locus-tag	class	description
SACN8_RS00035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SACN8_RS00035	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SACN8_RS00040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SACN8_RS00055	COG3253	May function as heme-dependent peroxidase
SACN8_RS00060	COG0494	nUDIX hydrolase
SACN8_RS00085	COG1011	Hydrolase
SACN8_RS00095	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SACN8_RS00105	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SACN8_RS00115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SACN8_RS00135	COG0492	ferredoxin-NADP+ reductase activity
SACN8_RS00180	COG3118	belongs to the thioredoxin family
SACN8_RS00195	COG0516	GMP reductase activity
SACN8_RS00195	COG0517	IMP dehydrogenase activity
SACN8_RS00210	COG1957	nucleoside hydrolase
SACN8_RS00255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SACN8_RS00255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SACN8_RS00265	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
SACN8_RS00280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SACN8_RS00305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SACN8_RS00340	COG0417	DNA replication proofreading
SACN8_RS00350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SACN8_RS00370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SACN8_RS00375	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SACN8_RS00380	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SACN8_RS00390	COG0200	Binds to the 23S rRNA
SACN8_RS00400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SACN8_RS00410	COG0052	Belongs to the universal ribosomal protein uS2 family
SACN8_RS00415	COG1355	regulation of microtubule-based process
SACN8_RS00425	COG1304	FMN binding
SACN8_RS00430	COG0142	geranyltranstransferase activity
SACN8_RS00435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SACN8_RS00455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SACN8_RS00495	COG0746	molybdenum cofactor guanylyltransferase activity
SACN8_RS00500	COG0303	'Molybdopterin
SACN8_RS00505	COG1763	Mo-molybdopterin cofactor biosynthetic process
SACN8_RS00510	COG2226	methyltransferase
SACN8_RS00530	COG1321	iron dependent repressor
SACN8_RS00535	COG2379	hydroxypyruvate reductase
SACN8_RS00545	COG4208	sulfate ABC transporter
SACN8_RS00555	COG0149	triose-phosphate isomerase activity
SACN8_RS00580	COG0114	fumarate hydratase activity
SACN8_RS00585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SACN8_RS00600	COG1444	tRNA N-acetyltransferase activity
SACN8_RS00610	COG0708	Exodeoxyribonuclease III
SACN8_RS00640	COG0667	Aldo Keto reductase
SACN8_RS00650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SACN8_RS00675	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SACN8_RS00690	COG1607	acyl-coa hydrolase
SACN8_RS00710	COG0446	pyridine nucleotide-disulphide oxidoreductase
SACN8_RS00720	COG2222	sugar isomerase
SACN8_RS00725	COG0215	cysteine-tRNA ligase activity
SACN8_RS00740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SACN8_RS00750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SACN8_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
SACN8_RS00760	COG1573	uracil-dna glycosylase
SACN8_RS00775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SACN8_RS00800	COG1832	CoA-binding protein
SACN8_RS00830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SACN8_RS00830	COG1185	polyribonucleotide nucleotidyltransferase activity
SACN8_RS00830	COG0539	negative regulation of cytoplasmic translation
SACN8_RS00860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SACN8_RS00865	COG3959	Transketolase, thiamine diphosphate binding domain
SACN8_RS00870	COG3958	Transketolase
SACN8_RS00875	COG0077	Prephenate dehydratase
SACN8_RS00875	COG1605	Chorismate mutase
SACN8_RS00880	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SACN8_RS00885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SACN8_RS00890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SACN8_RS00895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SACN8_RS00900	COG0083	homoserine kinase activity
SACN8_RS00905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SACN8_RS00925	COG1199	ATP-dependent helicase activity
SACN8_RS00945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SACN8_RS00955	COG1331	Highly conserved protein containing a thioredoxin domain
SACN8_RS00960	COG1028	Short-chain dehydrogenase reductase Sdr
SACN8_RS00965	COG0792	nuclease activity
SACN8_RS00985	COG1192	Involved in chromosome partitioning
SACN8_RS00995	COG0277	FAD linked oxidase domain protein
SACN8_RS01005	COG1013	pyruvate-flavodoxin oxidoreductase activity
SACN8_RS01010	COG0674	pyruvate-flavodoxin oxidoreductase activity
SACN8_RS01010	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SACN8_RS01035	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SACN8_RS01090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SACN8_RS01100	COG1012	belongs to the aldehyde dehydrogenase family
SACN8_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
SACN8_RS01160	COG1011	Hydrolase
SACN8_RS01165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SACN8_RS01190	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SACN8_RS01195	COG2079	MmgE PrpD family protein
SACN8_RS01200	COG0039	L-malate dehydrogenase activity
SACN8_RS01220	COG0778	Nitroreductase
SACN8_RS01230	COG0066	3-isopropylmalate dehydratase activity
SACN8_RS01235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SACN8_RS01240	COG0805	protein transport
SACN8_RS01250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SACN8_RS01255	COG1116	anion transmembrane transporter activity
SACN8_RS01255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SACN8_RS01265	COG0439	Biotin carboxylase
SACN8_RS01275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SACN8_RS01325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SACN8_RS01330	COG0352	thiamine-phosphate diphosphorylase activity
SACN8_RS01330	COG0351	phosphomethylpyrimidine kinase
SACN8_RS01340	COG1215	transferase activity, transferring glycosyl groups
SACN8_RS01365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SACN8_RS01370	COG1111	helicase
SACN8_RS01370	COG1205	dead DEAH box helicase
SACN8_RS01405	COG0517	IMP dehydrogenase activity
SACN8_RS01405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SACN8_RS01405	COG0617	tRNA 3'-terminal CCA addition
SACN8_RS01425	COG0644	oxidoreductase
SACN8_RS01435	COG0058	SHG alpha-glucan phosphorylase activity
SACN8_RS01445	COG0535	radical SAM domain protein
SACN8_RS01460	COG0277	FAD linked oxidase domain protein
SACN8_RS01465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SACN8_RS01495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SACN8_RS01510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SACN8_RS01515	COG0095	Lipoate-protein ligase
SACN8_RS01525	COG2301	Belongs to the HpcH HpaI aldolase family
SACN8_RS01530	COG2050	protein possibly involved in aromatic compounds catabolism
SACN8_RS01530	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SACN8_RS01540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SACN8_RS01545	COG0644	oxidoreductase
SACN8_RS01555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SACN8_RS01565	COG3383	formate dehydrogenase (NAD+) activity
SACN8_RS01585	COG0730	response to heat
SACN8_RS01590	COG2048	Heterodisulfide reductase, subunit B
SACN8_RS01605	COG0492	ferredoxin-NADP+ reductase activity
SACN8_RS01640	COG0425	Belongs to the sulfur carrier protein TusA family
SACN8_RS01645	COG2210	Belongs to the sulfur carrier protein TusA family
SACN8_RS01655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SACN8_RS01690	COG0095	Lipoate-protein ligase
SACN8_RS01705	COG0509	glycine decarboxylation via glycine cleavage system
SACN8_RS01710	COG0509	glycine decarboxylation via glycine cleavage system
SACN8_RS01715	COG0095	Lipoate-protein ligase
SACN8_RS01765	COG0154	amidase activity
SACN8_RS01775	COG0243	molybdopterin cofactor binding
SACN8_RS01780	COG0475	glutathione-regulated potassium exporter activity
SACN8_RS01790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SACN8_RS01810	COG4106	trans-aconitate 2-methyltransferase activity
SACN8_RS01825	COG0495	leucyl-tRNA aminoacylation
SACN8_RS01835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SACN8_RS01850	COG0037	tRNA processing
SACN8_RS01860	COG1489	DNA binding
SACN8_RS01865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SACN8_RS02005	COG1063	alcohol dehydrogenase
SACN8_RS02020	COG0519	Catalyzes the synthesis of GMP from XMP
SACN8_RS02020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SACN8_RS02025	COG0501	Belongs to the peptidase M48B family
SACN8_RS02030	COG0516	GMP reductase activity
SACN8_RS02030	COG0517	IMP dehydrogenase activity
SACN8_RS02045	COG1830	Aldolase
SACN8_RS02055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SACN8_RS02070	COG0405	Gamma-glutamyltransferase
SACN8_RS02110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SACN8_RS02135	COG1994	Peptidase M50
SACN8_RS02145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SACN8_RS02150	COG0489	protein tyrosine kinase activity
SACN8_RS02200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SACN8_RS02545	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SACN8_RS02575	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SACN8_RS02590	COG1335	isochorismatase
SACN8_RS02595	COG1515	deoxyribonuclease V activity
SACN8_RS02605	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SACN8_RS02610	COG0157	Belongs to the NadC ModD family
SACN8_RS02615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SACN8_RS02615	COG0519	Catalyzes the synthesis of GMP from XMP
SACN8_RS02620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SACN8_RS02630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SACN8_RS02635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SACN8_RS02640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SACN8_RS02650	COG0430	RNA-3'-phosphate cyclase activity
SACN8_RS02705	COG0563	adenylate kinase activity
SACN8_RS02730	COG0200	Binds to the 23S rRNA
SACN8_RS02760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SACN8_RS02765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SACN8_RS02770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SACN8_RS02780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SACN8_RS02785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SACN8_RS02790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SACN8_RS02800	COG0255	Belongs to the universal ribosomal protein uL29 family
SACN8_RS02805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SACN8_RS02815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SACN8_RS02820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SACN8_RS02825	COG0089	rRNA binding
SACN8_RS02835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SACN8_RS02850	COG0473	3-isopropylmalate dehydrogenase activity
SACN8_RS02860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SACN8_RS02865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SACN8_RS02900	COG1185	polyribonucleotide nucleotidyltransferase activity
SACN8_RS02940	COG0012	GTP binding
SACN8_RS02945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SACN8_RS02960	COG2264	protein methyltransferase activity
SACN8_RS02965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SACN8_RS03015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SACN8_RS03040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SACN8_RS03050	COG1047	Peptidyl-prolyl cis-trans
SACN8_RS03060	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SACN8_RS03075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SACN8_RS03115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SACN8_RS03125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SACN8_RS03160	COG0124	histidyl-tRNA synthetase
SACN8_RS03175	COG0459	protein refolding
SACN8_RS03200	COG1980	fructose-bisphosphate aldolase activity
SACN8_RS03205	COG1120	ATPase activity
SACN8_RS03215	COG0477	Major facilitator Superfamily
SACN8_RS03250	COG0051	transcription antitermination factor activity, RNA binding
SACN8_RS03255	COG2895	sulfate adenylyltransferase (ATP) activity
SACN8_RS03255	COG0529	Catalyzes the synthesis of activated sulfate
SACN8_RS03260	COG0049	tRNA binding
SACN8_RS03285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SACN8_RS03295	COG0085	RNA polymerase activity
SACN8_RS03310	COG0105	UTP biosynthetic process
SACN8_RS03325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SACN8_RS03330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SACN8_RS03335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SACN8_RS03345	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SACN8_RS03360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SACN8_RS03375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SACN8_RS03385	COG1522	sequence-specific DNA binding
SACN8_RS03395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SACN8_RS03415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SACN8_RS03415	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SACN8_RS03430	COG1056	cytidyltransferase-related domain
SACN8_RS03430	COG1051	belongs to the nudix hydrolase family
SACN8_RS03475	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SACN8_RS03505	COG1131	(ABC) transporter
SACN8_RS03570	COG0517	IMP dehydrogenase activity
SACN8_RS03570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SACN8_RS03585	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SACN8_RS03590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SACN8_RS03605	COG0189	ligase activity
SACN8_RS03610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SACN8_RS03615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SACN8_RS03620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SACN8_RS03645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SACN8_RS03655	COG0028	Belongs to the TPP enzyme family
SACN8_RS03680	COG0017	Asparaginyl-tRNA synthetase
SACN8_RS03700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SACN8_RS03710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SACN8_RS03710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SACN8_RS03715	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SACN8_RS03715	COG1648	precorrin-2 dehydrogenase activity
SACN8_RS03720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SACN8_RS03725	COG0113	porphobilinogen synthase activity
SACN8_RS03730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SACN8_RS03735	COG0181	hydroxymethylbilane synthase activity
SACN8_RS03760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SACN8_RS03770	COG1793	dna ligase
SACN8_RS03775	COG0717	Belongs to the dCTP deaminase family
SACN8_RS03790	COG2078	PFAM AMMECR1 domain protein
SACN8_RS03820	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SACN8_RS03835	COG0504	CTP synthase activity
SACN8_RS03840	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SACN8_RS03860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SACN8_RS03875	COG2813	Specifically methylates the guanine in position
SACN8_RS03880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SACN8_RS03885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SACN8_RS03895	COG1201	RNA secondary structure unwinding
SACN8_RS03925	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SACN8_RS03935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SACN8_RS03935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SACN8_RS03950	COG1797	cobyrinic acid a,c-diamide synthase activity
SACN8_RS03960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SACN8_RS03965	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SACN8_RS03985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SACN8_RS03995	COG0539	negative regulation of cytoplasmic translation
SACN8_RS04010	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SACN8_RS04015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SACN8_RS04020	COG1110	DNA topoisomerase II activity
SACN8_RS04065	COG0667	Aldo Keto reductase
SACN8_RS04070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SACN8_RS04080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SACN8_RS04090	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SACN8_RS04095	COG0163	prenyltransferase activity
SACN8_RS04125	COG0423	glycine-tRNA ligase activity
SACN8_RS04135	COG0023	Translation Initiation Factor
SACN8_RS04165	COG0501	Belongs to the peptidase M48B family
SACN8_RS04185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SACN8_RS04215	COG0004	ammonium transporteR
SACN8_RS04225	COG4948	Mandelate Racemase Muconate Lactonizing
SACN8_RS04230	COG2271	Major facilitator Superfamily
SACN8_RS04235	COG0589	response to stress
SACN8_RS04240	COG0402	S-adenosylhomocysteine deaminase activity
SACN8_RS04325	COG0315	cyclic pyranopterin monophosphate synthase activity
SACN8_RS04330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SACN8_RS04340	COG1881	PFAM PEBP family protein
SACN8_RS04345	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SACN8_RS04350	COG0154	amidase activity
SACN8_RS04355	COG1063	alcohol dehydrogenase
SACN8_RS04370	COG1648	precorrin-2 dehydrogenase activity
SACN8_RS04370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SACN8_RS04385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SACN8_RS04405	COG0071	Belongs to the small heat shock protein (HSP20) family
SACN8_RS04410	COG0346	lactoylglutathione lyase activity
SACN8_RS04415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SACN8_RS04415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SACN8_RS04435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SACN8_RS04445	COG0492	ferredoxin-NADP+ reductase activity
SACN8_RS04460	COG0720	synthase
SACN8_RS04490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SACN8_RS04495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SACN8_RS04520	COG1131	(ABC) transporter
SACN8_RS04550	COG0351	phosphomethylpyrimidine kinase
SACN8_RS04560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SACN8_RS04595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SACN8_RS04600	COG0183	Belongs to the thiolase family
SACN8_RS04645	COG0083	homoserine kinase activity
SACN8_RS04650	COG0303	'Molybdopterin
SACN8_RS04665	COG0714	Associated with various cellular activities
SACN8_RS04670	COG2304	oxidoreductase activity
SACN8_RS04690	COG1053	succinate dehydrogenase
SACN8_RS04695	COG0647	UMP catabolic process
SACN8_RS04710	COG0644	oxidoreductase
SACN8_RS04740	COG1522	sequence-specific DNA binding
SACN8_RS04745	COG0189	ligase activity
SACN8_RS04750	COG0142	geranyltranstransferase activity
SACN8_RS04760	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SACN8_RS04765	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SACN8_RS04805	COG1131	(ABC) transporter
SACN8_RS04825	COG0463	Glycosyl transferase, family 2
SACN8_RS04845	COG0006	proline dipeptidase activity
SACN8_RS04850	COG0123	including yeast histone deacetylase and acetoin utilization protein
SACN8_RS04875	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SACN8_RS04875	COG3608	succinylglutamate desuccinylase aspartoacylase
SACN8_RS04885	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SACN8_RS04890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SACN8_RS04895	COG0671	phosphoesterase, PA-phosphatase related
SACN8_RS04905	COG1131	(ABC) transporter
SACN8_RS04910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SACN8_RS04920	COG2226	methyltransferase
SACN8_RS04930	COG0537	adenosine 5'-monophosphoramidase activity
SACN8_RS04940	COG4608	Belongs to the ABC transporter superfamily
SACN8_RS04945	COG0444	Belongs to the ABC transporter superfamily
SACN8_RS04950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SACN8_RS04955	COG0601	transmembrane transport
SACN8_RS04980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SACN8_RS04990	COG2814	Major facilitator Superfamily
SACN8_RS05025	COG4274	PFAM GYD family protein
SACN8_RS05035	COG0318	PFAM AMP-dependent synthetase and ligase
SACN8_RS05045	COG0076	glutamate decarboxylase activity
SACN8_RS05050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SACN8_RS05055	COG2223	nitrite transmembrane transporter activity
SACN8_RS05105	COG1960	acyl-CoA dehydrogenase activity
SACN8_RS05115	COG1960	acyl-CoA dehydrogenase activity
SACN8_RS05120	COG0402	S-adenosylhomocysteine deaminase activity
SACN8_RS05150	COG1250	3-hydroxyacyl-CoA dehydrogenase
SACN8_RS05170	COG0318	PFAM AMP-dependent synthetase and ligase
SACN8_RS05175	COG1607	acyl-coa hydrolase
SACN8_RS05200	COG2149	membrane
SACN8_RS05205	COG0697	spore germination
SACN8_RS05235	COG1012	belongs to the aldehyde dehydrogenase family
SACN8_RS05245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SACN8_RS05250	COG1028	Short-chain dehydrogenase reductase Sdr
SACN8_RS05260	COG1028	Short-chain dehydrogenase reductase Sdr
SACN8_RS05275	COG1309	transcriptional regulator
SACN8_RS05280	COG1960	acyl-CoA dehydrogenase activity
SACN8_RS05285	COG1024	Enoyl-CoA hydratase
SACN8_RS05290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SACN8_RS05295	COG0318	PFAM AMP-dependent synthetase and ligase
SACN8_RS05300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SACN8_RS05305	COG1960	acyl-CoA dehydrogenase activity
SACN8_RS05310	COG0183	Belongs to the thiolase family
SACN8_RS05315	COG1063	alcohol dehydrogenase
SACN8_RS05320	COG0657	acetylesterase activity
SACN8_RS05330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SACN8_RS05350	COG0318	PFAM AMP-dependent synthetase and ligase
SACN8_RS05355	COG1960	acyl-CoA dehydrogenase activity
SACN8_RS05365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SACN8_RS05370	COG0318	PFAM AMP-dependent synthetase and ligase
SACN8_RS05375	COG0531	amino acid
SACN8_RS05395	COG3511	phospholipase C
SACN8_RS05410	COG1024	Enoyl-CoA hydratase
SACN8_RS05420	COG0028	Belongs to the TPP enzyme family
SACN8_RS05450	COG3384	dioxygenase
SACN8_RS05475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SACN8_RS05480	COG0442	prolyl-tRNA aminoacylation
SACN8_RS05545	COG1175	transmembrane transport
SACN8_RS05555	COG3842	ATPase activity
SACN8_RS05560	COG0517	IMP dehydrogenase activity
SACN8_RS05560	COG0617	tRNA 3'-terminal CCA addition
SACN8_RS05560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SACN8_RS05570	COG3634	alkyl hydroperoxide reductase activity
SACN8_RS05575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SACN8_RS05595	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SACN8_RS05630	COG0515	serine threonine protein kinase
SACN8_RS05635	COG2814	Major facilitator Superfamily
SACN8_RS05645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SACN8_RS05665	COG0277	FAD linked oxidase domain protein
SACN8_RS05675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SACN8_RS05680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SACN8_RS05690	COG0515	serine threonine protein kinase
SACN8_RS05690	COG2815	serine threonine protein kinase
SACN8_RS05695	COG0251	oxidation-reduction process
SACN8_RS05700	COG0516	GMP reductase activity
SACN8_RS05700	COG0517	IMP dehydrogenase activity
SACN8_RS05715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SACN8_RS05725	COG0297	glycogen (starch) synthase activity
SACN8_RS05730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SACN8_RS05755	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SACN8_RS05785	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SACN8_RS05820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SACN8_RS05825	COG1121	(ABC) transporter
SACN8_RS05850	COG0415	Belongs to the DNA photolyase family
SACN8_RS05865	COG0351	phosphomethylpyrimidine kinase
SACN8_RS05865	COG0352	thiamine-phosphate diphosphorylase activity
SACN8_RS05865	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SACN8_RS05875	COG1028	Short-chain dehydrogenase reductase Sdr
SACN8_RS05905	COG2860	membrane
SACN8_RS05950	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SACN8_RS05960	COG0438	transferase activity, transferring glycosyl groups
SACN8_RS05965	COG3387	PFAM Glycoside hydrolase 15-related
SACN8_RS05975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SACN8_RS05975	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SACN8_RS05980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SACN8_RS06015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SACN8_RS06020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SACN8_RS06025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SACN8_RS06040	COG0045	succinate-CoA ligase (ADP-forming) activity
SACN8_RS06090	COG1185	polyribonucleotide nucleotidyltransferase activity
SACN8_RS06125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SACN8_RS06135	COG1234	tRNA 3'-trailer cleavage
SACN8_RS06150	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SACN8_RS06180	COG0300	oxidoreductase activity
SACN8_RS06195	COG4152	abc transporter atp-binding protein
SACN8_RS06220	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SACN8_RS06235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SACN8_RS06245	COG0528	UMP kinase activity
SACN8_RS06255	COG1028	Short-chain dehydrogenase reductase Sdr
SACN8_RS06265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SACN8_RS06270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SACN8_RS06300	COG1201	RNA secondary structure unwinding
SACN8_RS06310	COG1110	DNA topoisomerase II activity
SACN8_RS06345	COG1324	tolerance protein
SACN8_RS06355	COG0154	amidase activity
SACN8_RS06370	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SACN8_RS06370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SACN8_RS06420	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
SACN8_RS06450	COG0252	asparaginase activity
SACN8_RS06455	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SACN8_RS06470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SACN8_RS06480	COG0126	phosphoglycerate kinase activity
SACN8_RS06490	COG0589	response to stress
SACN8_RS06495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SACN8_RS06515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SACN8_RS06520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SACN8_RS06540	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
SACN8_RS06545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SACN8_RS06560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SACN8_RS06565	COG1222	aaa ATPase
SACN8_RS06605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SACN8_RS06610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SACN8_RS06615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SACN8_RS06620	COG0509	glycine decarboxylation via glycine cleavage system
SACN8_RS06640	COG0396	ATPase activity
SACN8_RS06665	COG0604	alcohol dehydrogenase
SACN8_RS06700	COG0459	protein refolding
SACN8_RS06735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SACN8_RS06745	COG0587	DNA-directed DNA polymerase activity
SACN8_RS06755	COG0460	homoserine dehydrogenase
SACN8_RS06755	COG0527	aspartate kinase activity
SACN8_RS06780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SACN8_RS06780	COG0574	Belongs to the PEP-utilizing enzyme family
SACN8_RS06795	COG1254	Belongs to the acylphosphatase family
SACN8_RS06800	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SACN8_RS06810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SACN8_RS06815	COG0135	phosphoribosylanthranilate isomerase activity
SACN8_RS06820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SACN8_RS06825	COG0512	Glutamine amidotransferase of anthranilate synthase
SACN8_RS06825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SACN8_RS06830	COG0134	indole-3-glycerol-phosphate synthase activity
SACN8_RS06835	COG0436	Aminotransferase
SACN8_RS06840	COG0525	valine-tRNA ligase activity
SACN8_RS06945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SACN8_RS06955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SACN8_RS06960	COG0081	regulation of translation
SACN8_RS06965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SACN8_RS06980	COG0552	protein localization to endoplasmic reticulum
SACN8_RS07030	COG2848	UPF0210 protein
SACN8_RS07045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SACN8_RS07055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SACN8_RS07060	COG0006	proline dipeptidase activity
SACN8_RS07065	COG0302	gtp cyclohydrolase
SACN8_RS07080	COG3842	ATPase activity
SACN8_RS07085	COG3118	belongs to the thioredoxin family
SACN8_RS07095	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SACN8_RS07095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SACN8_RS07105	COG0535	radical SAM domain protein
SACN8_RS07110	COG4974	Belongs to the 'phage' integrase family
SACN8_RS07130	COG4962	Type ii secretion system protein e
SACN8_RS07155	COG0463	Glycosyl transferase, family 2
SACN8_RS07160	COG1201	RNA secondary structure unwinding
SACN8_RS07165	COG0617	tRNA 3'-terminal CCA addition
SACN8_RS07165	COG0517	IMP dehydrogenase activity
SACN8_RS07165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SACN8_RS07190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SACN8_RS07195	COG1058	Belongs to the CinA family
SACN8_RS07195	COG1546	Belongs to the CinA family
SACN8_RS07205	COG0072	phenylalanine-tRNA ligase activity
SACN8_RS07215	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SACN8_RS07220	COG0024	Methionine aminopeptidase
SACN8_RS07245	COG0561	phosphatase activity
SACN8_RS07260	COG2814	Major facilitator Superfamily
SACN8_RS07325	COG0417	DNA replication proofreading
SACN8_RS07355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SACN8_RS07375	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SACN8_RS07410	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SACN8_RS07415	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SACN8_RS07430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SACN8_RS07440	COG0028	Belongs to the TPP enzyme family
SACN8_RS07450	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SACN8_RS07460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SACN8_RS07475	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SACN8_RS07485	COG0037	tRNA processing
SACN8_RS07490	COG2096	Adenosyltransferase
SACN8_RS07495	COG0495	leucyl-tRNA aminoacylation
SACN8_RS07505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SACN8_RS07510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SACN8_RS07515	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SACN8_RS07520	COG0131	Imidazoleglycerol-phosphate dehydratase
SACN8_RS07525	COG0107	imidazoleglycerol-phosphate synthase activity
SACN8_RS07530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SACN8_RS07535	COG0140	phosphoribosyl-ATP diphosphatase activity
SACN8_RS07535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SACN8_RS07540	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SACN8_RS07550	COG2151	metal-sulfur cluster biosynthetic enzyme
SACN8_RS07555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SACN8_RS07560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SACN8_RS07575	COG1522	sequence-specific DNA binding
SACN8_RS07595	COG0167	dihydroorotate dehydrogenase activity
SACN8_RS07600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SACN8_RS07610	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
SACN8_RS07615	COG0540	Belongs to the ATCase OTCase family
SACN8_RS07620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SACN8_RS07625	COG0284	orotidine-5'-phosphate decarboxylase activity
SACN8_RS07655	COG0602	queuosine metabolic process
SACN8_RS07660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SACN8_RS07665	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SACN8_RS07665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SACN8_RS07670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SACN8_RS07680	COG0047	phosphoribosylformylglycinamidine synthase activity
SACN8_RS07685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SACN8_RS07690	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SACN8_RS07695	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SACN8_RS07700	COG0151	Belongs to the GarS family
SACN8_RS07705	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SACN8_RS07720	COG0137	argininosuccinate synthase activity
SACN8_RS07725	COG0165	Argininosuccinate lyase
SACN8_RS07730	COG0505	Belongs to the CarA family
SACN8_RS07735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SACN8_RS07740	COG0189	ligase activity
SACN8_RS07750	COG1250	3-hydroxyacyl-CoA dehydrogenase
SACN8_RS07790	COG1024	Enoyl-CoA hydratase
SACN8_RS07800	COG0109	protoheme IX farnesyltransferase activity
SACN8_RS07800	COG1612	heme a metabolic process
SACN8_RS07805	COG0460	homoserine dehydrogenase
SACN8_RS07815	COG0312	modulator of DNA gyrase
SACN8_RS07820	COG0312	modulator of DNA gyrase
SACN8_RS07825	COG0589	response to stress
SACN8_RS07835	COG0009	L-threonylcarbamoyladenylate synthase
SACN8_RS07840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SACN8_RS07860	COG0469	pyruvate kinase activity
SACN8_RS07875	COG2226	methyltransferase
SACN8_RS07890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SACN8_RS07905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SACN8_RS07925	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SACN8_RS07940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SACN8_RS07955	COG1139	Iron-sulfur cluster binding protein
SACN8_RS07965	COG0477	Major facilitator Superfamily
SACN8_RS07970	COG1846	Transcriptional regulator
SACN8_RS07990	COG3386	PFAM SMP-30 Gluconolaconase
SACN8_RS08015	COG1506	peptidase
SACN8_RS08015	COG0823	Involved in the tonB-independent uptake of proteins
SACN8_RS08015	COG4946	Tricorn protease homolog
SACN8_RS08070	COG0604	alcohol dehydrogenase
SACN8_RS08115	COG1131	(ABC) transporter
SACN8_RS08120	COG1012	belongs to the aldehyde dehydrogenase family
SACN8_RS08125	COG2252	PERMEase
SACN8_RS08130	COG0446	pyridine nucleotide-disulphide oxidoreductase
SACN8_RS08160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SACN8_RS08210	COG0412	Dienelactone hydrolase
SACN8_RS08240	COG2814	Major facilitator Superfamily
SACN8_RS08270	COG0477	Major facilitator Superfamily
SACN8_RS08285	COG1562	ergosterol biosynthetic process
SACN8_RS08305	COG1012	belongs to the aldehyde dehydrogenase family
SACN8_RS08400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SACN8_RS08425	COG0601	transmembrane transport
SACN8_RS08430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SACN8_RS08435	COG0444	Belongs to the ABC transporter superfamily
SACN8_RS08450	COG0179	Fumarylacetoacetate (FAA) hydrolase
SACN8_RS08455	COG2226	methyltransferase
SACN8_RS08455	COG1073	alpha beta
SACN8_RS08460	COG3511	phospholipase C
SACN8_RS08475	COG1024	Enoyl-CoA hydratase
SACN8_RS08505	COG1960	acyl-CoA dehydrogenase activity
SACN8_RS08510	COG0318	PFAM AMP-dependent synthetase and ligase
SACN8_RS08515	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SACN8_RS08525	COG2271	Major facilitator Superfamily
SACN8_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
SACN8_RS08615	COG4555	ABC transporter
SACN8_RS08655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SACN8_RS08665	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SACN8_RS08690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SACN8_RS08705	COG3387	PFAM Glycoside hydrolase 15-related
SACN8_RS08760	COG0438	transferase activity, transferring glycosyl groups
SACN8_RS08775	COG0596	Alpha beta hydrolase
SACN8_RS08800	COG0477	Major facilitator Superfamily
SACN8_RS08805	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SACN8_RS08810	COG0436	Aminotransferase
SACN8_RS08820	COG0471	metal ion transport
SACN8_RS08820	COG0490	domain, Protein
SACN8_RS08830	COG0475	glutathione-regulated potassium exporter activity
SACN8_RS08865	COG0477	Major facilitator Superfamily
SACN8_RS08880	COG1725	Transcriptional regulator
SACN8_RS08920	COG1012	belongs to the aldehyde dehydrogenase family
SACN8_RS08940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SACN8_RS08990	COG2815	serine threonine protein kinase
SACN8_RS08990	COG0515	serine threonine protein kinase
SACN8_RS09185	COG0438	transferase activity, transferring glycosyl groups
SACN8_RS09225	COG1215	transferase activity, transferring glycosyl groups
SACN8_RS09265	COG0297	glycogen (starch) synthase activity
SACN8_RS09285	COG0175	sulfate reduction
SACN8_RS09295	COG1215	transferase activity, transferring glycosyl groups
SACN8_RS09335	COG0028	Belongs to the TPP enzyme family
SACN8_RS09355	COG0179	Fumarylacetoacetate (FAA) hydrolase
SACN8_RS09370	COG2267	carboxylic ester hydrolase activity
SACN8_RS09380	COG2814	Major facilitator Superfamily
SACN8_RS09385	COG1584	GPR1 FUN34 yaaH family protein
SACN8_RS09445	COG2002	toxin-antitoxin pair type II binding
SACN8_RS09455	COG2814	Major facilitator Superfamily
SACN8_RS09475	COG1129	ABC transporter
SACN8_RS09495	COG1028	Short-chain dehydrogenase reductase Sdr
SACN8_RS09500	COG0318	PFAM AMP-dependent synthetase and ligase
SACN8_RS09530	COG2409	Drug exporters of the RND superfamily
SACN8_RS09545	COG0863	Belongs to the N(4) N(6)-methyltransferase family
SACN8_RS09620	COG1401	restriction endodeoxyribonuclease activity
SACN8_RS09630	COG1373	ATPase (AAA superfamily
SACN8_RS09665	COG1131	(ABC) transporter
SACN8_RS09725	COG1518	maintenance of DNA repeat elements
SACN8_RS09745	COG2062	phosphohistidine phosphatase, SixA
SACN8_RS09755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SACN8_RS09760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SACN8_RS09805	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SACN8_RS09825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SACN8_RS09845	COG2124	cytochrome p450
SACN8_RS09855	COG1335	isochorismatase
SACN8_RS09860	COG2814	Major facilitator Superfamily
SACN8_RS09865	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SACN8_RS09870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SACN8_RS09905	COG2271	Major facilitator Superfamily
SACN8_RS09940	COG0437	4 iron, 4 sulfur cluster binding
SACN8_RS09945	COG0243	molybdopterin cofactor binding
SACN8_RS09990	COG2814	Major facilitator Superfamily
SACN8_RS09995	COG1846	Transcriptional regulator
SACN8_RS10040	COG1172	Belongs to the binding-protein-dependent transport system permease family
SACN8_RS10050	COG1132	(ABC) transporter
SACN8_RS10070	COG0477	Major facilitator Superfamily
SACN8_RS10085	COG1028	Short-chain dehydrogenase reductase Sdr
SACN8_RS10090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SACN8_RS10095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SACN8_RS10115	COG1522	sequence-specific DNA binding
SACN8_RS10140	COG0174	glutamine synthetase
SACN8_RS10155	COG0492	ferredoxin-NADP+ reductase activity
SACN8_RS10160	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SACN8_RS10175	COG0318	PFAM AMP-dependent synthetase and ligase
SACN8_RS10200	COG2153	protein acetylation
SACN8_RS10205	COG0281	malic enzyme
SACN8_RS10250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SACN8_RS10270	COG0154	amidase activity
SACN8_RS10325	COG0531	amino acid
SACN8_RS10345	COG2017	converts alpha-aldose to the beta-anomer
SACN8_RS10365	COG0531	amino acid
SACN8_RS10370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SACN8_RS10375	COG2224	Isocitrate lyase
SACN8_RS10410	COG2897	thiosulfate sulfurtransferase activity
SACN8_RS10425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SACN8_RS10430	COG0175	sulfate reduction
SACN8_RS10435	COG2046	Belongs to the sulfate adenylyltransferase family
SACN8_RS10450	COG0095	Lipoate-protein ligase
SACN8_RS10455	COG0318	PFAM AMP-dependent synthetase and ligase
SACN8_RS10460	COG1250	3-hydroxyacyl-CoA dehydrogenase
SACN8_RS10475	COG0318	PFAM AMP-dependent synthetase and ligase
SACN8_RS10485	COG0596	Alpha beta hydrolase
SACN8_RS10505	COG1960	acyl-CoA dehydrogenase activity
SACN8_RS10510	COG1250	3-hydroxyacyl-CoA dehydrogenase
SACN8_RS10540	COG0318	PFAM AMP-dependent synthetase and ligase
SACN8_RS10550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SACN8_RS10575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SACN8_RS10585	COG1960	acyl-CoA dehydrogenase activity
SACN8_RS10590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SACN8_RS10660	COG0437	4 iron, 4 sulfur cluster binding
SACN8_RS10675	COG0674	pyruvate-flavodoxin oxidoreductase activity
SACN8_RS10680	COG1013	pyruvate-flavodoxin oxidoreductase activity
SACN8_RS10685	COG0656	L-ascorbic acid biosynthetic process
SACN8_RS10690	COG0028	Belongs to the TPP enzyme family
SACN8_RS10715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SACN8_RS10730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SACN8_RS10775	COG1592	Rubrerythrin
SACN8_RS10790	COG0598	Magnesium transport protein CorA
SACN8_RS10805	COG0693	protein deglycase activity
SACN8_RS10825	COG0477	Major facilitator Superfamily
SACN8_RS10840	COG1024	Enoyl-CoA hydratase
SACN8_RS10865	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SACN8_RS10885	COG2368	4-hydroxyphenylacetate
SACN8_RS10900	COG1741	Belongs to the pirin family
SACN8_RS10905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SACN8_RS10910	COG2154	pterin-4-alpha-carbinolamine dehydratase
SACN8_RS10920	COG4946	Tricorn protease homolog
SACN8_RS10920	COG0793	Belongs to the peptidase S41A family
SACN8_RS10945	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SACN8_RS10945	COG0674	pyruvate-flavodoxin oxidoreductase activity
SACN8_RS10950	COG1013	pyruvate-flavodoxin oxidoreductase activity
SACN8_RS10975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SACN8_RS10975	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SACN8_RS10980	COG1733	regulation of RNA biosynthetic process
SACN8_RS11015	COG0069	glutamate synthase activity
SACN8_RS11020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SACN8_RS11040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SACN8_RS11045	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SACN8_RS11085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SACN8_RS11085	COG0301	tRNA thio-modification
SACN8_RS11090	COG1260	myo-inositol-1-phosphate synthase
SACN8_RS11095	COG1007	ATP synthesis coupled electron transport
SACN8_RS11100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SACN8_RS11115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SACN8_RS11120	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SACN8_RS11125	COG0649	NAD binding
SACN8_RS11130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SACN8_RS11140	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SACN8_RS11210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SACN8_RS11215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SACN8_RS11220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SACN8_RS11230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SACN8_RS11260	COG2096	Adenosyltransferase
SACN8_RS11270	COG0538	isocitrate dehydrogenase activity