501	Belongs to the peptidase M48B family
K3757_RS02935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3757_RS02960	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K3757_RS02965	COG0250	Participates in transcription elongation, termination and antitermination
K3757_RS02975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K3757_RS02980	COG0081	regulation of translation
K3757_RS02990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K3757_RS02995	COG0222	ribosome binding
K3757_RS03000	COG0085	RNA polymerase activity
K3757_RS03005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K3757_RS03025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K3757_RS03030	COG0049	tRNA binding
K3757_RS03035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K3757_RS03045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3757_RS03050	COG3239	Fatty acid desaturase
K3757_RS03055	COG0051	transcription antitermination factor activity, RNA binding
K3757_RS03060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K3757_RS03065	COG0088	Forms part of the polypeptide exit tunnel
K3757_RS03070	COG0089	rRNA binding
K3757_RS03075	COG1278	Cold shock
K3757_RS03090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K3757_RS03095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K3757_RS03100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K3757_RS03105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K3757_RS03110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K3757_RS03135	COG0255	Belongs to the universal ribosomal protein uL29 family
K3757_RS03140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K3757_RS03145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K3757_RS03150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K3757_RS03155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K3757_RS03160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K3757_RS03165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K3757_RS03170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K3757_RS03175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K3757_RS03180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K3757_RS03185	COG1841	ribosomal large subunit assembly
K3757_RS03195	COG0200	Binds to the 23S rRNA
K3757_RS03200	COG0201	protein transport
K3757_RS03205	COG0563	adenylate kinase activity
K3757_RS03210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K3757_RS03215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K3757_RS03220	COG0202	RNA polymerase activity
K3757_RS03225	COG0203	ribosomal protein L17
K3757_RS03230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3757_RS03235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K3757_RS03240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K3757_RS03245	COG0564	pseudouridine synthase activity
K3757_RS03250	COG0546	phosphoglycolate phosphatase activity
K3757_RS03260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3757_RS03265	COG4597	amino acid ABC transporter
K3757_RS03270	COG0765	amino acid transport
K3757_RS03275	COG1126	abc transporter atp-binding protein
K3757_RS03285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K3757_RS03290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K3757_RS03300	COG0706	membrane insertase activity
K3757_RS03310	COG0037	tRNA processing
K3757_RS03325	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K3757_RS03330	COG0594	ribonuclease P activity
K3757_RS03335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K3757_RS03345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K3757_RS03360	COG0625	glutathione transferase activity
K3757_RS03370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K3757_RS03380	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3757_RS03385	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K3757_RS03410	COG0745	RESPONSE REGULATOR receiver
K3757_RS03415	COG0642	Histidine kinase
K3757_RS03420	COG1271	oxidase subunit
K3757_RS03425	COG1294	oxidase, subunit
K3757_RS03435	COG0604	alcohol dehydrogenase
K3757_RS03435	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS03435	COG3321	synthase
K3757_RS03440	COG0697	spore germination
K3757_RS03450	COG1131	(ABC) transporter
K3757_RS03455	COG0842	Transport permease protein
K3757_RS03460	COG0616	signal peptide processing
K3757_RS03460	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K3757_RS03475	COG0322	excinuclease ABC activity
K3757_RS03480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K3757_RS03490	COG0314	molybdopterin synthase activity
K3757_RS03495	COG0589	response to stress
K3757_RS03505	COG2885	chlorophyll binding
K3757_RS03510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K3757_RS03515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K3757_RS03550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K3757_RS03555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K3757_RS03575	COG0540	Belongs to the ATCase OTCase family
K3757_RS03580	COG1573	uracil-dna glycosylase
K3757_RS03585	COG1280	lysine exporter protein (LysE YggA)
K3757_RS03590	COG0521	Mo-molybdopterin cofactor biosynthetic process
K3757_RS03610	COG1678	Uncharacterized ACR, COG1678
K3757_RS03615	COG0009	L-threonylcarbamoyladenylate synthase
K3757_RS03620	COG1960	acyl-CoA dehydrogenase activity
K3757_RS03655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K3757_RS03660	COG0746	molybdenum cofactor guanylyltransferase activity
K3757_RS03665	COG1763	Mo-molybdopterin cofactor biosynthetic process
K3757_RS03670	COG0303	'Molybdopterin
K3757_RS03685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K3757_RS03700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K3757_RS03705	COG0142	geranyltranstransferase activity
K3757_RS03725	COG0583	DNA-binding transcription factor activity
K3757_RS03745	COG0519	Catalyzes the synthesis of GMP from XMP
K3757_RS03755	COG0438	transferase activity, transferring glycosyl groups
K3757_RS03760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K3757_RS03765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3757_RS03770	COG0287	Prephenate dehydrogenase
K3757_RS03785	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
K3757_RS03810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3757_RS03820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3757_RS03825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K3757_RS03830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K3757_RS03835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K3757_RS03840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K3757_RS03860	COG0596	Alpha beta hydrolase
K3757_RS03870	COG2983	Belongs to the UPF0260 family
K3757_RS03875	COG0196	riboflavin kinase activity
K3757_RS03880	COG2030	dehydratase
K3757_RS03890	COG1227	inorganic diphosphatase activity
K3757_RS03905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K3757_RS03910	COG0459	protein refolding
K3757_RS03915	COG5002	protein histidine kinase activity
K3757_RS03940	COG3454	Phosphonate metabolism
K3757_RS03945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K3757_RS03950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K3757_RS03960	COG0071	Belongs to the small heat shock protein (HSP20) family
K3757_RS03970	COG0384	phenazine biosynthesis protein PhzF
K3757_RS03980	COG0529	Catalyzes the synthesis of activated sulfate
K3757_RS03980	COG2046	Belongs to the sulfate adenylyltransferase family
K3757_RS03985	COG0698	ribose 5-phosphate isomerase
K3757_RS03990	COG0492	ferredoxin-NADP+ reductase activity
K3757_RS03995	COG1522	sequence-specific DNA binding
K3757_RS04010	COG1496	oxidoreductase activity
K3757_RS04020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K3757_RS04040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3757_RS04045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3757_RS04050	COG1435	thymidine kinase activity
K3757_RS04060	COG0431	NADPH-dependent FMN reductase
K3757_RS04075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K3757_RS04100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K3757_RS04105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K3757_RS04110	COG3237	CsbD-like
K3757_RS04125	COG0280	phosphate acetyltransferase
K3757_RS04125	COG0281	malic enzyme
K3757_RS04140	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K3757_RS04145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K3757_RS04170	COG0318	PFAM AMP-dependent synthetase and ligase
K3757_RS04190	COG1024	Enoyl-CoA hydratase
K3757_RS04190	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3757_RS04200	COG0183	Belongs to the thiolase family
K3757_RS04205	COG0625	glutathione transferase activity
K3757_RS04225	COG1960	acyl-CoA dehydrogenase activity
K3757_RS04255	COG0534	Mate efflux family protein
K3757_RS04260	COG1393	Belongs to the ArsC family
K3757_RS04280	COG0737	Belongs to the 5'-nucleotidase family
K3757_RS04290	COG2135	peptidase activity
K3757_RS04305	COG1960	acyl-CoA dehydrogenase activity
K3757_RS04315	COG4948	Mandelate Racemase Muconate Lactonizing
K3757_RS04335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K3757_RS04360	COG1047	Peptidyl-prolyl cis-trans
K3757_RS04375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3757_RS04385	COG1012	belongs to the aldehyde dehydrogenase family
K3757_RS04390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3757_RS04395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3757_RS04400	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K3757_RS04405	COG0116	Belongs to the methyltransferase superfamily
K3757_RS04420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3757_RS04425	COG2885	chlorophyll binding
K3757_RS04435	COG1702	phosphate starvation-inducible protein PhoH
K3757_RS04440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K3757_RS04445	COG1253	flavin adenine dinucleotide binding
K3757_RS04450	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K3757_RS04455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K3757_RS04465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K3757_RS04470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K3757_RS04475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K3757_RS04495	COG0539	negative regulation of cytoplasmic translation
K3757_RS04500	COG0776	regulation of translation
K3757_RS04510	COG0135	phosphoribosylanthranilate isomerase activity
K3757_RS04515	COG0133	tryptophan synthase activity
K3757_RS04540	COG0193	aminoacyl-tRNA hydrolase activity
K3757_RS04550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K3757_RS04570	COG0159	tryptophan synthase activity
K3757_RS04575	COG0012	GTP binding
K3757_RS04595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3757_RS04605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3757_RS04610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K3757_RS04620	COG2986	histidine ammonia-lyase
K3757_RS04625	COG1228	amidohydrolase
K3757_RS04650	COG0577	efflux transmembrane transporter activity
K3757_RS04655	COG1136	(ABC) transporter
K3757_RS04655	COG0577	efflux transmembrane transporter activity
K3757_RS04670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K3757_RS04675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3757_RS04735	COG0101	tRNA pseudouridine synthase activity
K3757_RS04740	COG3106	COG3106 Predicted ATPase
K3757_RS04750	COG3768	UPF0283 membrane protein
K3757_RS04760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K3757_RS04765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K3757_RS04770	COG1183	phosphatidylcholine synthase activity
K3757_RS04775	COG4974	Belongs to the 'phage' integrase family
K3757_RS04800	COG2264	protein methyltransferase activity
K3757_RS04820	COG0632	four-way junction helicase activity
K3757_RS04825	COG2255	four-way junction helicase activity
K3757_RS04835	COG0824	Thioesterase
K3757_RS04845	COG0848	biopolymer transport protein
K3757_RS04855	COG0823	Involved in the tonB-independent uptake of proteins
K3757_RS04860	COG2885	chlorophyll binding
K3757_RS04870	COG0037	tRNA processing
K3757_RS04875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K3757_RS04890	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K3757_RS04895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3757_RS04910	COG1201	RNA secondary structure unwinding
K3757_RS04965	COG4964	Belongs to the GSP D family
K3757_RS04985	COG0741	lytic transglycosylase activity
K3757_RS04990	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K3757_RS05005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3757_RS05005	COG1754	DNA topoisomerase type I activity
K3757_RS05010	COG0758	DNA mediated transformation
K3757_RS05015	COG0312	modulator of DNA gyrase
K3757_RS05025	COG0109	protoheme IX farnesyltransferase activity
K3757_RS05035	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K3757_RS05045	COG3346	SURF1 family
K3757_RS05055	COG0612	Peptidase, M16
K3757_RS05080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K3757_RS05085	COG1280	lysine exporter protein (LysE YggA)
K3757_RS05095	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K3757_RS05100	COG0659	secondary active sulfate transmembrane transporter activity
K3757_RS05110	COG1309	transcriptional regulator
K3757_RS05115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K3757_RS05150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3757_RS05155	COG0019	diaminopimelate decarboxylase activity
K3757_RS05175	COG0667	Aldo Keto reductase
K3757_RS05205	COG0653	protein targeting
K3757_RS05235	COG1538	Outer membrane efflux protein
K3757_RS05240	COG0745	RESPONSE REGULATOR receiver
K3757_RS05260	COG0582	viral genome integration into host DNA
K3757_RS05345	COG1484	DNA-dependent DNA replication
K3757_RS05350	COG4584	PFAM Integrase catalytic
K3757_RS05400	COG0582	viral genome integration into host DNA
K3757_RS05410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K3757_RS05425	COG1492	cobalamin metabolic process
K3757_RS05435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K3757_RS05450	COG1132	(ABC) transporter
K3757_RS05455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K3757_RS05465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3757_RS05485	COG0525	valine-tRNA ligase activity
K3757_RS05520	COG1012	belongs to the aldehyde dehydrogenase family
K3757_RS05525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K3757_RS05535	COG2267	carboxylic ester hydrolase activity
K3757_RS05550	COG2130	NADP-dependent
K3757_RS05555	COG0483	inositol monophosphate 1-phosphatase activity
K3757_RS05575	COG1522	sequence-specific DNA binding
K3757_RS05585	COG1024	Enoyl-CoA hydratase
K3757_RS05590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3757_RS05600	COG0667	Aldo Keto reductase
K3757_RS05605	COG3246	L-lysine catabolic process to acetate
K3757_RS05615	COG0824	Thioesterase
K3757_RS05615	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3757_RS05620	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS05690	COG5001	Diguanylate cyclase
K3757_RS05690	COG5002	protein histidine kinase activity
K3757_RS05690	COG3447	MASE1 domain protein
K3757_RS05695	COG1802	Transcriptional regulator
K3757_RS05705	COG1012	belongs to the aldehyde dehydrogenase family
K3757_RS05710	COG1053	succinate dehydrogenase
K3757_RS05710	COG3976	FMN-binding domain protein
K3757_RS05740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3757_RS05765	COG0438	transferase activity, transferring glycosyl groups
K3757_RS05780	COG3206	protein involved in exopolysaccharide biosynthesis
K3757_RS05780	COG0489	protein tyrosine kinase activity
K3757_RS05795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K3757_RS05815	COG1741	Belongs to the pirin family
K3757_RS05855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K3757_RS05860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K3757_RS05860	COG2169	Transcriptional regulator
K3757_RS05865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3757_RS05875	COG4311	Sarcosine oxidase, delta subunit
K3757_RS05880	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3757_RS05880	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3757_RS05900	COG0358	DNA primase activity
K3757_RS05905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K3757_RS05915	COG0432	Pfam Uncharacterised protein family UPF0047
K3757_RS05925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K3757_RS05930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3757_RS05930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3757_RS05960	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K3757_RS05965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3757_RS06015	COG0564	pseudouridine synthase activity
K3757_RS06025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3757_RS06035	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K3757_RS06035	COG1793	dna ligase
K3757_RS06065	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K3757_RS06070	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K3757_RS06075	COG1329	Transcriptional regulator
K3757_RS06080	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K3757_RS06085	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K3757_RS06095	COG1522	sequence-specific DNA binding
K3757_RS06110	COG2873	o-acetylhomoserine
K3757_RS06165	COG0778	Nitroreductase
K3757_RS06170	COG1733	regulation of RNA biosynthetic process
K3757_RS06175	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K3757_RS06180	COG0602	queuosine metabolic process
K3757_RS06185	COG0720	synthase
K3757_RS06190	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K3757_RS06210	COG2894	cell division
K3757_RS06285	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
K3757_RS06285	COG1672	PFAM Archaeal ATPase
K3757_RS06305	COG0028	Belongs to the TPP enzyme family
K3757_RS06310	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3757_RS06320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K3757_RS06330	COG1832	CoA-binding protein
K3757_RS06335	COG0140	phosphoribosyl-ATP diphosphatase activity
K3757_RS06340	COG0107	imidazoleglycerol-phosphate synthase activity
K3757_RS06345	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3757_RS06355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K3757_RS06360	COG0131	Imidazoleglycerol-phosphate dehydratase
K3757_RS06380	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3757_RS06380	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3757_RS06390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3757_RS06395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3757_RS06410	COG1609	Transcriptional regulator
K3757_RS06425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3757_RS06435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K3757_RS06440	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS06470	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K3757_RS06475	COG1304	FMN binding
K3757_RS06495	COG0489	protein tyrosine kinase activity
K3757_RS06505	COG2001	Belongs to the MraZ family
K3757_RS06510	COG0275	rRNA processing
K3757_RS06525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K3757_RS06535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K3757_RS06540	COG2066	Belongs to the glutaminase family
K3757_RS06545	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K3757_RS06550	COG2081	HI0933 family
K3757_RS06565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K3757_RS06570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K3757_RS06590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K3757_RS06595	COG1181	Belongs to the D-alanine--D-alanine ligase family
K3757_RS06600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K3757_RS06605	COG0849	cell division
K3757_RS06610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K3757_RS06620	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3757_RS06625	COG0497	DNA recombination
