locus-tag	class	description
LS215_RS00020	COG2154	pterin-4-alpha-carbinolamine dehydratase
LS215_RS00100	COG1331	Highly conserved protein containing a thioredoxin domain
LS215_RS00110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LS215_RS00120	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LS215_RS00145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LS215_RS00160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LS215_RS00170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LS215_RS00175	COG2814	Major facilitator Superfamily
LS215_RS00185	COG0492	ferredoxin-NADP+ reductase activity
LS215_RS00255	COG0588	phosphoglycerate mutase activity
LS215_RS00275	COG1957	nucleoside hydrolase
LS215_RS00280	COG0735	belongs to the Fur family
LS215_RS00325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LS215_RS00325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LS215_RS00330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LS215_RS00335	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
LS215_RS00355	COG0596	Alpha beta hydrolase
LS215_RS00370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LS215_RS00410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LS215_RS00415	COG1573	uracil-dna glycosylase
LS215_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
LS215_RS00445	COG0215	cysteine-tRNA ligase activity
LS215_RS00450	COG2222	sugar isomerase
LS215_RS00460	COG0446	pyridine nucleotide-disulphide oxidoreductase
LS215_RS00470	COG0433	COG0433 Predicted ATPase
LS215_RS00480	COG1607	acyl-coa hydrolase
LS215_RS00490	COG1028	Short-chain dehydrogenase reductase Sdr
LS215_RS00495	COG0708	Exodeoxyribonuclease III
LS215_RS00535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LS215_RS00535	COG1648	precorrin-2 dehydrogenase activity
LS215_RS00545	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LS215_RS00565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LS215_RS00575	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
LS215_RS00815	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LS215_RS00820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LS215_RS00835	COG0189	ligase activity
LS215_RS00875	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LS215_RS00895	COG1053	succinate dehydrogenase
LS215_RS00915	COG2304	oxidoreductase activity
LS215_RS00920	COG0714	Associated with various cellular activities
LS215_RS00945	COG0083	homoserine kinase activity
LS215_RS00950	COG0626	cystathionine gamma-synthase activity
LS215_RS00990	COG0183	Belongs to the thiolase family
LS215_RS00995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LS215_RS01035	COG1215	transferase activity, transferring glycosyl groups
LS215_RS01040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LS215_RS01050	COG0351	phosphomethylpyrimidine kinase
LS215_RS01055	COG0314	molybdopterin synthase activity
LS215_RS01080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LS215_RS01090	COG1131	(ABC) transporter
LS215_RS01095	COG1668	transmembrane transport
LS215_RS01120	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LS215_RS01125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LS215_RS01155	COG0720	synthase
LS215_RS01180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LS215_RS01200	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LS215_RS01200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LS215_RS01210	COG0071	Belongs to the small heat shock protein (HSP20) family
LS215_RS01270	COG0402	S-adenosylhomocysteine deaminase activity
LS215_RS01295	COG0430	RNA-3'-phosphate cyclase activity
LS215_RS01305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LS215_RS01310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LS215_RS01315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LS215_RS01325	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
LS215_RS01330	COG5599	Phosphatase
LS215_RS01335	COG1515	deoxyribonuclease V activity
LS215_RS01340	COG1335	isochorismatase
LS215_RS01375	COG4581	dead DEAH box helicase
LS215_RS01385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LS215_RS01395	COG0439	Biotin carboxylase
LS215_RS01405	COG1116	anion transmembrane transporter activity
LS215_RS01415	COG0066	3-isopropylmalate dehydratase activity
LS215_RS01425	COG0415	Belongs to the DNA photolyase family
LS215_RS01460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LS215_RS01495	COG0045	succinate-CoA ligase (ADP-forming) activity
LS215_RS01510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LS215_RS01515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LS215_RS01545	COG0657	acetylesterase activity
LS215_RS01550	COG1063	alcohol dehydrogenase
LS215_RS01555	COG0183	Belongs to the thiolase family
LS215_RS01560	COG1960	acyl-CoA dehydrogenase activity
LS215_RS01565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LS215_RS01570	COG1028	Short-chain dehydrogenase reductase Sdr
LS215_RS01575	COG1063	alcohol dehydrogenase
LS215_RS01615	COG0318	PFAM AMP-dependent synthetase and ligase
LS215_RS01620	COG1960	acyl-CoA dehydrogenase activity
LS215_RS01625	COG1250	3-hydroxyacyl-CoA dehydrogenase
LS215_RS01630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LS215_RS01635	COG0477	Major facilitator Superfamily
LS215_RS01635	COG2814	Major facilitator Superfamily
LS215_RS01660	COG0657	acetylesterase activity
LS215_RS01670	COG0318	PFAM AMP-dependent synthetase and ligase
LS215_RS01680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LS215_RS01685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LS215_RS01785	COG0432	Pfam Uncharacterised protein family UPF0047
LS215_RS01790	COG1305	Transglutaminase-like
LS215_RS01800	COG1522	sequence-specific DNA binding
LS215_RS01805	COG1013	pyruvate-flavodoxin oxidoreductase activity
LS215_RS01810	COG0674	pyruvate-flavodoxin oxidoreductase activity
LS215_RS01825	COG1620	l-lactate permease
LS215_RS01855	COG0450	alkyl hydroperoxide reductase
LS215_RS01900	COG3573	Dehydrogenase
LS215_RS01920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LS215_RS01925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LS215_RS01935	COG2062	phosphohistidine phosphatase, SixA
LS215_RS01950	COG0674	pyruvate-flavodoxin oxidoreductase activity
LS215_RS02030	COG1012	belongs to the aldehyde dehydrogenase family
LS215_RS02075	COG3350	monooxygenase activity
LS215_RS02100	COG2151	metal-sulfur cluster biosynthetic enzyme
LS215_RS02105	COG0028	Belongs to the TPP enzyme family
LS215_RS02110	COG1741	Belongs to the pirin family
LS215_RS02125	COG1024	Enoyl-CoA hydratase
LS215_RS02135	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LS215_RS02150	COG1012	belongs to the aldehyde dehydrogenase family
LS215_RS02160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LS215_RS02165	COG4946	Tricorn protease homolog
LS215_RS02165	COG0793	Belongs to the peptidase S41A family
LS215_RS02215	COG0412	Dienelactone hydrolase
LS215_RS02265	COG2084	Dehydrogenase
LS215_RS02315	COG0598	Magnesium transport protein CorA
LS215_RS02375	COG0455	bacterial-type flagellum organization
LS215_RS02390	COG2050	protein possibly involved in aromatic compounds catabolism
LS215_RS02390	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LS215_RS02395	COG2301	Belongs to the HpcH HpaI aldolase family
LS215_RS02400	COG1802	Transcriptional regulator
LS215_RS02405	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LS215_RS02420	COG2721	sulfolactate sulfo-lyase activity
LS215_RS02425	COG2721	sulfolactate sulfo-lyase activity
LS215_RS02450	COG1131	(ABC) transporter
LS215_RS02455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LS215_RS02470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LS215_RS02485	COG0601	transmembrane transport
LS215_RS02495	COG0444	Belongs to the ABC transporter superfamily
LS215_RS02500	COG4608	Belongs to the ABC transporter superfamily
LS215_RS02530	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LS215_RS02530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LS215_RS02535	COG0675	Transposase, IS605 OrfB family
LS215_RS02555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LS215_RS02670	COG0535	radical SAM domain protein
LS215_RS02675	COG0535	radical SAM domain protein
LS215_RS02680	COG1012	belongs to the aldehyde dehydrogenase family
LS215_RS02905	COG1127	ABC transporter
LS215_RS03000	COG1216	Glycosyl transferase, family 2
LS215_RS03035	COG1215	transferase activity, transferring glycosyl groups
LS215_RS03045	COG0438	transferase activity, transferring glycosyl groups
LS215_RS03065	COG0438	transferase activity, transferring glycosyl groups
LS215_RS03080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LS215_RS03105	COG0175	sulfate reduction
LS215_RS03220	COG0675	Transposase, IS605 OrfB family
LS215_RS03230	COG1131	(ABC) transporter
LS215_RS03255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LS215_RS03260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LS215_RS03290	COG0675	Transposase, IS605 OrfB family
LS215_RS03310	COG1473	amidohydrolase
LS215_RS03360	COG1373	ATPase (AAA superfamily
LS215_RS03435	COG1337	RAMP superfamily
LS215_RS03570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LS215_RS03660	COG4638	Rieske (2fe-2S)
LS215_RS03685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LS215_RS03735	COG1129	ABC transporter
LS215_RS03740	COG1172	Belongs to the binding-protein-dependent transport system permease family
LS215_RS03750	COG1028	Short-chain dehydrogenase reductase Sdr
LS215_RS03755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LS215_RS03765	COG1063	alcohol dehydrogenase
LS215_RS03770	COG2814	Major facilitator Superfamily
LS215_RS03780	COG0508	dehydrogenase complex catalyzes the overall conversion of
LS215_RS03785	COG3199	ATP-NAD kinase
LS215_RS03790	COG0022	dehydrogenase e1 component
LS215_RS03795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LS215_RS03800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LS215_RS03810	COG0318	PFAM AMP-dependent synthetase and ligase
LS215_RS03815	COG1250	3-hydroxyacyl-CoA dehydrogenase
LS215_RS03840	COG0095	Lipoate-protein ligase
LS215_RS03845	COG1960	acyl-CoA dehydrogenase activity
LS215_RS03855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LS215_RS03880	COG2030	dehydratase
LS215_RS03885	COG0318	PFAM AMP-dependent synthetase and ligase
LS215_RS03890	COG4948	Mandelate Racemase Muconate Lactonizing
LS215_RS03895	COG2271	Major facilitator Superfamily
LS215_RS03910	COG4689	acetoacetate decarboxylase
LS215_RS03925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LS215_RS03940	COG0318	PFAM AMP-dependent synthetase and ligase
LS215_RS04045	COG0675	Transposase, IS605 OrfB family
LS215_RS04075	COG0675	Transposase, IS605 OrfB family
LS215_RS04185	COG0501	Belongs to the peptidase M48B family
LS215_RS04195	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
LS215_RS04210	COG0589	response to stress
LS215_RS04215	COG2151	metal-sulfur cluster biosynthetic enzyme
LS215_RS04315	COG2226	methyltransferase
LS215_RS04335	COG0045	succinate-CoA ligase (ADP-forming) activity
LS215_RS04335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LS215_RS04335	COG1042	CoA-binding domain protein
LS215_RS04355	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
LS215_RS04380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LS215_RS04400	COG0425	Belongs to the sulfur carrier protein TusA family
LS215_RS04410	COG1024	Enoyl-CoA hydratase
LS215_RS04480	COG1011	Hydrolase
LS215_RS04525	COG0477	Major facilitator Superfamily
LS215_RS04535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LS215_RS04540	COG1953	Uracil, thiamine, allantoin
LS215_RS04545	COG0531	amino acid
LS215_RS04550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LS215_RS04565	COG0477	Major facilitator Superfamily
LS215_RS04595	COG2368	4-hydroxyphenylacetate
LS215_RS04605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LS215_RS04610	COG2271	Major facilitator Superfamily
LS215_RS04620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LS215_RS04625	COG1960	acyl-CoA dehydrogenase activity
LS215_RS04680	COG2002	toxin-antitoxin pair type II binding
LS215_RS04685	COG0589	response to stress
LS215_RS04690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LS215_RS04735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LS215_RS04735	COG0517	IMP dehydrogenase activity
LS215_RS04765	COG0402	S-adenosylhomocysteine deaminase activity
LS215_RS04775	COG1136	(ABC) transporter
LS215_RS04775	COG0577	efflux transmembrane transporter activity
LS215_RS04815	COG2226	methyltransferase
LS215_RS04870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LS215_RS04875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LS215_RS04880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LS215_RS04910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LS215_RS04915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LS215_RS04925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LS215_RS04930	COG2224	Isocitrate lyase
LS215_RS04985	COG0463	Glycosyl transferase, family 2
LS215_RS05005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LS215_RS05010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LS215_RS05015	COG0463	Glycosyl transferase, family 2
LS215_RS05045	COG1216	Glycosyl transferase, family 2
LS215_RS05085	COG0438	transferase activity, transferring glycosyl groups
LS215_RS05095	COG0438	transferase activity, transferring glycosyl groups
LS215_RS05100	COG0438	transferase activity, transferring glycosyl groups
LS215_RS05105	COG1215	transferase activity, transferring glycosyl groups
LS215_RS05125	COG0438	transferase activity, transferring glycosyl groups
LS215_RS05130	COG1215	transferase activity, transferring glycosyl groups
LS215_RS05145	COG0438	transferase activity, transferring glycosyl groups
LS215_RS05170	COG3511	phospholipase C
LS215_RS05175	COG1091	dTDP-4-dehydrorhamnose reductase activity
LS215_RS05220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LS215_RS05310	COG0675	Transposase, IS605 OrfB family
LS215_RS05320	COG1028	Short-chain dehydrogenase reductase Sdr
LS215_RS05330	COG0477	Major facilitator Superfamily
LS215_RS05335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LS215_RS05365	COG4948	Mandelate Racemase Muconate Lactonizing
LS215_RS05370	COG2814	Major facilitator Superfamily
LS215_RS05400	COG1953	Uracil, thiamine, allantoin
LS215_RS05470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LS215_RS05515	COG0243	molybdopterin cofactor binding
LS215_RS05555	COG1725	Transcriptional regulator
LS215_RS05585	COG0318	PFAM AMP-dependent synthetase and ligase
LS215_RS05590	COG1960	acyl-CoA dehydrogenase activity
LS215_RS05645	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LS215_RS05665	COG2271	Major facilitator Superfamily
LS215_RS05675	COG0436	Aminotransferase
LS215_RS05710	COG1175	transmembrane transport
LS215_RS05715	COG3833	ABC-type maltose transport systems, permease component
LS215_RS05720	COG3842	ATPase activity
LS215_RS05730	COG2814	Major facilitator Superfamily
LS215_RS05780	COG1960	acyl-CoA dehydrogenase activity
LS215_RS05825	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
LS215_RS05830	COG1131	(ABC) transporter
LS215_RS05855	COG0475	glutathione-regulated potassium exporter activity
LS215_RS05870	COG2048	Heterodisulfide reductase, subunit B
LS215_RS05900	COG0425	Belongs to the sulfur carrier protein TusA family
LS215_RS05905	COG2210	Belongs to the sulfur carrier protein TusA family
LS215_RS05950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LS215_RS05960	COG0095	Lipoate-protein ligase
LS215_RS05965	COG1832	CoA-binding protein
LS215_RS05995	COG0509	glycine decarboxylation via glycine cleavage system
LS215_RS06005	COG2271	Major facilitator Superfamily
LS215_RS06040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LS215_RS06085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LS215_RS06095	COG1846	Transcriptional regulator
LS215_RS06100	COG1136	(ABC) transporter
LS215_RS06100	COG0577	efflux transmembrane transporter activity
LS215_RS06110	COG1136	(ABC) transporter
LS215_RS06115	COG0114	fumarate hydratase activity
LS215_RS06125	COG0517	IMP dehydrogenase activity
LS215_RS06130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LS215_RS06130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LS215_RS06135	COG0531	amino acid
LS215_RS06150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LS215_RS06155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LS215_RS06175	COG0509	glycine decarboxylation via glycine cleavage system
LS215_RS06210	COG0004	ammonium transporteR
LS215_RS06230	COG1185	polyribonucleotide nucleotidyltransferase activity
LS215_RS06275	COG1234	tRNA 3'-trailer cleavage
LS215_RS06290	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LS215_RS06335	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LS215_RS06340	COG0725	ABC transporter, periplasmic molybdate-binding protein
LS215_RS06345	COG0300	oxidoreductase activity
LS215_RS06350	COG3383	formate dehydrogenase (NAD+) activity
LS215_RS06365	COG0650	Formate hydrogenlyase subunit 4
LS215_RS06375	COG0651	ATP synthesis coupled electron transport
LS215_RS06380	COG0649	NAD binding
LS215_RS06385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LS215_RS06390	COG0651	ATP synthesis coupled electron transport
LS215_RS06400	COG2897	thiosulfate sulfurtransferase activity
LS215_RS06405	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LS215_RS06420	COG0028	Belongs to the TPP enzyme family
LS215_RS06425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LS215_RS06460	COG0395	ABC-type sugar transport system, permease component
LS215_RS06475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LS215_RS06480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LS215_RS06485	COG0157	Belongs to the NadC ModD family
LS215_RS06515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LS215_RS06525	COG0297	glycogen (starch) synthase activity
LS215_RS06535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LS215_RS06555	COG0469	pyruvate kinase activity
LS215_RS06570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LS215_RS06580	COG0528	UMP kinase activity
LS215_RS06590	COG1028	Short-chain dehydrogenase reductase Sdr
LS215_RS06605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LS215_RS06610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LS215_RS06620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LS215_RS06650	COG1110	DNA topoisomerase II activity
LS215_RS06690	COG0154	amidase activity
LS215_RS06705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LS215_RS06705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LS215_RS06760	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
LS215_RS06790	COG0252	asparaginase activity
LS215_RS06795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LS215_RS06825	COG1372	Participates in initiation and elongation during chromosome replication
LS215_RS06825	COG0719	Fe-S assembly protein
LS215_RS06830	COG0719	Fe-S assembly protein
LS215_RS06835	COG0396	ATPase activity
LS215_RS06855	COG0509	glycine decarboxylation via glycine cleavage system
LS215_RS06860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LS215_RS06870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LS215_RS06890	COG0148	phosphopyruvate hydratase activity
LS215_RS06910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LS215_RS06915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LS215_RS06930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LS215_RS06960	COG0644	oxidoreductase
LS215_RS06965	COG0525	valine-tRNA ligase activity
LS215_RS06970	COG0436	Aminotransferase
LS215_RS06975	COG0134	indole-3-glycerol-phosphate synthase activity
LS215_RS06980	COG0512	Glutamine amidotransferase of anthranilate synthase
LS215_RS06980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LS215_RS06985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LS215_RS06990	COG0135	phosphoribosylanthranilate isomerase activity
LS215_RS07000	COG0159	tryptophan synthase activity
LS215_RS07005	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
LS215_RS07010	COG1254	Belongs to the acylphosphatase family
LS215_RS07015	COG1260	myo-inositol-1-phosphate synthase
LS215_RS07020	COG0574	Belongs to the PEP-utilizing enzyme family
LS215_RS07020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LS215_RS07040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LS215_RS07045	COG0527	aspartate kinase activity
LS215_RS07045	COG0460	homoserine dehydrogenase
LS215_RS07065	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LS215_RS07100	COG0459	protein refolding
LS215_RS07195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LS215_RS07255	COG0315	cyclic pyranopterin monophosphate synthase activity
LS215_RS07260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LS215_RS07265	COG2255	four-way junction helicase activity
LS215_RS07270	COG1881	PFAM PEBP family protein
LS215_RS07275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LS215_RS07285	COG1063	alcohol dehydrogenase
LS215_RS07310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LS215_RS07315	COG0371	Dehydrogenase
LS215_RS07320	COG1047	Peptidyl-prolyl cis-trans
LS215_RS07340	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LS215_RS07350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LS215_RS07385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LS215_RS07390	COG2264	protein methyltransferase activity
LS215_RS07395	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LS215_RS07405	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LS215_RS07450	COG1185	polyribonucleotide nucleotidyltransferase activity
LS215_RS07475	COG0322	excinuclease ABC activity
LS215_RS07480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LS215_RS07500	COG0473	3-isopropylmalate dehydrogenase activity
LS215_RS07505	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LS215_RS07515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LS215_RS07530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LS215_RS07535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LS215_RS07540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LS215_RS07545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LS215_RS07550	COG0255	Belongs to the universal ribosomal protein uL29 family
LS215_RS07560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LS215_RS07565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LS215_RS07570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LS215_RS07580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LS215_RS07590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LS215_RS07595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LS215_RS07615	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LS215_RS07650	COG0563	adenylate kinase activity
LS215_RS07680	COG1136	(ABC) transporter
LS215_RS07690	COG0577	efflux transmembrane transporter activity
LS215_RS07690	COG1136	(ABC) transporter
LS215_RS07750	COG0069	glutamate synthase activity
LS215_RS07755	COG0067	glutamate synthase
LS215_RS07770	COG0402	S-adenosylhomocysteine deaminase activity
LS215_RS07785	COG0303	'Molybdopterin
LS215_RS07820	COG1321	iron dependent repressor
LS215_RS07830	COG2379	hydroxypyruvate reductase
LS215_RS07835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LS215_RS07840	COG0009	L-threonylcarbamoyladenylate synthase
LS215_RS07850	COG0312	modulator of DNA gyrase
LS215_RS07855	COG0312	modulator of DNA gyrase
LS215_RS07860	COG0864	Transcriptional regulator
LS215_RS07870	COG0460	homoserine dehydrogenase
LS215_RS07885	COG1024	Enoyl-CoA hydratase
LS215_RS07925	COG1250	3-hydroxyacyl-CoA dehydrogenase
LS215_RS07935	COG0189	ligase activity
LS215_RS07945	COG0505	Belongs to the CarA family
LS215_RS07950	COG0165	Argininosuccinate lyase
LS215_RS07955	COG0137	argininosuccinate synthase activity
LS215_RS07970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LS215_RS07975	COG0151	Belongs to the GarS family
LS215_RS07980	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LS215_RS07985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LS215_RS07995	COG0047	phosphoribosylformylglycinamidine synthase activity
LS215_RS08005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LS215_RS08010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LS215_RS08010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LS215_RS08015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LS215_RS08020	COG0602	queuosine metabolic process
LS215_RS08055	COG0284	orotidine-5'-phosphate decarboxylase activity
LS215_RS08060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LS215_RS08065	COG0540	Belongs to the ATCase OTCase family
LS215_RS08070	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LS215_RS08085	COG0167	dihydroorotate dehydrogenase activity
LS215_RS08100	COG2095	MarC family integral membrane protein
LS215_RS08105	COG1522	sequence-specific DNA binding
LS215_RS08120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LS215_RS08125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LS215_RS08130	COG2151	metal-sulfur cluster biosynthetic enzyme
LS215_RS08140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LS215_RS08145	COG0140	phosphoribosyl-ATP diphosphatase activity
LS215_RS08145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LS215_RS08150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LS215_RS08155	COG0107	imidazoleglycerol-phosphate synthase activity
LS215_RS08160	COG0131	Imidazoleglycerol-phosphate dehydratase
LS215_RS08165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LS215_RS08170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LS215_RS08175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LS215_RS08185	COG0495	leucyl-tRNA aminoacylation
LS215_RS08190	COG2096	Adenosyltransferase
LS215_RS08195	COG0037	tRNA processing
LS215_RS08205	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LS215_RS08230	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LS215_RS08240	COG0028	Belongs to the TPP enzyme family
LS215_RS08250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LS215_RS08265	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LS215_RS08270	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LS215_RS08280	COG0442	prolyl-tRNA aminoacylation
LS215_RS08295	COG1394	ATPase activity, coupled to movement of substances
LS215_RS08305	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
LS215_RS08325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LS215_RS08355	COG0417	DNA replication proofreading
LS215_RS08370	COG0668	transmembrane transport
LS215_RS08380	COG0126	phosphoglycerate kinase activity
LS215_RS08390	COG0589	response to stress
LS215_RS08395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LS215_RS08415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LS215_RS08420	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LS215_RS08560	COG0495	leucyl-tRNA aminoacylation
LS215_RS08610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LS215_RS08625	COG0581	inorganic phosphate transmembrane transporter activity
LS215_RS08640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LS215_RS08645	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LS215_RS08660	COG0805	protein transport
LS215_RS08670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LS215_RS08695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LS215_RS08705	COG0556	nucleotide-excision repair
LS215_RS08710	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LS215_RS08720	COG3276	selenocysteine insertion sequence binding
LS215_RS08740	COG1992	Thiamine-phosphate synthase
LS215_RS08740	COG0351	phosphomethylpyrimidine kinase
LS215_RS08770	COG0489	protein tyrosine kinase activity
LS215_RS08790	COG1280	lysine exporter protein (LysE YggA)
LS215_RS08820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LS215_RS08830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LS215_RS08870	COG0423	glycine-tRNA ligase activity
LS215_RS08900	COG0163	prenyltransferase activity
LS215_RS08905	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
LS215_RS08930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LS215_RS08935	COG0667	Aldo Keto reductase
LS215_RS08980	COG1110	DNA topoisomerase II activity
LS215_RS08985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LS215_RS08990	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
LS215_RS09005	COG0539	negative regulation of cytoplasmic translation
LS215_RS09015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LS215_RS09035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LS215_RS09050	COG1797	cobyrinic acid a,c-diamide synthase activity
LS215_RS09070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LS215_RS09080	COG0402	S-adenosylhomocysteine deaminase activity
LS215_RS09100	COG1201	RNA secondary structure unwinding
LS215_RS09115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LS215_RS09120	COG2813	Specifically methylates the guanine in position
LS215_RS09130	COG1444	tRNA N-acetyltransferase activity
LS215_RS09225	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LS215_RS09230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LS215_RS09240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LS215_RS09265	COG0475	glutathione-regulated potassium exporter activity
LS215_RS09275	COG0535	radical SAM domain protein
LS215_RS09280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LS215_RS09285	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LS215_RS09285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LS215_RS09295	COG0318	PFAM AMP-dependent synthetase and ligase
LS215_RS09300	COG3118	belongs to the thioredoxin family
LS215_RS09305	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LS215_RS09320	COG0302	gtp cyclohydrolase
LS215_RS09330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LS215_RS09345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LS215_RS09410	COG0552	protein localization to endoplasmic reticulum
LS215_RS09425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LS215_RS09435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LS215_RS09445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LS215_RS09470	COG0301	tRNA thio-modification
LS215_RS09475	COG1260	myo-inositol-1-phosphate synthase
LS215_RS09480	COG1007	ATP synthesis coupled electron transport
LS215_RS09485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LS215_RS09490	COG0713	ATP synthesis coupled electron transport
LS215_RS09500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LS215_RS09505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LS215_RS09510	COG0649	NAD binding
LS215_RS09515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LS215_RS09525	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LS215_RS09545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LS215_RS09550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LS215_RS09590	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LS215_RS09600	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LS215_RS09605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LS215_RS09610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LS215_RS09615	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LS215_RS09620	COG1605	Chorismate mutase
LS215_RS09620	COG0077	Prephenate dehydratase
LS215_RS09625	COG3958	Transketolase
LS215_RS09630	COG3959	Transketolase, thiamine diphosphate binding domain
LS215_RS09635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LS215_RS09655	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LS215_RS09665	COG1185	polyribonucleotide nucleotidyltransferase activity
LS215_RS09690	COG0477	Major facilitator Superfamily
LS215_RS09700	COG1121	(ABC) transporter
LS215_RS09705	COG1980	fructose-bisphosphate aldolase activity
LS215_RS09730	COG0459	protein refolding
LS215_RS09745	COG0124	histidyl-tRNA synthetase
LS215_RS09780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LS215_RS09790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LS215_RS09885	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
LS215_RS09920	COG1056	cytidyltransferase-related domain
LS215_RS09920	COG1051	belongs to the nudix hydrolase family
LS215_RS09935	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LS215_RS09935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LS215_RS09960	COG1605	Chorismate mutase
LS215_RS09960	COG0077	Prephenate dehydratase
LS215_RS09975	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LS215_RS09990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LS215_RS10005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LS215_RS10020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LS215_RS10025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LS215_RS10040	COG0105	UTP biosynthetic process
LS215_RS10055	COG0085	RNA polymerase activity
LS215_RS10060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LS215_RS10065	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LS215_RS10090	COG0049	tRNA binding
LS215_RS10095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LS215_RS10100	COG0051	transcription antitermination factor activity, RNA binding
LS215_RS10140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LS215_RS10145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LS215_RS10200	COG0675	Transposase, IS605 OrfB family
LS215_RS10410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LS215_RS10430	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
LS215_RS10435	COG0504	CTP synthase activity
LS215_RS10450	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
LS215_RS10480	COG2078	PFAM AMMECR1 domain protein
LS215_RS10495	COG0717	Belongs to the dCTP deaminase family
LS215_RS10500	COG1793	dna ligase
LS215_RS10505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LS215_RS10505	COG1793	dna ligase
LS215_RS10510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LS215_RS10535	COG0181	hydroxymethylbilane synthase activity
LS215_RS10540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LS215_RS10545	COG0113	porphobilinogen synthase activity
LS215_RS10550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LS215_RS10570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LS215_RS10590	COG0585	pseudouridine synthase activity
LS215_RS10595	COG0017	Asparaginyl-tRNA synthetase
LS215_RS10610	COG0028	Belongs to the TPP enzyme family
LS215_RS10625	COG1122	ATPase activity
LS215_RS10660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LS215_RS10665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LS215_RS10670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LS215_RS10675	COG0189	ligase activity
LS215_RS10690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LS215_RS10695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LS215_RS10710	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LS215_RS10755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LS215_RS10790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LS215_RS10810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LS215_RS10810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LS215_RS10845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LS215_RS10860	COG1201	RNA secondary structure unwinding
LS215_RS10865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LS215_RS10865	COG0517	IMP dehydrogenase activity
LS215_RS10865	COG0617	tRNA 3'-terminal CCA addition
LS215_RS10890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LS215_RS10895	COG1058	Belongs to the CinA family
LS215_RS10895	COG1546	Belongs to the CinA family
LS215_RS10900	COG2267	carboxylic ester hydrolase activity
LS215_RS10915	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LS215_RS10940	COG1078	dGTPase activity
LS215_RS10945	COG0561	phosphatase activity
LS215_RS10950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LS215_RS10965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LS215_RS10995	COG1214	PFAM Peptidase M22, glycoprotease
LS215_RS10995	COG0456	acetyltransferase
LS215_RS11010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LS215_RS11025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LS215_RS11030	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LS215_RS11035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LS215_RS11045	COG0200	Binds to the 23S rRNA
LS215_RS11050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LS215_RS11055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LS215_RS11065	COG0052	Belongs to the universal ribosomal protein uS2 family
LS215_RS11070	COG1355	regulation of microtubule-based process
LS215_RS11085	COG1304	FMN binding
LS215_RS11140	COG1131	(ABC) transporter
LS215_RS11170	COG0084	hydrolase, TatD family'
LS215_RS11185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LS215_RS11230	COG1192	Involved in chromosome partitioning
LS215_RS11250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LS215_RS11250	COG3620	sequence-specific DNA binding
LS215_RS11250	COG0617	tRNA 3'-terminal CCA addition
LS215_RS11260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LS215_RS11305	COG1201	RNA secondary structure unwinding
LS215_RS11315	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LS215_RS11340	COG2860	membrane
LS215_RS11355	COG0123	including yeast histone deacetylase and acetoin utilization protein
LS215_RS11375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LS215_RS11380	COG0352	thiamine-phosphate diphosphorylase activity
LS215_RS11380	COG0351	phosphomethylpyrimidine kinase
LS215_RS11390	COG1215	transferase activity, transferring glycosyl groups
LS215_RS11440	COG0463	Glycosyl transferase, family 2
LS215_RS11460	COG1063	alcohol dehydrogenase
LS215_RS11480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LS215_RS11480	COG0519	Catalyzes the synthesis of GMP from XMP
LS215_RS11485	COG0501	Belongs to the peptidase M48B family
LS215_RS11490	COG0516	GMP reductase activity
LS215_RS11490	COG0517	IMP dehydrogenase activity
LS215_RS11500	COG1830	Aldolase
LS215_RS11525	COG0405	Gamma-glutamyltransferase
LS215_RS11540	COG1444	tRNA N-acetyltransferase activity
LS215_RS11555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LS215_RS11565	COG0656	L-ascorbic acid biosynthetic process
LS215_RS11580	COG0251	oxidation-reduction process
LS215_RS11585	COG0517	IMP dehydrogenase activity
LS215_RS11585	COG0516	GMP reductase activity
LS215_RS11590	COG1063	alcohol dehydrogenase
LS215_RS11595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LS215_RS11605	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LS215_RS11615	COG4948	Mandelate Racemase Muconate Lactonizing
LS215_RS11620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LS215_RS11625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LS215_RS11630	COG1012	belongs to the aldehyde dehydrogenase family
LS215_RS11640	COG0243	molybdopterin cofactor binding
LS215_RS11680	COG0833	amino acid
LS215_RS11685	COG0589	response to stress
LS215_RS11690	COG2815	serine threonine protein kinase
LS215_RS11690	COG0515	serine threonine protein kinase
LS215_RS11700	COG2814	Major facilitator Superfamily
LS215_RS11780	COG1733	regulation of RNA biosynthetic process
LS215_RS11790	COG0517	IMP dehydrogenase activity
LS215_RS11790	COG0516	GMP reductase activity
LS215_RS11795	COG1720	tRNA m6t6A37 methyltransferase activity
LS215_RS11835	COG0277	FAD linked oxidase domain protein
LS215_RS11840	COG0247	lactate metabolic process
LS215_RS11845	COG0095	Lipoate-protein ligase
LS215_RS11850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LS215_RS11865	COG0655	NAD(P)H dehydrogenase (quinone) activity
LS215_RS11895	COG0477	Major facilitator Superfamily
LS215_RS11905	COG1960	acyl-CoA dehydrogenase activity
LS215_RS11915	COG2271	Major facilitator Superfamily
LS215_RS11945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LS215_RS11970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LS215_RS11980	COG1139	Iron-sulfur cluster binding protein
LS215_RS11985	COG2814	Major facilitator Superfamily
LS215_RS12000	COG4948	Mandelate Racemase Muconate Lactonizing
LS215_RS12015	COG2271	Major facilitator Superfamily
LS215_RS12020	COG0179	Fumarylacetoacetate (FAA) hydrolase
LS215_RS12030	COG2267	carboxylic ester hydrolase activity
LS215_RS12040	COG1028	Short-chain dehydrogenase reductase Sdr
LS215_RS12085	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LS215_RS12125	COG1122	ATPase activity
LS215_RS12165	COG0425	Belongs to the sulfur carrier protein TusA family
LS215_RS12185	COG1136	(ABC) transporter
LS215_RS12255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LS215_RS12265	COG3842	ATPase activity
LS215_RS12270	COG0395	ABC-type sugar transport system, permease component
LS215_RS12285	COG0318	PFAM AMP-dependent synthetase and ligase
LS215_RS12325	COG0667	Aldo Keto reductase
LS215_RS12350	COG0673	inositol 2-dehydrogenase activity
LS215_RS12360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LS215_RS12365	COG0444	Belongs to the ABC transporter superfamily
LS215_RS12370	COG4608	Belongs to the ABC transporter superfamily
LS215_RS12400	COG3250	beta-galactosidase activity
LS215_RS12405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LS215_RS12410	COG1472	Belongs to the glycosyl hydrolase 3 family
LS215_RS12470	COG3408	Glycogen debranching enzyme
LS215_RS12495	COG1501	Belongs to the glycosyl hydrolase 31 family
LS215_RS12505	COG2723	6-phospho-beta-galactosidase activity
LS215_RS12535	COG0667	Aldo Keto reductase
LS215_RS12545	COG1132	(ABC) transporter
LS215_RS12565	COG0673	inositol 2-dehydrogenase activity
LS215_RS12580	COG1028	Short-chain dehydrogenase reductase Sdr
LS215_RS12595	COG0459	protein refolding
LS215_RS12600	COG4948	Mandelate Racemase Muconate Lactonizing
LS215_RS12605	COG1250	3-hydroxyacyl-CoA dehydrogenase
LS215_RS12610	COG1914	H( )-stimulated, divalent metal cation uptake system
LS215_RS12690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LS215_RS12715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LS215_RS12730	COG2857	Cytochrome c1
LS215_RS12730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LS215_RS12780	COG0601	transmembrane transport
LS215_RS12785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LS215_RS12790	COG0444	Belongs to the ABC transporter superfamily
LS215_RS12795	COG4608	Belongs to the ABC transporter superfamily
LS215_RS12875	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
LS215_RS12910	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LS215_RS12920	COG2897	thiosulfate sulfurtransferase activity
LS215_RS12950	COG0667	Aldo Keto reductase
LS215_RS12970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LS215_RS12970	COG3608	succinylglutamate desuccinylase aspartoacylase
LS215_RS12980	COG1960	acyl-CoA dehydrogenase activity
LS215_RS12985	COG0318	PFAM AMP-dependent synthetase and ligase
LS215_RS13000	COG1250	3-hydroxyacyl-CoA dehydrogenase
LS215_RS13010	COG0281	malic enzyme
LS215_RS13035	COG1584	GPR1 FUN34 yaaH family protein
LS215_RS13040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LS215_RS13075	COG0477	Major facilitator Superfamily
LS215_RS13120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LS215_RS13160	COG3383	formate dehydrogenase (NAD+) activity
LS215_RS13170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LS215_RS13175	COG3848	Pyruvate phosphate dikinase
LS215_RS13175	COG0574	Belongs to the PEP-utilizing enzyme family
LS215_RS13230	COG0644	oxidoreductase
LS215_RS13235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LS215_RS13240	COG1013	pyruvate-flavodoxin oxidoreductase activity
LS215_RS13245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LS215_RS13245	COG0674	pyruvate-flavodoxin oxidoreductase activity
LS215_RS13275	COG0318	PFAM AMP-dependent synthetase and ligase
LS215_RS13310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LS215_RS13345	COG1063	alcohol dehydrogenase
LS215_RS13370	COG0243	molybdopterin cofactor binding
LS215_RS13375	COG0437	4 iron, 4 sulfur cluster binding
LS215_RS13455	COG0586	Pfam SNARE associated Golgi protein
LS215_RS13465	COG2002	toxin-antitoxin pair type II binding
LS215_RS13470	COG0022	dehydrogenase e1 component
LS215_RS13475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LS215_RS13480	COG0656	L-ascorbic acid biosynthetic process
LS215_RS13485	COG0589	response to stress
LS215_RS13495	COG0644	oxidoreductase
LS215_RS13510	COG0028	Belongs to the TPP enzyme family
LS215_RS13525	COG0402	S-adenosylhomocysteine deaminase activity
LS215_RS13550	COG0492	ferredoxin-NADP+ reductase activity
LS215_RS13560	COG2086	electron transfer activity
LS215_RS13570	COG1960	acyl-CoA dehydrogenase activity
LS215_RS13585	COG0437	4 iron, 4 sulfur cluster binding
LS215_RS13590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LS215_RS13595	COG1144	Oxidoreductase
LS215_RS13600	COG0674	pyruvate-flavodoxin oxidoreductase activity
LS215_RS13605	COG1013	pyruvate-flavodoxin oxidoreductase activity
LS215_RS13610	COG0438	transferase activity, transferring glycosyl groups
LS215_RS13615	COG3387	PFAM Glycoside hydrolase 15-related
LS215_RS13670	COG3387	PFAM Glycoside hydrolase 15-related
LS215_RS13680	COG0517	IMP dehydrogenase activity
LS215_RS13690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LS215_RS13755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LS215_RS13780	COG0395	ABC-type sugar transport system, permease component
LS215_RS13785	COG3842	ATPase activity
LS215_RS13815	COG0813	purine-nucleoside phosphorylase activity
LS215_RS13820	COG3386	PFAM SMP-30 Gluconolaconase
LS215_RS13825	COG2814	Major facilitator Superfamily
LS215_RS13855	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
LS215_RS13875	COG4274	PFAM GYD family protein
LS215_RS13885	COG0823	Involved in the tonB-independent uptake of proteins
LS215_RS13885	COG4946	Tricorn protease homolog
LS215_RS13885	COG1506	peptidase
LS215_RS13900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LS215_RS13985	COG4608	Belongs to the ABC transporter superfamily
LS215_RS13990	COG0444	Belongs to the ABC transporter superfamily
LS215_RS14005	COG0601	transmembrane transport
LS215_RS14020	COG4948	Mandelate Racemase Muconate Lactonizing
LS215_RS14025	COG1028	Short-chain dehydrogenase reductase Sdr
LS215_RS14080	COG2217	Heavy metal translocating P-type atpase
LS215_RS14090	COG4555	ABC transporter
LS215_RS14120	COG1592	Rubrerythrin
LS215_RS14155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LS215_RS14205	COG0183	Belongs to the thiolase family
LS215_RS14215	COG1024	Enoyl-CoA hydratase
LS215_RS14230	COG0531	amino acid
LS215_RS14265	COG0601	transmembrane transport
LS215_RS14270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LS215_RS14275	COG0444	Belongs to the ABC transporter superfamily
LS215_RS14280	COG4608	Belongs to the ABC transporter superfamily
LS215_RS14290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LS215_RS14295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LS215_RS14310	COG0438	transferase activity, transferring glycosyl groups
LS215_RS14330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LS215_RS14355	COG1131	(ABC) transporter
LS215_RS14365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LS215_RS14370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LS215_RS14390	COG0149	triose-phosphate isomerase activity
LS215_RS14405	COG0372	Belongs to the citrate synthase family
LS215_RS14410	COG0517	IMP dehydrogenase activity
LS215_RS14410	COG0516	GMP reductase activity
LS215_RS14415	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LS215_RS14420	COG2079	MmgE PrpD family protein
LS215_RS14425	COG0039	L-malate dehydrogenase activity
LS215_RS14430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LS215_RS14460	COG0750	zinc metalloprotease
LS215_RS14480	COG1489	DNA binding
LS215_RS14510	COG0778	Nitroreductase
LS215_RS14515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LS215_RS14655	COG0561	phosphatase activity
LS215_RS14665	COG1011	Hydrolase
LS215_RS14680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LS215_RS14715	COG0494	nUDIX hydrolase
LS215_RS14725	COG3253	May function as heme-dependent peroxidase
LS215_RS14740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LS215_RS14770	COG2226	methyltransferase
LS215_RS14795	COG0538	isocitrate dehydrogenase activity
LS215_RS15145	COG0393	Putative heavy-metal-binding
LS215_RS15220	COG1305	Transglutaminase-like
LS215_RS15275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LS215_RS15445	COG1131	(ABC) transporter