locus-tag	class	description
YG5714_RS00020	COG2154	pterin-4-alpha-carbinolamine dehydratase
YG5714_RS00100	COG1331	Highly conserved protein containing a thioredoxin domain
YG5714_RS00110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
YG5714_RS00120	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
YG5714_RS00145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
YG5714_RS00160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YG5714_RS00170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YG5714_RS00175	COG2814	Major facilitator Superfamily
YG5714_RS00185	COG0492	ferredoxin-NADP+ reductase activity
YG5714_RS00255	COG0588	phosphoglycerate mutase activity
YG5714_RS00275	COG1957	nucleoside hydrolase
YG5714_RS00325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YG5714_RS00325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YG5714_RS00330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YG5714_RS00335	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
YG5714_RS00365	COG0596	Alpha beta hydrolase
YG5714_RS00380	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
YG5714_RS00420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YG5714_RS00425	COG1573	uracil-dna glycosylase
YG5714_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
YG5714_RS00455	COG0215	cysteine-tRNA ligase activity
YG5714_RS00460	COG2222	sugar isomerase
YG5714_RS00470	COG0446	pyridine nucleotide-disulphide oxidoreductase
YG5714_RS00480	COG0433	COG0433 Predicted ATPase
YG5714_RS00490	COG1607	acyl-coa hydrolase
YG5714_RS00500	COG1028	Short-chain dehydrogenase reductase Sdr
YG5714_RS00505	COG0708	Exodeoxyribonuclease III
YG5714_RS00510	COG0515	serine threonine protein kinase
YG5714_RS00510	COG2815	serine threonine protein kinase
YG5714_RS00545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
YG5714_RS00545	COG1648	precorrin-2 dehydrogenase activity
YG5714_RS00555	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
YG5714_RS00575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YG5714_RS00585	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
YG5714_RS00695	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
YG5714_RS00700	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
YG5714_RS00715	COG0189	ligase activity
YG5714_RS00725	COG0493	'glutamate synthase
YG5714_RS00755	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
YG5714_RS00775	COG1053	succinate dehydrogenase
YG5714_RS00795	COG2304	oxidoreductase activity
YG5714_RS00800	COG0714	Associated with various cellular activities
YG5714_RS00820	COG0083	homoserine kinase activity
YG5714_RS00825	COG0626	cystathionine gamma-synthase activity
YG5714_RS00865	COG0183	Belongs to the thiolase family
YG5714_RS00870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YG5714_RS00910	COG1215	transferase activity, transferring glycosyl groups
YG5714_RS00915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YG5714_RS00925	COG0351	phosphomethylpyrimidine kinase
YG5714_RS00930	COG0314	molybdopterin synthase activity
YG5714_RS00955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
YG5714_RS00965	COG1131	(ABC) transporter
YG5714_RS00970	COG1668	transmembrane transport
YG5714_RS00995	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
YG5714_RS01000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
YG5714_RS01030	COG0720	synthase
YG5714_RS01055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YG5714_RS01075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
YG5714_RS01075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
YG5714_RS01085	COG0071	Belongs to the small heat shock protein (HSP20) family
YG5714_RS01145	COG0402	S-adenosylhomocysteine deaminase activity
YG5714_RS01170	COG0430	RNA-3'-phosphate cyclase activity
YG5714_RS01180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
YG5714_RS01185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YG5714_RS01190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YG5714_RS01200	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
YG5714_RS01205	COG5599	Phosphatase
YG5714_RS01210	COG1515	deoxyribonuclease V activity
YG5714_RS01215	COG1335	isochorismatase
YG5714_RS01250	COG4581	dead DEAH box helicase
YG5714_RS01260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
YG5714_RS01270	COG0439	Biotin carboxylase
YG5714_RS01280	COG1116	anion transmembrane transporter activity
YG5714_RS01290	COG0066	3-isopropylmalate dehydratase activity
YG5714_RS01295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
YG5714_RS01300	COG0415	Belongs to the DNA photolyase family
YG5714_RS01335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
YG5714_RS01375	COG0045	succinate-CoA ligase (ADP-forming) activity
YG5714_RS01390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
YG5714_RS01395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YG5714_RS01425	COG0657	acetylesterase activity
YG5714_RS01430	COG1063	alcohol dehydrogenase
YG5714_RS01435	COG0183	Belongs to the thiolase family
YG5714_RS01440	COG1960	acyl-CoA dehydrogenase activity
YG5714_RS01445	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YG5714_RS01450	COG1028	Short-chain dehydrogenase reductase Sdr
YG5714_RS01455	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
YG5714_RS01505	COG0318	PFAM AMP-dependent synthetase and ligase
YG5714_RS01510	COG1960	acyl-CoA dehydrogenase activity
YG5714_RS01515	COG1250	3-hydroxyacyl-CoA dehydrogenase
YG5714_RS01520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YG5714_RS01525	COG0477	Major facilitator Superfamily
YG5714_RS01525	COG2814	Major facilitator Superfamily
YG5714_RS01560	COG0318	PFAM AMP-dependent synthetase and ligase
YG5714_RS01570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YG5714_RS01575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YG5714_RS01605	COG3547	Transposase (IS116 IS110 IS902 family)
YG5714_RS01675	COG0432	Pfam Uncharacterised protein family UPF0047
YG5714_RS01680	COG1305	Transglutaminase-like
YG5714_RS01740	COG0450	alkyl hydroperoxide reductase
YG5714_RS01765	COG1620	l-lactate permease
YG5714_RS01780	COG0674	pyruvate-flavodoxin oxidoreductase activity
YG5714_RS01785	COG1013	pyruvate-flavodoxin oxidoreductase activity
YG5714_RS01790	COG1522	sequence-specific DNA binding
YG5714_RS01800	COG3573	Dehydrogenase
YG5714_RS01820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
YG5714_RS01825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
YG5714_RS01835	COG2062	phosphohistidine phosphatase, SixA
YG5714_RS01845	COG0674	pyruvate-flavodoxin oxidoreductase activity
YG5714_RS01900	COG0277	FAD linked oxidase domain protein
YG5714_RS01940	COG1024	Enoyl-CoA hydratase
YG5714_RS01950	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
YG5714_RS01965	COG1012	belongs to the aldehyde dehydrogenase family
YG5714_RS01980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YG5714_RS01985	COG0793	Belongs to the peptidase S41A family
YG5714_RS01985	COG4946	Tricorn protease homolog
YG5714_RS02030	COG0412	Dienelactone hydrolase
YG5714_RS02095	COG2084	Dehydrogenase
YG5714_RS02150	COG2050	protein possibly involved in aromatic compounds catabolism
YG5714_RS02150	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
YG5714_RS02155	COG2301	Belongs to the HpcH HpaI aldolase family
YG5714_RS02160	COG1802	Transcriptional regulator
YG5714_RS02175	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
YG5714_RS02190	COG2721	sulfolactate sulfo-lyase activity
YG5714_RS02195	COG2721	sulfolactate sulfo-lyase activity
YG5714_RS02220	COG1131	(ABC) transporter
YG5714_RS02225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YG5714_RS02240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YG5714_RS02275	COG4608	Belongs to the ABC transporter superfamily
YG5714_RS02280	COG0444	Belongs to the ABC transporter superfamily
YG5714_RS02290	COG0601	transmembrane transport
YG5714_RS02315	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
YG5714_RS02315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YG5714_RS02325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YG5714_RS02395	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
YG5714_RS02420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YG5714_RS02435	COG1960	acyl-CoA dehydrogenase activity
YG5714_RS02440	COG0318	PFAM AMP-dependent synthetase and ligase
YG5714_RS02470	COG1725	Transcriptional regulator
YG5714_RS02510	COG0243	molybdopterin cofactor binding
YG5714_RS02555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YG5714_RS02650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YG5714_RS02655	COG0477	Major facilitator Superfamily
YG5714_RS02665	COG1028	Short-chain dehydrogenase reductase Sdr
YG5714_RS02775	COG1201	RNA secondary structure unwinding
YG5714_RS02800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
YG5714_RS02835	COG1091	dTDP-4-dehydrorhamnose reductase activity
YG5714_RS02845	COG2224	Isocitrate lyase
YG5714_RS02850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YG5714_RS02890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YG5714_RS02895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YG5714_RS02930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YG5714_RS02935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YG5714_RS02970	COG2815	serine threonine protein kinase
YG5714_RS02970	COG0515	serine threonine protein kinase
YG5714_RS03240	COG1078	dGTPase activity
YG5714_RS03340	COG1131	(ABC) transporter
YG5714_RS03360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
YG5714_RS03425	COG3547	Transposase (IS116 IS110 IS902 family)
YG5714_RS03435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
YG5714_RS03455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
YG5714_RS03485	COG1473	amidohydrolase
YG5714_RS03725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YG5714_RS03770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YG5714_RS03795	COG4638	Rieske (2fe-2S)
YG5714_RS03850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
YG5714_RS03860	COG1063	alcohol dehydrogenase
YG5714_RS03865	COG2814	Major facilitator Superfamily
YG5714_RS03890	COG0508	dehydrogenase complex catalyzes the overall conversion of
YG5714_RS03895	COG3199	ATP-NAD kinase
YG5714_RS03900	COG0022	dehydrogenase e1 component
YG5714_RS03905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
YG5714_RS03910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YG5714_RS03920	COG0318	PFAM AMP-dependent synthetase and ligase
YG5714_RS03925	COG1250	3-hydroxyacyl-CoA dehydrogenase
YG5714_RS03945	COG0095	Lipoate-protein ligase
YG5714_RS03950	COG1960	acyl-CoA dehydrogenase activity
YG5714_RS03960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YG5714_RS03985	COG2030	dehydratase
YG5714_RS04005	COG4948	Mandelate Racemase Muconate Lactonizing
YG5714_RS04020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YG5714_RS04025	COG4689	acetoacetate decarboxylase
YG5714_RS04040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YG5714_RS04075	COG1073	alpha beta
YG5714_RS04105	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YG5714_RS04125	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
YG5714_RS04125	COG3608	succinylglutamate desuccinylase aspartoacylase
YG5714_RS04150	COG0717	Belongs to the dCTP deaminase family
YG5714_RS04175	COG1131	(ABC) transporter
YG5714_RS04230	COG2002	toxin-antitoxin pair type II binding
YG5714_RS04240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
YG5714_RS04245	COG0393	Putative heavy-metal-binding
YG5714_RS04375	COG0402	S-adenosylhomocysteine deaminase activity
YG5714_RS04385	COG1136	(ABC) transporter
YG5714_RS04385	COG0577	efflux transmembrane transporter activity
YG5714_RS04420	COG2226	methyltransferase
YG5714_RS04450	COG0501	Belongs to the peptidase M48B family
YG5714_RS04460	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
YG5714_RS04475	COG0589	response to stress
YG5714_RS04480	COG2151	metal-sulfur cluster biosynthetic enzyme
YG5714_RS04590	COG2226	methyltransferase
YG5714_RS04610	COG1042	CoA-binding domain protein
YG5714_RS04610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YG5714_RS04610	COG0045	succinate-CoA ligase (ADP-forming) activity
YG5714_RS04640	COG1136	(ABC) transporter
YG5714_RS04640	COG0577	efflux transmembrane transporter activity
YG5714_RS04650	COG1136	(ABC) transporter
YG5714_RS04670	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
YG5714_RS04700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
YG5714_RS04720	COG0425	Belongs to the sulfur carrier protein TusA family
YG5714_RS04730	COG1024	Enoyl-CoA hydratase
YG5714_RS04800	COG1011	Hydrolase
YG5714_RS04845	COG0477	Major facilitator Superfamily
YG5714_RS04855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YG5714_RS04860	COG1953	Uracil, thiamine, allantoin
YG5714_RS04865	COG0531	amino acid
YG5714_RS04870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
YG5714_RS04900	COG0477	Major facilitator Superfamily
YG5714_RS04930	COG2368	4-hydroxyphenylacetate
YG5714_RS04940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YG5714_RS04945	COG2271	Major facilitator Superfamily
YG5714_RS04955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YG5714_RS04960	COG1960	acyl-CoA dehydrogenase activity
YG5714_RS05010	COG1012	belongs to the aldehyde dehydrogenase family
YG5714_RS05015	COG0535	radical SAM domain protein
YG5714_RS05020	COG0535	radical SAM domain protein
YG5714_RS05075	COG2271	Major facilitator Superfamily
YG5714_RS05085	COG0436	Aminotransferase
YG5714_RS05120	COG1175	transmembrane transport
YG5714_RS05125	COG3833	ABC-type maltose transport systems, permease component
YG5714_RS05130	COG3842	ATPase activity
YG5714_RS05140	COG2814	Major facilitator Superfamily
YG5714_RS05190	COG1960	acyl-CoA dehydrogenase activity
YG5714_RS05230	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
YG5714_RS05235	COG1131	(ABC) transporter
YG5714_RS05260	COG0475	glutathione-regulated potassium exporter activity
YG5714_RS05285	COG2048	Heterodisulfide reductase, subunit B
YG5714_RS05315	COG0425	Belongs to the sulfur carrier protein TusA family
YG5714_RS05320	COG2210	Belongs to the sulfur carrier protein TusA family
YG5714_RS05365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
YG5714_RS05375	COG0095	Lipoate-protein ligase
YG5714_RS05380	COG1832	CoA-binding protein
YG5714_RS05410	COG0509	glycine decarboxylation via glycine cleavage system
YG5714_RS05420	COG2271	Major facilitator Superfamily
YG5714_RS05455	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YG5714_RS05500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
YG5714_RS05510	COG1846	Transcriptional regulator
YG5714_RS05515	COG0577	efflux transmembrane transporter activity
YG5714_RS05515	COG1136	(ABC) transporter
YG5714_RS05525	COG1136	(ABC) transporter
YG5714_RS05530	COG0114	fumarate hydratase activity
YG5714_RS05540	COG0517	IMP dehydrogenase activity
YG5714_RS05545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YG5714_RS05545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
YG5714_RS05550	COG0531	amino acid
YG5714_RS05565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
YG5714_RS05570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
YG5714_RS05590	COG0509	glycine decarboxylation via glycine cleavage system
YG5714_RS05630	COG0004	ammonium transporteR
YG5714_RS05650	COG1185	polyribonucleotide nucleotidyltransferase activity
YG5714_RS05695	COG1234	tRNA 3'-trailer cleavage
YG5714_RS05710	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
YG5714_RS05755	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
YG5714_RS05760	COG0725	ABC transporter, periplasmic molybdate-binding protein
YG5714_RS05765	COG0300	oxidoreductase activity
YG5714_RS05770	COG3383	formate dehydrogenase (NAD+) activity
YG5714_RS05785	COG0650	Formate hydrogenlyase subunit 4
YG5714_RS05795	COG0651	ATP synthesis coupled electron transport
YG5714_RS05800	COG0649	NAD binding
YG5714_RS05805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YG5714_RS05810	COG0651	ATP synthesis coupled electron transport
YG5714_RS05820	COG2897	thiosulfate sulfurtransferase activity
YG5714_RS05825	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
YG5714_RS05840	COG0028	Belongs to the TPP enzyme family
YG5714_RS05845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YG5714_RS05880	COG0395	ABC-type sugar transport system, permease component
YG5714_RS05895	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
YG5714_RS05900	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
YG5714_RS05905	COG0157	Belongs to the NadC ModD family
YG5714_RS05935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
YG5714_RS05945	COG0297	glycogen (starch) synthase activity
YG5714_RS05955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YG5714_RS05980	COG0469	pyruvate kinase activity
YG5714_RS05995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
YG5714_RS06005	COG0528	UMP kinase activity
YG5714_RS06015	COG1028	Short-chain dehydrogenase reductase Sdr
YG5714_RS06030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YG5714_RS06035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
YG5714_RS06045	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
YG5714_RS06075	COG1110	DNA topoisomerase II activity
YG5714_RS06115	COG0154	amidase activity
YG5714_RS06130	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
YG5714_RS06130	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
YG5714_RS06185	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
YG5714_RS06215	COG0252	asparaginase activity
YG5714_RS06220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
YG5714_RS06290	COG1372	Participates in initiation and elongation during chromosome replication
YG5714_RS06290	COG0719	Fe-S assembly protein
YG5714_RS06295	COG0719	Fe-S assembly protein
YG5714_RS06300	COG0396	ATPase activity
YG5714_RS06320	COG0509	glycine decarboxylation via glycine cleavage system
YG5714_RS06325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
YG5714_RS06335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
YG5714_RS06355	COG0148	phosphopyruvate hydratase activity
YG5714_RS06375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YG5714_RS06380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YG5714_RS06395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YG5714_RS06425	COG0644	oxidoreductase
YG5714_RS06430	COG0525	valine-tRNA ligase activity
YG5714_RS06435	COG0436	Aminotransferase
YG5714_RS06440	COG0134	indole-3-glycerol-phosphate synthase activity
YG5714_RS06445	COG0512	Glutamine amidotransferase of anthranilate synthase
YG5714_RS06445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YG5714_RS06450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
YG5714_RS06455	COG0135	phosphoribosylanthranilate isomerase activity
YG5714_RS06465	COG0159	tryptophan synthase activity
YG5714_RS06470	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
YG5714_RS06475	COG1254	Belongs to the acylphosphatase family
YG5714_RS06480	COG1260	myo-inositol-1-phosphate synthase
YG5714_RS06485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YG5714_RS06485	COG0574	Belongs to the PEP-utilizing enzyme family
YG5714_RS06505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
YG5714_RS06510	COG0460	homoserine dehydrogenase
YG5714_RS06510	COG0527	aspartate kinase activity
YG5714_RS06530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
YG5714_RS06565	COG0459	protein refolding
YG5714_RS06610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
YG5714_RS06670	COG0315	cyclic pyranopterin monophosphate synthase activity
YG5714_RS06675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YG5714_RS06680	COG2255	four-way junction helicase activity
YG5714_RS06685	COG1881	PFAM PEBP family protein
YG5714_RS06690	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
YG5714_RS06700	COG1063	alcohol dehydrogenase
YG5714_RS06725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
YG5714_RS06730	COG0371	Dehydrogenase
YG5714_RS06735	COG1047	Peptidyl-prolyl cis-trans
YG5714_RS06750	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
YG5714_RS06765	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
YG5714_RS06800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
YG5714_RS06805	COG2264	protein methyltransferase activity
YG5714_RS06810	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
YG5714_RS06820	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YG5714_RS06865	COG1185	polyribonucleotide nucleotidyltransferase activity
YG5714_RS06890	COG0322	excinuclease ABC activity
YG5714_RS06895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
YG5714_RS06915	COG0473	3-isopropylmalate dehydrogenase activity
YG5714_RS06920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
YG5714_RS06930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
YG5714_RS06945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
YG5714_RS06950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YG5714_RS06955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
YG5714_RS06960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YG5714_RS06965	COG0255	Belongs to the universal ribosomal protein uL29 family
YG5714_RS06975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YG5714_RS06980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YG5714_RS06985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
YG5714_RS06995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
YG5714_RS07005	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YG5714_RS07010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
YG5714_RS07030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
YG5714_RS07065	COG0563	adenylate kinase activity
YG5714_RS07130	COG0069	glutamate synthase activity
YG5714_RS07135	COG0067	glutamate synthase
YG5714_RS07150	COG0402	S-adenosylhomocysteine deaminase activity
YG5714_RS07165	COG0303	'Molybdopterin
YG5714_RS07200	COG1321	iron dependent repressor
YG5714_RS07210	COG2379	hydroxypyruvate reductase
YG5714_RS07215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YG5714_RS07220	COG0009	L-threonylcarbamoyladenylate synthase
YG5714_RS07230	COG0312	modulator of DNA gyrase
YG5714_RS07235	COG0312	modulator of DNA gyrase
YG5714_RS07240	COG0864	Transcriptional regulator
YG5714_RS07250	COG0460	homoserine dehydrogenase
YG5714_RS07265	COG1024	Enoyl-CoA hydratase
YG5714_RS07305	COG1250	3-hydroxyacyl-CoA dehydrogenase
YG5714_RS07315	COG0189	ligase activity
YG5714_RS07325	COG0505	Belongs to the CarA family
YG5714_RS07330	COG0165	Argininosuccinate lyase
YG5714_RS07335	COG0137	argininosuccinate synthase activity
YG5714_RS07350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
YG5714_RS07355	COG0151	Belongs to the GarS family
YG5714_RS07360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
YG5714_RS07365	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
YG5714_RS07375	COG0047	phosphoribosylformylglycinamidine synthase activity
YG5714_RS07385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
YG5714_RS07390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YG5714_RS07390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YG5714_RS07395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
YG5714_RS07400	COG0602	queuosine metabolic process
YG5714_RS07435	COG0284	orotidine-5'-phosphate decarboxylase activity
YG5714_RS07440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
YG5714_RS07445	COG0540	Belongs to the ATCase OTCase family
YG5714_RS07450	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
YG5714_RS07465	COG0167	dihydroorotate dehydrogenase activity
YG5714_RS07480	COG2095	MarC family integral membrane protein
YG5714_RS07485	COG1522	sequence-specific DNA binding
YG5714_RS07500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YG5714_RS07505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
YG5714_RS07510	COG2151	metal-sulfur cluster biosynthetic enzyme
YG5714_RS07520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
YG5714_RS07525	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YG5714_RS07525	COG0140	phosphoribosyl-ATP diphosphatase activity
YG5714_RS07530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YG5714_RS07535	COG0107	imidazoleglycerol-phosphate synthase activity
YG5714_RS07540	COG0131	Imidazoleglycerol-phosphate dehydratase
YG5714_RS07545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
YG5714_RS07550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
YG5714_RS07555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YG5714_RS07565	COG0495	leucyl-tRNA aminoacylation
YG5714_RS07570	COG2096	Adenosyltransferase
YG5714_RS07575	COG0037	tRNA processing
YG5714_RS07585	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
YG5714_RS07610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
YG5714_RS07620	COG0028	Belongs to the TPP enzyme family
YG5714_RS07630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
YG5714_RS07645	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
YG5714_RS07650	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
YG5714_RS07660	COG0442	prolyl-tRNA aminoacylation
YG5714_RS07675	COG1394	ATPase activity, coupled to movement of substances
YG5714_RS07685	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
YG5714_RS07705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YG5714_RS07735	COG0417	DNA replication proofreading
YG5714_RS07750	COG0668	transmembrane transport
YG5714_RS07760	COG0126	phosphoglycerate kinase activity
YG5714_RS07770	COG0589	response to stress
YG5714_RS07775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
YG5714_RS07795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YG5714_RS07800	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
YG5714_RS07825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
YG5714_RS07875	COG4974	Belongs to the 'phage' integrase family
YG5714_RS08035	COG1192	Involved in chromosome partitioning
YG5714_RS08260	COG0495	leucyl-tRNA aminoacylation
YG5714_RS08310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
YG5714_RS08325	COG0581	inorganic phosphate transmembrane transporter activity
YG5714_RS08340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
YG5714_RS08345	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YG5714_RS08360	COG0805	protein transport
YG5714_RS08370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YG5714_RS08395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YG5714_RS08405	COG0556	nucleotide-excision repair
YG5714_RS08410	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
YG5714_RS08420	COG3276	selenocysteine insertion sequence binding
YG5714_RS08440	COG0351	phosphomethylpyrimidine kinase
YG5714_RS08440	COG1992	Thiamine-phosphate synthase
YG5714_RS08470	COG0489	protein tyrosine kinase activity
YG5714_RS08490	COG1280	lysine exporter protein (LysE YggA)
YG5714_RS08520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YG5714_RS08530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
YG5714_RS08685	COG0423	glycine-tRNA ligase activity
YG5714_RS08715	COG0163	prenyltransferase activity
YG5714_RS08720	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
YG5714_RS08740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
YG5714_RS08745	COG0667	Aldo Keto reductase
YG5714_RS08790	COG1110	DNA topoisomerase II activity
YG5714_RS08795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YG5714_RS08800	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
YG5714_RS08815	COG0539	negative regulation of cytoplasmic translation
YG5714_RS08825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
YG5714_RS08860	COG1797	cobyrinic acid a,c-diamide synthase activity
YG5714_RS08880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
YG5714_RS08890	COG0402	S-adenosylhomocysteine deaminase activity
YG5714_RS08910	COG1201	RNA secondary structure unwinding
YG5714_RS08925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
YG5714_RS08930	COG2813	Specifically methylates the guanine in position
YG5714_RS08940	COG1444	tRNA N-acetyltransferase activity
YG5714_RS08985	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
YG5714_RS08990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
YG5714_RS09000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
YG5714_RS09025	COG0475	glutathione-regulated potassium exporter activity
YG5714_RS09035	COG0535	radical SAM domain protein
YG5714_RS09040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YG5714_RS09045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
YG5714_RS09045	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
YG5714_RS09055	COG0318	PFAM AMP-dependent synthetase and ligase
YG5714_RS09060	COG3118	belongs to the thioredoxin family
YG5714_RS09065	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
YG5714_RS09070	COG0174	glutamine synthetase
YG5714_RS09080	COG0302	gtp cyclohydrolase
YG5714_RS09090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YG5714_RS09105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
YG5714_RS09170	COG0552	protein localization to endoplasmic reticulum
YG5714_RS09185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
YG5714_RS09195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
YG5714_RS09205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
YG5714_RS09235	COG0301	tRNA thio-modification
YG5714_RS09240	COG1260	myo-inositol-1-phosphate synthase
YG5714_RS09245	COG1007	ATP synthesis coupled electron transport
YG5714_RS09250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YG5714_RS09255	COG0713	ATP synthesis coupled electron transport
YG5714_RS09265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YG5714_RS09270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
YG5714_RS09275	COG0649	NAD binding
YG5714_RS09280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YG5714_RS09290	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
YG5714_RS09310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
YG5714_RS09315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YG5714_RS09355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
YG5714_RS09365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
