locus-tag	class	description
SCD_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SCD_RS00025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SCD_RS00035	COG2922	Belongs to the Smg family
SCD_RS00040	COG0758	DNA mediated transformation
SCD_RS00050	COG0242	peptide deformylase activity
SCD_RS00055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SCD_RS00070	COG5000	phosphorelay sensor kinase activity
SCD_RS00075	COG2204	response regulator
SCD_RS00080	COG3158	transport of potassium into the cell
SCD_RS00095	COG0308	aminopeptidase N
SCD_RS00100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SCD_RS00125	COG1509	lysine 2,3-aminomutase activity
SCD_RS00145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SCD_RS00150	COG0129	dihydroxy-acid dehydratase activity
SCD_RS00155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SCD_RS00160	COG1331	Highly conserved protein containing a thioredoxin domain
SCD_RS00170	COG0733	neurotransmitter:sodium symporter activity
SCD_RS00175	COG1115	amino acid carrier protein
SCD_RS00180	COG0408	coproporphyrinogen oxidase activity
SCD_RS00185	COG0009	L-threonylcarbamoyladenylate synthase
SCD_RS00190	COG0151	Belongs to the GarS family
SCD_RS00200	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
SCD_RS00210	COG2095	MarC family integral membrane protein
SCD_RS00220	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SCD_RS00225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SCD_RS00225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SCD_RS00240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SCD_RS00250	COG0210	DNA helicase
SCD_RS00255	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SCD_RS00260	COG0427	acetyl-CoA hydrolase
SCD_RS00270	COG0495	leucyl-tRNA aminoacylation
SCD_RS00285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SCD_RS00295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SCD_RS00300	COG0799	negative regulation of ribosome biogenesis
SCD_RS00310	COG0424	maF-like protein
SCD_RS00315	COG1530	ribonuclease E activity
SCD_RS00325	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SCD_RS00345	COG1872	DUF167
SCD_RS00350	COG0762	integral membrane protein
SCD_RS00375	COG1022	Amp-dependent synthetase and ligase
SCD_RS00380	COG1981	membrane
SCD_RS00400	COG0189	ligase activity
SCD_RS00415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SCD_RS00420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SCD_RS00425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SCD_RS00440	COG2814	Major facilitator Superfamily
SCD_RS00450	COG0708	Exodeoxyribonuclease III
SCD_RS00455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SCD_RS00465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SCD_RS00470	COG0154	amidase activity
SCD_RS00475	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SCD_RS00480	COG1077	Cell shape determining protein MreB Mrl
SCD_RS00495	COG0768	penicillin binding
SCD_RS00500	COG0772	Belongs to the SEDS family
SCD_RS00510	COG1686	Belongs to the peptidase S11 family
SCD_RS00520	COG2921	Belongs to the UPF0250 family
SCD_RS00525	COG0321	lipoyl(octanoyl) transferase activity
SCD_RS00530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SCD_RS00590	COG0776	regulation of translation
SCD_RS00610	COG2131	deaminase
SCD_RS00615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SCD_RS00690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SCD_RS00695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SCD_RS00695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SCD_RS00705	COG0425	Belongs to the sulfur carrier protein TusA family
SCD_RS00705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SCD_RS00715	COG0730	response to heat
SCD_RS00730	COG0121	glutamine amidotransferase
SCD_RS00735	COG1104	cysteine desulfurase activity
SCD_RS00745	COG3647	Membrane
SCD_RS00775	COG1131	(ABC) transporter
SCD_RS00790	COG0425	Belongs to the sulfur carrier protein TusA family
SCD_RS00800	COG1309	transcriptional regulator
SCD_RS00810	COG0446	pyridine nucleotide-disulphide oxidoreductase
SCD_RS00815	COG0513	Belongs to the DEAD box helicase family
SCD_RS00845	COG1715	Restriction endonuclease
SCD_RS00855	COG0019	diaminopimelate decarboxylase activity
SCD_RS00865	COG1309	transcriptional regulator
SCD_RS00885	COG1131	(ABC) transporter
SCD_RS00890	COG0842	Transport permease protein
SCD_RS00900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SCD_RS00905	COG0306	phosphate transporter
SCD_RS00920	COG1595	DNA-templated transcription, initiation
SCD_RS00935	COG2239	Acts as a magnesium transporter
SCD_RS00940	COG5001	Diguanylate cyclase
SCD_RS00940	COG5002	protein histidine kinase activity
SCD_RS00940	COG3447	MASE1 domain protein
SCD_RS00945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SCD_RS00950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SCD_RS00960	COG0174	glutamine synthetase
SCD_RS00970	COG3852	Histidine kinase
SCD_RS00975	COG2204	response regulator
SCD_RS00995	COG0708	Exodeoxyribonuclease III
SCD_RS01010	COG0339	signal peptide processing
SCD_RS01015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SCD_RS01020	COG0033	Phosphoglucomutase
SCD_RS01040	COG0540	Belongs to the ATCase OTCase family
SCD_RS01045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SCD_RS01050	COG1678	Uncharacterized ACR, COG1678
SCD_RS01060	COG0557	exoribonuclease II activity
SCD_RS01065	COG3150	esterase
SCD_RS01070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SCD_RS01105	COG0646	methionine synthase
SCD_RS01105	COG1410	methionine synthase
SCD_RS01115	COG3706	GGDEF domain
SCD_RS01140	COG0606	chelatase, subunit chli
SCD_RS01190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SCD_RS01195	COG2176	DNA-directed DNA polymerase activity
SCD_RS01315	COG0606	chelatase, subunit chli
SCD_RS01320	COG2960	long-chain fatty acid transporting porin activity
SCD_RS01330	COG0347	Belongs to the P(II) protein family
SCD_RS01360	COG0668	transmembrane transport
SCD_RS01370	COG2264	protein methyltransferase activity
SCD_RS01375	COG1238	metal cluster binding
SCD_RS01380	COG0277	FAD linked oxidase domain protein
SCD_RS01400	COG0745	RESPONSE REGULATOR receiver
SCD_RS01405	COG2226	methyltransferase
SCD_RS01420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SCD_RS01485	COG0058	SHG alpha-glucan phosphorylase activity
SCD_RS01500	COG0672	)-iron permease
SCD_RS01505	COG4633	Protein conserved in bacteria
SCD_RS01520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SCD_RS01525	COG1560	Kdo2-lipid A biosynthetic process
SCD_RS01540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SCD_RS01550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SCD_RS01580	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SCD_RS01585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SCD_RS01600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SCD_RS01605	COG1929	Belongs to the glycerate kinase type-1 family
SCD_RS01615	COG0488	(ABC) transporter
SCD_RS01630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SCD_RS01640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SCD_RS01660	COG4585	Histidine kinase
SCD_RS01665	COG2197	response regulator
SCD_RS01670	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SCD_RS01680	COG0545	Peptidyl-prolyl cis-trans isomerase
SCD_RS01690	COG2197	response regulator
SCD_RS01715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SCD_RS01725	COG4263	nitrous-oxide reductase activity
SCD_RS01750	COG0437	4 iron, 4 sulfur cluster binding
SCD_RS01755	COG3901	Regulator of nitric oxide reductase transcription
SCD_RS01755	COG0348	domain, Protein
SCD_RS01760	COG1122	ATPase activity
SCD_RS01775	COG2226	methyltransferase
SCD_RS01790	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SCD_RS01795	COG0348	domain, Protein
SCD_RS01800	COG0437	4 iron, 4 sulfur cluster binding
SCD_RS01810	COG2010	Cytochrome c
SCD_RS01830	COG3794	PFAM blue (type 1) copper domain protein
SCD_RS01840	COG3391	amine dehydrogenase activity
SCD_RS01845	COG1522	sequence-specific DNA binding
SCD_RS01860	COG0535	radical SAM domain protein
SCD_RS01880	COG0243	molybdopterin cofactor binding
SCD_RS01890	COG2863	cytochrome
SCD_RS01895	COG0446	pyridine nucleotide-disulphide oxidoreductase
SCD_RS01910	COG1328	CTP reductase activity
SCD_RS01910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SCD_RS01915	COG3154	lipid carrier protein
SCD_RS01930	COG0248	Ppx GppA phosphatase
SCD_RS01940	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SCD_RS01950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SCD_RS01960	COG1012	belongs to the aldehyde dehydrogenase family
SCD_RS01970	COG0702	epimerase
SCD_RS01975	COG0617	tRNA 3'-terminal CCA addition
SCD_RS01980	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SCD_RS01985	COG5001	Diguanylate cyclase
SCD_RS01985	COG5002	protein histidine kinase activity
SCD_RS02020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SCD_RS02025	COG1136	(ABC) transporter
SCD_RS02025	COG0577	efflux transmembrane transporter activity
SCD_RS02030	COG0577	efflux transmembrane transporter activity
SCD_RS02030	COG1136	(ABC) transporter
SCD_RS02050	COG0037	tRNA processing
SCD_RS02070	COG5001	Diguanylate cyclase
SCD_RS02070	COG5002	protein histidine kinase activity
SCD_RS02105	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SCD_RS02120	COG0095	Lipoate-protein ligase
SCD_RS02130	COG0433	COG0433 Predicted ATPase
SCD_RS02140	COG0826	peptidase U32
SCD_RS02145	COG0826	peptidase U32
SCD_RS02150	COG1242	4 iron, 4 sulfur cluster binding
SCD_RS02160	COG0515	serine threonine protein kinase
SCD_RS02160	COG2815	serine threonine protein kinase
SCD_RS02165	COG0515	serine threonine protein kinase
SCD_RS02165	COG2815	serine threonine protein kinase
SCD_RS02195	COG2900	Belongs to the SlyX family
SCD_RS02200	COG1959	2 iron, 2 sulfur cluster binding
SCD_RS02230	COG2151	metal-sulfur cluster biosynthetic enzyme
SCD_RS02235	COG2204	response regulator
SCD_RS02255	COG0714	Associated with various cellular activities
SCD_RS02275	COG2010	Cytochrome c
SCD_RS02315	COG2890	protein-(glutamine-N5) methyltransferase activity
SCD_RS02320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SCD_RS02325	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SCD_RS02340	COG0642	Histidine kinase
SCD_RS02350	COG1858	cytochrome C peroxidase
SCD_RS02380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SCD_RS02390	COG0516	GMP reductase activity
SCD_RS02390	COG0517	IMP dehydrogenase activity
SCD_RS02425	COG0459	protein refolding
SCD_RS02430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SCD_RS02440	COG0668	transmembrane transport
SCD_RS02450	COG2951	lytic endotransglycosylase activity
SCD_RS02460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SCD_RS02465	COG2027	D-alanyl-D-alanine carboxypeptidase
SCD_RS02470	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SCD_RS02485	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SCD_RS02510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SCD_RS02515	COG3161	chorismate lyase activity
SCD_RS02520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SCD_RS02535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SCD_RS02540	COG1758	RNA polymerase activity
SCD_RS02545	COG0194	GDP metabolic process
SCD_RS02550	COG1561	YicC-like family, N-terminal region
SCD_RS02555	COG3266	domain, Protein
SCD_RS02555	COG0515	serine threonine protein kinase
SCD_RS02560	COG0631	protein serine/threonine phosphatase activity
SCD_RS02565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SCD_RS02570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SCD_RS02575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SCD_RS02580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SCD_RS02590	COG0302	gtp cyclohydrolase
SCD_RS02620	COG0425	Belongs to the sulfur carrier protein TusA family
SCD_RS02625	COG0778	Nitroreductase
SCD_RS02630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SCD_RS02635	COG2022	thiamine diphosphate biosynthetic process
SCD_RS02645	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SCD_RS02660	COG1194	a g-specific adenine glycosylase
SCD_RS02670	COG0084	hydrolase, TatD family'
SCD_RS02675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SCD_RS02680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SCD_RS02725	COG0163	prenyltransferase activity
SCD_RS02745	COG1660	Displays ATPase and GTPase activities
SCD_RS02750	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SCD_RS02770	COG1137	ATPase activity
SCD_RS02775	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
SCD_RS02785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SCD_RS02830	COG1459	type II secretion system
SCD_RS02835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SCD_RS02850	COG3267	Type II secretory pathway component ExeA
SCD_RS02850	COG3409	Peptidoglycan-binding domain 1 protein
SCD_RS02855	COG1127	ABC transporter
SCD_RS02860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SCD_RS02865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SCD_RS02880	COG1131	(ABC) transporter
SCD_RS02885	COG0842	Transport permease protein
SCD_RS02890	COG0271	Belongs to the BolA IbaG family
SCD_RS02895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SCD_RS02900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SCD_RS02905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SCD_RS02910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SCD_RS02915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SCD_RS02920	COG0131	Imidazoleglycerol-phosphate dehydratase
SCD_RS02925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SCD_RS02930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SCD_RS02935	COG0107	imidazoleglycerol-phosphate synthase activity
SCD_RS02940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SCD_RS02945	COG0140	phosphoribosyl-ATP diphosphatase activity
SCD_RS02955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SCD_RS02960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SCD_RS02975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SCD_RS02980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SCD_RS02985	COG0723	plastoquinol--plastocyanin reductase activity
SCD_RS02990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SCD_RS02995	COG2857	Cytochrome c1
SCD_RS03000	COG0625	glutathione transferase activity
SCD_RS03005	COG2969	positive regulation of protein catabolic process
SCD_RS03030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SCD_RS03040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SCD_RS03050	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SCD_RS03055	COG0081	regulation of translation
SCD_RS03060	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SCD_RS03065	COG0222	ribosome binding
SCD_RS03070	COG0085	RNA polymerase activity
SCD_RS03075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SCD_RS03080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SCD_RS03085	COG0049	tRNA binding
SCD_RS03090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SCD_RS03095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SCD_RS03100	COG0051	transcription antitermination factor activity, RNA binding
SCD_RS03105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SCD_RS03110	COG0088	Forms part of the polypeptide exit tunnel
SCD_RS03115	COG0089	rRNA binding
SCD_RS03120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SCD_RS03125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SCD_RS03130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SCD_RS03135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SCD_RS03145	COG0255	Belongs to the universal ribosomal protein uL29 family
SCD_RS03150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SCD_RS03155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SCD_RS03160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SCD_RS03165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SCD_RS03170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SCD_RS03175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SCD_RS03180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SCD_RS03185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SCD_RS03190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SCD_RS03195	COG1841	ribosomal large subunit assembly
SCD_RS03200	COG0200	Binds to the 23S rRNA
SCD_RS03205	COG0201	protein transport
SCD_RS03210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SCD_RS03215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SCD_RS03220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SCD_RS03225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SCD_RS03230	COG0202	RNA polymerase activity
SCD_RS03235	COG0203	ribosomal protein L17
SCD_RS03245	COG2814	Major facilitator Superfamily
SCD_RS03250	COG0629	single-stranded DNA binding
SCD_RS03255	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SCD_RS03260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SCD_RS03265	COG1393	Belongs to the ArsC family
SCD_RS03300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SCD_RS03305	COG0494	nUDIX hydrolase
SCD_RS03310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SCD_RS03315	COG3568	Endonuclease Exonuclease Phosphatase
SCD_RS03320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SCD_RS03325	COG0217	transcriptional regulatory protein
SCD_RS03330	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SCD_RS03335	COG0632	four-way junction helicase activity
SCD_RS03340	COG2255	four-way junction helicase activity
SCD_RS03345	COG0824	Thioesterase
SCD_RS03365	COG0823	Involved in the tonB-independent uptake of proteins
SCD_RS03380	COG0602	queuosine metabolic process
SCD_RS03385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SCD_RS03385	COG0189	ligase activity
SCD_RS03390	COG0189	ligase activity
SCD_RS03390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SCD_RS03400	COG1132	(ABC) transporter
SCD_RS03440	COG0746	molybdenum cofactor guanylyltransferase activity
SCD_RS03445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SCD_RS03450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SCD_RS03455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SCD_RS03465	COG0356	it plays a direct role in the translocation of protons across the membrane
SCD_RS03485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SCD_RS03495	COG2326	polyphosphate kinase activity
SCD_RS03505	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SCD_RS03510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SCD_RS03530	COG1183	phosphatidylcholine synthase activity
SCD_RS03540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SCD_RS03565	COG4628	conserved protein (DUF2132)
SCD_RS03570	COG3263	regulation of cellular component size
SCD_RS03580	COG2205	protein histidine kinase activity
SCD_RS03580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SCD_RS03590	COG0628	permease
SCD_RS03595	COG2823	Periplasmic or secreted lipoprotein
SCD_RS03645	COG0254	rRNA binding
SCD_RS03650	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SCD_RS03715	COG0756	dUTP diphosphatase activity
SCD_RS03720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SCD_RS03725	COG2003	Belongs to the UPF0758 family
SCD_RS03730	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SCD_RS03735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SCD_RS03740	COG3264	Mechanosensitive ion channel
SCD_RS03740	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SCD_RS03745	COG0598	Magnesium transport protein CorA
SCD_RS03755	COG1122	ATPase activity
SCD_RS03765	COG0310	cobalt ion transport
SCD_RS03780	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SCD_RS03785	COG0437	4 iron, 4 sulfur cluster binding
SCD_RS03790	COG5557	Pfam Polysulphide reductase, NrfD
SCD_RS03795	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SCD_RS03800	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SCD_RS03805	COG0298	carbon dioxide binding
SCD_RS03810	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SCD_RS03815	COG0375	protein maturation
SCD_RS03825	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SCD_RS03830	COG0298	carbon dioxide binding
SCD_RS03835	COG0409	Hydrogenase expression formation protein
SCD_RS03840	COG0309	Hydrogenase expression formation protein (HypE)
SCD_RS03855	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SCD_RS03860	COG5002	protein histidine kinase activity
SCD_RS03885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SCD_RS03900	COG0482	sulfurtransferase activity
SCD_RS03905	COG0625	glutathione transferase activity
SCD_RS03910	COG1049	propionate catabolic process, 2-methylcitrate cycle
SCD_RS03915	COG0446	pyridine nucleotide-disulphide oxidoreductase
SCD_RS03925	COG0446	pyridine nucleotide-disulphide oxidoreductase
SCD_RS03935	COG2204	response regulator
SCD_RS03945	COG0542	response to heat
SCD_RS03950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SCD_RS03955	COG4783	chaperone-mediated protein folding
SCD_RS03960	COG0315	cyclic pyranopterin monophosphate synthase activity
SCD_RS03965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SCD_RS03970	COG0425	Belongs to the sulfur carrier protein TusA family
SCD_RS03975	COG2210	Belongs to the sulfur carrier protein TusA family
SCD_RS03980	COG0509	glycine decarboxylation via glycine cleavage system
SCD_RS03990	COG0095	Lipoate-protein ligase
SCD_RS04015	COG0525	valine-tRNA ligase activity
SCD_RS04030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SCD_RS04035	COG0795	lipopolysaccharide-transporting ATPase activity
SCD_RS04065	COG0028	Belongs to the TPP enzyme family
SCD_RS04075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SCD_RS04080	COG0688	phosphatidylethanolamine metabolic process
SCD_RS04085	COG1183	phosphatidylcholine synthase activity
SCD_RS04090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SCD_RS04110	COG1959	2 iron, 2 sulfur cluster binding
SCD_RS04110	COG1295	ribonuclease BN
SCD_RS04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SCD_RS04145	COG0521	Mo-molybdopterin cofactor biosynthetic process
SCD_RS04150	COG3028	Belongs to the UPF0307 family
SCD_RS04155	COG0312	modulator of DNA gyrase
SCD_RS04160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SCD_RS04165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SCD_RS04170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SCD_RS04170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SCD_RS04185	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SCD_RS04190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SCD_RS04200	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SCD_RS04205	COG1546	Belongs to the CinA family
SCD_RS04210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SCD_RS04215	COG2137	regulation of response to DNA damage stimulus
SCD_RS04225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SCD_RS04230	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SCD_RS04235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SCD_RS04240	COG0508	dehydrogenase complex catalyzes the overall conversion of
SCD_RS04250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SCD_RS04275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SCD_RS04280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SCD_RS04295	COG1793	dna ligase
SCD_RS04320	COG0642	Histidine kinase
SCD_RS04340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SCD_RS04345	COG0066	3-isopropylmalate dehydratase activity
SCD_RS04350	COG0473	3-isopropylmalate dehydrogenase activity
SCD_RS04370	COG0101	tRNA pseudouridine synthase activity
SCD_RS04375	COG0135	phosphoribosylanthranilate isomerase activity
SCD_RS04380	COG0133	tryptophan synthase activity
SCD_RS04395	COG0159	tryptophan synthase activity
SCD_RS04400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SCD_RS04405	COG0285	dihydrofolate synthase activity
SCD_RS04415	COG1286	toxin biosynthetic process
SCD_RS04435	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SCD_RS04440	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SCD_RS04460	COG3063	Type IV pilus biogenesis stability protein PilW
SCD_RS04465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SCD_RS04470	COG0215	cysteine-tRNA ligase activity
SCD_RS04480	COG0484	heat shock protein binding
SCD_RS04485	COG0443	Heat shock 70 kDa protein
SCD_RS04490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SCD_RS04510	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SCD_RS04515	COG1420	regulation of RNA biosynthetic process
SCD_RS04520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SCD_RS04535	COG0497	DNA recombination
SCD_RS04550	COG0735	belongs to the Fur family
SCD_RS04555	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SCD_RS04560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SCD_RS04565	COG0505	Belongs to the CarA family
SCD_RS04570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SCD_RS04590	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SCD_RS04595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SCD_RS04600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SCD_RS04605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SCD_RS04610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SCD_RS04615	COG0581	inorganic phosphate transmembrane transporter activity
SCD_RS04655	COG0149	triose-phosphate isomerase activity
SCD_RS04670	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SCD_RS04675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SCD_RS04680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SCD_RS04685	COG0649	NAD binding
SCD_RS04690	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SCD_RS04700	COG1034	ATP synthesis coupled electron transport
SCD_RS04705	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SCD_RS04710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SCD_RS04715	COG0839	Belongs to the complex I subunit 6 family
SCD_RS04720	COG0713	ATP synthesis coupled electron transport
SCD_RS04735	COG1007	ATP synthesis coupled electron transport
SCD_RS04750	COG2827	Endonuclease containing a URI domain
SCD_RS04795	COG0326	Molecular chaperone. Has ATPase activity
SCD_RS04810	COG0492	ferredoxin-NADP+ reductase activity
SCD_RS04850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SCD_RS04860	COG0488	(ABC) transporter
SCD_RS04885	COG1704	LemA family
SCD_RS04890	COG1830	Aldolase
SCD_RS04895	COG1127	ABC transporter
SCD_RS04900	COG2081	HI0933 family
SCD_RS04910	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
SCD_RS04915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SCD_RS04935	COG2920	part of a sulfur-relay system
SCD_RS04990	COG2321	neutral zinc metallopeptidase
SCD_RS05060	COG0546	phosphoglycolate phosphatase activity
SCD_RS05065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SCD_RS05070	COG0402	S-adenosylhomocysteine deaminase activity
SCD_RS05085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SCD_RS05095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SCD_RS05100	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SCD_RS05105	COG0287	Prephenate dehydrogenase
SCD_RS05110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SCD_RS05115	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SCD_RS05125	COG0776	regulation of translation
SCD_RS05135	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SCD_RS05140	COG0284	orotidine-5'-phosphate decarboxylase activity
SCD_RS05150	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SCD_RS05155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SCD_RS05200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SCD_RS05215	COG2183	response to ionizing radiation
SCD_RS05245	COG0720	synthase
SCD_RS05385	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SCD_RS05390	COG2716	regulation of RNA biosynthetic process
SCD_RS05400	COG1940	carbohydrate kinase activity
SCD_RS05405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SCD_RS05410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SCD_RS05440	COG1136	(ABC) transporter
SCD_RS05460	COG4771	TonB-dependent receptor
SCD_RS05470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SCD_RS05480	COG3228	Belongs to the MtfA family
SCD_RS05490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SCD_RS05495	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SCD_RS05500	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SCD_RS05505	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SCD_RS05510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SCD_RS05515	COG0072	phenylalanine-tRNA ligase activity
SCD_RS05515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SCD_RS05520	COG0776	regulation of translation
SCD_RS05535	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SCD_RS05540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SCD_RS05565	COG1011	Hydrolase
SCD_RS05575	COG2203	Gaf domain
SCD_RS05575	COG3706	GGDEF domain
SCD_RS05575	COG4251	negative regulation of phosphorylation
SCD_RS05575	COG5001	Diguanylate cyclase
SCD_RS05585	COG0436	Aminotransferase
SCD_RS05610	COG1172	Belongs to the binding-protein-dependent transport system permease family
SCD_RS05630	COG0277	FAD linked oxidase domain protein
SCD_RS05635	COG0277	FAD linked oxidase domain protein
SCD_RS05640	COG0247	lactate metabolic process
SCD_RS05645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SCD_RS05650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SCD_RS05660	COG0542	response to heat
SCD_RS05665	COG0432	Pfam Uncharacterised protein family UPF0047
SCD_RS05690	COG0745	RESPONSE REGULATOR receiver
SCD_RS05700	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
SCD_RS05715	COG2391	methyltransferase activity
SCD_RS05725	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
SCD_RS05740	COG1454	alcohol dehydrogenase
SCD_RS05755	COG0601	transmembrane transport
SCD_RS05760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SCD_RS05765	COG4172	Belongs to the ABC transporter superfamily
SCD_RS05770	COG0741	lytic transglycosylase activity
SCD_RS05770	COG1388	LysM domain
SCD_RS05775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SCD_RS05785	COG0328	RNA-DNA hybrid ribonuclease activity
SCD_RS05815	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SCD_RS05820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SCD_RS05840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SCD_RS05850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SCD_RS05855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SCD_RS05865	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SCD_RS05870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SCD_RS05875	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SCD_RS05880	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SCD_RS05945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SCD_RS05950	COG0668	transmembrane transport
SCD_RS05990	COG0243	molybdopterin cofactor binding
SCD_RS05995	COG0437	4 iron, 4 sulfur cluster binding
SCD_RS06000	COG3302	dmso reductase anchor subunit
SCD_RS06025	COG0300	oxidoreductase activity
SCD_RS06035	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SCD_RS06040	COG2198	Histidine kinase
SCD_RS06040	COG0784	Response regulator, receiver
SCD_RS06040	COG0643	Histidine kinase
SCD_RS06045	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SCD_RS06050	COG0745	RESPONSE REGULATOR receiver
SCD_RS06055	COG0784	Response regulator, receiver
SCD_RS06055	COG0835	chemotaxis
SCD_RS06060	COG0784	Response regulator, receiver
SCD_RS06060	COG0835	chemotaxis
SCD_RS06065	COG3852	Histidine kinase
SCD_RS06075	COG1677	Flagellar hook-basal body complex protein FliE
SCD_RS06080	COG1766	The M ring may be actively involved in energy transduction
SCD_RS06125	COG3190	flagellar
SCD_RS06135	COG1987	bacterial-type flagellum assembly
SCD_RS06160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SCD_RS06165	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
SCD_RS06170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SCD_RS06185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SCD_RS06200	COG0483	inositol monophosphate 1-phosphatase activity
SCD_RS06220	COG1104	cysteine desulfurase activity
SCD_RS06225	COG1104	cysteine desulfurase activity
SCD_RS06230	COG0822	iron-sulfur transferase activity
SCD_RS06235	COG0316	Belongs to the HesB IscA family
SCD_RS06240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SCD_RS06245	COG0443	Heat shock 70 kDa protein
SCD_RS06265	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SCD_RS06285	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SCD_RS06305	COG0314	molybdopterin synthase activity
SCD_RS06310	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SCD_RS06320	COG1763	Mo-molybdopterin cofactor biosynthetic process
SCD_RS06325	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SCD_RS06335	COG2914	Belongs to the UPF0125 (RnfH) family
SCD_RS06355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SCD_RS06355	COG0519	Catalyzes the synthesis of GMP from XMP
SCD_RS06370	COG1376	ErfK ybiS ycfS ynhG family protein
SCD_RS06385	COG0714	Associated with various cellular activities
SCD_RS06390	COG0837	glucose binding
SCD_RS06400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SCD_RS06405	COG1573	uracil-dna glycosylase
SCD_RS06415	COG0322	excinuclease ABC activity
SCD_RS06440	COG2204	response regulator
SCD_RS06510	COG2890	protein-(glutamine-N5) methyltransferase activity
SCD_RS06515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SCD_RS06600	COG3267	Type II secretory pathway component ExeA
SCD_RS06600	COG3409	Peptidoglycan-binding domain 1 protein
SCD_RS06610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SCD_RS06640	COG0438	transferase activity, transferring glycosyl groups
SCD_RS06655	COG0110	maltose O-acetyltransferase activity
SCD_RS06660	COG2226	methyltransferase
SCD_RS06670	COG0297	glycogen (starch) synthase activity
SCD_RS06680	COG0297	glycogen (starch) synthase activity
SCD_RS06690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SCD_RS06700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SCD_RS06715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SCD_RS06745	COG4681	YaeQ
SCD_RS06765	COG1999	signal sequence binding
SCD_RS06780	COG2195	Cleaves the N-terminal amino acid of tripeptides
SCD_RS06800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SCD_RS06840	COG0488	(ABC) transporter
SCD_RS06845	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SCD_RS06855	COG1525	nuclease
SCD_RS06865	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SCD_RS06870	COG0354	folic acid binding
SCD_RS06880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SCD_RS06885	COG1595	DNA-templated transcription, initiation
SCD_RS06895	COG3026	antisigma factor binding
SCD_RS06900	COG3086	response to oxidative stress
SCD_RS06905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SCD_RS06915	COG0481	GTPase activity
SCD_RS06930	COG0571	ribonuclease III activity
SCD_RS06935	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SCD_RS06940	COG0513	Belongs to the DEAD box helicase family
SCD_RS06970	COG1381	Involved in DNA repair and RecF pathway recombination
SCD_RS06975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SCD_RS06980	COG0736	holo-[acyl-carrier-protein] synthase activity
SCD_RS06985	COG1472	Belongs to the glycosyl hydrolase 3 family
SCD_RS06990	COG1067	ATP-dependent peptidase activity
SCD_RS06995	COG5002	protein histidine kinase activity
SCD_RS06995	COG5001	Diguanylate cyclase
SCD_RS07020	COG1309	transcriptional regulator
SCD_RS07040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SCD_RS07050	COG1136	(ABC) transporter
SCD_RS07125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SCD_RS07135	COG1131	(ABC) transporter
SCD_RS07140	COG1131	(ABC) transporter
SCD_RS07145	COG0842	Transport permease protein
SCD_RS07150	COG0842	Transport permease protein
SCD_RS07185	COG1309	transcriptional regulator
SCD_RS07220	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SCD_RS07225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SCD_RS07240	COG0840	transmembrane signaling receptor activity
SCD_RS07245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SCD_RS07245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SCD_RS07250	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SCD_RS07265	COG2201	protein-glutamate methylesterase activity
SCD_RS07270	COG0745	RESPONSE REGULATOR receiver
SCD_RS07280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SCD_RS07280	COG0047	phosphoribosylformylglycinamidine synthase activity
SCD_RS07285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SCD_RS07295	COG2350	Protein conserved in bacteria
SCD_RS07300	COG2917	probably involved in intracellular septation
SCD_RS07305	COG0613	PHP domain protein
SCD_RS07310	COG0009	L-threonylcarbamoyladenylate synthase
SCD_RS07315	COG1994	Peptidase M50
SCD_RS07320	COG0180	Tryptophanyl-tRNA synthetase
SCD_RS07325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SCD_RS07330	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SCD_RS07335	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SCD_RS07340	COG1187	pseudouridine synthase activity
SCD_RS07360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SCD_RS07365	COG1393	Belongs to the ArsC family
SCD_RS07375	COG2079	MmgE PrpD family protein
SCD_RS07390	COG2188	Transcriptional regulator
SCD_RS07395	COG0281	malic enzyme
SCD_RS07405	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SCD_RS07410	COG1053	succinate dehydrogenase
SCD_RS07415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SCD_RS07420	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SCD_RS07425	COG0372	Belongs to the citrate synthase family
SCD_RS07430	COG0567	Dehydrogenase, E1 component
SCD_RS07435	COG0508	dehydrogenase complex catalyzes the overall conversion of
SCD_RS07445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SCD_RS07450	COG0604	alcohol dehydrogenase
SCD_RS07455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SCD_RS07470	COG0513	Belongs to the DEAD box helicase family
SCD_RS07480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SCD_RS07485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SCD_RS07490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SCD_RS07495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SCD_RS07500	COG1127	ABC transporter
SCD_RS07515	COG2197	response regulator
SCD_RS07535	COG1950	PFAM Membrane protein of
SCD_RS07545	COG0084	hydrolase, TatD family'
SCD_RS07560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SCD_RS07565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SCD_RS07575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SCD_RS07585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SCD_RS07600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SCD_RS07605	COG0416	fatty acid biosynthetic process
SCD_RS07610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SCD_RS07615	COG1399	metal-binding, possibly nucleic acid-binding protein
SCD_RS07620	COG0439	Biotin carboxylase
SCD_RS07625	COG0511	ligase activity, forming carbon-carbon bonds
SCD_RS07625	COG5016	pyruvate
SCD_RS07630	COG0424	maF-like protein
SCD_RS07635	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SCD_RS07645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SCD_RS07645	COG0616	signal peptide processing
SCD_RS07650	COG0546	phosphoglycolate phosphatase activity
SCD_RS07660	COG1530	ribonuclease E activity
SCD_RS07665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SCD_RS07675	COG0556	nucleotide-excision repair
SCD_RS07680	COG0436	Aminotransferase
SCD_RS07695	COG1580	Controls the rotational direction of flagella during chemotaxis
SCD_RS07705	COG2824	Alkylphosphonate utilization operon protein PhnA
SCD_RS07725	COG0653	protein targeting
SCD_RS07745	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SCD_RS07760	COG5002	protein histidine kinase activity
SCD_RS07760	COG5001	Diguanylate cyclase
SCD_RS07770	COG1217	gtp-binding protein TYPA
SCD_RS07790	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SCD_RS07795	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SCD_RS07800	COG4181	ATPase activity
SCD_RS07815	COG0745	RESPONSE REGULATOR receiver
SCD_RS07825	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SCD_RS07850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SCD_RS07855	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SCD_RS07865	COG0583	DNA-binding transcription factor activity
SCD_RS07870	COG0477	Major facilitator Superfamily
SCD_RS07880	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SCD_RS07885	COG1704	LemA family
SCD_RS07890	COG1573	uracil-dna glycosylase
SCD_RS07895	COG0456	acetyltransferase
SCD_RS07900	COG1214	PFAM Peptidase M22, glycoprotease
SCD_RS07910	COG1199	ATP-dependent helicase activity
SCD_RS07920	COG3259	Nickel-dependent hydrogenase
SCD_RS07925	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
SCD_RS07930	COG3383	formate dehydrogenase (NAD+) activity
SCD_RS07935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SCD_RS07940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SCD_RS07950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SCD_RS07965	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SCD_RS07970	COG0148	phosphopyruvate hydratase activity
SCD_RS07975	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SCD_RS07980	COG0504	CTP synthase activity
SCD_RS07985	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SCD_RS07990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SCD_RS08010	COG1360	Flagellar Motor Protein
SCD_RS08025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SCD_RS08030	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SCD_RS08035	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SCD_RS08040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SCD_RS08045	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SCD_RS08050	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
SCD_RS08065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SCD_RS08070	COG0575	Belongs to the CDS family
SCD_RS08075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SCD_RS08080	COG0233	cytoplasmic translational termination
SCD_RS08085	COG0528	UMP kinase activity
SCD_RS08090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SCD_RS08095	COG0052	Belongs to the universal ribosomal protein uS2 family
SCD_RS08105	COG0024	Methionine aminopeptidase
SCD_RS08110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SCD_RS08115	COG0076	glutamate decarboxylase activity
SCD_RS08130	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SCD_RS08155	COG1516	flagellar protein fliS
SCD_RS08185	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SCD_RS08205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SCD_RS08220	COG0242	peptide deformylase activity
SCD_RS08235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SCD_RS08240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SCD_RS08245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SCD_RS08270	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SCD_RS08275	COG1070	Carbohydrate kinase
SCD_RS08300	COG0436	Aminotransferase
SCD_RS08305	COG2171	N-acyltransferase activity
SCD_RS08310	COG0367	asparagine synthase
SCD_RS08320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SCD_RS08325	COG2951	lytic endotransglycosylase activity
SCD_RS08335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SCD_RS08355	COG1566	PFAM secretion protein HlyD family protein
SCD_RS08360	COG0577	efflux transmembrane transporter activity
SCD_RS08360	COG1136	(ABC) transporter
SCD_RS08365	COG0577	efflux transmembrane transporter activity
SCD_RS08365	COG1136	(ABC) transporter
SCD_RS08375	COG0560	Phosphoserine phosphatase
SCD_RS08400	COG1705	Flagellar rod assembly protein muramidase FlgJ
SCD_RS08400	COG3951	Flagellar rod assembly protein muramidase FlgJ
SCD_RS08405	COG1706	bacterial-type flagellum-dependent cell motility
SCD_RS08410	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SCD_RS08420	COG4787	bacterial-type flagellum-dependent cell motility
SCD_RS08430	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SCD_RS08435	COG1558	bacterial-type flagellum-dependent cell motility
SCD_RS08455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SCD_RS08460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SCD_RS08465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SCD_RS08475	COG1185	polyribonucleotide nucleotidyltransferase activity
SCD_RS08480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SCD_RS08485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SCD_RS08490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SCD_RS08495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SCD_RS08500	COG0195	Participates in both transcription termination and antitermination
SCD_RS08500	COG2251	uridine kinase activity
SCD_RS08505	COG0779	Required for maturation of 30S ribosomal subunits
SCD_RS08540	COG2046	Belongs to the sulfate adenylyltransferase family
SCD_RS08570	COG0450	alkyl hydroperoxide reductase
SCD_RS08590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SCD_RS08610	COG0484	heat shock protein binding
SCD_RS08625	COG1674	ftsk spoiiie
SCD_RS08630	COG0492	ferredoxin-NADP+ reductase activity
SCD_RS08640	COG0463	Glycosyl transferase, family 2
SCD_RS08655	COG0671	phosphoesterase, PA-phosphatase related
SCD_RS08660	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SCD_RS08665	COG2076	Multidrug Resistance protein
SCD_RS08670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SCD_RS08680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SCD_RS08680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SCD_RS08690	COG0726	polysaccharide deacetylase
SCD_RS08695	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SCD_RS08700	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SCD_RS08705	COG1355	regulation of microtubule-based process
SCD_RS08730	COG0791	NLP P60 protein
SCD_RS08735	COG1752	Esterase of the alpha-beta hydrolase superfamily
SCD_RS08770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SCD_RS08775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SCD_RS08780	COG0740	serine-type endopeptidase activity
SCD_RS08785	COG0544	peptidyl-prolyl cis-trans isomerase activity
SCD_RS08800	COG1562	ergosterol biosynthetic process
SCD_RS08805	COG1233	COG1233 Phytoene dehydrogenase and related
SCD_RS08810	COG1028	Short-chain dehydrogenase reductase Sdr
SCD_RS08815	COG1716	ATPase activity
SCD_RS08820	COG0631	protein serine/threonine phosphatase activity
SCD_RS08825	COG0515	serine threonine protein kinase
SCD_RS08845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SCD_RS08850	COG0305	Participates in initiation and elongation during chromosome replication
SCD_RS08860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SCD_RS08870	COG0360	Binds together with S18 to 16S ribosomal RNA
SCD_RS08875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SCD_RS08880	COG0557	exoribonuclease II activity
SCD_RS08890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SCD_RS08895	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SCD_RS08905	COG0330	HflC and HflK could
SCD_RS08910	COG0330	HflC and HflK could
SCD_RS08915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SCD_RS08920	COG1923	regulation of RNA biosynthetic process
SCD_RS08935	COG1160	GTP binding
SCD_RS08945	COG2976	Protein conserved in bacteria
SCD_RS08950	COG0124	histidyl-tRNA synthetase
SCD_RS08955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SCD_RS08960	COG1426	Protein conserved in bacteria
SCD_RS08970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SCD_RS08975	COG0105	UTP biosynthetic process
SCD_RS09010	COG0037	tRNA processing
SCD_RS09015	COG0825	malonyl-CoA metabolic process
SCD_RS09020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SCD_RS09045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SCD_RS09110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SCD_RS09125	COG0564	pseudouridine synthase activity
SCD_RS09135	COG0347	Belongs to the P(II) protein family
SCD_RS09145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SCD_RS09150	COG0045	succinate-CoA ligase (ADP-forming) activity
SCD_RS09155	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SCD_RS09195	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SCD_RS09200	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SCD_RS09210	COG0784	Response regulator, receiver
SCD_RS09220	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SCD_RS09230	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SCD_RS09235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SCD_RS09245	COG0717	Belongs to the dCTP deaminase family
SCD_RS09255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SCD_RS09255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SCD_RS09265	COG1254	Belongs to the acylphosphatase family
SCD_RS09280	COG0826	peptidase U32
SCD_RS09290	COG0004	ammonium transporteR
SCD_RS09305	COG2048	Heterodisulfide reductase, subunit B
SCD_RS09310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SCD_RS09320	COG1233	COG1233 Phytoene dehydrogenase and related
SCD_RS09330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SCD_RS09335	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SCD_RS09340	COG0205	6-phosphofructokinase activity
SCD_RS09350	COG0563	adenylate kinase activity
SCD_RS09355	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SCD_RS09360	COG2835	tetraacyldisaccharide 4'-kinase activity
SCD_RS09365	COG1663	tetraacyldisaccharide 4'-kinase activity
SCD_RS09370	COG0848	biopolymer transport protein
SCD_RS09375	COG0811	peptide transport
SCD_RS09380	COG1570	exodeoxyribonuclease VII activity
SCD_RS09395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SCD_RS09400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SCD_RS09410	COG0438	transferase activity, transferring glycosyl groups
SCD_RS09420	COG0860	N-Acetylmuramoyl-L-alanine amidase
SCD_RS09425	COG0802	atpase or kinase
SCD_RS09430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SCD_RS09440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SCD_RS09450	COG2871	sodium ion transport
SCD_RS09460	COG5012	cobalamin binding
SCD_RS09510	COG1047	Peptidyl-prolyl cis-trans
SCD_RS09515	COG1449	Belongs to the glycosyl hydrolase 57 family
SCD_RS09525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SCD_RS09530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SCD_RS09535	COG0166	Belongs to the GPI family
SCD_RS09545	COG0363	glucosamine-6-phosphate deaminase activity
SCD_RS09555	COG1595	DNA-templated transcription, initiation
SCD_RS09570	COG0297	glycogen (starch) synthase activity
SCD_RS09580	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SCD_RS09585	COG0501	Belongs to the peptidase M48B family
SCD_RS09595	COG2154	pterin-4-alpha-carbinolamine dehydratase
SCD_RS09600	COG1162	GTPase activity
SCD_RS09605	COG3012	SEC-C Motif Domain Protein
SCD_RS09615	COG0123	including yeast histone deacetylase and acetoin utilization protein
SCD_RS09640	COG0312	modulator of DNA gyrase
SCD_RS09645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SCD_RS09655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SCD_RS09685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SCD_RS09690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SCD_RS09705	COG0859	PFAM glycosyl transferase family 9
SCD_RS09720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SCD_RS09740	COG4657	Part of a membrane complex involved in electron transport
SCD_RS09745	COG2878	Part of a membrane complex involved in electron transport
SCD_RS09750	COG4656	Part of a membrane complex involved in electron transport
SCD_RS09780	COG0167	dihydroorotate dehydrogenase activity
SCD_RS09785	COG0686	Belongs to the AlaDH PNT family
SCD_RS09790	COG4657	Part of a membrane complex involved in electron transport
SCD_RS09795	COG2878	Part of a membrane complex involved in electron transport
SCD_RS09800	COG4656	Part of a membrane complex involved in electron transport
SCD_RS09815	COG4660	Part of a membrane complex involved in electron transport
SCD_RS09830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SCD_RS09850	COG1944	ATP diphosphatase activity
SCD_RS09860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SCD_RS09875	COG0753	catalase activity
SCD_RS09880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SCD_RS09885	COG0861	Integral membrane protein TerC family
SCD_RS09895	COG2111	Na H antiporter
SCD_RS09895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SCD_RS09900	COG1006	Multisubunit Na H antiporter MnhC subunit
SCD_RS09905	COG0651	ATP synthesis coupled electron transport
SCD_RS09910	COG1863	multisubunit Na H antiporter MnhE subunit
SCD_RS09915	COG2212	antiporter activity
SCD_RS09920	COG1320	monovalent cation:proton antiporter activity
SCD_RS09925	COG1283	sodium-dependent phosphate transmembrane transporter activity
SCD_RS09935	COG1275	C4-dicarboxylate transporter malic acid transport protein
SCD_RS09940	COG0589	response to stress
SCD_RS09985	COG0589	response to stress
SCD_RS10000	COG0651	ATP synthesis coupled electron transport
SCD_RS10005	COG0650	Formate hydrogenlyase subunit 4
SCD_RS10015	COG0651	ATP synthesis coupled electron transport
SCD_RS10020	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SCD_RS10020	COG3261	NADH dehydrogenase
SCD_RS10025	COG3260	NADH ubiquinone oxidoreductase 20
SCD_RS10040	COG0583	DNA-binding transcription factor activity
SCD_RS10045	COG1850	ribulose-bisphosphate carboxylase activity
SCD_RS10050	COG4451	ribulose bisphosphate carboxylase, small
SCD_RS10060	COG4548	von Willebrand factor, type A
SCD_RS10085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SCD_RS10090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SCD_RS10095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SCD_RS10100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SCD_RS10105	COG0288	reversible hydration of carbon dioxide
SCD_RS10110	COG2096	Adenosyltransferase
SCD_RS10115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SCD_RS10145	COG0840	transmembrane signaling receptor activity
SCD_RS10160	COG0642	Histidine kinase
SCD_RS10170	COG1187	pseudouridine synthase activity
SCD_RS10200	COG2920	part of a sulfur-relay system
SCD_RS10225	COG2732	(Barnase) inhibitor
SCD_RS10230	COG4290	ribonuclease
SCD_RS10235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SCD_RS10245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SCD_RS10250	COG1720	tRNA m6t6A37 methyltransferase activity
SCD_RS10260	COG2221	Nitrite and sulphite reductase 4Fe-4S
SCD_RS10265	COG5002	protein histidine kinase activity
SCD_RS10265	COG2205	protein histidine kinase activity
SCD_RS10265	COG0784	Response regulator, receiver
SCD_RS10325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SCD_RS10330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SCD_RS10330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SCD_RS10355	COG0788	formyltetrahydrofolate deformylase activity
SCD_RS10375	COG3023	N-Acetylmuramoyl-L-alanine amidase
SCD_RS10390	COG0058	SHG alpha-glucan phosphorylase activity
SCD_RS10415	COG0142	geranyltranstransferase activity
SCD_RS10420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SCD_RS10425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SCD_RS10430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SCD_RS10435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SCD_RS10455	COG0494	nUDIX hydrolase
SCD_RS10460	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SCD_RS10475	COG4575	ribosome binding
SCD_RS10480	COG0442	prolyl-tRNA aminoacylation
SCD_RS10485	COG0741	lytic transglycosylase activity
SCD_RS10495	COG0735	belongs to the Fur family
SCD_RS10535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SCD_RS10540	COG1047	Peptidyl-prolyl cis-trans
SCD_RS10545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SCD_RS10550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SCD_RS10555	COG0196	riboflavin kinase activity
SCD_RS10560	COG0728	peptidoglycan biosynthetic process
SCD_RS10565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SCD_RS10580	COG1331	Highly conserved protein containing a thioredoxin domain
SCD_RS10590	COG0501	Belongs to the peptidase M48B family
SCD_RS10605	COG0583	DNA-binding transcription factor activity
SCD_RS10610	COG1230	cation diffusion facilitator family transporter
SCD_RS10635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SCD_RS10655	COG2226	methyltransferase
SCD_RS10670	COG0798	PFAM Bile acid sodium symporter
SCD_RS10675	COG0640	Transcriptional regulator
SCD_RS10685	COG3038	cytochrome b561
SCD_RS10720	COG0583	DNA-binding transcription factor activity
SCD_RS10755	COG1881	PFAM PEBP family protein
SCD_RS10760	COG0023	Translation Initiation Factor
SCD_RS10770	COG5265	(ABC) transporter
SCD_RS10785	COG1278	Cold shock
SCD_RS10800	COG0268	Binds directly to 16S ribosomal RNA
SCD_RS10805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SCD_RS10810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SCD_RS10815	COG0137	argininosuccinate synthase activity
SCD_RS10820	COG3123	guanosine phosphorylase activity
SCD_RS10825	COG1666	GTP binding
SCD_RS10835	COG0519	Catalyzes the synthesis of GMP from XMP
SCD_RS10835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SCD_RS10850	COG1469	GTP cyclohydrolase I activity
SCD_RS10855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SCD_RS10860	COG0142	geranyltranstransferase activity
SCD_RS10865	COG1722	exodeoxyribonuclease VII activity
SCD_RS10885	COG3409	Peptidoglycan-binding domain 1 protein
SCD_RS10885	COG3267	Type II secretory pathway component ExeA
SCD_RS10895	COG1515	deoxyribonuclease V activity
SCD_RS10910	COG0586	Pfam SNARE associated Golgi protein
SCD_RS10915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SCD_RS10920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SCD_RS10925	COG1862	Preprotein translocase
SCD_RS10930	COG0343	queuine tRNA-ribosyltransferase activity
SCD_RS10935	COG0330	HflC and HflK could
SCD_RS10945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SCD_RS10955	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SCD_RS10960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SCD_RS10970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SCD_RS10980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SCD_RS10985	COG0617	tRNA 3'-terminal CCA addition
SCD_RS10995	COG1120	ATPase activity
SCD_RS11000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SCD_RS11020	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SCD_RS11020	COG1013	pyruvate-flavodoxin oxidoreductase activity
SCD_RS11020	COG0674	pyruvate-flavodoxin oxidoreductase activity
SCD_RS11020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SCD_RS11025	COG1643	Atp-dependent helicase
SCD_RS11035	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SCD_RS11040	COG0412	Dienelactone hydrolase
SCD_RS11055	COG1671	Belongs to the UPF0178 family
SCD_RS11060	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SCD_RS11080	COG2770	Histidine kinase
SCD_RS11080	COG3437	response regulator, receiver
SCD_RS11130	COG2132	Multicopper oxidase
SCD_RS11145	COG5002	protein histidine kinase activity
SCD_RS11155	COG2226	methyltransferase
SCD_RS11175	COG3707	response regulator
SCD_RS11180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SCD_RS11185	COG1017	nitric oxide dioxygenase activity
SCD_RS11185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SCD_RS11195	COG1116	anion transmembrane transporter activity
SCD_RS11200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SCD_RS11210	COG0243	molybdopterin cofactor binding
SCD_RS11215	COG0437	4 iron, 4 sulfur cluster binding
SCD_RS11235	COG2223	nitrite transmembrane transporter activity
SCD_RS11255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SCD_RS11260	COG1187	pseudouridine synthase activity
SCD_RS11290	COG5002	protein histidine kinase activity
SCD_RS11315	COG1639	'signal transduction protein
SCD_RS11320	COG4191	Histidine kinase
SCD_RS11325	COG4566	intracellular signal transduction
SCD_RS11350	COG3437	response regulator, receiver
SCD_RS11355	COG2204	response regulator
SCD_RS11360	COG1100	Small GTP-binding protein
SCD_RS11365	COG4191	Histidine kinase
SCD_RS11370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SCD_RS11435	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SCD_RS11445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SCD_RS11450	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SCD_RS11455	COG3300	MHYT domain
SCD_RS11455	COG5001	Diguanylate cyclase
SCD_RS11465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SCD_RS11495	COG0840	transmembrane signaling receptor activity
SCD_RS11500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SCD_RS11505	COG1741	Belongs to the pirin family
SCD_RS11510	COG1902	pentaerythritol trinitrate reductase activity
SCD_RS11540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SCD_RS11545	COG1215	transferase activity, transferring glycosyl groups
SCD_RS11570	COG1132	(ABC) transporter
SCD_RS11625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SCD_RS11635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SCD_RS11645	COG1278	Cold shock
SCD_RS11650	COG0628	permease
SCD_RS11655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SCD_RS11660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SCD_RS11675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SCD_RS11675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SCD_RS11700	COG2974	May be involved in recombination
SCD_RS11705	COG2833	Protein of unknown function (DUF455)
SCD_RS11710	COG1451	nucleotide metabolic process
SCD_RS11755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SCD_RS11760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SCD_RS11770	COG3025	triphosphatase activity
SCD_RS11790	COG0631	protein serine/threonine phosphatase activity
SCD_RS11795	COG1716	ATPase activity
SCD_RS11815	COG0463	Glycosyl transferase, family 2
SCD_RS11820	COG0438	transferase activity, transferring glycosyl groups
SCD_RS11840	COG1215	transferase activity, transferring glycosyl groups
SCD_RS11890	COG0577	efflux transmembrane transporter activity
SCD_RS11890	COG1136	(ABC) transporter
SCD_RS11895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SCD_RS11900	COG0737	Belongs to the 5'-nucleotidase family
SCD_RS11905	COG3258	Cytochrome c
SCD_RS11930	COG3001	Fructosamine kinase
SCD_RS11940	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SCD_RS11965	COG2308	Evidence 4 Homologs of previously reported genes of
SCD_RS11990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SCD_RS11995	COG0366	Alpha amylase catalytic
SCD_RS12000	COG0366	Alpha amylase catalytic
SCD_RS12010	COG0366	Alpha amylase catalytic
SCD_RS12015	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SCD_RS12025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SCD_RS12030	COG1640	4-alpha-glucanotransferase
SCD_RS12035	COG1295	ribonuclease BN
SCD_RS12040	COG3706	GGDEF domain
SCD_RS12050	COG3008	intermembrane lipid transfer
SCD_RS12050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SCD_RS12055	COG2995	paraquat-inducible protein a
SCD_RS12060	COG2995	paraquat-inducible protein a
SCD_RS12085	COG1970	mechanosensitive ion channel activity
SCD_RS12110	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SCD_RS12115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SCD_RS12125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SCD_RS12140	COG4974	Belongs to the 'phage' integrase family
SCD_RS12145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SCD_RS12150	COG0335	large ribosomal subunit rRNA binding
SCD_RS12155	COG0336	Belongs to the RNA methyltransferase TrmD family
SCD_RS12160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SCD_RS12165	COG0228	four-way junction DNA binding
SCD_RS12170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SCD_RS12175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SCD_RS12180	COG4536	flavin adenine dinucleotide binding
SCD_RS12195	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SCD_RS12200	COG0237	dephospho-CoA kinase activity
SCD_RS12205	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
SCD_RS12215	COG0494	nUDIX hydrolase
SCD_RS12230	COG0653	protein targeting
SCD_RS12235	COG0739	heme binding
SCD_RS12250	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SCD_RS12265	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SCD_RS12270	COG1181	Belongs to the D-alanine--D-alanine ligase family
SCD_RS12275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SCD_RS12280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SCD_RS12285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SCD_RS12290	COG0772	Belongs to the SEDS family
SCD_RS12295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SCD_RS12300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SCD_RS12305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SCD_RS12310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SCD_RS12320	COG3116	cell division
SCD_RS12325	COG0275	rRNA processing
SCD_RS12330	COG2001	Belongs to the MraZ family
SCD_RS12340	COG0418	dihydroorotase activity
SCD_RS12360	COG3107	peptidoglycan biosynthetic process
SCD_RS12365	COG0792	nuclease activity
SCD_RS12370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SCD_RS12380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SCD_RS12385	COG0277	FAD linked oxidase domain protein
SCD_RS12395	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SCD_RS12400	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SCD_RS12400	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SCD_RS12430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SCD_RS12440	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SCD_RS12445	COG0316	Belongs to the HesB IscA family
SCD_RS12460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SCD_RS12465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SCD_RS12470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SCD_RS12480	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SCD_RS12490	COG4115	mRNA cleavage
SCD_RS12495	COG2161	toxin-antitoxin pair type II binding
SCD_RS12505	COG0134	indole-3-glycerol-phosphate synthase activity
SCD_RS12510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SCD_RS12515	COG2852	Protein conserved in bacteria
SCD_RS12530	COG0546	phosphoglycolate phosphatase activity
SCD_RS12535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SCD_RS12540	COG2967	ApaG domain
SCD_RS12545	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SCD_RS12615	COG2204	response regulator
SCD_RS12630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SCD_RS12635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SCD_RS12640	COG0006	proline dipeptidase activity
SCD_RS12645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SCD_RS12655	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SCD_RS12660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SCD_RS12665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SCD_RS12670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SCD_RS12695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SCD_RS12700	COG0751	glycine-tRNA ligase activity
SCD_RS12705	COG0752	glycyl-tRNA synthetase alpha subunit
SCD_RS12715	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SCD_RS12740	COG2808	Putative FMN-binding domain
SCD_RS12765	COG2885	chlorophyll binding
SCD_RS12770	COG0659	secondary active sulfate transmembrane transporter activity
SCD_RS12780	COG0642	Histidine kinase
SCD_RS12800	COG4535	Mg2 and Co2 transporter CorC
SCD_RS12805	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SCD_RS12810	COG1702	phosphate starvation-inducible protein PhoH
SCD_RS12815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SCD_RS12855	COG3220	belongs to the UPF0276 family
SCD_RS12865	COG2259	Doxx family
SCD_RS12880	COG3530	Putative quorum-sensing-regulated virulence factor
SCD_RS12885	COG0659	secondary active sulfate transmembrane transporter activity
SCD_RS12905	COG1301	dicarboxylic acid transport
SCD_RS12925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SCD_RS12930	COG0785	Cytochrome C biogenesis protein
SCD_RS12930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SCD_RS12935	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SCD_RS12945	COG0012	GTP binding
SCD_RS12950	COG1187	pseudouridine synthase activity
SCD_RS12955	COG0193	aminoacyl-tRNA hydrolase activity
SCD_RS12960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SCD_RS12965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SCD_RS12975	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SCD_RS12980	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
SCD_RS12990	COG1131	(ABC) transporter
SCD_RS13010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SCD_RS13025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SCD_RS13030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SCD_RS13035	COG0742	ribosomal rna small subunit methyltransferase
SCD_RS13040	COG0612	Peptidase, M16
SCD_RS13045	COG0612	Peptidase, M16
SCD_RS13055	COG2884	Cell division ATP-binding protein ftsE
SCD_RS13060	COG2177	Part of the ABC transporter FtsEX involved in
SCD_RS13065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SCD_RS13075	COG2217	Heavy metal translocating P-type atpase
SCD_RS13085	COG0348	domain, Protein
SCD_RS13100	COG3278	Belongs to the heme-copper respiratory oxidase family
SCD_RS13105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SCD_RS13110	COG1999	signal sequence binding
SCD_RS13120	COG1612	heme a metabolic process
SCD_RS13125	COG0109	protoheme IX farnesyltransferase activity
SCD_RS13155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SCD_RS13165	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SCD_RS13170	COG2226	methyltransferase
SCD_RS13175	COG2267	carboxylic ester hydrolase activity
SCD_RS13180	COG0156	8-amino-7-oxononanoate synthase activity
SCD_RS13185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SCD_RS13195	COG1040	competence protein
SCD_RS13205	COG3409	Peptidoglycan-binding domain 1 protein
SCD_RS13205	COG3267	Type II secretory pathway component ExeA
SCD_RS13265	COG2165	general secretion pathway protein
SCD_RS13285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SCD_RS13290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SCD_RS13295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SCD_RS13305	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SCD_RS13310	COG3118	belongs to the thioredoxin family
SCD_RS13320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SCD_RS13335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SCD_RS13345	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SCD_RS13355	COG0793	Belongs to the peptidase S41A family
SCD_RS13370	COG1309	transcriptional regulator
SCD_RS13375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SCD_RS13385	COG1797	cobyrinic acid a,c-diamide synthase activity
SCD_RS13420	COG2920	part of a sulfur-relay system
SCD_RS13425	COG2168	tRNA wobble position uridine thiolation
SCD_RS13430	COG2923	Belongs to the DsrF TusC family
SCD_RS13435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
SCD_RS13440	COG2221	Nitrite and sulphite reductase 4Fe-4S
SCD_RS13445	COG2221	Nitrite and sulphite reductase 4Fe-4S
SCD_RS13460	COG2920	part of a sulfur-relay system
SCD_RS13475	COG0574	Belongs to the PEP-utilizing enzyme family
SCD_RS13475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SCD_RS13500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SCD_RS13505	COG3132	Protein of unknown function, DUF480
SCD_RS13510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SCD_RS13520	COG3088	subunit of a heme lyase
SCD_RS13525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SCD_RS13535	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SCD_RS13540	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SCD_RS13555	COG4133	protoheme IX ABC transporter activity
SCD_RS13575	COG4654	Cytochrome c, class I
SCD_RS13590	COG2204	response regulator
SCD_RS13595	COG4191	Histidine kinase
SCD_RS13630	COG0475	glutathione-regulated potassium exporter activity
SCD_RS13635	COG1028	Short-chain dehydrogenase reductase Sdr
SCD_RS13650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SCD_RS13660	COG0726	polysaccharide deacetylase
SCD_RS13710	COG0210	DNA helicase
SCD_RS13735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SCD_RS13745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SCD_RS13750	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SCD_RS13755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SCD_RS13760	COG0509	glycine decarboxylation via glycine cleavage system
SCD_RS13765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SCD_RS13775	COG2264	protein methyltransferase activity
SCD_RS13780	COG0439	Biotin carboxylase
SCD_RS13785	COG0511	ligase activity, forming carbon-carbon bonds
SCD_RS13790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SCD_RS13795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SCD_RS13800	COG4232	protein-disulfide reductase activity
SCD_RS13805	COG1324	tolerance protein
SCD_RS13840	COG1587	Uroporphyrinogen-III synthase
SCD_RS13845	COG0181	hydroxymethylbilane synthase activity
SCD_RS13860	COG3275	phosphorelay sensor kinase activity
SCD_RS13865	COG0165	Argininosuccinate lyase
SCD_RS13875	COG1785	Belongs to the alkaline phosphatase family
SCD_RS13890	COG1459	type II secretion system
SCD_RS13895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SCD_RS13935	COG1611	Belongs to the LOG family
SCD_RS13950	COG0739	heme binding
SCD_RS13950	COG0741	lytic transglycosylase activity
SCD_RS13950	COG1196	nuclear chromosome segregation
SCD_RS13985	COG0811	peptide transport
SCD_RS14035	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SCD_RS14040	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SCD_RS14045	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SCD_RS14045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SCD_RS14050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SCD_RS14060	COG0483	inositol monophosphate 1-phosphatase activity
SCD_RS14065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SCD_RS14070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SCD_RS14075	COG0126	phosphoglycerate kinase activity
SCD_RS14085	COG0191	fructose-bisphosphate aldolase activity
SCD_RS14095	COG1850	ribulose-bisphosphate carboxylase activity
SCD_RS14110	COG0205	6-phosphofructokinase activity
SCD_RS14120	COG0730	response to heat
SCD_RS14130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SCD_RS14145	COG4771	TonB-dependent receptor
SCD_RS14150	COG0859	PFAM glycosyl transferase family 9
SCD_RS14155	COG0438	transferase activity, transferring glycosyl groups
SCD_RS14160	COG1132	(ABC) transporter
SCD_RS14165	COG0438	transferase activity, transferring glycosyl groups
SCD_RS14180	COG0438	transferase activity, transferring glycosyl groups
SCD_RS14215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SCD_RS14240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SCD_RS14270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SCD_RS14290	COG0463	Glycosyl transferase, family 2
SCD_RS14295	COG2226	methyltransferase
SCD_RS14300	COG0463	Glycosyl transferase, family 2
SCD_RS14320	COG0154	amidase activity
SCD_RS14340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SCD_RS14350	COG2089	acid synthase
SCD_RS14365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SCD_RS14375	COG1083	cytidylyl-transferase
SCD_RS14380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SCD_RS14385	COG1086	Polysaccharide biosynthesis protein
SCD_RS14390	COG1132	(ABC) transporter
SCD_RS14430	COG0859	PFAM glycosyl transferase family 9
SCD_RS14435	COG1519	Transferase
SCD_RS14440	COG1538	Outer membrane efflux protein
SCD_RS14445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SCD_RS14450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SCD_RS14455	COG1968	undecaprenyl-diphosphatase activity
SCD_RS14460	COG0643	Histidine kinase
SCD_RS14460	COG2198	Histidine kinase
SCD_RS14485	COG0351	phosphomethylpyrimidine kinase
SCD_RS14490	COG0352	thiamine-phosphate diphosphorylase activity
SCD_RS14495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SCD_RS14530	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SCD_RS14540	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SCD_RS14580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SCD_RS14585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SCD_RS14590	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SCD_RS14605	COG0489	protein tyrosine kinase activity
SCD_RS14615	COG3267	Type II secretory pathway component ExeA
SCD_RS14615	COG3409	Peptidoglycan-binding domain 1 protein
SCD_RS14645	COG0297	glycogen (starch) synthase activity
SCD_RS14650	COG0367	asparagine synthase
SCD_RS14660	COG0438	transferase activity, transferring glycosyl groups
SCD_RS14675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SCD_RS14695	COG1216	Glycosyl transferase, family 2
SCD_RS14695	COG1442	glycosyl transferase family 8
SCD_RS14700	COG0438	transferase activity, transferring glycosyl groups
SCD_RS14715	COG1216	Glycosyl transferase, family 2
SCD_RS14725	COG3119	arylsulfatase activity
SCD_RS14730	COG1215	transferase activity, transferring glycosyl groups
SCD_RS14745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SCD_RS14790	COG0367	asparagine synthase
SCD_RS14795	COG2204	response regulator
SCD_RS14805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SCD_RS14845	COG0577	efflux transmembrane transporter activity
SCD_RS14850	COG1136	(ABC) transporter
SCD_RS14850	COG0577	efflux transmembrane transporter activity
SCD_RS14860	COG1136	(ABC) transporter
SCD_RS14885	COG0070	glutamate synthase
SCD_RS14885	COG0069	glutamate synthase activity
SCD_RS14885	COG0067	glutamate synthase
SCD_RS14895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SCD_RS14900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SCD_RS14905	COG0018	arginyl-trna synthetase
SCD_RS14915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SCD_RS14920	COG2197	response regulator
SCD_RS14930	COG1192	Involved in chromosome partitioning
SCD_RS14940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SCD_RS14945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SCD_RS14950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SCD_RS14955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SCD_RS14960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SCD_RS14965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SCD_RS14970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SCD_RS14980	COG0356	it plays a direct role in the translocation of protons across the membrane
SCD_RS14995	COG1192	Involved in chromosome partitioning
SCD_RS15000	COG0357	Ribosomal RNA small subunit methyltransferase G
SCD_RS15005	COG0445	tRNA wobble uridine modification
SCD_RS15010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SCD_RS15015	COG0706	membrane insertase activity
SCD_RS15020	COG0594	ribonuclease P activity
SCD_RS15530	COG1169	isochorismate synthase
SCD_RS15560	COG5001	Diguanylate cyclase
SCD_RS15560	COG5002	protein histidine kinase activity
SCD_RS15575	COG5002	protein histidine kinase activity
SCD_RS15575	COG5001	Diguanylate cyclase
SCD_RS15580	COG5001	Diguanylate cyclase
SCD_RS15580	COG5002	protein histidine kinase activity
SCD_RS15610	COG3706	GGDEF domain
SCD_RS15615	COG5001	Diguanylate cyclase
SCD_RS15615	COG4251	negative regulation of phosphorylation
SCD_RS15615	COG3706	GGDEF domain
SCD_RS15615	COG2203	Gaf domain
SCD_RS15625	COG4251	negative regulation of phosphorylation
SCD_RS15660	COG2199	diguanylate cyclase activity
SCD_RS15660	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SCD_RS15665	COG5002	protein histidine kinase activity
SCD_RS15670	COG1334	flagellar protein FlaG
SCD_RS15705	COG3706	GGDEF domain
SCD_RS15710	COG3437	response regulator, receiver
SCD_RS15710	COG0784	Response regulator, receiver
SCD_RS15725	COG4251	negative regulation of phosphorylation
SCD_RS15730	COG5001	Diguanylate cyclase
SCD_RS15730	COG3300	MHYT domain
SCD_RS15735	COG2199	diguanylate cyclase activity
SCD_RS15735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SCD_RS15785	COG5001	Diguanylate cyclase
SCD_RS15815	COG3300	MHYT domain
SCD_RS15815	COG5001	Diguanylate cyclase
SCD_RS15865	COG3437	response regulator, receiver
SCD_RS15940	COG1215	transferase activity, transferring glycosyl groups
SCD_RS15945	COG0438	transferase activity, transferring glycosyl groups