locus-tag	class	description
B6A18_RS00035	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B6A18_RS00035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6A18_RS00040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B6A18_RS00055	COG3253	May function as heme-dependent peroxidase
B6A18_RS00060	COG0494	nUDIX hydrolase
B6A18_RS00085	COG1011	Hydrolase
B6A18_RS00095	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B6A18_RS00105	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B6A18_RS00115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6A18_RS00135	COG0492	ferredoxin-NADP+ reductase activity
B6A18_RS00180	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
B6A18_RS00190	COG3118	belongs to the thioredoxin family
B6A18_RS00205	COG0516	GMP reductase activity
B6A18_RS00205	COG0517	IMP dehydrogenase activity
B6A18_RS00220	COG1957	nucleoside hydrolase
B6A18_RS00265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B6A18_RS00265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B6A18_RS00275	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
B6A18_RS00290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6A18_RS00315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6A18_RS00350	COG0417	DNA replication proofreading
B6A18_RS00360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B6A18_RS00380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B6A18_RS00385	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B6A18_RS00390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B6A18_RS00400	COG0200	Binds to the 23S rRNA
B6A18_RS00410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B6A18_RS00420	COG0052	Belongs to the universal ribosomal protein uS2 family
B6A18_RS00425	COG1355	regulation of microtubule-based process
B6A18_RS00435	COG1304	FMN binding
B6A18_RS00440	COG0142	geranyltranstransferase activity
B6A18_RS00445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6A18_RS00465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6A18_RS00505	COG0746	molybdenum cofactor guanylyltransferase activity
B6A18_RS00510	COG0303	'Molybdopterin
B6A18_RS00515	COG1763	Mo-molybdopterin cofactor biosynthetic process
B6A18_RS00520	COG2226	methyltransferase
B6A18_RS00540	COG1321	iron dependent repressor
B6A18_RS00545	COG2379	hydroxypyruvate reductase
B6A18_RS00555	COG4208	sulfate ABC transporter
B6A18_RS00565	COG0149	triose-phosphate isomerase activity
B6A18_RS00590	COG0114	fumarate hydratase activity
B6A18_RS00595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6A18_RS00610	COG1444	tRNA N-acetyltransferase activity
B6A18_RS00620	COG0708	Exodeoxyribonuclease III
B6A18_RS00650	COG0667	Aldo Keto reductase
B6A18_RS00660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B6A18_RS00685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B6A18_RS00695	COG1607	acyl-coa hydrolase
B6A18_RS00715	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6A18_RS00720	COG2222	sugar isomerase
B6A18_RS00725	COG0215	cysteine-tRNA ligase activity
B6A18_RS00740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B6A18_RS00750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6A18_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
B6A18_RS00760	COG1573	uracil-dna glycosylase
B6A18_RS00775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6A18_RS00800	COG1832	CoA-binding protein
B6A18_RS00830	COG0539	negative regulation of cytoplasmic translation
B6A18_RS00830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B6A18_RS00830	COG1185	polyribonucleotide nucleotidyltransferase activity
B6A18_RS00860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B6A18_RS00865	COG3959	Transketolase, thiamine diphosphate binding domain
B6A18_RS00870	COG3958	Transketolase
B6A18_RS00875	COG1605	Chorismate mutase
B6A18_RS00875	COG0077	Prephenate dehydratase
B6A18_RS00880	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B6A18_RS00885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B6A18_RS00890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B6A18_RS00895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6A18_RS00900	COG0083	homoserine kinase activity
B6A18_RS00905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6A18_RS00925	COG1199	ATP-dependent helicase activity
B6A18_RS00945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6A18_RS00955	COG1331	Highly conserved protein containing a thioredoxin domain
B6A18_RS00960	COG1028	Short-chain dehydrogenase reductase Sdr
B6A18_RS00965	COG0792	nuclease activity
B6A18_RS00985	COG1192	Involved in chromosome partitioning
B6A18_RS00995	COG0277	FAD linked oxidase domain protein
B6A18_RS01005	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6A18_RS01010	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B6A18_RS01010	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6A18_RS01035	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B6A18_RS01090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6A18_RS01100	COG1012	belongs to the aldehyde dehydrogenase family
B6A18_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
B6A18_RS01160	COG1011	Hydrolase
B6A18_RS01165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6A18_RS01190	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B6A18_RS01195	COG2079	MmgE PrpD family protein
B6A18_RS01200	COG0039	L-malate dehydrogenase activity
B6A18_RS01220	COG0778	Nitroreductase
B6A18_RS01230	COG0066	3-isopropylmalate dehydratase activity
B6A18_RS01235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B6A18_RS01240	COG0805	protein transport
B6A18_RS01250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6A18_RS01255	COG1116	anion transmembrane transporter activity
B6A18_RS01255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B6A18_RS01265	COG0439	Biotin carboxylase
B6A18_RS01275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6A18_RS01325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6A18_RS01330	COG0352	thiamine-phosphate diphosphorylase activity
B6A18_RS01330	COG0351	phosphomethylpyrimidine kinase
B6A18_RS01340	COG1215	transferase activity, transferring glycosyl groups
B6A18_RS01365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B6A18_RS01370	COG1205	dead DEAH box helicase
B6A18_RS01370	COG1111	helicase
B6A18_RS01405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B6A18_RS01405	COG0517	IMP dehydrogenase activity
B6A18_RS01405	COG0617	tRNA 3'-terminal CCA addition
B6A18_RS01425	COG0644	oxidoreductase
B6A18_RS01435	COG0058	SHG alpha-glucan phosphorylase activity
B6A18_RS01445	COG0535	radical SAM domain protein
B6A18_RS01460	COG0277	FAD linked oxidase domain protein
B6A18_RS01465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B6A18_RS01495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6A18_RS01510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B6A18_RS01515	COG0095	Lipoate-protein ligase
B6A18_RS01525	COG2301	Belongs to the HpcH HpaI aldolase family
B6A18_RS01530	COG2050	protein possibly involved in aromatic compounds catabolism
B6A18_RS01530	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B6A18_RS01540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B6A18_RS01545	COG0644	oxidoreductase
B6A18_RS01555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B6A18_RS01565	COG3383	formate dehydrogenase (NAD+) activity
B6A18_RS01585	COG0730	response to heat
B6A18_RS01590	COG2048	Heterodisulfide reductase, subunit B
B6A18_RS01605	COG0492	ferredoxin-NADP+ reductase activity
B6A18_RS01640	COG0425	Belongs to the sulfur carrier protein TusA family
B6A18_RS01645	COG2210	Belongs to the sulfur carrier protein TusA family
B6A18_RS01655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6A18_RS01690	COG0095	Lipoate-protein ligase
B6A18_RS01705	COG0509	glycine decarboxylation via glycine cleavage system
B6A18_RS01710	COG0509	glycine decarboxylation via glycine cleavage system
B6A18_RS01715	COG0095	Lipoate-protein ligase
B6A18_RS01765	COG0154	amidase activity
B6A18_RS01775	COG0243	molybdopterin cofactor binding
B6A18_RS01780	COG0475	glutathione-regulated potassium exporter activity
B6A18_RS01790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B6A18_RS01810	COG4106	trans-aconitate 2-methyltransferase activity
B6A18_RS01825	COG0495	leucyl-tRNA aminoacylation
B6A18_RS01835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6A18_RS01850	COG0037	tRNA processing
B6A18_RS01860	COG1489	DNA binding
B6A18_RS01865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B6A18_RS02005	COG1063	alcohol dehydrogenase
B6A18_RS02025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B6A18_RS02025	COG0519	Catalyzes the synthesis of GMP from XMP
B6A18_RS02030	COG0501	Belongs to the peptidase M48B family
B6A18_RS02035	COG0517	IMP dehydrogenase activity
B6A18_RS02035	COG0516	GMP reductase activity
B6A18_RS02050	COG1830	Aldolase
B6A18_RS02060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6A18_RS02075	COG0405	Gamma-glutamyltransferase
B6A18_RS02115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6A18_RS02140	COG1994	Peptidase M50
B6A18_RS02150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B6A18_RS02155	COG0489	protein tyrosine kinase activity
B6A18_RS02205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6A18_RS02700	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B6A18_RS02735	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B6A18_RS02750	COG1335	isochorismatase
B6A18_RS02755	COG1515	deoxyribonuclease V activity
B6A18_RS02765	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
B6A18_RS02770	COG0157	Belongs to the NadC ModD family
B6A18_RS02775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B6A18_RS02775	COG0519	Catalyzes the synthesis of GMP from XMP
B6A18_RS02780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B6A18_RS02790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6A18_RS02795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6A18_RS02800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6A18_RS02810	COG0430	RNA-3'-phosphate cyclase activity
B6A18_RS02865	COG0563	adenylate kinase activity
B6A18_RS02890	COG0200	Binds to the 23S rRNA
B6A18_RS02920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B6A18_RS02925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B6A18_RS02935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6A18_RS02945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B6A18_RS02950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B6A18_RS02955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B6A18_RS02965	COG0255	Belongs to the universal ribosomal protein uL29 family
B6A18_RS02970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B6A18_RS02980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B6A18_RS02985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6A18_RS02990	COG0089	rRNA binding
B6A18_RS03000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B6A18_RS03015	COG0473	3-isopropylmalate dehydrogenase activity
B6A18_RS03025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6A18_RS03030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6A18_RS03065	COG1185	polyribonucleotide nucleotidyltransferase activity
B6A18_RS03105	COG0012	GTP binding
B6A18_RS03110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B6A18_RS03125	COG2264	protein methyltransferase activity
B6A18_RS03130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6A18_RS03185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B6A18_RS03210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B6A18_RS03220	COG1047	Peptidyl-prolyl cis-trans
B6A18_RS03230	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B6A18_RS03245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B6A18_RS03285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6A18_RS03295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6A18_RS03330	COG0124	histidyl-tRNA synthetase
B6A18_RS03345	COG0459	protein refolding
B6A18_RS03370	COG1980	fructose-bisphosphate aldolase activity
B6A18_RS03375	COG1120	ATPase activity
B6A18_RS03385	COG0477	Major facilitator Superfamily
B6A18_RS03420	COG0051	transcription antitermination factor activity, RNA binding
B6A18_RS03425	COG0529	Catalyzes the synthesis of activated sulfate
B6A18_RS03425	COG2895	sulfate adenylyltransferase (ATP) activity
B6A18_RS03430	COG0049	tRNA binding
B6A18_RS03455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6A18_RS03465	COG0085	RNA polymerase activity
B6A18_RS03480	COG0105	UTP biosynthetic process
B6A18_RS03495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B6A18_RS03500	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6A18_RS03505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6A18_RS03515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6A18_RS03530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B6A18_RS03545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B6A18_RS03555	COG1522	sequence-specific DNA binding
B6A18_RS03565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B6A18_RS03585	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6A18_RS03585	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B6A18_RS03600	COG1056	cytidyltransferase-related domain
B6A18_RS03600	COG1051	belongs to the nudix hydrolase family
B6A18_RS03645	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B6A18_RS03680	COG1131	(ABC) transporter
B6A18_RS03750	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B6A18_RS03750	COG0517	IMP dehydrogenase activity
B6A18_RS03765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B6A18_RS03770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B6A18_RS03785	COG0189	ligase activity
B6A18_RS03790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6A18_RS03795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6A18_RS03800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6A18_RS03825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6A18_RS03835	COG0028	Belongs to the TPP enzyme family
B6A18_RS03860	COG0017	Asparaginyl-tRNA synthetase
B6A18_RS03885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6A18_RS03895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6A18_RS03895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6A18_RS03900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6A18_RS03900	COG1648	precorrin-2 dehydrogenase activity
B6A18_RS03905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B6A18_RS03910	COG0113	porphobilinogen synthase activity
B6A18_RS03915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6A18_RS03920	COG0181	hydroxymethylbilane synthase activity
B6A18_RS03945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6A18_RS03955	COG1793	dna ligase
B6A18_RS03960	COG0717	Belongs to the dCTP deaminase family
B6A18_RS03975	COG2078	PFAM AMMECR1 domain protein
B6A18_RS04005	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
B6A18_RS04020	COG0504	CTP synthase activity
B6A18_RS04025	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B6A18_RS04045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6A18_RS04065	COG2813	Specifically methylates the guanine in position
B6A18_RS04070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6A18_RS04075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6A18_RS04085	COG1201	RNA secondary structure unwinding
B6A18_RS04115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6A18_RS04125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6A18_RS04125	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6A18_RS04140	COG1797	cobyrinic acid a,c-diamide synthase activity
B6A18_RS04150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B6A18_RS04155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B6A18_RS04175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B6A18_RS04185	COG0539	negative regulation of cytoplasmic translation
B6A18_RS04200	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
B6A18_RS04205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6A18_RS04210	COG1110	DNA topoisomerase II activity
B6A18_RS04255	COG0667	Aldo Keto reductase
B6A18_RS04260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6A18_RS04270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6A18_RS04285	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
B6A18_RS04295	COG0163	prenyltransferase activity
B6A18_RS04325	COG0423	glycine-tRNA ligase activity
B6A18_RS04340	COG0023	Translation Initiation Factor
B6A18_RS04370	COG0501	Belongs to the peptidase M48B family
B6A18_RS04395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6A18_RS04425	COG0004	ammonium transporteR
B6A18_RS04435	COG4948	Mandelate Racemase Muconate Lactonizing
B6A18_RS04440	COG2271	Major facilitator Superfamily
B6A18_RS04445	COG0589	response to stress
B6A18_RS04450	COG0402	S-adenosylhomocysteine deaminase activity
B6A18_RS04535	COG0315	cyclic pyranopterin monophosphate synthase activity
B6A18_RS04540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6A18_RS04550	COG1881	PFAM PEBP family protein
B6A18_RS04555	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B6A18_RS04560	COG0154	amidase activity
B6A18_RS04565	COG1063	alcohol dehydrogenase
B6A18_RS04580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6A18_RS04580	COG1648	precorrin-2 dehydrogenase activity
B6A18_RS04600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6A18_RS04620	COG0071	Belongs to the small heat shock protein (HSP20) family
B6A18_RS04625	COG0346	lactoylglutathione lyase activity
B6A18_RS04630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6A18_RS04630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6A18_RS04650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6A18_RS04660	COG0492	ferredoxin-NADP+ reductase activity
B6A18_RS04675	COG0720	synthase
B6A18_RS04705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6A18_RS04710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B6A18_RS04735	COG1131	(ABC) transporter
B6A18_RS04770	COG0351	phosphomethylpyrimidine kinase
B6A18_RS04780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B6A18_RS04815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6A18_RS04820	COG0183	Belongs to the thiolase family
B6A18_RS04865	COG0083	homoserine kinase activity
B6A18_RS04870	COG0303	'Molybdopterin
B6A18_RS04885	COG0714	Associated with various cellular activities
B6A18_RS04890	COG2304	oxidoreductase activity
B6A18_RS04910	COG1053	succinate dehydrogenase
B6A18_RS04915	COG0647	UMP catabolic process
B6A18_RS04930	COG0644	oxidoreductase
B6A18_RS04960	COG1522	sequence-specific DNA binding
B6A18_RS04965	COG0189	ligase activity
B6A18_RS04970	COG0142	geranyltranstransferase activity
B6A18_RS04980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B6A18_RS04985	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B6A18_RS05025	COG1131	(ABC) transporter
B6A18_RS05045	COG0463	Glycosyl transferase, family 2
B6A18_RS05065	COG0006	proline dipeptidase activity
B6A18_RS05070	COG0123	including yeast histone deacetylase and acetoin utilization protein
B6A18_RS05095	COG3608	succinylglutamate desuccinylase aspartoacylase
B6A18_RS05095	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B6A18_RS05105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B6A18_RS05110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6A18_RS05115	COG0671	phosphoesterase, PA-phosphatase related
B6A18_RS05125	COG1131	(ABC) transporter
B6A18_RS05130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6A18_RS05140	COG2226	methyltransferase
B6A18_RS05150	COG0537	adenosine 5'-monophosphoramidase activity
B6A18_RS05160	COG4608	Belongs to the ABC transporter superfamily
B6A18_RS05165	COG0444	Belongs to the ABC transporter superfamily
B6A18_RS05170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6A18_RS05175	COG0601	transmembrane transport
B6A18_RS05200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6A18_RS05210	COG2814	Major facilitator Superfamily
B6A18_RS05245	COG4274	PFAM GYD family protein
B6A18_RS05255	COG0318	PFAM AMP-dependent synthetase and ligase
B6A18_RS05265	COG0076	glutamate decarboxylase activity
B6A18_RS05270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6A18_RS05275	COG2223	nitrite transmembrane transporter activity
B6A18_RS05325	COG1960	acyl-CoA dehydrogenase activity
B6A18_RS05335	COG1960	acyl-CoA dehydrogenase activity
B6A18_RS05340	COG0402	S-adenosylhomocysteine deaminase activity
B6A18_RS05370	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6A18_RS05390	COG0318	PFAM AMP-dependent synthetase and ligase
B6A18_RS05395	COG1607	acyl-coa hydrolase
B6A18_RS05425	COG2149	membrane
B6A18_RS05430	COG0697	spore germination
B6A18_RS05460	COG1012	belongs to the aldehyde dehydrogenase family
B6A18_RS05470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B6A18_RS05475	COG1028	Short-chain dehydrogenase reductase Sdr
B6A18_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
B6A18_RS05500	COG1309	transcriptional regulator
B6A18_RS05505	COG1960	acyl-CoA dehydrogenase activity
B6A18_RS05510	COG1024	Enoyl-CoA hydratase
B6A18_RS05515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6A18_RS05520	COG0318	PFAM AMP-dependent synthetase and ligase
B6A18_RS05525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6A18_RS05530	COG1960	acyl-CoA dehydrogenase activity
B6A18_RS05535	COG0183	Belongs to the thiolase family
B6A18_RS05540	COG1063	alcohol dehydrogenase
B6A18_RS05545	COG0657	acetylesterase activity
B6A18_RS05555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B6A18_RS05575	COG0318	PFAM AMP-dependent synthetase and ligase
B6A18_RS05580	COG1960	acyl-CoA dehydrogenase activity
B6A18_RS05590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B6A18_RS05595	COG0318	PFAM AMP-dependent synthetase and ligase
B6A18_RS05635	COG0442	prolyl-tRNA aminoacylation
B6A18_RS05665	COG3384	dioxygenase
B6A18_RS05690	COG0028	Belongs to the TPP enzyme family
B6A18_RS05700	COG1024	Enoyl-CoA hydratase
B6A18_RS05715	COG3511	phospholipase C
B6A18_RS05735	COG0531	amino acid
B6A18_RS05770	COG1175	transmembrane transport
B6A18_RS05780	COG3842	ATPase activity
B6A18_RS05785	COG0517	IMP dehydrogenase activity
B6A18_RS05785	COG0617	tRNA 3'-terminal CCA addition
B6A18_RS05785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B6A18_RS05795	COG3634	alkyl hydroperoxide reductase activity
B6A18_RS05800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6A18_RS05820	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
B6A18_RS05855	COG0515	serine threonine protein kinase
B6A18_RS05860	COG2814	Major facilitator Superfamily
B6A18_RS05870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6A18_RS05890	COG0277	FAD linked oxidase domain protein
B6A18_RS05900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B6A18_RS05905	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B6A18_RS05915	COG0515	serine threonine protein kinase
B6A18_RS05915	COG2815	serine threonine protein kinase
B6A18_RS05920	COG0251	oxidation-reduction process
B6A18_RS05925	COG0517	IMP dehydrogenase activity
B6A18_RS05925	COG0516	GMP reductase activity
B6A18_RS05940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B6A18_RS05950	COG0297	glycogen (starch) synthase activity
B6A18_RS05955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B6A18_RS05980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B6A18_RS06010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B6A18_RS06045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6A18_RS06050	COG1121	(ABC) transporter
B6A18_RS06075	COG0415	Belongs to the DNA photolyase family
B6A18_RS06090	COG0351	phosphomethylpyrimidine kinase
B6A18_RS06090	COG0352	thiamine-phosphate diphosphorylase activity
B6A18_RS06090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B6A18_RS06100	COG1028	Short-chain dehydrogenase reductase Sdr
B6A18_RS06130	COG2860	membrane
B6A18_RS06175	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B6A18_RS06185	COG0438	transferase activity, transferring glycosyl groups
B6A18_RS06190	COG3387	PFAM Glycoside hydrolase 15-related
B6A18_RS06200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6A18_RS06200	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B6A18_RS06205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6A18_RS06240	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6A18_RS06245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6A18_RS06250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6A18_RS06265	COG0045	succinate-CoA ligase (ADP-forming) activity
B6A18_RS06325	COG1185	polyribonucleotide nucleotidyltransferase activity
B6A18_RS06360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6A18_RS06370	COG1234	tRNA 3'-trailer cleavage
B6A18_RS06385	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B6A18_RS06420	COG0300	oxidoreductase activity
B6A18_RS06435	COG4152	abc transporter atp-binding protein
B6A18_RS06460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B6A18_RS06475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6A18_RS06485	COG0528	UMP kinase activity
B6A18_RS06495	COG1028	Short-chain dehydrogenase reductase Sdr
B6A18_RS06505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6A18_RS06510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6A18_RS06540	COG1201	RNA secondary structure unwinding
B6A18_RS06550	COG1110	DNA topoisomerase II activity
B6A18_RS06585	COG1324	tolerance protein
B6A18_RS06595	COG0154	amidase activity
B6A18_RS06610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6A18_RS06610	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B6A18_RS06660	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
B6A18_RS06690	COG0252	asparaginase activity
B6A18_RS06695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6A18_RS06710	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6A18_RS06720	COG0126	phosphoglycerate kinase activity
B6A18_RS06730	COG0589	response to stress
B6A18_RS06735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6A18_RS06755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6A18_RS06760	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B6A18_RS06780	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
B6A18_RS06785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B6A18_RS06800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6A18_RS06805	COG1222	aaa ATPase
B6A18_RS06845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6A18_RS06850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6A18_RS06855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6A18_RS06860	COG0509	glycine decarboxylation via glycine cleavage system
B6A18_RS06880	COG0396	ATPase activity
B6A18_RS06905	COG0604	alcohol dehydrogenase
B6A18_RS06945	COG0459	protein refolding
B6A18_RS06980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6A18_RS06990	COG0587	DNA-directed DNA polymerase activity
B6A18_RS07000	COG0527	aspartate kinase activity
B6A18_RS07000	COG0460	homoserine dehydrogenase
B6A18_RS07025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6A18_RS07025	COG0574	Belongs to the PEP-utilizing enzyme family
B6A18_RS07040	COG1254	Belongs to the acylphosphatase family
B6A18_RS07045	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
B6A18_RS07055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B6A18_RS07060	COG0135	phosphoribosylanthranilate isomerase activity
B6A18_RS07065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6A18_RS07070	COG0512	Glutamine amidotransferase of anthranilate synthase
B6A18_RS07070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B6A18_RS07075	COG0134	indole-3-glycerol-phosphate synthase activity
B6A18_RS07080	COG0436	Aminotransferase
B6A18_RS07085	COG0525	valine-tRNA ligase activity
B6A18_RS07195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6A18_RS07205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B6A18_RS07210	COG0081	regulation of translation
B6A18_RS07215	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B6A18_RS07230	COG0552	protein localization to endoplasmic reticulum
B6A18_RS07280	COG2848	UPF0210 protein
B6A18_RS07295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6A18_RS07310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6A18_RS07315	COG0006	proline dipeptidase activity
B6A18_RS07320	COG0302	gtp cyclohydrolase
B6A18_RS07335	COG3842	ATPase activity
B6A18_RS07340	COG3118	belongs to the thioredoxin family
B6A18_RS07350	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B6A18_RS07350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6A18_RS07360	COG0535	radical SAM domain protein
B6A18_RS07365	COG4974	Belongs to the 'phage' integrase family
B6A18_RS07385	COG4962	Type ii secretion system protein e
B6A18_RS07415	COG0463	Glycosyl transferase, family 2
B6A18_RS07420	COG1201	RNA secondary structure unwinding
B6A18_RS07430	COG0617	tRNA 3'-terminal CCA addition
B6A18_RS07430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B6A18_RS07430	COG0517	IMP dehydrogenase activity
B6A18_RS07455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6A18_RS07460	COG1546	Belongs to the CinA family
B6A18_RS07460	COG1058	Belongs to the CinA family
B6A18_RS07470	COG0072	phenylalanine-tRNA ligase activity
B6A18_RS07480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B6A18_RS07485	COG0024	Methionine aminopeptidase
B6A18_RS07510	COG0561	phosphatase activity
B6A18_RS07525	COG2814	Major facilitator Superfamily
B6A18_RS07595	COG0417	DNA replication proofreading
B6A18_RS07625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6A18_RS07645	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
B6A18_RS07680	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B6A18_RS07685	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B6A18_RS07700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B6A18_RS07710	COG0028	Belongs to the TPP enzyme family
B6A18_RS07720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B6A18_RS07730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B6A18_RS07745	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B6A18_RS07755	COG0037	tRNA processing
B6A18_RS07760	COG2096	Adenosyltransferase
B6A18_RS07765	COG0495	leucyl-tRNA aminoacylation
B6A18_RS07775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6A18_RS07780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B6A18_RS07785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B6A18_RS07790	COG0131	Imidazoleglycerol-phosphate dehydratase
B6A18_RS07795	COG0107	imidazoleglycerol-phosphate synthase activity
B6A18_RS07800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B6A18_RS07805	COG0140	phosphoribosyl-ATP diphosphatase activity
B6A18_RS07805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B6A18_RS07810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B6A18_RS07820	COG2151	metal-sulfur cluster biosynthetic enzyme
B6A18_RS07825	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B6A18_RS07830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6A18_RS07845	COG1522	sequence-specific DNA binding
B6A18_RS07865	COG0167	dihydroorotate dehydrogenase activity
B6A18_RS07870	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6A18_RS07880	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B6A18_RS07885	COG0540	Belongs to the ATCase OTCase family
B6A18_RS07890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B6A18_RS07895	COG0284	orotidine-5'-phosphate decarboxylase activity
B6A18_RS07925	COG0602	queuosine metabolic process
B6A18_RS07930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6A18_RS07935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6A18_RS07935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6A18_RS07940	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6A18_RS07950	COG0047	phosphoribosylformylglycinamidine synthase activity
B6A18_RS07955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6A18_RS07960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B6A18_RS07965	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B6A18_RS07970	COG0151	Belongs to the GarS family
B6A18_RS07975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6A18_RS07990	COG0137	argininosuccinate synthase activity
B6A18_RS07995	COG0165	Argininosuccinate lyase
B6A18_RS08000	COG0505	Belongs to the CarA family
B6A18_RS08005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6A18_RS08010	COG0189	ligase activity
B6A18_RS08020	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6A18_RS08065	COG1024	Enoyl-CoA hydratase
B6A18_RS08075	COG0109	protoheme IX farnesyltransferase activity
B6A18_RS08075	COG1612	heme a metabolic process
B6A18_RS08080	COG0460	homoserine dehydrogenase
B6A18_RS08090	COG0312	modulator of DNA gyrase
B6A18_RS08095	COG0312	modulator of DNA gyrase
B6A18_RS08100	COG0589	response to stress
B6A18_RS08110	COG0009	L-threonylcarbamoyladenylate synthase
B6A18_RS08115	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6A18_RS08135	COG0469	pyruvate kinase activity
B6A18_RS08150	COG2226	methyltransferase
B6A18_RS08165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6A18_RS08180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B6A18_RS08200	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B6A18_RS08215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B6A18_RS08230	COG1139	Iron-sulfur cluster binding protein
B6A18_RS08240	COG0477	Major facilitator Superfamily
B6A18_RS08245	COG1846	Transcriptional regulator
B6A18_RS08265	COG3386	PFAM SMP-30 Gluconolaconase
B6A18_RS08290	COG1506	peptidase
B6A18_RS08290	COG4946	Tricorn protease homolog
B6A18_RS08290	COG0823	Involved in the tonB-independent uptake of proteins
B6A18_RS08350	COG0604	alcohol dehydrogenase
B6A18_RS08395	COG1131	(ABC) transporter
B6A18_RS08400	COG1012	belongs to the aldehyde dehydrogenase family
B6A18_RS08405	COG2252	PERMEase
B6A18_RS08410	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6A18_RS08440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6A18_RS08495	COG0412	Dienelactone hydrolase
B6A18_RS08525	COG2814	Major facilitator Superfamily
B6A18_RS08555	COG0477	Major facilitator Superfamily
B6A18_RS08570	COG1562	ergosterol biosynthetic process
B6A18_RS08590	COG1012	belongs to the aldehyde dehydrogenase family
B6A18_RS08715	COG0601	transmembrane transport
B6A18_RS08720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6A18_RS08725	COG0444	Belongs to the ABC transporter superfamily
B6A18_RS08740	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6A18_RS08745	COG2226	methyltransferase
B6A18_RS08745	COG1073	alpha beta
B6A18_RS08750	COG3511	phospholipase C
B6A18_RS08765	COG1024	Enoyl-CoA hydratase
B6A18_RS08795	COG1960	acyl-CoA dehydrogenase activity
B6A18_RS08800	COG0318	PFAM AMP-dependent synthetase and ligase
B6A18_RS08805	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B6A18_RS08815	COG2271	Major facilitator Superfamily
B6A18_RS08860	COG1028	Short-chain dehydrogenase reductase Sdr
B6A18_RS08905	COG4555	ABC transporter
B6A18_RS08945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6A18_RS08955	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B6A18_RS08980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6A18_RS08995	COG3387	PFAM Glycoside hydrolase 15-related
B6A18_RS09050	COG0438	transferase activity, transferring glycosyl groups
B6A18_RS09065	COG0596	Alpha beta hydrolase
B6A18_RS09095	COG0477	Major facilitator Superfamily
B6A18_RS09100	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B6A18_RS09105	COG0436	Aminotransferase
B6A18_RS09115	COG0490	domain, Protein
B6A18_RS09115	COG0471	metal ion transport
B6A18_RS09125	COG0475	glutathione-regulated potassium exporter activity
B6A18_RS09160	COG0477	Major facilitator Superfamily
B6A18_RS09175	COG1725	Transcriptional regulator
B6A18_RS09215	COG1012	belongs to the aldehyde dehydrogenase family
B6A18_RS09235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B6A18_RS09300	COG0028	Belongs to the TPP enzyme family
B6A18_RS09320	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6A18_RS09335	COG2267	carboxylic ester hydrolase activity
B6A18_RS09345	COG2814	Major facilitator Superfamily
B6A18_RS09350	COG1584	GPR1 FUN34 yaaH family protein
B6A18_RS09410	COG2002	toxin-antitoxin pair type II binding
B6A18_RS09420	COG2814	Major facilitator Superfamily
B6A18_RS09440	COG1129	ABC transporter
B6A18_RS09460	COG1028	Short-chain dehydrogenase reductase Sdr
B6A18_RS09465	COG0318	PFAM AMP-dependent synthetase and ligase
B6A18_RS09495	COG2409	Drug exporters of the RND superfamily
B6A18_RS09510	COG0863	Belongs to the N(4) N(6)-methyltransferase family
B6A18_RS09595	COG1401	restriction endodeoxyribonuclease activity
B6A18_RS09605	COG1373	ATPase (AAA superfamily
B6A18_RS09640	COG1131	(ABC) transporter
B6A18_RS09710	COG1518	maintenance of DNA repeat elements
B6A18_RS09730	COG2062	phosphohistidine phosphatase, SixA
B6A18_RS09740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6A18_RS09745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6A18_RS09790	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
B6A18_RS09815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B6A18_RS09825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6A18_RS09850	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B6A18_RS09940	COG0477	Major facilitator Superfamily
B6A18_RS09945	COG4638	Rieske (2fe-2S)
B6A18_RS09960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6A18_RS09995	COG2151	metal-sulfur cluster biosynthetic enzyme
B6A18_RS10015	COG1078	dGTPase activity
B6A18_RS10025	COG0477	Major facilitator Superfamily
B6A18_RS10050	COG2124	cytochrome p450
B6A18_RS10060	COG1335	isochorismatase
B6A18_RS10065	COG2814	Major facilitator Superfamily
B6A18_RS10075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B6A18_RS10080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6A18_RS10115	COG2271	Major facilitator Superfamily
B6A18_RS10145	COG0437	4 iron, 4 sulfur cluster binding
B6A18_RS10150	COG0243	molybdopterin cofactor binding
B6A18_RS10195	COG2814	Major facilitator Superfamily
B6A18_RS10200	COG1846	Transcriptional regulator
B6A18_RS10245	COG1172	Belongs to the binding-protein-dependent transport system permease family
B6A18_RS10410	COG0477	Major facilitator Superfamily
B6A18_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
B6A18_RS10430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6A18_RS10435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6A18_RS10455	COG1522	sequence-specific DNA binding
B6A18_RS10480	COG0174	glutamine synthetase
B6A18_RS10495	COG0492	ferredoxin-NADP+ reductase activity
B6A18_RS10500	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B6A18_RS10515	COG0318	PFAM AMP-dependent synthetase and ligase
B6A18_RS10540	COG2153	protein acetylation
B6A18_RS10545	COG0281	malic enzyme
B6A18_RS10590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6A18_RS10610	COG0154	amidase activity
B6A18_RS10635	COG1770	oligopeptidase
B6A18_RS10670	COG0531	amino acid
B6A18_RS10690	COG2017	converts alpha-aldose to the beta-anomer
B6A18_RS10710	COG0531	amino acid
B6A18_RS10715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B6A18_RS10720	COG2224	Isocitrate lyase
B6A18_RS10755	COG2897	thiosulfate sulfurtransferase activity
B6A18_RS10770	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6A18_RS10775	COG0175	sulfate reduction
B6A18_RS10780	COG2046	Belongs to the sulfate adenylyltransferase family
B6A18_RS10795	COG0095	Lipoate-protein ligase
B6A18_RS10800	COG0318	PFAM AMP-dependent synthetase and ligase
B6A18_RS10805	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6A18_RS10820	COG0318	PFAM AMP-dependent synthetase and ligase
B6A18_RS10830	COG0596	Alpha beta hydrolase
B6A18_RS10850	COG1960	acyl-CoA dehydrogenase activity
B6A18_RS10855	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6A18_RS10885	COG0318	PFAM AMP-dependent synthetase and ligase
B6A18_RS10895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B6A18_RS10920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6A18_RS10930	COG1960	acyl-CoA dehydrogenase activity
B6A18_RS10935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6A18_RS11005	COG0437	4 iron, 4 sulfur cluster binding
B6A18_RS11020	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6A18_RS11025	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6A18_RS11030	COG0656	L-ascorbic acid biosynthetic process
B6A18_RS11035	COG0028	Belongs to the TPP enzyme family
B6A18_RS11060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B6A18_RS11075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6A18_RS11120	COG1592	Rubrerythrin
B6A18_RS11135	COG0598	Magnesium transport protein CorA
B6A18_RS11150	COG0693	protein deglycase activity
B6A18_RS11170	COG0477	Major facilitator Superfamily
B6A18_RS11185	COG1024	Enoyl-CoA hydratase
B6A18_RS11210	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B6A18_RS11225	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6A18_RS11230	COG2368	4-hydroxyphenylacetate
B6A18_RS11245	COG1741	Belongs to the pirin family
B6A18_RS11250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6A18_RS11255	COG2154	pterin-4-alpha-carbinolamine dehydratase
B6A18_RS11265	COG4946	Tricorn protease homolog
B6A18_RS11265	COG0793	Belongs to the peptidase S41A family
B6A18_RS11290	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6A18_RS11290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B6A18_RS11295	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6A18_RS11320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6A18_RS11320	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B6A18_RS11325	COG1733	regulation of RNA biosynthetic process
B6A18_RS11360	COG0069	glutamate synthase activity
B6A18_RS11365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6A18_RS11385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6A18_RS11390	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B6A18_RS11430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B6A18_RS11430	COG0301	tRNA thio-modification
B6A18_RS11435	COG1260	myo-inositol-1-phosphate synthase
B6A18_RS11440	COG1007	ATP synthesis coupled electron transport
B6A18_RS11445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6A18_RS11460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6A18_RS11465	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B6A18_RS11470	COG0649	NAD binding
B6A18_RS11475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6A18_RS11485	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B6A18_RS11555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B6A18_RS11560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6A18_RS11565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6A18_RS11575	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B6A18_RS11605	COG2096	Adenosyltransferase
B6A18_RS11615	COG0538	isocitrate dehydrogenase activity