locus-tag	class	description
M1627_RS00020	COG2154	pterin-4-alpha-carbinolamine dehydratase
M1627_RS00100	COG1331	Highly conserved protein containing a thioredoxin domain
M1627_RS00110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1627_RS00120	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
M1627_RS00145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1627_RS00160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1627_RS00170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1627_RS00175	COG2814	Major facilitator Superfamily
M1627_RS00185	COG0492	ferredoxin-NADP+ reductase activity
M1627_RS00255	COG0588	phosphoglycerate mutase activity
M1627_RS00275	COG1957	nucleoside hydrolase
M1627_RS00325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1627_RS00325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1627_RS00330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1627_RS00335	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
M1627_RS00355	COG0596	Alpha beta hydrolase
M1627_RS00365	COG1703	isobutyryl-CoA mutase activity
M1627_RS00370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M1627_RS00410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1627_RS00415	COG1573	uracil-dna glycosylase
M1627_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
M1627_RS00445	COG0215	cysteine-tRNA ligase activity
M1627_RS00450	COG2222	sugar isomerase
M1627_RS00460	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1627_RS00470	COG0433	COG0433 Predicted ATPase
M1627_RS00480	COG1607	acyl-coa hydrolase
M1627_RS00490	COG1028	Short-chain dehydrogenase reductase Sdr
M1627_RS00495	COG0708	Exodeoxyribonuclease III
M1627_RS00500	COG0515	serine threonine protein kinase
M1627_RS00500	COG2815	serine threonine protein kinase
M1627_RS00535	COG1648	precorrin-2 dehydrogenase activity
M1627_RS00535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1627_RS00545	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
M1627_RS00570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1627_RS00580	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
M1627_RS00660	COG1063	alcohol dehydrogenase
M1627_RS00690	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M1627_RS00695	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M1627_RS00710	COG0189	ligase activity
M1627_RS00750	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M1627_RS00770	COG1053	succinate dehydrogenase
M1627_RS00790	COG2304	oxidoreductase activity
M1627_RS00795	COG0714	Associated with various cellular activities
M1627_RS00815	COG0083	homoserine kinase activity
M1627_RS00820	COG0626	cystathionine gamma-synthase activity
M1627_RS00860	COG0183	Belongs to the thiolase family
M1627_RS00865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1627_RS00905	COG1215	transferase activity, transferring glycosyl groups
M1627_RS00910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1627_RS00920	COG0351	phosphomethylpyrimidine kinase
M1627_RS00925	COG0314	molybdopterin synthase activity
M1627_RS00950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M1627_RS00960	COG1131	(ABC) transporter
M1627_RS00990	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M1627_RS00995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1627_RS01025	COG0720	synthase
M1627_RS01040	COG0492	ferredoxin-NADP+ reductase activity
M1627_RS01050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1627_RS01070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M1627_RS01070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M1627_RS01080	COG0071	Belongs to the small heat shock protein (HSP20) family
M1627_RS01140	COG0402	S-adenosylhomocysteine deaminase activity
M1627_RS01165	COG0430	RNA-3'-phosphate cyclase activity
M1627_RS01175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1627_RS01180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1627_RS01185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1627_RS01195	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M1627_RS01205	COG1515	deoxyribonuclease V activity
M1627_RS01210	COG1335	isochorismatase
M1627_RS01245	COG4581	dead DEAH box helicase
M1627_RS01250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1627_RS01260	COG0439	Biotin carboxylase
M1627_RS01270	COG1116	anion transmembrane transporter activity
M1627_RS01280	COG0066	3-isopropylmalate dehydratase activity
M1627_RS01285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M1627_RS01290	COG0415	Belongs to the DNA photolyase family
M1627_RS01325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1627_RS01340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1627_RS01345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1627_RS01360	COG0045	succinate-CoA ligase (ADP-forming) activity
M1627_RS01410	COG0657	acetylesterase activity
M1627_RS01415	COG1063	alcohol dehydrogenase
M1627_RS01420	COG0183	Belongs to the thiolase family
M1627_RS01425	COG1960	acyl-CoA dehydrogenase activity
M1627_RS01430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1627_RS01435	COG1028	Short-chain dehydrogenase reductase Sdr
M1627_RS01440	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1627_RS01485	COG0318	PFAM AMP-dependent synthetase and ligase
M1627_RS01490	COG1960	acyl-CoA dehydrogenase activity
M1627_RS01495	COG1024	Enoyl-CoA hydratase
M1627_RS01500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1627_RS01505	COG2814	Major facilitator Superfamily
M1627_RS01505	COG0477	Major facilitator Superfamily
M1627_RS01535	COG0657	acetylesterase activity
M1627_RS01545	COG0318	PFAM AMP-dependent synthetase and ligase
M1627_RS01555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M1627_RS01560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1627_RS01575	COG2814	Major facilitator Superfamily
M1627_RS01575	COG0477	Major facilitator Superfamily
M1627_RS01685	COG0432	Pfam Uncharacterised protein family UPF0047
M1627_RS01690	COG1305	Transglutaminase-like
M1627_RS01710	COG1522	sequence-specific DNA binding
M1627_RS01715	COG1013	pyruvate-flavodoxin oxidoreductase activity
M1627_RS01720	COG0674	pyruvate-flavodoxin oxidoreductase activity
M1627_RS01735	COG1620	l-lactate permease
M1627_RS01740	COG1487	ribonuclease activity
M1627_RS01750	COG2226	methyltransferase
M1627_RS01765	COG0450	alkyl hydroperoxide reductase
M1627_RS01845	COG1335	isochorismatase
M1627_RS01885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M1627_RS01890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M1627_RS01900	COG2062	phosphohistidine phosphatase, SixA
M1627_RS01915	COG0674	pyruvate-flavodoxin oxidoreductase activity
M1627_RS01960	COG0277	FAD linked oxidase domain protein
M1627_RS02045	COG1741	Belongs to the pirin family
M1627_RS02060	COG1024	Enoyl-CoA hydratase
M1627_RS02070	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
M1627_RS02100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M1627_RS02100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1627_RS02110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M1627_RS02145	COG1017	nitric oxide dioxygenase activity
M1627_RS02180	COG4608	Belongs to the ABC transporter superfamily
M1627_RS02185	COG0444	Belongs to the ABC transporter superfamily
M1627_RS02195	COG0601	transmembrane transport
M1627_RS02210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1627_RS02225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1627_RS02230	COG1131	(ABC) transporter
M1627_RS02255	COG2721	sulfolactate sulfo-lyase activity
M1627_RS02260	COG2721	sulfolactate sulfo-lyase activity
M1627_RS02275	COG1802	Transcriptional regulator
M1627_RS02280	COG2301	Belongs to the HpcH HpaI aldolase family
M1627_RS02285	COG2050	protein possibly involved in aromatic compounds catabolism
M1627_RS02285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M1627_RS02295	COG0598	Magnesium transport protein CorA
M1627_RS02330	COG2084	Dehydrogenase
M1627_RS02435	COG0412	Dienelactone hydrolase
M1627_RS02480	COG0793	Belongs to the peptidase S41A family
M1627_RS02480	COG4946	Tricorn protease homolog
M1627_RS02485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1627_RS02540	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M1627_RS02565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M1627_RS02590	COG1960	acyl-CoA dehydrogenase activity
M1627_RS02595	COG0318	PFAM AMP-dependent synthetase and ligase
M1627_RS02610	COG2814	Major facilitator Superfamily
M1627_RS02630	COG1725	Transcriptional regulator
M1627_RS02665	COG0243	molybdopterin cofactor binding
M1627_RS02695	COG0393	Putative heavy-metal-binding
M1627_RS02755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1627_RS02840	COG1953	Uracil, thiamine, allantoin
M1627_RS02880	COG2814	Major facilitator Superfamily
M1627_RS02885	COG4948	Mandelate Racemase Muconate Lactonizing
M1627_RS02925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1627_RS02930	COG0477	Major facilitator Superfamily
M1627_RS02940	COG1028	Short-chain dehydrogenase reductase Sdr
M1627_RS03010	COG1401	restriction endodeoxyribonuclease activity
M1627_RS03030	COG1091	dTDP-4-dehydrorhamnose reductase activity
M1627_RS03060	COG0438	transferase activity, transferring glycosyl groups
M1627_RS03090	COG1215	transferase activity, transferring glycosyl groups
M1627_RS03095	COG0438	transferase activity, transferring glycosyl groups
M1627_RS03100	COG0438	transferase activity, transferring glycosyl groups
M1627_RS03110	COG0438	transferase activity, transferring glycosyl groups
M1627_RS03155	COG1216	Glycosyl transferase, family 2
M1627_RS03190	COG0463	Glycosyl transferase, family 2
M1627_RS03195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1627_RS03200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M1627_RS03220	COG0463	Glycosyl transferase, family 2
M1627_RS03270	COG2224	Isocitrate lyase
M1627_RS03275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1627_RS03285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1627_RS03290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1627_RS03300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M1627_RS03300	COG2146	nitrite reductase [NAD(P)H] activity
M1627_RS03325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1627_RS03330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1627_RS03335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1627_RS03380	COG1960	acyl-CoA dehydrogenase activity
M1627_RS03385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1627_RS03395	COG2271	Major facilitator Superfamily
M1627_RS03410	COG2368	4-hydroxyphenylacetate
M1627_RS03455	COG0477	Major facilitator Superfamily
M1627_RS03480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1627_RS03485	COG0531	amino acid
M1627_RS03490	COG1953	Uracil, thiamine, allantoin
M1627_RS03495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1627_RS03550	COG1011	Hydrolase
M1627_RS03605	COG0425	Belongs to the sulfur carrier protein TusA family
M1627_RS03640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M1627_RS03640	COG1042	CoA-binding domain protein
M1627_RS03640	COG0045	succinate-CoA ligase (ADP-forming) activity
M1627_RS03660	COG2226	methyltransferase
M1627_RS03670	COG1136	(ABC) transporter
M1627_RS03670	COG0577	efflux transmembrane transporter activity
M1627_RS03680	COG0577	efflux transmembrane transporter activity
M1627_RS03750	COG2151	metal-sulfur cluster biosynthetic enzyme
M1627_RS03755	COG0589	response to stress
M1627_RS03770	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M1627_RS03790	COG0501	Belongs to the peptidase M48B family
M1627_RS03900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1627_RS03950	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M1627_RS03975	COG1073	alpha beta
M1627_RS04015	COG4689	acetoacetate decarboxylase
M1627_RS04020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1627_RS04030	COG2271	Major facilitator Superfamily
M1627_RS04035	COG4948	Mandelate Racemase Muconate Lactonizing
M1627_RS04040	COG0318	PFAM AMP-dependent synthetase and ligase
M1627_RS04045	COG2030	dehydratase
M1627_RS04070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1627_RS04080	COG1960	acyl-CoA dehydrogenase activity
M1627_RS04085	COG0095	Lipoate-protein ligase
M1627_RS04095	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1627_RS04100	COG0318	PFAM AMP-dependent synthetase and ligase
M1627_RS04120	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M1627_RS04125	COG1140	nitrate reductase beta subunit
M1627_RS04130	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M1627_RS04135	COG2181	nitrate reductase activity
M1627_RS04160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1627_RS04170	COG1454	alcohol dehydrogenase
M1627_RS04220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1627_RS04225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1627_RS04230	COG0022	dehydrogenase e1 component
M1627_RS04235	COG3199	ATP-NAD kinase
M1627_RS04240	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1627_RS04270	COG4948	Mandelate Racemase Muconate Lactonizing
M1627_RS04280	COG2814	Major facilitator Superfamily
M1627_RS04295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1627_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
M1627_RS04310	COG1172	Belongs to the binding-protein-dependent transport system permease family
M1627_RS04315	COG1129	ABC transporter
M1627_RS04350	COG0318	PFAM AMP-dependent synthetase and ligase
M1627_RS04355	COG1960	acyl-CoA dehydrogenase activity
M1627_RS04365	COG0183	Belongs to the thiolase family
M1627_RS04375	COG1960	acyl-CoA dehydrogenase activity
M1627_RS04395	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1627_RS04400	COG1024	Enoyl-CoA hydratase
M1627_RS04405	COG2814	Major facilitator Superfamily
M1627_RS04405	COG0477	Major facilitator Superfamily
M1627_RS04410	COG2814	Major facilitator Superfamily
M1627_RS04415	COG0277	FAD linked oxidase domain protein
M1627_RS04420	COG2271	Major facilitator Superfamily
M1627_RS04425	COG4948	Mandelate Racemase Muconate Lactonizing
M1627_RS04435	COG3976	FMN-binding domain protein
M1627_RS04435	COG1053	succinate dehydrogenase
M1627_RS04445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1627_RS04475	COG1024	Enoyl-CoA hydratase
M1627_RS04480	COG2271	Major facilitator Superfamily
M1627_RS04485	COG1012	belongs to the aldehyde dehydrogenase family
M1627_RS04485	COG2030	dehydratase
M1627_RS04490	COG1960	acyl-CoA dehydrogenase activity
M1627_RS04495	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M1627_RS04500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1627_RS04545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1627_RS04600	COG1203	CRISPR-associated helicase, Cas3
M1627_RS04785	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M1627_RS04820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1627_RS04920	COG1473	amidohydrolase
M1627_RS04945	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M1627_RS05010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1627_RS05030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M1627_RS05035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M1627_RS05050	COG1131	(ABC) transporter
M1627_RS05090	COG0675	Transposase, IS605 OrfB family
M1627_RS05295	COG2264	protein methyltransferase activity
M1627_RS05530	COG0535	radical SAM domain protein
M1627_RS05535	COG0535	radical SAM domain protein
M1627_RS05540	COG1012	belongs to the aldehyde dehydrogenase family
M1627_RS05580	COG2271	Major facilitator Superfamily
M1627_RS05625	COG1175	transmembrane transport
M1627_RS05630	COG3833	ABC-type maltose transport systems, permease component
M1627_RS05635	COG3842	ATPase activity
M1627_RS05645	COG2814	Major facilitator Superfamily
M1627_RS05675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M1627_RS05695	COG1960	acyl-CoA dehydrogenase activity
M1627_RS05730	COG0477	Major facilitator Superfamily
M1627_RS05735	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
M1627_RS05740	COG1131	(ABC) transporter
M1627_RS05765	COG0475	glutathione-regulated potassium exporter activity
M1627_RS05780	COG2048	Heterodisulfide reductase, subunit B
M1627_RS05810	COG0425	Belongs to the sulfur carrier protein TusA family
M1627_RS05815	COG2210	Belongs to the sulfur carrier protein TusA family
M1627_RS05860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M1627_RS05870	COG0095	Lipoate-protein ligase
M1627_RS05875	COG1832	CoA-binding protein
M1627_RS05905	COG0509	glycine decarboxylation via glycine cleavage system
M1627_RS05915	COG2271	Major facilitator Superfamily
M1627_RS05955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1627_RS06000	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1627_RS06010	COG1846	Transcriptional regulator
M1627_RS06015	COG0577	efflux transmembrane transporter activity
M1627_RS06015	COG1136	(ABC) transporter
M1627_RS06025	COG1136	(ABC) transporter
M1627_RS06030	COG0114	fumarate hydratase activity
M1627_RS06040	COG0517	IMP dehydrogenase activity
M1627_RS06045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1627_RS06045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1627_RS06050	COG0531	amino acid
M1627_RS06060	COG2005	Transcriptional regulator
M1627_RS06065	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1627_RS06070	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M1627_RS06090	COG0509	glycine decarboxylation via glycine cleavage system
M1627_RS06130	COG0004	ammonium transporteR
M1627_RS06150	COG1185	polyribonucleotide nucleotidyltransferase activity
M1627_RS06195	COG1234	tRNA 3'-trailer cleavage
M1627_RS06210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M1627_RS06245	COG0488	(ABC) transporter
M1627_RS06255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1627_RS06260	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1627_RS06265	COG0300	oxidoreductase activity
M1627_RS06270	COG3383	formate dehydrogenase (NAD+) activity
M1627_RS06285	COG0650	Formate hydrogenlyase subunit 4
M1627_RS06295	COG0651	ATP synthesis coupled electron transport
M1627_RS06300	COG0649	NAD binding
M1627_RS06305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1627_RS06310	COG0651	ATP synthesis coupled electron transport
M1627_RS06320	COG2897	thiosulfate sulfurtransferase activity
M1627_RS06325	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M1627_RS06340	COG0028	Belongs to the TPP enzyme family
M1627_RS06345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1627_RS06370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1627_RS06415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M1627_RS06425	COG0297	glycogen (starch) synthase activity
M1627_RS06435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1627_RS06445	COG0469	pyruvate kinase activity
M1627_RS06460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1627_RS06470	COG0528	UMP kinase activity
M1627_RS06480	COG1028	Short-chain dehydrogenase reductase Sdr
M1627_RS06495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1627_RS06500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M1627_RS06510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M1627_RS06540	COG1110	DNA topoisomerase II activity
M1627_RS06580	COG0154	amidase activity
M1627_RS06595	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M1627_RS06595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M1627_RS06650	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
M1627_RS06680	COG0252	asparaginase activity
M1627_RS06685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1627_RS06715	COG0719	Fe-S assembly protein
M1627_RS06715	COG1372	Participates in initiation and elongation during chromosome replication
M1627_RS06720	COG0719	Fe-S assembly protein
M1627_RS06725	COG0396	ATPase activity
M1627_RS06745	COG0509	glycine decarboxylation via glycine cleavage system
M1627_RS06750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M1627_RS06760	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M1627_RS06780	COG0148	phosphopyruvate hydratase activity
M1627_RS06800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1627_RS06805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1627_RS06820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M1627_RS06850	COG0644	oxidoreductase
M1627_RS06855	COG0525	valine-tRNA ligase activity
M1627_RS06860	COG0436	Aminotransferase
M1627_RS06865	COG0134	indole-3-glycerol-phosphate synthase activity
M1627_RS06870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1627_RS06870	COG0512	Glutamine amidotransferase of anthranilate synthase
M1627_RS06875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1627_RS06880	COG0135	phosphoribosylanthranilate isomerase activity
M1627_RS06890	COG0159	tryptophan synthase activity
M1627_RS06895	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
M1627_RS06900	COG1254	Belongs to the acylphosphatase family
M1627_RS06905	COG1260	myo-inositol-1-phosphate synthase
M1627_RS06910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1627_RS06910	COG0574	Belongs to the PEP-utilizing enzyme family
M1627_RS06930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1627_RS06935	COG0460	homoserine dehydrogenase
M1627_RS06935	COG0527	aspartate kinase activity
M1627_RS06955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M1627_RS06990	COG0459	protein refolding
M1627_RS07035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M1627_RS07095	COG0315	cyclic pyranopterin monophosphate synthase activity
M1627_RS07100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1627_RS07105	COG2255	four-way junction helicase activity
M1627_RS07110	COG1881	PFAM PEBP family protein
M1627_RS07115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M1627_RS07125	COG1063	alcohol dehydrogenase
M1627_RS07150	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M1627_RS07160	COG1047	Peptidyl-prolyl cis-trans
M1627_RS07175	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M1627_RS07190	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1627_RS07225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1627_RS07230	COG2264	protein methyltransferase activity
M1627_RS07235	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
M1627_RS07245	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M1627_RS07290	COG1185	polyribonucleotide nucleotidyltransferase activity
M1627_RS07315	COG0322	excinuclease ABC activity
M1627_RS07320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M1627_RS07340	COG0473	3-isopropylmalate dehydrogenase activity
M1627_RS07345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1627_RS07355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M1627_RS07370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M1627_RS07375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M1627_RS07380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M1627_RS07385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M1627_RS07390	COG0255	Belongs to the universal ribosomal protein uL29 family
M1627_RS07400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M1627_RS07405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M1627_RS07410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M1627_RS07420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M1627_RS07430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M1627_RS07435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M1627_RS07455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M1627_RS07490	COG0563	adenylate kinase activity
M1627_RS07605	COG0544	peptidyl-prolyl cis-trans isomerase activity
M1627_RS07815	COG1136	(ABC) transporter
M1627_RS07825	COG1136	(ABC) transporter
M1627_RS07825	COG0577	efflux transmembrane transporter activity
M1627_RS07835	COG0069	glutamate synthase activity
M1627_RS07840	COG0067	glutamate synthase
M1627_RS07855	COG0402	S-adenosylhomocysteine deaminase activity
M1627_RS07870	COG0303	'Molybdopterin
M1627_RS07885	COG2226	methyltransferase
M1627_RS07905	COG1321	iron dependent repressor
M1627_RS07915	COG2379	hydroxypyruvate reductase
M1627_RS07920	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1627_RS07925	COG0009	L-threonylcarbamoyladenylate synthase
M1627_RS07935	COG0312	modulator of DNA gyrase
M1627_RS07940	COG0312	modulator of DNA gyrase
M1627_RS07945	COG0864	Transcriptional regulator
M1627_RS07955	COG0460	homoserine dehydrogenase
M1627_RS07970	COG1024	Enoyl-CoA hydratase
M1627_RS08010	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1627_RS08020	COG0189	ligase activity
M1627_RS08030	COG0505	Belongs to the CarA family
M1627_RS08035	COG0165	Argininosuccinate lyase
M1627_RS08040	COG0137	argininosuccinate synthase activity
M1627_RS08055	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M1627_RS08060	COG0151	Belongs to the GarS family
M1627_RS08065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M1627_RS08070	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M1627_RS08080	COG0047	phosphoribosylformylglycinamidine synthase activity
M1627_RS08090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M1627_RS08095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1627_RS08095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1627_RS08100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M1627_RS08105	COG0602	queuosine metabolic process
M1627_RS08140	COG0284	orotidine-5'-phosphate decarboxylase activity
M1627_RS08145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M1627_RS08150	COG0540	Belongs to the ATCase OTCase family
M1627_RS08155	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
M1627_RS08170	COG0167	dihydroorotate dehydrogenase activity
M1627_RS08185	COG2095	MarC family integral membrane protein
M1627_RS08190	COG1522	sequence-specific DNA binding
M1627_RS08205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1627_RS08210	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M1627_RS08215	COG2151	metal-sulfur cluster biosynthetic enzyme
M1627_RS08225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1627_RS08230	COG0140	phosphoribosyl-ATP diphosphatase activity
M1627_RS08230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1627_RS08235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1627_RS08240	COG0107	imidazoleglycerol-phosphate synthase activity
M1627_RS08245	COG0131	Imidazoleglycerol-phosphate dehydratase
M1627_RS08250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M1627_RS08255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1627_RS08260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M1627_RS08270	COG0495	leucyl-tRNA aminoacylation
M1627_RS08275	COG2096	Adenosyltransferase
M1627_RS08280	COG0037	tRNA processing
M1627_RS08290	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M1627_RS08315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M1627_RS08325	COG0028	Belongs to the TPP enzyme family
M1627_RS08335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M1627_RS08350	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M1627_RS08355	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M1627_RS08365	COG0442	prolyl-tRNA aminoacylation
M1627_RS08380	COG1394	ATPase activity, coupled to movement of substances
M1627_RS08390	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
M1627_RS08410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1627_RS08440	COG0417	DNA replication proofreading
M1627_RS08455	COG0668	transmembrane transport
M1627_RS08465	COG0126	phosphoglycerate kinase activity
M1627_RS08475	COG0589	response to stress
M1627_RS08480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M1627_RS08500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M1627_RS08505	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M1627_RS08595	COG0495	leucyl-tRNA aminoacylation
M1627_RS08645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1627_RS08660	COG0581	inorganic phosphate transmembrane transporter activity
M1627_RS08675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1627_RS08680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M1627_RS08695	COG0805	protein transport
M1627_RS08705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M1627_RS08730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1627_RS08740	COG0556	nucleotide-excision repair
M1627_RS08745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1627_RS08755	COG3276	selenocysteine insertion sequence binding
M1627_RS08775	COG1992	Thiamine-phosphate synthase
M1627_RS08775	COG0351	phosphomethylpyrimidine kinase
M1627_RS08805	COG0489	protein tyrosine kinase activity
M1627_RS08825	COG1280	lysine exporter protein (LysE YggA)
M1627_RS08855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1627_RS08905	COG0423	glycine-tRNA ligase activity
M1627_RS08935	COG0163	prenyltransferase activity
M1627_RS08940	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
M1627_RS08960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M1627_RS08965	COG0667	Aldo Keto reductase
M1627_RS09010	COG1110	DNA topoisomerase II activity
M1627_RS09015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1627_RS09020	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
M1627_RS09035	COG0539	negative regulation of cytoplasmic translation
M1627_RS09065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M1627_RS09080	COG1797	cobyrinic acid a,c-diamide synthase activity
M1627_RS09100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M1627_RS09110	COG0402	S-adenosylhomocysteine deaminase activity
M1627_RS09130	COG1201	RNA secondary structure unwinding
M1627_RS09145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1627_RS09150	COG2813	Specifically methylates the guanine in position
M1627_RS09160	COG1444	tRNA N-acetyltransferase activity
M1627_RS09210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M1627_RS09215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1627_RS09225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1627_RS09250	COG0475	glutathione-regulated potassium exporter activity
M1627_RS09260	COG0535	radical SAM domain protein
M1627_RS09265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1627_RS09270	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M1627_RS09270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M1627_RS09280	COG0318	PFAM AMP-dependent synthetase and ligase
M1627_RS09285	COG3118	belongs to the thioredoxin family
M1627_RS09290	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1627_RS09305	COG0302	gtp cyclohydrolase
M1627_RS09315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1627_RS09330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1627_RS09395	COG0552	protein localization to endoplasmic reticulum
M1627_RS09410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M1627_RS09430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1627_RS09460	COG0301	tRNA thio-modification
M1627_RS09465	COG1260	myo-inositol-1-phosphate synthase
M1627_RS09470	COG1007	ATP synthesis coupled electron transport
M1627_RS09475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1627_RS09480	COG0713	ATP synthesis coupled electron transport
M1627_RS09490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1627_RS09495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M1627_RS09500	COG0649	NAD binding
M1627_RS09505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1627_RS09515	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M1627_RS09535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1627_RS09540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1627_RS09580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1627_RS09590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M1627_RS09595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M1627_RS09600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M1627_RS09605	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M1627_RS09610	COG1605	Chorismate mutase
M1627_RS09610	COG0077	Prephenate dehydratase
M1627_RS09615	COG3958	Transketolase
M1627_RS09620	COG3959	Transketolase, thiamine diphosphate binding domain
M1627_RS09625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M1627_RS09645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M1627_RS09655	COG1185	polyribonucleotide nucleotidyltransferase activity
M1627_RS09680	COG0477	Major facilitator Superfamily
M1627_RS09690	COG1121	(ABC) transporter
M1627_RS09695	COG1980	fructose-bisphosphate aldolase activity
M1627_RS09720	COG0459	protein refolding
M1627_RS09735	COG0124	histidyl-tRNA synthetase
M1627_RS09770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1627_RS09780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1627_RS09820	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M1627_RS09855	COG1056	cytidyltransferase-related domain
M1627_RS09855	COG1051	belongs to the nudix hydrolase family
M1627_RS09870	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M1627_RS09870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M1627_RS09895	COG0077	Prephenate dehydratase
M1627_RS09895	COG1605	Chorismate mutase
M1627_RS09910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1627_RS09925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1627_RS09940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1627_RS09955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1627_RS09960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M1627_RS09975	COG0105	UTP biosynthetic process
M1627_RS09990	COG0085	RNA polymerase activity
M1627_RS09995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M1627_RS10000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M1627_RS10025	COG0049	tRNA binding
M1627_RS10030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M1627_RS10035	COG0051	transcription antitermination factor activity, RNA binding
M1627_RS10075	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M1627_RS10080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1627_RS10090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1627_RS10110	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M1627_RS10115	COG0504	CTP synthase activity
M1627_RS10130	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
M1627_RS10160	COG2078	PFAM AMMECR1 domain protein
M1627_RS10175	COG0717	Belongs to the dCTP deaminase family
M1627_RS10180	COG1793	dna ligase
M1627_RS10185	COG1793	dna ligase
M1627_RS10185	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M1627_RS10190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1627_RS10215	COG0181	hydroxymethylbilane synthase activity
M1627_RS10220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M1627_RS10225	COG0113	porphobilinogen synthase activity
M1627_RS10230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M1627_RS10250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1627_RS10270	COG0585	pseudouridine synthase activity
M1627_RS10275	COG0017	Asparaginyl-tRNA synthetase
M1627_RS10290	COG0028	Belongs to the TPP enzyme family
M1627_RS10305	COG1122	ATPase activity
M1627_RS10320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1627_RS10335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1627_RS10340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1627_RS10345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1627_RS10350	COG0189	ligase activity
M1627_RS10365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M1627_RS10370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M1627_RS10385	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1627_RS10430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M1627_RS10465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1627_RS10470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1627_RS10520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1627_RS10535	COG1201	RNA secondary structure unwinding
M1627_RS10540	COG0517	IMP dehydrogenase activity
M1627_RS10540	COG0617	tRNA 3'-terminal CCA addition
M1627_RS10540	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M1627_RS10565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1627_RS10570	COG1058	Belongs to the CinA family
M1627_RS10570	COG1546	Belongs to the CinA family
M1627_RS10575	COG2267	carboxylic ester hydrolase activity
M1627_RS10590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M1627_RS10615	COG1078	dGTPase activity
M1627_RS10620	COG0561	phosphatase activity
M1627_RS10625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1627_RS10655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M1627_RS10685	COG1214	PFAM Peptidase M22, glycoprotease
M1627_RS10685	COG0456	acetyltransferase
M1627_RS10700	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1627_RS10715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M1627_RS10720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M1627_RS10725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M1627_RS10735	COG0200	Binds to the 23S rRNA
M1627_RS10740	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M1627_RS10745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1627_RS10755	COG0052	Belongs to the universal ribosomal protein uS2 family
M1627_RS10760	COG1355	regulation of microtubule-based process
M1627_RS10775	COG1304	FMN binding
M1627_RS10830	COG1131	(ABC) transporter
M1627_RS10860	COG0084	hydrolase, TatD family'
M1627_RS10875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1627_RS10920	COG1192	Involved in chromosome partitioning
M1627_RS10940	COG0617	tRNA 3'-terminal CCA addition
M1627_RS10940	COG3620	sequence-specific DNA binding
M1627_RS10940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M1627_RS10950	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M1627_RS10995	COG1201	RNA secondary structure unwinding
M1627_RS11005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1627_RS11030	COG2860	membrane
M1627_RS11045	COG0123	including yeast histone deacetylase and acetoin utilization protein
M1627_RS11065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1627_RS11070	COG0351	phosphomethylpyrimidine kinase
M1627_RS11070	COG0352	thiamine-phosphate diphosphorylase activity
M1627_RS11080	COG1215	transferase activity, transferring glycosyl groups
M1627_RS11130	COG0463	Glycosyl transferase, family 2
M1627_RS11150	COG1063	alcohol dehydrogenase
M1627_RS11170	COG0519	Catalyzes the synthesis of GMP from XMP
M1627_RS11170	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1627_RS11175	COG0501	Belongs to the peptidase M48B family
M1627_RS11180	COG0517	IMP dehydrogenase activity
M1627_RS11180	COG0516	GMP reductase activity
M1627_RS11190	COG1830	Aldolase
M1627_RS11215	COG0405	Gamma-glutamyltransferase
M1627_RS11230	COG1444	tRNA N-acetyltransferase activity
M1627_RS11245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1627_RS11255	COG0656	L-ascorbic acid biosynthetic process
M1627_RS11270	COG0251	oxidation-reduction process
M1627_RS11275	COG0617	tRNA 3'-terminal CCA addition
M1627_RS11275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M1627_RS11275	COG0517	IMP dehydrogenase activity
M1627_RS11280	COG1063	alcohol dehydrogenase
M1627_RS11285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1627_RS11295	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M1627_RS11305	COG4948	Mandelate Racemase Muconate Lactonizing
M1627_RS11310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1627_RS11315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1627_RS11320	COG1012	belongs to the aldehyde dehydrogenase family
M1627_RS11330	COG0243	molybdopterin cofactor binding
M1627_RS11370	COG0833	amino acid
M1627_RS11375	COG0589	response to stress
M1627_RS11390	COG2814	Major facilitator Superfamily
M1627_RS11460	COG1733	regulation of RNA biosynthetic process
M1627_RS11470	COG0516	GMP reductase activity
M1627_RS11470	COG0517	IMP dehydrogenase activity
M1627_RS11475	COG1720	tRNA m6t6A37 methyltransferase activity
M1627_RS11515	COG0277	FAD linked oxidase domain protein
M1627_RS11520	COG0247	lactate metabolic process
M1627_RS11525	COG0095	Lipoate-protein ligase
M1627_RS11530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1627_RS11545	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1627_RS11570	COG0477	Major facilitator Superfamily
M1627_RS11580	COG1960	acyl-CoA dehydrogenase activity
M1627_RS11590	COG2271	Major facilitator Superfamily
M1627_RS11620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M1627_RS11640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1627_RS11650	COG1139	Iron-sulfur cluster binding protein
M1627_RS11655	COG2814	Major facilitator Superfamily
M1627_RS11670	COG4948	Mandelate Racemase Muconate Lactonizing
M1627_RS11680	COG0477	Major facilitator Superfamily
M1627_RS11685	COG2271	Major facilitator Superfamily
M1627_RS11690	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1627_RS11700	COG2267	carboxylic ester hydrolase activity
M1627_RS11710	COG1028	Short-chain dehydrogenase reductase Sdr
M1627_RS11740	COG0805	protein transport
M1627_RS11755	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M1627_RS11795	COG1122	ATPase activity
M1627_RS11835	COG0425	Belongs to the sulfur carrier protein TusA family
M1627_RS11855	COG1131	(ABC) transporter
M1627_RS11915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1627_RS11925	COG3842	ATPase activity
M1627_RS11930	COG0395	ABC-type sugar transport system, permease component
M1627_RS11945	COG0318	PFAM AMP-dependent synthetase and ligase
M1627_RS11980	COG0667	Aldo Keto reductase
M1627_RS12005	COG0673	inositol 2-dehydrogenase activity
M1627_RS12015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1627_RS12020	COG0444	Belongs to the ABC transporter superfamily
M1627_RS12025	COG4608	Belongs to the ABC transporter superfamily
M1627_RS12040	COG3386	PFAM SMP-30 Gluconolaconase
M1627_RS12055	COG3250	beta-galactosidase activity
M1627_RS12070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1627_RS12075	COG1472	Belongs to the glycosyl hydrolase 3 family
M1627_RS12135	COG4948	Mandelate Racemase Muconate Lactonizing
M1627_RS12140	COG3408	Glycogen debranching enzyme
M1627_RS12165	COG1501	Belongs to the glycosyl hydrolase 31 family
M1627_RS12175	COG2723	6-phospho-beta-galactosidase activity
M1627_RS12195	COG0667	Aldo Keto reductase
M1627_RS12205	COG1132	(ABC) transporter
M1627_RS12225	COG0673	inositol 2-dehydrogenase activity
M1627_RS12240	COG1028	Short-chain dehydrogenase reductase Sdr
M1627_RS12255	COG0459	protein refolding
M1627_RS12260	COG4948	Mandelate Racemase Muconate Lactonizing
M1627_RS12265	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1627_RS12270	COG1914	H( )-stimulated, divalent metal cation uptake system
M1627_RS12345	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M1627_RS12365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1627_RS12380	COG2857	Cytochrome c1
M1627_RS12380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M1627_RS12430	COG0601	transmembrane transport
M1627_RS12435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1627_RS12440	COG0444	Belongs to the ABC transporter superfamily
M1627_RS12445	COG4608	Belongs to the ABC transporter superfamily
M1627_RS12520	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
M1627_RS12555	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1627_RS12560	COG1648	precorrin-2 dehydrogenase activity
M1627_RS12560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1627_RS12565	COG2897	thiosulfate sulfurtransferase activity
M1627_RS12595	COG0667	Aldo Keto reductase
M1627_RS12610	COG3608	succinylglutamate desuccinylase aspartoacylase
M1627_RS12610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M1627_RS12620	COG1960	acyl-CoA dehydrogenase activity
M1627_RS12625	COG0318	PFAM AMP-dependent synthetase and ligase
M1627_RS12630	COG0183	Belongs to the thiolase family
M1627_RS12640	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1627_RS12650	COG0281	malic enzyme
M1627_RS12675	COG1584	GPR1 FUN34 yaaH family protein
M1627_RS12680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1627_RS12715	COG0477	Major facilitator Superfamily
M1627_RS12720	COG3842	ATPase activity
M1627_RS12725	COG0395	ABC-type sugar transport system, permease component
M1627_RS12745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1627_RS12785	COG3383	formate dehydrogenase (NAD+) activity
M1627_RS12795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1627_RS12800	COG3848	Pyruvate phosphate dikinase
M1627_RS12800	COG0574	Belongs to the PEP-utilizing enzyme family
M1627_RS12810	COG0644	oxidoreductase
M1627_RS12815	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M1627_RS12820	COG1013	pyruvate-flavodoxin oxidoreductase activity
M1627_RS12825	COG0674	pyruvate-flavodoxin oxidoreductase activity
M1627_RS12825	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M1627_RS12850	COG0318	PFAM AMP-dependent synthetase and ligase
M1627_RS12880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M1627_RS12905	COG1063	alcohol dehydrogenase
M1627_RS12930	COG0243	molybdopterin cofactor binding
M1627_RS12935	COG0437	4 iron, 4 sulfur cluster binding
M1627_RS13025	COG0668	transmembrane transport
M1627_RS13030	COG0586	Pfam SNARE associated Golgi protein
M1627_RS13040	COG0022	dehydrogenase e1 component
M1627_RS13055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1627_RS13060	COG0656	L-ascorbic acid biosynthetic process
M1627_RS13065	COG0589	response to stress
M1627_RS13075	COG0644	oxidoreductase
M1627_RS13090	COG0028	Belongs to the TPP enzyme family
M1627_RS13105	COG0402	S-adenosylhomocysteine deaminase activity
M1627_RS13125	COG0492	ferredoxin-NADP+ reductase activity
M1627_RS13135	COG2086	electron transfer activity
M1627_RS13145	COG1960	acyl-CoA dehydrogenase activity
M1627_RS13160	COG0437	4 iron, 4 sulfur cluster binding
M1627_RS13165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M1627_RS13170	COG1144	Oxidoreductase
M1627_RS13175	COG0674	pyruvate-flavodoxin oxidoreductase activity
M1627_RS13180	COG1013	pyruvate-flavodoxin oxidoreductase activity
M1627_RS13185	COG0438	transferase activity, transferring glycosyl groups
M1627_RS13190	COG3387	PFAM Glycoside hydrolase 15-related
M1627_RS13245	COG3387	PFAM Glycoside hydrolase 15-related
M1627_RS13255	COG0517	IMP dehydrogenase activity
M1627_RS13265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1627_RS13325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1627_RS13335	COG2814	Major facilitator Superfamily
M1627_RS13350	COG0395	ABC-type sugar transport system, permease component
M1627_RS13355	COG3842	ATPase activity
M1627_RS13385	COG0813	purine-nucleoside phosphorylase activity
M1627_RS13390	COG3386	PFAM SMP-30 Gluconolaconase
M1627_RS13395	COG2814	Major facilitator Superfamily
M1627_RS13440	COG4274	PFAM GYD family protein
M1627_RS13450	COG1506	peptidase
M1627_RS13450	COG4946	Tricorn protease homolog
M1627_RS13450	COG0823	Involved in the tonB-independent uptake of proteins
M1627_RS13475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1627_RS13560	COG4608	Belongs to the ABC transporter superfamily
M1627_RS13565	COG0444	Belongs to the ABC transporter superfamily
M1627_RS13580	COG0601	transmembrane transport
M1627_RS13595	COG4948	Mandelate Racemase Muconate Lactonizing
M1627_RS13600	COG1028	Short-chain dehydrogenase reductase Sdr
M1627_RS13655	COG2217	Heavy metal translocating P-type atpase
M1627_RS13665	COG4555	ABC transporter
M1627_RS13690	COG1592	Rubrerythrin
M1627_RS13725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1627_RS13775	COG0183	Belongs to the thiolase family
M1627_RS13785	COG1024	Enoyl-CoA hydratase
M1627_RS13810	COG0601	transmembrane transport
M1627_RS13815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1627_RS13820	COG0444	Belongs to the ABC transporter superfamily
M1627_RS13825	COG4608	Belongs to the ABC transporter superfamily
M1627_RS13835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1627_RS13840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1627_RS13855	COG0438	transferase activity, transferring glycosyl groups
M1627_RS13875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1627_RS13900	COG1131	(ABC) transporter
M1627_RS13905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1627_RS13915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1627_RS13935	COG0149	triose-phosphate isomerase activity
M1627_RS13950	COG0372	Belongs to the citrate synthase family
M1627_RS13955	COG0516	GMP reductase activity
M1627_RS13955	COG0517	IMP dehydrogenase activity
M1627_RS13960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M1627_RS13965	COG2079	MmgE PrpD family protein
M1627_RS13970	COG0039	L-malate dehydrogenase activity
M1627_RS13975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1627_RS14025	COG1489	DNA binding
M1627_RS14055	COG0778	Nitroreductase
M1627_RS14060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1627_RS14190	COG0308	aminopeptidase N
M1627_RS14205	COG0561	phosphatase activity
M1627_RS14215	COG1011	Hydrolase
M1627_RS14230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M1627_RS14260	COG0494	nUDIX hydrolase
M1627_RS14270	COG3253	May function as heme-dependent peroxidase
M1627_RS14285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1627_RS14315	COG2226	methyltransferase
M1627_RS14340	COG0538	isocitrate dehydrogenase activity
M1627_RS14510	COG0393	Putative heavy-metal-binding
M1627_RS14555	COG1305	Transglutaminase-like
M1627_RS14780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate