locus-tag	class	description
SIH_RS00020	COG2154	pterin-4-alpha-carbinolamine dehydratase
SIH_RS00100	COG1331	Highly conserved protein containing a thioredoxin domain
SIH_RS00110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SIH_RS00120	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SIH_RS00145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SIH_RS00160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIH_RS00170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SIH_RS00175	COG2814	Major facilitator Superfamily
SIH_RS00185	COG0492	ferredoxin-NADP+ reductase activity
SIH_RS00255	COG0588	phosphoglycerate mutase activity
SIH_RS00275	COG1957	nucleoside hydrolase
SIH_RS00325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SIH_RS00325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SIH_RS00330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SIH_RS00335	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
SIH_RS00355	COG0596	Alpha beta hydrolase
SIH_RS00370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SIH_RS00410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIH_RS00415	COG1573	uracil-dna glycosylase
SIH_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
SIH_RS00445	COG0215	cysteine-tRNA ligase activity
SIH_RS00450	COG2222	sugar isomerase
SIH_RS00460	COG0446	pyridine nucleotide-disulphide oxidoreductase
SIH_RS00470	COG0433	COG0433 Predicted ATPase
SIH_RS00480	COG1607	acyl-coa hydrolase
SIH_RS00490	COG1028	Short-chain dehydrogenase reductase Sdr
SIH_RS00495	COG0708	Exodeoxyribonuclease III
SIH_RS00500	COG0515	serine threonine protein kinase
SIH_RS00500	COG2815	serine threonine protein kinase
SIH_RS00535	COG1648	precorrin-2 dehydrogenase activity
SIH_RS00535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SIH_RS00545	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SIH_RS00575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIH_RS00585	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
SIH_RS00695	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SIH_RS00700	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SIH_RS00715	COG0189	ligase activity
SIH_RS00725	COG0493	'glutamate synthase
SIH_RS00755	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SIH_RS00775	COG1053	succinate dehydrogenase
SIH_RS00795	COG2304	oxidoreductase activity
SIH_RS00800	COG0714	Associated with various cellular activities
SIH_RS00825	COG0083	homoserine kinase activity
SIH_RS00830	COG0626	cystathionine gamma-synthase activity
SIH_RS00870	COG0183	Belongs to the thiolase family
SIH_RS00875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SIH_RS00915	COG1215	transferase activity, transferring glycosyl groups
SIH_RS00920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SIH_RS00930	COG0351	phosphomethylpyrimidine kinase
SIH_RS00935	COG0314	molybdopterin synthase activity
SIH_RS00960	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SIH_RS00970	COG1131	(ABC) transporter
SIH_RS01000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SIH_RS01005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SIH_RS01035	COG0720	synthase
SIH_RS01050	COG0492	ferredoxin-NADP+ reductase activity
SIH_RS01060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIH_RS01080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SIH_RS01080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SIH_RS01090	COG0071	Belongs to the small heat shock protein (HSP20) family
SIH_RS01150	COG0402	S-adenosylhomocysteine deaminase activity
SIH_RS01175	COG0430	RNA-3'-phosphate cyclase activity
SIH_RS01185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SIH_RS01190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SIH_RS01195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIH_RS01205	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SIH_RS01215	COG1515	deoxyribonuclease V activity
SIH_RS01220	COG1335	isochorismatase
SIH_RS01255	COG4581	dead DEAH box helicase
SIH_RS01265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SIH_RS01275	COG0439	Biotin carboxylase
SIH_RS01285	COG1116	anion transmembrane transporter activity
SIH_RS01295	COG0066	3-isopropylmalate dehydratase activity
SIH_RS01300	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SIH_RS01305	COG0415	Belongs to the DNA photolyase family
SIH_RS01340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SIH_RS01380	COG0045	succinate-CoA ligase (ADP-forming) activity
SIH_RS01395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SIH_RS01400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SIH_RS01430	COG0657	acetylesterase activity
SIH_RS01435	COG1063	alcohol dehydrogenase
SIH_RS01440	COG0183	Belongs to the thiolase family
SIH_RS01445	COG1960	acyl-CoA dehydrogenase activity
SIH_RS01450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SIH_RS01455	COG1028	Short-chain dehydrogenase reductase Sdr
SIH_RS01460	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SIH_RS01500	COG0318	PFAM AMP-dependent synthetase and ligase
SIH_RS01505	COG1960	acyl-CoA dehydrogenase activity
SIH_RS01510	COG1024	Enoyl-CoA hydratase
SIH_RS01515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIH_RS01520	COG2814	Major facilitator Superfamily
SIH_RS01520	COG0477	Major facilitator Superfamily
SIH_RS01555	COG0318	PFAM AMP-dependent synthetase and ligase
SIH_RS01565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SIH_RS01570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SIH_RS01665	COG0432	Pfam Uncharacterised protein family UPF0047
SIH_RS01670	COG1305	Transglutaminase-like
SIH_RS01685	COG1522	sequence-specific DNA binding
SIH_RS01690	COG1013	pyruvate-flavodoxin oxidoreductase activity
SIH_RS01695	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIH_RS01710	COG1620	l-lactate permease
SIH_RS01735	COG0450	alkyl hydroperoxide reductase
SIH_RS01780	COG3573	Dehydrogenase
SIH_RS01800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SIH_RS01805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SIH_RS01815	COG2062	phosphohistidine phosphatase, SixA
SIH_RS01825	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIH_RS01905	COG1473	amidohydrolase
SIH_RS01965	COG1373	ATPase (AAA superfamily
SIH_RS01995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SIH_RS02055	COG0277	FAD linked oxidase domain protein
SIH_RS02115	COG3350	monooxygenase activity
SIH_RS02140	COG2151	metal-sulfur cluster biosynthetic enzyme
SIH_RS02145	COG0028	Belongs to the TPP enzyme family
SIH_RS02215	COG1091	dTDP-4-dehydrorhamnose reductase activity
SIH_RS02220	COG3511	phospholipase C
SIH_RS02245	COG0438	transferase activity, transferring glycosyl groups
SIH_RS02270	COG1215	transferase activity, transferring glycosyl groups
SIH_RS02275	COG0438	transferase activity, transferring glycosyl groups
SIH_RS02280	COG0438	transferase activity, transferring glycosyl groups
SIH_RS02290	COG0438	transferase activity, transferring glycosyl groups
SIH_RS02335	COG1216	Glycosyl transferase, family 2
SIH_RS02370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SIH_RS02375	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SIH_RS02395	COG0463	Glycosyl transferase, family 2
SIH_RS02465	COG2224	Isocitrate lyase
SIH_RS02470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SIH_RS02490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIH_RS02495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SIH_RS02510	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SIH_RS02560	COG1131	(ABC) transporter
SIH_RS02580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIH_RS02640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SIH_RS02735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SIH_RS02740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SIH_RS02795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SIH_RS02810	COG1373	ATPase (AAA superfamily
SIH_RS02940	COG0535	radical SAM domain protein
SIH_RS02945	COG0535	radical SAM domain protein
SIH_RS02950	COG1012	belongs to the aldehyde dehydrogenase family
SIH_RS03010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIH_RS03055	COG0508	dehydrogenase complex catalyzes the overall conversion of
SIH_RS03060	COG3199	ATP-NAD kinase
SIH_RS03065	COG0022	dehydrogenase e1 component
SIH_RS03070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SIH_RS03075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIH_RS03115	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SIH_RS03150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SIH_RS03180	COG0598	Magnesium transport protein CorA
SIH_RS03205	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SIH_RS03205	COG2146	nitrite reductase [NAD(P)H] activity
SIH_RS03230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIH_RS03235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SIH_RS03240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIH_RS03285	COG1960	acyl-CoA dehydrogenase activity
SIH_RS03290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIH_RS03300	COG2271	Major facilitator Superfamily
SIH_RS03305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SIH_RS03315	COG2368	4-hydroxyphenylacetate
SIH_RS03355	COG0477	Major facilitator Superfamily
SIH_RS03380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SIH_RS03385	COG0531	amino acid
SIH_RS03390	COG1953	Uracil, thiamine, allantoin
SIH_RS03400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIH_RS03410	COG0477	Major facilitator Superfamily
SIH_RS03455	COG1011	Hydrolase
SIH_RS03525	COG1024	Enoyl-CoA hydratase
SIH_RS03535	COG0425	Belongs to the sulfur carrier protein TusA family
SIH_RS03570	COG1042	CoA-binding domain protein
SIH_RS03570	COG0045	succinate-CoA ligase (ADP-forming) activity
SIH_RS03570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SIH_RS03590	COG2226	methyltransferase
SIH_RS03625	COG0501	Belongs to the peptidase M48B family
SIH_RS03640	COG1968	undecaprenyl-diphosphatase activity
SIH_RS03645	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SIH_RS03660	COG0589	response to stress
SIH_RS03815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIH_RS03840	COG4638	Rieske (2fe-2S)
SIH_RS03870	COG0434	BtpA family
SIH_RS03950	COG1131	(ABC) transporter
SIH_RS04025	COG1518	maintenance of DNA repeat elements
SIH_RS04035	COG3547	Transposase (IS116 IS110 IS902 family)
SIH_RS04065	COG0179	Fumarylacetoacetate (FAA) hydrolase
SIH_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
SIH_RS04130	COG0477	Major facilitator Superfamily
SIH_RS04135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIH_RS04170	COG4948	Mandelate Racemase Muconate Lactonizing
SIH_RS04175	COG2814	Major facilitator Superfamily
SIH_RS04205	COG1953	Uracil, thiamine, allantoin
SIH_RS04275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIH_RS04375	COG2814	Major facilitator Superfamily
SIH_RS04390	COG0318	PFAM AMP-dependent synthetase and ligase
SIH_RS04395	COG1960	acyl-CoA dehydrogenase activity
SIH_RS04440	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SIH_RS04480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SIH_RS04485	COG0793	Belongs to the peptidase S41A family
SIH_RS04485	COG4946	Tricorn protease homolog
SIH_RS04530	COG0412	Dienelactone hydrolase
SIH_RS04580	COG0675	Transposase, IS605 OrfB family
SIH_RS04590	COG2084	Dehydrogenase
SIH_RS04625	COG1373	ATPase (AAA superfamily
SIH_RS04665	COG0298	carbon dioxide binding
SIH_RS04690	COG0298	carbon dioxide binding
SIH_RS04740	COG1733	regulation of RNA biosynthetic process
SIH_RS04825	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SIH_RS04830	COG1733	regulation of RNA biosynthetic process
SIH_RS04840	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SIH_RS04930	COG0455	bacterial-type flagellum organization
SIH_RS04950	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SIH_RS04950	COG2050	protein possibly involved in aromatic compounds catabolism
SIH_RS04955	COG2301	Belongs to the HpcH HpaI aldolase family
SIH_RS04960	COG1802	Transcriptional regulator
SIH_RS04965	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SIH_RS04980	COG2721	sulfolactate sulfo-lyase activity
SIH_RS04985	COG2721	sulfolactate sulfo-lyase activity
SIH_RS05010	COG1131	(ABC) transporter
SIH_RS05015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SIH_RS05030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SIH_RS05045	COG0601	transmembrane transport
SIH_RS05055	COG0444	Belongs to the ABC transporter superfamily
SIH_RS05060	COG4608	Belongs to the ABC transporter superfamily
SIH_RS05095	COG1131	(ABC) transporter
SIH_RS05165	COG1017	nitric oxide dioxygenase activity
SIH_RS05170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SIH_RS05170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SIH_RS05180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SIH_RS05225	COG0832	Belongs to the urease beta subunit family
SIH_RS05225	COG0831	urea catabolic process
SIH_RS05230	COG0804	urea catabolic process
SIH_RS05245	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SIH_RS05305	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SIH_RS05315	COG1024	Enoyl-CoA hydratase
SIH_RS05330	COG1741	Belongs to the pirin family
SIH_RS05430	COG2271	Major facilitator Superfamily
SIH_RS05475	COG1175	transmembrane transport
SIH_RS05480	COG3833	ABC-type maltose transport systems, permease component
SIH_RS05485	COG3842	ATPase activity
SIH_RS05495	COG2814	Major facilitator Superfamily
SIH_RS05530	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SIH_RS05560	COG1960	acyl-CoA dehydrogenase activity
SIH_RS05595	COG0477	Major facilitator Superfamily
SIH_RS05600	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SIH_RS05605	COG1131	(ABC) transporter
SIH_RS05630	COG0475	glutathione-regulated potassium exporter activity
SIH_RS05645	COG2048	Heterodisulfide reductase, subunit B
SIH_RS05675	COG0425	Belongs to the sulfur carrier protein TusA family
SIH_RS05680	COG2210	Belongs to the sulfur carrier protein TusA family
SIH_RS05690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIH_RS05725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SIH_RS05735	COG0095	Lipoate-protein ligase
SIH_RS05740	COG1832	CoA-binding protein
SIH_RS05770	COG0509	glycine decarboxylation via glycine cleavage system
SIH_RS05820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SIH_RS05865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SIH_RS05875	COG1846	Transcriptional regulator
SIH_RS05880	COG1136	(ABC) transporter
SIH_RS05880	COG0577	efflux transmembrane transporter activity
SIH_RS05890	COG1136	(ABC) transporter
SIH_RS05895	COG0114	fumarate hydratase activity
SIH_RS05905	COG0517	IMP dehydrogenase activity
SIH_RS05910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SIH_RS05910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SIH_RS05915	COG0531	amino acid
SIH_RS05920	COG0693	protein deglycase activity
SIH_RS05930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SIH_RS05935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SIH_RS05955	COG0509	glycine decarboxylation via glycine cleavage system
SIH_RS05995	COG0004	ammonium transporteR
SIH_RS06015	COG1185	polyribonucleotide nucleotidyltransferase activity
SIH_RS06060	COG1234	tRNA 3'-trailer cleavage
SIH_RS06075	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SIH_RS06110	COG0488	(ABC) transporter
SIH_RS06120	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SIH_RS06125	COG0725	ABC transporter, periplasmic molybdate-binding protein
SIH_RS06130	COG0300	oxidoreductase activity
SIH_RS06135	COG3383	formate dehydrogenase (NAD+) activity
SIH_RS06150	COG0650	Formate hydrogenlyase subunit 4
SIH_RS06160	COG0651	ATP synthesis coupled electron transport
SIH_RS06165	COG0649	NAD binding
SIH_RS06170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIH_RS06175	COG0651	ATP synthesis coupled electron transport
SIH_RS06185	COG2897	thiosulfate sulfurtransferase activity
SIH_RS06190	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SIH_RS06205	COG0028	Belongs to the TPP enzyme family
SIH_RS06210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIH_RS06220	COG0395	ABC-type sugar transport system, permease component
SIH_RS06235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SIH_RS06255	COG0157	Belongs to the NadC ModD family
SIH_RS06285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SIH_RS06295	COG0297	glycogen (starch) synthase activity
SIH_RS06305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SIH_RS06320	COG0469	pyruvate kinase activity
SIH_RS06335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SIH_RS06345	COG0528	UMP kinase activity
SIH_RS06355	COG1028	Short-chain dehydrogenase reductase Sdr
SIH_RS06370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SIH_RS06375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SIH_RS06385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SIH_RS06415	COG1110	DNA topoisomerase II activity
SIH_RS06455	COG0154	amidase activity
SIH_RS06470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SIH_RS06470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SIH_RS06525	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
SIH_RS06555	COG0252	asparaginase activity
SIH_RS06560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SIH_RS06590	COG1372	Participates in initiation and elongation during chromosome replication
SIH_RS06590	COG0719	Fe-S assembly protein
SIH_RS06595	COG0719	Fe-S assembly protein
SIH_RS06600	COG0396	ATPase activity
SIH_RS06620	COG0509	glycine decarboxylation via glycine cleavage system
SIH_RS06625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SIH_RS06635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SIH_RS06655	COG0148	phosphopyruvate hydratase activity
SIH_RS06675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIH_RS06680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SIH_RS06695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SIH_RS06725	COG0644	oxidoreductase
SIH_RS06730	COG0525	valine-tRNA ligase activity
SIH_RS06735	COG0436	Aminotransferase
SIH_RS06740	COG0134	indole-3-glycerol-phosphate synthase activity
SIH_RS06745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SIH_RS06745	COG0512	Glutamine amidotransferase of anthranilate synthase
SIH_RS06750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SIH_RS06755	COG0135	phosphoribosylanthranilate isomerase activity
SIH_RS06765	COG0159	tryptophan synthase activity
SIH_RS06770	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SIH_RS06775	COG1254	Belongs to the acylphosphatase family
SIH_RS06780	COG1260	myo-inositol-1-phosphate synthase
SIH_RS06785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SIH_RS06785	COG0574	Belongs to the PEP-utilizing enzyme family
SIH_RS06805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SIH_RS06810	COG0460	homoserine dehydrogenase
SIH_RS06810	COG0527	aspartate kinase activity
SIH_RS06830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SIH_RS06865	COG0459	protein refolding
SIH_RS06910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SIH_RS06970	COG0315	cyclic pyranopterin monophosphate synthase activity
SIH_RS06975	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SIH_RS06980	COG2255	four-way junction helicase activity
SIH_RS06985	COG1881	PFAM PEBP family protein
SIH_RS06990	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SIH_RS07000	COG1063	alcohol dehydrogenase
SIH_RS07025	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SIH_RS07035	COG1047	Peptidyl-prolyl cis-trans
SIH_RS07050	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SIH_RS07065	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SIH_RS07105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SIH_RS07110	COG2264	protein methyltransferase activity
SIH_RS07115	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SIH_RS07125	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SIH_RS07170	COG1185	polyribonucleotide nucleotidyltransferase activity
SIH_RS07195	COG0322	excinuclease ABC activity
SIH_RS07200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SIH_RS07220	COG0473	3-isopropylmalate dehydrogenase activity
SIH_RS07225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SIH_RS07235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SIH_RS07250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SIH_RS07255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SIH_RS07260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SIH_RS07265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SIH_RS07270	COG0255	Belongs to the universal ribosomal protein uL29 family
SIH_RS07280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SIH_RS07285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SIH_RS07290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SIH_RS07300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SIH_RS07310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SIH_RS07315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SIH_RS07335	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SIH_RS07370	COG0563	adenylate kinase activity
SIH_RS07440	COG0009	L-threonylcarbamoyladenylate synthase
SIH_RS07445	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIH_RS07450	COG2379	hydroxypyruvate reductase
SIH_RS07460	COG1321	iron dependent repressor
SIH_RS07480	COG2226	methyltransferase
SIH_RS07495	COG0303	'Molybdopterin
SIH_RS07510	COG0402	S-adenosylhomocysteine deaminase activity
SIH_RS07525	COG0067	glutamate synthase
SIH_RS07530	COG0069	glutamate synthase activity
SIH_RS07540	COG0577	efflux transmembrane transporter activity
SIH_RS07540	COG1136	(ABC) transporter
SIH_RS07580	COG1201	RNA secondary structure unwinding
SIH_RS07640	COG0312	modulator of DNA gyrase
SIH_RS07645	COG0312	modulator of DNA gyrase
SIH_RS07650	COG0864	Transcriptional regulator
SIH_RS07660	COG0460	homoserine dehydrogenase
SIH_RS07675	COG1024	Enoyl-CoA hydratase
SIH_RS07715	COG1250	3-hydroxyacyl-CoA dehydrogenase
SIH_RS07725	COG0189	ligase activity
SIH_RS07735	COG0505	Belongs to the CarA family
SIH_RS07740	COG0165	Argininosuccinate lyase
SIH_RS07745	COG0137	argininosuccinate synthase activity
SIH_RS07760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SIH_RS07765	COG0151	Belongs to the GarS family
SIH_RS07770	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SIH_RS07775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SIH_RS07785	COG0047	phosphoribosylformylglycinamidine synthase activity
SIH_RS07795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SIH_RS07800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIH_RS07800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIH_RS07805	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SIH_RS07810	COG0602	queuosine metabolic process
SIH_RS07845	COG0284	orotidine-5'-phosphate decarboxylase activity
SIH_RS07850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SIH_RS07855	COG0540	Belongs to the ATCase OTCase family
SIH_RS07860	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
SIH_RS07875	COG0167	dihydroorotate dehydrogenase activity
SIH_RS07890	COG2095	MarC family integral membrane protein
SIH_RS07895	COG1522	sequence-specific DNA binding
SIH_RS07910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SIH_RS07915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SIH_RS07920	COG2151	metal-sulfur cluster biosynthetic enzyme
SIH_RS07930	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SIH_RS07935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SIH_RS07935	COG0140	phosphoribosyl-ATP diphosphatase activity
SIH_RS07940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SIH_RS07945	COG0107	imidazoleglycerol-phosphate synthase activity
SIH_RS07950	COG0131	Imidazoleglycerol-phosphate dehydratase
SIH_RS07955	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SIH_RS07960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SIH_RS07965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SIH_RS07975	COG0495	leucyl-tRNA aminoacylation
SIH_RS07980	COG2096	Adenosyltransferase
SIH_RS07985	COG0037	tRNA processing
SIH_RS07995	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SIH_RS08020	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SIH_RS08030	COG0028	Belongs to the TPP enzyme family
SIH_RS08040	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SIH_RS08055	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SIH_RS08060	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SIH_RS08070	COG0442	prolyl-tRNA aminoacylation
SIH_RS08085	COG1394	ATPase activity, coupled to movement of substances
SIH_RS08095	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SIH_RS08115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIH_RS08145	COG0417	DNA replication proofreading
SIH_RS08165	COG0668	transmembrane transport
SIH_RS08175	COG0126	phosphoglycerate kinase activity
SIH_RS08185	COG0589	response to stress
SIH_RS08190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SIH_RS08210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SIH_RS08215	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SIH_RS08345	COG0495	leucyl-tRNA aminoacylation
SIH_RS08395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SIH_RS08405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SIH_RS08415	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SIH_RS08430	COG0805	protein transport
SIH_RS08440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SIH_RS08465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SIH_RS08475	COG0556	nucleotide-excision repair
SIH_RS08480	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SIH_RS08490	COG3276	selenocysteine insertion sequence binding
SIH_RS08510	COG1992	Thiamine-phosphate synthase
SIH_RS08510	COG0351	phosphomethylpyrimidine kinase
SIH_RS08540	COG0489	protein tyrosine kinase activity
SIH_RS08560	COG1280	lysine exporter protein (LysE YggA)
SIH_RS08590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SIH_RS08600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SIH_RS08640	COG0423	glycine-tRNA ligase activity
SIH_RS08670	COG0163	prenyltransferase activity
SIH_RS08675	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SIH_RS08695	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SIH_RS08700	COG0667	Aldo Keto reductase
SIH_RS08745	COG1110	DNA topoisomerase II activity
SIH_RS08750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIH_RS08755	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SIH_RS08770	COG0539	negative regulation of cytoplasmic translation
SIH_RS08800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SIH_RS08815	COG1797	cobyrinic acid a,c-diamide synthase activity
SIH_RS08835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SIH_RS08845	COG0402	S-adenosylhomocysteine deaminase activity
SIH_RS08865	COG1201	RNA secondary structure unwinding
SIH_RS08880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SIH_RS08885	COG2813	Specifically methylates the guanine in position
SIH_RS08895	COG1444	tRNA N-acetyltransferase activity
SIH_RS08940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SIH_RS08945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SIH_RS08955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SIH_RS08980	COG0475	glutathione-regulated potassium exporter activity
SIH_RS08990	COG0535	radical SAM domain protein
SIH_RS08995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SIH_RS09000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SIH_RS09000	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SIH_RS09010	COG0318	PFAM AMP-dependent synthetase and ligase
SIH_RS09015	COG3118	belongs to the thioredoxin family
SIH_RS09020	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SIH_RS09035	COG0302	gtp cyclohydrolase
SIH_RS09045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SIH_RS09060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SIH_RS09125	COG0552	protein localization to endoplasmic reticulum
SIH_RS09140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SIH_RS09160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SIH_RS09190	COG0301	tRNA thio-modification
SIH_RS09195	COG1260	myo-inositol-1-phosphate synthase
SIH_RS09200	COG1007	ATP synthesis coupled electron transport
SIH_RS09205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SIH_RS09210	COG0713	ATP synthesis coupled electron transport
SIH_RS09220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIH_RS09225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SIH_RS09230	COG0649	NAD binding
SIH_RS09235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIH_RS09245	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SIH_RS09265	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SIH_RS09270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SIH_RS09310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SIH_RS09320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SIH_RS09325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SIH_RS09330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SIH_RS09335	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SIH_RS09340	COG0077	Prephenate dehydratase
SIH_RS09340	COG1605	Chorismate mutase
SIH_RS09345	COG3958	Transketolase
SIH_RS09350	COG3959	Transketolase, thiamine diphosphate binding domain
SIH_RS09355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SIH_RS09375	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SIH_RS09385	COG1185	polyribonucleotide nucleotidyltransferase activity
SIH_RS09410	COG0477	Major facilitator Superfamily
SIH_RS09420	COG1121	(ABC) transporter
SIH_RS09425	COG1980	fructose-bisphosphate aldolase activity
SIH_RS09450	COG0459	protein refolding
SIH_RS09465	COG0124	histidyl-tRNA synthetase
SIH_RS09500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIH_RS09510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SIH_RS09550	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SIH_RS09585	COG1056	cytidyltransferase-related domain
SIH_RS09585	COG1051	belongs to the nudix hydrolase family
SIH_RS09600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SIH_RS09600	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SIH_RS09625	COG0077	Prephenate dehydratase
SIH_RS09625	COG1605	Chorismate mutase
SIH_RS09640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SIH_RS09655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SIH_RS09670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SIH_RS09685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SIH_RS09690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SIH_RS09705	COG0105	UTP biosynthetic process
SIH_RS09720	COG0085	RNA polymerase activity
SIH_RS09725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SIH_RS09730	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SIH_RS09755	COG0049	tRNA binding
SIH_RS09760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SIH_RS09765	COG0051	transcription antitermination factor activity, RNA binding
SIH_RS09805	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SIH_RS09810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SIH_RS09850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SIH_RS09870	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SIH_RS09875	COG0504	CTP synthase activity
SIH_RS09890	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SIH_RS09920	COG2078	PFAM AMMECR1 domain protein
SIH_RS09935	COG0717	Belongs to the dCTP deaminase family
SIH_RS09940	COG1793	dna ligase
SIH_RS09945	COG1793	dna ligase
SIH_RS09945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SIH_RS09950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SIH_RS09975	COG0181	hydroxymethylbilane synthase activity
SIH_RS09980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SIH_RS09985	COG0113	porphobilinogen synthase activity
SIH_RS09990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SIH_RS10010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIH_RS10030	COG0585	pseudouridine synthase activity
SIH_RS10035	COG0017	Asparaginyl-tRNA synthetase
SIH_RS10050	COG0028	Belongs to the TPP enzyme family
SIH_RS10065	COG1122	ATPase activity
SIH_RS10095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SIH_RS10100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIH_RS10105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SIH_RS10110	COG0189	ligase activity
SIH_RS10125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SIH_RS10130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SIH_RS10145	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SIH_RS10190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SIH_RS10230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SIH_RS10235	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SIH_RS10285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SIH_RS10300	COG1201	RNA secondary structure unwinding
SIH_RS10305	COG0617	tRNA 3'-terminal CCA addition
SIH_RS10305	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SIH_RS10305	COG0517	IMP dehydrogenase activity
SIH_RS10330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SIH_RS10335	COG1058	Belongs to the CinA family
SIH_RS10335	COG1546	Belongs to the CinA family
SIH_RS10340	COG2267	carboxylic ester hydrolase activity
SIH_RS10355	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SIH_RS10380	COG1078	dGTPase activity
SIH_RS10385	COG0561	phosphatase activity
SIH_RS10390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SIH_RS10400	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SIH_RS10430	COG0456	acetyltransferase
SIH_RS10430	COG1214	PFAM Peptidase M22, glycoprotease
SIH_RS10445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SIH_RS10460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SIH_RS10470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SIH_RS10480	COG0200	Binds to the 23S rRNA
SIH_RS10485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SIH_RS10490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SIH_RS10500	COG0052	Belongs to the universal ribosomal protein uS2 family
SIH_RS10505	COG1355	regulation of microtubule-based process
SIH_RS10520	COG1304	FMN binding
SIH_RS10575	COG1131	(ABC) transporter
SIH_RS10605	COG0084	hydrolase, TatD family'
SIH_RS10620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SIH_RS10660	COG1192	Involved in chromosome partitioning
SIH_RS10680	COG3620	sequence-specific DNA binding
SIH_RS10680	COG0617	tRNA 3'-terminal CCA addition
SIH_RS10680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SIH_RS10690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SIH_RS10735	COG1201	RNA secondary structure unwinding
SIH_RS10745	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SIH_RS10770	COG2860	membrane
SIH_RS10785	COG0123	including yeast histone deacetylase and acetoin utilization protein
SIH_RS10805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SIH_RS10810	COG0352	thiamine-phosphate diphosphorylase activity
SIH_RS10810	COG0351	phosphomethylpyrimidine kinase
SIH_RS10820	COG1215	transferase activity, transferring glycosyl groups
SIH_RS10870	COG0463	Glycosyl transferase, family 2
SIH_RS10890	COG1063	alcohol dehydrogenase
SIH_RS10910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SIH_RS10910	COG0519	Catalyzes the synthesis of GMP from XMP
SIH_RS10915	COG0501	Belongs to the peptidase M48B family
SIH_RS10920	COG0516	GMP reductase activity
SIH_RS10920	COG0517	IMP dehydrogenase activity
SIH_RS10930	COG1830	Aldolase
SIH_RS10955	COG0405	Gamma-glutamyltransferase
SIH_RS10970	COG1444	tRNA N-acetyltransferase activity
SIH_RS10985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SIH_RS10995	COG0656	L-ascorbic acid biosynthetic process
SIH_RS11010	COG0251	oxidation-reduction process
SIH_RS11015	COG0517	IMP dehydrogenase activity
SIH_RS11015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SIH_RS11015	COG0617	tRNA 3'-terminal CCA addition
SIH_RS11020	COG1063	alcohol dehydrogenase
SIH_RS11025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIH_RS11035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SIH_RS11045	COG4948	Mandelate Racemase Muconate Lactonizing
SIH_RS11050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIH_RS11055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SIH_RS11060	COG1012	belongs to the aldehyde dehydrogenase family
SIH_RS11070	COG0243	molybdopterin cofactor binding
SIH_RS11125	COG0833	amino acid
SIH_RS11130	COG0589	response to stress
SIH_RS11145	COG2814	Major facilitator Superfamily
SIH_RS11215	COG1733	regulation of RNA biosynthetic process
SIH_RS11225	COG0516	GMP reductase activity
SIH_RS11225	COG0517	IMP dehydrogenase activity
SIH_RS11230	COG1720	tRNA m6t6A37 methyltransferase activity
SIH_RS11265	COG0277	FAD linked oxidase domain protein
SIH_RS11270	COG0247	lactate metabolic process
SIH_RS11275	COG0095	Lipoate-protein ligase
SIH_RS11280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SIH_RS11295	COG0655	NAD(P)H dehydrogenase (quinone) activity
SIH_RS11320	COG0477	Major facilitator Superfamily
SIH_RS11330	COG1960	acyl-CoA dehydrogenase activity
SIH_RS11340	COG2271	Major facilitator Superfamily
SIH_RS11370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SIH_RS11390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIH_RS11400	COG1139	Iron-sulfur cluster binding protein
SIH_RS11405	COG2814	Major facilitator Superfamily
SIH_RS11425	COG4948	Mandelate Racemase Muconate Lactonizing
SIH_RS11435	COG0477	Major facilitator Superfamily
SIH_RS11440	COG2271	Major facilitator Superfamily
SIH_RS11445	COG0179	Fumarylacetoacetate (FAA) hydrolase
SIH_RS11455	COG2267	carboxylic ester hydrolase activity
SIH_RS11465	COG1028	Short-chain dehydrogenase reductase Sdr
SIH_RS11510	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SIH_RS11550	COG1122	ATPase activity
SIH_RS11590	COG0425	Belongs to the sulfur carrier protein TusA family
SIH_RS11610	COG1121	(ABC) transporter
SIH_RS11670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIH_RS11680	COG3842	ATPase activity
SIH_RS11685	COG0395	ABC-type sugar transport system, permease component
SIH_RS11700	COG0318	PFAM AMP-dependent synthetase and ligase
SIH_RS11735	COG0667	Aldo Keto reductase
SIH_RS11760	COG0673	inositol 2-dehydrogenase activity
SIH_RS11770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SIH_RS11775	COG0444	Belongs to the ABC transporter superfamily
SIH_RS11780	COG4608	Belongs to the ABC transporter superfamily
SIH_RS11795	COG3386	PFAM SMP-30 Gluconolaconase
SIH_RS11805	COG3250	beta-galactosidase activity
SIH_RS11810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIH_RS11815	COG1472	Belongs to the glycosyl hydrolase 3 family
SIH_RS11860	COG3408	Glycogen debranching enzyme
SIH_RS11885	COG1501	Belongs to the glycosyl hydrolase 31 family
SIH_RS11895	COG2723	6-phospho-beta-galactosidase activity
SIH_RS11915	COG0667	Aldo Keto reductase
SIH_RS11925	COG1132	(ABC) transporter
SIH_RS11950	COG0673	inositol 2-dehydrogenase activity
SIH_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
SIH_RS11980	COG0459	protein refolding
SIH_RS11985	COG4948	Mandelate Racemase Muconate Lactonizing
SIH_RS11990	COG1250	3-hydroxyacyl-CoA dehydrogenase
SIH_RS11995	COG1914	H( )-stimulated, divalent metal cation uptake system
SIH_RS12070	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SIH_RS12090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SIH_RS12105	COG2857	Cytochrome c1
SIH_RS12105	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SIH_RS12165	COG0601	transmembrane transport
SIH_RS12170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SIH_RS12175	COG0444	Belongs to the ABC transporter superfamily
SIH_RS12180	COG4608	Belongs to the ABC transporter superfamily
SIH_RS12280	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SIH_RS12315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SIH_RS12320	COG1648	precorrin-2 dehydrogenase activity
SIH_RS12320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SIH_RS12325	COG2897	thiosulfate sulfurtransferase activity
SIH_RS12355	COG0667	Aldo Keto reductase
SIH_RS12375	COG3608	succinylglutamate desuccinylase aspartoacylase
SIH_RS12375	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SIH_RS12385	COG1960	acyl-CoA dehydrogenase activity
SIH_RS12390	COG0318	PFAM AMP-dependent synthetase and ligase
SIH_RS12405	COG1250	3-hydroxyacyl-CoA dehydrogenase
SIH_RS12415	COG0281	malic enzyme
SIH_RS12440	COG1584	GPR1 FUN34 yaaH family protein
SIH_RS12445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIH_RS12480	COG0477	Major facilitator Superfamily
SIH_RS12485	COG3842	ATPase activity
SIH_RS12490	COG0395	ABC-type sugar transport system, permease component
SIH_RS12545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIH_RS12585	COG3383	formate dehydrogenase (NAD+) activity
SIH_RS12595	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SIH_RS12600	COG3848	Pyruvate phosphate dikinase
SIH_RS12600	COG0574	Belongs to the PEP-utilizing enzyme family
SIH_RS12610	COG0644	oxidoreductase
SIH_RS12615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SIH_RS12620	COG1013	pyruvate-flavodoxin oxidoreductase activity
SIH_RS12625	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIH_RS12625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SIH_RS12655	COG0318	PFAM AMP-dependent synthetase and ligase
SIH_RS12705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SIH_RS12745	COG1063	alcohol dehydrogenase
SIH_RS12770	COG0243	molybdopterin cofactor binding
SIH_RS12860	COG0668	transmembrane transport
SIH_RS12865	COG0586	Pfam SNARE associated Golgi protein
SIH_RS12875	COG0022	dehydrogenase e1 component
SIH_RS12880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SIH_RS12885	COG0656	L-ascorbic acid biosynthetic process
SIH_RS12890	COG0589	response to stress
SIH_RS12900	COG0644	oxidoreductase
SIH_RS12915	COG0028	Belongs to the TPP enzyme family
SIH_RS12930	COG0402	S-adenosylhomocysteine deaminase activity
SIH_RS12950	COG0492	ferredoxin-NADP+ reductase activity
SIH_RS12960	COG2086	electron transfer activity
SIH_RS12970	COG1960	acyl-CoA dehydrogenase activity
SIH_RS12985	COG0437	4 iron, 4 sulfur cluster binding
SIH_RS12990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SIH_RS12995	COG1144	Oxidoreductase
SIH_RS13000	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIH_RS13005	COG1013	pyruvate-flavodoxin oxidoreductase activity
SIH_RS13010	COG0438	transferase activity, transferring glycosyl groups
SIH_RS13015	COG3387	PFAM Glycoside hydrolase 15-related
SIH_RS13070	COG3387	PFAM Glycoside hydrolase 15-related
SIH_RS13080	COG0517	IMP dehydrogenase activity
SIH_RS13090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIH_RS13155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIH_RS13165	COG2223	nitrite transmembrane transporter activity
SIH_RS13180	COG0395	ABC-type sugar transport system, permease component
SIH_RS13185	COG3842	ATPase activity
SIH_RS13215	COG0813	purine-nucleoside phosphorylase activity
SIH_RS13220	COG3386	PFAM SMP-30 Gluconolaconase
SIH_RS13225	COG2814	Major facilitator Superfamily
SIH_RS13250	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SIH_RS13270	COG4274	PFAM GYD family protein
SIH_RS13280	COG4946	Tricorn protease homolog
SIH_RS13280	COG0823	Involved in the tonB-independent uptake of proteins
SIH_RS13280	COG1506	peptidase
SIH_RS13295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIH_RS13400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SIH_RS13450	COG4608	Belongs to the ABC transporter superfamily
SIH_RS13455	COG0444	Belongs to the ABC transporter superfamily
SIH_RS13470	COG0601	transmembrane transport
SIH_RS13485	COG4948	Mandelate Racemase Muconate Lactonizing
SIH_RS13490	COG1028	Short-chain dehydrogenase reductase Sdr
SIH_RS13545	COG2217	Heavy metal translocating P-type atpase
SIH_RS13555	COG4555	ABC transporter
SIH_RS13580	COG1592	Rubrerythrin
SIH_RS13615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SIH_RS13665	COG0183	Belongs to the thiolase family
SIH_RS13675	COG1024	Enoyl-CoA hydratase
SIH_RS13690	COG0531	amino acid
SIH_RS13725	COG0601	transmembrane transport
SIH_RS13730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SIH_RS13735	COG0444	Belongs to the ABC transporter superfamily
SIH_RS13740	COG4608	Belongs to the ABC transporter superfamily
SIH_RS13750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SIH_RS13755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SIH_RS13770	COG0438	transferase activity, transferring glycosyl groups
SIH_RS13790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SIH_RS13815	COG1131	(ABC) transporter
SIH_RS13820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SIH_RS13825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SIH_RS13830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SIH_RS13850	COG0675	Transposase, IS605 OrfB family
SIH_RS13860	COG0149	triose-phosphate isomerase activity
SIH_RS13875	COG0372	Belongs to the citrate synthase family
SIH_RS13880	COG0516	GMP reductase activity
SIH_RS13880	COG0517	IMP dehydrogenase activity
SIH_RS13885	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SIH_RS13890	COG2079	MmgE PrpD family protein
SIH_RS13895	COG0039	L-malate dehydrogenase activity
SIH_RS13900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SIH_RS13930	COG0750	zinc metalloprotease
SIH_RS13950	COG1489	DNA binding
SIH_RS13980	COG0778	Nitroreductase
SIH_RS13985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIH_RS14130	COG0561	phosphatase activity
SIH_RS14140	COG1011	Hydrolase
SIH_RS14155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SIH_RS14195	COG3253	May function as heme-dependent peroxidase
SIH_RS14210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SIH_RS14240	COG2226	methyltransferase
SIH_RS14265	COG0538	isocitrate dehydrogenase activity
SIH_RS14670	COG1017	nitric oxide dioxygenase activity
SIH_RS14715	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate