locus-tag	class	description
M1425_RS00020	COG2154	pterin-4-alpha-carbinolamine dehydratase
M1425_RS00100	COG1331	Highly conserved protein containing a thioredoxin domain
M1425_RS00110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1425_RS00120	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
M1425_RS00145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1425_RS00160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1425_RS00170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1425_RS00175	COG2814	Major facilitator Superfamily
M1425_RS00185	COG0492	ferredoxin-NADP+ reductase activity
M1425_RS00255	COG0588	phosphoglycerate mutase activity
M1425_RS00275	COG1957	nucleoside hydrolase
M1425_RS00280	COG0735	belongs to the Fur family
M1425_RS00325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1425_RS00325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1425_RS00330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1425_RS00335	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
M1425_RS00355	COG0596	Alpha beta hydrolase
M1425_RS00365	COG1703	isobutyryl-CoA mutase activity
M1425_RS00370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M1425_RS00410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1425_RS00415	COG1573	uracil-dna glycosylase
M1425_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
M1425_RS00445	COG0215	cysteine-tRNA ligase activity
M1425_RS00450	COG2222	sugar isomerase
M1425_RS00460	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1425_RS00470	COG0433	COG0433 Predicted ATPase
M1425_RS00480	COG1607	acyl-coa hydrolase
M1425_RS00490	COG1028	Short-chain dehydrogenase reductase Sdr
M1425_RS00495	COG0708	Exodeoxyribonuclease III
M1425_RS00500	COG0515	serine threonine protein kinase
M1425_RS00500	COG2815	serine threonine protein kinase
M1425_RS00535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1425_RS00535	COG1648	precorrin-2 dehydrogenase activity
M1425_RS00545	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
M1425_RS00565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1425_RS00575	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
M1425_RS00660	COG1063	alcohol dehydrogenase
M1425_RS00690	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M1425_RS00695	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M1425_RS00710	COG0189	ligase activity
M1425_RS00750	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M1425_RS00770	COG1053	succinate dehydrogenase
M1425_RS00790	COG2304	oxidoreductase activity
M1425_RS00795	COG0714	Associated with various cellular activities
M1425_RS00815	COG0083	homoserine kinase activity
M1425_RS00820	COG0626	cystathionine gamma-synthase activity
M1425_RS00860	COG0183	Belongs to the thiolase family
M1425_RS00865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1425_RS00905	COG1215	transferase activity, transferring glycosyl groups
M1425_RS00910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1425_RS00920	COG0351	phosphomethylpyrimidine kinase
M1425_RS00925	COG0314	molybdopterin synthase activity
M1425_RS00950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M1425_RS00960	COG1131	(ABC) transporter
M1425_RS00965	COG1668	transmembrane transport
M1425_RS00990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M1425_RS00995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1425_RS01025	COG0720	synthase
M1425_RS01040	COG0492	ferredoxin-NADP+ reductase activity
M1425_RS01050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1425_RS01070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M1425_RS01070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M1425_RS01080	COG0071	Belongs to the small heat shock protein (HSP20) family
M1425_RS01140	COG0402	S-adenosylhomocysteine deaminase activity
M1425_RS01165	COG0430	RNA-3'-phosphate cyclase activity
M1425_RS01180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1425_RS01185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1425_RS01195	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M1425_RS01205	COG1515	deoxyribonuclease V activity
M1425_RS01210	COG1335	isochorismatase
M1425_RS01245	COG4581	dead DEAH box helicase
M1425_RS01255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1425_RS01265	COG0439	Biotin carboxylase
M1425_RS01275	COG1116	anion transmembrane transporter activity
M1425_RS01285	COG0066	3-isopropylmalate dehydratase activity
M1425_RS01290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M1425_RS01295	COG0415	Belongs to the DNA photolyase family
M1425_RS01330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1425_RS01345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1425_RS01350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1425_RS01365	COG0045	succinate-CoA ligase (ADP-forming) activity
M1425_RS01415	COG0657	acetylesterase activity
M1425_RS01420	COG1063	alcohol dehydrogenase
M1425_RS01425	COG0183	Belongs to the thiolase family
M1425_RS01430	COG1960	acyl-CoA dehydrogenase activity
M1425_RS01435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1425_RS01440	COG1028	Short-chain dehydrogenase reductase Sdr
M1425_RS01445	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1425_RS01485	COG0318	PFAM AMP-dependent synthetase and ligase
M1425_RS01490	COG1960	acyl-CoA dehydrogenase activity
M1425_RS01495	COG1024	Enoyl-CoA hydratase
M1425_RS01500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1425_RS01505	COG0477	Major facilitator Superfamily
M1425_RS01505	COG2814	Major facilitator Superfamily
M1425_RS01535	COG0657	acetylesterase activity
M1425_RS01545	COG0318	PFAM AMP-dependent synthetase and ligase
M1425_RS01555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M1425_RS01560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1425_RS01575	COG2814	Major facilitator Superfamily
M1425_RS01575	COG0477	Major facilitator Superfamily
M1425_RS01685	COG0432	Pfam Uncharacterised protein family UPF0047
M1425_RS01690	COG1305	Transglutaminase-like
M1425_RS01700	COG1522	sequence-specific DNA binding
M1425_RS01705	COG1013	pyruvate-flavodoxin oxidoreductase activity
M1425_RS01710	COG0674	pyruvate-flavodoxin oxidoreductase activity
M1425_RS01725	COG1620	l-lactate permease
M1425_RS01730	COG1487	ribonuclease activity
M1425_RS01740	COG2226	methyltransferase
M1425_RS01755	COG0450	alkyl hydroperoxide reductase
M1425_RS01815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M1425_RS01820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M1425_RS01830	COG2062	phosphohistidine phosphatase, SixA
M1425_RS01845	COG0674	pyruvate-flavodoxin oxidoreductase activity
M1425_RS01890	COG0277	FAD linked oxidase domain protein
M1425_RS01935	COG1741	Belongs to the pirin family
M1425_RS01950	COG1024	Enoyl-CoA hydratase
M1425_RS01960	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
M1425_RS01995	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M1425_RS01995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1425_RS02005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M1425_RS02045	COG1017	nitric oxide dioxygenase activity
M1425_RS02070	COG4608	Belongs to the ABC transporter superfamily
M1425_RS02075	COG0444	Belongs to the ABC transporter superfamily
M1425_RS02085	COG0601	transmembrane transport
M1425_RS02100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1425_RS02115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1425_RS02120	COG1131	(ABC) transporter
M1425_RS02145	COG2721	sulfolactate sulfo-lyase activity
M1425_RS02150	COG2721	sulfolactate sulfo-lyase activity
M1425_RS02165	COG1802	Transcriptional regulator
M1425_RS02170	COG2301	Belongs to the HpcH HpaI aldolase family
M1425_RS02175	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M1425_RS02175	COG2050	protein possibly involved in aromatic compounds catabolism
M1425_RS02185	COG0598	Magnesium transport protein CorA
M1425_RS02205	COG2084	Dehydrogenase
M1425_RS02315	COG0412	Dienelactone hydrolase
M1425_RS02355	COG4946	Tricorn protease homolog
M1425_RS02355	COG0793	Belongs to the peptidase S41A family
M1425_RS02360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1425_RS02430	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M1425_RS02455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M1425_RS02525	COG1960	acyl-CoA dehydrogenase activity
M1425_RS02530	COG0318	PFAM AMP-dependent synthetase and ligase
M1425_RS02545	COG2814	Major facilitator Superfamily
M1425_RS02560	COG1725	Transcriptional regulator
M1425_RS02600	COG0243	molybdopterin cofactor binding
M1425_RS02645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1425_RS02725	COG1953	Uracil, thiamine, allantoin
M1425_RS02765	COG2814	Major facilitator Superfamily
M1425_RS02770	COG4948	Mandelate Racemase Muconate Lactonizing
M1425_RS02800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1425_RS02805	COG0477	Major facilitator Superfamily
M1425_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
M1425_RS02950	COG1401	restriction endodeoxyribonuclease activity
M1425_RS02970	COG1091	dTDP-4-dehydrorhamnose reductase activity
M1425_RS03000	COG0438	transferase activity, transferring glycosyl groups
M1425_RS03015	COG0463	Glycosyl transferase, family 2
M1425_RS03020	COG0438	transferase activity, transferring glycosyl groups
M1425_RS03040	COG1215	transferase activity, transferring glycosyl groups
M1425_RS03045	COG0438	transferase activity, transferring glycosyl groups
M1425_RS03050	COG0438	transferase activity, transferring glycosyl groups
M1425_RS03060	COG0438	transferase activity, transferring glycosyl groups
M1425_RS03105	COG1216	Glycosyl transferase, family 2
M1425_RS03140	COG0463	Glycosyl transferase, family 2
M1425_RS03160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1425_RS03165	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M1425_RS03185	COG0463	Glycosyl transferase, family 2
M1425_RS03235	COG2224	Isocitrate lyase
M1425_RS03240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1425_RS03250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1425_RS03255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1425_RS03265	COG2146	nitrite reductase [NAD(P)H] activity
M1425_RS03265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M1425_RS03290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1425_RS03295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1425_RS03300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1425_RS03345	COG1960	acyl-CoA dehydrogenase activity
M1425_RS03350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1425_RS03360	COG2271	Major facilitator Superfamily
M1425_RS03365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1425_RS03375	COG2368	4-hydroxyphenylacetate
M1425_RS03420	COG0477	Major facilitator Superfamily
M1425_RS03445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1425_RS03450	COG0531	amino acid
M1425_RS03455	COG1953	Uracil, thiamine, allantoin
M1425_RS03460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1425_RS03470	COG0477	Major facilitator Superfamily
M1425_RS03520	COG1011	Hydrolase
M1425_RS03575	COG0425	Belongs to the sulfur carrier protein TusA family
M1425_RS03610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1425_RS03610	COG1042	CoA-binding domain protein
M1425_RS03610	COG0045	succinate-CoA ligase (ADP-forming) activity
M1425_RS03630	COG2226	methyltransferase
M1425_RS03645	COG0577	efflux transmembrane transporter activity
M1425_RS03715	COG2151	metal-sulfur cluster biosynthetic enzyme
M1425_RS03720	COG0589	response to stress
M1425_RS03735	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M1425_RS03745	COG0501	Belongs to the peptidase M48B family
M1425_RS03860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1425_RS03920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M1425_RS03945	COG1073	alpha beta
M1425_RS03955	COG0318	PFAM AMP-dependent synthetase and ligase
M1425_RS03970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1425_RS03985	COG4689	acetoacetate decarboxylase
M1425_RS04000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1425_RS04010	COG2271	Major facilitator Superfamily
M1425_RS04015	COG4948	Mandelate Racemase Muconate Lactonizing
M1425_RS04020	COG0318	PFAM AMP-dependent synthetase and ligase
M1425_RS04025	COG2030	dehydratase
M1425_RS04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1425_RS04060	COG1960	acyl-CoA dehydrogenase activity
M1425_RS04065	COG0095	Lipoate-protein ligase
M1425_RS04080	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1425_RS04085	COG0318	PFAM AMP-dependent synthetase and ligase
M1425_RS04105	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M1425_RS04110	COG1140	nitrate reductase beta subunit
M1425_RS04115	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M1425_RS04120	COG2181	nitrate reductase activity
M1425_RS04150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1425_RS04155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1425_RS04160	COG0022	dehydrogenase e1 component
M1425_RS04165	COG3199	ATP-NAD kinase
M1425_RS04170	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1425_RS04210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1425_RS04260	COG1203	CRISPR-associated helicase, Cas3
M1425_RS04445	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M1425_RS04480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1425_RS04520	COG1373	ATPase (AAA superfamily
M1425_RS04570	COG1473	amidohydrolase
M1425_RS04595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M1425_RS04670	COG0598	Magnesium transport protein CorA
M1425_RS04700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1425_RS04720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M1425_RS04725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M1425_RS04740	COG1131	(ABC) transporter
M1425_RS04775	COG0675	Transposase, IS605 OrfB family
M1425_RS04845	COG1216	Glycosyl transferase, family 2
M1425_RS04845	COG1442	glycosyl transferase family 8
M1425_RS05140	COG0535	radical SAM domain protein
M1425_RS05145	COG0535	radical SAM domain protein
M1425_RS05150	COG1012	belongs to the aldehyde dehydrogenase family
M1425_RS05185	COG2271	Major facilitator Superfamily
M1425_RS05230	COG1175	transmembrane transport
M1425_RS05235	COG3833	ABC-type maltose transport systems, permease component
M1425_RS05240	COG3842	ATPase activity
M1425_RS05250	COG2814	Major facilitator Superfamily
M1425_RS05280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M1425_RS05300	COG1960	acyl-CoA dehydrogenase activity
M1425_RS05335	COG0477	Major facilitator Superfamily
M1425_RS05340	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
M1425_RS05345	COG1131	(ABC) transporter
M1425_RS05370	COG0475	glutathione-regulated potassium exporter activity
M1425_RS05385	COG2048	Heterodisulfide reductase, subunit B
M1425_RS05415	COG0425	Belongs to the sulfur carrier protein TusA family
M1425_RS05420	COG2210	Belongs to the sulfur carrier protein TusA family
M1425_RS05465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M1425_RS05475	COG0095	Lipoate-protein ligase
M1425_RS05480	COG1832	CoA-binding protein
M1425_RS05510	COG0509	glycine decarboxylation via glycine cleavage system
M1425_RS05520	COG2271	Major facilitator Superfamily
M1425_RS05560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1425_RS05605	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1425_RS05615	COG1846	Transcriptional regulator
M1425_RS05620	COG1136	(ABC) transporter
M1425_RS05620	COG0577	efflux transmembrane transporter activity
M1425_RS05630	COG1136	(ABC) transporter
M1425_RS05635	COG0114	fumarate hydratase activity
M1425_RS05645	COG0517	IMP dehydrogenase activity
M1425_RS05650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1425_RS05650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1425_RS05655	COG0531	amino acid
M1425_RS05665	COG2005	Transcriptional regulator
M1425_RS05670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1425_RS05675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M1425_RS05695	COG0509	glycine decarboxylation via glycine cleavage system
M1425_RS05735	COG0004	ammonium transporteR
M1425_RS05755	COG1185	polyribonucleotide nucleotidyltransferase activity
M1425_RS05800	COG1234	tRNA 3'-trailer cleavage
M1425_RS05815	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M1425_RS05850	COG0488	(ABC) transporter
M1425_RS05860	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1425_RS05865	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1425_RS05870	COG0300	oxidoreductase activity
M1425_RS05875	COG0243	molybdopterin cofactor binding
M1425_RS05900	COG0650	Formate hydrogenlyase subunit 4
M1425_RS05910	COG0651	ATP synthesis coupled electron transport
M1425_RS05915	COG0649	NAD binding
M1425_RS05920	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1425_RS05925	COG0651	ATP synthesis coupled electron transport
M1425_RS05935	COG2897	thiosulfate sulfurtransferase activity
M1425_RS05940	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M1425_RS05955	COG0028	Belongs to the TPP enzyme family
M1425_RS05960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1425_RS06005	COG0395	ABC-type sugar transport system, permease component
M1425_RS06035	COG0157	Belongs to the NadC ModD family
M1425_RS06065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M1425_RS06075	COG0297	glycogen (starch) synthase activity
M1425_RS06085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1425_RS06120	COG0469	pyruvate kinase activity
M1425_RS06135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1425_RS06145	COG0528	UMP kinase activity
M1425_RS06155	COG1028	Short-chain dehydrogenase reductase Sdr
M1425_RS06170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1425_RS06175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M1425_RS06185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M1425_RS06215	COG1110	DNA topoisomerase II activity
M1425_RS06255	COG0154	amidase activity
M1425_RS06270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M1425_RS06270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M1425_RS06325	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
M1425_RS06355	COG0252	asparaginase activity
M1425_RS06360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1425_RS06390	COG0719	Fe-S assembly protein
M1425_RS06390	COG1372	Participates in initiation and elongation during chromosome replication
M1425_RS06395	COG0719	Fe-S assembly protein
M1425_RS06400	COG0396	ATPase activity
M1425_RS06420	COG0509	glycine decarboxylation via glycine cleavage system
M1425_RS06425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M1425_RS06435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M1425_RS06455	COG0148	phosphopyruvate hydratase activity
M1425_RS06475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1425_RS06480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1425_RS06495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M1425_RS06525	COG0644	oxidoreductase
M1425_RS06530	COG0525	valine-tRNA ligase activity
M1425_RS06535	COG0436	Aminotransferase
M1425_RS06540	COG0134	indole-3-glycerol-phosphate synthase activity
M1425_RS06545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1425_RS06545	COG0512	Glutamine amidotransferase of anthranilate synthase
M1425_RS06550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1425_RS06555	COG0135	phosphoribosylanthranilate isomerase activity
M1425_RS06565	COG0159	tryptophan synthase activity
M1425_RS06570	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
M1425_RS06575	COG1254	Belongs to the acylphosphatase family
M1425_RS06580	COG1260	myo-inositol-1-phosphate synthase
M1425_RS06585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1425_RS06585	COG0574	Belongs to the PEP-utilizing enzyme family
M1425_RS06605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1425_RS06610	COG0460	homoserine dehydrogenase
M1425_RS06610	COG0527	aspartate kinase activity
M1425_RS06630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M1425_RS06665	COG0459	protein refolding
M1425_RS06715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M1425_RS06775	COG0315	cyclic pyranopterin monophosphate synthase activity
M1425_RS06780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1425_RS06785	COG2255	four-way junction helicase activity
M1425_RS06790	COG1881	PFAM PEBP family protein
M1425_RS06795	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M1425_RS06805	COG1063	alcohol dehydrogenase
M1425_RS06830	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M1425_RS06840	COG1047	Peptidyl-prolyl cis-trans
M1425_RS06860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M1425_RS06875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1425_RS06910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1425_RS06915	COG2264	protein methyltransferase activity
M1425_RS06920	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
M1425_RS06930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M1425_RS06975	COG1185	polyribonucleotide nucleotidyltransferase activity
M1425_RS07000	COG0322	excinuclease ABC activity
M1425_RS07005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M1425_RS07025	COG0473	3-isopropylmalate dehydrogenase activity
M1425_RS07030	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1425_RS07040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M1425_RS07055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M1425_RS07060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M1425_RS07065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M1425_RS07070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M1425_RS07075	COG0255	Belongs to the universal ribosomal protein uL29 family
M1425_RS07085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M1425_RS07090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M1425_RS07095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M1425_RS07105	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M1425_RS07115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M1425_RS07120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M1425_RS07140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M1425_RS07175	COG0563	adenylate kinase activity
M1425_RS07225	COG1136	(ABC) transporter
M1425_RS07225	COG0577	efflux transmembrane transporter activity
M1425_RS07235	COG0069	glutamate synthase activity
M1425_RS07240	COG0067	glutamate synthase
M1425_RS07255	COG0402	S-adenosylhomocysteine deaminase activity
M1425_RS07270	COG0303	'Molybdopterin
M1425_RS07285	COG2226	methyltransferase
M1425_RS07305	COG1321	iron dependent repressor
M1425_RS07315	COG2379	hydroxypyruvate reductase
M1425_RS07320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1425_RS07325	COG0009	L-threonylcarbamoyladenylate synthase
M1425_RS07335	COG0312	modulator of DNA gyrase
M1425_RS07340	COG0312	modulator of DNA gyrase
M1425_RS07345	COG0864	Transcriptional regulator
M1425_RS07355	COG0460	homoserine dehydrogenase
M1425_RS07370	COG1024	Enoyl-CoA hydratase
M1425_RS07410	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1425_RS07420	COG0189	ligase activity
M1425_RS07430	COG0505	Belongs to the CarA family
M1425_RS07435	COG0165	Argininosuccinate lyase
M1425_RS07440	COG0137	argininosuccinate synthase activity
M1425_RS07455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M1425_RS07460	COG0151	Belongs to the GarS family
M1425_RS07465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M1425_RS07470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M1425_RS07480	COG0047	phosphoribosylformylglycinamidine synthase activity
M1425_RS07490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M1425_RS07495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1425_RS07495	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1425_RS07500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M1425_RS07505	COG0602	queuosine metabolic process
M1425_RS07540	COG0284	orotidine-5'-phosphate decarboxylase activity
M1425_RS07545	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M1425_RS07550	COG0540	Belongs to the ATCase OTCase family
M1425_RS07555	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
M1425_RS07570	COG0167	dihydroorotate dehydrogenase activity
M1425_RS07585	COG2095	MarC family integral membrane protein
M1425_RS07590	COG1522	sequence-specific DNA binding
M1425_RS07605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1425_RS07610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M1425_RS07615	COG2151	metal-sulfur cluster biosynthetic enzyme
M1425_RS07625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1425_RS07630	COG0140	phosphoribosyl-ATP diphosphatase activity
M1425_RS07630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1425_RS07635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1425_RS07640	COG0107	imidazoleglycerol-phosphate synthase activity
M1425_RS07645	COG0131	Imidazoleglycerol-phosphate dehydratase
M1425_RS07650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M1425_RS07655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1425_RS07660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M1425_RS07670	COG0495	leucyl-tRNA aminoacylation
M1425_RS07675	COG2096	Adenosyltransferase
M1425_RS07680	COG0037	tRNA processing
M1425_RS07690	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M1425_RS07715	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M1425_RS07725	COG0028	Belongs to the TPP enzyme family
M1425_RS07735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M1425_RS07750	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M1425_RS07755	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M1425_RS07765	COG0442	prolyl-tRNA aminoacylation
M1425_RS07780	COG1394	ATPase activity, coupled to movement of substances
M1425_RS07790	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
M1425_RS07810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1425_RS07840	COG0417	DNA replication proofreading
M1425_RS07855	COG0668	transmembrane transport
M1425_RS07865	COG0126	phosphoglycerate kinase activity
M1425_RS07875	COG0589	response to stress
M1425_RS07880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M1425_RS07900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1425_RS07905	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M1425_RS07995	COG0495	leucyl-tRNA aminoacylation
M1425_RS08045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1425_RS08060	COG0581	inorganic phosphate transmembrane transporter activity
M1425_RS08075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1425_RS08080	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M1425_RS08095	COG0805	protein transport
M1425_RS08105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M1425_RS08130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1425_RS08140	COG0556	nucleotide-excision repair
M1425_RS08145	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1425_RS08155	COG3276	selenocysteine insertion sequence binding
M1425_RS08175	COG1992	Thiamine-phosphate synthase
M1425_RS08175	COG0351	phosphomethylpyrimidine kinase
M1425_RS08205	COG0489	protein tyrosine kinase activity
M1425_RS08225	COG1280	lysine exporter protein (LysE YggA)
M1425_RS08255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1425_RS08300	COG0010	Belongs to the arginase family
M1425_RS08305	COG0423	glycine-tRNA ligase activity
M1425_RS08335	COG0163	prenyltransferase activity
M1425_RS08340	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
M1425_RS08365	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M1425_RS08370	COG0667	Aldo Keto reductase
M1425_RS08415	COG1110	DNA topoisomerase II activity
M1425_RS08420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1425_RS08425	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
M1425_RS08440	COG0539	negative regulation of cytoplasmic translation
M1425_RS08470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M1425_RS08485	COG1797	cobyrinic acid a,c-diamide synthase activity
M1425_RS08505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M1425_RS08515	COG0402	S-adenosylhomocysteine deaminase activity
M1425_RS08535	COG1201	RNA secondary structure unwinding
M1425_RS08550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1425_RS08555	COG2813	Specifically methylates the guanine in position
M1425_RS08565	COG1444	tRNA N-acetyltransferase activity
M1425_RS08610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M1425_RS08615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1425_RS08625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1425_RS08650	COG0475	glutathione-regulated potassium exporter activity
M1425_RS08660	COG0535	radical SAM domain protein
M1425_RS08665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1425_RS08670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M1425_RS08670	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M1425_RS08680	COG0318	PFAM AMP-dependent synthetase and ligase
M1425_RS08685	COG3118	belongs to the thioredoxin family
M1425_RS08690	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1425_RS08705	COG0302	gtp cyclohydrolase
M1425_RS08715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1425_RS08730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1425_RS08795	COG0552	protein localization to endoplasmic reticulum
M1425_RS08810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M1425_RS08820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M1425_RS08830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1425_RS08855	COG0301	tRNA thio-modification
M1425_RS08860	COG1260	myo-inositol-1-phosphate synthase
M1425_RS08865	COG1007	ATP synthesis coupled electron transport
M1425_RS08870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1425_RS08875	COG0713	ATP synthesis coupled electron transport
M1425_RS08885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1425_RS08890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M1425_RS08895	COG0649	NAD binding
M1425_RS08900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1425_RS08910	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M1425_RS08930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1425_RS08935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1425_RS08975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1425_RS08985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M1425_RS08990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M1425_RS08995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M1425_RS09000	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M1425_RS09005	COG1605	Chorismate mutase
M1425_RS09005	COG0077	Prephenate dehydratase
M1425_RS09010	COG3958	Transketolase
M1425_RS09015	COG3959	Transketolase, thiamine diphosphate binding domain
M1425_RS09020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M1425_RS09040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M1425_RS09050	COG1185	polyribonucleotide nucleotidyltransferase activity
M1425_RS09075	COG0477	Major facilitator Superfamily
M1425_RS09215	COG1121	(ABC) transporter
M1425_RS09220	COG1980	fructose-bisphosphate aldolase activity
M1425_RS09245	COG0459	protein refolding
M1425_RS09260	COG0124	histidyl-tRNA synthetase
M1425_RS09295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1425_RS09305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1425_RS09380	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M1425_RS09415	COG1056	cytidyltransferase-related domain
M1425_RS09415	COG1051	belongs to the nudix hydrolase family
M1425_RS09430	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M1425_RS09430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M1425_RS09455	COG1605	Chorismate mutase
M1425_RS09455	COG0077	Prephenate dehydratase
M1425_RS09470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1425_RS09485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1425_RS09500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1425_RS09515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1425_RS09520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M1425_RS09535	COG0105	UTP biosynthetic process
M1425_RS09550	COG0085	RNA polymerase activity
M1425_RS09555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M1425_RS09560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M1425_RS09585	COG0049	tRNA binding
M1425_RS09590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M1425_RS09595	COG0051	transcription antitermination factor activity, RNA binding
M1425_RS09635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M1425_RS09640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1425_RS09650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1425_RS09670	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M1425_RS09675	COG0504	CTP synthase activity
M1425_RS09690	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
M1425_RS09720	COG2078	PFAM AMMECR1 domain protein
M1425_RS09735	COG0717	Belongs to the dCTP deaminase family
M1425_RS09740	COG1793	dna ligase
M1425_RS09745	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M1425_RS09745	COG1793	dna ligase
M1425_RS09750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1425_RS09775	COG0181	hydroxymethylbilane synthase activity
M1425_RS09780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M1425_RS09785	COG0113	porphobilinogen synthase activity
M1425_RS09790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M1425_RS09810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1425_RS09830	COG0585	pseudouridine synthase activity
M1425_RS09835	COG0017	Asparaginyl-tRNA synthetase
M1425_RS09850	COG0028	Belongs to the TPP enzyme family
M1425_RS09865	COG1122	ATPase activity
M1425_RS09895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1425_RS09900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1425_RS09905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1425_RS09910	COG0189	ligase activity
M1425_RS09925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M1425_RS09930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M1425_RS09945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1425_RS09990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M1425_RS10025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1425_RS10030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1425_RS10080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1425_RS10095	COG1201	RNA secondary structure unwinding
M1425_RS10100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M1425_RS10100	COG0617	tRNA 3'-terminal CCA addition
M1425_RS10100	COG0517	IMP dehydrogenase activity
M1425_RS10125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1425_RS10130	COG1058	Belongs to the CinA family
M1425_RS10130	COG1546	Belongs to the CinA family
M1425_RS10135	COG2267	carboxylic ester hydrolase activity
M1425_RS10150	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M1425_RS10175	COG1078	dGTPase activity
M1425_RS10180	COG0561	phosphatase activity
M1425_RS10185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1425_RS10200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M1425_RS10230	COG0456	acetyltransferase
M1425_RS10230	COG1214	PFAM Peptidase M22, glycoprotease
M1425_RS10245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1425_RS10260	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M1425_RS10265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M1425_RS10270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M1425_RS10280	COG0200	Binds to the 23S rRNA
M1425_RS10285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M1425_RS10290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1425_RS10300	COG0052	Belongs to the universal ribosomal protein uS2 family
M1425_RS10305	COG1355	regulation of microtubule-based process
M1425_RS10320	COG1304	FMN binding
M1425_RS10375	COG1131	(ABC) transporter
M1425_RS10405	COG0084	hydrolase, TatD family'
M1425_RS10420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1425_RS10460	COG1192	Involved in chromosome partitioning
M1425_RS10480	COG3620	sequence-specific DNA binding
M1425_RS10480	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M1425_RS10480	COG0617	tRNA 3'-terminal CCA addition
M1425_RS10490	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M1425_RS10535	COG1201	RNA secondary structure unwinding
M1425_RS10545	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1425_RS10570	COG2860	membrane
M1425_RS10585	COG0123	including yeast histone deacetylase and acetoin utilization protein
M1425_RS10605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1425_RS10610	COG0352	thiamine-phosphate diphosphorylase activity
M1425_RS10610	COG0351	phosphomethylpyrimidine kinase
M1425_RS10620	COG1215	transferase activity, transferring glycosyl groups
M1425_RS10675	COG0463	Glycosyl transferase, family 2
M1425_RS10695	COG1063	alcohol dehydrogenase
M1425_RS10715	COG0519	Catalyzes the synthesis of GMP from XMP
M1425_RS10715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1425_RS10720	COG0501	Belongs to the peptidase M48B family
M1425_RS10725	COG0517	IMP dehydrogenase activity
M1425_RS10725	COG0516	GMP reductase activity
M1425_RS10735	COG1830	Aldolase
M1425_RS10760	COG0405	Gamma-glutamyltransferase
M1425_RS10775	COG1444	tRNA N-acetyltransferase activity
M1425_RS10790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1425_RS10800	COG0656	L-ascorbic acid biosynthetic process
M1425_RS10815	COG0251	oxidation-reduction process
M1425_RS10820	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M1425_RS10820	COG0617	tRNA 3'-terminal CCA addition
M1425_RS10820	COG0517	IMP dehydrogenase activity
M1425_RS10825	COG1063	alcohol dehydrogenase
M1425_RS10830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1425_RS10840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M1425_RS10850	COG4948	Mandelate Racemase Muconate Lactonizing
M1425_RS10855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1425_RS10860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1425_RS10865	COG1012	belongs to the aldehyde dehydrogenase family
M1425_RS10875	COG0243	molybdopterin cofactor binding
M1425_RS10915	COG0833	amino acid
M1425_RS10920	COG0589	response to stress
M1425_RS10935	COG2814	Major facilitator Superfamily
M1425_RS11010	COG1733	regulation of RNA biosynthetic process
M1425_RS11020	COG0516	GMP reductase activity
M1425_RS11020	COG0517	IMP dehydrogenase activity
M1425_RS11025	COG1720	tRNA m6t6A37 methyltransferase activity
M1425_RS11065	COG0277	FAD linked oxidase domain protein
M1425_RS11070	COG0247	lactate metabolic process
M1425_RS11075	COG0095	Lipoate-protein ligase
M1425_RS11080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1425_RS11095	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1425_RS11130	COG1960	acyl-CoA dehydrogenase activity
M1425_RS11140	COG2271	Major facilitator Superfamily
M1425_RS11170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M1425_RS11190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1425_RS11200	COG1139	Iron-sulfur cluster binding protein
M1425_RS11205	COG2814	Major facilitator Superfamily
M1425_RS11220	COG4948	Mandelate Racemase Muconate Lactonizing
M1425_RS11230	COG0477	Major facilitator Superfamily
M1425_RS11235	COG2271	Major facilitator Superfamily
M1425_RS11240	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1425_RS11250	COG2267	carboxylic ester hydrolase activity
M1425_RS11260	COG1028	Short-chain dehydrogenase reductase Sdr
M1425_RS11290	COG0805	protein transport
M1425_RS11305	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M1425_RS11345	COG1122	ATPase activity
M1425_RS11385	COG0425	Belongs to the sulfur carrier protein TusA family
M1425_RS11390	COG2391	methyltransferase activity
M1425_RS11405	COG1131	(ABC) transporter
M1425_RS11470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1425_RS11480	COG3842	ATPase activity
M1425_RS11485	COG0395	ABC-type sugar transport system, permease component
M1425_RS11500	COG0318	PFAM AMP-dependent synthetase and ligase
M1425_RS11535	COG0667	Aldo Keto reductase
M1425_RS11560	COG0673	inositol 2-dehydrogenase activity
M1425_RS11570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1425_RS11575	COG0444	Belongs to the ABC transporter superfamily
M1425_RS11580	COG4608	Belongs to the ABC transporter superfamily
M1425_RS11595	COG3386	PFAM SMP-30 Gluconolaconase
M1425_RS11610	COG3250	beta-galactosidase activity
M1425_RS11625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1425_RS11630	COG1472	Belongs to the glycosyl hydrolase 3 family
M1425_RS11685	COG4948	Mandelate Racemase Muconate Lactonizing
M1425_RS11690	COG3408	Glycogen debranching enzyme
M1425_RS11715	COG1501	Belongs to the glycosyl hydrolase 31 family
M1425_RS11725	COG2723	6-phospho-beta-galactosidase activity
M1425_RS11745	COG0667	Aldo Keto reductase
M1425_RS11760	COG1132	(ABC) transporter
M1425_RS11780	COG0673	inositol 2-dehydrogenase activity
M1425_RS11795	COG1028	Short-chain dehydrogenase reductase Sdr
M1425_RS11810	COG0459	protein refolding
M1425_RS11815	COG4948	Mandelate Racemase Muconate Lactonizing
M1425_RS11820	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1425_RS11825	COG1914	H( )-stimulated, divalent metal cation uptake system
M1425_RS11900	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M1425_RS11920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1425_RS11935	COG2857	Cytochrome c1
M1425_RS11935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M1425_RS11985	COG0601	transmembrane transport
M1425_RS11990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1425_RS11995	COG0444	Belongs to the ABC transporter superfamily
M1425_RS12000	COG4608	Belongs to the ABC transporter superfamily
M1425_RS12080	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
M1425_RS12115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1425_RS12120	COG1648	precorrin-2 dehydrogenase activity
M1425_RS12120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1425_RS12125	COG2897	thiosulfate sulfurtransferase activity
M1425_RS12160	COG0667	Aldo Keto reductase
M1425_RS12175	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M1425_RS12175	COG3608	succinylglutamate desuccinylase aspartoacylase
M1425_RS12185	COG1960	acyl-CoA dehydrogenase activity
M1425_RS12190	COG0318	PFAM AMP-dependent synthetase and ligase
M1425_RS12205	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1425_RS12215	COG0281	malic enzyme
M1425_RS12240	COG1584	GPR1 FUN34 yaaH family protein
M1425_RS12245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1425_RS12280	COG0477	Major facilitator Superfamily
M1425_RS12285	COG3842	ATPase activity
M1425_RS12290	COG0395	ABC-type sugar transport system, permease component
M1425_RS12345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1425_RS12385	COG3383	formate dehydrogenase (NAD+) activity
M1425_RS12395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1425_RS12400	COG0574	Belongs to the PEP-utilizing enzyme family
M1425_RS12400	COG3848	Pyruvate phosphate dikinase
M1425_RS12410	COG0644	oxidoreductase
M1425_RS12415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M1425_RS12420	COG1013	pyruvate-flavodoxin oxidoreductase activity
M1425_RS12425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M1425_RS12425	COG0674	pyruvate-flavodoxin oxidoreductase activity
M1425_RS12450	COG0318	PFAM AMP-dependent synthetase and ligase
M1425_RS12505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M1425_RS12530	COG1063	alcohol dehydrogenase
M1425_RS12555	COG0243	molybdopterin cofactor binding
M1425_RS12560	COG0437	4 iron, 4 sulfur cluster binding
M1425_RS12685	COG0668	transmembrane transport
M1425_RS12690	COG0586	Pfam SNARE associated Golgi protein
M1425_RS12705	COG0022	dehydrogenase e1 component
M1425_RS12735	COG0656	L-ascorbic acid biosynthetic process
M1425_RS12740	COG0589	response to stress
M1425_RS12750	COG0644	oxidoreductase
M1425_RS12765	COG0028	Belongs to the TPP enzyme family
M1425_RS12780	COG0402	S-adenosylhomocysteine deaminase activity
M1425_RS12800	COG0492	ferredoxin-NADP+ reductase activity
M1425_RS12810	COG2086	electron transfer activity
M1425_RS12820	COG1960	acyl-CoA dehydrogenase activity
M1425_RS12835	COG0437	4 iron, 4 sulfur cluster binding
M1425_RS12840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M1425_RS12845	COG1144	Oxidoreductase
M1425_RS12850	COG0674	pyruvate-flavodoxin oxidoreductase activity
M1425_RS12855	COG1013	pyruvate-flavodoxin oxidoreductase activity
M1425_RS12860	COG0438	transferase activity, transferring glycosyl groups
M1425_RS12865	COG3387	PFAM Glycoside hydrolase 15-related
M1425_RS12920	COG3387	PFAM Glycoside hydrolase 15-related
M1425_RS12930	COG0517	IMP dehydrogenase activity
M1425_RS12940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1425_RS13000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1425_RS13010	COG2814	Major facilitator Superfamily
M1425_RS13025	COG0395	ABC-type sugar transport system, permease component
M1425_RS13030	COG3842	ATPase activity
M1425_RS13060	COG0813	purine-nucleoside phosphorylase activity
M1425_RS13065	COG3386	PFAM SMP-30 Gluconolaconase
M1425_RS13070	COG2814	Major facilitator Superfamily
M1425_RS13115	COG4274	PFAM GYD family protein
M1425_RS13125	COG4946	Tricorn protease homolog
M1425_RS13125	COG0823	Involved in the tonB-independent uptake of proteins
M1425_RS13125	COG1506	peptidase
M1425_RS13140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1425_RS13225	COG4608	Belongs to the ABC transporter superfamily
M1425_RS13230	COG0444	Belongs to the ABC transporter superfamily
M1425_RS13245	COG0601	transmembrane transport
M1425_RS13260	COG4948	Mandelate Racemase Muconate Lactonizing
M1425_RS13265	COG1028	Short-chain dehydrogenase reductase Sdr
M1425_RS13320	COG2217	Heavy metal translocating P-type atpase
M1425_RS13330	COG4555	ABC transporter
M1425_RS13355	COG1592	Rubrerythrin
M1425_RS13390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1425_RS13440	COG0183	Belongs to the thiolase family
M1425_RS13450	COG1024	Enoyl-CoA hydratase
M1425_RS13475	COG0601	transmembrane transport
M1425_RS13480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1425_RS13485	COG0444	Belongs to the ABC transporter superfamily
M1425_RS13490	COG4608	Belongs to the ABC transporter superfamily
M1425_RS13500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1425_RS13505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1425_RS13520	COG0438	transferase activity, transferring glycosyl groups
M1425_RS13540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1425_RS13565	COG1131	(ABC) transporter
M1425_RS13570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1425_RS13580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1425_RS13600	COG0149	triose-phosphate isomerase activity
M1425_RS13615	COG0372	Belongs to the citrate synthase family
M1425_RS13620	COG0517	IMP dehydrogenase activity
M1425_RS13620	COG0516	GMP reductase activity
M1425_RS13625	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M1425_RS13630	COG2079	MmgE PrpD family protein
M1425_RS13635	COG0039	L-malate dehydrogenase activity
M1425_RS13640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1425_RS13690	COG1489	DNA binding
M1425_RS13720	COG0778	Nitroreductase
M1425_RS13725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1425_RS13855	COG0308	aminopeptidase N
M1425_RS13870	COG0561	phosphatase activity
M1425_RS13880	COG1011	Hydrolase
M1425_RS13895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M1425_RS13925	COG0494	nUDIX hydrolase
M1425_RS13935	COG3253	May function as heme-dependent peroxidase
M1425_RS13950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1425_RS13980	COG2226	methyltransferase
M1425_RS14005	COG0538	isocitrate dehydrogenase activity
M1425_RS14180	COG1305	Transglutaminase-like
M1425_RS14365	COG1215	transferase activity, transferring glycosyl groups
M1425_RS14455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M1425_RS14635	COG1131	(ABC) transporter