K3757_RS06640	COG0006	proline dipeptidase activity
K3757_RS06660	COG0484	heat shock protein binding
K3757_RS06680	COG0784	Response regulator, receiver
K3757_RS06680	COG4191	Histidine kinase
K3757_RS06685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3757_RS06690	COG0318	PFAM AMP-dependent synthetase and ligase
K3757_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS06720	COG0308	aminopeptidase N
K3757_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS06760	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K3757_RS06770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3757_RS06775	COG0601	transmembrane transport
K3757_RS06785	COG4172	Belongs to the ABC transporter superfamily
K3757_RS06790	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS06805	COG1473	amidohydrolase
K3757_RS06810	COG1473	amidohydrolase
K3757_RS06815	COG0438	transferase activity, transferring glycosyl groups
K3757_RS06820	COG1519	Transferase
K3757_RS06825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K3757_RS06850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K3757_RS06855	COG0546	phosphoglycolate phosphatase activity
K3757_RS06870	COG1960	acyl-CoA dehydrogenase activity
K3757_RS06875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3757_RS06885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3757_RS06925	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3757_RS06930	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3757_RS06935	COG0649	NAD binding
K3757_RS06950	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K3757_RS06950	COG3743	rRNA binding
K3757_RS07000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K3757_RS07005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3757_RS07020	COG0713	ATP synthesis coupled electron transport
K3757_RS07035	COG1007	ATP synthesis coupled electron transport
K3757_RS07045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K3757_RS07055	COG0513	Belongs to the DEAD box helicase family
K3757_RS07065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K3757_RS07080	COG4335	DNA alkylation repair
K3757_RS07090	COG3842	ATPase activity
K3757_RS07110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K3757_RS07115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K3757_RS07120	COG0805	protein transport
K3757_RS07140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K3757_RS07145	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K3757_RS07150	COG4221	oxidoreductase activity
K3757_RS07165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K3757_RS07190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K3757_RS07205	COG0305	Participates in initiation and elongation during chromosome replication
K3757_RS07210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3757_RS07215	COG0418	dihydroorotase activity
K3757_RS07260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3757_RS07280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K3757_RS07285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K3757_RS07290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K3757_RS07305	COG1138	Cytochrome C-type biogenesis protein
K3757_RS07310	COG3088	subunit of a heme lyase
K3757_RS07315	COG1024	Enoyl-CoA hydratase
K3757_RS07330	COG0372	Belongs to the citrate synthase family
K3757_RS07335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3757_RS07340	COG0658	competence protein
K3757_RS07340	COG2333	competence protein COMEC
K3757_RS07345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K3757_RS07350	COG0303	'Molybdopterin
K3757_RS07355	COG0315	cyclic pyranopterin monophosphate synthase activity
K3757_RS07360	COG0134	indole-3-glycerol-phosphate synthase activity
K3757_RS07365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K3757_RS07370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3757_RS07390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3757_RS07405	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K3757_RS07410	COG1280	lysine exporter protein (LysE YggA)
K3757_RS07415	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K3757_RS07420	COG0259	pyridoxamine-phosphate oxidase activity
K3757_RS07425	COG1278	Cold shock
K3757_RS07440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K3757_RS07450	COG1902	pentaerythritol trinitrate reductase activity
K3757_RS07455	COG1454	alcohol dehydrogenase
K3757_RS07480	COG2391	methyltransferase activity
K3757_RS07495	COG0785	Cytochrome C biogenesis protein
K3757_RS07520	COG3258	Cytochrome c
K3757_RS07525	COG0737	Belongs to the 5'-nucleotidase family
K3757_RS07550	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3757_RS07560	COG0156	8-amino-7-oxononanoate synthase activity
K3757_RS07565	COG2391	methyltransferase activity
K3757_RS07570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3757_RS07605	COG0215	cysteine-tRNA ligase activity
K3757_RS07610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3757_RS07630	COG2814	Major facilitator Superfamily
K3757_RS07670	COG0316	Belongs to the HesB IscA family
K3757_RS07675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K3757_RS07685	COG0018	arginyl-trna synthetase
K3757_RS07695	COG1472	Belongs to the glycosyl hydrolase 3 family
K3757_RS07700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K3757_RS07705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K3757_RS07715	COG0717	Belongs to the dCTP deaminase family
K3757_RS07730	COG0776	regulation of translation
K3757_RS07735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K3757_RS07740	COG0416	fatty acid biosynthetic process
K3757_RS07745	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K3757_RS07765	COG0488	(ABC) transporter
K3757_RS07775	COG4251	negative regulation of phosphorylation
K3757_RS07785	COG0701	Predicted permease
K3757_RS07800	COG2133	pyrroloquinoline quinone binding
K3757_RS07815	COG1380	Effector of murein hydrolase LrgA
K3757_RS07820	COG1346	cytolysis
K3757_RS07825	COG0071	Belongs to the small heat shock protein (HSP20) family
K3757_RS07840	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K3757_RS07845	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K3757_RS07875	COG0148	phosphopyruvate hydratase activity
K3757_RS07895	COG0513	Belongs to the DEAD box helicase family
K3757_RS07910	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K3757_RS07930	COG3956	TIGRFAM MazG family protein
K3757_RS07935	COG1473	amidohydrolase
K3757_RS07940	COG0010	Belongs to the arginase family
K3757_RS07960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K3757_RS07965	COG2890	protein-(glutamine-N5) methyltransferase activity
K3757_RS07975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K3757_RS07980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K3757_RS07985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K3757_RS07990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K3757_RS08005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3757_RS08030	COG2095	MarC family integral membrane protein
K3757_RS08035	COG0488	(ABC) transporter
K3757_RS08040	COG0105	UTP biosynthetic process
K3757_RS08055	COG0642	Histidine kinase
K3757_RS08070	COG0688	phosphatidylethanolamine metabolic process
K3757_RS08080	COG2194	sulfuric ester hydrolase activity
K3757_RS08115	COG1309	transcriptional regulator
K3757_RS08120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3757_RS08145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3757_RS08155	COG0747	negative chemotaxis
K3757_RS08165	COG4172	Belongs to the ABC transporter superfamily
K3757_RS08180	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3757_RS08195	COG0747	negative chemotaxis
K3757_RS08205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3757_RS08220	COG0006	proline dipeptidase activity
K3757_RS08230	COG1072	(Pantothenic acid kinase))
K3757_RS08275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K3757_RS08325	COG2132	Multicopper oxidase
K3757_RS08425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K3757_RS08430	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K3757_RS08440	COG2166	iron-sulfur cluster assembly
K3757_RS08455	COG5012	cobalamin binding
K3757_RS08465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K3757_RS08470	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3757_RS08475	COG0047	phosphoribosylformylglycinamidine synthase activity
K3757_RS08485	COG2204	response regulator
K3757_RS08495	COG1530	ribonuclease E activity
K3757_RS08500	COG0425	Belongs to the sulfur carrier protein TusA family
K3757_RS08505	COG0785	Cytochrome C biogenesis protein
K3757_RS08515	COG2124	cytochrome p450
K3757_RS08520	COG3588	fructose-bisphosphate aldolase
K3757_RS08535	COG0114	fumarate hydratase activity
K3757_RS08570	COG2186	Transcriptional regulator
K3757_RS08575	COG0604	alcohol dehydrogenase
K3757_RS08585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3757_RS08590	COG0415	Belongs to the DNA photolyase family
K3757_RS08595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K3757_RS08605	COG0494	nUDIX hydrolase
K3757_RS08615	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K3757_RS08615	COG3264	Mechanosensitive ion channel
K3757_RS08620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3757_RS08675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K3757_RS08675	COG1017	nitric oxide dioxygenase activity
K3757_RS08680	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS08685	COG2207	Transcriptional regulator
K3757_RS08710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K3757_RS08725	COG0010	Belongs to the arginase family
K3757_RS08730	COG0516	GMP reductase activity
K3757_RS08730	COG0517	IMP dehydrogenase activity
K3757_RS08735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K3757_RS08735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3757_RS08750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K3757_RS08755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3757_RS08765	COG1217	gtp-binding protein TYPA
K3757_RS08770	COG2076	Multidrug Resistance protein
K3757_RS08775	COG1522	sequence-specific DNA binding
K3757_RS08785	COG0121	glutamine amidotransferase
K3757_RS08795	COG0538	isocitrate dehydrogenase activity
K3757_RS08810	COG2945	thiolester hydrolase activity
K3757_RS08815	COG1959	2 iron, 2 sulfur cluster binding
K3757_RS08820	COG1104	cysteine desulfurase activity
K3757_RS08825	COG0719	Fe-S assembly protein
K3757_RS08835	COG0393	Putative heavy-metal-binding
K3757_RS08845	COG0396	ATPase activity
K3757_RS08850	COG0719	Fe-S assembly protein
K3757_RS08865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3757_RS08875	COG0405	Gamma-glutamyltransferase
K3757_RS08890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K3757_RS08900	COG0248	Ppx GppA phosphatase
K3757_RS08905	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K3757_RS08920	COG0574	Belongs to the PEP-utilizing enzyme family
K3757_RS08920	COG3848	Pyruvate phosphate dikinase
K3757_RS08930	COG3842	ATPase activity
K3757_RS08935	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3757_RS08940	COG1177	transmembrane transport
K3757_RS08960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K3757_RS08965	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K3757_RS08970	COG4681	YaeQ
K3757_RS08985	COG2197	response regulator
K3757_RS08990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K3757_RS09000	COG0784	Response regulator, receiver
K3757_RS09000	COG5002	protein histidine kinase activity
K3757_RS09015	COG1215	transferase activity, transferring glycosyl groups
K3757_RS09020	COG1216	Glycosyl transferase, family 2
K3757_RS09020	COG1442	glycosyl transferase family 8
K3757_RS09025	COG0297	glycogen (starch) synthase activity
K3757_RS09045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K3757_RS09045	COG3743	rRNA binding
K3757_RS09050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K3757_RS09070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K3757_RS09075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K3757_RS09080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K3757_RS09105	COG0052	Belongs to the universal ribosomal protein uS2 family
K3757_RS09110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K3757_RS09115	COG2197	response regulator
K3757_RS09120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K3757_RS09125	COG0022	dehydrogenase e1 component
K3757_RS09135	COG0745	RESPONSE REGULATOR receiver
K3757_RS09145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K3757_RS09155	COG0573	inorganic phosphate transmembrane transporter activity
K3757_RS09165	COG5002	protein histidine kinase activity
K3757_RS09170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K3757_RS09175	COG0194	GDP metabolic process
K3757_RS09180	COG1561	YicC-like family, N-terminal region
K3757_RS09190	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K3757_RS09235	COG0433	COG0433 Predicted ATPase
K3757_RS09245	COG0346	lactoylglutathione lyase activity
K3757_RS09260	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3757_RS09280	COG0166	Belongs to the GPI family
K3757_RS09290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K3757_RS09320	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K3757_RS09325	COG1612	heme a metabolic process
K3757_RS09335	COG0352	thiamine-phosphate diphosphorylase activity
K3757_RS09350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3757_RS09355	COG2313	pseudouridylate synthase activity
K3757_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS09375	COG4166	transmembrane transport
K3757_RS09390	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K3757_RS09395	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K3757_RS09400	COG2814	Major facilitator Superfamily
K3757_RS09405	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K3757_RS09435	COG2084	Dehydrogenase
K3757_RS09440	COG2366	antibiotic biosynthetic process
K3757_RS09445	COG1187	pseudouridine synthase activity
K3757_RS09455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K3757_RS09460	COG1923	regulation of RNA biosynthetic process
K3757_RS09465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3757_RS09470	COG0569	domain protein
K3757_RS09475	COG2204	response regulator
K3757_RS09480	COG5000	phosphorelay sensor kinase activity
K3757_RS09485	COG2204	response regulator
K3757_RS09490	COG3852	Histidine kinase
K3757_RS09495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K3757_RS09500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K3757_RS09500	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3757_RS09510	COG1546	Belongs to the CinA family
K3757_RS09515	COG0004	ammonium transporteR
K3757_RS09525	COG2867	negative regulation of translational initiation
K3757_RS09530	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K3757_RS09540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K3757_RS09560	COG0519	Catalyzes the synthesis of GMP from XMP
K3757_RS09560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3757_RS09585	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K3757_RS09595	COG2326	polyphosphate kinase activity
K3757_RS09600	COG1309	transcriptional regulator
K3757_RS09610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K3757_RS09615	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K3757_RS09620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K3757_RS09625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3757_RS09640	COG1024	Enoyl-CoA hydratase
K3757_RS09645	COG1858	cytochrome C peroxidase
K3757_RS09650	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K3757_RS09655	COG2264	protein methyltransferase activity
K3757_RS09660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3757_RS09665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K3757_RS09680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K3757_RS09685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K3757_RS09690	COG0745	RESPONSE REGULATOR receiver
K3757_RS09700	COG0482	sulfurtransferase activity
K3757_RS09705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3757_RS09715	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K3757_RS09720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K3757_RS09730	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K3757_RS09740	COG0750	zinc metalloprotease
K3757_RS09745	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K3757_RS09755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K3757_RS09760	COG0233	cytoplasmic translational termination
K3757_RS09765	COG0528	UMP kinase activity
K3757_RS09770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K3757_RS09780	COG0601	transmembrane transport
K3757_RS09785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3757_RS09800	COG0741	lytic transglycosylase activity
K3757_RS09805	COG0629	single-stranded DNA binding
K3757_RS09815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K3757_RS09820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K3757_RS09835	COG4974	Belongs to the 'phage' integrase family
K3757_RS09845	COG4536	flavin adenine dinucleotide binding
K3757_RS09905	COG1238	metal cluster binding
K3757_RS09910	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K3757_RS09920	COG0010	Belongs to the arginase family
K3757_RS09930	COG2423	ornithine cyclodeaminase activity
K3757_RS09935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K3757_RS09945	COG0542	response to heat
K3757_RS09980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K3757_RS09995	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K3757_RS10010	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K3757_RS10015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3757_RS10025	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K3757_RS10040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K3757_RS10045	COG0028	Belongs to the TPP enzyme family
K3757_RS10050	COG0440	acetolactate synthase activity
K3757_RS10085	COG2226	methyltransferase
K3757_RS10090	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K3757_RS10095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K3757_RS10100	COG0860	N-Acetylmuramoyl-L-alanine amidase
K3757_RS10105	COG0436	Aminotransferase
K3757_RS10110	COG0501	Belongs to the peptidase M48B family
K3757_RS10145	COG0406	alpha-ribazole phosphatase activity
K3757_RS10155	COG0776	regulation of translation
K3757_RS10160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K3757_RS10170	COG3396	Phenylacetate-CoA oxygenase
K3757_RS10175	COG3460	Phenylacetate-CoA oxygenase
K3757_RS10180	COG3396	Phenylacetate-CoA oxygenase
K3757_RS10185	COG2151	metal-sulfur cluster biosynthetic enzyme
K3757_RS10190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K3757_RS10200	COG1012	belongs to the aldehyde dehydrogenase family
K3757_RS10200	COG2030	dehydratase
K3757_RS10210	COG0343	queuine tRNA-ribosyltransferase activity
K3757_RS10225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K3757_RS10230	COG2151	metal-sulfur cluster biosynthetic enzyme
K3757_RS10245	COG0316	Belongs to the HesB IscA family
K3757_RS10255	COG1418	mRNA catabolic process
K3757_RS10265	COG0149	triose-phosphate isomerase activity
K3757_RS10270	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3757_RS10275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K3757_RS10280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3757_RS10285	COG2204	response regulator
K3757_RS10295	COG2124	cytochrome p450
K3757_RS10300	COG1522	sequence-specific DNA binding
K3757_RS10305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K3757_RS10305	COG1648	precorrin-2 dehydrogenase activity
K3757_RS10315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K3757_RS10320	COG0175	sulfate reduction
K3757_RS10345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K3757_RS10350	COG2885	chlorophyll binding
K3757_RS10375	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K3757_RS10390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K3757_RS10410	COG1070	Carbohydrate kinase
K3757_RS10430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K3757_RS10440	COG2354	Protein conserved in bacteria
K3757_RS10460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K3757_RS10465	COG0516	GMP reductase activity
K3757_RS10465	COG0517	IMP dehydrogenase activity
K3757_RS10500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K3757_RS10515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K3757_RS10525	COG2814	Major facilitator Superfamily
K3757_RS10530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K3757_RS10540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K3757_RS10545	COG2833	Protein of unknown function (DUF455)
K3757_RS10550	COG0739	heme binding
K3757_RS10575	COG0126	phosphoglycerate kinase activity
K3757_RS10585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K3757_RS10590	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3757_RS10590	COG0022	dehydrogenase e1 component
K3757_RS10595	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3757_RS10680	COG4695	Portal protein
K3757_RS10690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K3757_RS10695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3757_RS10710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3757_RS10720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K3757_RS10730	COG2353	YceI-like domain
K3757_RS10740	COG0360	Binds together with S18 to 16S ribosomal RNA
K3757_RS10745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K3757_RS10750	COG0359	binds to the 23S rRNA
K3757_RS10770	COG0544	peptidyl-prolyl cis-trans isomerase activity
K3757_RS10775	COG3750	Belongs to the UPF0335 family
K3757_RS10810	COG1396	sequence-specific DNA binding
K3757_RS10810	COG3800	Transcriptional regulator
K3757_RS10820	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3757_RS10835	COG0410	ABC transporter
K3757_RS10850	COG0511	ligase activity, forming carbon-carbon bonds
K3757_RS10855	COG0439	Biotin carboxylase
K3757_RS10860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K3757_RS10880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K3757_RS10885	COG0740	serine-type endopeptidase activity
K3757_RS10905	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K3757_RS10915	COG1121	(ABC) transporter
K3757_RS10920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K3757_RS10930	COG3483	tryptophan 2,3-dioxygenase activity
K3757_RS10945	COG0582	viral genome integration into host DNA
K3757_RS11065	COG2197	response regulator
K3757_RS11080	COG0784	Response regulator, receiver
K3757_RS11080	COG2198	Histidine kinase
K3757_RS11080	COG2205	protein histidine kinase activity
K3757_RS11100	COG1024	Enoyl-CoA hydratase
K3757_RS11115	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K3757_RS11130	COG0318	PFAM AMP-dependent synthetase and ligase
K3757_RS11150	COG1216	Glycosyl transferase, family 2
K3757_RS11175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K3757_RS11175	COG2755	lipolytic protein G-D-S-L family
K3757_RS11225	COG3800	Transcriptional regulator
K3757_RS11225	COG1396	sequence-specific DNA binding
K3757_RS11235	COG0183	Belongs to the thiolase family
K3757_RS11240	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS11245	COG3243	poly(R)-hydroxyalkanoic acid synthase
K3757_RS11250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3757_RS11265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K3757_RS11280	COG2176	DNA-directed DNA polymerase activity
K3757_RS11280	COG5002	protein histidine kinase activity
K3757_RS11300	COG0318	PFAM AMP-dependent synthetase and ligase
K3757_RS11320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3757_RS11325	COG1024	Enoyl-CoA hydratase
K3757_RS11345	COG2084	Dehydrogenase
K3757_RS11360	COG0154	amidase activity
K3757_RS11390	COG0625	glutathione transferase activity
K3757_RS11435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K3757_RS11460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K3757_RS11485	COG1686	Belongs to the peptidase S11 family
K3757_RS11490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K3757_RS11500	COG0084	hydrolase, TatD family'
K3757_RS11505	COG1234	tRNA 3'-trailer cleavage
K3757_RS11550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3757_RS11555	COG0509	glycine decarboxylation via glycine cleavage system
K3757_RS11560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3757_RS11560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3757_RS11595	COG0544	peptidyl-prolyl cis-trans isomerase activity
K3757_RS11605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K3757_RS11635	COG0006	proline dipeptidase activity
K3757_RS11655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K3757_RS11670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3757_RS11695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3757_RS11705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3757_RS11710	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3757_RS11715	COG4133	protoheme IX ABC transporter activity
K3757_RS11720	COG3737	Protein of unknown function (DUF498/DUF598)
K3757_RS11730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3757_RS11735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3757_RS11740	COG1862	Preprotein translocase
K3757_RS11745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K3757_RS11760	COG1160	GTP binding
K3757_RS11780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3757_RS11790	COG5265	(ABC) transporter
K3757_RS11830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3757_RS11830	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3757_RS11845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3757_RS11855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K3757_RS11875	COG0730	response to heat
K3757_RS11880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K3757_RS11890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K3757_RS11900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K3757_RS11905	COG2205	protein histidine kinase activity
K3757_RS11910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3757_RS11910	COG2205	protein histidine kinase activity
K3757_RS11925	COG0300	oxidoreductase activity
K3757_RS11930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3757_RS11935	COG0385	Bile acid
K3757_RS11940	COG2072	flavoprotein involved in K transport
K3757_RS11950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K3757_RS11960	COG1126	abc transporter atp-binding protein
K3757_RS11980	COG0577	efflux transmembrane transporter activity
K3757_RS11980	COG1136	(ABC) transporter
K3757_RS12000	COG0783	Belongs to the Dps family
K3757_RS12005	COG0583	DNA-binding transcription factor activity
K3757_RS12020	COG0484	heat shock protein binding
K3757_RS12030	COG0662	Cupin 2, conserved barrel domain protein
K3757_RS12035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K3757_RS12055	COG0356	it plays a direct role in the translocation of protons across the membrane
K3757_RS12065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3757_RS12065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3757_RS12070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K3757_RS12075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K3757_RS12080	COG3243	poly(R)-hydroxyalkanoic acid synthase
K3757_RS12125	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K3757_RS12145	COG1172	Belongs to the binding-protein-dependent transport system permease family
K3757_RS12175	COG1175	transmembrane transport
K3757_RS12180	COG0395	ABC-type sugar transport system, permease component
K3757_RS12185	COG3842	ATPase activity
K3757_RS12190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3757_RS12225	COG1175	transmembrane transport
K3757_RS12255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K3757_RS12260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K3757_RS12265	COG1116	anion transmembrane transporter activity
K3757_RS12270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K3757_RS12275	COG2146	nitrite reductase [NAD(P)H] activity
K3757_RS12280	COG0243	molybdopterin cofactor binding
K3757_RS12285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3757_RS12290	COG1648	precorrin-2 dehydrogenase activity
K3757_RS12290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K3757_RS12305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3757_RS12310	COG1024	Enoyl-CoA hydratase
K3757_RS12325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3757_RS12335	COG0798	PFAM Bile acid sodium symporter
K3757_RS12350	COG1414	Transcriptional regulator
K3757_RS12355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3757_RS12365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3757_RS12375	COG0492	ferredoxin-NADP+ reductase activity
K3757_RS12380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3757_RS12385	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS12390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3757_RS12395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3757_RS12400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3757_RS12405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K3757_RS12410	COG0830	nickel cation binding
K3757_RS12415	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
K3757_RS12420	COG0804	urea catabolic process
K3757_RS12430	COG3755	Protein conserved in bacteria
K3757_RS12445	COG0831	urea catabolic process
K3757_RS12450	COG0829	nickel cation binding
K3757_RS12465	COG0628	permease
K3757_RS12470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3757_RS12485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3757_RS12520	COG0321	lipoyl(octanoyl) transferase activity
K3757_RS12525	COG2197	response regulator
K3757_RS12530	COG3852	Histidine kinase
K3757_RS12545	COG1610	YqeY-like protein
K3757_RS12550	COG0505	Belongs to the CarA family
