locus-tag	class	description
C1J02_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1J02_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1J02_RS00030	COG3008	intermembrane lipid transfer
C1J02_RS00035	COG2995	paraquat-inducible protein a
C1J02_RS00045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J02_RS00075	COG2358	TRAP transporter, solute receptor (TAXI family
C1J02_RS00080	COG0069	glutamate synthase activity
C1J02_RS00085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1J02_RS00090	COG1396	sequence-specific DNA binding
C1J02_RS00110	COG0784	Response regulator, receiver
C1J02_RS00135	COG1295	ribonuclease BN
C1J02_RS00140	COG2116	formate transmembrane transporter activity
C1J02_RS00150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J02_RS00155	COG0443	Heat shock 70 kDa protein
C1J02_RS00180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J02_RS00190	COG2267	carboxylic ester hydrolase activity
C1J02_RS00200	COG0662	Cupin 2, conserved barrel domain protein
C1J02_RS00205	COG3191	aminopeptidase activity
C1J02_RS00235	COG2217	Heavy metal translocating P-type atpase
C1J02_RS00240	COG1609	Transcriptional regulator
C1J02_RS00260	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS00265	COG0318	PFAM AMP-dependent synthetase and ligase
C1J02_RS00275	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C1J02_RS00275	COG0662	Cupin 2, conserved barrel domain protein
C1J02_RS00280	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C1J02_RS00285	COG0058	SHG alpha-glucan phosphorylase activity
C1J02_RS00290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1J02_RS00295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1J02_RS00300	COG0297	glycogen (starch) synthase activity
C1J02_RS00315	COG0033	Phosphoglucomutase
C1J02_RS00320	COG3119	arylsulfatase activity
C1J02_RS00330	COG1960	acyl-CoA dehydrogenase activity
C1J02_RS00370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1J02_RS00375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1J02_RS00405	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1J02_RS00410	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1J02_RS00420	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C1J02_RS00425	COG1999	signal sequence binding
C1J02_RS00440	COG0802	atpase or kinase
C1J02_RS00445	COG3178	'Phosphotransferase
C1J02_RS00450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1J02_RS00460	COG1074	ATP-dependent DNA helicase activity
C1J02_RS00475	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C1J02_RS00480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1J02_RS00510	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C1J02_RS00520	COG0237	dephospho-CoA kinase activity
C1J02_RS00530	COG0424	maF-like protein
C1J02_RS00535	COG1981	membrane
C1J02_RS00540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1J02_RS00545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1J02_RS00550	COG0445	tRNA wobble uridine modification
C1J02_RS00555	COG0357	Ribosomal RNA small subunit methyltransferase G
C1J02_RS00570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1J02_RS00575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1J02_RS00580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1J02_RS00585	COG1420	regulation of RNA biosynthetic process
C1J02_RS00590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1J02_RS00595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1J02_RS00605	COG0281	malic enzyme
C1J02_RS00605	COG0280	phosphate acetyltransferase
C1J02_RS00610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1J02_RS00615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1J02_RS00625	COG0137	argininosuccinate synthase activity
C1J02_RS00630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1J02_RS00635	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS00645	COG0745	RESPONSE REGULATOR receiver
C1J02_RS00650	COG0494	nUDIX hydrolase
C1J02_RS00660	COG0494	nUDIX hydrolase
C1J02_RS00665	COG0617	tRNA 3'-terminal CCA addition
C1J02_RS00670	COG1132	(ABC) transporter
C1J02_RS00675	COG1132	(ABC) transporter
C1J02_RS00685	COG3034	peptidoglycan biosynthetic process
C1J02_RS00735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1J02_RS00745	COG0747	negative chemotaxis
C1J02_RS00750	COG0779	Required for maturation of 30S ribosomal subunits
C1J02_RS00765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1J02_RS00770	COG0494	nUDIX hydrolase
C1J02_RS00775	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1J02_RS00780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1J02_RS00785	COG0653	protein targeting
C1J02_RS00800	COG2003	Belongs to the UPF0758 family
C1J02_RS00810	COG0484	heat shock protein binding
C1J02_RS00815	COG0443	Heat shock 70 kDa protein
C1J02_RS00830	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1J02_RS00835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1J02_RS00850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1J02_RS00875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1J02_RS00880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1J02_RS00885	COG1137	ATPase activity
C1J02_RS00900	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1J02_RS00900	COG0517	IMP dehydrogenase activity
C1J02_RS00905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1J02_RS00910	COG3327	negative regulation of DNA-templated transcription, initiation
C1J02_RS00915	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS00915	COG2030	dehydratase
C1J02_RS00920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1J02_RS00925	COG2151	metal-sulfur cluster biosynthetic enzyme
C1J02_RS00930	COG3396	Phenylacetate-CoA oxygenase
C1J02_RS00935	COG3460	Phenylacetate-CoA oxygenase
C1J02_RS00940	COG3396	Phenylacetate-CoA oxygenase
C1J02_RS00945	COG0183	Belongs to the thiolase family
C1J02_RS00960	COG1215	transferase activity, transferring glycosyl groups
C1J02_RS01000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1J02_RS01005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1J02_RS01035	COG0747	negative chemotaxis
C1J02_RS01090	COG4227	nucleotidyltransferase activity
C1J02_RS01125	COG0582	viral genome integration into host DNA
C1J02_RS01175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1J02_RS01185	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1J02_RS01195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1J02_RS01200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1J02_RS01225	COG3920	Histidine kinase
C1J02_RS01235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1J02_RS01240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C1J02_RS01300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1J02_RS01305	COG0142	geranyltranstransferase activity
C1J02_RS01310	COG1722	exodeoxyribonuclease VII activity
C1J02_RS01315	COG0745	RESPONSE REGULATOR receiver
C1J02_RS01320	COG1846	Transcriptional regulator
C1J02_RS01325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1J02_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS01350	COG1309	transcriptional regulator
C1J02_RS01355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1J02_RS01360	COG4143	(ABC) transporter
C1J02_RS01365	COG1178	ABC-type Fe3 transport system permease component
C1J02_RS01370	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1J02_RS01380	COG2808	Putative FMN-binding domain
C1J02_RS01385	COG0625	glutathione transferase activity
C1J02_RS01410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1J02_RS01415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1J02_RS01470	COG0028	Belongs to the TPP enzyme family
C1J02_RS01475	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS01495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1J02_RS01500	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C1J02_RS01500	COG1082	Xylose isomerase domain protein TIM barrel
C1J02_RS01505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J02_RS01515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS01530	COG0583	DNA-binding transcription factor activity
C1J02_RS01535	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J02_RS01540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J02_RS01545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS01550	COG3119	arylsulfatase activity
C1J02_RS01560	COG2514	catechol 2,3-dioxygenase activity
C1J02_RS01570	COG0778	Nitroreductase
C1J02_RS01585	COG0346	lactoylglutathione lyase activity
C1J02_RS01590	COG0745	RESPONSE REGULATOR receiver
C1J02_RS01610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1J02_RS01635	COG2723	6-phospho-beta-galactosidase activity
C1J02_RS01640	COG1609	Transcriptional regulator
C1J02_RS01645	COG1653	transport
C1J02_RS01650	COG1175	transmembrane transport
C1J02_RS01655	COG0395	ABC-type sugar transport system, permease component
C1J02_RS01660	COG0366	Alpha amylase catalytic
C1J02_RS01665	COG3842	ATPase activity
C1J02_RS01695	COG2084	Dehydrogenase
C1J02_RS01700	COG1396	sequence-specific DNA binding
C1J02_RS01715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J02_RS01725	COG0557	exoribonuclease II activity
C1J02_RS01735	COG2378	regulation of single-species biofilm formation
C1J02_RS01740	COG2951	lytic endotransglycosylase activity
C1J02_RS01750	COG1802	Transcriptional regulator
C1J02_RS01760	COG3842	ATPase activity
C1J02_RS01765	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J02_RS01770	COG1177	transmembrane transport
C1J02_RS01775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J02_RS01780	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C1J02_RS01805	COG2271	Major facilitator Superfamily
C1J02_RS01810	COG1054	Belongs to the UPF0176 family
C1J02_RS01815	COG1335	isochorismatase
C1J02_RS01825	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C1J02_RS01870	COG4941	Belongs to the sigma-70 factor family
C1J02_RS01940	COG2099	Precorrin-6x reductase
C1J02_RS01960	COG2875	Belongs to the precorrin methyltransferase family
C1J02_RS01965	COG1797	cobyrinic acid a,c-diamide synthase activity
C1J02_RS01990	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1J02_RS02000	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C1J02_RS02020	COG0514	ATP-dependent DNA helicase (RecQ)
C1J02_RS02025	COG3022	response to hydroperoxide
C1J02_RS02030	COG2205	protein histidine kinase activity
C1J02_RS02030	COG0784	Response regulator, receiver
C1J02_RS02030	COG5002	protein histidine kinase activity
C1J02_RS02035	COG2373	Large extracellular alpha-helical protein
C1J02_RS02040	COG4953	penicillin-binding protein 1C
C1J02_RS02070	COG0714	Associated with various cellular activities
C1J02_RS02080	COG3622	Belongs to the hyi family
C1J02_RS02095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1J02_RS02095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1J02_RS02110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1J02_RS02120	COG0793	Belongs to the peptidase S41A family
C1J02_RS02140	COG0129	dihydroxy-acid dehydratase activity
C1J02_RS02145	COG2274	protein secretion by the type I secretion system
C1J02_RS02155	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1J02_RS02160	COG0285	dihydrofolate synthase activity
C1J02_RS02170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1J02_RS02175	COG2423	ornithine cyclodeaminase activity
C1J02_RS02185	COG1671	Belongs to the UPF0178 family
C1J02_RS02190	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C1J02_RS02195	COG0679	Auxin Efflux Carrier
C1J02_RS02220	COG2050	protein possibly involved in aromatic compounds catabolism
C1J02_RS02230	COG0791	NLP P60 protein
C1J02_RS02235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1J02_RS02245	COG0288	reversible hydration of carbon dioxide
C1J02_RS02255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1J02_RS02285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1J02_RS02320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J02_RS02325	COG1663	tetraacyldisaccharide 4'-kinase activity
C1J02_RS02330	COG1519	Transferase
C1J02_RS02345	COG0312	modulator of DNA gyrase
C1J02_RS02370	COG1196	nuclear chromosome segregation
C1J02_RS02370	COG3264	Mechanosensitive ion channel
C1J02_RS02375	COG2081	HI0933 family
C1J02_RS02395	COG0495	leucyl-tRNA aminoacylation
C1J02_RS02410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1J02_RS02425	COG0745	RESPONSE REGULATOR receiver
C1J02_RS02445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1J02_RS02450	COG2835	tetraacyldisaccharide 4'-kinase activity
C1J02_RS02455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1J02_RS02465	COG0436	Aminotransferase
C1J02_RS02470	COG1674	ftsk spoiiie
C1J02_RS02490	COG0405	Gamma-glutamyltransferase
C1J02_RS02500	COG1366	Belongs to the anti-sigma-factor antagonist family
C1J02_RS02520	COG1280	lysine exporter protein (LysE YggA)
C1J02_RS02550	COG0564	pseudouridine synthase activity
C1J02_RS02570	COG0450	alkyl hydroperoxide reductase
C1J02_RS02590	COG1185	polyribonucleotide nucleotidyltransferase activity
C1J02_RS02595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1J02_RS02600	COG0395	ABC-type sugar transport system, permease component
C1J02_RS02605	COG1175	transmembrane transport
C1J02_RS02615	COG3842	ATPase activity
C1J02_RS02620	COG1349	DNA-binding transcription factor activity
C1J02_RS02630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1J02_RS02645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1J02_RS02650	COG3698	Phosphodiester glycosidase
C1J02_RS02655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1J02_RS02660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1J02_RS02690	COG0138	bifunctional purine biosynthesis protein purh
C1J02_RS02705	COG0612	Peptidase, M16
C1J02_RS02710	COG0612	Peptidase, M16
C1J02_RS02715	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS02730	COG0745	RESPONSE REGULATOR receiver
C1J02_RS02735	COG4191	Histidine kinase
C1J02_RS02735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1J02_RS02740	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1J02_RS02745	COG1121	(ABC) transporter
C1J02_RS02750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1J02_RS02755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1J02_RS02760	COG2351	hydroxyisourate hydrolase activity
C1J02_RS02770	COG1652	LysM domain
C1J02_RS02775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1J02_RS02785	COG3806	Anti-sigma factor
C1J02_RS02790	COG1595	DNA-templated transcription, initiation
C1J02_RS02835	COG3383	formate dehydrogenase (NAD+) activity
C1J02_RS02850	COG4191	Histidine kinase
C1J02_RS02865	COG0559	Belongs to the binding-protein-dependent transport system permease family
C1J02_RS02895	COG1178	ABC-type Fe3 transport system permease component
C1J02_RS02905	COG1840	ABC-type Fe3 transport system, periplasmic component
C1J02_RS02910	COG0625	glutathione transferase activity
C1J02_RS02930	COG1522	sequence-specific DNA binding
C1J02_RS02935	COG3119	arylsulfatase activity
C1J02_RS02950	COG1940	carbohydrate kinase activity
C1J02_RS02955	COG3119	arylsulfatase activity
C1J02_RS02960	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS02970	COG2188	Transcriptional regulator
C1J02_RS02975	COG4948	Mandelate Racemase Muconate Lactonizing
C1J02_RS02980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1J02_RS02990	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1J02_RS02995	COG0306	phosphate transporter
C1J02_RS03020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1J02_RS03030	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1J02_RS03035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1J02_RS03060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1J02_RS03065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1J02_RS03070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1J02_RS03085	COG1067	ATP-dependent peptidase activity
C1J02_RS03110	COG1609	Transcriptional regulator
C1J02_RS03115	COG0673	inositol 2-dehydrogenase activity
C1J02_RS03125	COG0673	inositol 2-dehydrogenase activity
C1J02_RS03130	COG3962	Belongs to the TPP enzyme family
C1J02_RS03140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1J02_RS03155	COG0673	inositol 2-dehydrogenase activity
C1J02_RS03180	COG3263	regulation of cellular component size
C1J02_RS03190	COG0745	RESPONSE REGULATOR receiver
C1J02_RS03195	COG2205	protein histidine kinase activity
C1J02_RS03200	COG1271	oxidase subunit
C1J02_RS03205	COG1294	oxidase, subunit
C1J02_RS03215	COG0604	alcohol dehydrogenase
C1J02_RS03215	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS03215	COG3321	synthase
C1J02_RS03220	COG0697	spore germination
C1J02_RS03230	COG1131	(ABC) transporter
C1J02_RS03235	COG0842	Transport permease protein
C1J02_RS03255	COG0322	excinuclease ABC activity
C1J02_RS03260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1J02_RS03270	COG0314	molybdopterin synthase activity
C1J02_RS03275	COG0589	response to stress
C1J02_RS03285	COG2885	chlorophyll binding
C1J02_RS03295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1J02_RS03325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1J02_RS03330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1J02_RS03345	COG0540	Belongs to the ATCase OTCase family
C1J02_RS03350	COG1573	uracil-dna glycosylase
C1J02_RS03355	COG1280	lysine exporter protein (LysE YggA)
C1J02_RS03360	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1J02_RS03380	COG1678	Uncharacterized ACR, COG1678
C1J02_RS03385	COG0009	L-threonylcarbamoyladenylate synthase
C1J02_RS03390	COG1960	acyl-CoA dehydrogenase activity
C1J02_RS03425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1J02_RS03430	COG0746	molybdenum cofactor guanylyltransferase activity
C1J02_RS03435	COG1763	Mo-molybdopterin cofactor biosynthetic process
C1J02_RS03440	COG0303	'Molybdopterin
C1J02_RS03450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1J02_RS03460	COG0789	Transcriptional regulator
C1J02_RS03480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1J02_RS03485	COG0142	geranyltranstransferase activity
C1J02_RS03495	COG2890	protein-(glutamine-N5) methyltransferase activity
C1J02_RS03510	COG0583	DNA-binding transcription factor activity
C1J02_RS03520	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS03535	COG2818	Glycosylase
C1J02_RS03540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1J02_RS03550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1J02_RS03555	COG0287	Prephenate dehydrogenase
C1J02_RS03570	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C1J02_RS03595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1J02_RS03610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1J02_RS03615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1J02_RS03620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1J02_RS03625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1J02_RS03630	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1J02_RS03650	COG2226	methyltransferase
C1J02_RS03650	COG1073	alpha beta
C1J02_RS03660	COG2983	Belongs to the UPF0260 family
C1J02_RS03665	COG0196	riboflavin kinase activity
C1J02_RS03670	COG2030	dehydratase
C1J02_RS03680	COG1227	inorganic diphosphatase activity
C1J02_RS03695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1J02_RS03700	COG0459	protein refolding
C1J02_RS03705	COG2197	response regulator
C1J02_RS03710	COG4251	negative regulation of phosphorylation
C1J02_RS03720	COG2205	protein histidine kinase activity
C1J02_RS03745	COG3454	Phosphonate metabolism
C1J02_RS03750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1J02_RS03765	COG0071	Belongs to the small heat shock protein (HSP20) family
C1J02_RS03785	COG0529	Catalyzes the synthesis of activated sulfate
C1J02_RS03785	COG2046	Belongs to the sulfate adenylyltransferase family
C1J02_RS03790	COG0492	ferredoxin-NADP+ reductase activity
C1J02_RS03800	COG1522	sequence-specific DNA binding
C1J02_RS03810	COG1496	oxidoreductase activity
C1J02_RS03820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1J02_RS03840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1J02_RS03845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1J02_RS03850	COG1435	thymidine kinase activity
C1J02_RS03860	COG0431	NADPH-dependent FMN reductase
C1J02_RS03885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1J02_RS03890	COG0596	Alpha beta hydrolase
C1J02_RS03925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1J02_RS03930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1J02_RS03935	COG3237	CsbD-like
C1J02_RS03950	COG0281	malic enzyme
C1J02_RS03950	COG0280	phosphate acetyltransferase
C1J02_RS03960	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C1J02_RS03965	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C1J02_RS03970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1J02_RS03985	COG0318	PFAM AMP-dependent synthetase and ligase
C1J02_RS04005	COG1024	Enoyl-CoA hydratase
C1J02_RS04005	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J02_RS04015	COG0183	Belongs to the thiolase family
C1J02_RS04020	COG0625	glutathione transferase activity
C1J02_RS04025	COG1960	acyl-CoA dehydrogenase activity
C1J02_RS04035	COG1960	acyl-CoA dehydrogenase activity
C1J02_RS04040	COG0789	Transcriptional regulator
C1J02_RS04060	COG0534	Mate efflux family protein
C1J02_RS04065	COG1393	Belongs to the ArsC family
C1J02_RS04070	COG0167	dihydroorotate dehydrogenase activity
C1J02_RS04080	COG0737	Belongs to the 5'-nucleotidase family
C1J02_RS04090	COG2135	peptidase activity
C1J02_RS04100	COG0583	DNA-binding transcription factor activity
C1J02_RS04105	COG1960	acyl-CoA dehydrogenase activity
C1J02_RS04110	COG0022	dehydrogenase e1 component
C1J02_RS04115	COG3842	ATPase activity
C1J02_RS04125	COG1175	transmembrane transport
C1J02_RS04130	COG0395	ABC-type sugar transport system, permease component
C1J02_RS04140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1J02_RS04150	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS04185	COG4948	Mandelate Racemase Muconate Lactonizing
C1J02_RS04195	COG2175	clavaminate synthase activity
C1J02_RS04210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1J02_RS04215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1J02_RS04220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1J02_RS04245	COG1047	Peptidyl-prolyl cis-trans
C1J02_RS04265	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1J02_RS04270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1J02_RS04280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1J02_RS04305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1J02_RS04320	COG1702	phosphate starvation-inducible protein PhoH
C1J02_RS04325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1J02_RS04330	COG1253	flavin adenine dinucleotide binding
C1J02_RS04335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1J02_RS04340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1J02_RS04350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1J02_RS04355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1J02_RS04365	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1J02_RS04375	COG2378	regulation of single-species biofilm formation
C1J02_RS04400	COG0539	negative regulation of cytoplasmic translation
C1J02_RS04405	COG0776	regulation of translation
C1J02_RS04415	COG0135	phosphoribosylanthranilate isomerase activity
C1J02_RS04425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1J02_RS04440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1J02_RS04480	COG2943	transferase activity, transferring hexosyl groups
C1J02_RS04485	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C1J02_RS04500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J02_RS04505	COG0028	Belongs to the TPP enzyme family
C1J02_RS04520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1J02_RS04540	COG3246	L-lysine catabolic process to acetate
C1J02_RS04550	COG0824	Thioesterase
C1J02_RS04550	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J02_RS04555	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS04575	COG0306	phosphate transporter
C1J02_RS04585	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1J02_RS04590	COG0101	tRNA pseudouridine synthase activity
C1J02_RS04595	COG3106	COG3106 Predicted ATPase
C1J02_RS04605	COG3768	UPF0283 membrane protein
C1J02_RS04615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1J02_RS04620	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C1J02_RS04625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1J02_RS04635	COG1183	phosphatidylcholine synthase activity
C1J02_RS04645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1J02_RS04660	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1J02_RS04665	COG0583	DNA-binding transcription factor activity
C1J02_RS04670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1J02_RS04675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1J02_RS04680	COG0424	maF-like protein
C1J02_RS04685	COG1530	ribonuclease E activity
C1J02_RS04690	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C1J02_RS04765	COG2010	Cytochrome c
C1J02_RS04770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1J02_RS04780	COG2963	transposase activity
C1J02_RS04885	COG5002	protein histidine kinase activity
C1J02_RS04890	COG0745	RESPONSE REGULATOR receiver
C1J02_RS04900	COG0745	RESPONSE REGULATOR receiver
C1J02_RS04910	COG1469	GTP cyclohydrolase I activity
C1J02_RS04920	COG5002	protein histidine kinase activity
C1J02_RS04960	COG4974	Belongs to the 'phage' integrase family
C1J02_RS05005	COG3474	cytochrome
C1J02_RS05010	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1J02_RS05015	COG0408	coproporphyrinogen oxidase activity
C1J02_RS05020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1J02_RS05035	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C1J02_RS05040	COG1088	dTDP-glucose 4,6-dehydratase activity
C1J02_RS05045	COG1091	dTDP-4-dehydrorhamnose reductase activity
C1J02_RS05090	COG0789	Transcriptional regulator
C1J02_RS05120	COG0784	Response regulator, receiver
C1J02_RS05120	COG4191	Histidine kinase
C1J02_RS05155	COG1136	(ABC) transporter
C1J02_RS05190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1J02_RS05195	COG1127	ABC transporter
C1J02_RS05210	COG0582	viral genome integration into host DNA
C1J02_RS05220	COG2226	methyltransferase
C1J02_RS05235	COG2226	methyltransferase
C1J02_RS05260	COG0588	phosphoglycerate mutase activity
C1J02_RS05270	COG2226	methyltransferase
C1J02_RS05305	COG2226	methyltransferase
C1J02_RS05320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C1J02_RS05350	COG1733	regulation of RNA biosynthetic process
C1J02_RS05370	COG2897	thiosulfate sulfurtransferase activity
C1J02_RS05405	COG1175	transmembrane transport
C1J02_RS05410	COG0395	ABC-type sugar transport system, permease component
C1J02_RS05415	COG3842	ATPase activity
C1J02_RS05430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J02_RS05440	COG3845	ABC transporter
C1J02_RS05445	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1J02_RS05450	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1J02_RS05455	COG0402	S-adenosylhomocysteine deaminase activity
C1J02_RS05470	COG0129	dihydroxy-acid dehydratase activity
C1J02_RS05475	COG0800	Aldolase
C1J02_RS05495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1J02_RS05500	COG0165	Argininosuccinate lyase
C1J02_RS05515	COG0019	diaminopimelate decarboxylase activity
C1J02_RS05530	COG2884	Cell division ATP-binding protein ftsE
C1J02_RS05570	COG0346	lactoylglutathione lyase activity
C1J02_RS05575	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J02_RS05580	COG0567	Dehydrogenase, E1 component
C1J02_RS05600	COG0045	succinate-CoA ligase (ADP-forming) activity
C1J02_RS05615	COG2030	dehydratase
C1J02_RS05630	COG2301	Belongs to the HpcH HpaI aldolase family
C1J02_RS05650	COG0039	L-malate dehydrogenase activity
C1J02_RS05700	COG0813	purine-nucleoside phosphorylase activity
C1J02_RS05715	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J02_RS05715	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J02_RS05720	COG2937	Belongs to the GPAT DAPAT family
C1J02_RS05725	COG0604	alcohol dehydrogenase
C1J02_RS05745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1J02_RS05750	COG4221	oxidoreductase activity
C1J02_RS05760	COG0730	response to heat
C1J02_RS05765	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1J02_RS05770	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1J02_RS05775	COG3845	ABC transporter
C1J02_RS05780	COG1744	ABC transporter substrate-binding protein PnrA-like
C1J02_RS05795	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1J02_RS05830	COG1272	protein, Hemolysin III
C1J02_RS05845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1J02_RS05855	COG0133	tryptophan synthase activity
C1J02_RS05880	COG0193	aminoacyl-tRNA hydrolase activity
C1J02_RS05895	COG3254	rhamnose metabolic process
C1J02_RS05910	COG1238	metal cluster binding
C1J02_RS05930	COG2273	Hydrolase Family 16
C1J02_RS05935	COG3307	-O-antigen
C1J02_RS05945	COG1596	polysaccharide export
C1J02_RS05950	COG0438	transferase activity, transferring glycosyl groups
C1J02_RS05960	COG1215	transferase activity, transferring glycosyl groups
C1J02_RS05965	COG1215	transferase activity, transferring glycosyl groups
C1J02_RS05975	COG1215	transferase activity, transferring glycosyl groups
C1J02_RS06020	COG0673	inositol 2-dehydrogenase activity
C1J02_RS06035	COG0024	Methionine aminopeptidase
C1J02_RS06045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1J02_RS06090	COG1643	Atp-dependent helicase
C1J02_RS06095	COG1703	isobutyryl-CoA mutase activity
C1J02_RS06110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1J02_RS06150	COG0632	four-way junction helicase activity
C1J02_RS06155	COG2255	four-way junction helicase activity
C1J02_RS06165	COG0824	Thioesterase
C1J02_RS06185	COG0823	Involved in the tonB-independent uptake of proteins
C1J02_RS06190	COG2885	chlorophyll binding
C1J02_RS06200	COG0037	tRNA processing
C1J02_RS06205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1J02_RS06215	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1J02_RS06220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1J02_RS06235	COG1201	RNA secondary structure unwinding
C1J02_RS06285	COG4964	Belongs to the GSP D family
C1J02_RS06310	COG0741	lytic transglycosylase activity
C1J02_RS06330	COG1754	DNA topoisomerase type I activity
C1J02_RS06330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1J02_RS06335	COG0758	DNA mediated transformation
C1J02_RS06340	COG0312	modulator of DNA gyrase
C1J02_RS06350	COG0109	protoheme IX farnesyltransferase activity
C1J02_RS06360	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C1J02_RS06370	COG3346	SURF1 family
C1J02_RS06380	COG0612	Peptidase, M16
C1J02_RS06395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1J02_RS06420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1J02_RS06425	COG1280	lysine exporter protein (LysE YggA)
C1J02_RS06430	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C1J02_RS06435	COG0659	secondary active sulfate transmembrane transporter activity
C1J02_RS06445	COG1959	2 iron, 2 sulfur cluster binding
C1J02_RS06450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1J02_RS06470	COG4149	molybdate abc transporter
C1J02_RS06475	COG0725	ABC transporter, periplasmic molybdate-binding protein
C1J02_RS06490	COG0300	oxidoreductase activity
C1J02_RS06500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1J02_RS06515	COG1228	amidohydrolase
C1J02_RS06520	COG2986	histidine ammonia-lyase
C1J02_RS06530	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1J02_RS06560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1J02_RS06575	COG1492	cobalamin metabolic process
C1J02_RS06585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1J02_RS06590	COG0354	folic acid binding
C1J02_RS06600	COG1132	(ABC) transporter
C1J02_RS06615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1J02_RS06630	COG0525	valine-tRNA ligase activity
C1J02_RS06680	COG0583	DNA-binding transcription factor activity
C1J02_RS06685	COG0483	inositol monophosphate 1-phosphatase activity
C1J02_RS06705	COG1522	sequence-specific DNA binding
C1J02_RS06720	COG0666	response to abiotic stimulus
C1J02_RS06740	COG0306	phosphate transporter
C1J02_RS06755	COG2197	response regulator
C1J02_RS06765	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS06770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1J02_RS06780	COG2267	carboxylic ester hydrolase activity
C1J02_RS06790	COG2188	Transcriptional regulator
C1J02_RS06805	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C1J02_RS06825	COG4336	lyase activity
C1J02_RS06830	COG0583	DNA-binding transcription factor activity
C1J02_RS06840	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C1J02_RS06845	COG0840	transmembrane signaling receptor activity
C1J02_RS06850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1J02_RS06860	COG0667	Aldo Keto reductase
C1J02_RS06920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1J02_RS06925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1J02_RS06925	COG2169	Transcriptional regulator
C1J02_RS06930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J02_RS06935	COG4311	Sarcosine oxidase, delta subunit
C1J02_RS06940	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J02_RS06940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J02_RS06955	COG0358	DNA primase activity
C1J02_RS06960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1J02_RS06980	COG0432	Pfam Uncharacterised protein family UPF0047
C1J02_RS06990	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1J02_RS06995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1J02_RS06995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1J02_RS07020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1J02_RS07020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1J02_RS07025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1J02_RS07030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1J02_RS07085	COG0564	pseudouridine synthase activity
C1J02_RS07095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1J02_RS07110	COG0456	acetyltransferase
C1J02_RS07110	COG0454	-acetyltransferase
C1J02_RS07120	COG1793	dna ligase
C1J02_RS07155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1J02_RS07160	COG1329	Transcriptional regulator
C1J02_RS07165	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1J02_RS07170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1J02_RS07180	COG1522	sequence-specific DNA binding
C1J02_RS07220	COG3608	succinylglutamate desuccinylase aspartoacylase
C1J02_RS07235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1J02_RS07270	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J02_RS07270	COG0022	dehydrogenase e1 component
C1J02_RS07275	COG0022	dehydrogenase e1 component
C1J02_RS07280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1J02_RS07285	COG0006	proline dipeptidase activity
C1J02_RS07300	COG1879	ABC-type sugar transport system periplasmic component
C1J02_RS07305	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS07310	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1J02_RS07315	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1J02_RS07320	COG1129	ABC transporter
C1J02_RS07355	COG1475	DNA binding
C1J02_RS07370	COG0251	oxidation-reduction process
C1J02_RS07390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS07395	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J02_RS07395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J02_RS07490	COG0668	transmembrane transport
C1J02_RS07515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1J02_RS07525	COG1832	CoA-binding protein
C1J02_RS07530	COG0140	phosphoribosyl-ATP diphosphatase activity
C1J02_RS07535	COG0107	imidazoleglycerol-phosphate synthase activity
C1J02_RS07540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1J02_RS07555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1J02_RS07560	COG0131	Imidazoleglycerol-phosphate dehydratase
C1J02_RS07650	COG0321	lipoyl(octanoyl) transferase activity
C1J02_RS07700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1J02_RS07725	COG0628	permease
C1J02_RS07745	COG2132	Multicopper oxidase
C1J02_RS07770	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C1J02_RS07775	COG0583	DNA-binding transcription factor activity
C1J02_RS07785	COG0765	amino acid transport
C1J02_RS07790	COG0765	amino acid transport
C1J02_RS07795	COG1126	abc transporter atp-binding protein
C1J02_RS07800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1J02_RS07810	COG2010	Cytochrome c
C1J02_RS07810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1J02_RS07815	COG2080	2 iron, 2 sulfur cluster binding
C1J02_RS07855	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1J02_RS07870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J02_RS07875	COG1116	anion transmembrane transporter activity
C1J02_RS07890	COG0583	DNA-binding transcription factor activity
C1J02_RS07895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS07905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J02_RS07910	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J02_RS07910	COG0596	Alpha beta hydrolase
C1J02_RS07930	COG1733	regulation of RNA biosynthetic process
C1J02_RS07950	COG2084	Dehydrogenase
C1J02_RS07960	COG0251	oxidation-reduction process
C1J02_RS07970	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS07980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1J02_RS08005	COG0747	negative chemotaxis
C1J02_RS08010	COG0601	transmembrane transport
C1J02_RS08015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J02_RS08020	COG0444	Belongs to the ABC transporter superfamily
C1J02_RS08065	COG3459	Glycosyltransferase 36 associated
C1J02_RS08075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1J02_RS08080	COG0730	response to heat
C1J02_RS08105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1J02_RS08115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J02_RS08135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J02_RS08135	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J02_RS08175	COG5265	(ABC) transporter
C1J02_RS08185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1J02_RS08200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1J02_RS08205	COG1160	GTP binding
C1J02_RS08220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1J02_RS08225	COG1862	Preprotein translocase
C1J02_RS08230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1J02_RS08235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1J02_RS08245	COG3737	Protein of unknown function (DUF498/DUF598)
C1J02_RS08250	COG4133	protoheme IX ABC transporter activity
C1J02_RS08255	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1J02_RS08260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1J02_RS08270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1J02_RS08275	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1J02_RS08300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1J02_RS08335	COG3258	Cytochrome c
C1J02_RS08360	COG2258	MOSC domain
C1J02_RS08390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1J02_RS08400	COG2072	flavoprotein involved in K transport
C1J02_RS08420	COG0006	proline dipeptidase activity
C1J02_RS08465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1J02_RS08470	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1J02_RS08505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1J02_RS08505	COG0321	lipoyl(octanoyl) transferase activity
C1J02_RS08510	COG0084	hydrolase, TatD family'
C1J02_RS08525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1J02_RS08530	COG1686	Belongs to the peptidase S11 family
C1J02_RS08580	COG0174	glutamine synthetase
C1J02_RS08585	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS08595	COG1177	transmembrane transport
C1J02_RS08600	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J02_RS08605	COG3842	ATPase activity
C1J02_RS08620	COG1757	Na H antiporter
C1J02_RS08640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS08645	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J02_RS08650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J02_RS08650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J02_RS08655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1J02_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS08700	COG0348	domain, Protein
C1J02_RS08725	COG0583	DNA-binding transcription factor activity
C1J02_RS08745	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1J02_RS08750	COG0559	Belongs to the binding-protein-dependent transport system permease family
C1J02_RS08760	COG0829	nickel cation binding
C1J02_RS08765	COG0831	urea catabolic process
C1J02_RS08770	COG0832	Belongs to the urease beta subunit family
C1J02_RS08775	COG0804	urea catabolic process
C1J02_RS08780	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C1J02_RS08785	COG0830	nickel cation binding
C1J02_RS08790	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1J02_RS08810	COG2010	Cytochrome c
C1J02_RS08835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1J02_RS08840	COG0668	transmembrane transport
C1J02_RS08860	COG3448	diguanylate cyclase activity
C1J02_RS08860	COG4175	Glycine betaine
C1J02_RS08905	COG0745	RESPONSE REGULATOR receiver
C1J02_RS08915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1J02_RS08915	COG2111	Na H antiporter
C1J02_RS08920	COG1006	Multisubunit Na H antiporter MnhC subunit
C1J02_RS08925	COG0651	ATP synthesis coupled electron transport
C1J02_RS08930	COG1863	multisubunit Na H antiporter MnhE subunit
C1J02_RS08935	COG2212	antiporter activity
C1J02_RS08940	COG1320	monovalent cation:proton antiporter activity
C1J02_RS08945	COG1295	ribonuclease BN
C1J02_RS08955	COG2855	membrane
C1J02_RS08960	COG0028	Belongs to the TPP enzyme family
C1J02_RS08965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J02_RS08980	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J02_RS08980	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J02_RS08990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS08995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1J02_RS09020	COG0456	acetyltransferase
C1J02_RS09100	COG3608	succinylglutamate desuccinylase aspartoacylase
C1J02_RS09100	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C1J02_RS09115	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C1J02_RS09130	COG1672	PFAM Archaeal ATPase
C1J02_RS09130	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1J02_RS09155	COG1522	sequence-specific DNA binding
C1J02_RS09160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J02_RS09175	COG0318	PFAM AMP-dependent synthetase and ligase
C1J02_RS09220	COG3386	PFAM SMP-30 Gluconolaconase
C1J02_RS09225	COG0800	Aldolase
C1J02_RS09230	COG3734	2-keto-3-deoxy-galactonokinase
C1J02_RS09235	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS09240	COG1486	melibiose metabolic process
C1J02_RS09245	COG0395	ABC-type sugar transport system, permease component
C1J02_RS09250	COG1175	transmembrane transport
C1J02_RS09260	COG1414	Transcriptional regulator
C1J02_RS09275	COG1846	Transcriptional regulator
C1J02_RS09280	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J02_RS09280	COG1024	Enoyl-CoA hydratase
C1J02_RS09285	COG1960	acyl-CoA dehydrogenase activity
C1J02_RS09295	COG3483	tryptophan 2,3-dioxygenase activity
C1J02_RS09310	COG3485	protocatechuate 3,4-dioxygenase
C1J02_RS09315	COG3485	protocatechuate 3,4-dioxygenase
C1J02_RS09325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1J02_RS09330	COG1121	(ABC) transporter
C1J02_RS09340	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1J02_RS09350	COG2391	methyltransferase activity
C1J02_RS09370	COG0785	Cytochrome C biogenesis protein
C1J02_RS09395	COG3258	Cytochrome c
C1J02_RS09400	COG0737	Belongs to the 5'-nucleotidase family
C1J02_RS09405	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1J02_RS09415	COG0740	serine-type endopeptidase activity
C1J02_RS09420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1J02_RS09445	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1J02_RS09450	COG0439	Biotin carboxylase
C1J02_RS09460	COG0410	ABC transporter
C1J02_RS09485	COG3800	Transcriptional regulator
C1J02_RS09485	COG1396	sequence-specific DNA binding
C1J02_RS09500	COG5002	protein histidine kinase activity
C1J02_RS09535	COG3750	Belongs to the UPF0335 family
C1J02_RS09540	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1J02_RS09545	COG0737	Belongs to the 5'-nucleotidase family
C1J02_RS09550	COG0739	heme binding
C1J02_RS09550	COG1196	nuclear chromosome segregation
C1J02_RS09550	COG0741	lytic transglycosylase activity
C1J02_RS09555	COG0359	binds to the 23S rRNA
C1J02_RS09560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1J02_RS09565	COG0360	Binds together with S18 to 16S ribosomal RNA
C1J02_RS09580	COG3038	cytochrome b561
C1J02_RS09585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1J02_RS09600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1J02_RS09610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1J02_RS09615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1J02_RS09640	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J02_RS09645	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J02_RS09645	COG0022	dehydrogenase e1 component
C1J02_RS09650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1J02_RS09670	COG0126	phosphoglycerate kinase activity
C1J02_RS09690	COG0739	heme binding
C1J02_RS09695	COG2833	Protein of unknown function (DUF455)
C1J02_RS09700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1J02_RS09710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1J02_RS09725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1J02_RS09730	COG2226	methyltransferase
C1J02_RS09745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1J02_RS09770	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1J02_RS09795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1J02_RS09810	COG2354	Protein conserved in bacteria
C1J02_RS09815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1J02_RS09830	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1J02_RS09840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C1J02_RS09865	COG2885	chlorophyll binding
C1J02_RS09870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1J02_RS09890	COG0175	sulfate reduction
C1J02_RS09905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1J02_RS09905	COG1648	precorrin-2 dehydrogenase activity
C1J02_RS09910	COG1522	sequence-specific DNA binding
C1J02_RS09920	COG2124	cytochrome p450
C1J02_RS09935	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS09940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J02_RS09945	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J02_RS09950	COG0149	triose-phosphate isomerase activity
C1J02_RS09980	COG2151	metal-sulfur cluster biosynthetic enzyme
C1J02_RS09990	COG4067	protein conserved in archaea
C1J02_RS09990	COG0189	ligase activity
C1J02_RS10005	COG0343	queuine tRNA-ribosyltransferase activity
C1J02_RS10015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1J02_RS10020	COG0776	regulation of translation
C1J02_RS10030	COG0406	alpha-ribazole phosphatase activity
C1J02_RS10035	COG0406	alpha-ribazole phosphatase activity
C1J02_RS10070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J02_RS10075	COG2814	Major facilitator Superfamily
C1J02_RS10085	COG0156	8-amino-7-oxononanoate synthase activity
C1J02_RS10095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1J02_RS10115	COG0436	Aminotransferase
C1J02_RS10120	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1J02_RS10125	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1J02_RS10130	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1J02_RS10135	COG0154	amidase activity
C1J02_RS10150	COG4638	Rieske (2fe-2S)
C1J02_RS10165	COG0440	acetolactate synthase activity
C1J02_RS10170	COG0028	Belongs to the TPP enzyme family
C1J02_RS10175	COG0840	transmembrane signaling receptor activity
C1J02_RS10190	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J02_RS10205	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C1J02_RS10225	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1J02_RS10245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1J02_RS10255	COG0501	Belongs to the peptidase M48B family
C1J02_RS10280	COG0542	response to heat
C1J02_RS10290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1J02_RS10300	COG0010	Belongs to the arginase family
C1J02_RS10310	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1J02_RS10315	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1J02_RS10320	COG1238	metal cluster binding
C1J02_RS10340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1J02_RS10365	COG4536	flavin adenine dinucleotide binding
C1J02_RS10375	COG4974	Belongs to the 'phage' integrase family
C1J02_RS10385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1J02_RS10390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1J02_RS10400	COG0629	single-stranded DNA binding
C1J02_RS10405	COG0741	lytic transglycosylase activity
C1J02_RS10405	COG0739	heme binding
C1J02_RS10405	COG1196	nuclear chromosome segregation
C1J02_RS10415	COG4172	Belongs to the ABC transporter superfamily
C1J02_RS10420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J02_RS10425	COG0601	transmembrane transport
C1J02_RS10435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1J02_RS10440	COG0528	UMP kinase activity
C1J02_RS10445	COG0233	cytoplasmic translational termination
C1J02_RS10450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1J02_RS10460	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1J02_RS10465	COG0750	zinc metalloprotease
C1J02_RS10470	COG3046	protein related to deoxyribodipyrimidine photolyase
C1J02_RS10475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1J02_RS10485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1J02_RS10490	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1J02_RS10500	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1J02_RS10505	COG0482	sulfurtransferase activity
C1J02_RS10515	COG0745	RESPONSE REGULATOR receiver
C1J02_RS10520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1J02_RS10525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1J02_RS10535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1J02_RS10545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1J02_RS10550	COG2226	methyltransferase
C1J02_RS10555	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C1J02_RS10560	COG1024	Enoyl-CoA hydratase
C1J02_RS10575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1J02_RS10580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1J02_RS10590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1J02_RS10600	COG1309	transcriptional regulator
C1J02_RS10605	COG2326	polyphosphate kinase activity
C1J02_RS10610	COG0596	Alpha beta hydrolase
C1J02_RS10615	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C1J02_RS10635	COG0697	spore germination
C1J02_RS10645	COG5598	trimethylamine methyltransferase
C1J02_RS10665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1J02_RS10670	COG2010	Cytochrome c
C1J02_RS10680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C1J02_RS10685	COG2867	negative regulation of translational initiation
C1J02_RS10695	COG0004	ammonium transporteR
C1J02_RS10700	COG1058	Belongs to the CinA family
C1J02_RS10700	COG1546	Belongs to the CinA family
C1J02_RS10705	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1J02_RS10710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1J02_RS10710	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1J02_RS10715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1J02_RS10720	COG3852	Histidine kinase
C1J02_RS10725	COG2204	response regulator
C1J02_RS10730	COG5000	phosphorelay sensor kinase activity
C1J02_RS10735	COG2204	response regulator
C1J02_RS10750	COG0569	domain protein
C1J02_RS10755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1J02_RS10760	COG1923	regulation of RNA biosynthetic process
C1J02_RS10765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1J02_RS10775	COG1187	pseudouridine synthase activity
C1J02_RS10780	COG2366	antibiotic biosynthetic process
C1J02_RS10785	COG2084	Dehydrogenase
C1J02_RS10830	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1J02_RS10840	COG2814	Major facilitator Superfamily
C1J02_RS10865	COG1396	sequence-specific DNA binding
C1J02_RS10880	COG4166	transmembrane transport
C1J02_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS10900	COG2313	pseudouridylate synthase activity
C1J02_RS10930	COG1612	heme a metabolic process
C1J02_RS10935	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C1J02_RS10940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1J02_RS10945	COG5425	PFAM Usg family protein
C1J02_RS10955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1J02_RS10965	COG0166	Belongs to the GPI family
C1J02_RS10985	COG0318	PFAM AMP-dependent synthetase and ligase
C1J02_RS11020	COG4106	trans-aconitate 2-methyltransferase activity
C1J02_RS11030	COG0516	GMP reductase activity
C1J02_RS11030	COG0517	IMP dehydrogenase activity
C1J02_RS11035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1J02_RS11050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1J02_RS11055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1J02_RS11065	COG1217	gtp-binding protein TYPA
C1J02_RS11070	COG0668	transmembrane transport
C1J02_RS11075	COG2076	Multidrug Resistance protein
C1J02_RS11080	COG1522	sequence-specific DNA binding
C1J02_RS11095	COG0538	isocitrate dehydrogenase activity
C1J02_RS11115	COG2945	thiolester hydrolase activity
C1J02_RS11120	COG1959	2 iron, 2 sulfur cluster binding
C1J02_RS11130	COG0719	Fe-S assembly protein
C1J02_RS11140	COG0396	ATPase activity
C1J02_RS11145	COG0719	Fe-S assembly protein
C1J02_RS11160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1J02_RS11175	COG3813	Protein conserved in bacteria
C1J02_RS11195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1J02_RS11215	COG0433	COG0433 Predicted ATPase
C1J02_RS11250	COG2133	pyrroloquinoline quinone binding
C1J02_RS11260	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C1J02_RS11270	COG1561	YicC-like family, N-terminal region
C1J02_RS11275	COG0194	GDP metabolic process
C1J02_RS11285	COG5002	protein histidine kinase activity
C1J02_RS11295	COG0573	inorganic phosphate transmembrane transporter activity
C1J02_RS11305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1J02_RS11315	COG0745	RESPONSE REGULATOR receiver
C1J02_RS11320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1J02_RS11325	COG2771	luxR family
C1J02_RS11335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1J02_RS11340	COG0052	Belongs to the universal ribosomal protein uS2 family
C1J02_RS11370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1J02_RS11375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1J02_RS11380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1J02_RS11400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1J02_RS11405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1J02_RS11405	COG3743	rRNA binding
C1J02_RS11430	COG0189	ligase activity
C1J02_RS11430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1J02_RS11440	COG0006	proline dipeptidase activity
C1J02_RS11455	COG0006	proline dipeptidase activity
C1J02_RS11465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J02_RS11470	COG3842	ATPase activity
C1J02_RS11480	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J02_RS11495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1J02_RS11500	COG0248	Ppx GppA phosphatase
C1J02_RS11510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1J02_RS11525	COG0643	Histidine kinase
C1J02_RS11525	COG2198	Histidine kinase
C1J02_RS11525	COG0784	Response regulator, receiver
C1J02_RS11535	COG0835	chemotaxis
C1J02_RS11540	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1J02_RS11545	COG0745	RESPONSE REGULATOR receiver
C1J02_RS11560	COG2201	protein-glutamate methylesterase activity
C1J02_RS11565	COG1349	DNA-binding transcription factor activity
C1J02_RS11575	COG3842	ATPase activity
C1J02_RS11580	COG3842	ATPase activity
C1J02_RS11590	COG0395	ABC-type sugar transport system, permease component
C1J02_RS11605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1J02_RS11610	COG1454	alcohol dehydrogenase
C1J02_RS11620	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1J02_RS11625	COG0483	inositol monophosphate 1-phosphatase activity
C1J02_RS11635	COG0395	ABC-type sugar transport system, permease component
C1J02_RS11640	COG1175	transmembrane transport
C1J02_RS11645	COG1653	transport
C1J02_RS11655	COG1349	DNA-binding transcription factor activity
C1J02_RS11675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1J02_RS11680	COG3264	Mechanosensitive ion channel
C1J02_RS11680	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1J02_RS11690	COG0494	nUDIX hydrolase
C1J02_RS11700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1J02_RS11705	COG0415	Belongs to the DNA photolyase family
C1J02_RS11710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1J02_RS11715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1J02_RS11725	COG3273	potassium ion transport
C1J02_RS11725	COG0471	metal ion transport
C1J02_RS11730	COG0537	adenosine 5'-monophosphoramidase activity
C1J02_RS11740	COG0604	alcohol dehydrogenase
C1J02_RS11745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J02_RS11765	COG2186	Transcriptional regulator
C1J02_RS11785	COG2059	Chromate
C1J02_RS11795	COG0114	fumarate hydratase activity
C1J02_RS11815	COG3588	fructose-bisphosphate aldolase
C1J02_RS11820	COG2124	cytochrome p450
C1J02_RS11830	COG0785	Cytochrome C biogenesis protein
C1J02_RS11835	COG0425	Belongs to the sulfur carrier protein TusA family
C1J02_RS11840	COG1530	ribonuclease E activity
C1J02_RS11850	COG2204	response regulator
C1J02_RS11860	COG0047	phosphoribosylformylglycinamidine synthase activity
C1J02_RS11865	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1J02_RS11870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1J02_RS11880	COG1410	methionine synthase
C1J02_RS11880	COG0646	methionine synthase
C1J02_RS11900	COG5012	cobalamin binding
C1J02_RS11910	COG0393	Putative heavy-metal-binding
C1J02_RS11920	COG2166	iron-sulfur cluster assembly
C1J02_RS11930	COG0251	oxidation-reduction process
C1J02_RS11935	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1J02_RS11940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1J02_RS11945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1J02_RS12035	COG2897	thiosulfate sulfurtransferase activity
C1J02_RS12040	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C1J02_RS12045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1J02_RS12065	COG0668	transmembrane transport
C1J02_RS12075	COG1366	Belongs to the anti-sigma-factor antagonist family
C1J02_RS12080	COG1366	Belongs to the anti-sigma-factor antagonist family
C1J02_RS12095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1J02_RS12105	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1J02_RS12145	COG3012	SEC-C Motif Domain Protein
C1J02_RS12145	COG3318	Belongs to the UPF0149 family
C1J02_RS12170	COG2226	methyltransferase
C1J02_RS12195	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1J02_RS12205	COG4681	YaeQ
C1J02_RS12230	COG1280	lysine exporter protein (LysE YggA)
C1J02_RS12240	COG0625	glutathione transferase activity
C1J02_RS12255	COG2072	flavoprotein involved in K transport
C1J02_RS12260	COG2020	methyltransferase activity
C1J02_RS12265	COG1858	cytochrome C peroxidase
C1J02_RS12310	COG0346	lactoylglutathione lyase activity
C1J02_RS12320	COG1024	Enoyl-CoA hydratase
C1J02_RS12325	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS12330	COG1653	transport
C1J02_RS12335	COG1175	transmembrane transport
C1J02_RS12340	COG0395	ABC-type sugar transport system, permease component
C1J02_RS12345	COG3842	ATPase activity
C1J02_RS12365	COG1609	Transcriptional regulator
C1J02_RS12370	COG0673	inositol 2-dehydrogenase activity
C1J02_RS12375	COG1053	succinate dehydrogenase
C1J02_RS12395	COG1233	COG1233 Phytoene dehydrogenase and related
C1J02_RS12425	COG0105	UTP biosynthetic process
C1J02_RS12430	COG0488	(ABC) transporter
C1J02_RS12435	COG2095	MarC family integral membrane protein
C1J02_RS12440	COG3577	Aspartyl protease
C1J02_RS12450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1J02_RS12465	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1J02_RS12475	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1J02_RS12480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1J02_RS12505	COG2890	protein-(glutamine-N5) methyltransferase activity
C1J02_RS12510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1J02_RS12530	COG0010	Belongs to the arginase family
C1J02_RS12540	COG3956	TIGRFAM MazG family protein
C1J02_RS12550	COG0456	acetyltransferase
C1J02_RS12550	COG0454	-acetyltransferase
C1J02_RS12555	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C1J02_RS12575	COG0513	Belongs to the DEAD box helicase family
C1J02_RS12605	COG0148	phosphopyruvate hydratase activity
C1J02_RS12625	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1J02_RS12630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1J02_RS12645	COG0110	maltose O-acetyltransferase activity
C1J02_RS12650	COG0488	(ABC) transporter
C1J02_RS12670	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1J02_RS12675	COG0416	fatty acid biosynthetic process
C1J02_RS12680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1J02_RS12685	COG0776	regulation of translation
C1J02_RS12700	COG0717	Belongs to the dCTP deaminase family
C1J02_RS12710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1J02_RS12715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C1J02_RS12720	COG1472	Belongs to the glycosyl hydrolase 3 family
C1J02_RS12730	COG0018	arginyl-trna synthetase
C1J02_RS12740	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1J02_RS12795	COG2099	Precorrin-6x reductase
C1J02_RS12800	COG2814	Major facilitator Superfamily
C1J02_RS12815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1J02_RS12820	COG0215	cysteine-tRNA ligase activity
C1J02_RS12840	COG1280	lysine exporter protein (LysE YggA)
C1J02_RS12870	COG3257	ureidoglycine aminohydrolase activity
C1J02_RS12875	COG1414	Transcriptional regulator
C1J02_RS12880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1J02_RS12885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1J02_RS12890	COG3616	Alanine racemase, N-terminal domain
C1J02_RS12895	COG2423	ornithine cyclodeaminase activity
C1J02_RS12905	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C1J02_RS12915	COG2351	hydroxyisourate hydrolase activity
C1J02_RS12930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1J02_RS12945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1J02_RS12960	COG1278	Cold shock
C1J02_RS12965	COG0259	pyridoxamine-phosphate oxidase activity
C1J02_RS12970	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1J02_RS12975	COG1280	lysine exporter protein (LysE YggA)
C1J02_RS12985	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C1J02_RS12990	COG0436	Aminotransferase
C1J02_RS13000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1J02_RS13025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1J02_RS13030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1J02_RS13035	COG0134	indole-3-glycerol-phosphate synthase activity
C1J02_RS13040	COG0315	cyclic pyranopterin monophosphate synthase activity
C1J02_RS13045	COG0303	'Molybdopterin
C1J02_RS13050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1J02_RS13055	COG2333	competence protein COMEC
C1J02_RS13055	COG0658	competence protein
C1J02_RS13060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1J02_RS13065	COG0372	Belongs to the citrate synthase family
C1J02_RS13075	COG1024	Enoyl-CoA hydratase
C1J02_RS13080	COG3088	subunit of a heme lyase
C1J02_RS13085	COG1138	Cytochrome C-type biogenesis protein
C1J02_RS13100	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C1J02_RS13105	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1J02_RS13110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1J02_RS13140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1J02_RS13185	COG0418	dihydroorotase activity
C1J02_RS13190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1J02_RS13195	COG0305	Participates in initiation and elongation during chromosome replication
C1J02_RS13210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1J02_RS13230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1J02_RS13250	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C1J02_RS13255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1J02_RS13270	COG0805	protein transport
C1J02_RS13275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1J02_RS13280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1J02_RS13290	COG2378	regulation of single-species biofilm formation
C1J02_RS13315	COG4335	DNA alkylation repair
C1J02_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS13330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C1J02_RS13340	COG0513	Belongs to the DEAD box helicase family
C1J02_RS13355	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C1J02_RS13365	COG1007	ATP synthesis coupled electron transport
C1J02_RS13385	COG0713	ATP synthesis coupled electron transport
C1J02_RS13400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1J02_RS13405	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1J02_RS13470	COG3743	rRNA binding
C1J02_RS13470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1J02_RS13480	COG0649	NAD binding
C1J02_RS13485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1J02_RS13495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1J02_RS13515	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1J02_RS13545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1J02_RS13555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1J02_RS13565	COG1960	acyl-CoA dehydrogenase activity
C1J02_RS13580	COG0546	phosphoglycolate phosphatase activity
C1J02_RS13585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1J02_RS13610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1J02_RS13615	COG1519	Transferase
C1J02_RS13620	COG0438	transferase activity, transferring glycosyl groups
C1J02_RS13625	COG1473	amidohydrolase
C1J02_RS13630	COG1473	amidohydrolase
C1J02_RS13635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J02_RS13640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J02_RS13645	COG4172	Belongs to the ABC transporter superfamily
C1J02_RS13655	COG0601	transmembrane transport
C1J02_RS13660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J02_RS13675	COG0534	Mate efflux family protein
C1J02_RS13680	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1J02_RS13695	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS13700	COG1943	Transposase
C1J02_RS13705	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1J02_RS13715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1J02_RS13725	COG0308	aminopeptidase N
C1J02_RS13750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1J02_RS13765	COG0484	heat shock protein binding
C1J02_RS13780	COG0006	proline dipeptidase activity
C1J02_RS13790	COG0038	chloride channel
C1J02_RS13795	COG0497	DNA recombination
C1J02_RS13800	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1J02_RS13805	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1J02_RS13810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1J02_RS13815	COG0849	cell division
C1J02_RS13820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1J02_RS13825	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1J02_RS13830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1J02_RS13850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1J02_RS13855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1J02_RS13865	COG2081	HI0933 family
C1J02_RS13870	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1J02_RS13875	COG2066	Belongs to the glutaminase family
C1J02_RS13880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1J02_RS13890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1J02_RS13905	COG0275	rRNA processing
C1J02_RS13910	COG2001	Belongs to the MraZ family
C1J02_RS13920	COG0489	protein tyrosine kinase activity
C1J02_RS13935	COG0210	DNA helicase
C1J02_RS13945	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C1J02_RS13955	COG0346	lactoylglutathione lyase activity
C1J02_RS13975	COG1610	YqeY-like protein
C1J02_RS13980	COG0505	Belongs to the CarA family
C1J02_RS13990	COG1802	Transcriptional regulator
C1J02_RS14015	COG1522	sequence-specific DNA binding
C1J02_RS14020	COG1522	sequence-specific DNA binding
C1J02_RS14025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1J02_RS14035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1J02_RS14040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1J02_RS14045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1J02_RS14055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1J02_RS14055	COG0574	Belongs to the PEP-utilizing enzyme family
C1J02_RS14060	COG0751	glycine-tRNA ligase activity
C1J02_RS14075	COG0752	glycyl-tRNA synthetase alpha subunit
C1J02_RS14090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1J02_RS14100	COG1469	GTP cyclohydrolase I activity
C1J02_RS14110	COG0625	glutathione transferase activity
C1J02_RS14125	COG0552	protein localization to endoplasmic reticulum
C1J02_RS14130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1J02_RS14150	COG0151	Belongs to the GarS family
C1J02_RS14185	COG0330	HflC and HflK could
C1J02_RS14200	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C1J02_RS14210	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1J02_RS14220	COG1760	l-serine dehydratase
C1J02_RS14235	COG1741	Belongs to the pirin family
C1J02_RS14275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1J02_RS14300	COG0297	glycogen (starch) synthase activity
C1J02_RS14300	COG0438	transferase activity, transferring glycosyl groups
C1J02_RS14325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1J02_RS14365	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS14370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1J02_RS14380	COG3447	MASE1 domain protein
C1J02_RS14380	COG5001	Diguanylate cyclase
C1J02_RS14380	COG5002	protein histidine kinase activity
C1J02_RS14440	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1J02_RS14470	COG0504	CTP synthase activity
C1J02_RS14475	COG0384	phenazine biosynthesis protein PhzF
C1J02_RS14480	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1J02_RS14515	COG4215	(ABC) transporter
C1J02_RS14520	COG4160	amino acid transport
C1J02_RS14525	COG0174	glutamine synthetase
C1J02_RS14530	COG0519	Catalyzes the synthesis of GMP from XMP
C1J02_RS14530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1J02_RS14535	COG0174	glutamine synthetase
C1J02_RS14540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J02_RS14545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1J02_RS14560	COG3243	poly(R)-hydroxyalkanoic acid synthase
C1J02_RS14610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1J02_RS14620	COG3220	belongs to the UPF0276 family
C1J02_RS14630	COG2259	Doxx family
C1J02_RS14635	COG1393	Belongs to the ArsC family
C1J02_RS14640	COG1278	Cold shock
C1J02_RS14655	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C1J02_RS14660	COG0346	lactoylglutathione lyase activity
C1J02_RS14675	COG1846	Transcriptional regulator
C1J02_RS14705	COG0534	Mate efflux family protein
C1J02_RS14720	COG2267	carboxylic ester hydrolase activity
C1J02_RS14730	COG0187	DNA topoisomerase II activity
C1J02_RS14760	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C1J02_RS14765	COG1136	(ABC) transporter
C1J02_RS14780	COG0442	prolyl-tRNA aminoacylation
C1J02_RS14785	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1J02_RS14800	COG0628	permease
C1J02_RS14810	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1J02_RS14815	COG0248	Ppx GppA phosphatase
C1J02_RS14835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1J02_RS14855	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J02_RS14855	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J02_RS14870	COG4770	biotin carboxylase activity
C1J02_RS14900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1J02_RS14905	COG2814	Major facilitator Superfamily
C1J02_RS14910	COG3800	Transcriptional regulator
C1J02_RS14910	COG1396	sequence-specific DNA binding
C1J02_RS14915	COG1525	nuclease
C1J02_RS14930	COG3119	arylsulfatase activity
C1J02_RS14935	COG1309	transcriptional regulator
C1J02_RS14960	COG0217	transcriptional regulatory protein
C1J02_RS14965	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1J02_RS14970	COG0471	metal ion transport
C1J02_RS14970	COG0490	domain, Protein
C1J02_RS14980	COG3273	potassium ion transport
C1J02_RS14980	COG0471	metal ion transport
C1J02_RS14990	COG1692	metallophosphoesterase
C1J02_RS15005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1J02_RS15010	COG2239	Acts as a magnesium transporter
C1J02_RS15015	COG0402	S-adenosylhomocysteine deaminase activity
C1J02_RS15030	COG0483	inositol monophosphate 1-phosphatase activity
C1J02_RS15040	COG0583	DNA-binding transcription factor activity
C1J02_RS15050	COG0670	Belongs to the BI1 family
C1J02_RS15075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1J02_RS15095	COG0154	amidase activity
C1J02_RS15100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1J02_RS15105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1J02_RS15120	COG0590	tRNA wobble adenosine to inosine editing
C1J02_RS15125	COG1187	pseudouridine synthase activity
C1J02_RS15135	COG3853	Toxic anion resistance protein (TelA)
C1J02_RS15165	COG1490	D-aminoacyl-tRNA deacylase activity
C1J02_RS15185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J02_RS15205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1J02_RS15210	COG0657	acetylesterase activity
C1J02_RS15215	COG0318	PFAM AMP-dependent synthetase and ligase
C1J02_RS15220	COG1652	LysM domain
C1J02_RS15225	COG1132	(ABC) transporter
C1J02_RS15240	COG1002	Type II restriction enzyme, methylase subunits
C1J02_RS15245	COG1061	Type III restriction enzyme res subunit
C1J02_RS15250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1J02_RS15270	COG0514	ATP-dependent DNA helicase (RecQ)
C1J02_RS15300	COG4681	YaeQ
C1J02_RS15305	COG1733	regulation of RNA biosynthetic process
C1J02_RS15320	COG4681	YaeQ
C1J02_RS15360	COG3152	Membrane
C1J02_RS15400	COG4983	Phage plasmid primase, P4 family domain protein
C1J02_RS15460	COG0701	Predicted permease
C1J02_RS15470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1J02_RS15530	COG1162	GTPase activity
C1J02_RS15545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1J02_RS15575	COG0437	4 iron, 4 sulfur cluster binding
C1J02_RS15580	COG3383	formate dehydrogenase (NAD+) activity
C1J02_RS15580	COG0243	molybdopterin cofactor binding
C1J02_RS15620	COG0489	protein tyrosine kinase activity
C1J02_RS15635	COG1126	abc transporter atp-binding protein
C1J02_RS15665	COG5598	trimethylamine methyltransferase
C1J02_RS15675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1J02_RS15675	COG2010	Cytochrome c
C1J02_RS15690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C1J02_RS15720	COG1522	sequence-specific DNA binding
C1J02_RS15745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1J02_RS15780	COG0714	Associated with various cellular activities
C1J02_RS15790	COG2010	Cytochrome c
C1J02_RS15805	COG3794	PFAM blue (type 1) copper domain protein
C1J02_RS15835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1J02_RS15840	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C1J02_RS15845	COG0124	histidyl-tRNA synthetase
C1J02_RS15860	COG2080	2 iron, 2 sulfur cluster binding
C1J02_RS15865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1J02_RS15875	COG3845	ABC transporter
C1J02_RS15880	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1J02_RS15885	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1J02_RS15915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1J02_RS15925	COG0277	FAD linked oxidase domain protein
C1J02_RS15960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1J02_RS15975	COG1672	PFAM Archaeal ATPase
C1J02_RS15975	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C1J02_RS16000	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS16005	COG0596	Alpha beta hydrolase
C1J02_RS16010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1J02_RS16015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS16020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J02_RS16100	COG1733	regulation of RNA biosynthetic process
C1J02_RS16110	COG1783	phage Terminase large subunit
C1J02_RS16120	COG1475	DNA binding
C1J02_RS16165	COG0154	amidase activity
C1J02_RS16195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS16230	COG0765	amino acid transport
C1J02_RS16235	COG0765	amino acid transport
C1J02_RS16245	COG1126	abc transporter atp-binding protein
C1J02_RS16250	COG0181	hydroxymethylbilane synthase activity
C1J02_RS16255	COG3002	Belongs to the UPF0753 family
C1J02_RS16260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1J02_RS16280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS16315	COG2205	protein histidine kinase activity
C1J02_RS16315	COG0784	Response regulator, receiver
C1J02_RS16350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J02_RS16360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS16365	COG1917	Cupin 2, conserved barrel domain protein
C1J02_RS16370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1J02_RS16375	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
C1J02_RS16390	COG1132	(ABC) transporter
C1J02_RS16420	COG2308	Evidence 4 Homologs of previously reported genes of
C1J02_RS16455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS16460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J02_RS16470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1J02_RS16475	COG4989	oxidoreductase activity
C1J02_RS16480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1J02_RS16490	COG0673	inositol 2-dehydrogenase activity
C1J02_RS16500	COG1840	ABC-type Fe3 transport system, periplasmic component
C1J02_RS16515	COG0483	inositol monophosphate 1-phosphatase activity
C1J02_RS16520	COG1858	cytochrome C peroxidase
C1J02_RS16535	COG4213	ABC transporter substrate-binding protein
C1J02_RS16540	COG4214	carbohydrate transport
C1J02_RS16545	COG1129	ABC transporter
C1J02_RS16550	COG2115	Belongs to the xylose isomerase family
C1J02_RS16595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1J02_RS16600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1J02_RS16605	COG2188	Transcriptional regulator
C1J02_RS16610	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C1J02_RS16620	COG1175	transmembrane transport
C1J02_RS16625	COG0395	ABC-type sugar transport system, permease component
C1J02_RS16630	COG0673	inositol 2-dehydrogenase activity
C1J02_RS16640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1J02_RS16670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1J02_RS16685	COG1960	acyl-CoA dehydrogenase activity
C1J02_RS16690	COG1960	acyl-CoA dehydrogenase activity
C1J02_RS16695	COG0183	Belongs to the thiolase family
C1J02_RS16700	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J02_RS16700	COG1024	Enoyl-CoA hydratase
C1J02_RS16710	COG4172	Belongs to the ABC transporter superfamily
C1J02_RS16715	COG0747	negative chemotaxis
C1J02_RS16720	COG0601	transmembrane transport
C1J02_RS16725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J02_RS16730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1J02_RS16735	COG0668	transmembrane transport
C1J02_RS16755	COG0438	transferase activity, transferring glycosyl groups
C1J02_RS16775	COG3246	L-lysine catabolic process to acetate
C1J02_RS16790	COG1943	Transposase
C1J02_RS16795	COG0481	GTPase activity
C1J02_RS16815	COG5328	Belongs to the UPF0262 family
C1J02_RS16820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1J02_RS16830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1J02_RS16855	COG2951	lytic endotransglycosylase activity
C1J02_RS16880	COG1192	Involved in chromosome partitioning
C1J02_RS16970	COG4948	Mandelate Racemase Muconate Lactonizing
C1J02_RS16975	COG1609	Transcriptional regulator
C1J02_RS16980	COG3265	gluconokinase activity
C1J02_RS16985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J02_RS17025	COG0556	nucleotide-excision repair
C1J02_RS17060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1J02_RS17065	COG1115	amino acid carrier protein
C1J02_RS17085	COG0488	(ABC) transporter
C1J02_RS17110	COG1278	Cold shock
C1J02_RS17115	COG1376	ErfK ybiS ycfS ynhG family protein
C1J02_RS17120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1J02_RS17125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J02_RS17130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J02_RS17160	COG1309	transcriptional regulator
C1J02_RS17175	COG0493	'glutamate synthase
C1J02_RS17190	COG4181	ATPase activity
C1J02_RS17200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1J02_RS17200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1J02_RS17205	COG0509	glycine decarboxylation via glycine cleavage system
C1J02_RS17210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J02_RS17225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1J02_RS17285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1J02_RS17315	COG0768	penicillin binding
C1J02_RS17320	COG0772	Belongs to the SEDS family
C1J02_RS17325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1J02_RS17330	COG0339	signal peptide processing
C1J02_RS17335	COG5507	3-demethylubiquinone-9 3-methyltransferase
C1J02_RS17340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1J02_RS17345	COG0756	dUTP diphosphatase activity
C1J02_RS17350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1J02_RS17375	COG0606	chelatase, subunit chli
C1J02_RS17385	COG0189	ligase activity
C1J02_RS17390	COG0792	nuclease activity
C1J02_RS17395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1J02_RS17405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1J02_RS17415	COG0277	FAD linked oxidase domain protein
C1J02_RS17450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J02_RS17555	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C1J02_RS17575	COG0583	DNA-binding transcription factor activity
C1J02_RS17580	COG0625	glutathione transferase activity
C1J02_RS17585	COG1017	nitric oxide dioxygenase activity
C1J02_RS17585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1J02_RS17600	COG4983	Phage plasmid primase, P4 family domain protein
C1J02_RS17635	COG0012	GTP binding
C1J02_RS17645	COG0159	tryptophan synthase activity
C1J02_RS17660	COG1304	FMN binding
C1J02_RS17670	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1J02_RS17675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J02_RS17695	COG0180	Tryptophanyl-tRNA synthetase
C1J02_RS17715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J02_RS17725	COG0747	negative chemotaxis
C1J02_RS17745	COG4172	Belongs to the ABC transporter superfamily
C1J02_RS17760	COG0747	negative chemotaxis
C1J02_RS17765	COG0154	amidase activity
C1J02_RS17770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J02_RS17780	COG4166	transmembrane transport
C1J02_RS17785	COG4608	Belongs to the ABC transporter superfamily
C1J02_RS17790	COG0444	Belongs to the ABC transporter superfamily
C1J02_RS17795	COG1802	Transcriptional regulator
C1J02_RS17880	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C1J02_RS17890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1J02_RS17900	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C1J02_RS17920	COG0284	orotidine-5'-phosphate decarboxylase activity
C1J02_RS17930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1J02_RS17945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1J02_RS17965	COG2205	protein histidine kinase activity
C1J02_RS17970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1J02_RS17980	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1J02_RS17985	COG0594	ribonuclease P activity
C1J02_RS17990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1J02_RS18000	COG0037	tRNA processing
C1J02_RS18005	COG5001	Diguanylate cyclase
C1J02_RS18010	COG0706	membrane insertase activity
C1J02_RS18020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1J02_RS18025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1J02_RS18040	COG1126	abc transporter atp-binding protein
C1J02_RS18045	COG0765	amino acid transport
C1J02_RS18050	COG4597	amino acid ABC transporter
C1J02_RS18055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1J02_RS18065	COG0546	phosphoglycolate phosphatase activity
C1J02_RS18070	COG0564	pseudouridine synthase activity
C1J02_RS18075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1J02_RS18080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1J02_RS18085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1J02_RS18090	COG0203	ribosomal protein L17
C1J02_RS18095	COG0202	RNA polymerase activity
C1J02_RS18100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1J02_RS18105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1J02_RS18110	COG0563	adenylate kinase activity
C1J02_RS18115	COG0201	protein transport
C1J02_RS18120	COG0200	Binds to the 23S rRNA
C1J02_RS18130	COG1841	ribosomal large subunit assembly
C1J02_RS18135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1J02_RS18140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1J02_RS18145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1J02_RS18150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1J02_RS18155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1J02_RS18160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1J02_RS18165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1J02_RS18170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1J02_RS18175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1J02_RS18180	COG0255	Belongs to the universal ribosomal protein uL29 family
C1J02_RS18200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1J02_RS18205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1J02_RS18210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1J02_RS18215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1J02_RS18220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1J02_RS18230	COG1278	Cold shock
C1J02_RS18235	COG0089	rRNA binding
C1J02_RS18240	COG0088	Forms part of the polypeptide exit tunnel
C1J02_RS18245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1J02_RS18250	COG0051	transcription antitermination factor activity, RNA binding
C1J02_RS18260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1J02_RS18265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1J02_RS18270	COG0049	tRNA binding
C1J02_RS18275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1J02_RS18285	COG0697	spore germination
C1J02_RS18295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1J02_RS18300	COG0085	RNA polymerase activity
C1J02_RS18305	COG0222	ribosome binding
C1J02_RS18310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1J02_RS18320	COG0081	regulation of translation
C1J02_RS18325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1J02_RS18330	COG0250	Participates in transcription elongation, termination and antitermination
C1J02_RS18360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1J02_RS18370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1J02_RS18370	COG2124	cytochrome p450
C1J02_RS18375	COG0501	Belongs to the peptidase M48B family
C1J02_RS18385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1J02_RS18395	COG0300	oxidoreductase activity
C1J02_RS18405	COG2096	Adenosyltransferase
C1J02_RS18430	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J02_RS18440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1J02_RS18450	COG1660	Displays ATPase and GTPase activities
C1J02_RS18460	COG2205	protein histidine kinase activity
C1J02_RS18465	COG0745	RESPONSE REGULATOR receiver
C1J02_RS18470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1J02_RS18485	COG1396	sequence-specific DNA binding
C1J02_RS18515	COG1381	Involved in DNA repair and RecF pathway recombination
C1J02_RS18525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1J02_RS18530	COG0571	ribonuclease III activity
C1J02_RS18535	COG0681	Belongs to the peptidase S26 family
C1J02_RS18540	COG0736	holo-[acyl-carrier-protein] synthase activity
C1J02_RS18550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1J02_RS18560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1J02_RS18565	COG1758	RNA polymerase activity
C1J02_RS18570	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1J02_RS18580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1J02_RS18595	COG0328	RNA-DNA hybrid ribonuclease activity
C1J02_RS18600	COG2860	membrane
C1J02_RS18610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1J02_RS18615	COG0242	peptide deformylase activity
C1J02_RS18620	COG0242	peptide deformylase activity
C1J02_RS18625	COG0242	peptide deformylase activity
C1J02_RS18630	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1J02_RS18640	COG0435	Glutathione S-transferase
C1J02_RS18655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C1J02_RS18690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1J02_RS18695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1J02_RS18700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1J02_RS18705	COG0356	it plays a direct role in the translocation of protons across the membrane
C1J02_RS18715	COG0583	DNA-binding transcription factor activity
C1J02_RS18725	COG0640	Transcriptional regulator
C1J02_RS18740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1J02_RS18750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1J02_RS18775	COG0228	four-way junction DNA binding
C1J02_RS18780	COG0778	Nitroreductase
C1J02_RS18785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1J02_RS18795	COG0336	Belongs to the RNA methyltransferase TrmD family
C1J02_RS18805	COG2326	polyphosphate kinase activity
C1J02_RS18810	COG0335	large ribosomal subunit rRNA binding
C1J02_RS18815	COG0254	rRNA binding
C1J02_RS18820	COG0489	protein tyrosine kinase activity
C1J02_RS18820	COG2151	metal-sulfur cluster biosynthetic enzyme
C1J02_RS18840	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1J02_RS18850	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1J02_RS18870	COG0747	negative chemotaxis
C1J02_RS18880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1J02_RS18915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1J02_RS18950	COG1024	Enoyl-CoA hydratase
C1J02_RS18975	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS18985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1J02_RS18995	COG1686	Belongs to the peptidase S11 family
C1J02_RS19000	COG0583	DNA-binding transcription factor activity
C1J02_RS19005	COG1335	isochorismatase
C1J02_RS19010	COG4172	Belongs to the ABC transporter superfamily
C1J02_RS19015	COG4239	(ABC) transporter, permease
C1J02_RS19020	COG4174	ABC transporter (Permease)
C1J02_RS19025	COG4166	transmembrane transport
C1J02_RS19035	COG0077	Prephenate dehydratase
C1J02_RS19050	COG2816	NAD+ diphosphatase activity
C1J02_RS19055	COG0737	Belongs to the 5'-nucleotidase family
C1J02_RS19065	COG2321	neutral zinc metallopeptidase
C1J02_RS19075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1J02_RS19080	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1J02_RS19085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1J02_RS19120	COG0183	Belongs to the thiolase family
C1J02_RS19125	COG1268	BioY protein
C1J02_RS19130	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C1J02_RS19135	COG1122	ATPase activity
C1J02_RS19145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1J02_RS19150	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C1J02_RS19155	COG1522	sequence-specific DNA binding
C1J02_RS19160	COG0686	Belongs to the AlaDH PNT family
C1J02_RS19175	COG1970	mechanosensitive ion channel activity
C1J02_RS19180	COG0625	glutathione transferase activity
C1J02_RS19185	COG1917	Cupin 2, conserved barrel domain protein
C1J02_RS19200	COG0072	phenylalanine-tRNA ligase activity
C1J02_RS19200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1J02_RS19215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1J02_RS19220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1J02_RS19225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1J02_RS19230	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1J02_RS19230	COG2755	lipolytic protein G-D-S-L family
C1J02_RS19245	COG0469	pyruvate kinase activity
C1J02_RS19275	COG4948	Mandelate Racemase Muconate Lactonizing
C1J02_RS19300	COG0825	malonyl-CoA metabolic process
C1J02_RS19340	COG0513	Belongs to the DEAD box helicase family
C1J02_RS19345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J02_RS19350	COG1116	anion transmembrane transporter activity
C1J02_RS19360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J02_RS19370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1J02_RS19375	COG0028	Belongs to the TPP enzyme family
C1J02_RS19385	COG0243	molybdopterin cofactor binding
C1J02_RS19390	COG0437	4 iron, 4 sulfur cluster binding
C1J02_RS19400	COG1473	amidohydrolase
C1J02_RS19405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1J02_RS19410	COG0741	lytic transglycosylase activity
C1J02_RS19415	COG0697	spore germination
C1J02_RS19420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J02_RS19420	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C1J02_RS19435	COG2885	chlorophyll binding
C1J02_RS19440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1J02_RS19440	COG2169	Transcriptional regulator
C1J02_RS19445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1J02_RS19450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1J02_RS19465	COG1051	belongs to the nudix hydrolase family
C1J02_RS19470	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J02_RS19470	COG1902	pentaerythritol trinitrate reductase activity
C1J02_RS19480	COG0583	DNA-binding transcription factor activity
C1J02_RS19500	COG1058	Belongs to the CinA family
C1J02_RS19500	COG1546	Belongs to the CinA family
C1J02_RS19505	COG1489	DNA binding
C1J02_RS19510	COG0024	Methionine aminopeptidase
C1J02_RS19515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1J02_RS19520	COG0742	ribosomal rna small subunit methyltransferase
C1J02_RS19530	COG0678	peroxiredoxin activity
C1J02_RS19535	COG0668	transmembrane transport
C1J02_RS19540	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1J02_RS19560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1J02_RS19585	COG0004	ammonium transporteR
C1J02_RS19595	COG2897	thiosulfate sulfurtransferase activity
C1J02_RS19610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1J02_RS19685	COG1012	belongs to the aldehyde dehydrogenase family
C1J02_RS19700	COG2304	oxidoreductase activity
C1J02_RS19715	COG0587	DNA-directed DNA polymerase activity
C1J02_RS19720	COG0709	Synthesizes selenophosphate from selenide and ATP
C1J02_RS19725	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C1J02_RS19745	COG0247	lactate metabolic process
C1J02_RS19750	COG0277	FAD linked oxidase domain protein
C1J02_RS19755	COG0277	FAD linked oxidase domain protein
C1J02_RS19770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1J02_RS19775	COG0799	negative regulation of ribosome biogenesis
C1J02_RS19785	COG3264	Mechanosensitive ion channel
C1J02_RS19785	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1J02_RS19790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1J02_RS19795	COG0066	3-isopropylmalate dehydratase activity
C1J02_RS19810	COG0473	3-isopropylmalate dehydrogenase activity
C1J02_RS19815	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1J02_RS19845	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J02_RS19850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J02_RS19880	COG1414	Transcriptional regulator
C1J02_RS19885	COG3214	Protein conserved in bacteria
C1J02_RS19890	COG1609	Transcriptional regulator
C1J02_RS19910	COG0543	2 iron, 2 sulfur cluster binding
C1J02_RS19910	COG0633	Ferredoxin
C1J02_RS19935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1J02_RS19940	COG0022	dehydrogenase e1 component
C1J02_RS19940	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J02_RS19970	COG2989	Protein conserved in bacteria
C1J02_RS19975	COG1393	Belongs to the ArsC family
C1J02_RS19985	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
C1J02_RS19990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1J02_RS19995	COG1132	(ABC) transporter
C1J02_RS20050	COG1028	Short-chain dehydrogenase reductase Sdr
C1J02_RS20055	COG0129	dihydroxy-acid dehydratase activity
C1J02_RS20085	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C1J02_RS20095	COG4533	DNA binding
C1J02_RS20105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J02_RS20110	COG0444	Belongs to the ABC transporter superfamily
C1J02_RS20135	COG0436	Aminotransferase
C1J02_RS20160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1J02_RS20170	COG1070	Carbohydrate kinase
C1J02_RS20185	COG0747	negative chemotaxis
C1J02_RS20190	COG0601	transmembrane transport
C1J02_RS20195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J02_RS20200	COG0444	Belongs to the ABC transporter superfamily
C1J02_RS20205	COG4608	Belongs to the ABC transporter superfamily
C1J02_RS20210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1J02_RS20220	COG0402	S-adenosylhomocysteine deaminase activity
C1J02_RS20225	COG0402	S-adenosylhomocysteine deaminase activity
C1J02_RS20240	COG2351	hydroxyisourate hydrolase activity
C1J02_RS20245	COG2351	hydroxyisourate hydrolase activity
C1J02_RS20260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS20280	COG1802	Transcriptional regulator
C1J02_RS20310	COG0154	amidase activity
C1J02_RS20320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J02_RS20320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J02_RS20330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J02_RS20335	COG1802	Transcriptional regulator
C1J02_RS20355	COG4191	Histidine kinase
C1J02_RS20365	COG1414	Transcriptional regulator
C1J02_RS20370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1J02_RS20375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1J02_RS20380	COG3616	Alanine racemase, N-terminal domain
C1J02_RS20385	COG2423	ornithine cyclodeaminase activity
C1J02_RS20395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1J02_RS20400	COG0281	malic enzyme
C1J02_RS20400	COG0280	phosphate acetyltransferase
C1J02_RS20420	COG0583	DNA-binding transcription factor activity
C1J02_RS20425	COG0251	oxidation-reduction process
C1J02_RS20475	COG4227	nucleotidyltransferase activity
C1J02_RS20500	COG2207	Transcriptional regulator
C1J02_RS20510	COG1573	uracil-dna glycosylase
C1J02_RS20525	COG2171	N-acyltransferase activity
C1J02_RS20540	COG0583	DNA-binding transcription factor activity
C1J02_RS20550	COG0747	negative chemotaxis
C1J02_RS20555	COG0601	transmembrane transport
C1J02_RS20560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J02_RS20565	COG0444	Belongs to the ABC transporter superfamily
C1J02_RS20580	COG0318	PFAM AMP-dependent synthetase and ligase
C1J02_RS20605	COG2358	TRAP transporter, solute receptor (TAXI family
C1J02_RS20615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1J02_RS20645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1J02_RS20670	COG0640	Transcriptional regulator
C1J02_RS20675	COG3830	Belongs to the UPF0237 family
C1J02_RS20675	COG0560	Phosphoserine phosphatase
C1J02_RS20685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1J02_RS20690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1J02_RS20700	COG1063	alcohol dehydrogenase
C1J02_RS20705	COG0156	8-amino-7-oxononanoate synthase activity
C1J02_RS20710	COG0183	Belongs to the thiolase family
C1J02_RS20720	COG2226	methyltransferase
C1J02_RS20730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1J02_RS20735	COG1024	Enoyl-CoA hydratase
C1J02_RS20740	COG0268	Binds directly to 16S ribosomal RNA