locus-tag	class	description
M164_RS00025	COG2154	pterin-4-alpha-carbinolamine dehydratase
M164_RS00105	COG1331	Highly conserved protein containing a thioredoxin domain
M164_RS00115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M164_RS00125	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
M164_RS00150	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M164_RS00165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M164_RS00175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M164_RS00180	COG2814	Major facilitator Superfamily
M164_RS00190	COG0492	ferredoxin-NADP+ reductase activity
M164_RS00260	COG0588	phosphoglycerate mutase activity
M164_RS00280	COG1957	nucleoside hydrolase
M164_RS00330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M164_RS00330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M164_RS00335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M164_RS00340	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
M164_RS00360	COG0596	Alpha beta hydrolase
M164_RS00375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M164_RS00415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M164_RS00420	COG1573	uracil-dna glycosylase
M164_RS00425	COG1028	Short-chain dehydrogenase reductase Sdr
M164_RS00450	COG0215	cysteine-tRNA ligase activity
M164_RS00455	COG2222	sugar isomerase
M164_RS00465	COG0446	pyridine nucleotide-disulphide oxidoreductase
M164_RS00475	COG0433	COG0433 Predicted ATPase
M164_RS00485	COG1607	acyl-coa hydrolase
M164_RS00495	COG1028	Short-chain dehydrogenase reductase Sdr
M164_RS00500	COG0708	Exodeoxyribonuclease III
M164_RS00505	COG0515	serine threonine protein kinase
M164_RS00505	COG2815	serine threonine protein kinase
M164_RS00550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M164_RS00550	COG1648	precorrin-2 dehydrogenase activity
M164_RS00560	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
M164_RS00580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M164_RS00590	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
M164_RS00780	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M164_RS00785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M164_RS00800	COG0189	ligase activity
M164_RS00810	COG0493	'glutamate synthase
M164_RS00840	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M164_RS00860	COG1053	succinate dehydrogenase
M164_RS00880	COG2304	oxidoreductase activity
M164_RS00885	COG0714	Associated with various cellular activities
M164_RS00905	COG0083	homoserine kinase activity
M164_RS00910	COG0626	cystathionine gamma-synthase activity
M164_RS00950	COG0183	Belongs to the thiolase family
M164_RS00955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M164_RS00995	COG1215	transferase activity, transferring glycosyl groups
M164_RS01000	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M164_RS01010	COG0351	phosphomethylpyrimidine kinase
M164_RS01015	COG0314	molybdopterin synthase activity
M164_RS01040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M164_RS01050	COG1131	(ABC) transporter
M164_RS01055	COG1668	transmembrane transport
M164_RS01080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M164_RS01085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M164_RS01110	COG0720	synthase
M164_RS01125	COG0492	ferredoxin-NADP+ reductase activity
M164_RS01135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M164_RS01155	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M164_RS01155	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M164_RS01165	COG0071	Belongs to the small heat shock protein (HSP20) family
M164_RS01225	COG0402	S-adenosylhomocysteine deaminase activity
M164_RS01250	COG0430	RNA-3'-phosphate cyclase activity
M164_RS01260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M164_RS01265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M164_RS01270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M164_RS01280	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M164_RS01290	COG1515	deoxyribonuclease V activity
M164_RS01295	COG1335	isochorismatase
M164_RS01330	COG4581	dead DEAH box helicase
M164_RS01340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M164_RS01350	COG0439	Biotin carboxylase
M164_RS01360	COG1116	anion transmembrane transporter activity
M164_RS01370	COG0066	3-isopropylmalate dehydratase activity
M164_RS01375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M164_RS01380	COG0415	Belongs to the DNA photolyase family
M164_RS01415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M164_RS01430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M164_RS01435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M164_RS01450	COG0045	succinate-CoA ligase (ADP-forming) activity
M164_RS01500	COG0657	acetylesterase activity
M164_RS01505	COG1063	alcohol dehydrogenase
M164_RS01510	COG0183	Belongs to the thiolase family
M164_RS01515	COG1960	acyl-CoA dehydrogenase activity
M164_RS01520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M164_RS01525	COG1028	Short-chain dehydrogenase reductase Sdr
M164_RS01530	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M164_RS01570	COG0318	PFAM AMP-dependent synthetase and ligase
M164_RS01575	COG1960	acyl-CoA dehydrogenase activity
M164_RS01580	COG1024	Enoyl-CoA hydratase
M164_RS01585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M164_RS01590	COG2814	Major facilitator Superfamily
M164_RS01590	COG0477	Major facilitator Superfamily
M164_RS01625	COG0657	acetylesterase activity
M164_RS01635	COG0318	PFAM AMP-dependent synthetase and ligase
M164_RS01645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M164_RS01775	COG0432	Pfam Uncharacterised protein family UPF0047
M164_RS01780	COG1305	Transglutaminase-like
M164_RS01790	COG1522	sequence-specific DNA binding
M164_RS01795	COG1013	pyruvate-flavodoxin oxidoreductase activity
M164_RS01800	COG0674	pyruvate-flavodoxin oxidoreductase activity
M164_RS01815	COG1620	l-lactate permease
M164_RS01820	COG1487	ribonuclease activity
M164_RS01830	COG2226	methyltransferase
M164_RS01845	COG0450	alkyl hydroperoxide reductase
M164_RS01905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M164_RS01910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M164_RS01920	COG2062	phosphohistidine phosphatase, SixA
M164_RS01935	COG0674	pyruvate-flavodoxin oxidoreductase activity
M164_RS01980	COG0277	FAD linked oxidase domain protein
M164_RS02000	COG1012	belongs to the aldehyde dehydrogenase family
M164_RS02050	COG3350	monooxygenase activity
M164_RS02075	COG2151	metal-sulfur cluster biosynthetic enzyme
M164_RS02080	COG0028	Belongs to the TPP enzyme family
M164_RS02090	COG1741	Belongs to the pirin family
M164_RS02105	COG1024	Enoyl-CoA hydratase
M164_RS02115	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
M164_RS02145	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M164_RS02145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M164_RS02155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M164_RS02190	COG1017	nitric oxide dioxygenase activity
M164_RS02225	COG4608	Belongs to the ABC transporter superfamily
M164_RS02230	COG0444	Belongs to the ABC transporter superfamily
M164_RS02240	COG0601	transmembrane transport
M164_RS02255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M164_RS02270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M164_RS02275	COG1131	(ABC) transporter
M164_RS02300	COG2721	sulfolactate sulfo-lyase activity
M164_RS02305	COG2721	sulfolactate sulfo-lyase activity
M164_RS02320	COG1802	Transcriptional regulator
M164_RS02325	COG2301	Belongs to the HpcH HpaI aldolase family
M164_RS02330	COG2050	protein possibly involved in aromatic compounds catabolism
M164_RS02330	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M164_RS02340	COG0598	Magnesium transport protein CorA
M164_RS02375	COG2084	Dehydrogenase
M164_RS02480	COG0412	Dienelactone hydrolase
M164_RS02525	COG4946	Tricorn protease homolog
M164_RS02525	COG0793	Belongs to the peptidase S41A family
M164_RS02530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M164_RS02605	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M164_RS02630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M164_RS02650	COG1960	acyl-CoA dehydrogenase activity
M164_RS02655	COG0318	PFAM AMP-dependent synthetase and ligase
M164_RS02670	COG2814	Major facilitator Superfamily
M164_RS02685	COG1725	Transcriptional regulator
M164_RS02720	COG0243	molybdopterin cofactor binding
M164_RS02805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M164_RS02885	COG1953	Uracil, thiamine, allantoin
M164_RS02925	COG2814	Major facilitator Superfamily
M164_RS02930	COG4948	Mandelate Racemase Muconate Lactonizing
M164_RS02965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M164_RS02970	COG0477	Major facilitator Superfamily
M164_RS02980	COG1028	Short-chain dehydrogenase reductase Sdr
M164_RS03000	COG0675	Transposase, IS605 OrfB family
M164_RS03095	COG1401	restriction endodeoxyribonuclease activity
M164_RS03115	COG1091	dTDP-4-dehydrorhamnose reductase activity
M164_RS03120	COG3511	phospholipase C
M164_RS03145	COG0438	transferase activity, transferring glycosyl groups
M164_RS03160	COG1215	transferase activity, transferring glycosyl groups
M164_RS03165	COG0438	transferase activity, transferring glycosyl groups
M164_RS03180	COG1215	transferase activity, transferring glycosyl groups
M164_RS03185	COG0438	transferase activity, transferring glycosyl groups
M164_RS03190	COG0438	transferase activity, transferring glycosyl groups
M164_RS03200	COG0438	transferase activity, transferring glycosyl groups
M164_RS03245	COG1216	Glycosyl transferase, family 2
M164_RS03275	COG0463	Glycosyl transferase, family 2
M164_RS03280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M164_RS03285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M164_RS03305	COG0463	Glycosyl transferase, family 2
M164_RS03360	COG2224	Isocitrate lyase
M164_RS03365	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M164_RS03375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M164_RS03380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M164_RS03390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M164_RS03390	COG2146	nitrite reductase [NAD(P)H] activity
M164_RS03420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M164_RS03425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M164_RS03430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M164_RS03470	COG1960	acyl-CoA dehydrogenase activity
M164_RS03475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M164_RS03485	COG2271	Major facilitator Superfamily
M164_RS03490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M164_RS03500	COG2368	4-hydroxyphenylacetate
M164_RS03560	COG0477	Major facilitator Superfamily
M164_RS03585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M164_RS03590	COG0531	amino acid
M164_RS03595	COG1953	Uracil, thiamine, allantoin
M164_RS03600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M164_RS03610	COG0477	Major facilitator Superfamily
M164_RS03655	COG1011	Hydrolase
M164_RS03685	COG0582	viral genome integration into host DNA
M164_RS03775	COG1024	Enoyl-CoA hydratase
M164_RS03785	COG0425	Belongs to the sulfur carrier protein TusA family
M164_RS03820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M164_RS03820	COG0045	succinate-CoA ligase (ADP-forming) activity
M164_RS03820	COG1042	CoA-binding domain protein
M164_RS03840	COG2226	methyltransferase
M164_RS03855	COG0577	efflux transmembrane transporter activity
M164_RS03925	COG2151	metal-sulfur cluster biosynthetic enzyme
M164_RS03930	COG0589	response to stress
M164_RS03945	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M164_RS03955	COG0501	Belongs to the peptidase M48B family
M164_RS04075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M164_RS04085	COG2002	toxin-antitoxin pair type II binding
M164_RS04095	COG1073	alpha beta
M164_RS04105	COG0318	PFAM AMP-dependent synthetase and ligase
M164_RS04120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M164_RS04135	COG4689	acetoacetate decarboxylase
M164_RS04140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M164_RS04150	COG2271	Major facilitator Superfamily
M164_RS04155	COG4948	Mandelate Racemase Muconate Lactonizing
M164_RS04160	COG0318	PFAM AMP-dependent synthetase and ligase
M164_RS04165	COG2030	dehydratase
M164_RS04190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M164_RS04200	COG1960	acyl-CoA dehydrogenase activity
M164_RS04205	COG0095	Lipoate-protein ligase
M164_RS04215	COG1250	3-hydroxyacyl-CoA dehydrogenase
M164_RS04220	COG0318	PFAM AMP-dependent synthetase and ligase
M164_RS04230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M164_RS04235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M164_RS04240	COG0022	dehydrogenase e1 component
M164_RS04245	COG3199	ATP-NAD kinase
M164_RS04250	COG0508	dehydrogenase complex catalyzes the overall conversion of
M164_RS04290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M164_RS04400	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M164_RS04540	COG1373	ATPase (AAA superfamily
M164_RS04590	COG1473	amidohydrolase
M164_RS04610	COG0675	Transposase, IS605 OrfB family
M164_RS04655	COG1131	(ABC) transporter
M164_RS04670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M164_RS04675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M164_RS04700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M164_RS04730	COG0598	Magnesium transport protein CorA
M164_RS04800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M164_RS04810	COG0675	Transposase, IS605 OrfB family
M164_RS04845	COG0463	Glycosyl transferase, family 2
M164_RS04945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M164_RS05030	COG1012	belongs to the aldehyde dehydrogenase family
M164_RS05035	COG0535	radical SAM domain protein
M164_RS05040	COG0535	radical SAM domain protein
M164_RS05110	COG2271	Major facilitator Superfamily
M164_RS05155	COG1175	transmembrane transport
M164_RS05160	COG3833	ABC-type maltose transport systems, permease component
M164_RS05165	COG3842	ATPase activity
M164_RS05175	COG2814	Major facilitator Superfamily
M164_RS05210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M164_RS05230	COG1960	acyl-CoA dehydrogenase activity
M164_RS05265	COG0477	Major facilitator Superfamily
M164_RS05270	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
M164_RS05275	COG1131	(ABC) transporter
M164_RS05300	COG0475	glutathione-regulated potassium exporter activity
M164_RS05315	COG2048	Heterodisulfide reductase, subunit B
M164_RS05345	COG0425	Belongs to the sulfur carrier protein TusA family
M164_RS05350	COG2210	Belongs to the sulfur carrier protein TusA family
M164_RS05395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M164_RS05405	COG0095	Lipoate-protein ligase
M164_RS05410	COG1832	CoA-binding protein
M164_RS05440	COG0509	glycine decarboxylation via glycine cleavage system
M164_RS05450	COG2271	Major facilitator Superfamily
M164_RS05490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M164_RS05535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M164_RS05545	COG1846	Transcriptional regulator
M164_RS05550	COG1136	(ABC) transporter
M164_RS05550	COG0577	efflux transmembrane transporter activity
M164_RS05560	COG1136	(ABC) transporter
M164_RS05565	COG0114	fumarate hydratase activity
M164_RS05575	COG0517	IMP dehydrogenase activity
M164_RS05580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M164_RS05580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M164_RS05585	COG0531	amino acid
M164_RS05595	COG2005	Transcriptional regulator
M164_RS05600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M164_RS05605	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M164_RS05625	COG0509	glycine decarboxylation via glycine cleavage system
M164_RS05665	COG0004	ammonium transporteR
M164_RS05685	COG1185	polyribonucleotide nucleotidyltransferase activity
M164_RS05730	COG1234	tRNA 3'-trailer cleavage
M164_RS05745	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M164_RS05780	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M164_RS05785	COG0725	ABC transporter, periplasmic molybdate-binding protein
M164_RS05790	COG0300	oxidoreductase activity
M164_RS05820	COG0650	Formate hydrogenlyase subunit 4
M164_RS05830	COG0651	ATP synthesis coupled electron transport
M164_RS05835	COG0649	NAD binding
M164_RS05840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M164_RS05845	COG0651	ATP synthesis coupled electron transport
M164_RS05855	COG2897	thiosulfate sulfurtransferase activity
M164_RS05860	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M164_RS05875	COG0028	Belongs to the TPP enzyme family
M164_RS05880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M164_RS05925	COG0395	ABC-type sugar transport system, permease component
M164_RS05940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M164_RS05945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M164_RS05950	COG0157	Belongs to the NadC ModD family
M164_RS05980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M164_RS05990	COG0297	glycogen (starch) synthase activity
M164_RS06000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M164_RS06040	COG0469	pyruvate kinase activity
M164_RS06055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M164_RS06065	COG0528	UMP kinase activity
M164_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
M164_RS06090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M164_RS06095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M164_RS06105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M164_RS06135	COG1110	DNA topoisomerase II activity
M164_RS06175	COG0154	amidase activity
M164_RS06190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M164_RS06190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M164_RS06245	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
M164_RS06275	COG0252	asparaginase activity
M164_RS06280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M164_RS06310	COG1372	Participates in initiation and elongation during chromosome replication
M164_RS06310	COG0719	Fe-S assembly protein
M164_RS06315	COG0719	Fe-S assembly protein
M164_RS06320	COG0396	ATPase activity
M164_RS06340	COG0509	glycine decarboxylation via glycine cleavage system
M164_RS06345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M164_RS06355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M164_RS06375	COG0148	phosphopyruvate hydratase activity
M164_RS06395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M164_RS06400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M164_RS06415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M164_RS06445	COG0644	oxidoreductase
M164_RS06450	COG0525	valine-tRNA ligase activity
M164_RS06455	COG0436	Aminotransferase
M164_RS06460	COG0134	indole-3-glycerol-phosphate synthase activity
M164_RS06465	COG0512	Glutamine amidotransferase of anthranilate synthase
M164_RS06465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M164_RS06470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M164_RS06475	COG0135	phosphoribosylanthranilate isomerase activity
M164_RS06485	COG0159	tryptophan synthase activity
M164_RS06490	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
M164_RS06495	COG1254	Belongs to the acylphosphatase family
M164_RS06500	COG1260	myo-inositol-1-phosphate synthase
M164_RS06505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M164_RS06505	COG0574	Belongs to the PEP-utilizing enzyme family
M164_RS06525	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M164_RS06530	COG0527	aspartate kinase activity
M164_RS06530	COG0460	homoserine dehydrogenase
M164_RS06550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M164_RS06585	COG0459	protein refolding
M164_RS06675	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M164_RS06735	COG0315	cyclic pyranopterin monophosphate synthase activity
M164_RS06740	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M164_RS06745	COG2255	four-way junction helicase activity
M164_RS06750	COG1881	PFAM PEBP family protein
M164_RS06755	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M164_RS06765	COG1063	alcohol dehydrogenase
M164_RS06790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M164_RS06800	COG1047	Peptidyl-prolyl cis-trans
M164_RS06815	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M164_RS06830	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M164_RS06875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M164_RS06880	COG2264	protein methyltransferase activity
M164_RS06885	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
M164_RS06895	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M164_RS06940	COG1185	polyribonucleotide nucleotidyltransferase activity
M164_RS06965	COG0322	excinuclease ABC activity
M164_RS06970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M164_RS06990	COG0473	3-isopropylmalate dehydrogenase activity
M164_RS06995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M164_RS07005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M164_RS07020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M164_RS07025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M164_RS07030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M164_RS07035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M164_RS07040	COG0255	Belongs to the universal ribosomal protein uL29 family
M164_RS07050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M164_RS07055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M164_RS07060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M164_RS07070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M164_RS07080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M164_RS07085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M164_RS07105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M164_RS07140	COG0563	adenylate kinase activity
M164_RS07190	COG1136	(ABC) transporter
M164_RS07190	COG0577	efflux transmembrane transporter activity
M164_RS07200	COG0069	glutamate synthase activity
M164_RS07205	COG0067	glutamate synthase
M164_RS07220	COG0402	S-adenosylhomocysteine deaminase activity
M164_RS07235	COG0303	'Molybdopterin
M164_RS07250	COG2226	methyltransferase
M164_RS07270	COG1321	iron dependent repressor
M164_RS07280	COG2379	hydroxypyruvate reductase
M164_RS07285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M164_RS07290	COG0009	L-threonylcarbamoyladenylate synthase
M164_RS07300	COG0312	modulator of DNA gyrase
M164_RS07305	COG0312	modulator of DNA gyrase
M164_RS07310	COG0864	Transcriptional regulator
M164_RS07320	COG0460	homoserine dehydrogenase
M164_RS07335	COG1024	Enoyl-CoA hydratase
M164_RS07375	COG1250	3-hydroxyacyl-CoA dehydrogenase
M164_RS07385	COG0189	ligase activity
M164_RS07395	COG0505	Belongs to the CarA family
M164_RS07400	COG0165	Argininosuccinate lyase
M164_RS07405	COG0137	argininosuccinate synthase activity
M164_RS07420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M164_RS07425	COG0151	Belongs to the GarS family
M164_RS07430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M164_RS07435	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M164_RS07445	COG0047	phosphoribosylformylglycinamidine synthase activity
M164_RS07455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M164_RS07460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M164_RS07460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M164_RS07465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M164_RS07470	COG0602	queuosine metabolic process
M164_RS07505	COG0284	orotidine-5'-phosphate decarboxylase activity
M164_RS07510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M164_RS07515	COG0540	Belongs to the ATCase OTCase family
M164_RS07520	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
M164_RS07535	COG0167	dihydroorotate dehydrogenase activity
M164_RS07550	COG2095	MarC family integral membrane protein
M164_RS07555	COG1522	sequence-specific DNA binding
M164_RS07570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M164_RS07575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M164_RS07580	COG2151	metal-sulfur cluster biosynthetic enzyme
M164_RS07590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M164_RS07595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M164_RS07595	COG0140	phosphoribosyl-ATP diphosphatase activity
M164_RS07600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M164_RS07605	COG0107	imidazoleglycerol-phosphate synthase activity
M164_RS07610	COG0131	Imidazoleglycerol-phosphate dehydratase
M164_RS07615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M164_RS07620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M164_RS07625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M164_RS07635	COG0495	leucyl-tRNA aminoacylation
M164_RS07640	COG2096	Adenosyltransferase
M164_RS07645	COG0037	tRNA processing
M164_RS07655	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M164_RS07680	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M164_RS07690	COG0028	Belongs to the TPP enzyme family
M164_RS07700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M164_RS07715	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M164_RS07720	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M164_RS07730	COG0442	prolyl-tRNA aminoacylation
M164_RS07745	COG1394	ATPase activity, coupled to movement of substances
M164_RS07755	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
M164_RS07775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M164_RS07805	COG0417	DNA replication proofreading
M164_RS07820	COG0668	transmembrane transport
M164_RS07830	COG0126	phosphoglycerate kinase activity
M164_RS07840	COG0589	response to stress
M164_RS07845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M164_RS07865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M164_RS07870	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M164_RS08085	COG1192	Involved in chromosome partitioning
M164_RS08200	COG0495	leucyl-tRNA aminoacylation
M164_RS08250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M164_RS08265	COG0581	inorganic phosphate transmembrane transporter activity
M164_RS08280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M164_RS08285	COG1121	(ABC) transporter
M164_RS08290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M164_RS08300	COG0805	protein transport
M164_RS08310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M164_RS08335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M164_RS08345	COG0556	nucleotide-excision repair
M164_RS08350	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M164_RS08360	COG3276	selenocysteine insertion sequence binding
M164_RS08380	COG0351	phosphomethylpyrimidine kinase
M164_RS08380	COG1992	Thiamine-phosphate synthase
M164_RS08410	COG0489	protein tyrosine kinase activity
M164_RS08430	COG1280	lysine exporter protein (LysE YggA)
M164_RS08460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M164_RS08470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M164_RS08510	COG0423	glycine-tRNA ligase activity
M164_RS08540	COG0163	prenyltransferase activity
M164_RS08545	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
M164_RS08565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M164_RS08570	COG0667	Aldo Keto reductase
M164_RS08615	COG1110	DNA topoisomerase II activity
M164_RS08620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M164_RS08625	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
M164_RS08640	COG0539	negative regulation of cytoplasmic translation
M164_RS08670	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M164_RS08685	COG1797	cobyrinic acid a,c-diamide synthase activity
M164_RS08705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M164_RS08715	COG0402	S-adenosylhomocysteine deaminase activity
M164_RS08735	COG1201	RNA secondary structure unwinding
M164_RS08750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M164_RS08755	COG2813	Specifically methylates the guanine in position
M164_RS08765	COG1444	tRNA N-acetyltransferase activity
M164_RS08810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M164_RS08815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M164_RS08825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M164_RS08850	COG0475	glutathione-regulated potassium exporter activity
M164_RS08860	COG0535	radical SAM domain protein
M164_RS08865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M164_RS08870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M164_RS08870	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M164_RS08880	COG0318	PFAM AMP-dependent synthetase and ligase
M164_RS08885	COG3118	belongs to the thioredoxin family
M164_RS08890	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M164_RS08905	COG0302	gtp cyclohydrolase
M164_RS08915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M164_RS08930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M164_RS08995	COG0552	protein localization to endoplasmic reticulum
M164_RS09010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M164_RS09020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M164_RS09030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M164_RS09060	COG0301	tRNA thio-modification
M164_RS09065	COG1260	myo-inositol-1-phosphate synthase
M164_RS09070	COG1007	ATP synthesis coupled electron transport
M164_RS09075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M164_RS09080	COG0713	ATP synthesis coupled electron transport
M164_RS09090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M164_RS09095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M164_RS09100	COG0649	NAD binding
M164_RS09105	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M164_RS09115	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M164_RS09135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M164_RS09140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M164_RS09180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M164_RS09190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M164_RS09195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M164_RS09200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M164_RS09205	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M164_RS09210	COG1605	Chorismate mutase
M164_RS09210	COG0077	Prephenate dehydratase
M164_RS09215	COG3958	Transketolase
M164_RS09220	COG3959	Transketolase, thiamine diphosphate binding domain
M164_RS09225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M164_RS09245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M164_RS09255	COG1185	polyribonucleotide nucleotidyltransferase activity
M164_RS09280	COG0477	Major facilitator Superfamily
M164_RS09290	COG1121	(ABC) transporter
M164_RS09295	COG1980	fructose-bisphosphate aldolase activity
M164_RS09320	COG0459	protein refolding
M164_RS09335	COG0124	histidyl-tRNA synthetase
M164_RS09370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M164_RS09380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M164_RS09420	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M164_RS09455	COG1051	belongs to the nudix hydrolase family
M164_RS09455	COG1056	cytidyltransferase-related domain
M164_RS09470	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M164_RS09470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M164_RS09495	COG0077	Prephenate dehydratase
M164_RS09495	COG1605	Chorismate mutase
M164_RS09510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M164_RS09525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M164_RS09540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M164_RS09555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M164_RS09560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M164_RS09575	COG0105	UTP biosynthetic process
M164_RS09590	COG0085	RNA polymerase activity
M164_RS09595	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M164_RS09600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M164_RS09625	COG0049	tRNA binding
M164_RS09630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M164_RS09635	COG0051	transcription antitermination factor activity, RNA binding
M164_RS09675	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M164_RS09680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M164_RS09690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M164_RS09710	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M164_RS09715	COG0504	CTP synthase activity
M164_RS09730	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
M164_RS09760	COG2078	PFAM AMMECR1 domain protein
M164_RS09775	COG0717	Belongs to the dCTP deaminase family
M164_RS09780	COG1793	dna ligase
M164_RS09785	COG1793	dna ligase
M164_RS09785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M164_RS09790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M164_RS09815	COG0181	hydroxymethylbilane synthase activity
M164_RS09820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M164_RS09825	COG0113	porphobilinogen synthase activity
M164_RS09830	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M164_RS09850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M164_RS09870	COG0585	pseudouridine synthase activity
M164_RS09875	COG0017	Asparaginyl-tRNA synthetase
M164_RS09890	COG0028	Belongs to the TPP enzyme family
M164_RS09905	COG1122	ATPase activity
M164_RS09930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M164_RS09935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M164_RS09940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M164_RS09945	COG0189	ligase activity
M164_RS09960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M164_RS09965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M164_RS09980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M164_RS10025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M164_RS10060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M164_RS10065	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M164_RS10115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M164_RS10130	COG1201	RNA secondary structure unwinding
M164_RS10135	COG0517	IMP dehydrogenase activity
M164_RS10135	COG0617	tRNA 3'-terminal CCA addition
M164_RS10135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M164_RS10160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M164_RS10165	COG1546	Belongs to the CinA family
M164_RS10165	COG1058	Belongs to the CinA family
M164_RS10170	COG2267	carboxylic ester hydrolase activity
M164_RS10185	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M164_RS10210	COG1078	dGTPase activity
M164_RS10215	COG0561	phosphatase activity
M164_RS10220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M164_RS10230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M164_RS10260	COG1214	PFAM Peptidase M22, glycoprotease
M164_RS10260	COG0456	acetyltransferase
M164_RS10275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M164_RS10290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M164_RS10295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M164_RS10300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M164_RS10310	COG0200	Binds to the 23S rRNA
M164_RS10315	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M164_RS10320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M164_RS10330	COG0052	Belongs to the universal ribosomal protein uS2 family
M164_RS10335	COG1355	regulation of microtubule-based process
M164_RS10350	COG1304	FMN binding
M164_RS10405	COG1131	(ABC) transporter
M164_RS10435	COG0084	hydrolase, TatD family'
M164_RS10450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M164_RS10485	COG1192	Involved in chromosome partitioning
M164_RS10505	COG3620	sequence-specific DNA binding
M164_RS10505	COG0617	tRNA 3'-terminal CCA addition
M164_RS10505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M164_RS10515	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M164_RS10560	COG1201	RNA secondary structure unwinding
M164_RS10570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M164_RS10595	COG2860	membrane
M164_RS10610	COG0123	including yeast histone deacetylase and acetoin utilization protein
M164_RS10630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M164_RS10635	COG0351	phosphomethylpyrimidine kinase
M164_RS10635	COG0352	thiamine-phosphate diphosphorylase activity
M164_RS10645	COG1215	transferase activity, transferring glycosyl groups
M164_RS10695	COG0463	Glycosyl transferase, family 2
M164_RS10715	COG1063	alcohol dehydrogenase
M164_RS10735	COG0519	Catalyzes the synthesis of GMP from XMP
M164_RS10735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M164_RS10740	COG0501	Belongs to the peptidase M48B family
M164_RS10745	COG0516	GMP reductase activity
M164_RS10745	COG0517	IMP dehydrogenase activity
M164_RS10755	COG1830	Aldolase
M164_RS10780	COG0405	Gamma-glutamyltransferase
M164_RS10795	COG1444	tRNA N-acetyltransferase activity
M164_RS10810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M164_RS10820	COG0656	L-ascorbic acid biosynthetic process
M164_RS10835	COG0251	oxidation-reduction process
M164_RS10840	COG0517	IMP dehydrogenase activity
M164_RS10840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M164_RS10840	COG0617	tRNA 3'-terminal CCA addition
M164_RS10845	COG1063	alcohol dehydrogenase
M164_RS10850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M164_RS10860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M164_RS10870	COG4948	Mandelate Racemase Muconate Lactonizing
M164_RS10875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M164_RS10880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M164_RS10885	COG1012	belongs to the aldehyde dehydrogenase family
M164_RS10895	COG0243	molybdopterin cofactor binding
M164_RS10935	COG0833	amino acid
M164_RS10940	COG0589	response to stress
M164_RS10955	COG2814	Major facilitator Superfamily
M164_RS11025	COG1733	regulation of RNA biosynthetic process
M164_RS11035	COG0516	GMP reductase activity
M164_RS11035	COG0517	IMP dehydrogenase activity
M164_RS11040	COG1720	tRNA m6t6A37 methyltransferase activity
M164_RS11080	COG0277	FAD linked oxidase domain protein
M164_RS11085	COG0247	lactate metabolic process
M164_RS11090	COG0095	Lipoate-protein ligase
M164_RS11095	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M164_RS11110	COG0655	NAD(P)H dehydrogenase (quinone) activity
M164_RS11135	COG0477	Major facilitator Superfamily
M164_RS11145	COG1960	acyl-CoA dehydrogenase activity
M164_RS11155	COG2271	Major facilitator Superfamily
M164_RS11185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M164_RS11205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M164_RS11215	COG1139	Iron-sulfur cluster binding protein
M164_RS11220	COG2814	Major facilitator Superfamily
M164_RS11235	COG4948	Mandelate Racemase Muconate Lactonizing
M164_RS11245	COG0477	Major facilitator Superfamily
M164_RS11250	COG2271	Major facilitator Superfamily
M164_RS11255	COG0179	Fumarylacetoacetate (FAA) hydrolase
M164_RS11265	COG2267	carboxylic ester hydrolase activity
M164_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
M164_RS11305	COG0805	protein transport
M164_RS11320	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M164_RS11360	COG1122	ATPase activity
M164_RS11400	COG0425	Belongs to the sulfur carrier protein TusA family
M164_RS11420	COG1131	(ABC) transporter
M164_RS11485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M164_RS11495	COG3842	ATPase activity
M164_RS11500	COG0395	ABC-type sugar transport system, permease component
M164_RS11515	COG0318	PFAM AMP-dependent synthetase and ligase
M164_RS11550	COG0667	Aldo Keto reductase
M164_RS11575	COG0673	inositol 2-dehydrogenase activity
M164_RS11585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M164_RS11590	COG0444	Belongs to the ABC transporter superfamily
M164_RS11595	COG4608	Belongs to the ABC transporter superfamily
M164_RS11610	COG3386	PFAM SMP-30 Gluconolaconase
M164_RS11625	COG3250	beta-galactosidase activity
M164_RS11640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M164_RS11645	COG1472	Belongs to the glycosyl hydrolase 3 family
M164_RS11700	COG4948	Mandelate Racemase Muconate Lactonizing
M164_RS11705	COG3408	Glycogen debranching enzyme
M164_RS11730	COG1501	Belongs to the glycosyl hydrolase 31 family
M164_RS11740	COG2723	6-phospho-beta-galactosidase activity
M164_RS11760	COG0667	Aldo Keto reductase
M164_RS11770	COG1132	(ABC) transporter
M164_RS11790	COG0673	inositol 2-dehydrogenase activity
M164_RS11805	COG1028	Short-chain dehydrogenase reductase Sdr
M164_RS11820	COG0459	protein refolding
M164_RS11825	COG4948	Mandelate Racemase Muconate Lactonizing
M164_RS11830	COG1250	3-hydroxyacyl-CoA dehydrogenase
M164_RS11835	COG1914	H( )-stimulated, divalent metal cation uptake system
M164_RS11910	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M164_RS11930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M164_RS11945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M164_RS11945	COG2857	Cytochrome c1
M164_RS11995	COG0601	transmembrane transport
M164_RS12000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M164_RS12005	COG0444	Belongs to the ABC transporter superfamily
M164_RS12010	COG4608	Belongs to the ABC transporter superfamily
M164_RS12080	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
M164_RS12115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M164_RS12120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M164_RS12120	COG1648	precorrin-2 dehydrogenase activity
M164_RS12125	COG2897	thiosulfate sulfurtransferase activity
M164_RS12155	COG0667	Aldo Keto reductase
M164_RS12170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M164_RS12170	COG3608	succinylglutamate desuccinylase aspartoacylase
M164_RS12180	COG1960	acyl-CoA dehydrogenase activity
M164_RS12185	COG0318	PFAM AMP-dependent synthetase and ligase
M164_RS12200	COG1250	3-hydroxyacyl-CoA dehydrogenase
M164_RS12210	COG0281	malic enzyme
M164_RS12235	COG1584	GPR1 FUN34 yaaH family protein
M164_RS12240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M164_RS12275	COG0477	Major facilitator Superfamily
M164_RS12280	COG3842	ATPase activity
M164_RS12285	COG0395	ABC-type sugar transport system, permease component
M164_RS12310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M164_RS12350	COG3383	formate dehydrogenase (NAD+) activity
M164_RS12360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M164_RS12365	COG3848	Pyruvate phosphate dikinase
M164_RS12365	COG0574	Belongs to the PEP-utilizing enzyme family
M164_RS12375	COG0644	oxidoreductase
M164_RS12380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M164_RS12385	COG1013	pyruvate-flavodoxin oxidoreductase activity
M164_RS12390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M164_RS12390	COG0674	pyruvate-flavodoxin oxidoreductase activity
M164_RS12415	COG0318	PFAM AMP-dependent synthetase and ligase
M164_RS12470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M164_RS12495	COG1063	alcohol dehydrogenase
M164_RS12520	COG0243	molybdopterin cofactor binding
M164_RS12525	COG0437	4 iron, 4 sulfur cluster binding
M164_RS12590	COG0668	transmembrane transport
M164_RS12595	COG0586	Pfam SNARE associated Golgi protein
M164_RS12610	COG0022	dehydrogenase e1 component
M164_RS12630	COG0656	L-ascorbic acid biosynthetic process
M164_RS12635	COG0589	response to stress
M164_RS12645	COG0644	oxidoreductase
M164_RS12660	COG0028	Belongs to the TPP enzyme family
M164_RS12675	COG0402	S-adenosylhomocysteine deaminase activity
M164_RS12695	COG0492	ferredoxin-NADP+ reductase activity
M164_RS12705	COG2086	electron transfer activity
M164_RS12715	COG1960	acyl-CoA dehydrogenase activity
M164_RS12730	COG0437	4 iron, 4 sulfur cluster binding
M164_RS12735	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M164_RS12740	COG1144	Oxidoreductase
M164_RS12745	COG0674	pyruvate-flavodoxin oxidoreductase activity
M164_RS12750	COG1013	pyruvate-flavodoxin oxidoreductase activity
M164_RS12755	COG0438	transferase activity, transferring glycosyl groups
M164_RS12760	COG3387	PFAM Glycoside hydrolase 15-related
M164_RS12815	COG3387	PFAM Glycoside hydrolase 15-related
M164_RS12825	COG0517	IMP dehydrogenase activity
M164_RS12835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M164_RS12895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M164_RS12905	COG2814	Major facilitator Superfamily
M164_RS12920	COG0395	ABC-type sugar transport system, permease component
M164_RS12925	COG3842	ATPase activity
M164_RS12955	COG0813	purine-nucleoside phosphorylase activity
M164_RS12960	COG3386	PFAM SMP-30 Gluconolaconase
M164_RS12965	COG2814	Major facilitator Superfamily
M164_RS13010	COG4274	PFAM GYD family protein
M164_RS13020	COG1506	peptidase
M164_RS13020	COG4946	Tricorn protease homolog
M164_RS13020	COG0823	Involved in the tonB-independent uptake of proteins
M164_RS13035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M164_RS13120	COG4608	Belongs to the ABC transporter superfamily
M164_RS13125	COG0444	Belongs to the ABC transporter superfamily
M164_RS13140	COG0601	transmembrane transport
M164_RS13155	COG4948	Mandelate Racemase Muconate Lactonizing
M164_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
M164_RS13215	COG2217	Heavy metal translocating P-type atpase
M164_RS13225	COG4555	ABC transporter
M164_RS13250	COG1592	Rubrerythrin
M164_RS13285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M164_RS13335	COG0183	Belongs to the thiolase family
M164_RS13345	COG1024	Enoyl-CoA hydratase
M164_RS13370	COG0601	transmembrane transport
M164_RS13375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M164_RS13380	COG0444	Belongs to the ABC transporter superfamily
M164_RS13385	COG4608	Belongs to the ABC transporter superfamily
M164_RS13395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M164_RS13400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M164_RS13415	COG0438	transferase activity, transferring glycosyl groups
M164_RS13435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M164_RS13460	COG1131	(ABC) transporter
M164_RS13465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M164_RS13470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M164_RS13475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M164_RS13495	COG0149	triose-phosphate isomerase activity
M164_RS13510	COG0372	Belongs to the citrate synthase family
M164_RS13515	COG0517	IMP dehydrogenase activity
M164_RS13515	COG0516	GMP reductase activity
M164_RS13520	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M164_RS13525	COG2079	MmgE PrpD family protein
M164_RS13530	COG0039	L-malate dehydrogenase activity
M164_RS13535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M164_RS13585	COG1489	DNA binding
M164_RS13615	COG0778	Nitroreductase
M164_RS13620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M164_RS13730	COG0308	aminopeptidase N
M164_RS13745	COG0561	phosphatase activity
M164_RS13755	COG1011	Hydrolase
M164_RS13770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M164_RS13805	COG0494	nUDIX hydrolase
M164_RS13815	COG3253	May function as heme-dependent peroxidase
M164_RS13830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M164_RS13860	COG2226	methyltransferase
M164_RS13885	COG0538	isocitrate dehydrogenase activity
M164_RS14335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate