locus-tag	class	description
GFS33_RS00115	COG0069	glutamate synthase activity
GFS33_RS00120	COG0067	glutamate synthase
GFS33_RS00135	COG0402	S-adenosylhomocysteine deaminase activity
GFS33_RS00145	COG0746	molybdenum cofactor guanylyltransferase activity
GFS33_RS00150	COG0303	'Molybdopterin
GFS33_RS00195	COG2379	hydroxypyruvate reductase
GFS33_RS00200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS33_RS00210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GFS33_RS00210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GFS33_RS00220	COG0312	modulator of DNA gyrase
GFS33_RS00225	COG0864	Transcriptional regulator
GFS33_RS00235	COG0460	homoserine dehydrogenase
GFS33_RS00240	COG0109	protoheme IX farnesyltransferase activity
GFS33_RS00250	COG1024	Enoyl-CoA hydratase
GFS33_RS00290	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFS33_RS00300	COG0189	ligase activity
GFS33_RS00315	COG0165	Argininosuccinate lyase
GFS33_RS00320	COG0137	argininosuccinate synthase activity
GFS33_RS00335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GFS33_RS00340	COG0151	Belongs to the GarS family
GFS33_RS00345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GFS33_RS00350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GFS33_RS00355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFS33_RS00360	COG0047	phosphoribosylformylglycinamidine synthase activity
GFS33_RS00370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFS33_RS00375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFS33_RS00375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFS33_RS00380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFS33_RS00385	COG0602	queuosine metabolic process
GFS33_RS00420	COG0284	orotidine-5'-phosphate decarboxylase activity
GFS33_RS00425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GFS33_RS00435	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GFS33_RS00445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFS33_RS00450	COG0167	dihydroorotate dehydrogenase activity
GFS33_RS00465	COG2095	MarC family integral membrane protein
GFS33_RS00470	COG1522	sequence-specific DNA binding
GFS33_RS00485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFS33_RS00490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFS33_RS00495	COG2151	metal-sulfur cluster biosynthetic enzyme
GFS33_RS00505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFS33_RS00510	COG0140	phosphoribosyl-ATP diphosphatase activity
GFS33_RS00510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GFS33_RS00520	COG0107	imidazoleglycerol-phosphate synthase activity
GFS33_RS00525	COG0131	Imidazoleglycerol-phosphate dehydratase
GFS33_RS00530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GFS33_RS00535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GFS33_RS00540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFS33_RS00550	COG0495	leucyl-tRNA aminoacylation
GFS33_RS00555	COG2096	Adenosyltransferase
GFS33_RS00560	COG0037	tRNA processing
GFS33_RS00570	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GFS33_RS00605	COG0028	Belongs to the TPP enzyme family
GFS33_RS00615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFS33_RS00630	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GFS33_RS00635	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GFS33_RS00645	COG0442	prolyl-tRNA aminoacylation
GFS33_RS00660	COG1394	ATPase activity, coupled to movement of substances
GFS33_RS00670	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GFS33_RS00690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFS33_RS00725	COG0417	DNA replication proofreading
GFS33_RS00755	COG0126	phosphoglycerate kinase activity
GFS33_RS00765	COG0589	response to stress
GFS33_RS00770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFS33_RS00790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFS33_RS00795	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GFS33_RS00875	COG0495	leucyl-tRNA aminoacylation
GFS33_RS00930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFS33_RS00945	COG1121	(ABC) transporter
GFS33_RS00960	COG0805	protein transport
GFS33_RS00970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFS33_RS00995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFS33_RS01005	COG0556	nucleotide-excision repair
GFS33_RS01010	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GFS33_RS01020	COG3276	selenocysteine insertion sequence binding
GFS33_RS01040	COG0351	phosphomethylpyrimidine kinase
GFS33_RS01040	COG1992	Thiamine-phosphate synthase
GFS33_RS01070	COG0489	protein tyrosine kinase activity
GFS33_RS01090	COG1280	lysine exporter protein (LysE YggA)
GFS33_RS01120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFS33_RS01165	COG0010	Belongs to the arginase family
GFS33_RS01170	COG0423	glycine-tRNA ligase activity
GFS33_RS01200	COG0163	prenyltransferase activity
GFS33_RS01210	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
GFS33_RS01235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFS33_RS01240	COG0667	Aldo Keto reductase
GFS33_RS01285	COG1110	DNA topoisomerase II activity
GFS33_RS01290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS33_RS01295	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GFS33_RS01340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFS33_RS01355	COG1797	cobyrinic acid a,c-diamide synthase activity
GFS33_RS01375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GFS33_RS01385	COG0402	S-adenosylhomocysteine deaminase activity
GFS33_RS01405	COG1201	RNA secondary structure unwinding
GFS33_RS01415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFS33_RS01420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFS33_RS01425	COG2813	Specifically methylates the guanine in position
GFS33_RS01435	COG1444	tRNA N-acetyltransferase activity
GFS33_RS01470	COG1215	transferase activity, transferring glycosyl groups
GFS33_RS01490	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFS33_RS01495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFS33_RS01505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFS33_RS01540	COG0535	radical SAM domain protein
GFS33_RS01545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GFS33_RS01565	COG3118	belongs to the thioredoxin family
GFS33_RS01570	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GFS33_RS01585	COG0302	gtp cyclohydrolase
GFS33_RS01595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GFS33_RS01610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFS33_RS01690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFS33_RS01700	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFS33_RS01740	COG0301	tRNA thio-modification
GFS33_RS01745	COG1260	myo-inositol-1-phosphate synthase
GFS33_RS01750	COG1007	ATP synthesis coupled electron transport
GFS33_RS01755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFS33_RS01760	COG0713	ATP synthesis coupled electron transport
GFS33_RS01770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS33_RS01780	COG0649	NAD binding
GFS33_RS01785	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS33_RS01795	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GFS33_RS01815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFS33_RS01860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GFS33_RS01870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GFS33_RS01875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFS33_RS01880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GFS33_RS01885	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GFS33_RS01890	COG0077	Prephenate dehydratase
GFS33_RS01890	COG1605	Chorismate mutase
GFS33_RS01895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFS33_RS01900	COG3959	Transketolase, thiamine diphosphate binding domain
GFS33_RS01905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GFS33_RS01925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GFS33_RS01970	COG1121	(ABC) transporter
GFS33_RS01975	COG1980	fructose-bisphosphate aldolase activity
GFS33_RS02000	COG0459	protein refolding
GFS33_RS02015	COG0124	histidyl-tRNA synthetase
GFS33_RS02050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS33_RS02060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFS33_RS02105	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GFS33_RS02155	COG1051	belongs to the nudix hydrolase family
GFS33_RS02155	COG1056	cytidyltransferase-related domain
GFS33_RS02170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFS33_RS02170	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GFS33_RS02195	COG0077	Prephenate dehydratase
GFS33_RS02195	COG1605	Chorismate mutase
GFS33_RS02210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFS33_RS02225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GFS33_RS02240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GFS33_RS02295	COG0085	RNA polymerase activity
GFS33_RS02300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFS33_RS02330	COG0049	tRNA binding
GFS33_RS02335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GFS33_RS02340	COG0051	transcription antitermination factor activity, RNA binding
GFS33_RS02385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GFS33_RS02395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFS33_RS02415	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GFS33_RS02435	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
GFS33_RS02465	COG2078	PFAM AMMECR1 domain protein
GFS33_RS02480	COG0717	Belongs to the dCTP deaminase family
GFS33_RS02485	COG1793	dna ligase
GFS33_RS02495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFS33_RS02530	COG0113	porphobilinogen synthase activity
GFS33_RS02535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GFS33_RS02555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS33_RS02580	COG0017	Asparaginyl-tRNA synthetase
GFS33_RS02605	COG0028	Belongs to the TPP enzyme family
GFS33_RS02620	COG1129	ABC transporter
GFS33_RS02650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFS33_RS02660	COG0189	ligase activity
GFS33_RS02675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GFS33_RS02695	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GFS33_RS02760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFS33_RS02765	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GFS33_RS02780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFS33_RS02780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFS33_RS02815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFS33_RS02830	COG1201	RNA secondary structure unwinding
GFS33_RS02865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFS33_RS02870	COG1058	Belongs to the CinA family
GFS33_RS02870	COG1546	Belongs to the CinA family
GFS33_RS02890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFS33_RS02920	COG0561	phosphatase activity
GFS33_RS02940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFS33_RS02970	COG0454	-acetyltransferase
GFS33_RS02985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFS33_RS03000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFS33_RS03005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFS33_RS03010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFS33_RS03025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFS33_RS03030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFS33_RS03040	COG0052	Belongs to the universal ribosomal protein uS2 family
GFS33_RS03045	COG1355	regulation of microtubule-based process
GFS33_RS03060	COG1304	FMN binding
GFS33_RS03130	COG1695	Transcriptional regulator
GFS33_RS03165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFS33_RS03195	COG1192	Involved in chromosome partitioning
GFS33_RS03225	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GFS33_RS03270	COG1201	RNA secondary structure unwinding
GFS33_RS03300	COG2860	membrane
GFS33_RS03320	COG0123	including yeast histone deacetylase and acetoin utilization protein
GFS33_RS03335	COG1234	tRNA 3'-trailer cleavage
GFS33_RS03340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFS33_RS03405	COG0463	Glycosyl transferase, family 2
GFS33_RS03430	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GFS33_RS03445	COG0519	Catalyzes the synthesis of GMP from XMP
GFS33_RS03445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFS33_RS03450	COG0501	Belongs to the peptidase M48B family
GFS33_RS03455	COG0516	GMP reductase activity
GFS33_RS03455	COG0517	IMP dehydrogenase activity
GFS33_RS03465	COG1830	Aldolase
GFS33_RS03490	COG0405	Gamma-glutamyltransferase
GFS33_RS03505	COG1444	tRNA N-acetyltransferase activity
GFS33_RS03520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFS33_RS03530	COG0667	Aldo Keto reductase
GFS33_RS03550	COG0617	tRNA 3'-terminal CCA addition
GFS33_RS03550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFS33_RS03550	COG0517	IMP dehydrogenase activity
GFS33_RS03555	COG1063	alcohol dehydrogenase
GFS33_RS03560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS33_RS03570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFS33_RS03585	COG4948	Mandelate Racemase Muconate Lactonizing
GFS33_RS03590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFS33_RS03595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFS33_RS03600	COG1012	belongs to the aldehyde dehydrogenase family
GFS33_RS03605	COG0530	calcium, potassium:sodium antiporter activity
GFS33_RS03610	COG0243	molybdopterin cofactor binding
GFS33_RS03660	COG2814	Major facilitator Superfamily
GFS33_RS03685	COG1733	regulation of RNA biosynthetic process
GFS33_RS03695	COG0516	GMP reductase activity
GFS33_RS03695	COG0517	IMP dehydrogenase activity
GFS33_RS03710	COG1720	tRNA m6t6A37 methyltransferase activity
GFS33_RS03760	COG0247	lactate metabolic process
GFS33_RS03765	COG0095	Lipoate-protein ligase
GFS33_RS03770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFS33_RS03785	COG0655	NAD(P)H dehydrogenase (quinone) activity
GFS33_RS03805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS33_RS03810	COG0477	Major facilitator Superfamily
GFS33_RS03835	COG2271	Major facilitator Superfamily
GFS33_RS03870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFS33_RS03880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFS33_RS03890	COG1139	Iron-sulfur cluster binding protein
GFS33_RS03895	COG2814	Major facilitator Superfamily
GFS33_RS03920	COG4948	Mandelate Racemase Muconate Lactonizing
GFS33_RS03930	COG0477	Major facilitator Superfamily
GFS33_RS03935	COG2271	Major facilitator Superfamily
GFS33_RS03950	COG2267	carboxylic ester hydrolase activity
GFS33_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
GFS33_RS03990	COG0805	protein transport
GFS33_RS04005	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GFS33_RS04050	COG1134	teichoic acid transport
GFS33_RS04095	COG0425	Belongs to the sulfur carrier protein TusA family
GFS33_RS04115	COG1121	(ABC) transporter
GFS33_RS04170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFS33_RS04180	COG3842	ATPase activity
GFS33_RS04190	COG1175	transmembrane transport
GFS33_RS04200	COG0318	PFAM AMP-dependent synthetase and ligase
GFS33_RS04255	COG1129	ABC transporter
GFS33_RS04260	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFS33_RS04270	COG1028	Short-chain dehydrogenase reductase Sdr
GFS33_RS04275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFS33_RS04280	COG2030	dehydratase
GFS33_RS04290	COG1312	Catalyzes the dehydration of D-mannonate
GFS33_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
GFS33_RS04315	COG1024	Enoyl-CoA hydratase
GFS33_RS04320	COG2814	Major facilitator Superfamily
GFS33_RS04330	COG1960	acyl-CoA dehydrogenase activity
GFS33_RS04340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFS33_RS04395	COG4948	Mandelate Racemase Muconate Lactonizing
GFS33_RS04485	COG0673	inositol 2-dehydrogenase activity
GFS33_RS04490	COG1132	(ABC) transporter
GFS33_RS04550	COG0459	protein refolding
GFS33_RS04555	COG4948	Mandelate Racemase Muconate Lactonizing
GFS33_RS04560	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFS33_RS04565	COG1914	H( )-stimulated, divalent metal cation uptake system
GFS33_RS04650	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GFS33_RS04675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFS33_RS04740	COG0675	Transposase, IS605 OrfB family
GFS33_RS04755	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GFS33_RS04780	COG0717	Belongs to the dCTP deaminase family
GFS33_RS04815	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
GFS33_RS04850	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFS33_RS04860	COG2897	thiosulfate sulfurtransferase activity
GFS33_RS04910	COG0667	Aldo Keto reductase
GFS33_RS04925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFS33_RS04940	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFS33_RS04940	COG3608	succinylglutamate desuccinylase aspartoacylase
GFS33_RS04950	COG1960	acyl-CoA dehydrogenase activity
GFS33_RS04955	COG0318	PFAM AMP-dependent synthetase and ligase
GFS33_RS04960	COG0183	Belongs to the thiolase family
GFS33_RS04970	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFS33_RS04980	COG0281	malic enzyme
GFS33_RS05025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS33_RS05065	COG3842	ATPase activity
GFS33_RS05070	COG0395	ABC-type sugar transport system, permease component
GFS33_RS05120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS33_RS05180	COG3383	formate dehydrogenase (NAD+) activity
GFS33_RS05190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GFS33_RS05195	COG0574	Belongs to the PEP-utilizing enzyme family
GFS33_RS05195	COG3848	Pyruvate phosphate dikinase
GFS33_RS05205	COG0644	oxidoreductase
GFS33_RS05210	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GFS33_RS05215	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFS33_RS05220	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFS33_RS05220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GFS33_RS05255	COG0318	PFAM AMP-dependent synthetase and ligase
GFS33_RS05275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GFS33_RS05295	COG1063	alcohol dehydrogenase
GFS33_RS05315	COG0668	transmembrane transport
GFS33_RS05320	COG0586	Pfam SNARE associated Golgi protein
GFS33_RS05325	COG0022	dehydrogenase e1 component
GFS33_RS05330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFS33_RS05335	COG0656	L-ascorbic acid biosynthetic process
GFS33_RS05340	COG0589	response to stress
GFS33_RS05350	COG0644	oxidoreductase
GFS33_RS05365	COG0028	Belongs to the TPP enzyme family
GFS33_RS05380	COG0402	S-adenosylhomocysteine deaminase activity
GFS33_RS05415	COG2086	electron transfer activity
GFS33_RS05425	COG1960	acyl-CoA dehydrogenase activity
GFS33_RS05445	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GFS33_RS05450	COG1144	Oxidoreductase
GFS33_RS05455	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFS33_RS05460	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFS33_RS05465	COG0438	transferase activity, transferring glycosyl groups
GFS33_RS05470	COG3387	PFAM Glycoside hydrolase 15-related
GFS33_RS05545	COG0517	IMP dehydrogenase activity
GFS33_RS05555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFS33_RS05645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFS33_RS05650	COG2271	Major facilitator Superfamily
GFS33_RS05660	COG2814	Major facilitator Superfamily
GFS33_RS05680	COG0395	ABC-type sugar transport system, permease component
GFS33_RS05685	COG3842	ATPase activity
GFS33_RS05710	COG2259	Doxx family
GFS33_RS05720	COG0813	purine-nucleoside phosphorylase activity
GFS33_RS05725	COG3386	PFAM SMP-30 Gluconolaconase
GFS33_RS05730	COG2814	Major facilitator Superfamily
GFS33_RS05775	COG4274	PFAM GYD family protein
GFS33_RS05785	COG1506	peptidase
GFS33_RS05785	COG4946	Tricorn protease homolog
GFS33_RS05785	COG0823	Involved in the tonB-independent uptake of proteins
GFS33_RS05845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GFS33_RS05905	COG4608	Belongs to the ABC transporter superfamily
GFS33_RS05910	COG0444	Belongs to the ABC transporter superfamily
GFS33_RS05925	COG0601	transmembrane transport
GFS33_RS05945	COG1028	Short-chain dehydrogenase reductase Sdr
GFS33_RS06015	COG2217	Heavy metal translocating P-type atpase
GFS33_RS06025	COG4555	ABC transporter
GFS33_RS06050	COG1592	Rubrerythrin
GFS33_RS06135	COG0183	Belongs to the thiolase family
GFS33_RS06145	COG1024	Enoyl-CoA hydratase
GFS33_RS06205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFS33_RS06210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFS33_RS06230	COG0438	transferase activity, transferring glycosyl groups
GFS33_RS06245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GFS33_RS06270	COG1131	(ABC) transporter
GFS33_RS06275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GFS33_RS06280	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GFS33_RS06310	COG0149	triose-phosphate isomerase activity
GFS33_RS06325	COG0372	Belongs to the citrate synthase family
GFS33_RS06330	COG0516	GMP reductase activity
GFS33_RS06330	COG0517	IMP dehydrogenase activity
GFS33_RS06335	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GFS33_RS06345	COG0039	L-malate dehydrogenase activity
GFS33_RS06350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFS33_RS06430	COG0778	Nitroreductase
GFS33_RS06585	COG0561	phosphatase activity
GFS33_RS06590	COG2264	protein methyltransferase activity
GFS33_RS06595	COG1011	Hydrolase
GFS33_RS06650	COG0494	nUDIX hydrolase
GFS33_RS06655	COG3253	May function as heme-dependent peroxidase
GFS33_RS06670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFS33_RS06675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFS33_RS06675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFS33_RS06700	COG2226	methyltransferase
GFS33_RS06735	COG0538	isocitrate dehydrogenase activity
GFS33_RS06760	COG2154	pterin-4-alpha-carbinolamine dehydratase
GFS33_RS06840	COG1331	Highly conserved protein containing a thioredoxin domain
GFS33_RS06850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GFS33_RS06860	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GFS33_RS06885	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GFS33_RS06900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS33_RS06910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFS33_RS06915	COG2814	Major facilitator Superfamily
GFS33_RS06925	COG0492	ferredoxin-NADP+ reductase activity
GFS33_RS07000	COG0588	phosphoglycerate mutase activity
GFS33_RS07020	COG1957	nucleoside hydrolase
GFS33_RS07035	COG2226	methyltransferase
GFS33_RS07080	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
GFS33_RS07125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFS33_RS07130	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GFS33_RS07180	COG2192	nodulation
GFS33_RS07245	COG0675	Transposase, IS605 OrfB family
GFS33_RS07280	COG2217	Heavy metal translocating P-type atpase
GFS33_RS07360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFS33_RS07360	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GFS33_RS07435	COG4608	Belongs to the ABC transporter superfamily
GFS33_RS07440	COG0444	Belongs to the ABC transporter superfamily
GFS33_RS07450	COG0601	transmembrane transport
GFS33_RS07465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFS33_RS07480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFS33_RS07510	COG2721	sulfolactate sulfo-lyase activity
GFS33_RS07515	COG2721	sulfolactate sulfo-lyase activity
GFS33_RS07520	COG4948	Mandelate Racemase Muconate Lactonizing
GFS33_RS07540	COG0598	Magnesium transport protein CorA
GFS33_RS07555	COG1802	Transcriptional regulator
GFS33_RS07560	COG2301	Belongs to the HpcH HpaI aldolase family
GFS33_RS07565	COG2050	protein possibly involved in aromatic compounds catabolism
GFS33_RS07565	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GFS33_RS07580	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFS33_RS07580	COG3608	succinylglutamate desuccinylase aspartoacylase
GFS33_RS07600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GFS33_RS07665	COG0028	Belongs to the TPP enzyme family
GFS33_RS07670	COG2151	metal-sulfur cluster biosynthetic enzyme
GFS33_RS07695	COG3350	monooxygenase activity
GFS33_RS07730	COG1063	alcohol dehydrogenase
GFS33_RS07740	COG1012	belongs to the aldehyde dehydrogenase family
GFS33_RS07765	COG0277	FAD linked oxidase domain protein
GFS33_RS07805	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFS33_RS07810	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFS33_RS07825	COG2062	phosphohistidine phosphatase, SixA
GFS33_RS07835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFS33_RS07840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFS33_RS07880	COG1335	isochorismatase
GFS33_RS07910	COG1122	ATPase activity
GFS33_RS07935	COG0450	alkyl hydroperoxide reductase
GFS33_RS07945	COG1620	l-lactate permease
GFS33_RS07960	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFS33_RS07965	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFS33_RS07970	COG1522	sequence-specific DNA binding
GFS33_RS07985	COG1305	Transglutaminase-like
GFS33_RS08000	COG0432	Pfam Uncharacterised protein family UPF0047
GFS33_RS08010	COG0500	methyltransferase
GFS33_RS08015	COG1024	Enoyl-CoA hydratase
GFS33_RS08025	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GFS33_RS08040	COG1012	belongs to the aldehyde dehydrogenase family
GFS33_RS08080	COG1131	(ABC) transporter
GFS33_RS08095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFS33_RS08105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GFS33_RS08115	COG0318	PFAM AMP-dependent synthetase and ligase
GFS33_RS08125	COG0657	acetylesterase activity
GFS33_RS08130	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFS33_RS08155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFS33_RS08160	COG1024	Enoyl-CoA hydratase
GFS33_RS08165	COG1960	acyl-CoA dehydrogenase activity
GFS33_RS08170	COG0318	PFAM AMP-dependent synthetase and ligase
GFS33_RS08190	COG1309	transcriptional regulator
GFS33_RS08195	COG2814	Major facilitator Superfamily
GFS33_RS08220	COG1028	Short-chain dehydrogenase reductase Sdr
GFS33_RS08225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFS33_RS08230	COG1960	acyl-CoA dehydrogenase activity
GFS33_RS08240	COG1063	alcohol dehydrogenase
GFS33_RS08245	COG0657	acetylesterase activity
GFS33_RS08310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFS33_RS08315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFS33_RS08330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GFS33_RS08375	COG0415	Belongs to the DNA photolyase family
GFS33_RS08380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFS33_RS08385	COG0066	3-isopropylmalate dehydratase activity
GFS33_RS08405	COG0439	Biotin carboxylase
GFS33_RS08415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFS33_RS08465	COG1515	deoxyribonuclease V activity
GFS33_RS08470	COG5599	Phosphatase
GFS33_RS08475	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GFS33_RS08485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS33_RS08490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFS33_RS08495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFS33_RS08505	COG0430	RNA-3'-phosphate cyclase activity
GFS33_RS08530	COG0402	S-adenosylhomocysteine deaminase activity
GFS33_RS08595	COG0071	Belongs to the small heat shock protein (HSP20) family
GFS33_RS08605	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFS33_RS08605	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFS33_RS08625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS33_RS08635	COG0492	ferredoxin-NADP+ reductase activity
GFS33_RS08650	COG0720	synthase
GFS33_RS08680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFS33_RS08685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFS33_RS08710	COG1131	(ABC) transporter
GFS33_RS08720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GFS33_RS08745	COG0314	molybdopterin synthase activity
GFS33_RS08750	COG0351	phosphomethylpyrimidine kinase
GFS33_RS08765	COG1215	transferase activity, transferring glycosyl groups
GFS33_RS08805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFS33_RS08810	COG0183	Belongs to the thiolase family
GFS33_RS08850	COG0626	cystathionine gamma-synthase activity
GFS33_RS08855	COG0083	homoserine kinase activity
GFS33_RS08875	COG0714	Associated with various cellular activities
GFS33_RS08880	COG2304	oxidoreductase activity
GFS33_RS08920	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GFS33_RS08960	COG0189	ligase activity
GFS33_RS08975	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GFS33_RS09100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFS33_RS09170	COG2815	serine threonine protein kinase
GFS33_RS09170	COG0515	serine threonine protein kinase
GFS33_RS09175	COG0708	Exodeoxyribonuclease III
GFS33_RS09180	COG1028	Short-chain dehydrogenase reductase Sdr
GFS33_RS09190	COG1607	acyl-coa hydrolase
GFS33_RS09200	COG0433	COG0433 Predicted ATPase
GFS33_RS09210	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFS33_RS09220	COG2222	sugar isomerase
GFS33_RS09225	COG0215	cysteine-tRNA ligase activity
GFS33_RS09250	COG1028	Short-chain dehydrogenase reductase Sdr
GFS33_RS09255	COG1573	uracil-dna glycosylase
GFS33_RS09300	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFS33_RS09340	COG0275	rRNA processing
GFS33_RS09350	COG0463	Glycosyl transferase, family 2
GFS33_RS09420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFS33_RS09455	COG2723	6-phospho-beta-galactosidase activity
GFS33_RS09620	COG1373	ATPase (AAA superfamily
GFS33_RS09630	COG1111	helicase
GFS33_RS09630	COG1205	dead DEAH box helicase
GFS33_RS09640	COG4948	Mandelate Racemase Muconate Lactonizing
GFS33_RS09645	COG0318	PFAM AMP-dependent synthetase and ligase
GFS33_RS09655	COG0318	PFAM AMP-dependent synthetase and ligase
GFS33_RS09660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS33_RS09675	COG4689	acetoacetate decarboxylase
GFS33_RS09680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS33_RS09700	COG2030	dehydratase
GFS33_RS09730	COG1960	acyl-CoA dehydrogenase activity
GFS33_RS09735	COG0095	Lipoate-protein ligase
GFS33_RS09750	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFS33_RS09755	COG3199	ATP-NAD kinase
GFS33_RS09760	COG0022	dehydrogenase e1 component
GFS33_RS09765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFS33_RS09770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS33_RS09775	COG0318	PFAM AMP-dependent synthetase and ligase
GFS33_RS09785	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFS33_RS09795	COG2267	carboxylic ester hydrolase activity
GFS33_RS09855	COG0477	Major facilitator Superfamily
GFS33_RS09865	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFS33_RS09925	COG0477	Major facilitator Superfamily
GFS33_RS09930	COG2828	Protein conserved in bacteria
GFS33_RS09935	COG0477	Major facilitator Superfamily
GFS33_RS09945	COG1063	alcohol dehydrogenase
GFS33_RS09960	COG4948	Mandelate Racemase Muconate Lactonizing
GFS33_RS10000	COG0477	Major facilitator Superfamily
GFS33_RS10015	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFS33_RS10045	COG0154	amidase activity
GFS33_RS10070	COG2226	methyltransferase
GFS33_RS10095	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GFS33_RS10105	COG0477	Major facilitator Superfamily
GFS33_RS10125	COG0477	Major facilitator Superfamily
GFS33_RS10165	COG0477	Major facilitator Superfamily
GFS33_RS10200	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GFS33_RS10215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFS33_RS10230	COG1053	succinate dehydrogenase
GFS33_RS10265	COG0596	Alpha beta hydrolase
GFS33_RS10320	COG2080	2 iron, 2 sulfur cluster binding
GFS33_RS10325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GFS33_RS10380	COG1201	RNA secondary structure unwinding
GFS33_RS10410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFS33_RS10440	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GFS33_RS10445	COG2224	Isocitrate lyase
GFS33_RS10465	COG1215	transferase activity, transferring glycosyl groups
GFS33_RS10490	COG0675	Transposase, IS605 OrfB family
GFS33_RS10515	COG1473	amidohydrolase
GFS33_RS10585	COG1215	transferase activity, transferring glycosyl groups
GFS33_RS10605	COG0675	Transposase, IS605 OrfB family
GFS33_RS10625	COG0318	PFAM AMP-dependent synthetase and ligase
GFS33_RS10630	COG1960	acyl-CoA dehydrogenase activity
GFS33_RS10695	COG0675	Transposase, IS605 OrfB family
GFS33_RS10725	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GFS33_RS10730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFS33_RS10735	COG2002	toxin-antitoxin pair type II binding
GFS33_RS10755	COG1454	alcohol dehydrogenase
GFS33_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
GFS33_RS10775	COG0535	radical SAM domain protein
GFS33_RS10780	COG0535	radical SAM domain protein
GFS33_RS10785	COG1012	belongs to the aldehyde dehydrogenase family
GFS33_RS10790	COG0519	Catalyzes the synthesis of GMP from XMP
GFS33_RS10800	COG0501	Belongs to the peptidase M48B family
GFS33_RS10805	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GFS33_RS10820	COG0589	response to stress
GFS33_RS10825	COG2151	metal-sulfur cluster biosynthetic enzyme
GFS33_RS10880	COG0577	efflux transmembrane transporter activity
GFS33_RS10880	COG1136	(ABC) transporter
GFS33_RS10925	COG2223	nitrite transmembrane transporter activity
GFS33_RS10930	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GFS33_RS10935	COG1140	nitrate reductase beta subunit
GFS33_RS10940	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GFS33_RS10945	COG2181	nitrate reductase activity
GFS33_RS10975	COG0425	Belongs to the sulfur carrier protein TusA family
GFS33_RS11000	COG1024	Enoyl-CoA hydratase
GFS33_RS11095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS33_RS11100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFS33_RS11135	COG0477	Major facilitator Superfamily
GFS33_RS11145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS33_RS11150	COG1953	Uracil, thiamine, allantoin
GFS33_RS11160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFS33_RS11170	COG2814	Major facilitator Superfamily
GFS33_RS11210	COG2368	4-hydroxyphenylacetate
GFS33_RS11220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFS33_RS11235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS33_RS11240	COG1960	acyl-CoA dehydrogenase activity
GFS33_RS11250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFS33_RS11280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS33_RS11285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFS33_RS11330	COG0412	Dienelactone hydrolase
GFS33_RS11370	COG0675	Transposase, IS605 OrfB family
GFS33_RS11380	COG4946	Tricorn protease homolog
GFS33_RS11380	COG0793	Belongs to the peptidase S41A family
GFS33_RS11495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS33_RS11525	COG2271	Major facilitator Superfamily
GFS33_RS11530	COG2814	Major facilitator Superfamily
GFS33_RS11540	COG0436	Aminotransferase
GFS33_RS11555	COG0530	calcium, potassium:sodium antiporter activity
GFS33_RS11565	COG2814	Major facilitator Superfamily
GFS33_RS11575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFS33_RS11595	COG1960	acyl-CoA dehydrogenase activity
GFS33_RS11635	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GFS33_RS11640	COG1131	(ABC) transporter
GFS33_RS11665	COG0475	glutathione-regulated potassium exporter activity
GFS33_RS11680	COG2048	Heterodisulfide reductase, subunit B
GFS33_RS11695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS33_RS11710	COG0425	Belongs to the sulfur carrier protein TusA family
GFS33_RS11715	COG2210	Belongs to the sulfur carrier protein TusA family
GFS33_RS11725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS33_RS11800	COG0095	Lipoate-protein ligase
GFS33_RS11805	COG1832	CoA-binding protein
GFS33_RS11840	COG0509	glycine decarboxylation via glycine cleavage system
GFS33_RS11850	COG2271	Major facilitator Superfamily
GFS33_RS11890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GFS33_RS11935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GFS33_RS11945	COG1846	Transcriptional regulator
GFS33_RS11950	COG1136	(ABC) transporter
GFS33_RS11950	COG0577	efflux transmembrane transporter activity
GFS33_RS11960	COG1136	(ABC) transporter
GFS33_RS11965	COG0114	fumarate hydratase activity
GFS33_RS11980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GFS33_RS11980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GFS33_RS11985	COG0693	protein deglycase activity
GFS33_RS11995	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFS33_RS12000	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFS33_RS12020	COG0509	glycine decarboxylation via glycine cleavage system
GFS33_RS12025	COG0095	Lipoate-protein ligase
GFS33_RS12055	COG0004	ammonium transporteR
GFS33_RS12080	COG1185	polyribonucleotide nucleotidyltransferase activity
GFS33_RS12125	COG1234	tRNA 3'-trailer cleavage
GFS33_RS12140	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GFS33_RS12170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GFS33_RS12180	COG0300	oxidoreductase activity
GFS33_RS12195	COG0650	Formate hydrogenlyase subunit 4
GFS33_RS12205	COG0651	ATP synthesis coupled electron transport
GFS33_RS12215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS33_RS12220	COG0651	ATP synthesis coupled electron transport
GFS33_RS12300	COG3842	ATPase activity
GFS33_RS12305	COG0395	ABC-type sugar transport system, permease component
GFS33_RS12325	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GFS33_RS12330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GFS33_RS12365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GFS33_RS12375	COG0297	glycogen (starch) synthase activity
GFS33_RS12385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFS33_RS12395	COG0469	pyruvate kinase activity
GFS33_RS12405	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GFS33_RS12415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFS33_RS12425	COG0528	UMP kinase activity
GFS33_RS12435	COG1028	Short-chain dehydrogenase reductase Sdr
GFS33_RS12450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFS33_RS12455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFS33_RS12495	COG1110	DNA topoisomerase II activity
GFS33_RS12535	COG0154	amidase activity
GFS33_RS12550	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GFS33_RS12550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GFS33_RS12570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GFS33_RS12605	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
GFS33_RS12635	COG0252	asparaginase activity
GFS33_RS12640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFS33_RS12685	COG0396	ATPase activity
GFS33_RS12705	COG0509	glycine decarboxylation via glycine cleavage system
GFS33_RS12710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GFS33_RS12720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFS33_RS12760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS33_RS12780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFS33_RS12785	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
GFS33_RS12815	COG0644	oxidoreductase
GFS33_RS12825	COG0436	Aminotransferase
GFS33_RS12835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFS33_RS12835	COG0512	Glutamine amidotransferase of anthranilate synthase
GFS33_RS12840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFS33_RS12860	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GFS33_RS12865	COG1254	Belongs to the acylphosphatase family
GFS33_RS12870	COG1260	myo-inositol-1-phosphate synthase
GFS33_RS12880	COG0574	Belongs to the PEP-utilizing enzyme family
GFS33_RS12880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFS33_RS12900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GFS33_RS12905	COG0460	homoserine dehydrogenase
GFS33_RS12905	COG0527	aspartate kinase activity
GFS33_RS12925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFS33_RS12960	COG0459	protein refolding
GFS33_RS13015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFS33_RS13075	COG0315	cyclic pyranopterin monophosphate synthase activity
GFS33_RS13080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFS33_RS13090	COG1881	PFAM PEBP family protein
GFS33_RS13095	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GFS33_RS13105	COG1063	alcohol dehydrogenase
GFS33_RS13130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GFS33_RS13140	COG1047	Peptidyl-prolyl cis-trans
GFS33_RS13160	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GFS33_RS13225	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GFS33_RS13260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFS33_RS13265	COG2264	protein methyltransferase activity
GFS33_RS13270	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GFS33_RS13280	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GFS33_RS13325	COG1185	polyribonucleotide nucleotidyltransferase activity
GFS33_RS13360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFS33_RS13380	COG0473	3-isopropylmalate dehydrogenase activity
GFS33_RS13395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GFS33_RS13410	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFS33_RS13415	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFS33_RS13425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GFS33_RS13430	COG0255	Belongs to the universal ribosomal protein uL29 family
GFS33_RS13440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFS33_RS13445	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GFS33_RS13450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GFS33_RS13460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFS33_RS13470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFS33_RS13475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GFS33_RS13495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFS33_RS13560	COG1136	(ABC) transporter
GFS33_RS13570	COG0577	efflux transmembrane transporter activity
GFS33_RS13570	COG1136	(ABC) transporter