locus-tag	class	description
SSO_RS00005	COG1215	transferase activity, transferring glycosyl groups
SSO_RS00015	COG0352	thiamine-phosphate diphosphorylase activity
SSO_RS00015	COG0351	phosphomethylpyrimidine kinase
SSO_RS00020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SSO_RS00040	COG0123	including yeast histone deacetylase and acetoin utilization protein
SSO_RS00055	COG2860	membrane
SSO_RS00080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SSO_RS00090	COG1201	RNA secondary structure unwinding
SSO_RS00135	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SSO_RS00145	COG0617	tRNA 3'-terminal CCA addition
SSO_RS00145	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SSO_RS00145	COG3620	sequence-specific DNA binding
SSO_RS00165	COG1192	Involved in chromosome partitioning
SSO_RS00260	COG1131	(ABC) transporter
SSO_RS00315	COG1304	FMN binding
SSO_RS00330	COG1355	regulation of microtubule-based process
SSO_RS00335	COG0052	Belongs to the universal ribosomal protein uS2 family
SSO_RS00345	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SSO_RS00350	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SSO_RS00355	COG0200	Binds to the 23S rRNA
SSO_RS00365	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SSO_RS00370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SSO_RS00375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SSO_RS00390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SSO_RS00405	COG1214	PFAM Peptidase M22, glycoprotease
SSO_RS00405	COG0456	acetyltransferase
SSO_RS00430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SSO_RS00435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SSO_RS00450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SSO_RS00455	COG0561	phosphatase activity
SSO_RS00460	COG1078	dGTPase activity
SSO_RS00485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SSO_RS00500	COG2267	carboxylic ester hydrolase activity
SSO_RS00505	COG1546	Belongs to the CinA family
SSO_RS00505	COG1058	Belongs to the CinA family
SSO_RS00510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SSO_RS00535	COG0617	tRNA 3'-terminal CCA addition
SSO_RS00535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SSO_RS00535	COG0517	IMP dehydrogenase activity
SSO_RS00540	COG1201	RNA secondary structure unwinding
SSO_RS00555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SSO_RS00610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SSO_RS00710	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SSO_RS00755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SSO_RS00760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SSO_RS00775	COG0189	ligase activity
SSO_RS00780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SSO_RS00785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SSO_RS00790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SSO_RS00815	COG1129	ABC transporter
SSO_RS00830	COG0028	Belongs to the TPP enzyme family
SSO_RS00845	COG0017	Asparaginyl-tRNA synthetase
SSO_RS00850	COG0585	pseudouridine synthase activity
SSO_RS00870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SSO_RS00885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SSO_RS00885	COG1648	precorrin-2 dehydrogenase activity
SSO_RS00890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SSO_RS00895	COG0113	porphobilinogen synthase activity
SSO_RS00900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SSO_RS00905	COG0181	hydroxymethylbilane synthase activity
SSO_RS00930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SSO_RS00940	COG1793	dna ligase
SSO_RS00945	COG0717	Belongs to the dCTP deaminase family
SSO_RS00990	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SSO_RS01005	COG0504	CTP synthase activity
SSO_RS01010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SSO_RS01030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SSO_RS01040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SSO_RS01045	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SSO_RS01085	COG0051	transcription antitermination factor activity, RNA binding
SSO_RS01090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SSO_RS01095	COG0049	tRNA binding
SSO_RS01120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SSO_RS01125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SSO_RS01155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SSO_RS01160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SSO_RS01175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SSO_RS01190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SSO_RS01205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SSO_RS01220	COG1605	Chorismate mutase
SSO_RS01220	COG0077	Prephenate dehydratase
SSO_RS01245	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SSO_RS01245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SSO_RS01260	COG1056	cytidyltransferase-related domain
SSO_RS01260	COG1051	belongs to the nudix hydrolase family
SSO_RS01295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SSO_RS01335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SSO_RS01345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SSO_RS01360	COG0343	queuine tRNA-ribosyltransferase activity
SSO_RS01380	COG0124	histidyl-tRNA synthetase
SSO_RS01395	COG0459	protein refolding
SSO_RS01420	COG1980	fructose-bisphosphate aldolase activity
SSO_RS01425	COG1121	(ABC) transporter
SSO_RS01435	COG0477	Major facilitator Superfamily
SSO_RS01460	COG1185	polyribonucleotide nucleotidyltransferase activity
SSO_RS01470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SSO_RS01490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SSO_RS01495	COG3959	Transketolase, thiamine diphosphate binding domain
SSO_RS01500	COG3958	Transketolase
SSO_RS01505	COG1605	Chorismate mutase
SSO_RS01505	COG0077	Prephenate dehydratase
SSO_RS01510	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SSO_RS01515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SSO_RS01520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SSO_RS01525	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SSO_RS01535	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SSO_RS01555	COG1199	ATP-dependent helicase activity
SSO_RS01575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SSO_RS01580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SSO_RS01610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SSO_RS01615	COG0649	NAD binding
SSO_RS01620	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SSO_RS01625	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SSO_RS01635	COG0713	ATP synthesis coupled electron transport
SSO_RS01640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SSO_RS01645	COG1007	ATP synthesis coupled electron transport
SSO_RS01650	COG1260	myo-inositol-1-phosphate synthase
SSO_RS01655	COG0301	tRNA thio-modification
SSO_RS01685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SSO_RS01695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SSO_RS01705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SSO_RS01720	COG0552	protein localization to endoplasmic reticulum
SSO_RS01785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SSO_RS01800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SSO_RS01810	COG0302	gtp cyclohydrolase
SSO_RS01830	COG3118	belongs to the thioredoxin family
SSO_RS01835	COG0318	PFAM AMP-dependent synthetase and ligase
SSO_RS01850	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SSO_RS01855	COG0535	radical SAM domain protein
SSO_RS01865	COG0475	glutathione-regulated potassium exporter activity
SSO_RS01890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SSO_RS01900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SSO_RS01905	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SSO_RS01925	COG0438	transferase activity, transferring glycosyl groups
SSO_RS01950	COG1444	tRNA N-acetyltransferase activity
SSO_RS01960	COG2813	Specifically methylates the guanine in position
SSO_RS01965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SSO_RS01970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SSO_RS01980	COG1201	RNA secondary structure unwinding
SSO_RS02000	COG0402	S-adenosylhomocysteine deaminase activity
SSO_RS02010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SSO_RS02030	COG1797	cobyrinic acid a,c-diamide synthase activity
SSO_RS02045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SSO_RS02075	COG0539	negative regulation of cytoplasmic translation
SSO_RS02090	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SSO_RS02095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SSO_RS02100	COG1110	DNA topoisomerase II activity
SSO_RS02125	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SSO_RS02145	COG0667	Aldo Keto reductase
SSO_RS02150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SSO_RS02175	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SSO_RS02180	COG0163	prenyltransferase activity
SSO_RS02210	COG0423	glycine-tRNA ligase activity
SSO_RS02215	COG0010	Belongs to the arginase family
SSO_RS02245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SSO_RS02255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SSO_RS02285	COG1280	lysine exporter protein (LysE YggA)
SSO_RS02305	COG0489	protein tyrosine kinase activity
SSO_RS02335	COG1992	Thiamine-phosphate synthase
SSO_RS02335	COG0351	phosphomethylpyrimidine kinase
SSO_RS02355	COG3276	selenocysteine insertion sequence binding
SSO_RS02365	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SSO_RS02370	COG0556	nucleotide-excision repair
SSO_RS02380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SSO_RS02405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SSO_RS02415	COG0805	protein transport
SSO_RS02430	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SSO_RS02435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SSO_RS02450	COG0581	inorganic phosphate transmembrane transporter activity
SSO_RS02465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SSO_RS02515	COG0495	leucyl-tRNA aminoacylation
SSO_RS02650	COG0126	phosphoglycerate kinase activity
SSO_RS02660	COG0589	response to stress
SSO_RS02665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SSO_RS02685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SSO_RS02690	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SSO_RS02745	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SSO_RS02765	COG0535	radical SAM domain protein
SSO_RS02795	COG0668	transmembrane transport
SSO_RS02815	COG0417	DNA replication proofreading
SSO_RS02845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSO_RS02865	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SSO_RS02875	COG1394	ATPase activity, coupled to movement of substances
SSO_RS02890	COG0442	prolyl-tRNA aminoacylation
SSO_RS02900	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SSO_RS02905	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SSO_RS02920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SSO_RS02930	COG0028	Belongs to the TPP enzyme family
SSO_RS02940	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SSO_RS02950	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SSO_RS02965	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SSO_RS02975	COG0037	tRNA processing
SSO_RS02980	COG2096	Adenosyltransferase
SSO_RS02985	COG0495	leucyl-tRNA aminoacylation
SSO_RS02995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SSO_RS03000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SSO_RS03005	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SSO_RS03010	COG0131	Imidazoleglycerol-phosphate dehydratase
SSO_RS03015	COG0107	imidazoleglycerol-phosphate synthase activity
SSO_RS03020	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SSO_RS03025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SSO_RS03025	COG0140	phosphoribosyl-ATP diphosphatase activity
SSO_RS03030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SSO_RS03040	COG2151	metal-sulfur cluster biosynthetic enzyme
SSO_RS03045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SSO_RS03050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SSO_RS03065	COG1522	sequence-specific DNA binding
SSO_RS03070	COG2095	MarC family integral membrane protein
SSO_RS03085	COG0167	dihydroorotate dehydrogenase activity
SSO_RS03100	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
SSO_RS03110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SSO_RS03150	COG0602	queuosine metabolic process
SSO_RS03155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SSO_RS03160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSO_RS03160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSO_RS03165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SSO_RS03175	COG0047	phosphoribosylformylglycinamidine synthase activity
SSO_RS03180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SSO_RS03185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SSO_RS03190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SSO_RS03200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SSO_RS03215	COG0137	argininosuccinate synthase activity
SSO_RS03220	COG0165	Argininosuccinate lyase
SSO_RS03235	COG0189	ligase activity
SSO_RS03245	COG1250	3-hydroxyacyl-CoA dehydrogenase
SSO_RS03275	COG1024	Enoyl-CoA hydratase
SSO_RS03290	COG0460	homoserine dehydrogenase
SSO_RS03300	COG0864	Transcriptional regulator
SSO_RS03305	COG0312	modulator of DNA gyrase
SSO_RS03310	COG0312	modulator of DNA gyrase
SSO_RS03315	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SSO_RS03315	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SSO_RS03320	COG0009	L-threonylcarbamoyladenylate synthase
SSO_RS03325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SSO_RS03330	COG2379	hydroxypyruvate reductase
SSO_RS03340	COG1321	iron dependent repressor
SSO_RS03370	COG1763	Mo-molybdopterin cofactor biosynthetic process
SSO_RS03375	COG0303	'Molybdopterin
SSO_RS03390	COG0402	S-adenosylhomocysteine deaminase activity
SSO_RS03405	COG0067	glutamate synthase
SSO_RS03410	COG0069	glutamate synthase activity
SSO_RS03420	COG1136	(ABC) transporter
SSO_RS03420	COG0577	efflux transmembrane transporter activity
SSO_RS03430	COG1136	(ABC) transporter
SSO_RS03495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SSO_RS03515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SSO_RS03520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SSO_RS03530	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SSO_RS03540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SSO_RS03545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SSO_RS03550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SSO_RS03560	COG0255	Belongs to the universal ribosomal protein uL29 family
SSO_RS03565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SSO_RS03570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SSO_RS03575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SSO_RS03580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SSO_RS03595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SSO_RS03610	COG0473	3-isopropylmalate dehydrogenase activity
SSO_RS03630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SSO_RS03635	COG0322	excinuclease ABC activity
SSO_RS03665	COG1185	polyribonucleotide nucleotidyltransferase activity
SSO_RS03710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SSO_RS03720	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SSO_RS03725	COG2264	protein methyltransferase activity
SSO_RS03730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SSO_RS03765	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SSO_RS03780	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SSO_RS03795	COG1047	Peptidyl-prolyl cis-trans
SSO_RS03800	COG0371	Dehydrogenase
SSO_RS03805	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SSO_RS03840	COG1063	alcohol dehydrogenase
SSO_RS03845	COG0154	amidase activity
SSO_RS03850	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SSO_RS03855	COG1881	PFAM PEBP family protein
SSO_RS03865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SSO_RS03870	COG0315	cyclic pyranopterin monophosphate synthase activity
SSO_RS03930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SSO_RS04115	COG1216	Glycosyl transferase, family 2
SSO_RS04125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SSO_RS04130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SSO_RS04135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SSO_RS04145	COG2264	protein methyltransferase activity
SSO_RS04165	COG1215	transferase activity, transferring glycosyl groups
SSO_RS04245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SSO_RS04340	COG0459	protein refolding
SSO_RS04375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SSO_RS04395	COG0527	aspartate kinase activity
SSO_RS04395	COG0460	homoserine dehydrogenase
SSO_RS04400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SSO_RS04420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SSO_RS04420	COG0574	Belongs to the PEP-utilizing enzyme family
SSO_RS04425	COG1260	myo-inositol-1-phosphate synthase
SSO_RS04430	COG1254	Belongs to the acylphosphatase family
SSO_RS04435	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SSO_RS04440	COG0159	tryptophan synthase activity
SSO_RS04450	COG0135	phosphoribosylanthranilate isomerase activity
SSO_RS04455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SSO_RS04460	COG0512	Glutamine amidotransferase of anthranilate synthase
SSO_RS04460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SSO_RS04470	COG0436	Aminotransferase
SSO_RS04475	COG0525	valine-tRNA ligase activity
SSO_RS04480	COG0644	oxidoreductase
SSO_RS04510	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
SSO_RS04515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SSO_RS04530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SSO_RS04535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SSO_RS04555	COG0148	phosphopyruvate hydratase activity
SSO_RS04575	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SSO_RS04585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SSO_RS04590	COG0509	glycine decarboxylation via glycine cleavage system
SSO_RS04615	COG0719	Fe-S assembly protein
SSO_RS04620	COG0719	Fe-S assembly protein
SSO_RS04620	COG1372	Participates in initiation and elongation during chromosome replication
SSO_RS04635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SSO_RS04650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SSO_RS04655	COG0252	asparaginase activity
SSO_RS04685	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
SSO_RS04740	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SSO_RS04740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SSO_RS04755	COG0154	amidase activity
SSO_RS04795	COG1110	DNA topoisomerase II activity
SSO_RS04825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SSO_RS04835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SSO_RS04840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SSO_RS04855	COG1028	Short-chain dehydrogenase reductase Sdr
SSO_RS04865	COG0528	UMP kinase activity
SSO_RS04875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SSO_RS04895	COG0469	pyruvate kinase activity
SSO_RS04905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SSO_RS04915	COG0297	glycogen (starch) synthase activity
SSO_RS04925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SSO_RS04955	COG0157	Belongs to the NadC ModD family
SSO_RS04960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SSO_RS04965	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SSO_RS04980	COG0395	ABC-type sugar transport system, permease component
SSO_RS05000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SSO_RS05015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSO_RS05020	COG0028	Belongs to the TPP enzyme family
SSO_RS05035	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SSO_RS05040	COG2897	thiosulfate sulfurtransferase activity
SSO_RS05050	COG0651	ATP synthesis coupled electron transport
SSO_RS05055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SSO_RS05060	COG0649	NAD binding
SSO_RS05065	COG0651	ATP synthesis coupled electron transport
SSO_RS05075	COG0650	Formate hydrogenlyase subunit 4
SSO_RS05090	COG3383	formate dehydrogenase (NAD+) activity
SSO_RS05095	COG0300	oxidoreductase activity
SSO_RS05100	COG0725	ABC transporter, periplasmic molybdate-binding protein
SSO_RS05105	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SSO_RS05150	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SSO_RS05165	COG1234	tRNA 3'-trailer cleavage
SSO_RS05210	COG1185	polyribonucleotide nucleotidyltransferase activity
SSO_RS05230	COG0004	ammonium transporteR
SSO_RS05265	COG0509	glycine decarboxylation via glycine cleavage system
SSO_RS05285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SSO_RS05290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SSO_RS05295	COG2005	Transcriptional regulator
SSO_RS05305	COG0531	amino acid
SSO_RS05335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SSO_RS05335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SSO_RS05340	COG0517	IMP dehydrogenase activity
SSO_RS05350	COG0114	fumarate hydratase activity
SSO_RS05355	COG1136	(ABC) transporter
SSO_RS05365	COG0577	efflux transmembrane transporter activity
SSO_RS05365	COG1136	(ABC) transporter
SSO_RS05370	COG1846	Transcriptional regulator
SSO_RS05375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SSO_RS05380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SSO_RS05425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SSO_RS05465	COG2271	Major facilitator Superfamily
SSO_RS05475	COG0509	glycine decarboxylation via glycine cleavage system
SSO_RS05505	COG1832	CoA-binding protein
SSO_RS05510	COG0095	Lipoate-protein ligase
SSO_RS05555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSO_RS05565	COG2210	Belongs to the sulfur carrier protein TusA family
SSO_RS05570	COG0425	Belongs to the sulfur carrier protein TusA family
SSO_RS05600	COG2048	Heterodisulfide reductase, subunit B
SSO_RS05615	COG0475	glutathione-regulated potassium exporter activity
SSO_RS05640	COG1131	(ABC) transporter
SSO_RS05645	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SSO_RS05685	COG1960	acyl-CoA dehydrogenase activity
SSO_RS05725	COG2814	Major facilitator Superfamily
SSO_RS05745	COG3842	ATPase activity
SSO_RS05750	COG3833	ABC-type maltose transport systems, permease component
SSO_RS05755	COG1175	transmembrane transport
SSO_RS05790	COG0436	Aminotransferase
SSO_RS05830	COG2271	Major facilitator Superfamily
SSO_RS05835	COG1335	isochorismatase
SSO_RS05875	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SSO_RS05880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SSO_RS05890	COG2062	phosphohistidine phosphatase, SixA
SSO_RS05940	COG1013	pyruvate-flavodoxin oxidoreductase activity
SSO_RS05945	COG0674	pyruvate-flavodoxin oxidoreductase activity
SSO_RS06000	COG1012	belongs to the aldehyde dehydrogenase family
SSO_RS06010	COG1063	alcohol dehydrogenase
SSO_RS06045	COG3350	monooxygenase activity
SSO_RS06070	COG2151	metal-sulfur cluster biosynthetic enzyme
SSO_RS06130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SSO_RS06130	COG2050	protein possibly involved in aromatic compounds catabolism
SSO_RS06135	COG2301	Belongs to the HpcH HpaI aldolase family
SSO_RS06140	COG1802	Transcriptional regulator
SSO_RS06160	COG2721	sulfolactate sulfo-lyase activity
SSO_RS06165	COG2721	sulfolactate sulfo-lyase activity
SSO_RS06200	COG1131	(ABC) transporter
SSO_RS06205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SSO_RS06220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SSO_RS06235	COG0601	transmembrane transport
SSO_RS06245	COG0444	Belongs to the ABC transporter superfamily
SSO_RS06250	COG4608	Belongs to the ABC transporter superfamily
SSO_RS06280	COG0444	Belongs to the ABC transporter superfamily
SSO_RS06290	COG0601	transmembrane transport
SSO_RS06315	COG1373	ATPase (AAA superfamily
SSO_RS06360	COG1215	transferase activity, transferring glycosyl groups
SSO_RS06380	COG4948	Mandelate Racemase Muconate Lactonizing
SSO_RS06385	COG2814	Major facilitator Superfamily
SSO_RS06400	COG0598	Magnesium transport protein CorA
SSO_RS06405	COG2308	Evidence 4 Homologs of previously reported genes of
SSO_RS06410	COG1305	Transglutaminase-like
SSO_RS06420	COG1024	Enoyl-CoA hydratase
SSO_RS06460	COG1131	(ABC) transporter
SSO_RS06475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SSO_RS06480	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SSO_RS06495	COG1401	restriction endodeoxyribonuclease activity
SSO_RS06530	COG2224	Isocitrate lyase
SSO_RS06535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SSO_RS06570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SSO_RS06615	COG2814	Major facilitator Superfamily
SSO_RS06635	COG1473	amidohydrolase
SSO_RS06695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SSO_RS06700	COG0022	dehydrogenase e1 component
SSO_RS06860	COG1203	CRISPR-associated helicase, Cas3
SSO_RS07085	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SSO_RS07090	COG1468	defense response to virus
SSO_RS07090	COG1518	maintenance of DNA repeat elements
SSO_RS07110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SSO_RS07145	COG0531	amino acid
SSO_RS07155	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SSO_RS07175	COG1373	ATPase (AAA superfamily
SSO_RS07330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SSO_RS07405	COG0813	purine-nucleoside phosphorylase activity
SSO_RS07435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSO_RS07440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SSO_RS07445	COG0022	dehydrogenase e1 component
SSO_RS07450	COG3199	ATP-NAD kinase
SSO_RS07460	COG0277	FAD linked oxidase domain protein
SSO_RS07465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SSO_RS07470	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SSO_RS07490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SSO_RS07495	COG0477	Major facilitator Superfamily
SSO_RS07570	COG2084	Dehydrogenase
SSO_RS07585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSO_RS07655	COG0243	molybdopterin cofactor binding
SSO_RS07695	COG1725	Transcriptional regulator
SSO_RS07725	COG0318	PFAM AMP-dependent synthetase and ligase
SSO_RS07730	COG1960	acyl-CoA dehydrogenase activity
SSO_RS07745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SSO_RS07780	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SSO_RS07875	COG2264	protein methyltransferase activity
SSO_RS07900	COG1012	belongs to the aldehyde dehydrogenase family
SSO_RS07905	COG0535	radical SAM domain protein
SSO_RS07910	COG0535	radical SAM domain protein
SSO_RS08030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SSO_RS08035	COG4279	zinc finger
SSO_RS08080	COG1953	Uracil, thiamine, allantoin
SSO_RS08210	COG0531	amino acid
SSO_RS08220	COG3335	DDE superfamily endonuclease
SSO_RS08415	COG2002	toxin-antitoxin pair type II binding
SSO_RS08490	COG0425	Belongs to the sulfur carrier protein TusA family
SSO_RS08750	COG1136	(ABC) transporter
SSO_RS08750	COG0577	efflux transmembrane transporter activity
SSO_RS08795	COG2897	thiosulfate sulfurtransferase activity
SSO_RS08825	COG1078	dGTPase activity
SSO_RS08895	COG0535	radical SAM domain protein
SSO_RS08900	COG0535	radical SAM domain protein
SSO_RS08905	COG1012	belongs to the aldehyde dehydrogenase family
SSO_RS08945	COG0519	Catalyzes the synthesis of GMP from XMP
SSO_RS08955	COG0501	Belongs to the peptidase M48B family
SSO_RS08965	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SSO_RS08980	COG0589	response to stress
SSO_RS08985	COG2151	metal-sulfur cluster biosynthetic enzyme
SSO_RS09115	COG0513	Belongs to the DEAD box helicase family
SSO_RS09145	COG1011	Hydrolase
SSO_RS09160	COG4106	trans-aconitate 2-methyltransferase activity
SSO_RS09205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SSO_RS09215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SSO_RS09220	COG1953	Uracil, thiamine, allantoin
SSO_RS09225	COG0531	amino acid
SSO_RS09230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SSO_RS09240	COG2814	Major facilitator Superfamily
SSO_RS09265	COG3384	dioxygenase
SSO_RS09395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SSO_RS09415	COG1131	(ABC) transporter
SSO_RS09445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SSO_RS09450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SSO_RS09500	COG1473	amidohydrolase
SSO_RS09625	COG0393	Putative heavy-metal-binding
SSO_RS09720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SSO_RS09745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SSO_RS09785	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SSO_RS09815	COG0425	Belongs to the sulfur carrier protein TusA family
SSO_RS09825	COG1024	Enoyl-CoA hydratase
SSO_RS09895	COG1011	Hydrolase
SSO_RS09945	COG0477	Major facilitator Superfamily
SSO_RS09955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SSO_RS09960	COG1953	Uracil, thiamine, allantoin
SSO_RS09965	COG0531	amino acid
SSO_RS09970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SSO_RS09985	COG0477	Major facilitator Superfamily
SSO_RS10015	COG2368	4-hydroxyphenylacetate
SSO_RS10025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SSO_RS10030	COG2271	Major facilitator Superfamily
SSO_RS10040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SSO_RS10045	COG1960	acyl-CoA dehydrogenase activity
SSO_RS10055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SSO_RS10085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SSO_RS10090	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SSO_RS10095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SSO_RS10130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SSO_RS10130	COG2146	nitrite reductase [NAD(P)H] activity
SSO_RS10155	COG0412	Dienelactone hydrolase
SSO_RS10215	COG0793	Belongs to the peptidase S41A family
SSO_RS10215	COG4946	Tricorn protease homolog
SSO_RS10220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SSO_RS10325	COG1121	(ABC) transporter
SSO_RS10340	COG1305	Transglutaminase-like
SSO_RS10350	COG0450	alkyl hydroperoxide reductase
SSO_RS10380	COG1620	l-lactate permease
SSO_RS10395	COG0674	pyruvate-flavodoxin oxidoreductase activity
SSO_RS10400	COG1013	pyruvate-flavodoxin oxidoreductase activity
SSO_RS10405	COG1522	sequence-specific DNA binding
SSO_RS10425	COG0477	Major facilitator Superfamily
SSO_RS10435	COG1131	(ABC) transporter
SSO_RS10520	COG0561	phosphatase activity
SSO_RS10525	COG2264	protein methyltransferase activity
SSO_RS10530	COG1011	Hydrolase
SSO_RS10545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SSO_RS10580	COG0494	nUDIX hydrolase
SSO_RS10590	COG3253	May function as heme-dependent peroxidase
SSO_RS10605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SSO_RS10610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SSO_RS10610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SSO_RS10635	COG2226	methyltransferase
SSO_RS10660	COG0538	isocitrate dehydrogenase activity
SSO_RS10685	COG2154	pterin-4-alpha-carbinolamine dehydratase
SSO_RS10765	COG1331	Highly conserved protein containing a thioredoxin domain
SSO_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
SSO_RS10775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SSO_RS10785	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SSO_RS10810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SSO_RS10825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SSO_RS10850	COG0492	ferredoxin-NADP+ reductase activity
SSO_RS10895	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
SSO_RS10920	COG0588	phosphoglycerate mutase activity
SSO_RS10950	COG1957	nucleoside hydrolase
SSO_RS10980	COG0497	DNA recombination
SSO_RS11000	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SSO_RS11000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SSO_RS11005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SSO_RS11010	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
SSO_RS11045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SSO_RS11090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SSO_RS11095	COG1573	uracil-dna glycosylase
SSO_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
SSO_RS11125	COG0215	cysteine-tRNA ligase activity
SSO_RS11130	COG2222	sugar isomerase
SSO_RS11140	COG0446	pyridine nucleotide-disulphide oxidoreductase
SSO_RS11150	COG0433	COG0433 Predicted ATPase
SSO_RS11160	COG1607	acyl-coa hydrolase
SSO_RS11170	COG1028	Short-chain dehydrogenase reductase Sdr
SSO_RS11175	COG0708	Exodeoxyribonuclease III
SSO_RS11180	COG2815	serine threonine protein kinase
SSO_RS11180	COG0515	serine threonine protein kinase
SSO_RS11250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SSO_RS11390	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SSO_RS11395	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SSO_RS11410	COG0189	ligase activity
SSO_RS11470	COG1053	succinate dehydrogenase
SSO_RS11490	COG2304	oxidoreductase activity
SSO_RS11495	COG0714	Associated with various cellular activities
SSO_RS11515	COG0083	homoserine kinase activity
SSO_RS11520	COG0626	cystathionine gamma-synthase activity
SSO_RS11560	COG0183	Belongs to the thiolase family
SSO_RS11565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SSO_RS11620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SSO_RS11630	COG0351	phosphomethylpyrimidine kinase
SSO_RS11635	COG0314	molybdopterin synthase activity
SSO_RS11670	COG1131	(ABC) transporter
SSO_RS11675	COG1668	transmembrane transport
SSO_RS11695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SSO_RS11700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SSO_RS11730	COG0720	synthase
SSO_RS11745	COG0492	ferredoxin-NADP+ reductase activity
SSO_RS11750	COG0483	inositol monophosphate 1-phosphatase activity
SSO_RS11755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SSO_RS11770	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SSO_RS11775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SSO_RS11775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SSO_RS11785	COG0071	Belongs to the small heat shock protein (HSP20) family
SSO_RS11845	COG0402	S-adenosylhomocysteine deaminase activity
SSO_RS11870	COG0430	RNA-3'-phosphate cyclase activity
SSO_RS11885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SSO_RS11890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SSO_RS11900	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SSO_RS11905	COG5599	Phosphatase
SSO_RS11910	COG1515	deoxyribonuclease V activity
SSO_RS11915	COG1335	isochorismatase
SSO_RS11950	COG4581	dead DEAH box helicase
SSO_RS11960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SSO_RS11970	COG0439	Biotin carboxylase
SSO_RS11980	COG1116	anion transmembrane transporter activity
SSO_RS11990	COG0066	3-isopropylmalate dehydratase activity
SSO_RS11995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SSO_RS12000	COG0415	Belongs to the DNA photolyase family
SSO_RS12035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SSO_RS12070	COG0045	succinate-CoA ligase (ADP-forming) activity
SSO_RS12085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SSO_RS12090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SSO_RS12120	COG0657	acetylesterase activity
SSO_RS12125	COG1063	alcohol dehydrogenase
SSO_RS12130	COG0183	Belongs to the thiolase family
SSO_RS12135	COG1960	acyl-CoA dehydrogenase activity
SSO_RS12140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SSO_RS12145	COG1028	Short-chain dehydrogenase reductase Sdr
SSO_RS12150	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SSO_RS12170	COG1309	transcriptional regulator
SSO_RS12190	COG0318	PFAM AMP-dependent synthetase and ligase
SSO_RS12195	COG1960	acyl-CoA dehydrogenase activity
SSO_RS12200	COG1024	Enoyl-CoA hydratase
SSO_RS12205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SSO_RS12210	COG0477	Major facilitator Superfamily
SSO_RS12235	COG0657	acetylesterase activity
SSO_RS12245	COG0318	PFAM AMP-dependent synthetase and ligase
SSO_RS12255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SSO_RS12260	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SSO_RS12265	COG0477	Major facilitator Superfamily
SSO_RS12285	COG0432	Pfam Uncharacterised protein family UPF0047
SSO_RS12295	COG1024	Enoyl-CoA hydratase
SSO_RS12305	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SSO_RS12415	COG0477	Major facilitator Superfamily
SSO_RS12420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSO_RS12425	COG0778	Nitroreductase
SSO_RS12480	COG1489	DNA binding
SSO_RS12500	COG0750	zinc metalloprotease
SSO_RS12535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SSO_RS12540	COG0039	L-malate dehydrogenase activity
SSO_RS12545	COG2079	MmgE PrpD family protein
SSO_RS12550	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SSO_RS12555	COG0516	GMP reductase activity
SSO_RS12555	COG0517	IMP dehydrogenase activity
SSO_RS12560	COG0372	Belongs to the citrate synthase family
SSO_RS12575	COG0149	triose-phosphate isomerase activity
SSO_RS12605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SSO_RS12610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SSO_RS12640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SSO_RS12660	COG0438	transferase activity, transferring glycosyl groups
SSO_RS12675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SSO_RS12680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SSO_RS12690	COG4608	Belongs to the ABC transporter superfamily
SSO_RS12695	COG0444	Belongs to the ABC transporter superfamily
SSO_RS12700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SSO_RS12705	COG0601	transmembrane transport
SSO_RS12730	COG1024	Enoyl-CoA hydratase
SSO_RS12740	COG0183	Belongs to the thiolase family
SSO_RS12825	COG1592	Rubrerythrin
SSO_RS12850	COG4555	ABC transporter
SSO_RS12860	COG2217	Heavy metal translocating P-type atpase
SSO_RS12920	COG1028	Short-chain dehydrogenase reductase Sdr
SSO_RS12925	COG4948	Mandelate Racemase Muconate Lactonizing
SSO_RS12940	COG0601	transmembrane transport
SSO_RS12955	COG0444	Belongs to the ABC transporter superfamily
SSO_RS12960	COG4608	Belongs to the ABC transporter superfamily
SSO_RS13000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SSO_RS13040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSO_RS13050	COG2239	Acts as a magnesium transporter
SSO_RS13055	COG0823	Involved in the tonB-independent uptake of proteins
SSO_RS13055	COG1506	peptidase
SSO_RS13055	COG4946	Tricorn protease homolog
SSO_RS13060	COG0501	Belongs to the peptidase M48B family
SSO_RS13065	COG4274	PFAM GYD family protein
SSO_RS13105	COG2814	Major facilitator Superfamily
SSO_RS13110	COG3386	PFAM SMP-30 Gluconolaconase
SSO_RS13115	COG0813	purine-nucleoside phosphorylase activity
SSO_RS13150	COG0395	ABC-type sugar transport system, permease component
SSO_RS13155	COG2814	Major facilitator Superfamily
SSO_RS13160	COG1063	alcohol dehydrogenase
SSO_RS13170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SSO_RS13240	COG1573	uracil-dna glycosylase
SSO_RS13265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SSO_RS13275	COG0517	IMP dehydrogenase activity
SSO_RS13285	COG3387	PFAM Glycoside hydrolase 15-related
SSO_RS13345	COG3387	PFAM Glycoside hydrolase 15-related
SSO_RS13350	COG0438	transferase activity, transferring glycosyl groups
SSO_RS13355	COG1013	pyruvate-flavodoxin oxidoreductase activity
SSO_RS13360	COG0674	pyruvate-flavodoxin oxidoreductase activity
SSO_RS13365	COG1144	Oxidoreductase
SSO_RS13370	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SSO_RS13375	COG0437	4 iron, 4 sulfur cluster binding
SSO_RS13390	COG1960	acyl-CoA dehydrogenase activity
SSO_RS13400	COG2086	electron transfer activity
SSO_RS13410	COG0492	ferredoxin-NADP+ reductase activity
SSO_RS13430	COG0668	transmembrane transport
SSO_RS13435	COG0402	S-adenosylhomocysteine deaminase activity
SSO_RS13450	COG3962	Belongs to the TPP enzyme family
SSO_RS13455	COG0438	transferase activity, transferring glycosyl groups
SSO_RS13465	COG0644	oxidoreductase
SSO_RS13475	COG0589	response to stress
SSO_RS13480	COG0656	L-ascorbic acid biosynthetic process
SSO_RS13525	COG0668	transmembrane transport
SSO_RS13530	COG0586	Pfam SNARE associated Golgi protein
SSO_RS13545	COG3511	phospholipase C
SSO_RS13570	COG0437	4 iron, 4 sulfur cluster binding
SSO_RS13575	COG0243	molybdopterin cofactor binding
SSO_RS13600	COG1063	alcohol dehydrogenase
SSO_RS13620	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SSO_RS13640	COG0318	PFAM AMP-dependent synthetase and ligase
SSO_RS13675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SSO_RS13675	COG0674	pyruvate-flavodoxin oxidoreductase activity
SSO_RS13680	COG1013	pyruvate-flavodoxin oxidoreductase activity
SSO_RS13685	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SSO_RS13690	COG0644	oxidoreductase
SSO_RS13700	COG0574	Belongs to the PEP-utilizing enzyme family
SSO_RS13700	COG3848	Pyruvate phosphate dikinase
SSO_RS13705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SSO_RS13715	COG3383	formate dehydrogenase (NAD+) activity
SSO_RS13755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SSO_RS13835	COG1175	transmembrane transport
SSO_RS13840	COG0395	ABC-type sugar transport system, permease component
SSO_RS13845	COG3842	ATPase activity
SSO_RS13850	COG0477	Major facilitator Superfamily
SSO_RS13895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SSO_RS13900	COG1584	GPR1 FUN34 yaaH family protein
SSO_RS13925	COG0281	malic enzyme
SSO_RS13935	COG1250	3-hydroxyacyl-CoA dehydrogenase
SSO_RS13950	COG0318	PFAM AMP-dependent synthetase and ligase
SSO_RS13955	COG1960	acyl-CoA dehydrogenase activity
SSO_RS13965	COG3608	succinylglutamate desuccinylase aspartoacylase
SSO_RS13965	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SSO_RS14010	COG0667	Aldo Keto reductase
SSO_RS14055	COG2217	Heavy metal translocating P-type atpase
SSO_RS14080	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SSO_RS14080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SSO_RS14090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SSO_RS14130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SSO_RS14245	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SSO_RS14260	COG0477	Major facilitator Superfamily
SSO_RS14265	COG3473	Maleate cis-trans isomerase
SSO_RS14275	COG0179	Fumarylacetoacetate (FAA) hydrolase
SSO_RS14375	COG0028	Belongs to the TPP enzyme family
SSO_RS14380	COG2264	protein methyltransferase activity
SSO_RS14420	COG2857	Cytochrome c1
SSO_RS14420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SSO_RS14435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SSO_RS14455	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SSO_RS14550	COG1914	H( )-stimulated, divalent metal cation uptake system
SSO_RS14555	COG1250	3-hydroxyacyl-CoA dehydrogenase
SSO_RS14560	COG4948	Mandelate Racemase Muconate Lactonizing
SSO_RS14565	COG0459	protein refolding
SSO_RS14580	COG1028	Short-chain dehydrogenase reductase Sdr
SSO_RS14595	COG0673	inositol 2-dehydrogenase activity
SSO_RS14615	COG1132	(ABC) transporter
SSO_RS14625	COG0667	Aldo Keto reductase
SSO_RS14650	COG2723	6-phospho-beta-galactosidase activity
SSO_RS14660	COG1501	Belongs to the glycosyl hydrolase 31 family
SSO_RS14710	COG1472	Belongs to the glycosyl hydrolase 3 family
SSO_RS14730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SSO_RS14735	COG3250	beta-galactosidase activity
SSO_RS14755	COG3386	PFAM SMP-30 Gluconolaconase
SSO_RS14770	COG4608	Belongs to the ABC transporter superfamily
SSO_RS14775	COG0444	Belongs to the ABC transporter superfamily
SSO_RS14780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SSO_RS14790	COG0673	inositol 2-dehydrogenase activity
SSO_RS14815	COG0667	Aldo Keto reductase
SSO_RS14860	COG0318	PFAM AMP-dependent synthetase and ligase
SSO_RS14875	COG0395	ABC-type sugar transport system, permease component
SSO_RS14880	COG3842	ATPase activity
SSO_RS14890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SSO_RS14960	COG1136	(ABC) transporter
SSO_RS14980	COG0425	Belongs to the sulfur carrier protein TusA family
SSO_RS15020	COG1122	ATPase activity
SSO_RS15065	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SSO_RS15080	COG0805	protein transport
SSO_RS15110	COG1028	Short-chain dehydrogenase reductase Sdr
SSO_RS15120	COG2267	carboxylic ester hydrolase activity
SSO_RS15130	COG0179	Fumarylacetoacetate (FAA) hydrolase
SSO_RS15135	COG2271	Major facilitator Superfamily
SSO_RS15140	COG0477	Major facilitator Superfamily
SSO_RS15150	COG4948	Mandelate Racemase Muconate Lactonizing
SSO_RS15175	COG2814	Major facilitator Superfamily
SSO_RS15180	COG1139	Iron-sulfur cluster binding protein
SSO_RS15190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SSO_RS15205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SSO_RS15235	COG2271	Major facilitator Superfamily
SSO_RS15255	COG0477	Major facilitator Superfamily
SSO_RS15265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSO_RS15300	COG0655	NAD(P)H dehydrogenase (quinone) activity
SSO_RS15315	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SSO_RS15320	COG0095	Lipoate-protein ligase
SSO_RS15325	COG0247	lactate metabolic process
SSO_RS15330	COG0277	FAD linked oxidase domain protein
SSO_RS15370	COG1720	tRNA m6t6A37 methyltransferase activity
SSO_RS15385	COG0516	GMP reductase activity
SSO_RS15385	COG0517	IMP dehydrogenase activity
SSO_RS15395	COG1733	regulation of RNA biosynthetic process
SSO_RS15415	COG2814	Major facilitator Superfamily
SSO_RS15425	COG2815	serine threonine protein kinase
SSO_RS15425	COG0515	serine threonine protein kinase
SSO_RS15430	COG0589	response to stress
SSO_RS15470	COG0530	calcium, potassium:sodium antiporter activity
SSO_RS15475	COG1012	belongs to the aldehyde dehydrogenase family
SSO_RS15485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SSO_RS15490	COG4948	Mandelate Racemase Muconate Lactonizing
SSO_RS15505	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SSO_RS15515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SSO_RS15520	COG1063	alcohol dehydrogenase
SSO_RS15525	COG0517	IMP dehydrogenase activity
SSO_RS15525	COG0516	GMP reductase activity
SSO_RS15545	COG0656	L-ascorbic acid biosynthetic process
SSO_RS15555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SSO_RS15570	COG1444	tRNA N-acetyltransferase activity
SSO_RS15585	COG0405	Gamma-glutamyltransferase
SSO_RS15620	COG1830	Aldolase
SSO_RS15630	COG0516	GMP reductase activity
SSO_RS15630	COG0517	IMP dehydrogenase activity
SSO_RS15635	COG0501	Belongs to the peptidase M48B family
SSO_RS15640	COG0519	Catalyzes the synthesis of GMP from XMP
SSO_RS15640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SSO_RS15650	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SSO_RS15660	COG1063	alcohol dehydrogenase
SSO_RS15680	COG0463	Glycosyl transferase, family 2
SSO_RS15775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SSO_RS16075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SSO_RS16150	COG0675	Transposase, IS605 OrfB family
SSO_RS16750	COG1131	(ABC) transporter