K3757_RS12560	COG1802	Transcriptional regulator
K3757_RS12575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K3757_RS12585	COG0156	8-amino-7-oxononanoate synthase activity
K3757_RS12600	COG1053	succinate dehydrogenase
K3757_RS12605	COG1802	Transcriptional regulator
K3757_RS12610	COG3180	Ammonia monooxygenase
K3757_RS12620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K3757_RS12625	COG2828	Protein conserved in bacteria
K3757_RS12655	COG1522	sequence-specific DNA binding
K3757_RS12665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K3757_RS12680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K3757_RS12685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K3757_RS12690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K3757_RS12700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3757_RS12700	COG0574	Belongs to the PEP-utilizing enzyme family
K3757_RS12705	COG0751	glycine-tRNA ligase activity
K3757_RS12715	COG0752	glycyl-tRNA synthetase alpha subunit
K3757_RS12730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3757_RS12740	COG1469	GTP cyclohydrolase I activity
K3757_RS12750	COG0625	glutathione transferase activity
K3757_RS12755	COG2917	probably involved in intracellular septation
K3757_RS12765	COG0552	protein localization to endoplasmic reticulum
K3757_RS12770	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K3757_RS12775	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K3757_RS12785	COG1570	exodeoxyribonuclease VII activity
K3757_RS12790	COG0151	Belongs to the GarS family
K3757_RS12825	COG2010	Cytochrome c
K3757_RS12825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3757_RS12830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3757_RS12835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3757_RS12840	COG0330	HflC and HflK could
K3757_RS12855	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K3757_RS12870	COG1755	Isoprenylcysteine carboxyl methyltransferase
K3757_RS12875	COG0625	glutathione transferase activity
K3757_RS12880	COG1760	l-serine dehydratase
K3757_RS12910	COG1376	ErfK ybiS ycfS ynhG family protein
K3757_RS12920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K3757_RS12950	COG0504	CTP synthase activity
K3757_RS12955	COG0306	phosphate transporter
K3757_RS12965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K3757_RS12995	COG4215	(ABC) transporter
K3757_RS13000	COG0765	amino acid transport
K3757_RS13005	COG0174	glutamine synthetase
K3757_RS13010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3757_RS13010	COG0519	Catalyzes the synthesis of GMP from XMP
K3757_RS13015	COG0174	glutamine synthetase
K3757_RS13020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3757_RS13025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3757_RS13040	COG3243	poly(R)-hydroxyalkanoic acid synthase
K3757_RS13085	COG2814	Major facilitator Superfamily
K3757_RS13090	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K3757_RS13100	COG3220	belongs to the UPF0276 family
K3757_RS13115	COG1393	Belongs to the ArsC family
K3757_RS13120	COG1278	Cold shock
K3757_RS13135	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K3757_RS13165	COG0235	Class ii aldolase
K3757_RS13175	COG1846	Transcriptional regulator
K3757_RS13200	COG0534	Mate efflux family protein
K3757_RS13210	COG0596	Alpha beta hydrolase
K3757_RS13230	COG0662	Cupin 2, conserved barrel domain protein
K3757_RS13235	COG0187	DNA topoisomerase II activity
K3757_RS13255	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K3757_RS13265	COG1136	(ABC) transporter
K3757_RS13280	COG2133	pyrroloquinoline quinone binding
K3757_RS13285	COG0442	prolyl-tRNA aminoacylation
K3757_RS13290	COG2195	Cleaves the N-terminal amino acid of tripeptides
K3757_RS13295	COG0628	permease
K3757_RS13305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K3757_RS13310	COG0248	Ppx GppA phosphatase
K3757_RS13325	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K3757_RS13340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3757_RS13340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3757_RS13355	COG4770	biotin carboxylase activity
K3757_RS13390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3757_RS13400	COG3800	Transcriptional regulator
K3757_RS13400	COG1396	sequence-specific DNA binding
K3757_RS13405	COG1525	nuclease
K3757_RS13420	COG1012	belongs to the aldehyde dehydrogenase family
K3757_RS13430	COG3119	arylsulfatase activity
K3757_RS13435	COG1309	transcriptional regulator
K3757_RS13455	COG0217	transcriptional regulatory protein
K3757_RS13460	COG0490	domain, Protein
K3757_RS13460	COG0471	metal ion transport
K3757_RS13465	COG3273	potassium ion transport
K3757_RS13465	COG0471	metal ion transport
K3757_RS13475	COG1692	metallophosphoesterase
K3757_RS13480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K3757_RS13485	COG2239	Acts as a magnesium transporter
K3757_RS13490	COG0402	S-adenosylhomocysteine deaminase activity
K3757_RS13515	COG0583	DNA-binding transcription factor activity
K3757_RS13525	COG0670	Belongs to the BI1 family
K3757_RS13530	COG3813	Protein conserved in bacteria
K3757_RS13535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K3757_RS13560	COG0154	amidase activity
K3757_RS13565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3757_RS13570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K3757_RS13575	COG0590	tRNA wobble adenosine to inosine editing
K3757_RS13580	COG1187	pseudouridine synthase activity
K3757_RS13600	COG3853	Toxic anion resistance protein (TelA)
K3757_RS13630	COG1490	D-aminoacyl-tRNA deacylase activity
K3757_RS13660	COG0747	negative chemotaxis
K3757_RS13670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3757_RS13675	COG4172	Belongs to the ABC transporter superfamily
K3757_RS13695	COG0657	acetylesterase activity
K3757_RS13700	COG0318	PFAM AMP-dependent synthetase and ligase
K3757_RS13705	COG1652	LysM domain
K3757_RS13710	COG1132	(ABC) transporter
K3757_RS13735	COG5598	trimethylamine methyltransferase
K3757_RS13745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3757_RS13745	COG2010	Cytochrome c
K3757_RS13755	COG4221	oxidoreductase activity
K3757_RS13760	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K3757_RS13775	COG1320	monovalent cation:proton antiporter activity
K3757_RS13780	COG2212	antiporter activity
K3757_RS13785	COG1863	multisubunit Na H antiporter MnhE subunit
K3757_RS13790	COG0651	ATP synthesis coupled electron transport
K3757_RS13795	COG1006	Multisubunit Na H antiporter MnhC subunit
K3757_RS13800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K3757_RS13800	COG2111	Na H antiporter
K3757_RS13810	COG1012	belongs to the aldehyde dehydrogenase family
K3757_RS13855	COG0583	DNA-binding transcription factor activity
K3757_RS13875	COG0702	epimerase
K3757_RS13910	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3757_RS13915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3757_RS13990	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K3757_RS14000	COG0424	maF-like protein
K3757_RS14005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K3757_RS14010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K3757_RS14015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K3757_RS14025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K3757_RS14030	COG1703	isobutyryl-CoA mutase activity
K3757_RS14035	COG1643	Atp-dependent helicase
K3757_RS14040	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K3757_RS14045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K3757_RS14055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K3757_RS14075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3757_RS14095	COG2943	transferase activity, transferring hexosyl groups
K3757_RS14120	COG1573	uracil-dna glycosylase
K3757_RS14140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3757_RS14185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K3757_RS14190	COG1214	PFAM Peptidase M22, glycoprotease
K3757_RS14200	COG1744	ABC transporter substrate-binding protein PnrA-like
K3757_RS14205	COG3845	ABC transporter
K3757_RS14210	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3757_RS14215	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3757_RS14220	COG0730	response to heat
K3757_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS14235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K3757_RS14250	COG0604	alcohol dehydrogenase
K3757_RS14255	COG2937	Belongs to the GPAT DAPAT family
K3757_RS14260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3757_RS14260	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3757_RS14275	COG0813	purine-nucleoside phosphorylase activity
K3757_RS14330	COG0039	L-malate dehydrogenase activity
K3757_RS14350	COG2301	Belongs to the HpcH HpaI aldolase family
K3757_RS14365	COG2030	dehydratase
K3757_RS14370	COG0045	succinate-CoA ligase (ADP-forming) activity
K3757_RS14385	COG0567	Dehydrogenase, E1 component
K3757_RS14390	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3757_RS14420	COG2884	Cell division ATP-binding protein ftsE
K3757_RS14435	COG0019	diaminopimelate decarboxylase activity
K3757_RS14450	COG0165	Argininosuccinate lyase
K3757_RS14455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3757_RS14470	COG3119	arylsulfatase activity
K3757_RS14480	COG0800	Aldolase
K3757_RS14485	COG0129	dihydroxy-acid dehydratase activity
K3757_RS14490	COG2183	response to ionizing radiation
K3757_RS14515	COG3734	2-keto-3-deoxy-galactonokinase
K3757_RS14525	COG4221	oxidoreductase activity
K3757_RS14530	COG4774	siderophore transport
K3757_RS14535	COG3128	pkhd-type hydroxylase
K3757_RS14545	COG0848	biopolymer transport protein
K3757_RS14580	COG5002	protein histidine kinase activity
K3757_RS14590	COG5002	protein histidine kinase activity
K3757_RS14605	COG0745	RESPONSE REGULATOR receiver
K3757_RS14620	COG1396	sequence-specific DNA binding
K3757_RS14625	COG2197	response regulator
K3757_RS14630	COG3916	Acyl-homoserine-lactone synthase
K3757_RS14635	COG0745	RESPONSE REGULATOR receiver
K3757_RS14640	COG2204	response regulator
K3757_RS14650	COG2864	formate dehydrogenase
K3757_RS14655	COG0437	4 iron, 4 sulfur cluster binding
K3757_RS14660	COG0243	molybdopterin cofactor binding
K3757_RS14660	COG3383	formate dehydrogenase (NAD+) activity
K3757_RS14695	COG0489	protein tyrosine kinase activity
K3757_RS14725	COG3852	Histidine kinase
K3757_RS14730	COG0697	spore germination
K3757_RS14735	COG1309	transcriptional regulator
K3757_RS14745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3757_RS14765	COG0318	PFAM AMP-dependent synthetase and ligase
K3757_RS14780	COG1473	amidohydrolase
K3757_RS14785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3757_RS14790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K3757_RS14795	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K3757_RS14800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3757_RS14810	COG0765	amino acid transport
K3757_RS14815	COG0765	amino acid transport
K3757_RS14820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3757_RS14825	COG0583	DNA-binding transcription factor activity
K3757_RS14830	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K3757_RS14860	COG5002	protein histidine kinase activity
K3757_RS14865	COG1349	DNA-binding transcription factor activity
K3757_RS14875	COG3842	ATPase activity
K3757_RS14880	COG3842	ATPase activity
K3757_RS14890	COG0395	ABC-type sugar transport system, permease component
K3757_RS14905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K3757_RS14910	COG1454	alcohol dehydrogenase
K3757_RS14935	COG2226	methyltransferase
K3757_RS14965	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K3757_RS14980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K3757_RS14995	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K3757_RS15010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K3757_RS15020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K3757_RS15030	COG0124	histidyl-tRNA synthetase
K3757_RS15035	COG2900	Belongs to the SlyX family
K3757_RS15055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K3757_RS15065	COG3845	ABC transporter
K3757_RS15070	COG4603	Belongs to the binding-protein-dependent transport system permease family
K3757_RS15075	COG1079	Belongs to the binding-protein-dependent transport system permease family
K3757_RS15090	COG0189	ligase activity
K3757_RS15090	COG4067	protein conserved in archaea
K3757_RS15095	COG0189	ligase activity
K3757_RS15100	COG3608	succinylglutamate desuccinylase aspartoacylase
K3757_RS15110	COG0667	Aldo Keto reductase
K3757_RS15140	COG0277	FAD linked oxidase domain protein
K3757_RS15230	COG2814	Major facilitator Superfamily
K3757_RS15245	COG0656	L-ascorbic acid biosynthetic process
K3757_RS15315	COG0489	protein tyrosine kinase activity
K3757_RS15325	COG3409	Peptidoglycan-binding domain 1 protein
K3757_RS15325	COG3267	Type II secretory pathway component ExeA
K3757_RS15330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K3757_RS15355	COG1216	Glycosyl transferase, family 2
K3757_RS15365	COG1215	transferase activity, transferring glycosyl groups
K3757_RS15370	COG1215	transferase activity, transferring glycosyl groups
K3757_RS15375	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K3757_RS15380	COG0297	glycogen (starch) synthase activity
K3757_RS15395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K3757_RS15435	COG1796	DNA polymerase
K3757_RS15435	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K3757_RS15450	COG1177	transmembrane transport
K3757_RS15455	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3757_RS15470	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K3757_RS15475	COG1522	sequence-specific DNA binding
K3757_RS15485	COG1024	Enoyl-CoA hydratase
K3757_RS15500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3757_RS15515	COG0643	Histidine kinase
K3757_RS15515	COG0784	Response regulator, receiver
K3757_RS15515	COG2198	Histidine kinase
K3757_RS15520	COG4251	negative regulation of phosphorylation
K3757_RS15530	COG1162	GTPase activity
K3757_RS15550	COG0348	domain, Protein
K3757_RS15555	COG2010	Cytochrome c
K3757_RS15575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3757_RS15580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3757_RS15590	COG1215	transferase activity, transferring glycosyl groups
K3757_RS15600	COG2205	protein histidine kinase activity
K3757_RS15630	COG1126	abc transporter atp-binding protein
K3757_RS15635	COG0765	amino acid transport
K3757_RS15640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K3757_RS15650	COG0438	transferase activity, transferring glycosyl groups
K3757_RS15655	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
K3757_RS15665	COG1840	ABC-type Fe3 transport system, periplasmic component
K3757_RS15670	COG0546	phosphoglycolate phosphatase activity
K3757_RS15675	COG1473	amidohydrolase
K3757_RS15685	COG0745	RESPONSE REGULATOR receiver
K3757_RS15755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3757_RS15770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K3757_RS15790	COG0318	PFAM AMP-dependent synthetase and ligase
K3757_RS15795	COG1024	Enoyl-CoA hydratase
K3757_RS15805	COG1960	acyl-CoA dehydrogenase activity
K3757_RS15810	COG1960	acyl-CoA dehydrogenase activity
K3757_RS15855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K3757_RS15875	COG0556	nucleotide-excision repair
K3757_RS15905	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K3757_RS15925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K3757_RS15930	COG1115	amino acid carrier protein
K3757_RS15940	COG0488	(ABC) transporter
K3757_RS15950	COG1278	Cold shock
K3757_RS15955	COG1376	ErfK ybiS ycfS ynhG family protein
K3757_RS15965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K3757_RS15970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K3757_RS15975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K3757_RS15995	COG1309	transcriptional regulator
K3757_RS16010	COG5507	3-demethylubiquinone-9 3-methyltransferase
K3757_RS16015	COG0493	'glutamate synthase
K3757_RS16025	COG4181	ATPase activity
K3757_RS16035	COG0483	inositol monophosphate 1-phosphatase activity
K3757_RS16040	COG0509	glycine decarboxylation via glycine cleavage system
K3757_RS16050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3757_RS16090	COG3046	protein related to deoxyribodipyrimidine photolyase
K3757_RS16095	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS16100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3757_RS16115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3757_RS16120	COG0252	asparaginase activity
K3757_RS16135	COG0583	DNA-binding transcription factor activity
K3757_RS16160	COG0768	penicillin binding
K3757_RS16165	COG0772	Belongs to the SEDS family
K3757_RS16175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K3757_RS16180	COG0339	signal peptide processing
K3757_RS16185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K3757_RS16190	COG0756	dUTP diphosphatase activity
K3757_RS16195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K3757_RS16225	COG0606	chelatase, subunit chli
K3757_RS16235	COG0189	ligase activity
K3757_RS16240	COG0792	nuclease activity
K3757_RS16245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K3757_RS16255	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K3757_RS16275	COG0180	Tryptophanyl-tRNA synthetase
K3757_RS16280	COG2514	catechol 2,3-dioxygenase activity
K3757_RS16290	COG0778	Nitroreductase
K3757_RS16305	COG0346	lactoylglutathione lyase activity
K3757_RS16310	COG0745	RESPONSE REGULATOR receiver
K3757_RS16325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K3757_RS16340	COG1127	ABC transporter
K3757_RS16345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K3757_RS16355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3757_RS16360	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3757_RS16375	COG0601	transmembrane transport
K3757_RS16380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3757_RS16385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K3757_RS16390	COG0668	transmembrane transport
K3757_RS16395	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K3757_RS16410	COG0438	transferase activity, transferring glycosyl groups
K3757_RS16415	COG0588	phosphoglycerate mutase activity
K3757_RS16430	COG3246	L-lysine catabolic process to acetate
K3757_RS16440	COG2824	Alkylphosphonate utilization operon protein PhnA
K3757_RS16455	COG0481	GTPase activity
K3757_RS16475	COG5328	Belongs to the UPF0262 family
K3757_RS16480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K3757_RS16490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K3757_RS16515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K3757_RS16525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K3757_RS16540	COG2951	lytic endotransglycosylase activity
K3757_RS16555	COG1573	uracil-dna glycosylase
K3757_RS16580	COG0028	Belongs to the TPP enzyme family
K3757_RS16600	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K3757_RS16605	COG0709	Synthesizes selenophosphate from selenide and ATP
K3757_RS16630	COG1921	L-seryl-tRNASec selenium transferase activity
K3757_RS16660	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K3757_RS16665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3757_RS16685	COG0284	orotidine-5'-phosphate decarboxylase activity
K3757_RS16695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K3757_RS16710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K3757_RS16720	COG0625	glutathione transferase activity
K3757_RS16725	COG1178	ABC-type Fe3 transport system permease component
K3757_RS16730	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K3757_RS16755	COG0559	Belongs to the binding-protein-dependent transport system permease family
K3757_RS16770	COG3852	Histidine kinase
K3757_RS16785	COG3383	formate dehydrogenase (NAD+) activity
K3757_RS16825	COG1595	DNA-templated transcription, initiation
K3757_RS16830	COG3806	Anti-sigma factor
K3757_RS16845	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K3757_RS16860	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
K3757_RS16865	COG3257	ureidoglycine aminohydrolase activity
K3757_RS16885	COG2351	hydroxyisourate hydrolase activity
K3757_RS16895	COG1012	belongs to the aldehyde dehydrogenase family
K3757_RS16900	COG0612	Peptidase, M16
K3757_RS16905	COG0612	Peptidase, M16
K3757_RS16915	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K3757_RS16920	COG0138	bifunctional purine biosynthesis protein purh
K3757_RS16935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3757_RS16935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K3757_RS16950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K3757_RS16955	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K3757_RS16965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K3757_RS16980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K3757_RS16990	COG0154	amidase activity
K3757_RS17010	COG1185	polyribonucleotide nucleotidyltransferase activity
K3757_RS17015	COG1376	ErfK ybiS ycfS ynhG family protein
K3757_RS17025	COG0450	alkyl hydroperoxide reductase
K3757_RS17035	COG0564	pseudouridine synthase activity
K3757_RS17055	COG2040	homocysteine
K3757_RS17090	COG1366	Belongs to the anti-sigma-factor antagonist family
K3757_RS17100	COG0405	Gamma-glutamyltransferase
K3757_RS17125	COG1674	ftsk spoiiie
K3757_RS17135	COG0154	amidase activity
K3757_RS17140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K3757_RS17145	COG2835	tetraacyldisaccharide 4'-kinase activity
K3757_RS17150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K3757_RS17160	COG0708	Exodeoxyribonuclease III
K3757_RS17165	COG0745	RESPONSE REGULATOR receiver
K3757_RS17180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K3757_RS17195	COG0495	leucyl-tRNA aminoacylation
K3757_RS17215	COG2081	HI0933 family
K3757_RS17220	COG1196	nuclear chromosome segregation
K3757_RS17220	COG3264	Mechanosensitive ion channel
K3757_RS17245	COG0312	modulator of DNA gyrase
K3757_RS17260	COG1519	Transferase
K3757_RS17265	COG1663	tetraacyldisaccharide 4'-kinase activity
K3757_RS17275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K3757_RS17305	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K3757_RS17340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K3757_RS17365	COG0288	reversible hydration of carbon dioxide
K3757_RS17375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3757_RS17380	COG0791	NLP P60 protein
K3757_RS17390	COG2050	protein possibly involved in aromatic compounds catabolism
K3757_RS17415	COG0679	Auxin Efflux Carrier
K3757_RS17420	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K3757_RS17425	COG1671	Belongs to the UPF0178 family
K3757_RS17435	COG2423	ornithine cyclodeaminase activity
K3757_RS17450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K3757_RS17460	COG0285	dihydrofolate synthase activity
K3757_RS17465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K3757_RS17480	COG0129	dihydroxy-acid dehydratase activity
K3757_RS17500	COG0793	Belongs to the peptidase S41A family
K3757_RS17510	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3757_RS17520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3757_RS17520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3757_RS17530	COG3622	Belongs to the hyi family
K3757_RS17540	COG0714	Associated with various cellular activities
K3757_RS17570	COG4953	penicillin-binding protein 1C
K3757_RS17575	COG2373	Large extracellular alpha-helical protein
K3757_RS17580	COG5002	protein histidine kinase activity
K3757_RS17580	COG2205	protein histidine kinase activity
K3757_RS17580	COG0784	Response regulator, receiver
K3757_RS17585	COG3022	response to hydroperoxide
K3757_RS17590	COG0514	ATP-dependent DNA helicase (RecQ)
K3757_RS17615	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K3757_RS17625	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K3757_RS17645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K3757_RS17645	COG1648	precorrin-2 dehydrogenase activity
K3757_RS17650	COG1797	cobyrinic acid a,c-diamide synthase activity
K3757_RS17655	COG2875	Belongs to the precorrin methyltransferase family
K3757_RS17670	COG2099	Precorrin-6x reductase
K3757_RS17725	COG0697	spore germination
K3757_RS17735	COG0803	Belongs to the bacterial solute-binding protein 9 family
K3757_RS17740	COG1121	(ABC) transporter
K3757_RS17745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K3757_RS17750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K3757_RS17760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K3757_RS17765	COG1335	isochorismatase
K3757_RS17770	COG1054	Belongs to the UPF0176 family
K3757_RS17775	COG2271	Major facilitator Superfamily
K3757_RS17780	COG1360	Flagellar Motor Protein
K3757_RS17800	COG1706	bacterial-type flagellum-dependent cell motility
K3757_RS17810	COG1338	Plays a role in the flagellum-specific transport system
K3757_RS17815	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3757_RS17825	COG1766	The M ring may be actively involved in energy transduction
K3757_RS17855	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K3757_RS17860	COG1684	flagellar biosynthetic protein fliR
K3757_RS17865	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K3757_RS17880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K3757_RS17885	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
K3757_RS17890	COG4786	Flagellar basal body rod
K3757_RS17895	COG4786	Flagellar basal body rod
K3757_RS17905	COG1677	Flagellar hook-basal body complex protein FliE
K3757_RS17910	COG1558	bacterial-type flagellum-dependent cell motility
K3757_RS17930	COG5443	negative regulation of bacterial-type flagellum assembly
K3757_RS17940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K3757_RS17965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3757_RS17970	COG1177	transmembrane transport
K3757_RS17975	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3757_RS17980	COG3842	ATPase activity
K3757_RS17995	COG3842	ATPase activity
K3757_RS18005	COG1176	ABC-type spermidine putrescine transport system, permease component I
K3757_RS18025	COG0557	exoribonuclease II activity
K3757_RS18040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3757_RS18065	COG2171	N-acyltransferase activity
K3757_RS18080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K3757_RS18095	COG3830	Belongs to the UPF0237 family
K3757_RS18095	COG0560	Phosphoserine phosphatase
K3757_RS18105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K3757_RS18110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K3757_RS18120	COG1063	alcohol dehydrogenase
K3757_RS18125	COG0156	8-amino-7-oxononanoate synthase activity
K3757_RS18130	COG1396	sequence-specific DNA binding
K3757_RS18135	COG0183	Belongs to the thiolase family
K3757_RS18145	COG2226	methyltransferase
K3757_RS18150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K3757_RS18155	COG1024	Enoyl-CoA hydratase
K3757_RS18165	COG0268	Binds directly to 16S ribosomal RNA
K3757_RS18245	COG3485	protocatechuate 3,4-dioxygenase
K3757_RS18250	COG3485	protocatechuate 3,4-dioxygenase
K3757_RS18260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K3757_RS18270	COG0583	DNA-binding transcription factor activity
K3757_RS18290	COG0446	pyridine nucleotide-disulphide oxidoreductase
K3757_RS18290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3757_RS18295	COG4311	Sarcosine oxidase, delta subunit
K3757_RS18300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3757_RS18305	COG2304	oxidoreductase activity
K3757_RS18310	COG0348	domain, Protein
K3757_RS18310	COG3901	Regulator of nitric oxide reductase transcription
K3757_RS18365	COG1131	(ABC) transporter
K3757_RS18395	COG2205	protein histidine kinase activity
K3757_RS18395	COG2198	Histidine kinase
K3757_RS18395	COG0784	Response regulator, receiver
K3757_RS18400	COG0535	radical SAM domain protein
K3757_RS18410	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
K3757_RS18415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K3757_RS18425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3757_RS18440	COG0436	Aminotransferase
K3757_RS18445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3757_RS18465	COG3386	PFAM SMP-30 Gluconolaconase
K3757_RS18480	COG1192	Involved in chromosome partitioning
K3757_RS18485	COG1475	DNA binding
K3757_RS18505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3757_RS18510	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3757_RS18515	COG1028	Short-chain dehydrogenase reductase Sdr
K3757_RS18610	COG0631	protein serine/threonine phosphatase activity
K3757_RS18690	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K3757_RS18710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K3757_RS18730	COG0484	heat shock protein binding
K3757_RS18750	COG0463	Glycosyl transferase, family 2
K3757_RS18760	COG0438	transferase activity, transferring glycosyl groups
K3757_RS18785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K3757_RS18815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K3757_RS18815	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K3757_RS18820	COG2942	2-epimerase
K3757_RS18830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3757_RS18855	COG1192	Involved in chromosome partitioning
K3757_RS18865	COG1215	transferase activity, transferring glycosyl groups
K3757_RS18895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3757_RS18920	COG0463	Glycosyl transferase, family 2
K3757_RS18930	COG3754	Rhamnan synthesis protein F
K3757_RS18945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K3757_RS18950	COG1091	dTDP-4-dehydrorhamnose reductase activity
K3757_RS18955	COG1088	dTDP-glucose 4,6-dehydratase activity
K3757_RS18960	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K3757_RS19010	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity