locus-tag	class	description
SIL_RS00025	COG2154	pterin-4-alpha-carbinolamine dehydratase
SIL_RS00105	COG1331	Highly conserved protein containing a thioredoxin domain
SIL_RS00115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SIL_RS00125	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SIL_RS00150	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SIL_RS00165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIL_RS00175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SIL_RS00180	COG2814	Major facilitator Superfamily
SIL_RS00190	COG0492	ferredoxin-NADP+ reductase activity
SIL_RS00260	COG0588	phosphoglycerate mutase activity
SIL_RS00280	COG1957	nucleoside hydrolase
SIL_RS00330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SIL_RS00330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SIL_RS00335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SIL_RS00340	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
SIL_RS00360	COG0596	Alpha beta hydrolase
SIL_RS00370	COG1703	isobutyryl-CoA mutase activity
SIL_RS00375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SIL_RS00415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIL_RS00420	COG1573	uracil-dna glycosylase
SIL_RS00425	COG1028	Short-chain dehydrogenase reductase Sdr
SIL_RS00450	COG0215	cysteine-tRNA ligase activity
SIL_RS00455	COG2222	sugar isomerase
SIL_RS00465	COG0446	pyridine nucleotide-disulphide oxidoreductase
SIL_RS00475	COG0433	COG0433 Predicted ATPase
SIL_RS00485	COG1607	acyl-coa hydrolase
SIL_RS00495	COG1028	Short-chain dehydrogenase reductase Sdr
SIL_RS00500	COG0708	Exodeoxyribonuclease III
SIL_RS00505	COG2815	serine threonine protein kinase
SIL_RS00505	COG0515	serine threonine protein kinase
SIL_RS00540	COG1648	precorrin-2 dehydrogenase activity
SIL_RS00540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SIL_RS00550	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SIL_RS00575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIL_RS00645	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SIL_RS00650	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SIL_RS00665	COG0189	ligase activity
SIL_RS00705	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SIL_RS00725	COG1053	succinate dehydrogenase
SIL_RS00745	COG2304	oxidoreductase activity
SIL_RS00750	COG0714	Associated with various cellular activities
SIL_RS00775	COG0083	homoserine kinase activity
SIL_RS00780	COG0626	cystathionine gamma-synthase activity
SIL_RS00820	COG0183	Belongs to the thiolase family
SIL_RS00825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SIL_RS00865	COG1215	transferase activity, transferring glycosyl groups
SIL_RS00870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SIL_RS00880	COG0351	phosphomethylpyrimidine kinase
SIL_RS00885	COG0314	molybdopterin synthase activity
SIL_RS00910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SIL_RS00920	COG1131	(ABC) transporter
SIL_RS00950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SIL_RS00955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SIL_RS00985	COG0720	synthase
SIL_RS01000	COG0492	ferredoxin-NADP+ reductase activity
SIL_RS01010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIL_RS01030	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SIL_RS01030	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SIL_RS01040	COG0071	Belongs to the small heat shock protein (HSP20) family
SIL_RS01100	COG0402	S-adenosylhomocysteine deaminase activity
SIL_RS01125	COG0430	RNA-3'-phosphate cyclase activity
SIL_RS01135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SIL_RS01140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SIL_RS01145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIL_RS01155	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SIL_RS01165	COG1515	deoxyribonuclease V activity
SIL_RS01170	COG1335	isochorismatase
SIL_RS01205	COG4581	dead DEAH box helicase
SIL_RS01215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SIL_RS01225	COG0439	Biotin carboxylase
SIL_RS01235	COG1116	anion transmembrane transporter activity
SIL_RS01245	COG0066	3-isopropylmalate dehydratase activity
SIL_RS01250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SIL_RS01255	COG0415	Belongs to the DNA photolyase family
SIL_RS01290	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SIL_RS01330	COG0045	succinate-CoA ligase (ADP-forming) activity
SIL_RS01345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SIL_RS01350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SIL_RS01380	COG0657	acetylesterase activity
SIL_RS01385	COG1063	alcohol dehydrogenase
SIL_RS01390	COG0183	Belongs to the thiolase family
SIL_RS01395	COG1960	acyl-CoA dehydrogenase activity
SIL_RS01400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SIL_RS01405	COG1028	Short-chain dehydrogenase reductase Sdr
SIL_RS01410	COG1063	alcohol dehydrogenase
SIL_RS01450	COG0318	PFAM AMP-dependent synthetase and ligase
SIL_RS01455	COG1960	acyl-CoA dehydrogenase activity
SIL_RS01460	COG1024	Enoyl-CoA hydratase
SIL_RS01465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIL_RS01470	COG0477	Major facilitator Superfamily
SIL_RS01470	COG2814	Major facilitator Superfamily
SIL_RS01505	COG0318	PFAM AMP-dependent synthetase and ligase
SIL_RS01515	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SIL_RS01520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SIL_RS01600	COG0432	Pfam Uncharacterised protein family UPF0047
SIL_RS01605	COG1305	Transglutaminase-like
SIL_RS01615	COG1522	sequence-specific DNA binding
SIL_RS01620	COG1013	pyruvate-flavodoxin oxidoreductase activity
SIL_RS01625	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIL_RS01640	COG1620	l-lactate permease
SIL_RS01665	COG0450	alkyl hydroperoxide reductase
SIL_RS01710	COG3573	Dehydrogenase
SIL_RS01730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SIL_RS01735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SIL_RS01745	COG2062	phosphohistidine phosphatase, SixA
SIL_RS01755	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIL_RS01840	COG1473	amidohydrolase
SIL_RS01920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SIL_RS01990	COG0675	Transposase, IS605 OrfB family
SIL_RS02000	COG1846	Transcriptional regulator
SIL_RS02005	COG0477	Major facilitator Superfamily
SIL_RS02025	COG0277	FAD linked oxidase domain protein
SIL_RS02055	COG0028	Belongs to the TPP enzyme family
SIL_RS02080	COG1741	Belongs to the pirin family
SIL_RS02100	COG1024	Enoyl-CoA hydratase
SIL_RS02110	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SIL_RS02160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SIL_RS02170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SIL_RS02170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SIL_RS02175	COG1017	nitric oxide dioxygenase activity
SIL_RS02195	COG0601	transmembrane transport
SIL_RS02205	COG0444	Belongs to the ABC transporter superfamily
SIL_RS02210	COG4608	Belongs to the ABC transporter superfamily
SIL_RS02225	COG4608	Belongs to the ABC transporter superfamily
SIL_RS02230	COG0444	Belongs to the ABC transporter superfamily
SIL_RS02240	COG0601	transmembrane transport
SIL_RS02255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SIL_RS02270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SIL_RS02275	COG1131	(ABC) transporter
SIL_RS02300	COG2721	sulfolactate sulfo-lyase activity
SIL_RS02305	COG2721	sulfolactate sulfo-lyase activity
SIL_RS02325	COG1802	Transcriptional regulator
SIL_RS02330	COG2301	Belongs to the HpcH HpaI aldolase family
SIL_RS02335	COG2050	protein possibly involved in aromatic compounds catabolism
SIL_RS02335	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SIL_RS02355	COG2181	nitrate reductase activity
SIL_RS02360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SIL_RS02365	COG1140	nitrate reductase beta subunit
SIL_RS02395	COG0058	SHG alpha-glucan phosphorylase activity
SIL_RS02445	COG1373	ATPase (AAA superfamily
SIL_RS02450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SIL_RS02475	COG2084	Dehydrogenase
SIL_RS02525	COG0412	Dienelactone hydrolase
SIL_RS02565	COG4946	Tricorn protease homolog
SIL_RS02565	COG0793	Belongs to the peptidase S41A family
SIL_RS02570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SIL_RS02615	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SIL_RS02655	COG1960	acyl-CoA dehydrogenase activity
SIL_RS02660	COG0318	PFAM AMP-dependent synthetase and ligase
SIL_RS02675	COG2814	Major facilitator Superfamily
SIL_RS02730	COG0243	molybdopterin cofactor binding
SIL_RS02805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIL_RS02850	COG1953	Uracil, thiamine, allantoin
SIL_RS02880	COG2814	Major facilitator Superfamily
SIL_RS02885	COG4948	Mandelate Racemase Muconate Lactonizing
SIL_RS02940	COG0179	Fumarylacetoacetate (FAA) hydrolase
SIL_RS02975	COG3547	Transposase (IS116 IS110 IS902 family)
SIL_RS03050	COG1518	maintenance of DNA repeat elements
SIL_RS03105	COG1131	(ABC) transporter
SIL_RS03195	COG1028	Short-chain dehydrogenase reductase Sdr
SIL_RS03205	COG0477	Major facilitator Superfamily
SIL_RS03380	COG0589	response to stress
SIL_RS03395	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SIL_RS03400	COG1968	undecaprenyl-diphosphatase activity
SIL_RS03410	COG1968	undecaprenyl-diphosphatase activity
SIL_RS03415	COG0501	Belongs to the peptidase M48B family
SIL_RS03465	COG2226	methyltransferase
SIL_RS03485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SIL_RS03485	COG0045	succinate-CoA ligase (ADP-forming) activity
SIL_RS03485	COG1042	CoA-binding domain protein
SIL_RS03510	COG0425	Belongs to the sulfur carrier protein TusA family
SIL_RS03520	COG1024	Enoyl-CoA hydratase
SIL_RS03570	COG1011	Hydrolase
SIL_RS03615	COG0477	Major facilitator Superfamily
SIL_RS03625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIL_RS03630	COG1953	Uracil, thiamine, allantoin
SIL_RS03635	COG0531	amino acid
SIL_RS03640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SIL_RS03665	COG0477	Major facilitator Superfamily
SIL_RS03720	COG2368	4-hydroxyphenylacetate
SIL_RS03730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SIL_RS03735	COG2271	Major facilitator Superfamily
SIL_RS03745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIL_RS03750	COG1960	acyl-CoA dehydrogenase activity
SIL_RS03795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIL_RS03800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SIL_RS03810	COG0598	Magnesium transport protein CorA
SIL_RS03845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SIL_RS03865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SIL_RS03900	COG1012	belongs to the aldehyde dehydrogenase family
SIL_RS03905	COG0535	radical SAM domain protein
SIL_RS03910	COG0535	radical SAM domain protein
SIL_RS04030	COG0463	Glycosyl transferase, family 2
SIL_RS04055	COG1216	Glycosyl transferase, family 2
SIL_RS04055	COG0463	Glycosyl transferase, family 2
SIL_RS04060	COG0438	transferase activity, transferring glycosyl groups
SIL_RS04070	COG0463	Glycosyl transferase, family 2
SIL_RS04085	COG1216	Glycosyl transferase, family 2
SIL_RS04095	COG0438	transferase activity, transferring glycosyl groups
SIL_RS04100	COG1215	transferase activity, transferring glycosyl groups
SIL_RS04125	COG0438	transferase activity, transferring glycosyl groups
SIL_RS04175	COG0714	Associated with various cellular activities
SIL_RS04185	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SIL_RS04235	COG1215	transferase activity, transferring glycosyl groups
SIL_RS04300	COG1215	transferase activity, transferring glycosyl groups
SIL_RS04315	COG1216	Glycosyl transferase, family 2
SIL_RS04315	COG1442	glycosyl transferase family 8
SIL_RS04355	COG1216	Glycosyl transferase, family 2
SIL_RS04470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIL_RS04490	COG1131	(ABC) transporter
SIL_RS04510	COG1122	ATPase activity
SIL_RS04525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SIL_RS04530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIL_RS04540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SIL_RS04545	COG2224	Isocitrate lyase
SIL_RS04655	COG2271	Major facilitator Superfamily
SIL_RS04700	COG1175	transmembrane transport
SIL_RS04705	COG3833	ABC-type maltose transport systems, permease component
SIL_RS04710	COG3842	ATPase activity
SIL_RS04720	COG2814	Major facilitator Superfamily
SIL_RS04750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SIL_RS04770	COG1960	acyl-CoA dehydrogenase activity
SIL_RS04805	COG0477	Major facilitator Superfamily
SIL_RS04810	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SIL_RS04815	COG1131	(ABC) transporter
SIL_RS04840	COG0475	glutathione-regulated potassium exporter activity
SIL_RS04845	COG0675	Transposase, IS605 OrfB family
SIL_RS04865	COG2048	Heterodisulfide reductase, subunit B
SIL_RS04895	COG0425	Belongs to the sulfur carrier protein TusA family
SIL_RS04900	COG2210	Belongs to the sulfur carrier protein TusA family
SIL_RS04910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIL_RS04955	COG0095	Lipoate-protein ligase
SIL_RS04960	COG1832	CoA-binding protein
SIL_RS04990	COG0509	glycine decarboxylation via glycine cleavage system
SIL_RS05000	COG2271	Major facilitator Superfamily
SIL_RS05040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SIL_RS05085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SIL_RS05095	COG1846	Transcriptional regulator
SIL_RS05100	COG1136	(ABC) transporter
SIL_RS05100	COG0577	efflux transmembrane transporter activity
SIL_RS05110	COG1136	(ABC) transporter
SIL_RS05115	COG0114	fumarate hydratase activity
SIL_RS05125	COG0517	IMP dehydrogenase activity
SIL_RS05130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SIL_RS05130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SIL_RS05135	COG0531	amino acid
SIL_RS05140	COG0693	protein deglycase activity
SIL_RS05150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SIL_RS05155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SIL_RS05175	COG0509	glycine decarboxylation via glycine cleavage system
SIL_RS05215	COG0004	ammonium transporteR
SIL_RS05235	COG1185	polyribonucleotide nucleotidyltransferase activity
SIL_RS05280	COG1234	tRNA 3'-trailer cleavage
SIL_RS05295	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SIL_RS05330	COG0488	(ABC) transporter
SIL_RS05340	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SIL_RS05345	COG0725	ABC transporter, periplasmic molybdate-binding protein
SIL_RS05350	COG0300	oxidoreductase activity
SIL_RS05355	COG3383	formate dehydrogenase (NAD+) activity
SIL_RS05370	COG0650	Formate hydrogenlyase subunit 4
SIL_RS05380	COG0651	ATP synthesis coupled electron transport
SIL_RS05385	COG0649	NAD binding
SIL_RS05390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIL_RS05395	COG0651	ATP synthesis coupled electron transport
SIL_RS05405	COG2897	thiosulfate sulfurtransferase activity
SIL_RS05410	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SIL_RS05430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SIL_RS05435	COG0157	Belongs to the NadC ModD family
SIL_RS05465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SIL_RS05475	COG0297	glycogen (starch) synthase activity
SIL_RS05485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SIL_RS05495	COG0469	pyruvate kinase activity
SIL_RS05510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SIL_RS05520	COG0528	UMP kinase activity
SIL_RS05530	COG1028	Short-chain dehydrogenase reductase Sdr
SIL_RS05545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SIL_RS05550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SIL_RS05560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SIL_RS05590	COG1110	DNA topoisomerase II activity
SIL_RS05630	COG0154	amidase activity
SIL_RS05645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SIL_RS05645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SIL_RS05700	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
SIL_RS05730	COG0252	asparaginase activity
SIL_RS05735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SIL_RS05765	COG1372	Participates in initiation and elongation during chromosome replication
SIL_RS05765	COG0719	Fe-S assembly protein
SIL_RS05770	COG0719	Fe-S assembly protein
SIL_RS05775	COG0396	ATPase activity
SIL_RS05795	COG0509	glycine decarboxylation via glycine cleavage system
SIL_RS05800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SIL_RS05810	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SIL_RS05830	COG0148	phosphopyruvate hydratase activity
SIL_RS05850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIL_RS05855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SIL_RS05870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SIL_RS05900	COG0644	oxidoreductase
SIL_RS05905	COG0525	valine-tRNA ligase activity
SIL_RS05910	COG0436	Aminotransferase
SIL_RS05915	COG0134	indole-3-glycerol-phosphate synthase activity
SIL_RS05920	COG0512	Glutamine amidotransferase of anthranilate synthase
SIL_RS05920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SIL_RS05925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SIL_RS05930	COG0135	phosphoribosylanthranilate isomerase activity
SIL_RS05940	COG0159	tryptophan synthase activity
SIL_RS05945	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SIL_RS05950	COG1254	Belongs to the acylphosphatase family
SIL_RS05955	COG1260	myo-inositol-1-phosphate synthase
SIL_RS05960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SIL_RS05960	COG0574	Belongs to the PEP-utilizing enzyme family
SIL_RS05980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SIL_RS05985	COG0460	homoserine dehydrogenase
SIL_RS05985	COG0527	aspartate kinase activity
SIL_RS06005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SIL_RS06040	COG0459	protein refolding
SIL_RS06085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SIL_RS06145	COG0315	cyclic pyranopterin monophosphate synthase activity
SIL_RS06150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SIL_RS06155	COG2255	four-way junction helicase activity
SIL_RS06160	COG1881	PFAM PEBP family protein
SIL_RS06165	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SIL_RS06200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SIL_RS06210	COG1047	Peptidyl-prolyl cis-trans
SIL_RS06225	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SIL_RS06240	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SIL_RS06280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SIL_RS06285	COG2264	protein methyltransferase activity
SIL_RS06290	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SIL_RS06300	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SIL_RS06345	COG1185	polyribonucleotide nucleotidyltransferase activity
SIL_RS06370	COG0322	excinuclease ABC activity
SIL_RS06375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SIL_RS06395	COG0473	3-isopropylmalate dehydrogenase activity
SIL_RS06400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SIL_RS06410	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SIL_RS06425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SIL_RS06430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SIL_RS06435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SIL_RS06440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SIL_RS06445	COG0255	Belongs to the universal ribosomal protein uL29 family
SIL_RS06455	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SIL_RS06460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SIL_RS06465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SIL_RS06475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SIL_RS06485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SIL_RS06490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SIL_RS06510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SIL_RS06545	COG0563	adenylate kinase activity
SIL_RS06650	COG1401	restriction endodeoxyribonuclease activity
SIL_RS06675	COG0577	efflux transmembrane transporter activity
SIL_RS06675	COG1136	(ABC) transporter
SIL_RS06685	COG0069	glutamate synthase activity
SIL_RS06690	COG0067	glutamate synthase
SIL_RS06705	COG0402	S-adenosylhomocysteine deaminase activity
SIL_RS06720	COG0303	'Molybdopterin
SIL_RS06735	COG2226	methyltransferase
SIL_RS06755	COG1321	iron dependent repressor
SIL_RS06765	COG2379	hydroxypyruvate reductase
SIL_RS06770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIL_RS06775	COG0009	L-threonylcarbamoyladenylate synthase
SIL_RS06790	COG0312	modulator of DNA gyrase
SIL_RS06795	COG0312	modulator of DNA gyrase
SIL_RS06800	COG0864	Transcriptional regulator
SIL_RS06810	COG0460	homoserine dehydrogenase
SIL_RS06825	COG1024	Enoyl-CoA hydratase
SIL_RS06865	COG1250	3-hydroxyacyl-CoA dehydrogenase
SIL_RS06875	COG0189	ligase activity
SIL_RS06885	COG0505	Belongs to the CarA family
SIL_RS06890	COG0165	Argininosuccinate lyase
SIL_RS06895	COG0137	argininosuccinate synthase activity
SIL_RS06910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SIL_RS06915	COG0151	Belongs to the GarS family
SIL_RS06920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SIL_RS06925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SIL_RS06935	COG0047	phosphoribosylformylglycinamidine synthase activity
SIL_RS06945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SIL_RS06950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIL_RS06950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIL_RS06955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SIL_RS06960	COG0602	queuosine metabolic process
SIL_RS06995	COG0284	orotidine-5'-phosphate decarboxylase activity
SIL_RS07000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SIL_RS07005	COG0540	Belongs to the ATCase OTCase family
SIL_RS07010	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
SIL_RS07025	COG0167	dihydroorotate dehydrogenase activity
SIL_RS07040	COG2095	MarC family integral membrane protein
SIL_RS07045	COG1522	sequence-specific DNA binding
SIL_RS07060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SIL_RS07065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SIL_RS07070	COG2151	metal-sulfur cluster biosynthetic enzyme
SIL_RS07080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SIL_RS07085	COG0140	phosphoribosyl-ATP diphosphatase activity
SIL_RS07085	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SIL_RS07090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SIL_RS07095	COG0107	imidazoleglycerol-phosphate synthase activity
SIL_RS07100	COG0131	Imidazoleglycerol-phosphate dehydratase
SIL_RS07105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SIL_RS07110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SIL_RS07115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SIL_RS07125	COG0495	leucyl-tRNA aminoacylation
SIL_RS07130	COG2096	Adenosyltransferase
SIL_RS07135	COG0037	tRNA processing
SIL_RS07145	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SIL_RS07170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SIL_RS07180	COG0028	Belongs to the TPP enzyme family
SIL_RS07190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SIL_RS07205	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SIL_RS07210	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SIL_RS07220	COG0442	prolyl-tRNA aminoacylation
SIL_RS07235	COG1394	ATPase activity, coupled to movement of substances
SIL_RS07245	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SIL_RS07265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIL_RS07295	COG0417	DNA replication proofreading
SIL_RS07310	COG0668	transmembrane transport
SIL_RS07320	COG0126	phosphoglycerate kinase activity
SIL_RS07330	COG0589	response to stress
SIL_RS07335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SIL_RS07355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SIL_RS07360	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SIL_RS07490	COG0495	leucyl-tRNA aminoacylation
SIL_RS07540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SIL_RS07550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SIL_RS07555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SIL_RS07560	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SIL_RS07575	COG0805	protein transport
SIL_RS07585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SIL_RS07610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SIL_RS07620	COG0556	nucleotide-excision repair
SIL_RS07625	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SIL_RS07635	COG3276	selenocysteine insertion sequence binding
SIL_RS07655	COG0351	phosphomethylpyrimidine kinase
SIL_RS07655	COG1992	Thiamine-phosphate synthase
SIL_RS07685	COG0489	protein tyrosine kinase activity
SIL_RS07705	COG1280	lysine exporter protein (LysE YggA)
SIL_RS07735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SIL_RS07745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SIL_RS07785	COG0423	glycine-tRNA ligase activity
SIL_RS07815	COG0163	prenyltransferase activity
SIL_RS07820	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SIL_RS07840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SIL_RS07845	COG0667	Aldo Keto reductase
SIL_RS07890	COG1110	DNA topoisomerase II activity
SIL_RS07895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIL_RS07900	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SIL_RS07945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SIL_RS07960	COG1797	cobyrinic acid a,c-diamide synthase activity
SIL_RS07980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SIL_RS07990	COG0402	S-adenosylhomocysteine deaminase activity
SIL_RS08010	COG1201	RNA secondary structure unwinding
SIL_RS08025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SIL_RS08030	COG2813	Specifically methylates the guanine in position
SIL_RS08040	COG1444	tRNA N-acetyltransferase activity
SIL_RS08085	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SIL_RS08090	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SIL_RS08100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SIL_RS08125	COG0475	glutathione-regulated potassium exporter activity
SIL_RS08135	COG0535	radical SAM domain protein
SIL_RS08140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SIL_RS08145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SIL_RS08145	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SIL_RS08155	COG0318	PFAM AMP-dependent synthetase and ligase
SIL_RS08160	COG3118	belongs to the thioredoxin family
SIL_RS08165	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SIL_RS08180	COG0302	gtp cyclohydrolase
SIL_RS08190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SIL_RS08205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SIL_RS08270	COG0552	protein localization to endoplasmic reticulum
SIL_RS08285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SIL_RS08305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SIL_RS08335	COG0301	tRNA thio-modification
SIL_RS08340	COG1260	myo-inositol-1-phosphate synthase
SIL_RS08345	COG1007	ATP synthesis coupled electron transport
SIL_RS08350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SIL_RS08355	COG0713	ATP synthesis coupled electron transport
SIL_RS08365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIL_RS08370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SIL_RS08375	COG0649	NAD binding
SIL_RS08380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIL_RS08390	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SIL_RS08410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SIL_RS08415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SIL_RS08455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SIL_RS08465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SIL_RS08470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SIL_RS08475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SIL_RS08480	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SIL_RS08490	COG3958	Transketolase
SIL_RS08495	COG3959	Transketolase, thiamine diphosphate binding domain
SIL_RS08500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SIL_RS08520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SIL_RS08530	COG1185	polyribonucleotide nucleotidyltransferase activity
SIL_RS08555	COG0477	Major facilitator Superfamily
SIL_RS08565	COG1121	(ABC) transporter
SIL_RS08570	COG1980	fructose-bisphosphate aldolase activity
SIL_RS08595	COG0459	protein refolding
SIL_RS08610	COG0124	histidyl-tRNA synthetase
SIL_RS08645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIL_RS08655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SIL_RS08695	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SIL_RS08730	COG1051	belongs to the nudix hydrolase family
SIL_RS08730	COG1056	cytidyltransferase-related domain
SIL_RS08745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SIL_RS08745	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SIL_RS08770	COG0077	Prephenate dehydratase
SIL_RS08770	COG1605	Chorismate mutase
SIL_RS08785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SIL_RS08800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SIL_RS08815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SIL_RS08830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SIL_RS08835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SIL_RS08850	COG0105	UTP biosynthetic process
SIL_RS08865	COG0085	RNA polymerase activity
SIL_RS08870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SIL_RS08875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SIL_RS08900	COG0049	tRNA binding
SIL_RS08905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SIL_RS08910	COG0051	transcription antitermination factor activity, RNA binding
SIL_RS08950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SIL_RS08955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SIL_RS08965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SIL_RS08985	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SIL_RS08990	COG0504	CTP synthase activity
SIL_RS09005	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SIL_RS09035	COG2078	PFAM AMMECR1 domain protein
SIL_RS09050	COG0717	Belongs to the dCTP deaminase family
SIL_RS09055	COG1793	dna ligase
SIL_RS09060	COG1793	dna ligase
SIL_RS09060	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SIL_RS09065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SIL_RS09090	COG0181	hydroxymethylbilane synthase activity
SIL_RS09095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SIL_RS09100	COG0113	porphobilinogen synthase activity
SIL_RS09105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SIL_RS09125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIL_RS09145	COG0585	pseudouridine synthase activity
SIL_RS09150	COG0017	Asparaginyl-tRNA synthetase
SIL_RS09165	COG0028	Belongs to the TPP enzyme family
SIL_RS09180	COG1122	ATPase activity
SIL_RS09215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SIL_RS09220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIL_RS09225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SIL_RS09230	COG0189	ligase activity
SIL_RS09245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SIL_RS09250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SIL_RS09265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SIL_RS09300	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SIL_RS09335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SIL_RS09340	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SIL_RS09390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SIL_RS09405	COG1201	RNA secondary structure unwinding
SIL_RS09410	COG0617	tRNA 3'-terminal CCA addition
SIL_RS09410	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SIL_RS09410	COG0517	IMP dehydrogenase activity
SIL_RS09435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SIL_RS09440	COG1058	Belongs to the CinA family
SIL_RS09440	COG1546	Belongs to the CinA family
SIL_RS09445	COG2267	carboxylic ester hydrolase activity
SIL_RS09460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SIL_RS09485	COG1078	dGTPase activity
SIL_RS09490	COG0561	phosphatase activity
SIL_RS09495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SIL_RS09510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SIL_RS09540	COG0456	acetyltransferase
SIL_RS09540	COG1214	PFAM Peptidase M22, glycoprotease
SIL_RS09555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SIL_RS09570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SIL_RS09575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SIL_RS09580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SIL_RS09590	COG0200	Binds to the 23S rRNA
SIL_RS09595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SIL_RS09600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SIL_RS09610	COG0052	Belongs to the universal ribosomal protein uS2 family
SIL_RS09615	COG1355	regulation of microtubule-based process
SIL_RS09630	COG1304	FMN binding
SIL_RS09685	COG1131	(ABC) transporter
SIL_RS09715	COG0084	hydrolase, TatD family'
SIL_RS09730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SIL_RS09770	COG1192	Involved in chromosome partitioning
SIL_RS09790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SIL_RS09790	COG3620	sequence-specific DNA binding
SIL_RS09790	COG0617	tRNA 3'-terminal CCA addition
SIL_RS09800	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SIL_RS09845	COG1201	RNA secondary structure unwinding
SIL_RS09855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SIL_RS09880	COG2860	membrane
SIL_RS09895	COG0123	including yeast histone deacetylase and acetoin utilization protein
SIL_RS09915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SIL_RS09920	COG0352	thiamine-phosphate diphosphorylase activity
SIL_RS09920	COG0351	phosphomethylpyrimidine kinase
SIL_RS09930	COG1215	transferase activity, transferring glycosyl groups
SIL_RS09980	COG0463	Glycosyl transferase, family 2
SIL_RS10000	COG1063	alcohol dehydrogenase
SIL_RS10020	COG0519	Catalyzes the synthesis of GMP from XMP
SIL_RS10020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SIL_RS10025	COG0501	Belongs to the peptidase M48B family
SIL_RS10030	COG0517	IMP dehydrogenase activity
SIL_RS10030	COG0516	GMP reductase activity
SIL_RS10040	COG1830	Aldolase
SIL_RS10065	COG0405	Gamma-glutamyltransferase
SIL_RS10080	COG1444	tRNA N-acetyltransferase activity
SIL_RS10095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SIL_RS10105	COG0656	L-ascorbic acid biosynthetic process
SIL_RS10120	COG0251	oxidation-reduction process
SIL_RS10125	COG0517	IMP dehydrogenase activity
SIL_RS10125	COG0617	tRNA 3'-terminal CCA addition
SIL_RS10125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SIL_RS10130	COG1063	alcohol dehydrogenase
SIL_RS10135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIL_RS10145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SIL_RS10155	COG4948	Mandelate Racemase Muconate Lactonizing
SIL_RS10160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIL_RS10165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SIL_RS10170	COG1012	belongs to the aldehyde dehydrogenase family
SIL_RS10180	COG0243	molybdopterin cofactor binding
SIL_RS10225	COG0833	amino acid
SIL_RS10230	COG0589	response to stress
SIL_RS10245	COG2814	Major facilitator Superfamily
SIL_RS10315	COG1733	regulation of RNA biosynthetic process
SIL_RS10325	COG0516	GMP reductase activity
SIL_RS10325	COG0517	IMP dehydrogenase activity
SIL_RS10330	COG1720	tRNA m6t6A37 methyltransferase activity
SIL_RS10365	COG0277	FAD linked oxidase domain protein
SIL_RS10370	COG0247	lactate metabolic process
SIL_RS10375	COG0095	Lipoate-protein ligase
SIL_RS10380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SIL_RS10395	COG0655	NAD(P)H dehydrogenase (quinone) activity
SIL_RS10420	COG0477	Major facilitator Superfamily
SIL_RS10430	COG1960	acyl-CoA dehydrogenase activity
SIL_RS10440	COG2271	Major facilitator Superfamily
SIL_RS10470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SIL_RS10490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIL_RS10500	COG1139	Iron-sulfur cluster binding protein
SIL_RS10505	COG2814	Major facilitator Superfamily
SIL_RS10520	COG4948	Mandelate Racemase Muconate Lactonizing
SIL_RS10530	COG0477	Major facilitator Superfamily
SIL_RS10535	COG2271	Major facilitator Superfamily
SIL_RS10540	COG0179	Fumarylacetoacetate (FAA) hydrolase
SIL_RS10550	COG2267	carboxylic ester hydrolase activity
SIL_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
SIL_RS10605	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SIL_RS10645	COG1122	ATPase activity
SIL_RS10685	COG0425	Belongs to the sulfur carrier protein TusA family
SIL_RS10705	COG1131	(ABC) transporter
SIL_RS10780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIL_RS10790	COG3842	ATPase activity
SIL_RS10795	COG0395	ABC-type sugar transport system, permease component
SIL_RS10810	COG0318	PFAM AMP-dependent synthetase and ligase
SIL_RS10845	COG0667	Aldo Keto reductase
SIL_RS10870	COG0673	inositol 2-dehydrogenase activity
SIL_RS10880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SIL_RS10885	COG0444	Belongs to the ABC transporter superfamily
SIL_RS10890	COG4608	Belongs to the ABC transporter superfamily
SIL_RS10905	COG3386	PFAM SMP-30 Gluconolaconase
SIL_RS10915	COG3250	beta-galactosidase activity
SIL_RS10920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIL_RS10930	COG1472	Belongs to the glycosyl hydrolase 3 family
SIL_RS10970	COG3408	Glycogen debranching enzyme
SIL_RS10995	COG1501	Belongs to the glycosyl hydrolase 31 family
SIL_RS11005	COG2723	6-phospho-beta-galactosidase activity
SIL_RS11025	COG0667	Aldo Keto reductase
SIL_RS11035	COG1132	(ABC) transporter
SIL_RS11055	COG0673	inositol 2-dehydrogenase activity
SIL_RS11070	COG1028	Short-chain dehydrogenase reductase Sdr
SIL_RS11090	COG0459	protein refolding
SIL_RS11095	COG4948	Mandelate Racemase Muconate Lactonizing
SIL_RS11100	COG1250	3-hydroxyacyl-CoA dehydrogenase
SIL_RS11105	COG1914	H( )-stimulated, divalent metal cation uptake system
SIL_RS11180	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SIL_RS11200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SIL_RS11215	COG2857	Cytochrome c1
SIL_RS11215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SIL_RS11270	COG0601	transmembrane transport
SIL_RS11275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SIL_RS11280	COG0444	Belongs to the ABC transporter superfamily
SIL_RS11285	COG4608	Belongs to the ABC transporter superfamily
SIL_RS11390	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SIL_RS11425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SIL_RS11430	COG1648	precorrin-2 dehydrogenase activity
SIL_RS11430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SIL_RS11435	COG2897	thiosulfate sulfurtransferase activity
SIL_RS11465	COG0667	Aldo Keto reductase
SIL_RS11490	COG3608	succinylglutamate desuccinylase aspartoacylase
SIL_RS11490	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SIL_RS11500	COG1960	acyl-CoA dehydrogenase activity
SIL_RS11505	COG0318	PFAM AMP-dependent synthetase and ligase
SIL_RS11520	COG1250	3-hydroxyacyl-CoA dehydrogenase
SIL_RS11530	COG0281	malic enzyme
SIL_RS11555	COG1584	GPR1 FUN34 yaaH family protein
SIL_RS11560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIL_RS11595	COG0477	Major facilitator Superfamily
SIL_RS11600	COG3842	ATPase activity
SIL_RS11605	COG0395	ABC-type sugar transport system, permease component
SIL_RS11660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIL_RS11700	COG3383	formate dehydrogenase (NAD+) activity
SIL_RS11710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SIL_RS11715	COG3848	Pyruvate phosphate dikinase
SIL_RS11715	COG0574	Belongs to the PEP-utilizing enzyme family
SIL_RS11725	COG0644	oxidoreductase
SIL_RS11730	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SIL_RS11735	COG1013	pyruvate-flavodoxin oxidoreductase activity
SIL_RS11740	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIL_RS11740	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SIL_RS11765	COG0318	PFAM AMP-dependent synthetase and ligase
SIL_RS11810	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SIL_RS11850	COG1063	alcohol dehydrogenase
SIL_RS11875	COG0243	molybdopterin cofactor binding
SIL_RS11880	COG0437	4 iron, 4 sulfur cluster binding
SIL_RS11935	COG0668	transmembrane transport
SIL_RS11940	COG0586	Pfam SNARE associated Golgi protein
SIL_RS11950	COG0022	dehydrogenase e1 component
SIL_RS11955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SIL_RS11960	COG0656	L-ascorbic acid biosynthetic process
SIL_RS11965	COG0589	response to stress
SIL_RS11975	COG0644	oxidoreductase
SIL_RS11990	COG0028	Belongs to the TPP enzyme family
SIL_RS12005	COG0402	S-adenosylhomocysteine deaminase activity
SIL_RS12025	COG0492	ferredoxin-NADP+ reductase activity
SIL_RS12035	COG2086	electron transfer activity
SIL_RS12045	COG1960	acyl-CoA dehydrogenase activity
SIL_RS12060	COG0437	4 iron, 4 sulfur cluster binding
SIL_RS12065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SIL_RS12070	COG1144	Oxidoreductase
SIL_RS12075	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIL_RS12080	COG1013	pyruvate-flavodoxin oxidoreductase activity
SIL_RS12085	COG0438	transferase activity, transferring glycosyl groups
SIL_RS12090	COG3387	PFAM Glycoside hydrolase 15-related
SIL_RS12145	COG3387	PFAM Glycoside hydrolase 15-related
SIL_RS12155	COG0517	IMP dehydrogenase activity
SIL_RS12165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIL_RS12225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIL_RS12235	COG2223	nitrite transmembrane transporter activity
SIL_RS12250	COG0395	ABC-type sugar transport system, permease component
SIL_RS12255	COG3842	ATPase activity
SIL_RS12290	COG0813	purine-nucleoside phosphorylase activity
SIL_RS12295	COG3386	PFAM SMP-30 Gluconolaconase
SIL_RS12300	COG2814	Major facilitator Superfamily
SIL_RS12325	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SIL_RS12345	COG4274	PFAM GYD family protein
SIL_RS12355	COG1506	peptidase
SIL_RS12355	COG4946	Tricorn protease homolog
SIL_RS12355	COG0823	Involved in the tonB-independent uptake of proteins
SIL_RS12370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIL_RS12420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SIL_RS12480	COG4608	Belongs to the ABC transporter superfamily
SIL_RS12485	COG0444	Belongs to the ABC transporter superfamily
SIL_RS12500	COG0601	transmembrane transport
SIL_RS12515	COG4948	Mandelate Racemase Muconate Lactonizing
SIL_RS12520	COG1028	Short-chain dehydrogenase reductase Sdr
SIL_RS12575	COG2217	Heavy metal translocating P-type atpase
SIL_RS12585	COG4555	ABC transporter
SIL_RS12610	COG1592	Rubrerythrin
SIL_RS12645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SIL_RS12695	COG0183	Belongs to the thiolase family
SIL_RS12705	COG1024	Enoyl-CoA hydratase
SIL_RS12730	COG0601	transmembrane transport
SIL_RS12735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SIL_RS12740	COG0444	Belongs to the ABC transporter superfamily
SIL_RS12745	COG4608	Belongs to the ABC transporter superfamily
SIL_RS12755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SIL_RS12760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SIL_RS12775	COG0438	transferase activity, transferring glycosyl groups
SIL_RS12795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SIL_RS12820	COG1131	(ABC) transporter
SIL_RS12825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SIL_RS12830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SIL_RS12835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SIL_RS12855	COG0675	Transposase, IS605 OrfB family
SIL_RS12865	COG0149	triose-phosphate isomerase activity
SIL_RS12880	COG0372	Belongs to the citrate synthase family
SIL_RS12885	COG0516	GMP reductase activity
SIL_RS12885	COG0517	IMP dehydrogenase activity
SIL_RS12890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SIL_RS12895	COG2079	MmgE PrpD family protein
SIL_RS12900	COG0039	L-malate dehydrogenase activity
SIL_RS12905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SIL_RS12935	COG0750	zinc metalloprotease
SIL_RS12955	COG1489	DNA binding
SIL_RS12985	COG0778	Nitroreductase
SIL_RS12990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIL_RS13115	COG0308	aminopeptidase N
SIL_RS13130	COG0561	phosphatase activity
SIL_RS13140	COG1011	Hydrolase
SIL_RS13155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SIL_RS13185	COG0494	nUDIX hydrolase
SIL_RS13195	COG3253	May function as heme-dependent peroxidase
SIL_RS13210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SIL_RS13240	COG2226	methyltransferase
SIL_RS13265	COG0538	isocitrate dehydrogenase activity
SIL_RS13285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SIL_RS13565	COG1216	Glycosyl transferase, family 2
SIL_RS13585	COG0438	transferase activity, transferring glycosyl groups
SIL_RS13685	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate