locus-tag	class	description
GFS03_RS00055	COG3383	formate dehydrogenase (NAD+) activity
GFS03_RS00065	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GFS03_RS00070	COG0574	Belongs to the PEP-utilizing enzyme family
GFS03_RS00070	COG3848	Pyruvate phosphate dikinase
GFS03_RS00080	COG0644	oxidoreductase
GFS03_RS00085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GFS03_RS00090	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFS03_RS00095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GFS03_RS00095	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFS03_RS00125	COG0318	PFAM AMP-dependent synthetase and ligase
GFS03_RS00145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GFS03_RS00165	COG1063	alcohol dehydrogenase
GFS03_RS00190	COG0668	transmembrane transport
GFS03_RS00195	COG0586	Pfam SNARE associated Golgi protein
GFS03_RS00200	COG0022	dehydrogenase e1 component
GFS03_RS00205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFS03_RS00210	COG0656	L-ascorbic acid biosynthetic process
GFS03_RS00215	COG0589	response to stress
GFS03_RS00235	COG0438	transferase activity, transferring glycosyl groups
GFS03_RS00240	COG0028	Belongs to the TPP enzyme family
GFS03_RS00255	COG0402	S-adenosylhomocysteine deaminase activity
GFS03_RS00280	COG0492	ferredoxin-NADP+ reductase activity
GFS03_RS00290	COG2086	electron transfer activity
GFS03_RS00300	COG1960	acyl-CoA dehydrogenase activity
GFS03_RS00315	COG0437	4 iron, 4 sulfur cluster binding
GFS03_RS00320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GFS03_RS00325	COG1144	Oxidoreductase
GFS03_RS00330	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFS03_RS00335	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFS03_RS00340	COG0438	transferase activity, transferring glycosyl groups
GFS03_RS00345	COG3387	PFAM Glycoside hydrolase 15-related
GFS03_RS00405	COG3387	PFAM Glycoside hydrolase 15-related
GFS03_RS00415	COG0517	IMP dehydrogenase activity
GFS03_RS00425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFS03_RS00495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFS03_RS00510	COG2814	Major facilitator Superfamily
GFS03_RS00535	COG2259	Doxx family
GFS03_RS00540	COG1702	phosphate starvation-inducible protein PhoH
GFS03_RS00545	COG0813	purine-nucleoside phosphorylase activity
GFS03_RS00550	COG3386	PFAM SMP-30 Gluconolaconase
GFS03_RS00555	COG2814	Major facilitator Superfamily
GFS03_RS00595	COG0183	Belongs to the thiolase family
GFS03_RS00600	COG4274	PFAM GYD family protein
GFS03_RS00605	COG0501	Belongs to the peptidase M48B family
GFS03_RS00610	COG4946	Tricorn protease homolog
GFS03_RS00610	COG1506	peptidase
GFS03_RS00610	COG0823	Involved in the tonB-independent uptake of proteins
GFS03_RS00625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS03_RS00670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GFS03_RS00715	COG4608	Belongs to the ABC transporter superfamily
GFS03_RS00720	COG0444	Belongs to the ABC transporter superfamily
GFS03_RS00735	COG0601	transmembrane transport
GFS03_RS00750	COG4948	Mandelate Racemase Muconate Lactonizing
GFS03_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
GFS03_RS00775	COG0723	plastoquinol--plastocyanin reductase activity
GFS03_RS00815	COG2217	Heavy metal translocating P-type atpase
GFS03_RS00825	COG4555	ABC transporter
GFS03_RS00850	COG1592	Rubrerythrin
GFS03_RS00925	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GFS03_RS00935	COG0183	Belongs to the thiolase family
GFS03_RS00945	COG1024	Enoyl-CoA hydratase
GFS03_RS00985	COG4608	Belongs to the ABC transporter superfamily
GFS03_RS01005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFS03_RS01010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFS03_RS01030	COG0438	transferase activity, transferring glycosyl groups
GFS03_RS01045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GFS03_RS01070	COG1131	(ABC) transporter
GFS03_RS01075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GFS03_RS01080	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GFS03_RS01110	COG0149	triose-phosphate isomerase activity
GFS03_RS01125	COG0372	Belongs to the citrate synthase family
GFS03_RS01130	COG0517	IMP dehydrogenase activity
GFS03_RS01130	COG0516	GMP reductase activity
GFS03_RS01135	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GFS03_RS01140	COG2079	MmgE PrpD family protein
GFS03_RS01145	COG0039	L-malate dehydrogenase activity
GFS03_RS01150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFS03_RS01230	COG0778	Nitroreductase
GFS03_RS01235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS03_RS01385	COG0561	phosphatase activity
GFS03_RS01390	COG2264	protein methyltransferase activity
GFS03_RS01395	COG1011	Hydrolase
GFS03_RS01450	COG0494	nUDIX hydrolase
GFS03_RS01455	COG3253	May function as heme-dependent peroxidase
GFS03_RS01470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFS03_RS01475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFS03_RS01475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFS03_RS01500	COG2226	methyltransferase
GFS03_RS01535	COG0538	isocitrate dehydrogenase activity
GFS03_RS01545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS03_RS01560	COG2154	pterin-4-alpha-carbinolamine dehydratase
GFS03_RS01640	COG1331	Highly conserved protein containing a thioredoxin domain
GFS03_RS01650	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GFS03_RS01660	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GFS03_RS01685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GFS03_RS01700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS03_RS01710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFS03_RS01715	COG2814	Major facilitator Superfamily
GFS03_RS01725	COG0492	ferredoxin-NADP+ reductase activity
GFS03_RS01800	COG0588	phosphoglycerate mutase activity
GFS03_RS01820	COG1957	nucleoside hydrolase
GFS03_RS01835	COG2226	methyltransferase
GFS03_RS01870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFS03_RS01870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GFS03_RS01875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFS03_RS01880	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
GFS03_RS01925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFS03_RS01965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFS03_RS01970	COG1573	uracil-dna glycosylase
GFS03_RS01975	COG1028	Short-chain dehydrogenase reductase Sdr
GFS03_RS02000	COG0215	cysteine-tRNA ligase activity
GFS03_RS02005	COG2222	sugar isomerase
GFS03_RS02015	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFS03_RS02025	COG0433	COG0433 Predicted ATPase
GFS03_RS02035	COG1607	acyl-coa hydrolase
GFS03_RS02045	COG1028	Short-chain dehydrogenase reductase Sdr
GFS03_RS02050	COG0708	Exodeoxyribonuclease III
GFS03_RS02055	COG2815	serine threonine protein kinase
GFS03_RS02055	COG0515	serine threonine protein kinase
GFS03_RS02125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFS03_RS02245	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GFS03_RS02250	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GFS03_RS02265	COG0189	ligase activity
GFS03_RS02305	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GFS03_RS02345	COG2304	oxidoreductase activity
GFS03_RS02350	COG0714	Associated with various cellular activities
GFS03_RS02370	COG0083	homoserine kinase activity
GFS03_RS02375	COG0626	cystathionine gamma-synthase activity
GFS03_RS02415	COG0183	Belongs to the thiolase family
GFS03_RS02420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFS03_RS02460	COG1215	transferase activity, transferring glycosyl groups
GFS03_RS02475	COG0351	phosphomethylpyrimidine kinase
GFS03_RS02480	COG0314	molybdopterin synthase activity
GFS03_RS02505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GFS03_RS02515	COG1131	(ABC) transporter
GFS03_RS02540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFS03_RS02545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFS03_RS02575	COG0720	synthase
GFS03_RS02590	COG0492	ferredoxin-NADP+ reductase activity
GFS03_RS02600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS03_RS02620	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFS03_RS02620	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFS03_RS02630	COG0071	Belongs to the small heat shock protein (HSP20) family
GFS03_RS02695	COG0402	S-adenosylhomocysteine deaminase activity
GFS03_RS02720	COG0430	RNA-3'-phosphate cyclase activity
GFS03_RS02730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFS03_RS02735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFS03_RS02740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS03_RS02750	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GFS03_RS02755	COG5599	Phosphatase
GFS03_RS02760	COG1515	deoxyribonuclease V activity
GFS03_RS02800	COG4581	dead DEAH box helicase
GFS03_RS02810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFS03_RS02820	COG0439	Biotin carboxylase
GFS03_RS02830	COG1116	anion transmembrane transporter activity
GFS03_RS02840	COG0066	3-isopropylmalate dehydratase activity
GFS03_RS02845	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFS03_RS02850	COG0415	Belongs to the DNA photolyase family
GFS03_RS02895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GFS03_RS02915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFS03_RS02920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFS03_RS02935	COG0045	succinate-CoA ligase (ADP-forming) activity
GFS03_RS02990	COG0657	acetylesterase activity
GFS03_RS02995	COG1063	alcohol dehydrogenase
GFS03_RS03000	COG0183	Belongs to the thiolase family
GFS03_RS03005	COG1960	acyl-CoA dehydrogenase activity
GFS03_RS03010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFS03_RS03015	COG1028	Short-chain dehydrogenase reductase Sdr
GFS03_RS03040	COG2814	Major facilitator Superfamily
GFS03_RS03045	COG1309	transcriptional regulator
GFS03_RS03065	COG0318	PFAM AMP-dependent synthetase and ligase
GFS03_RS03070	COG1960	acyl-CoA dehydrogenase activity
GFS03_RS03075	COG1024	Enoyl-CoA hydratase
GFS03_RS03080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFS03_RS03105	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFS03_RS03110	COG0657	acetylesterase activity
GFS03_RS03120	COG0318	PFAM AMP-dependent synthetase and ligase
GFS03_RS03130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GFS03_RS03140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFS03_RS03145	COG0477	Major facilitator Superfamily
GFS03_RS03155	COG1131	(ABC) transporter
GFS03_RS03195	COG1012	belongs to the aldehyde dehydrogenase family
GFS03_RS03210	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GFS03_RS03220	COG1024	Enoyl-CoA hydratase
GFS03_RS03225	COG0500	methyltransferase
GFS03_RS03235	COG0432	Pfam Uncharacterised protein family UPF0047
GFS03_RS03250	COG1305	Transglutaminase-like
GFS03_RS03265	COG1522	sequence-specific DNA binding
GFS03_RS03270	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFS03_RS03275	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFS03_RS03290	COG1620	l-lactate permease
GFS03_RS03300	COG0450	alkyl hydroperoxide reductase
GFS03_RS03325	COG1122	ATPase activity
GFS03_RS03355	COG1335	isochorismatase
GFS03_RS03395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFS03_RS03400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFS03_RS03410	COG2062	phosphohistidine phosphatase, SixA
GFS03_RS03420	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFS03_RS03425	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFS03_RS03460	COG0277	FAD linked oxidase domain protein
GFS03_RS03465	COG0675	Transposase, IS605 OrfB family
GFS03_RS03480	COG1012	belongs to the aldehyde dehydrogenase family
GFS03_RS03490	COG1063	alcohol dehydrogenase
GFS03_RS03525	COG3350	monooxygenase activity
GFS03_RS03550	COG2151	metal-sulfur cluster biosynthetic enzyme
GFS03_RS03555	COG0028	Belongs to the TPP enzyme family
GFS03_RS03620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GFS03_RS03640	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFS03_RS03640	COG3608	succinylglutamate desuccinylase aspartoacylase
GFS03_RS03680	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GFS03_RS03680	COG2050	protein possibly involved in aromatic compounds catabolism
GFS03_RS03685	COG2301	Belongs to the HpcH HpaI aldolase family
GFS03_RS03690	COG1802	Transcriptional regulator
GFS03_RS03720	COG2721	sulfolactate sulfo-lyase activity
GFS03_RS03725	COG2721	sulfolactate sulfo-lyase activity
GFS03_RS03750	COG1131	(ABC) transporter
GFS03_RS03755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFS03_RS03770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFS03_RS03785	COG0601	transmembrane transport
GFS03_RS03795	COG0444	Belongs to the ABC transporter superfamily
GFS03_RS03800	COG4608	Belongs to the ABC transporter superfamily
GFS03_RS03855	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GFS03_RS03855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFS03_RS03900	COG2217	Heavy metal translocating P-type atpase
GFS03_RS03945	COG0675	Transposase, IS605 OrfB family
GFS03_RS03980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFS03_RS03985	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GFS03_RS04010	COG2192	nodulation
GFS03_RS04030	COG0463	Glycosyl transferase, family 2
GFS03_RS04060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFS03_RS04075	COG2723	6-phospho-beta-galactosidase activity
GFS03_RS04185	COG1373	ATPase (AAA superfamily
GFS03_RS04255	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GFS03_RS04260	COG2224	Isocitrate lyase
GFS03_RS04275	COG0675	Transposase, IS605 OrfB family
GFS03_RS04315	COG1215	transferase activity, transferring glycosyl groups
GFS03_RS04385	COG1473	amidohydrolase
GFS03_RS04410	COG1401	restriction endodeoxyribonuclease activity
GFS03_RS04415	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GFS03_RS04420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFS03_RS04435	COG2814	Major facilitator Superfamily
GFS03_RS04470	COG2308	Evidence 4 Homologs of previously reported genes of
GFS03_RS04500	COG1953	Uracil, thiamine, allantoin
GFS03_RS04555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFS03_RS04560	COG0477	Major facilitator Superfamily
GFS03_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
GFS03_RS04580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GFS03_RS04610	COG1131	(ABC) transporter
GFS03_RS04660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFS03_RS04765	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GFS03_RS04950	COG1203	CRISPR-associated helicase, Cas3
GFS03_RS04995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS03_RS05095	COG2084	Dehydrogenase
GFS03_RS05110	COG2186	Transcriptional regulator
GFS03_RS05115	COG0154	amidase activity
GFS03_RS05135	COG4638	Rieske (2fe-2S)
GFS03_RS05140	COG4638	Rieske (2fe-2S)
GFS03_RS05145	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GFS03_RS05155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GFS03_RS05170	COG0477	Major facilitator Superfamily
GFS03_RS05175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFS03_RS05180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GFS03_RS05225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS03_RS05310	COG0243	molybdopterin cofactor binding
GFS03_RS05335	COG0318	PFAM AMP-dependent synthetase and ligase
GFS03_RS05405	COG0675	Transposase, IS605 OrfB family
GFS03_RS05435	COG2002	toxin-antitoxin pair type II binding
GFS03_RS05455	COG1454	alcohol dehydrogenase
GFS03_RS05465	COG1028	Short-chain dehydrogenase reductase Sdr
GFS03_RS05475	COG0535	radical SAM domain protein
GFS03_RS05480	COG0535	radical SAM domain protein
GFS03_RS05485	COG1012	belongs to the aldehyde dehydrogenase family
GFS03_RS05490	COG0519	Catalyzes the synthesis of GMP from XMP
GFS03_RS05500	COG0501	Belongs to the peptidase M48B family
GFS03_RS05505	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GFS03_RS05520	COG0589	response to stress
GFS03_RS05525	COG2151	metal-sulfur cluster biosynthetic enzyme
GFS03_RS05580	COG1136	(ABC) transporter
GFS03_RS05580	COG0577	efflux transmembrane transporter activity
GFS03_RS05625	COG2223	nitrite transmembrane transporter activity
GFS03_RS05630	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GFS03_RS05635	COG1140	nitrate reductase beta subunit
GFS03_RS05640	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GFS03_RS05645	COG2181	nitrate reductase activity
GFS03_RS05675	COG0425	Belongs to the sulfur carrier protein TusA family
GFS03_RS05700	COG1024	Enoyl-CoA hydratase
GFS03_RS05765	COG2226	methyltransferase
GFS03_RS05770	COG1011	Hydrolase
GFS03_RS05795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS03_RS05800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFS03_RS05835	COG0477	Major facilitator Superfamily
GFS03_RS05845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS03_RS05850	COG1953	Uracil, thiamine, allantoin
GFS03_RS05855	COG0531	amino acid
GFS03_RS05860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFS03_RS05870	COG2814	Major facilitator Superfamily
GFS03_RS05910	COG2368	4-hydroxyphenylacetate
GFS03_RS05920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFS03_RS05935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS03_RS05940	COG1960	acyl-CoA dehydrogenase activity
GFS03_RS05950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFS03_RS05980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS03_RS05985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GFS03_RS06000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFS03_RS06050	COG0412	Dienelactone hydrolase
GFS03_RS06090	COG0675	Transposase, IS605 OrfB family
GFS03_RS06100	COG0793	Belongs to the peptidase S41A family
GFS03_RS06100	COG4946	Tricorn protease homolog
GFS03_RS06105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GFS03_RS06110	COG0531	amino acid
GFS03_RS06130	COG0436	Aminotransferase
GFS03_RS06145	COG0530	calcium, potassium:sodium antiporter activity
GFS03_RS06165	COG1175	transmembrane transport
GFS03_RS06170	COG3833	ABC-type maltose transport systems, permease component
GFS03_RS06175	COG3842	ATPase activity
GFS03_RS06185	COG2814	Major facilitator Superfamily
GFS03_RS06195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFS03_RS06215	COG1960	acyl-CoA dehydrogenase activity
GFS03_RS06250	COG0477	Major facilitator Superfamily
GFS03_RS06255	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GFS03_RS06260	COG1131	(ABC) transporter
GFS03_RS06285	COG0475	glutathione-regulated potassium exporter activity
GFS03_RS06300	COG2048	Heterodisulfide reductase, subunit B
GFS03_RS06315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS03_RS06330	COG0425	Belongs to the sulfur carrier protein TusA family
GFS03_RS06335	COG2210	Belongs to the sulfur carrier protein TusA family
GFS03_RS06345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS03_RS06390	COG0095	Lipoate-protein ligase
GFS03_RS06395	COG1832	CoA-binding protein
GFS03_RS06430	COG0509	glycine decarboxylation via glycine cleavage system
GFS03_RS06440	COG2271	Major facilitator Superfamily
GFS03_RS06480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GFS03_RS06525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GFS03_RS06535	COG1846	Transcriptional regulator
GFS03_RS06540	COG0577	efflux transmembrane transporter activity
GFS03_RS06540	COG1136	(ABC) transporter
GFS03_RS06550	COG1136	(ABC) transporter
GFS03_RS06555	COG0114	fumarate hydratase activity
GFS03_RS06565	COG0517	IMP dehydrogenase activity
GFS03_RS06570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GFS03_RS06570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GFS03_RS06575	COG0693	protein deglycase activity
GFS03_RS06585	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFS03_RS06590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFS03_RS06610	COG0509	glycine decarboxylation via glycine cleavage system
GFS03_RS06615	COG0095	Lipoate-protein ligase
GFS03_RS06645	COG0004	ammonium transporteR
GFS03_RS06670	COG1185	polyribonucleotide nucleotidyltransferase activity
GFS03_RS06715	COG1234	tRNA 3'-trailer cleavage
GFS03_RS06730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GFS03_RS06760	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GFS03_RS06770	COG0300	oxidoreductase activity
GFS03_RS06785	COG0650	Formate hydrogenlyase subunit 4
GFS03_RS06795	COG0651	ATP synthesis coupled electron transport
GFS03_RS06805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS03_RS06810	COG0651	ATP synthesis coupled electron transport
GFS03_RS06820	COG2897	thiosulfate sulfurtransferase activity
GFS03_RS06825	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GFS03_RS06895	COG3842	ATPase activity
GFS03_RS06900	COG0395	ABC-type sugar transport system, permease component
GFS03_RS06915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GFS03_RS06920	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GFS03_RS06925	COG0157	Belongs to the NadC ModD family
GFS03_RS06955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GFS03_RS06965	COG0297	glycogen (starch) synthase activity
GFS03_RS06975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFS03_RS06985	COG0469	pyruvate kinase activity
GFS03_RS06995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GFS03_RS07005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFS03_RS07015	COG0528	UMP kinase activity
GFS03_RS07025	COG1028	Short-chain dehydrogenase reductase Sdr
GFS03_RS07040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFS03_RS07045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFS03_RS07055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFS03_RS07085	COG1110	DNA topoisomerase II activity
GFS03_RS07125	COG0154	amidase activity
GFS03_RS07140	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GFS03_RS07140	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GFS03_RS07160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GFS03_RS07195	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
GFS03_RS07225	COG0252	asparaginase activity
GFS03_RS07230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFS03_RS07275	COG0396	ATPase activity
GFS03_RS07295	COG0509	glycine decarboxylation via glycine cleavage system
GFS03_RS07310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFS03_RS07350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS03_RS07355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFS03_RS07370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GFS03_RS07375	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
GFS03_RS07405	COG0644	oxidoreductase
GFS03_RS07415	COG0436	Aminotransferase
GFS03_RS07425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFS03_RS07425	COG0512	Glutamine amidotransferase of anthranilate synthase
GFS03_RS07430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFS03_RS07435	COG0135	phosphoribosylanthranilate isomerase activity
GFS03_RS07445	COG0159	tryptophan synthase activity
GFS03_RS07450	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
GFS03_RS07455	COG1254	Belongs to the acylphosphatase family
GFS03_RS07460	COG1260	myo-inositol-1-phosphate synthase
GFS03_RS07470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFS03_RS07470	COG0574	Belongs to the PEP-utilizing enzyme family
GFS03_RS07490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GFS03_RS07495	COG0460	homoserine dehydrogenase
GFS03_RS07495	COG0527	aspartate kinase activity
GFS03_RS07515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFS03_RS07550	COG0459	protein refolding
GFS03_RS07610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFS03_RS07670	COG0315	cyclic pyranopterin monophosphate synthase activity
GFS03_RS07675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFS03_RS07685	COG1881	PFAM PEBP family protein
GFS03_RS07690	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GFS03_RS07725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GFS03_RS07735	COG1047	Peptidyl-prolyl cis-trans
GFS03_RS07755	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GFS03_RS07800	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GFS03_RS07835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFS03_RS07840	COG2264	protein methyltransferase activity
GFS03_RS07845	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GFS03_RS07855	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GFS03_RS07900	COG1185	polyribonucleotide nucleotidyltransferase activity
GFS03_RS07935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFS03_RS07955	COG0473	3-isopropylmalate dehydrogenase activity
GFS03_RS07970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GFS03_RS07985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFS03_RS07990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFS03_RS08000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GFS03_RS08005	COG0255	Belongs to the universal ribosomal protein uL29 family
GFS03_RS08015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFS03_RS08020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GFS03_RS08025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GFS03_RS08035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFS03_RS08045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFS03_RS08050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GFS03_RS08070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFS03_RS08325	COG1136	(ABC) transporter
GFS03_RS08335	COG1136	(ABC) transporter
GFS03_RS08335	COG0577	efflux transmembrane transporter activity
GFS03_RS08345	COG0069	glutamate synthase activity
GFS03_RS08350	COG0067	glutamate synthase
GFS03_RS08365	COG0402	S-adenosylhomocysteine deaminase activity
GFS03_RS08375	COG0746	molybdenum cofactor guanylyltransferase activity
GFS03_RS08380	COG0303	'Molybdopterin
GFS03_RS08425	COG2379	hydroxypyruvate reductase
GFS03_RS08430	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS03_RS08435	COG0009	L-threonylcarbamoyladenylate synthase
GFS03_RS08440	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GFS03_RS08440	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GFS03_RS08450	COG0312	modulator of DNA gyrase
GFS03_RS08455	COG0864	Transcriptional regulator
GFS03_RS08465	COG0460	homoserine dehydrogenase
GFS03_RS08470	COG0109	protoheme IX farnesyltransferase activity
GFS03_RS08480	COG1024	Enoyl-CoA hydratase
GFS03_RS08515	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFS03_RS08525	COG0189	ligase activity
GFS03_RS08540	COG0165	Argininosuccinate lyase
GFS03_RS08545	COG0137	argininosuccinate synthase activity
GFS03_RS08560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GFS03_RS08565	COG0151	Belongs to the GarS family
GFS03_RS08570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GFS03_RS08575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GFS03_RS08580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFS03_RS08585	COG0047	phosphoribosylformylglycinamidine synthase activity
GFS03_RS08595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFS03_RS08600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFS03_RS08600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFS03_RS08605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFS03_RS08610	COG0602	queuosine metabolic process
GFS03_RS08645	COG0284	orotidine-5'-phosphate decarboxylase activity
GFS03_RS08650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GFS03_RS08660	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GFS03_RS08670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFS03_RS08675	COG0167	dihydroorotate dehydrogenase activity
GFS03_RS08690	COG2095	MarC family integral membrane protein
GFS03_RS08695	COG1522	sequence-specific DNA binding
GFS03_RS08710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFS03_RS08715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFS03_RS08720	COG2151	metal-sulfur cluster biosynthetic enzyme
GFS03_RS08730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFS03_RS08735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GFS03_RS08735	COG0140	phosphoribosyl-ATP diphosphatase activity
GFS03_RS08740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GFS03_RS08745	COG0107	imidazoleglycerol-phosphate synthase activity
GFS03_RS08750	COG0131	Imidazoleglycerol-phosphate dehydratase
GFS03_RS08755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GFS03_RS08760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GFS03_RS08765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFS03_RS08775	COG0495	leucyl-tRNA aminoacylation
GFS03_RS08780	COG2096	Adenosyltransferase
GFS03_RS08785	COG0037	tRNA processing
GFS03_RS08795	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GFS03_RS08820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GFS03_RS08830	COG0028	Belongs to the TPP enzyme family
GFS03_RS08840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFS03_RS08855	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GFS03_RS08860	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GFS03_RS08870	COG0442	prolyl-tRNA aminoacylation
GFS03_RS08885	COG1394	ATPase activity, coupled to movement of substances
GFS03_RS08895	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GFS03_RS08915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFS03_RS08945	COG0417	DNA replication proofreading
GFS03_RS08970	COG0126	phosphoglycerate kinase activity
GFS03_RS08980	COG0589	response to stress
GFS03_RS08985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFS03_RS09005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFS03_RS09010	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GFS03_RS09065	COG0495	leucyl-tRNA aminoacylation
GFS03_RS09115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFS03_RS09130	COG1121	(ABC) transporter
GFS03_RS09145	COG0805	protein transport
GFS03_RS09155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFS03_RS09170	COG2226	methyltransferase
GFS03_RS09180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFS03_RS09190	COG0556	nucleotide-excision repair
GFS03_RS09195	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GFS03_RS09205	COG3276	selenocysteine insertion sequence binding
GFS03_RS09225	COG0351	phosphomethylpyrimidine kinase
GFS03_RS09225	COG1992	Thiamine-phosphate synthase
GFS03_RS09255	COG0489	protein tyrosine kinase activity
GFS03_RS09275	COG1280	lysine exporter protein (LysE YggA)
GFS03_RS09290	COG0180	Tryptophanyl-tRNA synthetase
GFS03_RS09305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFS03_RS09350	COG0010	Belongs to the arginase family
GFS03_RS09355	COG0423	glycine-tRNA ligase activity
GFS03_RS09385	COG0163	prenyltransferase activity
GFS03_RS09395	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
GFS03_RS09420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFS03_RS09425	COG0667	Aldo Keto reductase
GFS03_RS09470	COG1110	DNA topoisomerase II activity
GFS03_RS09475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS03_RS09480	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GFS03_RS09525	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFS03_RS09540	COG1797	cobyrinic acid a,c-diamide synthase activity
GFS03_RS09560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GFS03_RS09570	COG0402	S-adenosylhomocysteine deaminase activity
GFS03_RS09590	COG1201	RNA secondary structure unwinding
GFS03_RS09600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFS03_RS09605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFS03_RS09610	COG2813	Specifically methylates the guanine in position
GFS03_RS09620	COG1444	tRNA N-acetyltransferase activity
GFS03_RS09655	COG1215	transferase activity, transferring glycosyl groups
GFS03_RS09675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFS03_RS09680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFS03_RS09690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFS03_RS09720	COG4974	Belongs to the 'phage' integrase family
GFS03_RS09725	COG0535	radical SAM domain protein
GFS03_RS09730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GFS03_RS09735	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GFS03_RS09735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFS03_RS09745	COG0318	PFAM AMP-dependent synthetase and ligase
GFS03_RS09750	COG3118	belongs to the thioredoxin family
GFS03_RS09755	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GFS03_RS09770	COG0302	gtp cyclohydrolase
GFS03_RS09780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GFS03_RS09795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFS03_RS09860	COG0552	protein localization to endoplasmic reticulum
GFS03_RS09875	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFS03_RS09885	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFS03_RS09895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFS03_RS09925	COG0301	tRNA thio-modification
GFS03_RS09930	COG1260	myo-inositol-1-phosphate synthase
GFS03_RS09935	COG1007	ATP synthesis coupled electron transport
GFS03_RS09940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFS03_RS09945	COG0713	ATP synthesis coupled electron transport
GFS03_RS09955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS03_RS09960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GFS03_RS09965	COG0649	NAD binding
GFS03_RS09970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFS03_RS09980	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GFS03_RS10000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GFS03_RS10045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GFS03_RS10055	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GFS03_RS10060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFS03_RS10065	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GFS03_RS10070	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GFS03_RS10075	COG1605	Chorismate mutase
GFS03_RS10075	COG0077	Prephenate dehydratase
GFS03_RS10080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFS03_RS10085	COG3959	Transketolase, thiamine diphosphate binding domain
GFS03_RS10090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GFS03_RS10110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GFS03_RS10145	COG0477	Major facilitator Superfamily
GFS03_RS10155	COG1121	(ABC) transporter
GFS03_RS10160	COG1980	fructose-bisphosphate aldolase activity
GFS03_RS10185	COG0459	protein refolding
GFS03_RS10200	COG0124	histidyl-tRNA synthetase
GFS03_RS10235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS03_RS10245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFS03_RS10290	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GFS03_RS10340	COG1056	cytidyltransferase-related domain
GFS03_RS10340	COG1051	belongs to the nudix hydrolase family
GFS03_RS10355	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GFS03_RS10355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFS03_RS10380	COG1605	Chorismate mutase
GFS03_RS10380	COG0077	Prephenate dehydratase
GFS03_RS10395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFS03_RS10410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GFS03_RS10425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GFS03_RS10440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFS03_RS10445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFS03_RS10450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GFS03_RS10465	COG0105	UTP biosynthetic process
GFS03_RS10480	COG0085	RNA polymerase activity
GFS03_RS10485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFS03_RS10490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFS03_RS10515	COG0049	tRNA binding
GFS03_RS10520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GFS03_RS10525	COG0051	transcription antitermination factor activity, RNA binding
GFS03_RS10570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GFS03_RS10580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFS03_RS10600	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GFS03_RS10605	COG0504	CTP synthase activity
GFS03_RS10620	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
GFS03_RS10650	COG2078	PFAM AMMECR1 domain protein
GFS03_RS10665	COG0717	Belongs to the dCTP deaminase family
GFS03_RS10670	COG1793	dna ligase
GFS03_RS10680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFS03_RS10705	COG0181	hydroxymethylbilane synthase activity
GFS03_RS10710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFS03_RS10715	COG0113	porphobilinogen synthase activity
GFS03_RS10720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GFS03_RS10740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFS03_RS10760	COG0585	pseudouridine synthase activity
GFS03_RS10765	COG0017	Asparaginyl-tRNA synthetase
GFS03_RS10790	COG0028	Belongs to the TPP enzyme family
GFS03_RS10805	COG1129	ABC transporter
GFS03_RS10830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFS03_RS10835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFS03_RS10840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFS03_RS10845	COG0189	ligase activity
GFS03_RS10860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GFS03_RS10865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GFS03_RS10880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GFS03_RS10945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFS03_RS10950	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GFS03_RS10965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFS03_RS10965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFS03_RS11000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFS03_RS11015	COG1201	RNA secondary structure unwinding
GFS03_RS11025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFS03_RS11025	COG0617	tRNA 3'-terminal CCA addition
GFS03_RS11025	COG0517	IMP dehydrogenase activity
GFS03_RS11050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFS03_RS11055	COG1546	Belongs to the CinA family
GFS03_RS11055	COG1058	Belongs to the CinA family
GFS03_RS11075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFS03_RS11100	COG1078	dGTPase activity
GFS03_RS11105	COG0561	phosphatase activity
GFS03_RS11125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFS03_RS11155	COG0454	-acetyltransferase
GFS03_RS11170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFS03_RS11185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFS03_RS11190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFS03_RS11195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFS03_RS11210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFS03_RS11215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFS03_RS11225	COG0052	Belongs to the universal ribosomal protein uS2 family
GFS03_RS11230	COG1355	regulation of microtubule-based process
GFS03_RS11245	COG1304	FMN binding
GFS03_RS11315	COG1695	Transcriptional regulator
GFS03_RS11330	COG0084	hydrolase, TatD family'
GFS03_RS11350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFS03_RS11380	COG1192	Involved in chromosome partitioning
GFS03_RS11400	COG0617	tRNA 3'-terminal CCA addition
GFS03_RS11400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFS03_RS11400	COG3620	sequence-specific DNA binding
GFS03_RS11410	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GFS03_RS11455	COG1201	RNA secondary structure unwinding
GFS03_RS11510	COG0123	including yeast histone deacetylase and acetoin utilization protein
GFS03_RS11525	COG1234	tRNA 3'-trailer cleavage
GFS03_RS11530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFS03_RS11535	COG0351	phosphomethylpyrimidine kinase
GFS03_RS11545	COG1215	transferase activity, transferring glycosyl groups
GFS03_RS11615	COG1063	alcohol dehydrogenase
GFS03_RS11620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GFS03_RS11635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFS03_RS11635	COG0519	Catalyzes the synthesis of GMP from XMP
GFS03_RS11640	COG0501	Belongs to the peptidase M48B family
GFS03_RS11645	COG0516	GMP reductase activity
GFS03_RS11645	COG0517	IMP dehydrogenase activity
GFS03_RS11655	COG1830	Aldolase
GFS03_RS11680	COG0405	Gamma-glutamyltransferase
GFS03_RS11695	COG1444	tRNA N-acetyltransferase activity
GFS03_RS11710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFS03_RS11720	COG0667	Aldo Keto reductase
GFS03_RS11740	COG0617	tRNA 3'-terminal CCA addition
GFS03_RS11740	COG0517	IMP dehydrogenase activity
GFS03_RS11740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFS03_RS11745	COG1063	alcohol dehydrogenase
GFS03_RS11750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS03_RS11760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFS03_RS11775	COG4948	Mandelate Racemase Muconate Lactonizing
GFS03_RS11780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFS03_RS11785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFS03_RS11790	COG1012	belongs to the aldehyde dehydrogenase family
GFS03_RS11795	COG0530	calcium, potassium:sodium antiporter activity
GFS03_RS11800	COG0243	molybdopterin cofactor binding
GFS03_RS11835	COG0589	response to stress
GFS03_RS11850	COG2814	Major facilitator Superfamily
GFS03_RS11875	COG1733	regulation of RNA biosynthetic process
GFS03_RS11885	COG0517	IMP dehydrogenase activity
GFS03_RS11885	COG0516	GMP reductase activity
GFS03_RS11890	COG1720	tRNA m6t6A37 methyltransferase activity
GFS03_RS11940	COG0277	FAD linked oxidase domain protein
GFS03_RS11945	COG0247	lactate metabolic process
GFS03_RS11950	COG0095	Lipoate-protein ligase
GFS03_RS11955	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFS03_RS11970	COG0655	NAD(P)H dehydrogenase (quinone) activity
GFS03_RS11990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFS03_RS11995	COG0477	Major facilitator Superfamily
GFS03_RS12045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFS03_RS12055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFS03_RS12065	COG1139	Iron-sulfur cluster binding protein
GFS03_RS12070	COG2814	Major facilitator Superfamily
GFS03_RS12095	COG4948	Mandelate Racemase Muconate Lactonizing
GFS03_RS12105	COG0477	Major facilitator Superfamily
GFS03_RS12110	COG2271	Major facilitator Superfamily
GFS03_RS12125	COG2267	carboxylic ester hydrolase activity
GFS03_RS12135	COG1028	Short-chain dehydrogenase reductase Sdr
GFS03_RS12165	COG0805	protein transport
GFS03_RS12180	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GFS03_RS12220	COG1134	teichoic acid transport
GFS03_RS12260	COG0425	Belongs to the sulfur carrier protein TusA family
GFS03_RS12280	COG1121	(ABC) transporter
GFS03_RS12325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFS03_RS12335	COG3842	ATPase activity
GFS03_RS12345	COG1175	transmembrane transport
GFS03_RS12355	COG0318	PFAM AMP-dependent synthetase and ligase
GFS03_RS12395	COG0601	transmembrane transport
GFS03_RS12445	COG0673	inositol 2-dehydrogenase activity
GFS03_RS12465	COG4608	Belongs to the ABC transporter superfamily
GFS03_RS12480	COG3386	PFAM SMP-30 Gluconolaconase
GFS03_RS12495	COG3250	beta-galactosidase activity
GFS03_RS12500	COG4948	Mandelate Racemase Muconate Lactonizing
GFS03_RS12505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFS03_RS12515	COG1472	Belongs to the glycosyl hydrolase 3 family
GFS03_RS12530	COG1073	alpha beta
GFS03_RS12555	COG4948	Mandelate Racemase Muconate Lactonizing
GFS03_RS12560	COG0675	Transposase, IS605 OrfB family
GFS03_RS12575	COG1501	Belongs to the glycosyl hydrolase 31 family
GFS03_RS12585	COG2723	6-phospho-beta-galactosidase activity
GFS03_RS12605	COG0667	Aldo Keto reductase
GFS03_RS12610	COG0673	inositol 2-dehydrogenase activity
GFS03_RS12615	COG1132	(ABC) transporter
GFS03_RS12650	COG1028	Short-chain dehydrogenase reductase Sdr
GFS03_RS12670	COG0459	protein refolding
GFS03_RS12675	COG4948	Mandelate Racemase Muconate Lactonizing
GFS03_RS12680	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFS03_RS12685	COG1914	H( )-stimulated, divalent metal cation uptake system
GFS03_RS12760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GFS03_RS12785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFS03_RS12800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GFS03_RS12800	COG2857	Cytochrome c1
GFS03_RS12890	COG0717	Belongs to the dCTP deaminase family
GFS03_RS12915	COG3473	Maleate cis-trans isomerase
GFS03_RS12935	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
GFS03_RS12970	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GFS03_RS12975	COG1648	precorrin-2 dehydrogenase activity
GFS03_RS12975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFS03_RS12980	COG2897	thiosulfate sulfurtransferase activity
GFS03_RS13035	COG0667	Aldo Keto reductase
GFS03_RS13050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFS03_RS13060	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFS03_RS13060	COG3608	succinylglutamate desuccinylase aspartoacylase
GFS03_RS13070	COG1960	acyl-CoA dehydrogenase activity
GFS03_RS13075	COG0318	PFAM AMP-dependent synthetase and ligase
GFS03_RS13080	COG0183	Belongs to the thiolase family
GFS03_RS13090	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFS03_RS13100	COG0281	malic enzyme
GFS03_RS13130	COG1584	GPR1 FUN34 yaaH family protein
GFS03_RS13135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFS03_RS13175	COG3842	ATPase activity
GFS03_RS13180	COG0395	ABC-type sugar transport system, permease component
GFS03_RS13230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins