locus-tag	class	description
C1J04_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1J04_RS00050	COG3328	transposase activity
C1J04_RS00145	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C1J04_RS00150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1J04_RS00165	COG0284	orotidine-5'-phosphate decarboxylase activity
C1J04_RS00170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1J04_RS00185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1J04_RS00190	COG0625	glutathione transferase activity
C1J04_RS00195	COG1840	ABC-type Fe3 transport system, periplasmic component
C1J04_RS00200	COG1178	ABC-type Fe3 transport system permease component
C1J04_RS00205	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C1J04_RS00225	COG0559	Belongs to the binding-protein-dependent transport system permease family
C1J04_RS00265	COG3383	formate dehydrogenase (NAD+) activity
C1J04_RS00275	COG0625	glutathione transferase activity
C1J04_RS00330	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C1J04_RS00335	COG3257	ureidoglycine aminohydrolase activity
C1J04_RS00345	COG2351	hydroxyisourate hydrolase activity
C1J04_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
C1J04_RS00360	COG0612	Peptidase, M16
C1J04_RS00365	COG0612	Peptidase, M16
C1J04_RS00380	COG0138	bifunctional purine biosynthesis protein purh
C1J04_RS00390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1J04_RS00390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1J04_RS00405	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1J04_RS00410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1J04_RS00415	COG3698	Phosphodiester glycosidase
C1J04_RS00420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1J04_RS00435	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1J04_RS00445	COG1185	polyribonucleotide nucleotidyltransferase activity
C1J04_RS00475	COG0489	protein tyrosine kinase activity
C1J04_RS00510	COG0243	molybdopterin cofactor binding
C1J04_RS00510	COG3383	formate dehydrogenase (NAD+) activity
C1J04_RS00515	COG0437	4 iron, 4 sulfur cluster binding
C1J04_RS00530	COG3842	ATPase activity
C1J04_RS00545	COG0450	alkyl hydroperoxide reductase
C1J04_RS00555	COG0564	pseudouridine synthase activity
C1J04_RS00580	COG0183	Belongs to the thiolase family
C1J04_RS00585	COG1366	Belongs to the anti-sigma-factor antagonist family
C1J04_RS00595	COG0405	Gamma-glutamyltransferase
C1J04_RS00620	COG1674	ftsk spoiiie
C1J04_RS00625	COG0436	Aminotransferase
C1J04_RS00630	COG0154	amidase activity
C1J04_RS00635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1J04_RS00640	COG2835	tetraacyldisaccharide 4'-kinase activity
C1J04_RS00655	COG0708	Exodeoxyribonuclease III
C1J04_RS00660	COG0745	RESPONSE REGULATOR receiver
C1J04_RS00675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1J04_RS00690	COG0495	leucyl-tRNA aminoacylation
C1J04_RS00730	COG0312	modulator of DNA gyrase
C1J04_RS00745	COG1519	Transferase
C1J04_RS00750	COG1663	tetraacyldisaccharide 4'-kinase activity
C1J04_RS00770	COG1194	a g-specific adenine glycosylase
C1J04_RS00785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1J04_RS00805	COG1609	Transcriptional regulator
C1J04_RS00810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J04_RS00825	COG0129	dihydroxy-acid dehydratase activity
C1J04_RS00830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1J04_RS00845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1J04_RS00855	COG0288	reversible hydration of carbon dioxide
C1J04_RS00865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1J04_RS00870	COG0791	NLP P60 protein
C1J04_RS00880	COG2050	protein possibly involved in aromatic compounds catabolism
C1J04_RS00895	COG0679	Auxin Efflux Carrier
C1J04_RS00900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C1J04_RS00905	COG1671	Belongs to the UPF0178 family
C1J04_RS00915	COG2423	ornithine cyclodeaminase activity
C1J04_RS00920	COG0596	Alpha beta hydrolase
C1J04_RS00930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1J04_RS00940	COG0285	dihydrofolate synthase activity
C1J04_RS00945	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1J04_RS00955	COG2274	protein secretion by the type I secretion system
C1J04_RS00960	COG0129	dihydroxy-acid dehydratase activity
C1J04_RS00980	COG0569	domain protein
C1J04_RS00985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1J04_RS00990	COG0793	Belongs to the peptidase S41A family
C1J04_RS01000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1J04_RS01015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1J04_RS01015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1J04_RS01020	COG3622	Belongs to the hyi family
C1J04_RS01030	COG0714	Associated with various cellular activities
C1J04_RS01050	COG5002	protein histidine kinase activity
C1J04_RS01050	COG2205	protein histidine kinase activity
C1J04_RS01050	COG0784	Response regulator, receiver
C1J04_RS01055	COG3022	response to hydroperoxide
C1J04_RS01060	COG0514	ATP-dependent DNA helicase (RecQ)
C1J04_RS01080	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C1J04_RS01090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1J04_RS01105	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C1J04_RS01110	COG2095	MarC family integral membrane protein
C1J04_RS01115	COG1335	isochorismatase
C1J04_RS01120	COG1054	Belongs to the UPF0176 family
C1J04_RS01125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1J04_RS01130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J04_RS01135	COG1177	transmembrane transport
C1J04_RS01140	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J04_RS01145	COG3842	ATPase activity
C1J04_RS01155	COG1802	Transcriptional regulator
C1J04_RS01165	COG3842	ATPase activity
C1J04_RS01185	COG2951	lytic endotransglycosylase activity
C1J04_RS01190	COG0557	exoribonuclease II activity
C1J04_RS01205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J04_RS01220	COG2171	N-acyltransferase activity
C1J04_RS01235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1J04_RS01250	COG0560	Phosphoserine phosphatase
C1J04_RS01255	COG0183	Belongs to the thiolase family
C1J04_RS01260	COG3396	Phenylacetate-CoA oxygenase
C1J04_RS01265	COG3460	Phenylacetate-CoA oxygenase
C1J04_RS01270	COG3396	Phenylacetate-CoA oxygenase
C1J04_RS01275	COG2151	metal-sulfur cluster biosynthetic enzyme
C1J04_RS01280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1J04_RS01285	COG2030	dehydratase
C1J04_RS01285	COG1012	belongs to the aldehyde dehydrogenase family
C1J04_RS01300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1J04_RS01300	COG0517	IMP dehydrogenase activity
C1J04_RS01315	COG1137	ATPase activity
C1J04_RS01320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1J04_RS01325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1J04_RS01350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1J04_RS01360	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1J04_RS01380	COG0443	Heat shock 70 kDa protein
C1J04_RS01385	COG0484	heat shock protein binding
C1J04_RS01390	COG2003	Belongs to the UPF0758 family
C1J04_RS01410	COG3206	protein involved in exopolysaccharide biosynthesis
C1J04_RS01410	COG0489	protein tyrosine kinase activity
C1J04_RS01420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1J04_RS01420	COG3008	intermembrane lipid transfer
C1J04_RS01425	COG2995	paraquat-inducible protein a
C1J04_RS01435	COG0693	protein deglycase activity
C1J04_RS01470	COG0069	glutamate synthase activity
C1J04_RS01475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1J04_RS01480	COG1396	sequence-specific DNA binding
C1J04_RS01500	COG0784	Response regulator, receiver
C1J04_RS01525	COG1295	ribonuclease BN
C1J04_RS01530	COG2116	formate transmembrane transporter activity
C1J04_RS01540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J04_RS01545	COG0443	Heat shock 70 kDa protein
C1J04_RS01550	COG0747	negative chemotaxis
C1J04_RS01585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1J04_RS01605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J04_RS01615	COG3191	aminopeptidase activity
C1J04_RS01620	COG3474	cytochrome
C1J04_RS01650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1J04_RS01655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1J04_RS01660	COG2350	Protein conserved in bacteria
C1J04_RS01675	COG1858	cytochrome C peroxidase
C1J04_RS01685	COG1940	carbohydrate kinase activity
C1J04_RS01690	COG4213	ABC transporter substrate-binding protein
C1J04_RS01695	COG4214	carbohydrate transport
C1J04_RS01700	COG1129	ABC transporter
C1J04_RS01705	COG1070	Carbohydrate kinase
C1J04_RS01710	COG2115	Belongs to the xylose isomerase family
C1J04_RS01720	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1J04_RS01730	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1J04_RS01740	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C1J04_RS01745	COG1999	signal sequence binding
C1J04_RS01755	COG2205	protein histidine kinase activity
C1J04_RS01760	COG0802	atpase or kinase
C1J04_RS01765	COG3178	'Phosphotransferase
C1J04_RS01770	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1J04_RS01780	COG1074	ATP-dependent DNA helicase activity
C1J04_RS01795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C1J04_RS01800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1J04_RS01830	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C1J04_RS01835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1J04_RS01840	COG0237	dephospho-CoA kinase activity
C1J04_RS01845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1J04_RS01850	COG0424	maF-like protein
C1J04_RS01855	COG1981	membrane
C1J04_RS01860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1J04_RS01865	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1J04_RS01870	COG0445	tRNA wobble uridine modification
C1J04_RS01875	COG0357	Ribosomal RNA small subunit methyltransferase G
C1J04_RS01890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1J04_RS01895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1J04_RS01900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1J04_RS01910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1J04_RS01915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1J04_RS01920	COG0281	malic enzyme
C1J04_RS01920	COG0280	phosphate acetyltransferase
C1J04_RS01930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1J04_RS01935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1J04_RS01950	COG0137	argininosuccinate synthase activity
C1J04_RS01955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1J04_RS01980	COG0494	nUDIX hydrolase
C1J04_RS01985	COG0617	tRNA 3'-terminal CCA addition
C1J04_RS01990	COG1132	(ABC) transporter
C1J04_RS01995	COG1132	(ABC) transporter
C1J04_RS02000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1J04_RS02010	COG3034	peptidoglycan biosynthetic process
C1J04_RS02050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1J04_RS02060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1J04_RS02075	COG0779	Required for maturation of 30S ribosomal subunits
C1J04_RS02090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1J04_RS02100	COG1597	lipid kinase activity
C1J04_RS02100	COG1803	Methylglyoxal synthase
C1J04_RS02105	COG0494	nUDIX hydrolase
C1J04_RS02110	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1J04_RS02115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1J04_RS02120	COG0653	protein targeting
C1J04_RS02135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1J04_RS02140	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1J04_RS02155	COG0463	Glycosyl transferase, family 2
C1J04_RS02180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J04_RS02235	COG0110	maltose O-acetyltransferase activity
C1J04_RS02245	COG0709	Synthesizes selenophosphate from selenide and ATP
C1J04_RS02255	COG4717	serine-type aminopeptidase activity
C1J04_RS02305	COG1968	undecaprenyl-diphosphatase activity
C1J04_RS02325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1J04_RS02335	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1J04_RS02345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1J04_RS02355	COG0697	spore germination
C1J04_RS02365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1J04_RS02370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C1J04_RS02375	COG0438	transferase activity, transferring glycosyl groups
C1J04_RS02390	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1J04_RS02395	COG1178	ABC-type Fe3 transport system permease component
C1J04_RS02400	COG4143	(ABC) transporter
C1J04_RS02405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1J04_RS02420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1J04_RS02425	COG1846	Transcriptional regulator
C1J04_RS02430	COG0745	RESPONSE REGULATOR receiver
C1J04_RS02435	COG1722	exodeoxyribonuclease VII activity
C1J04_RS02440	COG0142	geranyltranstransferase activity
C1J04_RS02445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1J04_RS02455	COG2808	Putative FMN-binding domain
C1J04_RS02460	COG0625	glutathione transferase activity
C1J04_RS02485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1J04_RS02490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1J04_RS02500	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1J04_RS02510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C1J04_RS02525	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J04_RS02530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J04_RS02535	COG3214	Protein conserved in bacteria
C1J04_RS02540	COG1609	Transcriptional regulator
C1J04_RS02560	COG3707	response regulator
C1J04_RS02565	COG1116	anion transmembrane transporter activity
C1J04_RS02565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1J04_RS02570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1J04_RS02575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J04_RS02580	COG1116	anion transmembrane transporter activity
C1J04_RS02580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1J04_RS02585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1J04_RS02590	COG2146	nitrite reductase [NAD(P)H] activity
C1J04_RS02595	COG0243	molybdopterin cofactor binding
C1J04_RS02600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1J04_RS02605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1J04_RS02605	COG1648	precorrin-2 dehydrogenase activity
C1J04_RS02615	COG4774	siderophore transport
C1J04_RS02620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1J04_RS02625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1J04_RS02630	COG1120	ATPase activity
C1J04_RS02635	COG1132	(ABC) transporter
C1J04_RS02640	COG0642	Histidine kinase
C1J04_RS02645	COG0745	RESPONSE REGULATOR receiver
C1J04_RS02655	COG2194	sulfuric ester hydrolase activity
C1J04_RS02665	COG0473	3-isopropylmalate dehydrogenase activity
C1J04_RS02680	COG0066	3-isopropylmalate dehydratase activity
C1J04_RS02685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1J04_RS02695	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1J04_RS02695	COG3264	Mechanosensitive ion channel
C1J04_RS02700	COG0799	negative regulation of ribosome biogenesis
C1J04_RS02705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1J04_RS02720	COG0277	FAD linked oxidase domain protein
C1J04_RS02725	COG0277	FAD linked oxidase domain protein
C1J04_RS02735	COG0247	lactate metabolic process
C1J04_RS02750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1J04_RS02755	COG1012	belongs to the aldehyde dehydrogenase family
C1J04_RS02800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1J04_RS02805	COG2897	thiosulfate sulfurtransferase activity
C1J04_RS02815	COG0004	ammonium transporteR
C1J04_RS02820	COG0347	Belongs to the P(II) protein family
C1J04_RS02835	COG0583	DNA-binding transcription factor activity
C1J04_RS02840	COG2853	Lipoprotein
C1J04_RS02850	COG0584	glycerophosphoryl diester phosphodiesterase
C1J04_RS02860	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1J04_RS02865	COG0678	peroxiredoxin activity
C1J04_RS02875	COG0742	ribosomal rna small subunit methyltransferase
C1J04_RS02885	COG1183	phosphatidylcholine synthase activity
C1J04_RS02890	COG0024	Methionine aminopeptidase
C1J04_RS02895	COG1489	DNA binding
C1J04_RS02900	COG1058	Belongs to the CinA family
C1J04_RS02900	COG1546	Belongs to the CinA family
C1J04_RS02920	COG0583	DNA-binding transcription factor activity
C1J04_RS02930	COG1902	pentaerythritol trinitrate reductase activity
C1J04_RS02930	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J04_RS02935	COG1051	belongs to the nudix hydrolase family
C1J04_RS02950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1J04_RS02955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1J04_RS02960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1J04_RS02975	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C1J04_RS02975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J04_RS02980	COG0697	spore germination
C1J04_RS02985	COG0741	lytic transglycosylase activity
C1J04_RS02990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1J04_RS03000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J04_RS03020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1J04_RS03025	COG0830	nickel cation binding
C1J04_RS03030	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C1J04_RS03035	COG0804	urea catabolic process
C1J04_RS03040	COG0832	Belongs to the urease beta subunit family
C1J04_RS03050	COG0831	urea catabolic process
C1J04_RS03055	COG0829	nickel cation binding
C1J04_RS03075	COG1917	Cupin 2, conserved barrel domain protein
C1J04_RS03075	COG2207	Transcriptional regulator
C1J04_RS03090	COG1309	transcriptional regulator
C1J04_RS03120	COG0825	malonyl-CoA metabolic process
C1J04_RS03130	COG2301	Belongs to the HpcH HpaI aldolase family
C1J04_RS03140	COG4948	Mandelate Racemase Muconate Lactonizing
C1J04_RS03155	COG0469	pyruvate kinase activity
C1J04_RS03165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1J04_RS03170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1J04_RS03180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1J04_RS03195	COG0072	phenylalanine-tRNA ligase activity
C1J04_RS03195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1J04_RS03205	COG1970	mechanosensitive ion channel activity
C1J04_RS03210	COG0686	Belongs to the AlaDH PNT family
C1J04_RS03215	COG1522	sequence-specific DNA binding
C1J04_RS03225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1J04_RS03235	COG1122	ATPase activity
C1J04_RS03240	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C1J04_RS03260	COG2197	response regulator
C1J04_RS03280	COG0019	diaminopimelate decarboxylase activity
C1J04_RS03285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1J04_RS03300	COG0745	RESPONSE REGULATOR receiver
C1J04_RS03305	COG0346	lactoylglutathione lyase activity
C1J04_RS03320	COG0778	Nitroreductase
C1J04_RS03330	COG0180	Tryptophanyl-tRNA synthetase
C1J04_RS03340	COG0728	peptidoglycan biosynthetic process
C1J04_RS03345	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1J04_RS03355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1J04_RS03365	COG0189	ligase activity
C1J04_RS03375	COG0606	chelatase, subunit chli
C1J04_RS03390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1J04_RS03400	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C1J04_RS03405	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C1J04_RS03410	COG3639	organic phosphonate transmembrane transporter activity
C1J04_RS03415	COG3639	organic phosphonate transmembrane transporter activity
C1J04_RS03425	COG2188	Transcriptional regulator
C1J04_RS03430	COG3624	Phosphonate C-P lyase system protein PhnG
C1J04_RS03435	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C1J04_RS03440	COG3626	phosphonate metabolism
C1J04_RS03445	COG3627	carbon phosphorus lyase activity
C1J04_RS03450	COG4107	phosphonate C-P lyase system protein PhnK
C1J04_RS03455	COG4778	phosphonate C-P lyase system protein PhnL
C1J04_RS03465	COG3454	Phosphonate metabolism
C1J04_RS03470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1J04_RS03475	COG0339	signal peptide processing
C1J04_RS03480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1J04_RS03485	COG0772	Belongs to the SEDS family
C1J04_RS03490	COG0768	penicillin binding
C1J04_RS03520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1J04_RS03530	COG3046	protein related to deoxyribodipyrimidine photolyase
C1J04_RS03545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1J04_RS03560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J04_RS03565	COG0509	glycine decarboxylation via glycine cleavage system
C1J04_RS03570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1J04_RS03570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1J04_RS03580	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C1J04_RS03585	COG4181	ATPase activity
C1J04_RS03595	COG1278	Cold shock
C1J04_RS03600	COG0493	'glutamate synthase
C1J04_RS03610	COG1309	transcriptional regulator
C1J04_RS03635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J04_RS03640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J04_RS03645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1J04_RS03650	COG1376	ErfK ybiS ycfS ynhG family protein
C1J04_RS03655	COG1278	Cold shock
C1J04_RS03665	COG0488	(ABC) transporter
C1J04_RS03675	COG1115	amino acid carrier protein
C1J04_RS03680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1J04_RS03690	COG2027	D-alanyl-D-alanine carboxypeptidase
C1J04_RS03700	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C1J04_RS03740	COG0556	nucleotide-excision repair
C1J04_RS03760	COG1921	L-seryl-tRNASec selenium transferase activity
C1J04_RS03790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1J04_RS03795	COG2971	BadF BadG BcrA BcrD
C1J04_RS03800	COG0129	dihydroxy-acid dehydratase activity
C1J04_RS03805	COG0800	Aldolase
C1J04_RS03825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1J04_RS03830	COG0165	Argininosuccinate lyase
C1J04_RS03845	COG0019	diaminopimelate decarboxylase activity
C1J04_RS03860	COG2884	Cell division ATP-binding protein ftsE
C1J04_RS03890	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J04_RS03915	COG0045	succinate-CoA ligase (ADP-forming) activity
C1J04_RS03920	COG2030	dehydratase
C1J04_RS03935	COG2301	Belongs to the HpcH HpaI aldolase family
C1J04_RS03945	COG0039	L-malate dehydrogenase activity
C1J04_RS03990	COG0813	purine-nucleoside phosphorylase activity
C1J04_RS04000	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J04_RS04000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J04_RS04005	COG2937	Belongs to the GPAT DAPAT family
C1J04_RS04010	COG0604	alcohol dehydrogenase
C1J04_RS04015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1J04_RS04025	COG0730	response to heat
C1J04_RS04030	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1J04_RS04035	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1J04_RS04040	COG3845	ABC transporter
C1J04_RS04045	COG1744	ABC transporter substrate-binding protein PnrA-like
C1J04_RS04050	COG0456	acetyltransferase
C1J04_RS04055	COG1214	PFAM Peptidase M22, glycoprotease
C1J04_RS04060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1J04_RS04090	COG1272	protein, Hemolysin III
C1J04_RS04100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1J04_RS04110	COG0133	tryptophan synthase activity
C1J04_RS04135	COG0193	aminoacyl-tRNA hydrolase activity
C1J04_RS04140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1J04_RS04150	COG0159	tryptophan synthase activity
C1J04_RS04160	COG0012	GTP binding
C1J04_RS04170	COG4221	oxidoreductase activity
C1J04_RS04175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1J04_RS04195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1J04_RS04205	COG1643	Atp-dependent helicase
C1J04_RS04210	COG1703	isobutyryl-CoA mutase activity
C1J04_RS04225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1J04_RS04260	COG0632	four-way junction helicase activity
C1J04_RS04265	COG2255	four-way junction helicase activity
C1J04_RS04275	COG0824	Thioesterase
C1J04_RS04300	COG0823	Involved in the tonB-independent uptake of proteins
C1J04_RS04305	COG2885	chlorophyll binding
C1J04_RS04315	COG0037	tRNA processing
C1J04_RS04320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1J04_RS04330	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1J04_RS04335	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1J04_RS04350	COG1201	RNA secondary structure unwinding
C1J04_RS04400	COG4964	Belongs to the GSP D family
C1J04_RS04420	COG0741	lytic transglycosylase activity
C1J04_RS04425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C1J04_RS04440	COG1754	DNA topoisomerase type I activity
C1J04_RS04440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1J04_RS04445	COG0758	DNA mediated transformation
C1J04_RS04450	COG0312	modulator of DNA gyrase
C1J04_RS04460	COG0109	protoheme IX farnesyltransferase activity
C1J04_RS04470	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C1J04_RS04480	COG3346	SURF1 family
C1J04_RS04490	COG0612	Peptidase, M16
C1J04_RS04510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1J04_RS04515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1J04_RS04525	COG0306	phosphate transporter
C1J04_RS04535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1J04_RS04540	COG0101	tRNA pseudouridine synthase activity
C1J04_RS04545	COG3106	COG3106 Predicted ATPase
C1J04_RS04555	COG3768	UPF0283 membrane protein
C1J04_RS04560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1J04_RS04570	COG1183	phosphatidylcholine synthase activity
C1J04_RS04575	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1J04_RS04590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1J04_RS04595	COG0583	DNA-binding transcription factor activity
C1J04_RS04600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1J04_RS04605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1J04_RS04610	COG0424	maF-like protein
C1J04_RS04620	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C1J04_RS04640	COG0702	epimerase
C1J04_RS04660	COG0583	DNA-binding transcription factor activity
C1J04_RS04665	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C1J04_RS04675	COG1053	succinate dehydrogenase
C1J04_RS04675	COG3976	FMN-binding domain protein
C1J04_RS04680	COG1802	Transcriptional regulator
C1J04_RS04700	COG2828	Protein conserved in bacteria
C1J04_RS04720	COG2205	protein histidine kinase activity
C1J04_RS04735	COG3321	synthase
C1J04_RS04735	COG0604	alcohol dehydrogenase
C1J04_RS04735	COG4221	oxidoreductase activity
C1J04_RS04735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1J04_RS04740	COG1024	Enoyl-CoA hydratase
C1J04_RS04745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1J04_RS04750	COG0022	dehydrogenase e1 component
C1J04_RS04760	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J04_RS04765	COG0095	Lipoate-protein ligase
C1J04_RS04775	COG2204	response regulator
C1J04_RS04800	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C1J04_RS04825	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1J04_RS04840	COG5002	protein histidine kinase activity
C1J04_RS04840	COG2205	protein histidine kinase activity
C1J04_RS04840	COG0784	Response regulator, receiver
C1J04_RS04850	COG2323	membrane
C1J04_RS04865	COG0848	biopolymer transport protein
C1J04_RS04875	COG3128	pkhd-type hydroxylase
C1J04_RS04880	COG4774	siderophore transport
C1J04_RS04895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1J04_RS04905	COG0778	Nitroreductase
C1J04_RS04925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1J04_RS04935	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1J04_RS04940	COG5328	Belongs to the UPF0262 family
C1J04_RS04960	COG0481	GTPase activity
C1J04_RS04975	COG0588	phosphoglycerate mutase activity
C1J04_RS04980	COG0438	transferase activity, transferring glycosyl groups
C1J04_RS04995	COG0668	transmembrane transport
C1J04_RS05000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1J04_RS05005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J04_RS05010	COG0601	transmembrane transport
C1J04_RS05015	COG0747	negative chemotaxis
C1J04_RS05020	COG4172	Belongs to the ABC transporter superfamily
C1J04_RS05050	COG1024	Enoyl-CoA hydratase
C1J04_RS05050	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J04_RS05055	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS05060	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS05070	COG1024	Enoyl-CoA hydratase
C1J04_RS05075	COG0318	PFAM AMP-dependent synthetase and ligase
C1J04_RS05095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J04_RS05120	COG0785	Cytochrome C biogenesis protein
C1J04_RS05145	COG3258	Cytochrome c
C1J04_RS05150	COG0737	Belongs to the 5'-nucleotidase family
C1J04_RS05180	COG0318	PFAM AMP-dependent synthetase and ligase
C1J04_RS05185	COG0028	Belongs to the TPP enzyme family
C1J04_RS05190	COG0668	transmembrane transport
C1J04_RS05200	COG2943	transferase activity, transferring hexosyl groups
C1J04_RS05205	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C1J04_RS05210	COG1757	Na H antiporter
C1J04_RS05220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J04_RS05225	COG3608	succinylglutamate desuccinylase aspartoacylase
C1J04_RS05230	COG0006	proline dipeptidase activity
C1J04_RS05235	COG1522	sequence-specific DNA binding
C1J04_RS05245	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C1J04_RS05250	COG2202	Pas domain
C1J04_RS05250	COG3920	Histidine kinase
C1J04_RS05255	COG0784	Response regulator, receiver
C1J04_RS05255	COG4191	Histidine kinase
C1J04_RS05285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1J04_RS05290	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C1J04_RS05295	COG2080	2 iron, 2 sulfur cluster binding
C1J04_RS05300	COG0583	DNA-binding transcription factor activity
C1J04_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS05325	COG0402	S-adenosylhomocysteine deaminase activity
C1J04_RS05340	COG1116	anion transmembrane transporter activity
C1J04_RS05350	COG0405	Gamma-glutamyltransferase
C1J04_RS05355	COG4608	Belongs to the ABC transporter superfamily
C1J04_RS05360	COG0444	Belongs to the ABC transporter superfamily
C1J04_RS05365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J04_RS05370	COG0601	transmembrane transport
C1J04_RS05375	COG0747	negative chemotaxis
C1J04_RS05380	COG1802	Transcriptional regulator
C1J04_RS05390	COG4584	PFAM Integrase catalytic
C1J04_RS05435	COG0393	Putative heavy-metal-binding
C1J04_RS05520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1J04_RS05590	COG4373	Mu-like prophage FluMu protein gp28
C1J04_RS05605	COG2369	cell adhesion
C1J04_RS05630	COG4397	Mu-like prophage major head subunit gpT
C1J04_RS05715	COG0604	alcohol dehydrogenase
C1J04_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS05715	COG3321	synthase
C1J04_RS05735	COG0277	FAD linked oxidase domain protein
C1J04_RS05750	COG3757	hydrolase, family 25
C1J04_RS05765	COG0625	glutathione transferase activity
C1J04_RS05785	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1J04_RS05790	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1J04_RS05795	COG3845	ABC transporter
C1J04_RS05805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1J04_RS05820	COG2900	Belongs to the SlyX family
C1J04_RS05825	COG0124	histidyl-tRNA synthetase
C1J04_RS05830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C1J04_RS05835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1J04_RS05850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1J04_RS05875	COG2433	Pfam Transposase IS66
C1J04_RS05890	COG1431	PFAM Stem cell self-renewal protein Piwi
C1J04_RS05915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1J04_RS05920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1J04_RS05970	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS05980	COG4584	PFAM Integrase catalytic
C1J04_RS05990	COG0747	negative chemotaxis
C1J04_RS05995	COG2186	Transcriptional regulator
C1J04_RS06000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1J04_RS06015	COG0191	fructose-bisphosphate aldolase activity
C1J04_RS06025	COG3622	Belongs to the hyi family
C1J04_RS06030	COG0235	Class ii aldolase
C1J04_RS06035	COG3395	kinase activity
C1J04_RS06040	COG2084	Dehydrogenase
C1J04_RS06050	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J04_RS06055	COG1609	Transcriptional regulator
C1J04_RS06075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1J04_RS06100	COG0798	PFAM Bile acid sodium symporter
C1J04_RS06110	COG0431	NADPH-dependent FMN reductase
C1J04_RS06120	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C1J04_RS06150	COG1175	transmembrane transport
C1J04_RS06155	COG0395	ABC-type sugar transport system, permease component
C1J04_RS06165	COG0129	dihydroxy-acid dehydratase activity
C1J04_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS06175	COG3734	2-keto-3-deoxy-galactonokinase
C1J04_RS06180	COG0800	Aldolase
C1J04_RS06195	COG1464	Belongs to the NlpA lipoprotein family
C1J04_RS06200	COG2011	ABC-type metal ion transport system permease component
C1J04_RS06205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1J04_RS06220	COG1522	sequence-specific DNA binding
C1J04_RS06230	COG1448	Aminotransferase
C1J04_RS06245	COG3268	Saccharopine dehydrogenase
C1J04_RS06250	COG1115	amino acid carrier protein
C1J04_RS06255	COG0252	asparaginase activity
C1J04_RS06280	COG3443	Belongs to the bacterial solute-binding protein 9 family
C1J04_RS06285	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J04_RS06300	COG0154	amidase activity
C1J04_RS06315	COG3483	tryptophan 2,3-dioxygenase activity
C1J04_RS06325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1J04_RS06335	COG0583	DNA-binding transcription factor activity
C1J04_RS06365	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C1J04_RS06390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1J04_RS06395	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1J04_RS06410	COG2951	lytic endotransglycosylase activity
C1J04_RS06420	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C1J04_RS06455	COG3246	L-lysine catabolic process to acetate
C1J04_RS06460	COG3485	protocatechuate 3,4-dioxygenase
C1J04_RS06465	COG3485	protocatechuate 3,4-dioxygenase
C1J04_RS06470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1J04_RS06480	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C1J04_RS06485	COG2080	2 iron, 2 sulfur cluster binding
C1J04_RS06490	COG2010	Cytochrome c
C1J04_RS06490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1J04_RS06500	COG0318	PFAM AMP-dependent synthetase and ligase
C1J04_RS06510	COG1132	(ABC) transporter
C1J04_RS06515	COG1652	LysM domain
C1J04_RS06520	COG0318	PFAM AMP-dependent synthetase and ligase
C1J04_RS06525	COG0657	acetylesterase activity
C1J04_RS06535	COG4172	Belongs to the ABC transporter superfamily
C1J04_RS06540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J04_RS06555	COG2936	dipeptidyl-peptidase activity
C1J04_RS06580	COG1490	D-aminoacyl-tRNA deacylase activity
C1J04_RS06625	COG1187	pseudouridine synthase activity
C1J04_RS06630	COG0590	tRNA wobble adenosine to inosine editing
C1J04_RS06645	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1J04_RS06650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1J04_RS06655	COG0154	amidase activity
C1J04_RS06675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1J04_RS06685	COG0670	Belongs to the BI1 family
C1J04_RS06690	COG1396	sequence-specific DNA binding
C1J04_RS06695	COG0483	inositol monophosphate 1-phosphatase activity
C1J04_RS06710	COG0402	S-adenosylhomocysteine deaminase activity
C1J04_RS06715	COG2239	Acts as a magnesium transporter
C1J04_RS06720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1J04_RS06725	COG1692	metallophosphoesterase
C1J04_RS06730	COG0471	metal ion transport
C1J04_RS06730	COG3273	potassium ion transport
C1J04_RS06735	COG3273	potassium ion transport
C1J04_RS06735	COG0471	metal ion transport
C1J04_RS06740	COG0217	transcriptional regulatory protein
C1J04_RS06760	COG1309	transcriptional regulator
C1J04_RS06765	COG3119	arylsulfatase activity
C1J04_RS06790	COG3800	Transcriptional regulator
C1J04_RS06790	COG1396	sequence-specific DNA binding
C1J04_RS06795	COG2814	Major facilitator Superfamily
C1J04_RS06800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1J04_RS06820	COG4770	biotin carboxylase activity
C1J04_RS06835	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J04_RS06835	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1J04_RS06850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1J04_RS06865	COG0248	Ppx GppA phosphatase
C1J04_RS06870	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1J04_RS06880	COG0628	permease
C1J04_RS06890	COG0442	prolyl-tRNA aminoacylation
C1J04_RS06905	COG1136	(ABC) transporter
C1J04_RS06935	COG0187	DNA topoisomerase II activity
C1J04_RS06940	COG0662	Cupin 2, conserved barrel domain protein
C1J04_RS06945	COG0596	Alpha beta hydrolase
C1J04_RS06955	COG0534	Mate efflux family protein
C1J04_RS07010	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C1J04_RS07030	COG1278	Cold shock
C1J04_RS07035	COG1393	Belongs to the ArsC family
C1J04_RS07050	COG3220	belongs to the UPF0276 family
C1J04_RS07060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1J04_RS07100	COG3243	poly(R)-hydroxyalkanoic acid synthase
C1J04_RS07115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1J04_RS07120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J04_RS07125	COG0174	glutamine synthetase
C1J04_RS07130	COG0519	Catalyzes the synthesis of GMP from XMP
C1J04_RS07135	COG0174	glutamine synthetase
C1J04_RS07140	COG0765	amino acid transport
C1J04_RS07145	COG4215	(ABC) transporter
C1J04_RS07175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1J04_RS07180	COG0504	CTP synthase activity
C1J04_RS07205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1J04_RS07240	COG0546	phosphoglycolate phosphatase activity
C1J04_RS07260	COG1215	transferase activity, transferring glycosyl groups
C1J04_RS07270	COG3620	sequence-specific DNA binding
C1J04_RS07275	COG0747	negative chemotaxis
C1J04_RS07285	COG0601	transmembrane transport
C1J04_RS07290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J04_RS07295	COG0444	Belongs to the ABC transporter superfamily
C1J04_RS07300	COG4608	Belongs to the ABC transporter superfamily
C1J04_RS07320	COG4175	Glycine betaine
C1J04_RS07325	COG0697	spore germination
C1J04_RS07330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1J04_RS07335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1J04_RS07345	COG1120	ATPase activity
C1J04_RS07350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1J04_RS07370	COG2207	Transcriptional regulator
C1J04_RS07370	COG3708	Transcriptional regulator
C1J04_RS07385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C1J04_RS07410	COG1760	l-serine dehydratase
C1J04_RS07415	COG0625	glutathione transferase activity
C1J04_RS07420	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C1J04_RS07430	COG0330	HflC and HflK could
C1J04_RS07435	COG0330	HflC and HflK could
C1J04_RS07440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1J04_RS07460	COG1121	(ABC) transporter
C1J04_RS07465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1J04_RS07470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1J04_RS07475	COG0395	ABC-type sugar transport system, permease component
C1J04_RS07485	COG1349	DNA-binding transcription factor activity
C1J04_RS07495	COG3842	ATPase activity
C1J04_RS07500	COG3842	ATPase activity
C1J04_RS07510	COG0395	ABC-type sugar transport system, permease component
C1J04_RS07525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1J04_RS07535	COG1454	alcohol dehydrogenase
C1J04_RS07540	COG0730	response to heat
C1J04_RS07545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1J04_RS07560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1J04_RS07565	COG4235	cytochrome complex assembly
C1J04_RS07570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J04_RS07585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J04_RS07585	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J04_RS07620	COG5265	(ABC) transporter
C1J04_RS07630	COG2814	Major facilitator Superfamily
C1J04_RS07635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1J04_RS07655	COG1160	GTP binding
C1J04_RS07665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1J04_RS07670	COG1862	Preprotein translocase
C1J04_RS07675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1J04_RS07680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1J04_RS07685	COG3737	Protein of unknown function (DUF498/DUF598)
C1J04_RS07690	COG4133	protoheme IX ABC transporter activity
C1J04_RS07695	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1J04_RS07700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1J04_RS07710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1J04_RS07740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1J04_RS07740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1J04_RS07745	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1J04_RS07765	COG0586	Pfam SNARE associated Golgi protein
C1J04_RS07770	COG0598	Magnesium transport protein CorA
C1J04_RS07775	COG0668	transmembrane transport
C1J04_RS07800	COG2205	protein histidine kinase activity
C1J04_RS07815	COG4584	PFAM Integrase catalytic
C1J04_RS07850	COG1234	tRNA 3'-trailer cleavage
C1J04_RS07855	COG0084	hydrolase, TatD family'
C1J04_RS07865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1J04_RS07870	COG1686	Belongs to the peptidase S11 family
C1J04_RS07890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1J04_RS07910	COG2202	Pas domain
C1J04_RS07910	COG2205	protein histidine kinase activity
C1J04_RS07915	COG1349	DNA-binding transcription factor activity
C1J04_RS07930	COG3639	organic phosphonate transmembrane transporter activity
C1J04_RS07940	COG1011	Hydrolase
C1J04_RS07955	COG0811	peptide transport
C1J04_RS07980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1J04_RS07985	COG1121	(ABC) transporter
C1J04_RS08015	COG0740	serine-type endopeptidase activity
C1J04_RS08020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1J04_RS08040	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1J04_RS08045	COG0439	Biotin carboxylase
C1J04_RS08050	COG0511	ligase activity, forming carbon-carbon bonds
C1J04_RS08055	COG0410	ABC transporter
C1J04_RS08080	COG3800	Transcriptional regulator
C1J04_RS08080	COG1396	sequence-specific DNA binding
C1J04_RS08085	COG0745	RESPONSE REGULATOR receiver
C1J04_RS08120	COG3750	Belongs to the UPF0335 family
C1J04_RS08125	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1J04_RS08140	COG0359	binds to the 23S rRNA
C1J04_RS08145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1J04_RS08150	COG0360	Binds together with S18 to 16S ribosomal RNA
C1J04_RS08160	COG2353	YceI-like domain
C1J04_RS08165	COG3038	cytochrome b561
C1J04_RS08170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1J04_RS08180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1J04_RS08190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1J04_RS08195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1J04_RS08210	COG4695	Portal protein
C1J04_RS08290	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J04_RS08295	COG0022	dehydrogenase e1 component
C1J04_RS08295	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1J04_RS08300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1J04_RS08310	COG0126	phosphoglycerate kinase activity
C1J04_RS08330	COG0739	heme binding
C1J04_RS08335	COG2833	Protein of unknown function (DUF455)
C1J04_RS08340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1J04_RS08350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1J04_RS08355	COG2814	Major facilitator Superfamily
C1J04_RS08365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1J04_RS08370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1J04_RS08410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1J04_RS08425	COG2354	Protein conserved in bacteria
C1J04_RS08435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1J04_RS08455	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1J04_RS08470	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C1J04_RS08495	COG2885	chlorophyll binding
C1J04_RS08500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1J04_RS08520	COG0175	sulfate reduction
C1J04_RS08525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1J04_RS08540	COG1522	sequence-specific DNA binding
C1J04_RS08560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J04_RS08565	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J04_RS08570	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J04_RS08575	COG0149	triose-phosphate isomerase activity
C1J04_RS08580	COG0316	Belongs to the HesB IscA family
C1J04_RS08590	COG2151	metal-sulfur cluster biosynthetic enzyme
C1J04_RS08595	COG4067	protein conserved in archaea
C1J04_RS08595	COG0189	ligase activity
C1J04_RS08600	COG0343	queuine tRNA-ribosyltransferase activity
C1J04_RS08605	COG1902	pentaerythritol trinitrate reductase activity
C1J04_RS08610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1J04_RS08615	COG0776	regulation of translation
C1J04_RS08625	COG1024	Enoyl-CoA hydratase
C1J04_RS08630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1J04_RS08635	COG1116	anion transmembrane transporter activity
C1J04_RS08640	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C1J04_RS08645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1J04_RS08650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1J04_RS08660	COG2022	thiamine diphosphate biosynthetic process
C1J04_RS08675	COG0351	phosphomethylpyrimidine kinase
C1J04_RS08695	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1J04_RS08710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1J04_RS08715	COG1268	BioY protein
C1J04_RS08725	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C1J04_RS08735	COG1174	glycine betaine transport
C1J04_RS08740	COG1125	glycine betaine transport
C1J04_RS08745	COG1174	glycine betaine transport
C1J04_RS08750	COG1732	Glycine betaine
C1J04_RS08760	COG1473	amidohydrolase
C1J04_RS08780	COG4681	YaeQ
C1J04_RS08805	COG4584	PFAM Integrase catalytic
C1J04_RS08820	COG2433	Pfam Transposase IS66
C1J04_RS08825	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS08920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1J04_RS08920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1J04_RS08935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1J04_RS08940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1J04_RS08950	COG1217	gtp-binding protein TYPA
C1J04_RS08955	COG0668	transmembrane transport
C1J04_RS08960	COG2076	Multidrug Resistance protein
C1J04_RS08970	COG0538	isocitrate dehydrogenase activity
C1J04_RS08985	COG2945	thiolester hydrolase activity
C1J04_RS08990	COG1959	2 iron, 2 sulfur cluster binding
C1J04_RS09000	COG0719	Fe-S assembly protein
C1J04_RS09015	COG0396	ATPase activity
C1J04_RS09020	COG0719	Fe-S assembly protein
C1J04_RS09035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1J04_RS09045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1J04_RS09045	COG2198	Histidine kinase
C1J04_RS09045	COG2205	protein histidine kinase activity
C1J04_RS09045	COG0784	Response regulator, receiver
C1J04_RS09055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C1J04_RS09065	COG0248	Ppx GppA phosphatase
C1J04_RS09070	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1J04_RS09075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1J04_RS09075	COG2111	Na H antiporter
C1J04_RS09080	COG1006	Multisubunit Na H antiporter MnhC subunit
C1J04_RS09085	COG0651	ATP synthesis coupled electron transport
C1J04_RS09090	COG1863	multisubunit Na H antiporter MnhE subunit
C1J04_RS09095	COG2212	antiporter activity
C1J04_RS09100	COG1320	monovalent cation:proton antiporter activity
C1J04_RS09115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J04_RS09120	COG0156	8-amino-7-oxononanoate synthase activity
C1J04_RS09130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1J04_RS09155	COG0436	Aminotransferase
C1J04_RS09165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1J04_RS09170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1J04_RS09190	COG0440	acetolactate synthase activity
C1J04_RS09195	COG0028	Belongs to the TPP enzyme family
C1J04_RS09210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J04_RS09220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J04_RS09225	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C1J04_RS09240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1J04_RS09270	COG1764	response to oxidative stress
C1J04_RS09300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1J04_RS09310	COG0010	Belongs to the arginase family
C1J04_RS09325	COG1238	metal cluster binding
C1J04_RS09355	COG1175	transmembrane transport
C1J04_RS09385	COG4536	flavin adenine dinucleotide binding
C1J04_RS09395	COG4974	Belongs to the 'phage' integrase family
C1J04_RS09405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1J04_RS09410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1J04_RS09415	COG0629	single-stranded DNA binding
C1J04_RS09420	COG1196	nuclear chromosome segregation
C1J04_RS09420	COG0739	heme binding
C1J04_RS09420	COG0741	lytic transglycosylase activity
C1J04_RS09435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J04_RS09440	COG0601	transmembrane transport
C1J04_RS09450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1J04_RS09455	COG0528	UMP kinase activity
C1J04_RS09460	COG0233	cytoplasmic translational termination
C1J04_RS09465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1J04_RS09475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1J04_RS09480	COG0750	zinc metalloprotease
C1J04_RS09485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1J04_RS09495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1J04_RS09500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1J04_RS09505	COG3494	Protein of unknown function (DUF1009)
C1J04_RS09510	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1J04_RS09515	COG0482	sulfurtransferase activity
C1J04_RS09530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1J04_RS09535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1J04_RS09545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1J04_RS09550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1J04_RS09555	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C1J04_RS09575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1J04_RS09580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1J04_RS09585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1J04_RS09590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1J04_RS09595	COG1309	transcriptional regulator
C1J04_RS09600	COG2326	polyphosphate kinase activity
C1J04_RS09605	COG0596	Alpha beta hydrolase
C1J04_RS09610	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C1J04_RS09625	COG0697	spore germination
C1J04_RS09630	COG0519	Catalyzes the synthesis of GMP from XMP
C1J04_RS09630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1J04_RS09635	COG5598	trimethylamine methyltransferase
C1J04_RS09650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1J04_RS09655	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C1J04_RS09660	COG2867	negative regulation of translational initiation
C1J04_RS09665	COG0004	ammonium transporteR
C1J04_RS09675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1J04_RS09680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1J04_RS09680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1J04_RS09685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1J04_RS09690	COG3852	Histidine kinase
C1J04_RS09695	COG2204	response regulator
C1J04_RS09700	COG5000	phosphorelay sensor kinase activity
C1J04_RS09705	COG2204	response regulator
C1J04_RS09715	COG0569	domain protein
C1J04_RS09725	COG1923	regulation of RNA biosynthetic process
C1J04_RS09730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1J04_RS09750	COG2084	Dehydrogenase
C1J04_RS09770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1J04_RS09780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C1J04_RS09795	COG3956	TIGRFAM MazG family protein
C1J04_RS09800	COG1473	amidohydrolase
C1J04_RS09805	COG0010	Belongs to the arginase family
C1J04_RS09820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1J04_RS09825	COG2890	protein-(glutamine-N5) methyltransferase activity
C1J04_RS09835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1J04_RS09840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1J04_RS09845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1J04_RS09850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1J04_RS09865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1J04_RS09875	COG3577	Aspartyl protease
C1J04_RS09880	COG2095	MarC family integral membrane protein
C1J04_RS09885	COG0488	(ABC) transporter
C1J04_RS09890	COG0105	UTP biosynthetic process
C1J04_RS09925	COG1126	abc transporter atp-binding protein
C1J04_RS09935	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1J04_RS09940	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1J04_RS09955	COG0588	phosphoglycerate mutase activity
C1J04_RS09980	COG3743	rRNA binding
C1J04_RS09980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1J04_RS09985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1J04_RS10005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1J04_RS10010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1J04_RS10015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1J04_RS10040	COG0052	Belongs to the universal ribosomal protein uS2 family
C1J04_RS10045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1J04_RS10050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1J04_RS10060	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1J04_RS10065	COG0745	RESPONSE REGULATOR receiver
C1J04_RS10075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1J04_RS10085	COG0573	inorganic phosphate transmembrane transporter activity
C1J04_RS10095	COG5002	protein histidine kinase activity
C1J04_RS10105	COG0194	GDP metabolic process
C1J04_RS10110	COG1561	YicC-like family, N-terminal region
C1J04_RS10120	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C1J04_RS10130	COG2133	pyrroloquinoline quinone binding
C1J04_RS10170	COG0433	COG0433 Predicted ATPase
C1J04_RS10190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1J04_RS10195	COG3409	Peptidoglycan-binding domain 1 protein
C1J04_RS10195	COG3267	Type II secretory pathway component ExeA
C1J04_RS10205	COG1238	metal cluster binding
C1J04_RS10215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1J04_RS10220	COG3264	Mechanosensitive ion channel
C1J04_RS10220	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1J04_RS10230	COG0494	nUDIX hydrolase
C1J04_RS10240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1J04_RS10245	COG0415	Belongs to the DNA photolyase family
C1J04_RS10250	COG0604	alcohol dehydrogenase
C1J04_RS10280	COG0114	fumarate hydratase activity
C1J04_RS10300	COG3588	fructose-bisphosphate aldolase
C1J04_RS10315	COG0785	Cytochrome C biogenesis protein
C1J04_RS10320	COG0425	Belongs to the sulfur carrier protein TusA family
C1J04_RS10325	COG1530	ribonuclease E activity
C1J04_RS10345	COG0047	phosphoribosylformylglycinamidine synthase activity
C1J04_RS10350	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1J04_RS10355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1J04_RS10360	COG1410	methionine synthase
C1J04_RS10360	COG0646	methionine synthase
C1J04_RS10370	COG5012	cobalamin binding
C1J04_RS10380	COG2166	iron-sulfur cluster assembly
C1J04_RS10390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1J04_RS10395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1J04_RS10400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1J04_RS10410	COG2202	Pas domain
C1J04_RS10410	COG2205	protein histidine kinase activity
C1J04_RS10415	COG1012	belongs to the aldehyde dehydrogenase family
C1J04_RS10425	COG0754	glutathionylspermidine amidase activity
C1J04_RS10435	COG0702	epimerase
C1J04_RS10440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1J04_RS10445	COG0720	synthase
C1J04_RS10450	COG0602	queuosine metabolic process
C1J04_RS10455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1J04_RS10460	COG0318	PFAM AMP-dependent synthetase and ligase
C1J04_RS10475	COG0166	Belongs to the GPI family
C1J04_RS10480	COG0363	glucosamine-6-phosphate deaminase activity
C1J04_RS10485	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1J04_RS10500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1J04_RS10510	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C1J04_RS10515	COG1612	heme a metabolic process
C1J04_RS10540	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1J04_RS10540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1J04_RS10545	COG2313	pseudouridylate synthase activity
C1J04_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS10565	COG4166	transmembrane transport
C1J04_RS10590	COG2814	Major facilitator Superfamily
C1J04_RS10595	COG0513	Belongs to the DEAD box helicase family
C1J04_RS10610	COG0148	phosphopyruvate hydratase activity
C1J04_RS10620	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1J04_RS10625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1J04_RS10630	COG0488	(ABC) transporter
C1J04_RS10650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1J04_RS10655	COG0416	fatty acid biosynthetic process
C1J04_RS10660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1J04_RS10665	COG0776	regulation of translation
C1J04_RS10680	COG0717	Belongs to the dCTP deaminase family
C1J04_RS10690	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1J04_RS10695	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C1J04_RS10700	COG1472	Belongs to the glycosyl hydrolase 3 family
C1J04_RS10710	COG0018	arginyl-trna synthetase
C1J04_RS10715	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1J04_RS10720	COG0316	Belongs to the HesB IscA family
C1J04_RS10760	COG2814	Major facilitator Superfamily
C1J04_RS10770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1J04_RS10775	COG0215	cysteine-tRNA ligase activity
C1J04_RS10790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1J04_RS10805	COG1522	sequence-specific DNA binding
C1J04_RS10830	COG4584	PFAM Integrase catalytic
C1J04_RS10840	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS10845	COG4372	Transposase
C1J04_RS10870	COG3795	YCII-related domain
C1J04_RS10875	COG4941	Belongs to the sigma-70 factor family
C1J04_RS10895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1J04_RS10910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1J04_RS10925	COG1278	Cold shock
C1J04_RS10930	COG0259	pyridoxamine-phosphate oxidase activity
C1J04_RS10935	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1J04_RS10940	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C1J04_RS10955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1J04_RS10975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1J04_RS10980	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1J04_RS10985	COG0134	indole-3-glycerol-phosphate synthase activity
C1J04_RS10990	COG0315	cyclic pyranopterin monophosphate synthase activity
C1J04_RS10995	COG0303	'Molybdopterin
C1J04_RS11000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1J04_RS11005	COG2333	competence protein COMEC
C1J04_RS11005	COG0658	competence protein
C1J04_RS11010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1J04_RS11015	COG0372	Belongs to the citrate synthase family
C1J04_RS11025	COG1024	Enoyl-CoA hydratase
C1J04_RS11030	COG3088	subunit of a heme lyase
C1J04_RS11035	COG1138	Cytochrome C-type biogenesis protein
C1J04_RS11050	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C1J04_RS11055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1J04_RS11060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1J04_RS11080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1J04_RS11090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1J04_RS11100	COG0418	dihydroorotase activity
C1J04_RS11105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1J04_RS11110	COG0305	Participates in initiation and elongation during chromosome replication
C1J04_RS11125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1J04_RS11150	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1J04_RS11160	COG4221	oxidoreductase activity
C1J04_RS11165	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C1J04_RS11170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1J04_RS11185	COG0805	protein transport
C1J04_RS11190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1J04_RS11195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1J04_RS11205	COG3842	ATPase activity
C1J04_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS11230	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C1J04_RS11240	COG0513	Belongs to the DEAD box helicase family
C1J04_RS11250	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C1J04_RS11260	COG1007	ATP synthesis coupled electron transport
C1J04_RS11275	COG0713	ATP synthesis coupled electron transport
C1J04_RS11290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1J04_RS11295	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1J04_RS11335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1J04_RS11335	COG3743	rRNA binding
C1J04_RS11345	COG0649	NAD binding
C1J04_RS11350	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1J04_RS11355	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1J04_RS11365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1J04_RS11370	COG1024	Enoyl-CoA hydratase
C1J04_RS11390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1J04_RS11395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1J04_RS11405	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS11415	COG0346	lactoylglutathione lyase activity
C1J04_RS11425	COG0546	phosphoglycolate phosphatase activity
C1J04_RS11430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1J04_RS11450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1J04_RS11455	COG1519	Transferase
C1J04_RS11460	COG0438	transferase activity, transferring glycosyl groups
C1J04_RS11465	COG1473	amidohydrolase
C1J04_RS11470	COG1473	amidohydrolase
C1J04_RS11475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1J04_RS11480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J04_RS11485	COG4172	Belongs to the ABC transporter superfamily
C1J04_RS11495	COG0601	transmembrane transport
C1J04_RS11500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J04_RS11515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1J04_RS11515	COG3453	Protein conserved in bacteria
C1J04_RS11520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1J04_RS11530	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS11550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1J04_RS11565	COG0308	aminopeptidase N
C1J04_RS11585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1J04_RS11605	COG0484	heat shock protein binding
C1J04_RS11650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1J04_RS11660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1J04_RS11665	COG0849	cell division
C1J04_RS11670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1J04_RS11675	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1J04_RS11680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1J04_RS11700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1J04_RS11705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1J04_RS11720	COG2081	HI0933 family
C1J04_RS11730	COG2814	Major facilitator Superfamily
C1J04_RS11760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1J04_RS11765	COG2066	Belongs to the glutaminase family
C1J04_RS11770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1J04_RS11780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1J04_RS11795	COG0275	rRNA processing
C1J04_RS11800	COG2001	Belongs to the MraZ family
C1J04_RS11805	COG0489	protein tyrosine kinase activity
C1J04_RS11815	COG0210	DNA helicase
C1J04_RS11820	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C1J04_RS11825	COG0346	lactoylglutathione lyase activity
C1J04_RS11835	COG1610	YqeY-like protein
C1J04_RS11840	COG0505	Belongs to the CarA family
C1J04_RS11850	COG1802	Transcriptional regulator
C1J04_RS11860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1J04_RS11870	COG1522	sequence-specific DNA binding
C1J04_RS11880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1J04_RS11890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1J04_RS11895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1J04_RS11900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1J04_RS11910	COG0574	Belongs to the PEP-utilizing enzyme family
C1J04_RS11910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1J04_RS11915	COG0751	glycine-tRNA ligase activity
C1J04_RS11925	COG0752	glycyl-tRNA synthetase alpha subunit
C1J04_RS11940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1J04_RS11950	COG1469	GTP cyclohydrolase I activity
C1J04_RS11960	COG2917	probably involved in intracellular septation
C1J04_RS11970	COG0552	protein localization to endoplasmic reticulum
C1J04_RS11980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1J04_RS11985	COG3239	Fatty acid desaturase
C1J04_RS11995	COG1570	exodeoxyribonuclease VII activity
C1J04_RS12020	COG1120	ATPase activity
C1J04_RS12025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1J04_RS12030	COG0628	permease
C1J04_RS12050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1J04_RS12070	COG0729	surface antigen
C1J04_RS12095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1J04_RS12115	COG0321	lipoyl(octanoyl) transferase activity
C1J04_RS12160	COG0131	Imidazoleglycerol-phosphate dehydratase
C1J04_RS12165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1J04_RS12180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1J04_RS12185	COG0107	imidazoleglycerol-phosphate synthase activity
C1J04_RS12190	COG0140	phosphoribosyl-ATP diphosphatase activity
C1J04_RS12195	COG1832	CoA-binding protein
C1J04_RS12205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1J04_RS12215	COG2873	o-acetylhomoserine
C1J04_RS12220	COG2968	Membrane
C1J04_RS12245	COG1329	Transcriptional regulator
C1J04_RS12250	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1J04_RS12255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C1J04_RS12275	COG2267	carboxylic ester hydrolase activity
C1J04_RS12285	COG1793	dna ligase
C1J04_RS12295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1J04_RS12310	COG0564	pseudouridine synthase activity
C1J04_RS12345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1J04_RS12350	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1J04_RS12355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1J04_RS12355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1J04_RS12385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1J04_RS12385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1J04_RS12390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1J04_RS12395	COG4221	oxidoreductase activity
C1J04_RS12400	COG0432	Pfam Uncharacterised protein family UPF0047
C1J04_RS12415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1J04_RS12420	COG0358	DNA primase activity
C1J04_RS12430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1J04_RS12465	COG1595	DNA-templated transcription, initiation
C1J04_RS12490	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J04_RS12490	COG0824	Thioesterase
C1J04_RS12500	COG3246	L-lysine catabolic process to acetate
C1J04_RS12505	COG0667	Aldo Keto reductase
C1J04_RS12515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1J04_RS12525	COG3328	transposase activity
C1J04_RS12540	COG1522	sequence-specific DNA binding
C1J04_RS12560	COG0483	inositol monophosphate 1-phosphatase activity
C1J04_RS12565	COG2130	NADP-dependent
C1J04_RS12580	COG0583	DNA-binding transcription factor activity
C1J04_RS12600	COG0525	valine-tRNA ligase activity
C1J04_RS12610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1J04_RS12625	COG1132	(ABC) transporter
C1J04_RS12635	COG0354	folic acid binding
C1J04_RS12640	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1J04_RS12675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1J04_RS12685	COG1454	alcohol dehydrogenase
C1J04_RS12695	COG0527	aspartate kinase activity
C1J04_RS12710	COG0725	ABC transporter, periplasmic molybdate-binding protein
C1J04_RS12715	COG4149	molybdate abc transporter
C1J04_RS12740	COG0659	secondary active sulfate transmembrane transporter activity
C1J04_RS12745	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C1J04_RS12750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1J04_RS12790	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1J04_RS12795	COG0135	phosphoribosylanthranilate isomerase activity
C1J04_RS12805	COG0776	regulation of translation
C1J04_RS12810	COG0539	negative regulation of cytoplasmic translation
C1J04_RS12820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1J04_RS12825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1J04_RS12830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1J04_RS12835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1J04_RS12840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1J04_RS12845	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1J04_RS12850	COG1253	flavin adenine dinucleotide binding
C1J04_RS12855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1J04_RS12860	COG1702	phosphate starvation-inducible protein PhoH
C1J04_RS12875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1J04_RS12890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1J04_RS12895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1J04_RS12900	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1J04_RS12910	COG1047	Peptidyl-prolyl cis-trans
C1J04_RS12930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1J04_RS12955	COG4948	Mandelate Racemase Muconate Lactonizing
C1J04_RS12960	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS12965	COG0583	DNA-binding transcription factor activity
C1J04_RS12975	COG0737	Belongs to the 5'-nucleotidase family
C1J04_RS12995	COG0534	Mate efflux family protein
C1J04_RS13020	COG2197	response regulator
C1J04_RS13025	COG0789	Transcriptional regulator
C1J04_RS13030	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS13040	COG0625	glutathione transferase activity
C1J04_RS13045	COG0183	Belongs to the thiolase family
C1J04_RS13065	COG0318	PFAM AMP-dependent synthetase and ligase
C1J04_RS13085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1J04_RS13090	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C1J04_RS13105	COG0280	phosphate acetyltransferase
C1J04_RS13105	COG0281	malic enzyme
C1J04_RS13120	COG3237	CsbD-like
C1J04_RS13125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1J04_RS13130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1J04_RS13140	COG0596	Alpha beta hydrolase
C1J04_RS13145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1J04_RS13155	COG1435	thymidine kinase activity
C1J04_RS13165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1J04_RS13185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1J04_RS13195	COG1496	oxidoreductase activity
C1J04_RS13205	COG1522	sequence-specific DNA binding
C1J04_RS13210	COG0492	ferredoxin-NADP+ reductase activity
C1J04_RS13240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1J04_RS13245	COG3454	Phosphonate metabolism
C1J04_RS13265	COG0459	protein refolding
C1J04_RS13270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1J04_RS13280	COG1227	inorganic diphosphatase activity
C1J04_RS13290	COG1309	transcriptional regulator
C1J04_RS13300	COG2030	dehydratase
C1J04_RS13305	COG0196	riboflavin kinase activity
C1J04_RS13310	COG2983	Belongs to the UPF0260 family
C1J04_RS13340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1J04_RS13345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1J04_RS13350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1J04_RS13355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1J04_RS13360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1J04_RS13370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1J04_RS13395	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C1J04_RS13410	COG0287	Prephenate dehydrogenase
C1J04_RS13415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1J04_RS13420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1J04_RS13425	COG0745	RESPONSE REGULATOR receiver
C1J04_RS13430	COG0519	Catalyzes the synthesis of GMP from XMP
C1J04_RS13455	COG2890	protein-(glutamine-N5) methyltransferase activity
C1J04_RS13465	COG0142	geranyltranstransferase activity
C1J04_RS13470	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1J04_RS13485	COG0789	Transcriptional regulator
C1J04_RS13495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1J04_RS13505	COG0303	'Molybdopterin
C1J04_RS13555	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS13560	COG0009	L-threonylcarbamoyladenylate synthase
C1J04_RS13565	COG1678	Uncharacterized ACR, COG1678
C1J04_RS13575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1J04_RS13585	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1J04_RS13590	COG1280	lysine exporter protein (LysE YggA)
C1J04_RS13595	COG1573	uracil-dna glycosylase
C1J04_RS13600	COG0540	Belongs to the ATCase OTCase family
C1J04_RS13625	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1J04_RS13645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1J04_RS13650	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1J04_RS13655	COG2885	chlorophyll binding
C1J04_RS13665	COG0314	molybdopterin synthase activity
C1J04_RS13675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1J04_RS13680	COG0322	excinuclease ABC activity
C1J04_RS13700	COG0842	Transport permease protein
C1J04_RS13705	COG1131	(ABC) transporter
C1J04_RS13715	COG0604	alcohol dehydrogenase
C1J04_RS13715	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS13715	COG3321	synthase
C1J04_RS13725	COG1294	oxidase, subunit
C1J04_RS13730	COG1271	oxidase subunit
C1J04_RS13735	COG2205	protein histidine kinase activity
C1J04_RS13755	COG1012	belongs to the aldehyde dehydrogenase family
C1J04_RS13760	COG0174	glutamine synthetase
C1J04_RS13790	COG0019	diaminopimelate decarboxylase activity
C1J04_RS13805	COG2205	protein histidine kinase activity
C1J04_RS13810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1J04_RS13820	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1J04_RS13825	COG0594	ribonuclease P activity
C1J04_RS13830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1J04_RS13835	COG0037	tRNA processing
C1J04_RS13845	COG0706	membrane insertase activity
C1J04_RS13855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1J04_RS13860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1J04_RS13870	COG1126	abc transporter atp-binding protein
C1J04_RS13875	COG0765	amino acid transport
C1J04_RS13880	COG4597	amino acid ABC transporter
C1J04_RS13885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1J04_RS13900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1J04_RS13905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1J04_RS13910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1J04_RS13915	COG0203	ribosomal protein L17
C1J04_RS13920	COG0202	RNA polymerase activity
C1J04_RS13925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1J04_RS13930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1J04_RS13935	COG0563	adenylate kinase activity
C1J04_RS13940	COG0201	protein transport
C1J04_RS13945	COG0200	Binds to the 23S rRNA
C1J04_RS13950	COG1841	ribosomal large subunit assembly
C1J04_RS13955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1J04_RS13960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1J04_RS13965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1J04_RS13970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1J04_RS13975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1J04_RS13980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1J04_RS13985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1J04_RS13990	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1J04_RS13995	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1J04_RS14000	COG0255	Belongs to the universal ribosomal protein uL29 family
C1J04_RS14020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1J04_RS14025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1J04_RS14030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1J04_RS14035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1J04_RS14040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1J04_RS14050	COG0089	rRNA binding
C1J04_RS14055	COG0088	Forms part of the polypeptide exit tunnel
C1J04_RS14060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1J04_RS14065	COG0051	transcription antitermination factor activity, RNA binding
C1J04_RS14070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1J04_RS14075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1J04_RS14080	COG0049	tRNA binding
C1J04_RS14085	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1J04_RS14095	COG0697	spore germination
C1J04_RS14100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1J04_RS14105	COG0085	RNA polymerase activity
C1J04_RS14110	COG0222	ribosome binding
C1J04_RS14115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1J04_RS14120	COG0081	regulation of translation
C1J04_RS14125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1J04_RS14130	COG0250	Participates in transcription elongation, termination and antitermination
C1J04_RS14145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1J04_RS14175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1J04_RS14185	COG0300	oxidoreductase activity
C1J04_RS14195	COG2096	Adenosyltransferase
C1J04_RS14215	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J04_RS14225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1J04_RS14235	COG1660	Displays ATPase and GTPase activities
C1J04_RS14245	COG2205	protein histidine kinase activity
C1J04_RS14250	COG0745	RESPONSE REGULATOR receiver
C1J04_RS14255	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1J04_RS14270	COG1396	sequence-specific DNA binding
C1J04_RS14290	COG2963	transposase activity
C1J04_RS14295	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS14300	COG4372	Transposase
C1J04_RS14305	COG3012	SEC-C Motif Domain Protein
C1J04_RS14315	COG1381	Involved in DNA repair and RecF pathway recombination
C1J04_RS14325	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1J04_RS14330	COG0571	ribonuclease III activity
C1J04_RS14335	COG0681	Belongs to the peptidase S26 family
C1J04_RS14340	COG0736	holo-[acyl-carrier-protein] synthase activity
C1J04_RS14345	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1J04_RS14355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1J04_RS14360	COG1758	RNA polymerase activity
C1J04_RS14365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1J04_RS14375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1J04_RS14385	COG0328	RNA-DNA hybrid ribonuclease activity
C1J04_RS14390	COG2860	membrane
C1J04_RS14400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1J04_RS14405	COG0242	peptide deformylase activity
C1J04_RS14410	COG0242	peptide deformylase activity
C1J04_RS14415	COG0242	peptide deformylase activity
C1J04_RS14420	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1J04_RS14430	COG0435	Glutathione S-transferase
C1J04_RS14450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1J04_RS14455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1J04_RS14460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1J04_RS14465	COG0356	it plays a direct role in the translocation of protons across the membrane
C1J04_RS14490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1J04_RS14495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1J04_RS14505	COG0228	four-way junction DNA binding
C1J04_RS14510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1J04_RS14515	COG0336	Belongs to the RNA methyltransferase TrmD family
C1J04_RS14520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1J04_RS14525	COG0335	large ribosomal subunit rRNA binding
C1J04_RS14530	COG0254	rRNA binding
C1J04_RS14540	COG0489	protein tyrosine kinase activity
C1J04_RS14540	COG2151	metal-sulfur cluster biosynthetic enzyme
C1J04_RS14550	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1J04_RS14580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1J04_RS14585	COG0181	hydroxymethylbilane synthase activity
C1J04_RS14590	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C1J04_RS14595	COG0408	coproporphyrinogen oxidase activity
C1J04_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS14610	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1J04_RS14620	COG1686	Belongs to the peptidase S11 family
C1J04_RS14625	COG4172	Belongs to the ABC transporter superfamily
C1J04_RS14630	COG4239	(ABC) transporter, permease
C1J04_RS14635	COG4174	ABC transporter (Permease)
C1J04_RS14650	COG0077	Prephenate dehydratase
C1J04_RS14660	COG2816	NAD+ diphosphatase activity
C1J04_RS14670	COG2321	neutral zinc metallopeptidase
C1J04_RS14680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1J04_RS14690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1J04_RS14695	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J04_RS14725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1J04_RS14735	COG1268	BioY protein
C1J04_RS14740	COG1492	cobalamin metabolic process
C1J04_RS14780	COG2099	Precorrin-6x reductase
C1J04_RS14795	COG2875	Belongs to the precorrin methyltransferase family
C1J04_RS14800	COG1797	cobyrinic acid a,c-diamide synthase activity
C1J04_RS14805	COG1648	precorrin-2 dehydrogenase activity
C1J04_RS14805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1J04_RS14835	COG1216	Glycosyl transferase, family 2
C1J04_RS14850	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1J04_RS14855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1J04_RS14860	COG1063	alcohol dehydrogenase
C1J04_RS14865	COG0156	8-amino-7-oxononanoate synthase activity
C1J04_RS14870	COG1396	sequence-specific DNA binding
C1J04_RS14880	COG2226	methyltransferase
C1J04_RS14885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1J04_RS14890	COG1024	Enoyl-CoA hydratase
C1J04_RS14895	COG0268	Binds directly to 16S ribosomal RNA
C1J04_RS14900	COG1192	Involved in chromosome partitioning
C1J04_RS14905	COG1475	DNA binding
C1J04_RS14910	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1J04_RS14945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1J04_RS14950	COG2010	Cytochrome c
C1J04_RS14950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1J04_RS14955	COG0531	amino acid
C1J04_RS14960	COG0586	Pfam SNARE associated Golgi protein
C1J04_RS14990	COG1285	pathogenesis
C1J04_RS15000	COG2032	superoxide dismutase activity
C1J04_RS15010	COG0783	Belongs to the Dps family
C1J04_RS15020	COG4774	siderophore transport
C1J04_RS15025	COG2814	Major facilitator Superfamily
C1J04_RS15050	COG1024	Enoyl-CoA hydratase
C1J04_RS15065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1J04_RS15070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1J04_RS15100	COG2855	membrane
C1J04_RS15110	COG2205	protein histidine kinase activity
C1J04_RS15145	COG1309	transcriptional regulator
C1J04_RS15170	COG2205	protein histidine kinase activity
C1J04_RS15215	COG3181	Tripartite tricarboxylate transporter family receptor
C1J04_RS15220	COG0583	DNA-binding transcription factor activity
C1J04_RS15250	COG2132	Multicopper oxidase
C1J04_RS15265	COG1629	transport
C1J04_RS15270	COG3720	iron ion transport
C1J04_RS15275	COG4558	Periplasmic binding protein
C1J04_RS15280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1J04_RS15285	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1J04_RS15290	COG3920	Histidine kinase
C1J04_RS15290	COG2202	Pas domain
C1J04_RS15305	COG1573	uracil-dna glycosylase
C1J04_RS15330	COG4585	Histidine kinase
C1J04_RS15365	COG1609	Transcriptional regulator
C1J04_RS15380	COG3836	Belongs to the HpcH HpaI aldolase family
C1J04_RS15385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1J04_RS15395	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1J04_RS15425	COG2188	Transcriptional regulator
C1J04_RS15430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1J04_RS15435	COG0066	3-isopropylmalate dehydratase activity
C1J04_RS15440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J04_RS15475	COG4584	PFAM Integrase catalytic
C1J04_RS15485	COG0582	viral genome integration into host DNA
C1J04_RS15560	COG2963	transposase activity
C1J04_RS15570	COG4372	Transposase
C1J04_RS15640	COG4584	PFAM Integrase catalytic
C1J04_RS15665	COG2826	transposase and inactivated derivatives, IS30 family
C1J04_RS15680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1J04_RS15685	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS15695	COG1024	Enoyl-CoA hydratase
C1J04_RS15700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1J04_RS15705	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS15720	COG0511	ligase activity, forming carbon-carbon bonds
C1J04_RS15720	COG5016	pyruvate
C1J04_RS15735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1J04_RS15740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1J04_RS15770	COG1022	Amp-dependent synthetase and ligase
C1J04_RS15790	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS15795	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS15800	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS15805	COG1024	Enoyl-CoA hydratase
C1J04_RS15820	COG1309	transcriptional regulator
C1J04_RS15825	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS15850	COG3012	SEC-C Motif Domain Protein
C1J04_RS15855	COG4372	Transposase
C1J04_RS15860	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS15865	COG2963	transposase activity
C1J04_RS15875	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1J04_RS15875	COG1902	pentaerythritol trinitrate reductase activity
C1J04_RS15880	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS15895	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C1J04_RS15900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1J04_RS15915	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS15925	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS15930	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C1J04_RS15970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J04_RS15975	COG1024	Enoyl-CoA hydratase
C1J04_RS15985	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS16005	COG3012	SEC-C Motif Domain Protein
C1J04_RS16010	COG4372	Transposase
C1J04_RS16015	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS16020	COG2963	transposase activity
C1J04_RS16040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J04_RS16060	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS16065	COG0183	Belongs to the thiolase family
C1J04_RS16075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J04_RS16090	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C1J04_RS16115	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS16130	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS16135	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS16165	COG0183	Belongs to the thiolase family
C1J04_RS16185	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS16190	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS16195	COG2030	dehydratase
C1J04_RS16205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J04_RS16210	COG2030	dehydratase
C1J04_RS16215	COG0183	Belongs to the thiolase family
C1J04_RS16230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J04_RS16240	COG3012	SEC-C Motif Domain Protein
C1J04_RS16245	COG4372	Transposase
C1J04_RS16250	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS16255	COG2963	transposase activity
C1J04_RS16260	COG1024	Enoyl-CoA hydratase
C1J04_RS16265	COG1024	Enoyl-CoA hydratase
C1J04_RS16290	COG0559	Belongs to the binding-protein-dependent transport system permease family
C1J04_RS16315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1J04_RS16335	COG1846	Transcriptional regulator
C1J04_RS16375	COG1231	oxidoreductase activity
C1J04_RS16400	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS16455	COG4584	PFAM Integrase catalytic
C1J04_RS16460	COG0517	IMP dehydrogenase activity
C1J04_RS16460	COG4175	Glycine betaine
C1J04_RS16465	COG4176	ABC-type proline glycine betaine transport system permease component
C1J04_RS16490	COG0559	Belongs to the binding-protein-dependent transport system permease family
C1J04_RS16495	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1J04_RS16505	COG0318	PFAM AMP-dependent synthetase and ligase
C1J04_RS16520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J04_RS16550	COG0617	tRNA 3'-terminal CCA addition
C1J04_RS16550	COG0517	IMP dehydrogenase activity
C1J04_RS16550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1J04_RS16555	COG0655	NAD(P)H dehydrogenase (quinone) activity
C1J04_RS16575	COG4584	PFAM Integrase catalytic
C1J04_RS16590	COG0587	DNA-directed DNA polymerase activity
C1J04_RS16635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1J04_RS16640	COG1473	amidohydrolase
C1J04_RS16650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1J04_RS16655	COG0601	transmembrane transport
C1J04_RS16660	COG4166	transmembrane transport
C1J04_RS16680	COG1192	Involved in chromosome partitioning
C1J04_RS16700	COG0625	glutathione transferase activity
C1J04_RS16705	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS16710	COG0028	Belongs to the TPP enzyme family
C1J04_RS16720	COG2124	cytochrome p450
C1J04_RS16735	COG1012	belongs to the aldehyde dehydrogenase family
C1J04_RS16740	COG2084	Dehydrogenase
C1J04_RS16745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J04_RS16760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1J04_RS16780	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1J04_RS16790	COG4786	Flagellar basal body rod
C1J04_RS16795	COG4786	Flagellar basal body rod
C1J04_RS16820	COG0745	RESPONSE REGULATOR receiver
C1J04_RS16825	COG1706	bacterial-type flagellum-dependent cell motility
C1J04_RS16855	COG1558	bacterial-type flagellum-dependent cell motility
C1J04_RS16860	COG1677	Flagellar hook-basal body complex protein FliE
C1J04_RS16875	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1J04_RS16885	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1J04_RS16910	COG1766	The M ring may be actively involved in energy transduction
C1J04_RS16920	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1J04_RS16925	COG1338	Plays a role in the flagellum-specific transport system
C1J04_RS16930	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1J04_RS16965	COG4957	zinc ion binding
C1J04_RS16970	COG1360	Flagellar Motor Protein
C1J04_RS16980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1J04_RS16990	COG5002	protein histidine kinase activity
C1J04_RS17045	COG2017	converts alpha-aldose to the beta-anomer
C1J04_RS17055	COG2814	Major facilitator Superfamily
C1J04_RS17065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1J04_RS17090	COG2130	NADP-dependent
C1J04_RS17095	COG3321	synthase
C1J04_RS17095	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS17095	COG0604	alcohol dehydrogenase
C1J04_RS17100	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS17105	COG1960	acyl-CoA dehydrogenase activity
C1J04_RS17115	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS17120	COG0183	Belongs to the thiolase family
C1J04_RS17125	COG0588	phosphoglycerate mutase activity
C1J04_RS17170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1J04_RS17175	COG1946	Acyl-CoA thioesterase
C1J04_RS17190	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS17195	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS17205	COG1024	Enoyl-CoA hydratase
C1J04_RS17210	COG1024	Enoyl-CoA hydratase
C1J04_RS17210	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1J04_RS17215	COG0318	PFAM AMP-dependent synthetase and ligase
C1J04_RS17270	COG0683	leucine binding
C1J04_RS17295	COG2814	Major facilitator Superfamily
C1J04_RS17315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1J04_RS17325	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1J04_RS17330	COG0438	transferase activity, transferring glycosyl groups
C1J04_RS17365	COG0348	domain, Protein
C1J04_RS17370	COG2010	Cytochrome c
C1J04_RS17390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1J04_RS17395	COG1312	Catalyzes the dehydration of D-mannonate
C1J04_RS17400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J04_RS17400	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C1J04_RS17420	COG1028	Short-chain dehydrogenase reductase Sdr
C1J04_RS17430	COG2186	Transcriptional regulator
C1J04_RS17450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C1J04_RS17475	COG1595	DNA-templated transcription, initiation
C1J04_RS17480	COG0745	RESPONSE REGULATOR receiver
C1J04_RS17485	COG5002	protein histidine kinase activity
C1J04_RS17490	COG5002	protein histidine kinase activity
C1J04_RS17505	COG0183	Belongs to the thiolase family
C1J04_RS17520	COG1192	Involved in chromosome partitioning
C1J04_RS17560	COG4644	lycopene metabolic process
C1J04_RS17565	COG3547	Transposase (IS116 IS110 IS902 family)
C1J04_RS17600	COG3328	transposase activity
C1J04_RS17605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1J04_RS17620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1J04_RS17685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1J04_RS17695	COG3318	Belongs to the UPF0149 family
C1J04_RS17695	COG3012	SEC-C Motif Domain Protein
C1J04_RS17735	COG3328	transposase activity
C1J04_RS17760	COG2814	Major facilitator Superfamily
C1J04_RS17765	COG1937	Protein conserved in bacteria
C1J04_RS17805	COG3034	peptidoglycan biosynthetic process
C1J04_RS17815	COG2366	antibiotic biosynthetic process
C1J04_RS17820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1J04_RS17825	COG3012	SEC-C Motif Domain Protein
C1J04_RS17830	COG4372	Transposase
C1J04_RS17835	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS17840	COG2963	transposase activity
C1J04_RS17865	COG1999	signal sequence binding
C1J04_RS17885	COG1999	signal sequence binding
C1J04_RS17890	COG0789	Transcriptional regulator
C1J04_RS17950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1J04_RS17955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1J04_RS17980	COG0785	Cytochrome C biogenesis protein
C1J04_RS18105	COG1196	nuclear chromosome segregation
C1J04_RS18105	COG0741	lytic transglycosylase activity
C1J04_RS18105	COG0739	heme binding
C1J04_RS18125	COG1196	nuclear chromosome segregation
C1J04_RS18125	COG0741	lytic transglycosylase activity
C1J04_RS18125	COG0739	heme binding
C1J04_RS18145	COG2948	multi-organism process
C1J04_RS18150	COG4962	Type ii secretion system protein e
C1J04_RS18185	COG3328	transposase activity
C1J04_RS18200	COG2132	Multicopper oxidase
C1J04_RS18230	COG2826	transposase and inactivated derivatives, IS30 family
C1J04_RS18240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1J04_RS18245	COG1192	Involved in chromosome partitioning
C1J04_RS18250	COG1475	DNA binding
C1J04_RS18255	COG1414	Transcriptional regulator
C1J04_RS18275	COG3550	peptidyl-serine autophosphorylation
C1J04_RS18300	COG3843	relaxase mobilization nuclease domain protein
C1J04_RS18315	COG2433	Pfam Transposase IS66
C1J04_RS18325	COG4644	lycopene metabolic process
C1J04_RS18345	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS18370	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C1J04_RS18375	COG2948	multi-organism process
C1J04_RS18385	COG3736	Type IV secretory pathway, component VirB8
C1J04_RS18405	COG0741	lytic transglycosylase activity
C1J04_RS18405	COG1196	nuclear chromosome segregation
C1J04_RS18405	COG0739	heme binding
C1J04_RS18415	COG3451	type IV secretory pathway VirB4
C1J04_RS18430	COG1196	nuclear chromosome segregation
C1J04_RS18430	COG0741	lytic transglycosylase activity
C1J04_RS18430	COG0739	heme binding
C1J04_RS18500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1J04_RS18520	COG0739	heme binding
C1J04_RS18525	COG0789	Transcriptional regulator
C1J04_RS18550	COG1376	ErfK ybiS ycfS ynhG family protein
C1J04_RS18565	COG4644	lycopene metabolic process
C1J04_RS18645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1J04_RS18655	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS18660	COG2433	Pfam Transposase IS66
C1J04_RS18690	COG1475	DNA binding
C1J04_RS18715	COG3328	transposase activity
C1J04_RS18730	COG1192	Involved in chromosome partitioning
C1J04_RS18740	COG0640	Transcriptional regulator
C1J04_RS18765	COG0629	single-stranded DNA binding
C1J04_RS18805	COG0582	viral genome integration into host DNA
C1J04_RS18860	COG3831	ATPase activity
C1J04_RS18870	COG2963	transposase activity
C1J04_RS18875	COG4974	Belongs to the 'phage' integrase family
C1J04_RS18880	COG4974	Belongs to the 'phage' integrase family
C1J04_RS18885	COG4974	Belongs to the 'phage' integrase family
C1J04_RS18890	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS18895	COG2433	Pfam Transposase IS66
C1J04_RS18900	COG3436	PFAM IS66 Orf2 family protein
C1J04_RS18915	COG4584	PFAM Integrase catalytic
C1J04_RS18930	COG1230	cation diffusion facilitator family transporter
C1J04_RS18945	COG0789	Transcriptional regulator
C1J04_RS18950	COG1999	signal sequence binding
C1J04_RS19015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1J04_RS19030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1J04_RS19040	COG0713	ATP synthesis coupled electron transport
C1J04_RS19055	COG1007	ATP synthesis coupled electron transport
C1J04_RS19095	COG2132	Multicopper oxidase
C1J04_RS19110	COG3328	transposase activity
C1J04_RS19150	COG2433	Pfam Transposase IS66
C1J04_RS19190	COG1007	ATP synthesis coupled electron transport
C1J04_RS19220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1J04_RS19260	COG3609	addiction module antidote protein, CC2985 family