locus-tag	class	description
SULC_RS00005	COG0538	isocitrate dehydrogenase activity
SULC_RS00025	COG2154	pterin-4-alpha-carbinolamine dehydratase
SULC_RS00105	COG1331	Highly conserved protein containing a thioredoxin domain
SULC_RS00110	COG1028	Short-chain dehydrogenase reductase Sdr
SULC_RS00115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SULC_RS00125	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SULC_RS00150	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SULC_RS00165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SULC_RS00190	COG0492	ferredoxin-NADP+ reductase activity
SULC_RS00235	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
SULC_RS00260	COG0588	phosphoglycerate mutase activity
SULC_RS00290	COG1957	nucleoside hydrolase
SULC_RS00295	COG0735	belongs to the Fur family
SULC_RS00320	COG0497	DNA recombination
SULC_RS00340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SULC_RS00340	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SULC_RS00345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SULC_RS00350	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
SULC_RS00385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SULC_RS00430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SULC_RS00435	COG1573	uracil-dna glycosylase
SULC_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
SULC_RS00465	COG0215	cysteine-tRNA ligase activity
SULC_RS00470	COG2222	sugar isomerase
SULC_RS00480	COG0446	pyridine nucleotide-disulphide oxidoreductase
SULC_RS00490	COG0433	COG0433 Predicted ATPase
SULC_RS00500	COG1607	acyl-coa hydrolase
SULC_RS00515	COG0708	Exodeoxyribonuclease III
SULC_RS00520	COG2815	serine threonine protein kinase
SULC_RS00520	COG0515	serine threonine protein kinase
SULC_RS00585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SULC_RS00730	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SULC_RS00735	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SULC_RS00750	COG0189	ligase activity
SULC_RS00790	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SULC_RS00810	COG1053	succinate dehydrogenase
SULC_RS00830	COG2304	oxidoreductase activity
SULC_RS00835	COG0714	Associated with various cellular activities
SULC_RS00855	COG0083	homoserine kinase activity
SULC_RS00860	COG0626	cystathionine gamma-synthase activity
SULC_RS00900	COG0183	Belongs to the thiolase family
SULC_RS00905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SULC_RS00950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SULC_RS00960	COG0351	phosphomethylpyrimidine kinase
SULC_RS00965	COG0314	molybdopterin synthase activity
SULC_RS01000	COG1131	(ABC) transporter
SULC_RS01005	COG1668	transmembrane transport
SULC_RS01025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SULC_RS01030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SULC_RS01060	COG0720	synthase
SULC_RS01075	COG0492	ferredoxin-NADP+ reductase activity
SULC_RS01080	COG0483	inositol monophosphate 1-phosphatase activity
SULC_RS01085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SULC_RS01100	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SULC_RS01105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SULC_RS01105	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SULC_RS01115	COG0071	Belongs to the small heat shock protein (HSP20) family
SULC_RS01175	COG0402	S-adenosylhomocysteine deaminase activity
SULC_RS01200	COG0430	RNA-3'-phosphate cyclase activity
SULC_RS01215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SULC_RS01220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SULC_RS01230	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SULC_RS01240	COG1515	deoxyribonuclease V activity
SULC_RS01285	COG4581	dead DEAH box helicase
SULC_RS01290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SULC_RS01300	COG0439	Biotin carboxylase
SULC_RS01310	COG1116	anion transmembrane transporter activity
SULC_RS01315	COG0066	3-isopropylmalate dehydratase activity
SULC_RS01320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SULC_RS01380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SULC_RS01400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SULC_RS01405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SULC_RS01420	COG0045	succinate-CoA ligase (ADP-forming) activity
SULC_RS01490	COG1063	alcohol dehydrogenase
SULC_RS01495	COG0183	Belongs to the thiolase family
SULC_RS01500	COG1960	acyl-CoA dehydrogenase activity
SULC_RS01505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SULC_RS01510	COG1028	Short-chain dehydrogenase reductase Sdr
SULC_RS01515	COG1064	alcohol dehydrogenase
SULC_RS01535	COG1309	transcriptional regulator
SULC_RS01560	COG0318	PFAM AMP-dependent synthetase and ligase
SULC_RS01565	COG1960	acyl-CoA dehydrogenase activity
SULC_RS01570	COG1024	Enoyl-CoA hydratase
SULC_RS01575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SULC_RS01580	COG0477	Major facilitator Superfamily
SULC_RS01605	COG0657	acetylesterase activity
SULC_RS01615	COG0318	PFAM AMP-dependent synthetase and ligase
SULC_RS01625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SULC_RS01630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SULC_RS01635	COG0477	Major facilitator Superfamily
SULC_RS01655	COG0432	Pfam Uncharacterised protein family UPF0047
SULC_RS01665	COG1024	Enoyl-CoA hydratase
SULC_RS01675	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SULC_RS01815	COG0477	Major facilitator Superfamily
SULC_RS01820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SULC_RS01825	COG0778	Nitroreductase
SULC_RS01880	COG1489	DNA binding
SULC_RS01900	COG0750	zinc metalloprotease
SULC_RS01935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SULC_RS01940	COG0039	L-malate dehydrogenase activity
SULC_RS01945	COG2079	MmgE PrpD family protein
SULC_RS01950	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SULC_RS01955	COG0517	IMP dehydrogenase activity
SULC_RS01955	COG0516	GMP reductase activity
SULC_RS01960	COG0372	Belongs to the citrate synthase family
SULC_RS01975	COG0149	triose-phosphate isomerase activity
SULC_RS02005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SULC_RS02010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SULC_RS02040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SULC_RS02060	COG0438	transferase activity, transferring glycosyl groups
SULC_RS02075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SULC_RS02080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SULC_RS02090	COG4608	Belongs to the ABC transporter superfamily
SULC_RS02095	COG0444	Belongs to the ABC transporter superfamily
SULC_RS02100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SULC_RS02105	COG0601	transmembrane transport
SULC_RS02130	COG1024	Enoyl-CoA hydratase
SULC_RS02140	COG0183	Belongs to the thiolase family
SULC_RS02225	COG1592	Rubrerythrin
SULC_RS02250	COG4555	ABC transporter
SULC_RS02260	COG2217	Heavy metal translocating P-type atpase
SULC_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
SULC_RS02325	COG4948	Mandelate Racemase Muconate Lactonizing
SULC_RS02365	COG0444	Belongs to the ABC transporter superfamily
SULC_RS02370	COG4608	Belongs to the ABC transporter superfamily
SULC_RS02375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SULC_RS02420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SULC_RS02460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SULC_RS02470	COG2239	Acts as a magnesium transporter
SULC_RS02475	COG1506	peptidase
SULC_RS02475	COG4946	Tricorn protease homolog
SULC_RS02475	COG0823	Involved in the tonB-independent uptake of proteins
SULC_RS02480	COG0501	Belongs to the peptidase M48B family
SULC_RS02485	COG4274	PFAM GYD family protein
SULC_RS02530	COG2814	Major facilitator Superfamily
SULC_RS02535	COG3386	PFAM SMP-30 Gluconolaconase
SULC_RS02540	COG0813	purine-nucleoside phosphorylase activity
SULC_RS02570	COG3842	ATPase activity
SULC_RS02575	COG0395	ABC-type sugar transport system, permease component
SULC_RS02580	COG2814	Major facilitator Superfamily
SULC_RS02585	COG1063	alcohol dehydrogenase
SULC_RS02595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SULC_RS02670	COG1573	uracil-dna glycosylase
SULC_RS02695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SULC_RS02705	COG0517	IMP dehydrogenase activity
SULC_RS02715	COG3387	PFAM Glycoside hydrolase 15-related
SULC_RS02775	COG3387	PFAM Glycoside hydrolase 15-related
SULC_RS02780	COG0438	transferase activity, transferring glycosyl groups
SULC_RS02785	COG1013	pyruvate-flavodoxin oxidoreductase activity
SULC_RS02790	COG0674	pyruvate-flavodoxin oxidoreductase activity
SULC_RS02795	COG1144	Oxidoreductase
SULC_RS02800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SULC_RS02805	COG0437	4 iron, 4 sulfur cluster binding
SULC_RS02820	COG1960	acyl-CoA dehydrogenase activity
SULC_RS02830	COG2086	electron transfer activity
SULC_RS02840	COG0492	ferredoxin-NADP+ reductase activity
SULC_RS02860	COG0668	transmembrane transport
SULC_RS02865	COG0402	S-adenosylhomocysteine deaminase activity
SULC_RS02880	COG3962	Belongs to the TPP enzyme family
SULC_RS02885	COG0438	transferase activity, transferring glycosyl groups
SULC_RS02895	COG0644	oxidoreductase
SULC_RS02905	COG0589	response to stress
SULC_RS02910	COG0656	L-ascorbic acid biosynthetic process
SULC_RS02960	COG0668	transmembrane transport
SULC_RS02965	COG0586	Pfam SNARE associated Golgi protein
SULC_RS02975	COG3511	phospholipase C
SULC_RS03000	COG0437	4 iron, 4 sulfur cluster binding
SULC_RS03005	COG0243	molybdopterin cofactor binding
SULC_RS03030	COG1063	alcohol dehydrogenase
SULC_RS03050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SULC_RS03075	COG0318	PFAM AMP-dependent synthetase and ligase
SULC_RS03110	COG0674	pyruvate-flavodoxin oxidoreductase activity
SULC_RS03110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SULC_RS03115	COG1013	pyruvate-flavodoxin oxidoreductase activity
SULC_RS03120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SULC_RS03125	COG0644	oxidoreductase
SULC_RS03135	COG3848	Pyruvate phosphate dikinase
SULC_RS03135	COG0574	Belongs to the PEP-utilizing enzyme family
SULC_RS03140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SULC_RS03150	COG3383	formate dehydrogenase (NAD+) activity
SULC_RS03190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SULC_RS03240	COG0395	ABC-type sugar transport system, permease component
SULC_RS03245	COG3842	ATPase activity
SULC_RS03250	COG0477	Major facilitator Superfamily
SULC_RS03285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SULC_RS03290	COG1584	GPR1 FUN34 yaaH family protein
SULC_RS03315	COG0281	malic enzyme
SULC_RS03325	COG1250	3-hydroxyacyl-CoA dehydrogenase
SULC_RS03340	COG0318	PFAM AMP-dependent synthetase and ligase
SULC_RS03345	COG1960	acyl-CoA dehydrogenase activity
SULC_RS03355	COG3608	succinylglutamate desuccinylase aspartoacylase
SULC_RS03355	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SULC_RS03405	COG2217	Heavy metal translocating P-type atpase
SULC_RS03430	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SULC_RS03430	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SULC_RS03440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SULC_RS03480	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SULC_RS03600	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SULC_RS03615	COG0477	Major facilitator Superfamily
SULC_RS03620	COG3473	Maleate cis-trans isomerase
SULC_RS03630	COG0179	Fumarylacetoacetate (FAA) hydrolase
SULC_RS03700	COG4608	Belongs to the ABC transporter superfamily
SULC_RS03705	COG0444	Belongs to the ABC transporter superfamily
SULC_RS03710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SULC_RS03715	COG0601	transmembrane transport
SULC_RS03765	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SULC_RS03765	COG2857	Cytochrome c1
SULC_RS03780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SULC_RS03800	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SULC_RS03880	COG1914	H( )-stimulated, divalent metal cation uptake system
SULC_RS03885	COG1250	3-hydroxyacyl-CoA dehydrogenase
SULC_RS03890	COG4948	Mandelate Racemase Muconate Lactonizing
SULC_RS03895	COG0459	protein refolding
SULC_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
SULC_RS03925	COG0673	inositol 2-dehydrogenase activity
SULC_RS03945	COG1132	(ABC) transporter
SULC_RS03955	COG0667	Aldo Keto reductase
SULC_RS03980	COG2723	6-phospho-beta-galactosidase activity
SULC_RS03990	COG1501	Belongs to the glycosyl hydrolase 31 family
SULC_RS04040	COG1472	Belongs to the glycosyl hydrolase 3 family
SULC_RS04060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SULC_RS04065	COG3250	beta-galactosidase activity
SULC_RS04085	COG3386	PFAM SMP-30 Gluconolaconase
SULC_RS04100	COG4608	Belongs to the ABC transporter superfamily
SULC_RS04105	COG0444	Belongs to the ABC transporter superfamily
SULC_RS04110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SULC_RS04120	COG0673	inositol 2-dehydrogenase activity
SULC_RS04150	COG0667	Aldo Keto reductase
SULC_RS04155	COG4608	Belongs to the ABC transporter superfamily
SULC_RS04205	COG0318	PFAM AMP-dependent synthetase and ligase
SULC_RS04220	COG0395	ABC-type sugar transport system, permease component
SULC_RS04225	COG3842	ATPase activity
SULC_RS04235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SULC_RS04305	COG1136	(ABC) transporter
SULC_RS04325	COG0425	Belongs to the sulfur carrier protein TusA family
SULC_RS04365	COG1122	ATPase activity
SULC_RS04410	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SULC_RS04425	COG0805	protein transport
SULC_RS04455	COG1028	Short-chain dehydrogenase reductase Sdr
SULC_RS04465	COG2267	carboxylic ester hydrolase activity
SULC_RS04475	COG0179	Fumarylacetoacetate (FAA) hydrolase
SULC_RS04480	COG2271	Major facilitator Superfamily
SULC_RS04495	COG4948	Mandelate Racemase Muconate Lactonizing
SULC_RS04520	COG2814	Major facilitator Superfamily
SULC_RS04525	COG1139	Iron-sulfur cluster binding protein
SULC_RS04535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SULC_RS04550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SULC_RS04580	COG2271	Major facilitator Superfamily
SULC_RS04610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SULC_RS04645	COG0655	NAD(P)H dehydrogenase (quinone) activity
SULC_RS04660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SULC_RS04665	COG0095	Lipoate-protein ligase
SULC_RS04670	COG0247	lactate metabolic process
SULC_RS04675	COG0277	FAD linked oxidase domain protein
SULC_RS04715	COG1720	tRNA m6t6A37 methyltransferase activity
SULC_RS04730	COG0516	GMP reductase activity
SULC_RS04730	COG0517	IMP dehydrogenase activity
SULC_RS04740	COG1733	regulation of RNA biosynthetic process
SULC_RS04760	COG2814	Major facilitator Superfamily
SULC_RS04770	COG0515	serine threonine protein kinase
SULC_RS04770	COG2815	serine threonine protein kinase
SULC_RS04775	COG0589	response to stress
SULC_RS04780	COG0833	amino acid
SULC_RS04810	COG0243	molybdopterin cofactor binding
SULC_RS04815	COG0530	calcium, potassium:sodium antiporter activity
SULC_RS04820	COG1012	belongs to the aldehyde dehydrogenase family
SULC_RS04830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SULC_RS04835	COG4948	Mandelate Racemase Muconate Lactonizing
SULC_RS04850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SULC_RS04860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SULC_RS04865	COG1063	alcohol dehydrogenase
SULC_RS04870	COG0517	IMP dehydrogenase activity
SULC_RS04870	COG0516	GMP reductase activity
SULC_RS04890	COG0656	L-ascorbic acid biosynthetic process
SULC_RS04905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SULC_RS04920	COG1444	tRNA N-acetyltransferase activity
SULC_RS04935	COG0405	Gamma-glutamyltransferase
SULC_RS04970	COG1830	Aldolase
SULC_RS04980	COG0517	IMP dehydrogenase activity
SULC_RS04980	COG0516	GMP reductase activity
SULC_RS04985	COG0501	Belongs to the peptidase M48B family
SULC_RS04990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SULC_RS04990	COG0519	Catalyzes the synthesis of GMP from XMP
SULC_RS05000	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SULC_RS05010	COG1063	alcohol dehydrogenase
SULC_RS05030	COG0463	Glycosyl transferase, family 2
SULC_RS05080	COG1215	transferase activity, transferring glycosyl groups
SULC_RS05090	COG0351	phosphomethylpyrimidine kinase
SULC_RS05090	COG0352	thiamine-phosphate diphosphorylase activity
SULC_RS05095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SULC_RS05115	COG0123	including yeast histone deacetylase and acetoin utilization protein
SULC_RS05130	COG2860	membrane
SULC_RS05155	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SULC_RS05165	COG1201	RNA secondary structure unwinding
SULC_RS05210	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SULC_RS05220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SULC_RS05220	COG0617	tRNA 3'-terminal CCA addition
SULC_RS05220	COG3620	sequence-specific DNA binding
SULC_RS05240	COG1192	Involved in chromosome partitioning
SULC_RS05335	COG1131	(ABC) transporter
SULC_RS05390	COG1304	FMN binding
SULC_RS05405	COG1355	regulation of microtubule-based process
SULC_RS05410	COG0052	Belongs to the universal ribosomal protein uS2 family
SULC_RS05420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SULC_RS05425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SULC_RS05430	COG0200	Binds to the 23S rRNA
SULC_RS05440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SULC_RS05445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SULC_RS05450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SULC_RS05465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SULC_RS05480	COG0456	acetyltransferase
SULC_RS05480	COG1214	PFAM Peptidase M22, glycoprotease
SULC_RS05505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SULC_RS05510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SULC_RS05520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SULC_RS05525	COG0561	phosphatase activity
SULC_RS05530	COG1078	dGTPase activity
SULC_RS05555	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SULC_RS05570	COG2267	carboxylic ester hydrolase activity
SULC_RS05575	COG1058	Belongs to the CinA family
SULC_RS05575	COG1546	Belongs to the CinA family
SULC_RS05580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SULC_RS05605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SULC_RS05605	COG0517	IMP dehydrogenase activity
SULC_RS05605	COG0617	tRNA 3'-terminal CCA addition
SULC_RS05610	COG1201	RNA secondary structure unwinding
SULC_RS05625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SULC_RS05680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SULC_RS05785	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SULC_RS05830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SULC_RS05835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SULC_RS05850	COG0189	ligase activity
SULC_RS05855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SULC_RS05860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SULC_RS05865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SULC_RS05890	COG1129	ABC transporter
SULC_RS05905	COG0028	Belongs to the TPP enzyme family
SULC_RS05920	COG0017	Asparaginyl-tRNA synthetase
SULC_RS05925	COG0585	pseudouridine synthase activity
SULC_RS05945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SULC_RS05960	COG1648	precorrin-2 dehydrogenase activity
SULC_RS05960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SULC_RS05965	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SULC_RS05970	COG0113	porphobilinogen synthase activity
SULC_RS05975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SULC_RS05980	COG0181	hydroxymethylbilane synthase activity
SULC_RS06005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SULC_RS06015	COG1793	dna ligase
SULC_RS06020	COG0717	Belongs to the dCTP deaminase family
SULC_RS06065	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SULC_RS06080	COG0504	CTP synthase activity
SULC_RS06085	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SULC_RS06105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SULC_RS06115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SULC_RS06120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SULC_RS06160	COG0051	transcription antitermination factor activity, RNA binding
SULC_RS06165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SULC_RS06170	COG0049	tRNA binding
SULC_RS06195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SULC_RS06200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SULC_RS06205	COG0085	RNA polymerase activity
SULC_RS06235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SULC_RS06240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SULC_RS06255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SULC_RS06270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SULC_RS06285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SULC_RS06300	COG0077	Prephenate dehydratase
SULC_RS06300	COG1605	Chorismate mutase
SULC_RS06325	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SULC_RS06325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SULC_RS06340	COG1056	cytidyltransferase-related domain
SULC_RS06340	COG1051	belongs to the nudix hydrolase family
SULC_RS06375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SULC_RS06415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SULC_RS06425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SULC_RS06440	COG0343	queuine tRNA-ribosyltransferase activity
SULC_RS06460	COG0124	histidyl-tRNA synthetase
SULC_RS06475	COG0459	protein refolding
SULC_RS06500	COG1980	fructose-bisphosphate aldolase activity
SULC_RS06505	COG1121	(ABC) transporter
SULC_RS06515	COG0477	Major facilitator Superfamily
SULC_RS06540	COG1185	polyribonucleotide nucleotidyltransferase activity
SULC_RS06550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SULC_RS06570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SULC_RS06575	COG3959	Transketolase, thiamine diphosphate binding domain
SULC_RS06580	COG3958	Transketolase
SULC_RS06585	COG1605	Chorismate mutase
SULC_RS06585	COG0077	Prephenate dehydratase
SULC_RS06590	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SULC_RS06595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SULC_RS06600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SULC_RS06605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SULC_RS06615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SULC_RS06635	COG1199	ATP-dependent helicase activity
SULC_RS06655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SULC_RS06660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SULC_RS06690	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SULC_RS06695	COG0649	NAD binding
SULC_RS06700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SULC_RS06705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SULC_RS06715	COG0713	ATP synthesis coupled electron transport
SULC_RS06720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SULC_RS06725	COG1007	ATP synthesis coupled electron transport
SULC_RS06730	COG1260	myo-inositol-1-phosphate synthase
SULC_RS06735	COG0301	tRNA thio-modification
SULC_RS06765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SULC_RS06775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SULC_RS06785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SULC_RS06800	COG0552	protein localization to endoplasmic reticulum
SULC_RS06865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SULC_RS06880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SULC_RS06890	COG0302	gtp cyclohydrolase
SULC_RS06910	COG3118	belongs to the thioredoxin family
SULC_RS06915	COG0318	PFAM AMP-dependent synthetase and ligase
SULC_RS06930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SULC_RS06935	COG0535	radical SAM domain protein
SULC_RS06975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SULC_RS06990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SULC_RS06995	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SULC_RS07015	COG0438	transferase activity, transferring glycosyl groups
SULC_RS07040	COG1444	tRNA N-acetyltransferase activity
SULC_RS07050	COG2813	Specifically methylates the guanine in position
SULC_RS07055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SULC_RS07060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SULC_RS07070	COG1201	RNA secondary structure unwinding
SULC_RS07090	COG0402	S-adenosylhomocysteine deaminase activity
SULC_RS07100	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SULC_RS07120	COG1797	cobyrinic acid a,c-diamide synthase activity
SULC_RS07135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SULC_RS07165	COG0539	negative regulation of cytoplasmic translation
SULC_RS07180	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SULC_RS07185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SULC_RS07190	COG1110	DNA topoisomerase II activity
SULC_RS07215	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SULC_RS07235	COG0667	Aldo Keto reductase
SULC_RS07240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SULC_RS07250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SULC_RS07260	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SULC_RS07265	COG0163	prenyltransferase activity
SULC_RS07295	COG0423	glycine-tRNA ligase activity
SULC_RS07300	COG0010	Belongs to the arginase family
SULC_RS07335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SULC_RS07345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SULC_RS07375	COG1280	lysine exporter protein (LysE YggA)
SULC_RS07395	COG0489	protein tyrosine kinase activity
SULC_RS07435	COG1992	Thiamine-phosphate synthase
SULC_RS07435	COG0351	phosphomethylpyrimidine kinase
SULC_RS07455	COG3276	selenocysteine insertion sequence binding
SULC_RS07465	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SULC_RS07470	COG0556	nucleotide-excision repair
SULC_RS07480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SULC_RS07500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SULC_RS07505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SULC_RS07515	COG0805	protein transport
SULC_RS07525	COG4139	cobalamin transport
SULC_RS07530	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SULC_RS07535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SULC_RS07550	COG0581	inorganic phosphate transmembrane transporter activity
SULC_RS07575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SULC_RS07625	COG0495	leucyl-tRNA aminoacylation
SULC_RS07930	COG0433	COG0433 Predicted ATPase
SULC_RS08030	COG4974	Belongs to the 'phage' integrase family
SULC_RS08080	COG0535	radical SAM domain protein
SULC_RS08095	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SULC_RS08145	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SULC_RS08150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SULC_RS08170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SULC_RS08175	COG0589	response to stress
SULC_RS08185	COG0126	phosphoglycerate kinase activity
SULC_RS08195	COG0668	transmembrane transport
SULC_RS08220	COG0417	DNA replication proofreading
SULC_RS08250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SULC_RS08270	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SULC_RS08280	COG1394	ATPase activity, coupled to movement of substances
SULC_RS08295	COG0442	prolyl-tRNA aminoacylation
SULC_RS08305	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SULC_RS08310	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SULC_RS08325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SULC_RS08335	COG0028	Belongs to the TPP enzyme family
SULC_RS08345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SULC_RS08355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SULC_RS08370	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SULC_RS08380	COG0037	tRNA processing
SULC_RS08385	COG2096	Adenosyltransferase
SULC_RS08390	COG0495	leucyl-tRNA aminoacylation
SULC_RS08400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SULC_RS08405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SULC_RS08410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SULC_RS08415	COG0131	Imidazoleglycerol-phosphate dehydratase
SULC_RS08420	COG0107	imidazoleglycerol-phosphate synthase activity
SULC_RS08425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SULC_RS08430	COG0140	phosphoribosyl-ATP diphosphatase activity
SULC_RS08430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SULC_RS08435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SULC_RS08445	COG2151	metal-sulfur cluster biosynthetic enzyme
SULC_RS08450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SULC_RS08455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SULC_RS08470	COG1522	sequence-specific DNA binding
SULC_RS08475	COG2095	MarC family integral membrane protein
SULC_RS08490	COG0167	dihydroorotate dehydrogenase activity
SULC_RS08505	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
SULC_RS08515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SULC_RS08555	COG0602	queuosine metabolic process
SULC_RS08560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SULC_RS08565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SULC_RS08565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SULC_RS08570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SULC_RS08580	COG0047	phosphoribosylformylglycinamidine synthase activity
SULC_RS08585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SULC_RS08590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SULC_RS08595	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SULC_RS08605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SULC_RS08620	COG0137	argininosuccinate synthase activity
SULC_RS08625	COG0165	Argininosuccinate lyase
SULC_RS08640	COG0189	ligase activity
SULC_RS08650	COG1250	3-hydroxyacyl-CoA dehydrogenase
SULC_RS08680	COG1024	Enoyl-CoA hydratase
SULC_RS08695	COG0460	homoserine dehydrogenase
SULC_RS08705	COG0864	Transcriptional regulator
SULC_RS08710	COG0312	modulator of DNA gyrase
SULC_RS08715	COG0312	modulator of DNA gyrase
SULC_RS08720	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SULC_RS08720	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SULC_RS08725	COG0009	L-threonylcarbamoyladenylate synthase
SULC_RS08730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SULC_RS08735	COG2379	hydroxypyruvate reductase
SULC_RS08745	COG1321	iron dependent repressor
SULC_RS08775	COG1763	Mo-molybdopterin cofactor biosynthetic process
SULC_RS08780	COG0303	'Molybdopterin
SULC_RS08795	COG0402	S-adenosylhomocysteine deaminase activity
SULC_RS08810	COG0067	glutamate synthase
SULC_RS08815	COG0069	glutamate synthase activity
SULC_RS08825	COG1136	(ABC) transporter
SULC_RS08825	COG0577	efflux transmembrane transporter activity
SULC_RS08835	COG1136	(ABC) transporter
SULC_RS08900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SULC_RS08920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SULC_RS08925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SULC_RS08935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SULC_RS08945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SULC_RS08950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SULC_RS08955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SULC_RS08965	COG0255	Belongs to the universal ribosomal protein uL29 family
SULC_RS08970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SULC_RS08975	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SULC_RS08980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SULC_RS08985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SULC_RS09000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SULC_RS09015	COG0473	3-isopropylmalate dehydrogenase activity
SULC_RS09035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SULC_RS09040	COG0322	excinuclease ABC activity
SULC_RS09070	COG1185	polyribonucleotide nucleotidyltransferase activity
SULC_RS09115	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SULC_RS09125	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SULC_RS09130	COG2264	protein methyltransferase activity
SULC_RS09135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SULC_RS09170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SULC_RS09185	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SULC_RS09200	COG1047	Peptidyl-prolyl cis-trans
SULC_RS09205	COG0371	Dehydrogenase
SULC_RS09210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SULC_RS09245	COG1063	alcohol dehydrogenase
SULC_RS09250	COG0154	amidase activity
SULC_RS09255	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SULC_RS09260	COG1881	PFAM PEBP family protein
SULC_RS09270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SULC_RS09275	COG0315	cyclic pyranopterin monophosphate synthase activity
SULC_RS09320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SULC_RS09335	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SULC_RS09390	COG0459	protein refolding
SULC_RS09425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SULC_RS09445	COG0460	homoserine dehydrogenase
SULC_RS09445	COG0527	aspartate kinase activity
SULC_RS09450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SULC_RS09470	COG0574	Belongs to the PEP-utilizing enzyme family
SULC_RS09470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SULC_RS09475	COG1260	myo-inositol-1-phosphate synthase
SULC_RS09480	COG1254	Belongs to the acylphosphatase family
SULC_RS09485	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SULC_RS09490	COG0159	tryptophan synthase activity
SULC_RS09500	COG0135	phosphoribosylanthranilate isomerase activity
SULC_RS09505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SULC_RS09510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SULC_RS09510	COG0512	Glutamine amidotransferase of anthranilate synthase
SULC_RS09520	COG0436	Aminotransferase
SULC_RS09525	COG0525	valine-tRNA ligase activity
SULC_RS09530	COG0644	oxidoreductase
SULC_RS09560	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
SULC_RS09565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SULC_RS09580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SULC_RS09585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SULC_RS09605	COG0148	phosphopyruvate hydratase activity
SULC_RS09625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SULC_RS09635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SULC_RS09640	COG0509	glycine decarboxylation via glycine cleavage system
SULC_RS09660	COG0396	ATPase activity
SULC_RS09665	COG0719	Fe-S assembly protein
SULC_RS09670	COG0719	Fe-S assembly protein
SULC_RS09670	COG1372	Participates in initiation and elongation during chromosome replication
SULC_RS09685	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SULC_RS09700	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SULC_RS09705	COG0252	asparaginase activity
SULC_RS09735	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
SULC_RS09790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SULC_RS09790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SULC_RS09805	COG0154	amidase activity
SULC_RS09845	COG1110	DNA topoisomerase II activity
SULC_RS09875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SULC_RS09885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SULC_RS09890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SULC_RS09905	COG1028	Short-chain dehydrogenase reductase Sdr
SULC_RS09915	COG0528	UMP kinase activity
SULC_RS09925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SULC_RS09945	COG0469	pyruvate kinase activity
SULC_RS09955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SULC_RS09965	COG0297	glycogen (starch) synthase activity
SULC_RS09975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SULC_RS10005	COG0157	Belongs to the NadC ModD family
SULC_RS10010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SULC_RS10015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SULC_RS10030	COG0395	ABC-type sugar transport system, permease component
SULC_RS10050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SULC_RS10065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SULC_RS10070	COG0028	Belongs to the TPP enzyme family
SULC_RS10085	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SULC_RS10090	COG2897	thiosulfate sulfurtransferase activity
SULC_RS10100	COG0651	ATP synthesis coupled electron transport
SULC_RS10105	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SULC_RS10110	COG0649	NAD binding
SULC_RS10115	COG0651	ATP synthesis coupled electron transport
SULC_RS10125	COG0650	Formate hydrogenlyase subunit 4
SULC_RS10140	COG3383	formate dehydrogenase (NAD+) activity
SULC_RS10145	COG0300	oxidoreductase activity
SULC_RS10150	COG0725	ABC transporter, periplasmic molybdate-binding protein
SULC_RS10155	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SULC_RS10200	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SULC_RS10215	COG1234	tRNA 3'-trailer cleavage
SULC_RS10260	COG1185	polyribonucleotide nucleotidyltransferase activity
SULC_RS10275	COG0004	ammonium transporteR
SULC_RS10310	COG0095	Lipoate-protein ligase
SULC_RS10315	COG0509	glycine decarboxylation via glycine cleavage system
SULC_RS10335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SULC_RS10340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SULC_RS10345	COG2005	Transcriptional regulator
SULC_RS10360	COG0531	amino acid
SULC_RS10390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SULC_RS10390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SULC_RS10395	COG0517	IMP dehydrogenase activity
SULC_RS10405	COG0114	fumarate hydratase activity
SULC_RS10410	COG1136	(ABC) transporter
SULC_RS10425	COG1846	Transcriptional regulator
SULC_RS10430	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SULC_RS10435	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SULC_RS10480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SULC_RS10520	COG2271	Major facilitator Superfamily
SULC_RS10530	COG0509	glycine decarboxylation via glycine cleavage system
SULC_RS10560	COG1832	CoA-binding protein
SULC_RS10565	COG0095	Lipoate-protein ligase
SULC_RS10610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SULC_RS10620	COG2210	Belongs to the sulfur carrier protein TusA family
SULC_RS10625	COG0425	Belongs to the sulfur carrier protein TusA family
SULC_RS10655	COG2048	Heterodisulfide reductase, subunit B
SULC_RS10670	COG0475	glutathione-regulated potassium exporter activity
SULC_RS10700	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SULC_RS10705	COG0477	Major facilitator Superfamily
SULC_RS10745	COG1960	acyl-CoA dehydrogenase activity
SULC_RS10785	COG2814	Major facilitator Superfamily
SULC_RS10805	COG3842	ATPase activity
SULC_RS10810	COG3833	ABC-type maltose transport systems, permease component
SULC_RS10815	COG1175	transmembrane transport
SULC_RS10850	COG0436	Aminotransferase
SULC_RS10885	COG2271	Major facilitator Superfamily
SULC_RS10890	COG1335	isochorismatase
SULC_RS10935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SULC_RS10940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SULC_RS10950	COG2062	phosphohistidine phosphatase, SixA
SULC_RS11000	COG1013	pyruvate-flavodoxin oxidoreductase activity
SULC_RS11005	COG0674	pyruvate-flavodoxin oxidoreductase activity
SULC_RS11040	COG0277	FAD linked oxidase domain protein
SULC_RS11080	COG3608	succinylglutamate desuccinylase aspartoacylase
SULC_RS11080	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SULC_RS11120	COG3350	monooxygenase activity
SULC_RS11145	COG2151	metal-sulfur cluster biosynthetic enzyme
SULC_RS11205	COG2050	protein possibly involved in aromatic compounds catabolism
SULC_RS11205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SULC_RS11210	COG2301	Belongs to the HpcH HpaI aldolase family
SULC_RS11215	COG1802	Transcriptional regulator
SULC_RS11230	COG2721	sulfolactate sulfo-lyase activity
SULC_RS11235	COG2721	sulfolactate sulfo-lyase activity
SULC_RS11255	COG1131	(ABC) transporter
SULC_RS11260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SULC_RS11275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SULC_RS11290	COG0601	transmembrane transport
SULC_RS11300	COG0444	Belongs to the ABC transporter superfamily
SULC_RS11305	COG4608	Belongs to the ABC transporter superfamily
SULC_RS11320	COG4608	Belongs to the ABC transporter superfamily
SULC_RS11325	COG0444	Belongs to the ABC transporter superfamily
SULC_RS11335	COG0601	transmembrane transport
SULC_RS11360	COG1373	ATPase (AAA superfamily
SULC_RS11410	COG1215	transferase activity, transferring glycosyl groups
SULC_RS11440	COG4948	Mandelate Racemase Muconate Lactonizing
SULC_RS11460	COG2814	Major facilitator Superfamily
SULC_RS11550	COG1203	CRISPR-associated helicase, Cas3
SULC_RS11600	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SULC_RS11625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SULC_RS11660	COG0531	amino acid
SULC_RS11670	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SULC_RS11690	COG1373	ATPase (AAA superfamily
SULC_RS11905	COG0813	purine-nucleoside phosphorylase activity
SULC_RS11935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SULC_RS11940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SULC_RS11945	COG0022	dehydrogenase e1 component
SULC_RS11950	COG3199	ATP-NAD kinase
SULC_RS11955	COG0508	dehydrogenase complex catalyzes the overall conversion of
SULC_RS11960	COG0277	FAD linked oxidase domain protein
SULC_RS11965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SULC_RS11970	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SULC_RS11995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SULC_RS12000	COG0477	Major facilitator Superfamily
SULC_RS12055	COG3335	DDE superfamily endonuclease
SULC_RS12075	COG2084	Dehydrogenase
SULC_RS12090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SULC_RS12155	COG0243	molybdopterin cofactor binding
SULC_RS12215	COG1725	Transcriptional regulator
SULC_RS12305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SULC_RS12310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SULC_RS12315	COG4279	zinc finger
SULC_RS12360	COG1953	Uracil, thiamine, allantoin
SULC_RS12495	COG0531	amino acid
SULC_RS12505	COG3335	DDE superfamily endonuclease
SULC_RS12575	COG0438	transferase activity, transferring glycosyl groups
SULC_RS12745	COG1215	transferase activity, transferring glycosyl groups
SULC_RS12750	COG1216	Glycosyl transferase, family 2
SULC_RS12750	COG1442	glycosyl transferase family 8
SULC_RS12760	COG0463	Glycosyl transferase, family 2
SULC_RS12760	COG1216	Glycosyl transferase, family 2
SULC_RS12880	COG2002	toxin-antitoxin pair type II binding
SULC_RS12940	COG0425	Belongs to the sulfur carrier protein TusA family
SULC_RS13115	COG0577	efflux transmembrane transporter activity
SULC_RS13115	COG1136	(ABC) transporter
SULC_RS13170	COG2151	metal-sulfur cluster biosynthetic enzyme
SULC_RS13175	COG0589	response to stress
SULC_RS13195	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SULC_RS13205	COG0501	Belongs to the peptidase M48B family
SULC_RS13215	COG0519	Catalyzes the synthesis of GMP from XMP
SULC_RS13265	COG0535	radical SAM domain protein
SULC_RS13270	COG0535	radical SAM domain protein
SULC_RS13390	COG2897	thiosulfate sulfurtransferase activity
SULC_RS13520	COG0513	Belongs to the DEAD box helicase family
SULC_RS13550	COG1011	Hydrolase
SULC_RS13555	COG4106	trans-aconitate 2-methyltransferase activity
SULC_RS13605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SULC_RS13610	COG1953	Uracil, thiamine, allantoin
SULC_RS13615	COG0531	amino acid
SULC_RS13620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SULC_RS13630	COG2814	Major facilitator Superfamily
SULC_RS13655	COG3384	dioxygenase
SULC_RS13780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SULC_RS13800	COG1131	(ABC) transporter
SULC_RS13825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SULC_RS13830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SULC_RS13880	COG1473	amidohydrolase
SULC_RS13995	COG1960	acyl-CoA dehydrogenase activity
SULC_RS14005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SULC_RS14035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SULC_RS14040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SULC_RS14045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SULC_RS14080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SULC_RS14080	COG2146	nitrite reductase [NAD(P)H] activity
SULC_RS14100	COG0412	Dienelactone hydrolase
SULC_RS14150	COG0793	Belongs to the peptidase S41A family
SULC_RS14150	COG4946	Tricorn protease homolog
SULC_RS14155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SULC_RS14260	COG1121	(ABC) transporter
SULC_RS14275	COG1305	Transglutaminase-like
SULC_RS14280	COG0450	alkyl hydroperoxide reductase
SULC_RS14310	COG1620	l-lactate permease
SULC_RS14335	COG0674	pyruvate-flavodoxin oxidoreductase activity
SULC_RS14340	COG1013	pyruvate-flavodoxin oxidoreductase activity
SULC_RS14345	COG1522	sequence-specific DNA binding
SULC_RS14360	COG0477	Major facilitator Superfamily
SULC_RS14370	COG1131	(ABC) transporter
SULC_RS14465	COG0561	phosphatase activity
SULC_RS14475	COG1011	Hydrolase
SULC_RS14490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SULC_RS14525	COG0494	nUDIX hydrolase
SULC_RS14535	COG3253	May function as heme-dependent peroxidase
SULC_RS14550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SULC_RS14555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SULC_RS14555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SULC_RS14585	COG2226	methyltransferase