YG5714_RS09370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YG5714_RS09375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
YG5714_RS09380	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
YG5714_RS09385	COG0077	Prephenate dehydratase
YG5714_RS09385	COG1605	Chorismate mutase
YG5714_RS09390	COG3958	Transketolase
YG5714_RS09395	COG3959	Transketolase, thiamine diphosphate binding domain
YG5714_RS09400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YG5714_RS09420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YG5714_RS09430	COG1185	polyribonucleotide nucleotidyltransferase activity
YG5714_RS09455	COG0477	Major facilitator Superfamily
YG5714_RS09465	COG1121	(ABC) transporter
YG5714_RS09470	COG1980	fructose-bisphosphate aldolase activity
YG5714_RS09495	COG0459	protein refolding
YG5714_RS09510	COG0124	histidyl-tRNA synthetase
YG5714_RS09545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YG5714_RS09555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YG5714_RS09595	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
YG5714_RS09630	COG1051	belongs to the nudix hydrolase family
YG5714_RS09630	COG1056	cytidyltransferase-related domain
YG5714_RS09645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
YG5714_RS09645	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
YG5714_RS09670	COG1605	Chorismate mutase
YG5714_RS09670	COG0077	Prephenate dehydratase
YG5714_RS09685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
YG5714_RS09700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YG5714_RS09715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YG5714_RS09730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
YG5714_RS09735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
YG5714_RS09750	COG0105	UTP biosynthetic process
YG5714_RS09765	COG0085	RNA polymerase activity
YG5714_RS09770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YG5714_RS09775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YG5714_RS09800	COG0049	tRNA binding
YG5714_RS09805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
YG5714_RS09810	COG0051	transcription antitermination factor activity, RNA binding
YG5714_RS09850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
YG5714_RS09855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YG5714_RS09915	COG1373	ATPase (AAA superfamily
YG5714_RS09990	COG1401	restriction endodeoxyribonuclease activity
YG5714_RS09995	COG1489	DNA binding
YG5714_RS10065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YG5714_RS10085	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
YG5714_RS10090	COG0504	CTP synthase activity
YG5714_RS10105	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
YG5714_RS10135	COG2078	PFAM AMMECR1 domain protein
YG5714_RS10150	COG0717	Belongs to the dCTP deaminase family
YG5714_RS10155	COG1793	dna ligase
YG5714_RS10160	COG1793	dna ligase
YG5714_RS10160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
YG5714_RS10165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
YG5714_RS10190	COG0181	hydroxymethylbilane synthase activity
YG5714_RS10195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
YG5714_RS10200	COG0113	porphobilinogen synthase activity
YG5714_RS10205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
YG5714_RS10225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YG5714_RS10245	COG0585	pseudouridine synthase activity
YG5714_RS10250	COG0017	Asparaginyl-tRNA synthetase
YG5714_RS10265	COG0028	Belongs to the TPP enzyme family
YG5714_RS10280	COG1122	ATPase activity
YG5714_RS10315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
YG5714_RS10320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YG5714_RS10325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
YG5714_RS10330	COG0189	ligase activity
YG5714_RS10345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
YG5714_RS10350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YG5714_RS10365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YG5714_RS10410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YG5714_RS10445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
YG5714_RS10500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YG5714_RS10515	COG1201	RNA secondary structure unwinding
YG5714_RS10520	COG0517	IMP dehydrogenase activity
YG5714_RS10520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
YG5714_RS10520	COG0617	tRNA 3'-terminal CCA addition
YG5714_RS10545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YG5714_RS10550	COG1546	Belongs to the CinA family
YG5714_RS10550	COG1058	Belongs to the CinA family
YG5714_RS10555	COG2267	carboxylic ester hydrolase activity
YG5714_RS10570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
YG5714_RS10595	COG1078	dGTPase activity
YG5714_RS10600	COG0561	phosphatase activity
YG5714_RS10605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YG5714_RS10620	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
YG5714_RS10650	COG0456	acetyltransferase
YG5714_RS10650	COG1214	PFAM Peptidase M22, glycoprotease
YG5714_RS10665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
YG5714_RS10680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
YG5714_RS10685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YG5714_RS10690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
YG5714_RS10700	COG0200	Binds to the 23S rRNA
YG5714_RS10705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
YG5714_RS10710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
YG5714_RS10720	COG0052	Belongs to the universal ribosomal protein uS2 family
YG5714_RS10725	COG1355	regulation of microtubule-based process
YG5714_RS10740	COG1304	FMN binding
YG5714_RS10800	COG1131	(ABC) transporter
YG5714_RS10830	COG0084	hydrolase, TatD family'
YG5714_RS10845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YG5714_RS10885	COG1192	Involved in chromosome partitioning
YG5714_RS10905	COG3620	sequence-specific DNA binding
YG5714_RS10905	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
YG5714_RS10905	COG0617	tRNA 3'-terminal CCA addition
YG5714_RS10915	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
YG5714_RS10960	COG1201	RNA secondary structure unwinding
YG5714_RS10970	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
YG5714_RS10995	COG2860	membrane
YG5714_RS11010	COG0123	including yeast histone deacetylase and acetoin utilization protein
YG5714_RS11030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YG5714_RS11035	COG0351	phosphomethylpyrimidine kinase
YG5714_RS11035	COG0352	thiamine-phosphate diphosphorylase activity
YG5714_RS11045	COG1215	transferase activity, transferring glycosyl groups
YG5714_RS11095	COG0463	Glycosyl transferase, family 2
YG5714_RS11115	COG1063	alcohol dehydrogenase
YG5714_RS11135	COG0519	Catalyzes the synthesis of GMP from XMP
YG5714_RS11135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
YG5714_RS11140	COG0501	Belongs to the peptidase M48B family
YG5714_RS11145	COG0517	IMP dehydrogenase activity
YG5714_RS11145	COG0516	GMP reductase activity
YG5714_RS11155	COG1830	Aldolase
YG5714_RS11180	COG0405	Gamma-glutamyltransferase
YG5714_RS11195	COG1444	tRNA N-acetyltransferase activity
YG5714_RS11210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
YG5714_RS11220	COG0656	L-ascorbic acid biosynthetic process
YG5714_RS11235	COG0251	oxidation-reduction process
YG5714_RS11240	COG0517	IMP dehydrogenase activity
YG5714_RS11240	COG0516	GMP reductase activity
YG5714_RS11245	COG1063	alcohol dehydrogenase
YG5714_RS11250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YG5714_RS11260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
YG5714_RS11270	COG4948	Mandelate Racemase Muconate Lactonizing
YG5714_RS11275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YG5714_RS11280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YG5714_RS11285	COG1012	belongs to the aldehyde dehydrogenase family
YG5714_RS11290	COG0530	calcium, potassium:sodium antiporter activity
YG5714_RS11295	COG0243	molybdopterin cofactor binding
YG5714_RS11340	COG0833	amino acid
YG5714_RS11345	COG0589	response to stress
YG5714_RS11360	COG2814	Major facilitator Superfamily
YG5714_RS11435	COG1733	regulation of RNA biosynthetic process
YG5714_RS11445	COG0517	IMP dehydrogenase activity
YG5714_RS11445	COG0516	GMP reductase activity
YG5714_RS11450	COG1720	tRNA m6t6A37 methyltransferase activity
YG5714_RS11490	COG0277	FAD linked oxidase domain protein
YG5714_RS11495	COG0247	lactate metabolic process
YG5714_RS11500	COG0095	Lipoate-protein ligase
YG5714_RS11505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
YG5714_RS11520	COG0655	NAD(P)H dehydrogenase (quinone) activity
YG5714_RS11565	COG0477	Major facilitator Superfamily
YG5714_RS11575	COG1960	acyl-CoA dehydrogenase activity
YG5714_RS11585	COG2271	Major facilitator Superfamily
YG5714_RS11615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YG5714_RS11640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YG5714_RS11650	COG1139	Iron-sulfur cluster binding protein
YG5714_RS11655	COG2814	Major facilitator Superfamily
YG5714_RS11670	COG4948	Mandelate Racemase Muconate Lactonizing
YG5714_RS11680	COG0477	Major facilitator Superfamily
YG5714_RS11685	COG2271	Major facilitator Superfamily
YG5714_RS11690	COG0179	Fumarylacetoacetate (FAA) hydrolase
YG5714_RS11705	COG2267	carboxylic ester hydrolase activity
YG5714_RS11715	COG1028	Short-chain dehydrogenase reductase Sdr
YG5714_RS11770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
YG5714_RS11810	COG1122	ATPase activity
YG5714_RS11850	COG0425	Belongs to the sulfur carrier protein TusA family
YG5714_RS11870	COG1136	(ABC) transporter
YG5714_RS11920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YG5714_RS11940	COG0318	PFAM AMP-dependent synthetase and ligase
YG5714_RS11990	COG0673	inositol 2-dehydrogenase activity
YG5714_RS12000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YG5714_RS12005	COG0444	Belongs to the ABC transporter superfamily
YG5714_RS12010	COG4608	Belongs to the ABC transporter superfamily
YG5714_RS12055	COG3250	beta-galactosidase activity
YG5714_RS12060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YG5714_RS12065	COG1472	Belongs to the glycosyl hydrolase 3 family
YG5714_RS12130	COG3408	Glycogen debranching enzyme
YG5714_RS12155	COG1501	Belongs to the glycosyl hydrolase 31 family
YG5714_RS12165	COG2723	6-phospho-beta-galactosidase activity
YG5714_RS12190	COG0667	Aldo Keto reductase
YG5714_RS12200	COG1132	(ABC) transporter
YG5714_RS12220	COG0673	inositol 2-dehydrogenase activity
YG5714_RS12235	COG1028	Short-chain dehydrogenase reductase Sdr
YG5714_RS12250	COG0459	protein refolding
YG5714_RS12255	COG4948	Mandelate Racemase Muconate Lactonizing
YG5714_RS12260	COG1250	3-hydroxyacyl-CoA dehydrogenase
YG5714_RS12265	COG1914	H( )-stimulated, divalent metal cation uptake system
YG5714_RS12345	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
YG5714_RS12370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YG5714_RS12385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
YG5714_RS12385	COG2857	Cytochrome c1
YG5714_RS12435	COG0601	transmembrane transport
YG5714_RS12440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YG5714_RS12445	COG0444	Belongs to the ABC transporter superfamily
YG5714_RS12450	COG4608	Belongs to the ABC transporter superfamily
YG5714_RS12505	COG0179	Fumarylacetoacetate (FAA) hydrolase
YG5714_RS12565	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YG5714_RS12575	COG2897	thiosulfate sulfurtransferase activity
YG5714_RS12615	COG0667	Aldo Keto reductase
YG5714_RS12645	COG3608	succinylglutamate desuccinylase aspartoacylase
YG5714_RS12645	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
YG5714_RS12655	COG1960	acyl-CoA dehydrogenase activity
YG5714_RS12660	COG0318	PFAM AMP-dependent synthetase and ligase
YG5714_RS12675	COG1250	3-hydroxyacyl-CoA dehydrogenase
YG5714_RS12685	COG0281	malic enzyme
YG5714_RS12710	COG1584	GPR1 FUN34 yaaH family protein
YG5714_RS12715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
YG5714_RS12750	COG0477	Major facilitator Superfamily
YG5714_RS12755	COG3842	ATPase activity
YG5714_RS12760	COG0395	ABC-type sugar transport system, permease component
YG5714_RS12815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
YG5714_RS12855	COG3383	formate dehydrogenase (NAD+) activity
YG5714_RS12865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
YG5714_RS12870	COG0574	Belongs to the PEP-utilizing enzyme family
YG5714_RS12870	COG3848	Pyruvate phosphate dikinase
YG5714_RS12885	COG3547	Transposase (IS116 IS110 IS902 family)
YG5714_RS12930	COG0644	oxidoreductase
YG5714_RS12935	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
YG5714_RS12940	COG1013	pyruvate-flavodoxin oxidoreductase activity
YG5714_RS12945	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YG5714_RS12945	COG0674	pyruvate-flavodoxin oxidoreductase activity
YG5714_RS12975	COG0318	PFAM AMP-dependent synthetase and ligase
YG5714_RS13025	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
YG5714_RS13065	COG1063	alcohol dehydrogenase
YG5714_RS13095	COG0437	4 iron, 4 sulfur cluster binding
YG5714_RS13165	COG1968	undecaprenyl-diphosphatase activity
YG5714_RS13210	COG0668	transmembrane transport
YG5714_RS13215	COG0586	Pfam SNARE associated Golgi protein
YG5714_RS13220	COG2002	toxin-antitoxin pair type II binding
YG5714_RS13225	COG0022	dehydrogenase e1 component
YG5714_RS13230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
YG5714_RS13235	COG0656	L-ascorbic acid biosynthetic process
YG5714_RS13240	COG0589	response to stress
YG5714_RS13250	COG0644	oxidoreductase
YG5714_RS13265	COG0028	Belongs to the TPP enzyme family
YG5714_RS13280	COG0402	S-adenosylhomocysteine deaminase activity
YG5714_RS13300	COG0492	ferredoxin-NADP+ reductase activity
YG5714_RS13310	COG2086	electron transfer activity
YG5714_RS13320	COG1960	acyl-CoA dehydrogenase activity
YG5714_RS13335	COG0437	4 iron, 4 sulfur cluster binding
YG5714_RS13340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YG5714_RS13345	COG1144	Oxidoreductase
YG5714_RS13350	COG0674	pyruvate-flavodoxin oxidoreductase activity
YG5714_RS13355	COG1013	pyruvate-flavodoxin oxidoreductase activity
YG5714_RS13360	COG0438	transferase activity, transferring glycosyl groups
YG5714_RS13365	COG3387	PFAM Glycoside hydrolase 15-related
YG5714_RS13450	COG0517	IMP dehydrogenase activity
YG5714_RS13460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YG5714_RS13530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
YG5714_RS13545	COG1063	alcohol dehydrogenase
YG5714_RS13555	COG0395	ABC-type sugar transport system, permease component
YG5714_RS13560	COG3842	ATPase activity
YG5714_RS13590	COG0813	purine-nucleoside phosphorylase activity
YG5714_RS13595	COG3386	PFAM SMP-30 Gluconolaconase
YG5714_RS13600	COG2814	Major facilitator Superfamily
YG5714_RS13630	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
YG5714_RS13650	COG4274	PFAM GYD family protein
YG5714_RS13660	COG1506	peptidase
YG5714_RS13660	COG0823	Involved in the tonB-independent uptake of proteins
YG5714_RS13660	COG4946	Tricorn protease homolog
YG5714_RS13675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YG5714_RS13760	COG4608	Belongs to the ABC transporter superfamily
YG5714_RS13765	COG0444	Belongs to the ABC transporter superfamily
YG5714_RS13780	COG3547	Transposase (IS116 IS110 IS902 family)
YG5714_RS13790	COG0601	transmembrane transport
YG5714_RS13805	COG4948	Mandelate Racemase Muconate Lactonizing
YG5714_RS13810	COG1028	Short-chain dehydrogenase reductase Sdr
YG5714_RS13830	COG0723	plastoquinol--plastocyanin reductase activity
YG5714_RS13865	COG2217	Heavy metal translocating P-type atpase
YG5714_RS13875	COG4555	ABC transporter
YG5714_RS13895	COG3547	Transposase (IS116 IS110 IS902 family)
YG5714_RS13910	COG1592	Rubrerythrin
YG5714_RS13945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YG5714_RS13995	COG0183	Belongs to the thiolase family
YG5714_RS14005	COG1024	Enoyl-CoA hydratase
YG5714_RS14045	COG0601	transmembrane transport
YG5714_RS14050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YG5714_RS14055	COG0444	Belongs to the ABC transporter superfamily
YG5714_RS14060	COG4608	Belongs to the ABC transporter superfamily
YG5714_RS14070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YG5714_RS14075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YG5714_RS14090	COG0438	transferase activity, transferring glycosyl groups
YG5714_RS14110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
YG5714_RS14135	COG1131	(ABC) transporter
YG5714_RS14140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
YG5714_RS14145	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
YG5714_RS14150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YG5714_RS14170	COG0149	triose-phosphate isomerase activity
YG5714_RS14185	COG0372	Belongs to the citrate synthase family
YG5714_RS14190	COG0516	GMP reductase activity
YG5714_RS14190	COG0517	IMP dehydrogenase activity
YG5714_RS14195	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
YG5714_RS14200	COG2079	MmgE PrpD family protein
YG5714_RS14205	COG0039	L-malate dehydrogenase activity
YG5714_RS14210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YG5714_RS14240	COG0750	zinc metalloprotease
YG5714_RS14260	COG1489	DNA binding
YG5714_RS14290	COG0778	Nitroreductase
YG5714_RS14295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YG5714_RS14440	COG0561	phosphatase activity
YG5714_RS14450	COG1011	Hydrolase
YG5714_RS14465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YG5714_RS14500	COG0494	nUDIX hydrolase
YG5714_RS14510	COG3253	May function as heme-dependent peroxidase
YG5714_RS14525	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YG5714_RS14555	COG2226	methyltransferase
YG5714_RS14580	COG0538	isocitrate dehydrogenase activity
YG5714_RS14735	COG0444	Belongs to the ABC transporter superfamily
YG5714_RS14795	COG1305	Transglutaminase-like
YG5714_RS14825	COG0438	transferase activity, transferring glycosyl groups
YG5714_RS14920	COG0318	PFAM AMP-dependent synthetase and ligase
YG5714_RS15030	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate