locus-tag	class	description
SIRE_RS00020	COG2154	pterin-4-alpha-carbinolamine dehydratase
SIRE_RS00100	COG1331	Highly conserved protein containing a thioredoxin domain
SIRE_RS00110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SIRE_RS00120	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SIRE_RS00145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SIRE_RS00160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIRE_RS00170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SIRE_RS00175	COG2814	Major facilitator Superfamily
SIRE_RS00185	COG0492	ferredoxin-NADP+ reductase activity
SIRE_RS00255	COG0588	phosphoglycerate mutase activity
SIRE_RS00275	COG1957	nucleoside hydrolase
SIRE_RS00325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SIRE_RS00325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SIRE_RS00330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SIRE_RS00335	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
SIRE_RS00355	COG0596	Alpha beta hydrolase
SIRE_RS00370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SIRE_RS00410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIRE_RS00415	COG1573	uracil-dna glycosylase
SIRE_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
SIRE_RS00445	COG0215	cysteine-tRNA ligase activity
SIRE_RS00450	COG2222	sugar isomerase
SIRE_RS00460	COG0446	pyridine nucleotide-disulphide oxidoreductase
SIRE_RS00470	COG0433	COG0433 Predicted ATPase
SIRE_RS00480	COG1607	acyl-coa hydrolase
SIRE_RS00490	COG1028	Short-chain dehydrogenase reductase Sdr
SIRE_RS00495	COG0708	Exodeoxyribonuclease III
SIRE_RS00500	COG0515	serine threonine protein kinase
SIRE_RS00500	COG2815	serine threonine protein kinase
SIRE_RS00535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SIRE_RS00535	COG1648	precorrin-2 dehydrogenase activity
SIRE_RS00545	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SIRE_RS00580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIRE_RS00590	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
SIRE_RS00700	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SIRE_RS00705	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SIRE_RS00720	COG0189	ligase activity
SIRE_RS00760	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SIRE_RS00775	COG0647	UMP catabolic process
SIRE_RS00780	COG1053	succinate dehydrogenase
SIRE_RS00800	COG2304	oxidoreductase activity
SIRE_RS00805	COG0714	Associated with various cellular activities
SIRE_RS00830	COG0083	homoserine kinase activity
SIRE_RS00835	COG0626	cystathionine gamma-synthase activity
SIRE_RS00875	COG0183	Belongs to the thiolase family
SIRE_RS00880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SIRE_RS00920	COG1215	transferase activity, transferring glycosyl groups
SIRE_RS00925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SIRE_RS00935	COG0351	phosphomethylpyrimidine kinase
SIRE_RS00940	COG0314	molybdopterin synthase activity
SIRE_RS00965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SIRE_RS00975	COG1131	(ABC) transporter
SIRE_RS01000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SIRE_RS01005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SIRE_RS01035	COG0720	synthase
SIRE_RS01050	COG0492	ferredoxin-NADP+ reductase activity
SIRE_RS01060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIRE_RS01080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SIRE_RS01080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SIRE_RS01090	COG0071	Belongs to the small heat shock protein (HSP20) family
SIRE_RS01150	COG0402	S-adenosylhomocysteine deaminase activity
SIRE_RS01175	COG0430	RNA-3'-phosphate cyclase activity
SIRE_RS01185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SIRE_RS01190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SIRE_RS01195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIRE_RS01205	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SIRE_RS01215	COG1515	deoxyribonuclease V activity
SIRE_RS01220	COG1335	isochorismatase
SIRE_RS01255	COG4581	dead DEAH box helicase
SIRE_RS01265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SIRE_RS01275	COG0439	Biotin carboxylase
SIRE_RS01295	COG1116	anion transmembrane transporter activity
SIRE_RS01305	COG0066	3-isopropylmalate dehydratase activity
SIRE_RS01310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SIRE_RS01315	COG0415	Belongs to the DNA photolyase family
SIRE_RS01350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SIRE_RS01395	COG0045	succinate-CoA ligase (ADP-forming) activity
SIRE_RS01410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SIRE_RS01415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SIRE_RS01465	COG0657	acetylesterase activity
SIRE_RS01470	COG1063	alcohol dehydrogenase
SIRE_RS01475	COG0183	Belongs to the thiolase family
SIRE_RS01480	COG1960	acyl-CoA dehydrogenase activity
SIRE_RS01485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SIRE_RS01490	COG1028	Short-chain dehydrogenase reductase Sdr
SIRE_RS01495	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SIRE_RS01535	COG0318	PFAM AMP-dependent synthetase and ligase
SIRE_RS01540	COG1960	acyl-CoA dehydrogenase activity
SIRE_RS01545	COG1024	Enoyl-CoA hydratase
SIRE_RS01550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIRE_RS01555	COG2814	Major facilitator Superfamily
SIRE_RS01555	COG0477	Major facilitator Superfamily
SIRE_RS01590	COG0318	PFAM AMP-dependent synthetase and ligase
SIRE_RS01600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SIRE_RS01605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SIRE_RS01690	COG0432	Pfam Uncharacterised protein family UPF0047
SIRE_RS01695	COG1305	Transglutaminase-like
SIRE_RS01710	COG1522	sequence-specific DNA binding
SIRE_RS01715	COG1013	pyruvate-flavodoxin oxidoreductase activity
SIRE_RS01720	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIRE_RS01735	COG1620	l-lactate permease
SIRE_RS01755	COG0450	alkyl hydroperoxide reductase
SIRE_RS01800	COG3573	Dehydrogenase
SIRE_RS01820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SIRE_RS01825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SIRE_RS01835	COG2062	phosphohistidine phosphatase, SixA
SIRE_RS01845	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIRE_RS01890	COG0277	FAD linked oxidase domain protein
SIRE_RS01905	COG1012	belongs to the aldehyde dehydrogenase family
SIRE_RS01955	COG3350	monooxygenase activity
SIRE_RS01980	COG2151	metal-sulfur cluster biosynthetic enzyme
SIRE_RS01985	COG0028	Belongs to the TPP enzyme family
SIRE_RS02000	COG1741	Belongs to the pirin family
SIRE_RS02015	COG1024	Enoyl-CoA hydratase
SIRE_RS02025	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SIRE_RS02075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SIRE_RS02085	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SIRE_RS02085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SIRE_RS02090	COG0675	Transposase, IS605 OrfB family
SIRE_RS02100	COG1017	nitric oxide dioxygenase activity
SIRE_RS02135	COG4608	Belongs to the ABC transporter superfamily
SIRE_RS02140	COG0444	Belongs to the ABC transporter superfamily
SIRE_RS02150	COG0601	transmembrane transport
SIRE_RS02165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SIRE_RS02180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SIRE_RS02185	COG1131	(ABC) transporter
SIRE_RS02210	COG2721	sulfolactate sulfo-lyase activity
SIRE_RS02215	COG2721	sulfolactate sulfo-lyase activity
SIRE_RS02230	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SIRE_RS02235	COG1802	Transcriptional regulator
SIRE_RS02240	COG2301	Belongs to the HpcH HpaI aldolase family
SIRE_RS02245	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SIRE_RS02245	COG2050	protein possibly involved in aromatic compounds catabolism
SIRE_RS02275	COG2181	nitrate reductase activity
SIRE_RS02280	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SIRE_RS02285	COG1140	nitrate reductase beta subunit
SIRE_RS02305	COG0318	PFAM AMP-dependent synthetase and ligase
SIRE_RS02415	COG2084	Dehydrogenase
SIRE_RS02470	COG0412	Dienelactone hydrolase
SIRE_RS02500	COG1523	belongs to the glycosyl hydrolase 13 family
SIRE_RS02520	COG4946	Tricorn protease homolog
SIRE_RS02520	COG0793	Belongs to the peptidase S41A family
SIRE_RS02525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SIRE_RS02590	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SIRE_RS02605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SIRE_RS02630	COG1960	acyl-CoA dehydrogenase activity
SIRE_RS02635	COG0318	PFAM AMP-dependent synthetase and ligase
SIRE_RS02650	COG2814	Major facilitator Superfamily
SIRE_RS02720	COG0243	molybdopterin cofactor binding
SIRE_RS02765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIRE_RS02840	COG1953	Uracil, thiamine, allantoin
SIRE_RS02870	COG2814	Major facilitator Superfamily
SIRE_RS02875	COG4948	Mandelate Racemase Muconate Lactonizing
SIRE_RS02910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIRE_RS02915	COG0477	Major facilitator Superfamily
SIRE_RS02925	COG1028	Short-chain dehydrogenase reductase Sdr
SIRE_RS03005	COG1131	(ABC) transporter
SIRE_RS03020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SIRE_RS03225	COG0675	Transposase, IS605 OrfB family
SIRE_RS03235	COG0589	response to stress
SIRE_RS03250	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SIRE_RS03260	COG0501	Belongs to the peptidase M48B family
SIRE_RS03305	COG2226	methyltransferase
SIRE_RS03325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SIRE_RS03325	COG0045	succinate-CoA ligase (ADP-forming) activity
SIRE_RS03325	COG1042	CoA-binding domain protein
SIRE_RS03360	COG0425	Belongs to the sulfur carrier protein TusA family
SIRE_RS03370	COG1024	Enoyl-CoA hydratase
SIRE_RS03430	COG1011	Hydrolase
SIRE_RS03480	COG0477	Major facilitator Superfamily
SIRE_RS03490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIRE_RS03495	COG1953	Uracil, thiamine, allantoin
SIRE_RS03500	COG0531	amino acid
SIRE_RS03505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SIRE_RS03520	COG0675	Transposase, IS605 OrfB family
SIRE_RS03545	COG0477	Major facilitator Superfamily
SIRE_RS03590	COG2368	4-hydroxyphenylacetate
SIRE_RS03600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SIRE_RS03605	COG2271	Major facilitator Superfamily
SIRE_RS03615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIRE_RS03620	COG1960	acyl-CoA dehydrogenase activity
SIRE_RS03665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIRE_RS03670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SIRE_RS03705	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SIRE_RS03715	COG0675	Transposase, IS605 OrfB family
SIRE_RS03730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SIRE_RS03735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIRE_RS03745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SIRE_RS03750	COG2224	Isocitrate lyase
SIRE_RS03765	COG0598	Magnesium transport protein CorA
SIRE_RS03795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SIRE_RS03815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SIRE_RS03890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SIRE_RS03915	COG0675	Transposase, IS605 OrfB family
SIRE_RS03935	COG1373	ATPase (AAA superfamily
SIRE_RS03985	COG1473	amidohydrolase
SIRE_RS04040	COG1131	(ABC) transporter
SIRE_RS04110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SIRE_RS04190	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SIRE_RS04265	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SIRE_RS04300	COG1215	transferase activity, transferring glycosyl groups
SIRE_RS04310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SIRE_RS04320	COG0438	transferase activity, transferring glycosyl groups
SIRE_RS04355	COG1216	Glycosyl transferase, family 2
SIRE_RS04355	COG1442	glycosyl transferase family 8
SIRE_RS04380	COG0438	transferase activity, transferring glycosyl groups
SIRE_RS04415	COG3119	arylsulfatase activity
SIRE_RS04420	COG1215	transferase activity, transferring glycosyl groups
SIRE_RS04435	COG0175	sulfate reduction
SIRE_RS04445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SIRE_RS04460	COG0675	Transposase, IS605 OrfB family
SIRE_RS04590	COG0535	radical SAM domain protein
SIRE_RS04595	COG0535	radical SAM domain protein
SIRE_RS04600	COG1012	belongs to the aldehyde dehydrogenase family
SIRE_RS04715	COG2271	Major facilitator Superfamily
SIRE_RS04765	COG2814	Major facilitator Superfamily
SIRE_RS04805	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SIRE_RS04830	COG1960	acyl-CoA dehydrogenase activity
SIRE_RS04870	COG0477	Major facilitator Superfamily
SIRE_RS04875	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SIRE_RS04880	COG1131	(ABC) transporter
SIRE_RS04905	COG0475	glutathione-regulated potassium exporter activity
SIRE_RS04920	COG2048	Heterodisulfide reductase, subunit B
SIRE_RS04950	COG0425	Belongs to the sulfur carrier protein TusA family
SIRE_RS04955	COG2210	Belongs to the sulfur carrier protein TusA family
SIRE_RS04965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIRE_RS05000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SIRE_RS05010	COG0095	Lipoate-protein ligase
SIRE_RS05015	COG1832	CoA-binding protein
SIRE_RS05045	COG0509	glycine decarboxylation via glycine cleavage system
SIRE_RS05095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SIRE_RS05140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SIRE_RS05150	COG1846	Transcriptional regulator
SIRE_RS05155	COG0577	efflux transmembrane transporter activity
SIRE_RS05155	COG1136	(ABC) transporter
SIRE_RS05165	COG1136	(ABC) transporter
SIRE_RS05170	COG0114	fumarate hydratase activity
SIRE_RS05180	COG0517	IMP dehydrogenase activity
SIRE_RS05185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SIRE_RS05185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SIRE_RS05190	COG0531	amino acid
SIRE_RS05195	COG0693	protein deglycase activity
SIRE_RS05205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SIRE_RS05210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SIRE_RS05230	COG0509	glycine decarboxylation via glycine cleavage system
SIRE_RS05270	COG0004	ammonium transporteR
SIRE_RS05290	COG1185	polyribonucleotide nucleotidyltransferase activity
SIRE_RS05335	COG1234	tRNA 3'-trailer cleavage
SIRE_RS05350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SIRE_RS05385	COG0488	(ABC) transporter
SIRE_RS05400	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SIRE_RS05405	COG0725	ABC transporter, periplasmic molybdate-binding protein
SIRE_RS05410	COG0300	oxidoreductase activity
SIRE_RS05415	COG3383	formate dehydrogenase (NAD+) activity
SIRE_RS05440	COG0651	ATP synthesis coupled electron transport
SIRE_RS05445	COG0649	NAD binding
SIRE_RS05450	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIRE_RS05455	COG0651	ATP synthesis coupled electron transport
SIRE_RS05465	COG2897	thiosulfate sulfurtransferase activity
SIRE_RS05470	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SIRE_RS05490	COG0028	Belongs to the TPP enzyme family
SIRE_RS05495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIRE_RS05505	COG0395	ABC-type sugar transport system, permease component
SIRE_RS05520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SIRE_RS05525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SIRE_RS05530	COG0157	Belongs to the NadC ModD family
SIRE_RS05560	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SIRE_RS05570	COG0297	glycogen (starch) synthase activity
SIRE_RS05580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SIRE_RS05595	COG0469	pyruvate kinase activity
SIRE_RS05610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SIRE_RS05620	COG0528	UMP kinase activity
SIRE_RS05630	COG1028	Short-chain dehydrogenase reductase Sdr
SIRE_RS05645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SIRE_RS05650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SIRE_RS05660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SIRE_RS05690	COG1110	DNA topoisomerase II activity
SIRE_RS05730	COG0154	amidase activity
SIRE_RS05745	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SIRE_RS05745	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SIRE_RS05800	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
SIRE_RS05830	COG0252	asparaginase activity
SIRE_RS05835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SIRE_RS05865	COG1372	Participates in initiation and elongation during chromosome replication
SIRE_RS05865	COG0719	Fe-S assembly protein
SIRE_RS05870	COG0719	Fe-S assembly protein
SIRE_RS05875	COG0396	ATPase activity
SIRE_RS05895	COG0509	glycine decarboxylation via glycine cleavage system
SIRE_RS05900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SIRE_RS05910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SIRE_RS05930	COG0148	phosphopyruvate hydratase activity
SIRE_RS05950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIRE_RS05955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SIRE_RS05970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SIRE_RS06000	COG0644	oxidoreductase
SIRE_RS06005	COG0525	valine-tRNA ligase activity
SIRE_RS06010	COG0436	Aminotransferase
SIRE_RS06015	COG0134	indole-3-glycerol-phosphate synthase activity
SIRE_RS06020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SIRE_RS06020	COG0512	Glutamine amidotransferase of anthranilate synthase
SIRE_RS06025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SIRE_RS06030	COG0135	phosphoribosylanthranilate isomerase activity
SIRE_RS06040	COG0159	tryptophan synthase activity
SIRE_RS06045	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SIRE_RS06050	COG1254	Belongs to the acylphosphatase family
SIRE_RS06055	COG1260	myo-inositol-1-phosphate synthase
SIRE_RS06060	COG0574	Belongs to the PEP-utilizing enzyme family
SIRE_RS06060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SIRE_RS06080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SIRE_RS06085	COG0460	homoserine dehydrogenase
SIRE_RS06085	COG0527	aspartate kinase activity
SIRE_RS06105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SIRE_RS06140	COG0459	protein refolding
SIRE_RS06185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SIRE_RS06245	COG0315	cyclic pyranopterin monophosphate synthase activity
SIRE_RS06250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SIRE_RS06255	COG2255	four-way junction helicase activity
SIRE_RS06260	COG1881	PFAM PEBP family protein
SIRE_RS06265	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SIRE_RS06275	COG1063	alcohol dehydrogenase
SIRE_RS06330	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SIRE_RS06340	COG1047	Peptidyl-prolyl cis-trans
SIRE_RS06355	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SIRE_RS06370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SIRE_RS06410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SIRE_RS06415	COG2264	protein methyltransferase activity
SIRE_RS06420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SIRE_RS06430	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SIRE_RS06475	COG1185	polyribonucleotide nucleotidyltransferase activity
SIRE_RS06500	COG0322	excinuclease ABC activity
SIRE_RS06505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SIRE_RS06525	COG0473	3-isopropylmalate dehydrogenase activity
SIRE_RS06530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SIRE_RS06540	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SIRE_RS06555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SIRE_RS06560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SIRE_RS06565	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SIRE_RS06570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SIRE_RS06575	COG0255	Belongs to the universal ribosomal protein uL29 family
SIRE_RS06585	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SIRE_RS06590	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SIRE_RS06595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SIRE_RS06605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SIRE_RS06615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SIRE_RS06620	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SIRE_RS06640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SIRE_RS06675	COG0563	adenylate kinase activity
SIRE_RS06750	COG0577	efflux transmembrane transporter activity
SIRE_RS06750	COG1136	(ABC) transporter
SIRE_RS06760	COG0069	glutamate synthase activity
SIRE_RS06765	COG0067	glutamate synthase
SIRE_RS06780	COG0402	S-adenosylhomocysteine deaminase activity
SIRE_RS06795	COG0303	'Molybdopterin
SIRE_RS06810	COG2226	methyltransferase
SIRE_RS06830	COG1321	iron dependent repressor
SIRE_RS06840	COG2379	hydroxypyruvate reductase
SIRE_RS06845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIRE_RS06850	COG0009	L-threonylcarbamoyladenylate synthase
SIRE_RS06865	COG0312	modulator of DNA gyrase
SIRE_RS06870	COG0312	modulator of DNA gyrase
SIRE_RS06875	COG0864	Transcriptional regulator
SIRE_RS06885	COG0460	homoserine dehydrogenase
SIRE_RS06900	COG1024	Enoyl-CoA hydratase
SIRE_RS06940	COG1250	3-hydroxyacyl-CoA dehydrogenase
SIRE_RS06950	COG0189	ligase activity
SIRE_RS06960	COG0505	Belongs to the CarA family
SIRE_RS06965	COG0165	Argininosuccinate lyase
SIRE_RS06970	COG0137	argininosuccinate synthase activity
SIRE_RS06985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SIRE_RS06990	COG0151	Belongs to the GarS family
SIRE_RS06995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SIRE_RS07000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SIRE_RS07010	COG0047	phosphoribosylformylglycinamidine synthase activity
SIRE_RS07020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SIRE_RS07025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIRE_RS07025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIRE_RS07030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SIRE_RS07035	COG0602	queuosine metabolic process
SIRE_RS07070	COG0284	orotidine-5'-phosphate decarboxylase activity
SIRE_RS07075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SIRE_RS07080	COG0540	Belongs to the ATCase OTCase family
SIRE_RS07085	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
SIRE_RS07100	COG0167	dihydroorotate dehydrogenase activity
SIRE_RS07115	COG2095	MarC family integral membrane protein
SIRE_RS07120	COG1522	sequence-specific DNA binding
SIRE_RS07135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SIRE_RS07140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SIRE_RS07145	COG2151	metal-sulfur cluster biosynthetic enzyme
SIRE_RS07155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SIRE_RS07160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SIRE_RS07160	COG0140	phosphoribosyl-ATP diphosphatase activity
SIRE_RS07165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SIRE_RS07170	COG0107	imidazoleglycerol-phosphate synthase activity
SIRE_RS07175	COG0131	Imidazoleglycerol-phosphate dehydratase
SIRE_RS07180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SIRE_RS07185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SIRE_RS07190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SIRE_RS07200	COG0495	leucyl-tRNA aminoacylation
SIRE_RS07205	COG2096	Adenosyltransferase
SIRE_RS07210	COG0037	tRNA processing
SIRE_RS07220	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SIRE_RS07245	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SIRE_RS07255	COG0028	Belongs to the TPP enzyme family
SIRE_RS07265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SIRE_RS07280	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SIRE_RS07285	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SIRE_RS07295	COG0442	prolyl-tRNA aminoacylation
SIRE_RS07310	COG1394	ATPase activity, coupled to movement of substances
SIRE_RS07320	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SIRE_RS07340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIRE_RS07370	COG0417	DNA replication proofreading
SIRE_RS07385	COG0668	transmembrane transport
SIRE_RS07395	COG0126	phosphoglycerate kinase activity
SIRE_RS07405	COG0589	response to stress
SIRE_RS07410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SIRE_RS07430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SIRE_RS07435	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SIRE_RS07605	COG0495	leucyl-tRNA aminoacylation
SIRE_RS07655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SIRE_RS07680	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SIRE_RS07685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SIRE_RS07690	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SIRE_RS07705	COG0805	protein transport
SIRE_RS07715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SIRE_RS07740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SIRE_RS07750	COG0556	nucleotide-excision repair
SIRE_RS07755	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SIRE_RS07765	COG3276	selenocysteine insertion sequence binding
SIRE_RS07785	COG0351	phosphomethylpyrimidine kinase
SIRE_RS07785	COG1992	Thiamine-phosphate synthase
SIRE_RS07815	COG0489	protein tyrosine kinase activity
SIRE_RS07835	COG1280	lysine exporter protein (LysE YggA)
SIRE_RS07865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SIRE_RS07915	COG0423	glycine-tRNA ligase activity
SIRE_RS07945	COG0163	prenyltransferase activity
SIRE_RS07950	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SIRE_RS07970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SIRE_RS07975	COG0667	Aldo Keto reductase
SIRE_RS08020	COG1110	DNA topoisomerase II activity
SIRE_RS08025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIRE_RS08030	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SIRE_RS08075	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SIRE_RS08090	COG1797	cobyrinic acid a,c-diamide synthase activity
SIRE_RS08110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SIRE_RS08120	COG0402	S-adenosylhomocysteine deaminase activity
SIRE_RS08140	COG1201	RNA secondary structure unwinding
SIRE_RS08155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SIRE_RS08160	COG2813	Specifically methylates the guanine in position
SIRE_RS08170	COG1444	tRNA N-acetyltransferase activity
SIRE_RS08215	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SIRE_RS08220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SIRE_RS08230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SIRE_RS08255	COG0475	glutathione-regulated potassium exporter activity
SIRE_RS08265	COG0535	radical SAM domain protein
SIRE_RS08270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SIRE_RS08275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SIRE_RS08275	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SIRE_RS08285	COG0318	PFAM AMP-dependent synthetase and ligase
SIRE_RS08290	COG3118	belongs to the thioredoxin family
SIRE_RS08295	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SIRE_RS08310	COG0302	gtp cyclohydrolase
SIRE_RS08320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SIRE_RS08335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SIRE_RS08400	COG0552	protein localization to endoplasmic reticulum
SIRE_RS08415	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SIRE_RS08435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SIRE_RS08470	COG1260	myo-inositol-1-phosphate synthase
SIRE_RS08475	COG1007	ATP synthesis coupled electron transport
SIRE_RS08480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SIRE_RS08485	COG0713	ATP synthesis coupled electron transport
SIRE_RS08495	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIRE_RS08500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SIRE_RS08505	COG0649	NAD binding
SIRE_RS08510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SIRE_RS08520	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SIRE_RS08540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SIRE_RS08545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SIRE_RS08585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SIRE_RS08595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SIRE_RS08600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SIRE_RS08605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SIRE_RS08610	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SIRE_RS08615	COG0077	Prephenate dehydratase
SIRE_RS08615	COG1605	Chorismate mutase
SIRE_RS08620	COG3958	Transketolase
SIRE_RS08625	COG3959	Transketolase, thiamine diphosphate binding domain
SIRE_RS08630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SIRE_RS08650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SIRE_RS08660	COG1185	polyribonucleotide nucleotidyltransferase activity
SIRE_RS08685	COG0477	Major facilitator Superfamily
SIRE_RS08695	COG1121	(ABC) transporter
SIRE_RS08700	COG1980	fructose-bisphosphate aldolase activity
SIRE_RS08725	COG0459	protein refolding
SIRE_RS08740	COG0124	histidyl-tRNA synthetase
SIRE_RS08775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIRE_RS08785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SIRE_RS08825	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SIRE_RS08860	COG1056	cytidyltransferase-related domain
SIRE_RS08860	COG1051	belongs to the nudix hydrolase family
SIRE_RS08875	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SIRE_RS08875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SIRE_RS08900	COG1605	Chorismate mutase
SIRE_RS08900	COG0077	Prephenate dehydratase
SIRE_RS08915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SIRE_RS08930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SIRE_RS08945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SIRE_RS08960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SIRE_RS08965	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SIRE_RS08980	COG0105	UTP biosynthetic process
SIRE_RS08995	COG0085	RNA polymerase activity
SIRE_RS09000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SIRE_RS09005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SIRE_RS09030	COG0049	tRNA binding
SIRE_RS09035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SIRE_RS09040	COG0051	transcription antitermination factor activity, RNA binding
SIRE_RS09080	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SIRE_RS09085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SIRE_RS09160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SIRE_RS09180	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SIRE_RS09185	COG0504	CTP synthase activity
SIRE_RS09200	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SIRE_RS09230	COG2078	PFAM AMMECR1 domain protein
SIRE_RS09245	COG0717	Belongs to the dCTP deaminase family
SIRE_RS09250	COG1793	dna ligase
SIRE_RS09255	COG1793	dna ligase
SIRE_RS09255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SIRE_RS09260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SIRE_RS09285	COG0181	hydroxymethylbilane synthase activity
SIRE_RS09290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SIRE_RS09295	COG0113	porphobilinogen synthase activity
SIRE_RS09300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SIRE_RS09320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIRE_RS09340	COG0585	pseudouridine synthase activity
SIRE_RS09345	COG0017	Asparaginyl-tRNA synthetase
SIRE_RS09360	COG0028	Belongs to the TPP enzyme family
SIRE_RS09375	COG1122	ATPase activity
SIRE_RS09405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SIRE_RS09410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIRE_RS09415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SIRE_RS09420	COG0189	ligase activity
SIRE_RS09435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SIRE_RS09440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SIRE_RS09455	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SIRE_RS09500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SIRE_RS09535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SIRE_RS09540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SIRE_RS09590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SIRE_RS09605	COG1201	RNA secondary structure unwinding
SIRE_RS09610	COG0517	IMP dehydrogenase activity
SIRE_RS09610	COG0617	tRNA 3'-terminal CCA addition
SIRE_RS09610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SIRE_RS09635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SIRE_RS09640	COG1058	Belongs to the CinA family
SIRE_RS09640	COG1546	Belongs to the CinA family
SIRE_RS09645	COG2267	carboxylic ester hydrolase activity
SIRE_RS09660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SIRE_RS09685	COG1078	dGTPase activity
SIRE_RS09690	COG0561	phosphatase activity
SIRE_RS09695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SIRE_RS09710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SIRE_RS09740	COG1214	PFAM Peptidase M22, glycoprotease
SIRE_RS09740	COG0456	acetyltransferase
SIRE_RS09755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SIRE_RS09770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SIRE_RS09775	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SIRE_RS09780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SIRE_RS09790	COG0200	Binds to the 23S rRNA
SIRE_RS09795	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SIRE_RS09800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SIRE_RS09810	COG0052	Belongs to the universal ribosomal protein uS2 family
SIRE_RS09815	COG1355	regulation of microtubule-based process
SIRE_RS09830	COG1304	FMN binding
SIRE_RS09925	COG1131	(ABC) transporter
SIRE_RS09955	COG0084	hydrolase, TatD family'
SIRE_RS09970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SIRE_RS10010	COG1192	Involved in chromosome partitioning
SIRE_RS10030	COG0617	tRNA 3'-terminal CCA addition
SIRE_RS10030	COG3620	sequence-specific DNA binding
SIRE_RS10030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SIRE_RS10040	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SIRE_RS10085	COG1201	RNA secondary structure unwinding
SIRE_RS10095	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SIRE_RS10120	COG2860	membrane
SIRE_RS10135	COG0123	including yeast histone deacetylase and acetoin utilization protein
SIRE_RS10155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SIRE_RS10160	COG0352	thiamine-phosphate diphosphorylase activity
SIRE_RS10160	COG0351	phosphomethylpyrimidine kinase
SIRE_RS10170	COG1215	transferase activity, transferring glycosyl groups
SIRE_RS10220	COG0463	Glycosyl transferase, family 2
SIRE_RS10240	COG1063	alcohol dehydrogenase
SIRE_RS10260	COG0519	Catalyzes the synthesis of GMP from XMP
SIRE_RS10260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SIRE_RS10265	COG0501	Belongs to the peptidase M48B family
SIRE_RS10270	COG0517	IMP dehydrogenase activity
SIRE_RS10270	COG0516	GMP reductase activity
SIRE_RS10280	COG1830	Aldolase
SIRE_RS10305	COG0405	Gamma-glutamyltransferase
SIRE_RS10320	COG1444	tRNA N-acetyltransferase activity
SIRE_RS10335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SIRE_RS10345	COG0656	L-ascorbic acid biosynthetic process
SIRE_RS10360	COG0251	oxidation-reduction process
SIRE_RS10365	COG0617	tRNA 3'-terminal CCA addition
SIRE_RS10365	COG0517	IMP dehydrogenase activity
SIRE_RS10365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SIRE_RS10370	COG1063	alcohol dehydrogenase
SIRE_RS10375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIRE_RS10385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SIRE_RS10395	COG4948	Mandelate Racemase Muconate Lactonizing
SIRE_RS10400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIRE_RS10405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SIRE_RS10410	COG1012	belongs to the aldehyde dehydrogenase family
SIRE_RS10420	COG0243	molybdopterin cofactor binding
SIRE_RS10465	COG0833	amino acid
SIRE_RS10470	COG0589	response to stress
SIRE_RS10485	COG2814	Major facilitator Superfamily
SIRE_RS10570	COG1733	regulation of RNA biosynthetic process
SIRE_RS10580	COG0516	GMP reductase activity
SIRE_RS10580	COG0517	IMP dehydrogenase activity
SIRE_RS10585	COG1720	tRNA m6t6A37 methyltransferase activity
SIRE_RS10630	COG0277	FAD linked oxidase domain protein
SIRE_RS10635	COG0247	lactate metabolic process
SIRE_RS10640	COG0095	Lipoate-protein ligase
SIRE_RS10645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SIRE_RS10660	COG0655	NAD(P)H dehydrogenase (quinone) activity
SIRE_RS10685	COG0477	Major facilitator Superfamily
SIRE_RS10715	COG2271	Major facilitator Superfamily
SIRE_RS10745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SIRE_RS10765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SIRE_RS10775	COG1139	Iron-sulfur cluster binding protein
SIRE_RS10780	COG2814	Major facilitator Superfamily
SIRE_RS10800	COG4948	Mandelate Racemase Muconate Lactonizing
SIRE_RS10810	COG0477	Major facilitator Superfamily
SIRE_RS10815	COG2271	Major facilitator Superfamily
SIRE_RS10820	COG0179	Fumarylacetoacetate (FAA) hydrolase
SIRE_RS10830	COG2267	carboxylic ester hydrolase activity
SIRE_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
SIRE_RS10870	COG0805	protein transport
SIRE_RS10885	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SIRE_RS10935	COG1134	teichoic acid transport
SIRE_RS10975	COG0425	Belongs to the sulfur carrier protein TusA family
SIRE_RS10995	COG1136	(ABC) transporter
SIRE_RS11060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIRE_RS11070	COG3842	ATPase activity
SIRE_RS11075	COG0395	ABC-type sugar transport system, permease component
SIRE_RS11090	COG0318	PFAM AMP-dependent synthetase and ligase
SIRE_RS11125	COG0667	Aldo Keto reductase
SIRE_RS11150	COG0673	inositol 2-dehydrogenase activity
SIRE_RS11160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SIRE_RS11165	COG0444	Belongs to the ABC transporter superfamily
SIRE_RS11170	COG4608	Belongs to the ABC transporter superfamily
SIRE_RS11185	COG3386	PFAM SMP-30 Gluconolaconase
SIRE_RS11200	COG3250	beta-galactosidase activity
SIRE_RS11205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIRE_RS11210	COG1472	Belongs to the glycosyl hydrolase 3 family
SIRE_RS11260	COG3408	Glycogen debranching enzyme
SIRE_RS11285	COG1501	Belongs to the glycosyl hydrolase 31 family
SIRE_RS11295	COG2723	6-phospho-beta-galactosidase activity
SIRE_RS11315	COG0667	Aldo Keto reductase
SIRE_RS11325	COG1132	(ABC) transporter
SIRE_RS11345	COG0673	inositol 2-dehydrogenase activity
SIRE_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
SIRE_RS11390	COG0459	protein refolding
SIRE_RS11395	COG4948	Mandelate Racemase Muconate Lactonizing
SIRE_RS11400	COG1250	3-hydroxyacyl-CoA dehydrogenase
SIRE_RS11405	COG1914	H( )-stimulated, divalent metal cation uptake system
SIRE_RS11480	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SIRE_RS11500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SIRE_RS11515	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SIRE_RS11515	COG2857	Cytochrome c1
SIRE_RS11575	COG0601	transmembrane transport
SIRE_RS11580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SIRE_RS11585	COG0444	Belongs to the ABC transporter superfamily
SIRE_RS11590	COG4608	Belongs to the ABC transporter superfamily
SIRE_RS11695	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SIRE_RS11730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SIRE_RS11735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SIRE_RS11735	COG1648	precorrin-2 dehydrogenase activity
SIRE_RS11740	COG2897	thiosulfate sulfurtransferase activity
SIRE_RS11770	COG0667	Aldo Keto reductase
SIRE_RS11790	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SIRE_RS11790	COG3608	succinylglutamate desuccinylase aspartoacylase
SIRE_RS11800	COG1960	acyl-CoA dehydrogenase activity
SIRE_RS11805	COG0318	PFAM AMP-dependent synthetase and ligase
SIRE_RS11820	COG1250	3-hydroxyacyl-CoA dehydrogenase
SIRE_RS11830	COG0281	malic enzyme
SIRE_RS11855	COG1584	GPR1 FUN34 yaaH family protein
SIRE_RS11860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SIRE_RS11895	COG0477	Major facilitator Superfamily
SIRE_RS11905	COG0395	ABC-type sugar transport system, permease component
SIRE_RS11970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIRE_RS11980	COG0517	IMP dehydrogenase activity
SIRE_RS11990	COG3387	PFAM Glycoside hydrolase 15-related
SIRE_RS12045	COG3387	PFAM Glycoside hydrolase 15-related
SIRE_RS12050	COG0438	transferase activity, transferring glycosyl groups
SIRE_RS12055	COG1013	pyruvate-flavodoxin oxidoreductase activity
SIRE_RS12060	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIRE_RS12065	COG1144	Oxidoreductase
SIRE_RS12070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SIRE_RS12075	COG0437	4 iron, 4 sulfur cluster binding
SIRE_RS12090	COG1960	acyl-CoA dehydrogenase activity
SIRE_RS12100	COG2086	electron transfer activity
SIRE_RS12110	COG0492	ferredoxin-NADP+ reductase activity
SIRE_RS12130	COG0402	S-adenosylhomocysteine deaminase activity
SIRE_RS12145	COG0028	Belongs to the TPP enzyme family
SIRE_RS12160	COG0644	oxidoreductase
SIRE_RS12170	COG0589	response to stress
SIRE_RS12175	COG0656	L-ascorbic acid biosynthetic process
SIRE_RS12180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SIRE_RS12185	COG0022	dehydrogenase e1 component
SIRE_RS12210	COG0586	Pfam SNARE associated Golgi protein
SIRE_RS12215	COG0668	transmembrane transport
SIRE_RS12275	COG0437	4 iron, 4 sulfur cluster binding
SIRE_RS12280	COG0243	molybdopterin cofactor binding
SIRE_RS12305	COG1063	alcohol dehydrogenase
SIRE_RS12345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SIRE_RS12395	COG0318	PFAM AMP-dependent synthetase and ligase
SIRE_RS12420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SIRE_RS12420	COG0674	pyruvate-flavodoxin oxidoreductase activity
SIRE_RS12425	COG1013	pyruvate-flavodoxin oxidoreductase activity
SIRE_RS12430	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SIRE_RS12435	COG0644	oxidoreductase
SIRE_RS12445	COG3848	Pyruvate phosphate dikinase
SIRE_RS12445	COG0574	Belongs to the PEP-utilizing enzyme family
SIRE_RS12450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SIRE_RS12460	COG3383	formate dehydrogenase (NAD+) activity
SIRE_RS12500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIRE_RS12510	COG0675	Transposase, IS605 OrfB family
SIRE_RS12540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIRE_RS12550	COG2223	nitrite transmembrane transporter activity
SIRE_RS12565	COG0395	ABC-type sugar transport system, permease component
SIRE_RS12570	COG3842	ATPase activity
SIRE_RS12600	COG0813	purine-nucleoside phosphorylase activity
SIRE_RS12605	COG3386	PFAM SMP-30 Gluconolaconase
SIRE_RS12610	COG2814	Major facilitator Superfamily
SIRE_RS12635	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SIRE_RS12675	COG0823	Involved in the tonB-independent uptake of proteins
SIRE_RS12675	COG1506	peptidase
SIRE_RS12675	COG4946	Tricorn protease homolog
SIRE_RS12690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIRE_RS12765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SIRE_RS12815	COG4608	Belongs to the ABC transporter superfamily
SIRE_RS12820	COG0444	Belongs to the ABC transporter superfamily
SIRE_RS12835	COG0601	transmembrane transport
SIRE_RS12850	COG4948	Mandelate Racemase Muconate Lactonizing
SIRE_RS12855	COG1028	Short-chain dehydrogenase reductase Sdr
SIRE_RS12910	COG2217	Heavy metal translocating P-type atpase
SIRE_RS12920	COG4555	ABC transporter
SIRE_RS12945	COG1592	Rubrerythrin
SIRE_RS12980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SIRE_RS13030	COG0183	Belongs to the thiolase family
SIRE_RS13040	COG1024	Enoyl-CoA hydratase
SIRE_RS13065	COG0601	transmembrane transport
SIRE_RS13070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SIRE_RS13075	COG0444	Belongs to the ABC transporter superfamily
SIRE_RS13080	COG4608	Belongs to the ABC transporter superfamily
SIRE_RS13090	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SIRE_RS13095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SIRE_RS13110	COG0438	transferase activity, transferring glycosyl groups
SIRE_RS13130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SIRE_RS13160	COG1131	(ABC) transporter
SIRE_RS13165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SIRE_RS13170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SIRE_RS13175	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SIRE_RS13195	COG0675	Transposase, IS605 OrfB family
SIRE_RS13205	COG0149	triose-phosphate isomerase activity
SIRE_RS13220	COG0372	Belongs to the citrate synthase family
SIRE_RS13225	COG0516	GMP reductase activity
SIRE_RS13225	COG0517	IMP dehydrogenase activity
SIRE_RS13230	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SIRE_RS13235	COG2079	MmgE PrpD family protein
SIRE_RS13240	COG0039	L-malate dehydrogenase activity
SIRE_RS13245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SIRE_RS13275	COG0750	zinc metalloprotease
SIRE_RS13295	COG1489	DNA binding
SIRE_RS13325	COG0778	Nitroreductase
SIRE_RS13330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIRE_RS13460	COG0308	aminopeptidase N
SIRE_RS13475	COG0561	phosphatase activity
SIRE_RS13485	COG1011	Hydrolase
SIRE_RS13505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SIRE_RS13535	COG0494	nUDIX hydrolase
SIRE_RS13545	COG3253	May function as heme-dependent peroxidase
SIRE_RS13560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SIRE_RS13590	COG2226	methyltransferase
SIRE_RS13615	COG0538	isocitrate dehydrogenase activity
SIRE_RS13765	COG1305	Transglutaminase-like
SIRE_RS13905	COG1215	transferase activity, transferring glycosyl groups
SIRE_RS13980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate