locus-tag	class	description
SVA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SVA_RS00015	COG0187	DNA topoisomerase II activity
SVA_RS00020	COG2967	ApaG domain
SVA_RS00025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SVA_RS00030	COG0596	Alpha beta hydrolase
SVA_RS00035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SVA_RS00040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SVA_RS00045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SVA_RS00050	COG0037	tRNA processing
SVA_RS00055	COG1560	Kdo2-lipid A biosynthetic process
SVA_RS00060	COG1560	Kdo2-lipid A biosynthetic process
SVA_RS00070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SVA_RS00075	COG0569	domain protein
SVA_RS00080	COG2204	response regulator
SVA_RS00085	COG5000	phosphorelay sensor kinase activity
SVA_RS00095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SVA_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SVA_RS00100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SVA_RS00105	COG0242	peptide deformylase activity
SVA_RS00115	COG0758	DNA mediated transformation
SVA_RS00120	COG2922	Belongs to the Smg family
SVA_RS00145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SVA_RS00155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SVA_RS00165	COG0508	dehydrogenase complex catalyzes the overall conversion of
SVA_RS00180	COG3245	cytochrome
SVA_RS00185	COG0606	chelatase, subunit chli
SVA_RS00200	COG0347	Belongs to the P(II) protein family
SVA_RS00205	COG0004	ammonium transporteR
SVA_RS00215	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SVA_RS00220	COG1166	arginine decarboxylase activity
SVA_RS00230	COG0018	arginyl-trna synthetase
SVA_RS00270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SVA_RS00275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SVA_RS00280	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SVA_RS00285	COG0069	glutamate synthase activity
SVA_RS00285	COG0067	glutamate synthase
SVA_RS00285	COG0070	glutamate synthase
SVA_RS00290	COG0493	'glutamate synthase
SVA_RS00295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SVA_RS00330	COG0446	pyridine nucleotide-disulphide oxidoreductase
SVA_RS00345	COG3001	Fructosamine kinase
SVA_RS00350	COG5001	Diguanylate cyclase
SVA_RS00350	COG3300	MHYT domain
SVA_RS00355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SVA_RS00365	COG1309	transcriptional regulator
SVA_RS00405	COG1981	membrane
SVA_RS00425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SVA_RS00430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SVA_RS00430	COG2169	Transcriptional regulator
SVA_RS00435	COG0697	spore germination
SVA_RS00440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SVA_RS00460	COG1561	YicC-like family, N-terminal region
SVA_RS00470	COG1758	RNA polymerase activity
SVA_RS00475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SVA_RS00485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SVA_RS00495	COG3161	chorismate lyase activity
SVA_RS00500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SVA_RS00505	COG0625	glutathione transferase activity
SVA_RS00570	COG4941	Belongs to the sigma-70 factor family
SVA_RS00580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SVA_RS00585	COG1024	Enoyl-CoA hydratase
SVA_RS00590	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SVA_RS00590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SVA_RS00600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SVA_RS00605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SVA_RS00610	COG0247	lactate metabolic process
SVA_RS00610	COG0277	FAD linked oxidase domain protein
SVA_RS00615	COG1802	Transcriptional regulator
SVA_RS00620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SVA_RS00635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SVA_RS00680	COG1178	ABC-type Fe3 transport system permease component
SVA_RS00685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SVA_RS00690	COG0509	glycine decarboxylation via glycine cleavage system
SVA_RS00695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SVA_RS00700	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SVA_RS00705	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SVA_RS00710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SVA_RS00715	COG0515	serine threonine protein kinase
SVA_RS00725	COG1331	Highly conserved protein containing a thioredoxin domain
SVA_RS00750	COG1012	belongs to the aldehyde dehydrogenase family
SVA_RS00755	COG0741	lytic transglycosylase activity
SVA_RS00770	COG0617	tRNA 3'-terminal CCA addition
SVA_RS00780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SVA_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
SVA_RS00800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SVA_RS00805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SVA_RS00810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SVA_RS00815	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SVA_RS00820	COG1610	YqeY-like protein
SVA_RS00845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SVA_RS00850	COG0321	lipoyl(octanoyl) transferase activity
SVA_RS00855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SVA_RS00860	COG1686	Belongs to the peptidase S11 family
SVA_RS00870	COG2951	lytic endotransglycosylase activity
SVA_RS00875	COG0772	Belongs to the SEDS family
SVA_RS00880	COG0768	penicillin binding
SVA_RS00885	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
SVA_RS00890	COG1792	Involved in formation and maintenance of cell shape
SVA_RS00895	COG1077	Cell shape determining protein MreB Mrl
SVA_RS00900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SVA_RS00905	COG0154	amidase activity
SVA_RS00910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SVA_RS00945	COG0348	domain, Protein
SVA_RS00960	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SVA_RS00965	COG4191	Histidine kinase
SVA_RS00970	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
SVA_RS00975	COG2915	High frequency lysogenization protein hflD homolog
SVA_RS01025	COG0850	regulation of cytokinetic process
SVA_RS01030	COG2894	cell division
SVA_RS01035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SVA_RS01080	COG0543	2 iron, 2 sulfur cluster binding
SVA_RS01080	COG0493	'glutamate synthase
SVA_RS01085	COG0315	cyclic pyranopterin monophosphate synthase activity
SVA_RS01090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SVA_RS01100	COG0303	'Molybdopterin
SVA_RS01105	COG0430	RNA-3'-phosphate cyclase activity
SVA_RS01135	COG1272	protein, Hemolysin III
SVA_RS01140	COG0277	FAD linked oxidase domain protein
SVA_RS01145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SVA_RS01145	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SVA_RS01145	COG0674	pyruvate-flavodoxin oxidoreductase activity
SVA_RS01145	COG1013	pyruvate-flavodoxin oxidoreductase activity
SVA_RS01150	COG0674	pyruvate-flavodoxin oxidoreductase activity
SVA_RS01150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SVA_RS01150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SVA_RS01150	COG1013	pyruvate-flavodoxin oxidoreductase activity
SVA_RS01180	COG1612	heme a metabolic process
SVA_RS01210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SVA_RS01225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SVA_RS01235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SVA_RS01260	COG2221	Nitrite and sulphite reductase 4Fe-4S
SVA_RS01265	COG2221	Nitrite and sulphite reductase 4Fe-4S
SVA_RS01285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SVA_RS01285	COG0543	2 iron, 2 sulfur cluster binding
SVA_RS01290	COG5001	Diguanylate cyclase
SVA_RS01290	COG1716	ATPase activity
SVA_RS01300	COG3663	DNA glycosylase
SVA_RS01345	COG2258	MOSC domain
SVA_RS01385	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SVA_RS01395	COG1902	pentaerythritol trinitrate reductase activity
SVA_RS01415	COG0697	spore germination
SVA_RS01440	COG3954	Phosphoribulokinase
SVA_RS01450	COG0412	Dienelactone hydrolase
SVA_RS01475	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SVA_RS01480	COG1704	LemA family
SVA_RS01485	COG0483	inositol monophosphate 1-phosphatase activity
SVA_RS01495	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SVA_RS01550	COG0384	phenazine biosynthesis protein PhzF
SVA_RS01565	COG0473	3-isopropylmalate dehydrogenase activity
SVA_RS01615	COG0666	response to abiotic stimulus
SVA_RS01645	COG1028	Short-chain dehydrogenase reductase Sdr
SVA_RS01670	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SVA_RS01675	COG1116	anion transmembrane transporter activity
SVA_RS01680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SVA_RS01685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SVA_RS01710	COG2010	Cytochrome c
SVA_RS01740	COG0535	radical SAM domain protein
SVA_RS01745	COG2920	part of a sulfur-relay system
SVA_RS01765	COG0826	peptidase U32
SVA_RS01770	COG0826	peptidase U32
SVA_RS01775	COG0095	Lipoate-protein ligase
SVA_RS01780	COG3154	lipid carrier protein
SVA_RS01785	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SVA_RS01790	COG2832	Protein of unknown function (DUF454)
SVA_RS01810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SVA_RS01815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SVA_RS01825	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SVA_RS01835	COG0205	6-phosphofructokinase activity
SVA_RS01845	COG0563	adenylate kinase activity
SVA_RS01855	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SVA_RS01860	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SVA_RS01865	COG0316	Belongs to the HesB IscA family
SVA_RS01870	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SVA_RS01875	COG5001	Diguanylate cyclase
SVA_RS01875	COG5002	protein histidine kinase activity
SVA_RS01880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SVA_RS01895	COG1217	gtp-binding protein TYPA
SVA_RS01905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SVA_RS01920	COG0248	Ppx GppA phosphatase
SVA_RS01930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SVA_RS01935	COG0704	Plays a role in the regulation of phosphate uptake
SVA_RS01940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SVA_RS01945	COG0581	inorganic phosphate transmembrane transporter activity
SVA_RS01950	COG0573	inorganic phosphate transmembrane transporter activity
SVA_RS01955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SVA_RS01970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SVA_RS01990	COG0745	RESPONSE REGULATOR receiver
SVA_RS02000	COG2226	methyltransferase
SVA_RS02010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SVA_RS02025	COG2861	carbohydrate metabolic process
SVA_RS02030	COG0793	Belongs to the peptidase S41A family
SVA_RS02035	COG4942	peptidase
SVA_RS02040	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SVA_RS02045	COG0640	Transcriptional regulator
SVA_RS02050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SVA_RS02060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SVA_RS02065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SVA_RS02075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SVA_RS02080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SVA_RS02090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SVA_RS02095	COG1459	type II secretion system
SVA_RS02155	COG3267	Type II secretory pathway component ExeA
SVA_RS02155	COG3409	Peptidoglycan-binding domain 1 protein
SVA_RS02165	COG1040	competence protein
SVA_RS02195	COG0156	8-amino-7-oxononanoate synthase activity
SVA_RS02200	COG2267	carboxylic ester hydrolase activity
SVA_RS02210	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SVA_RS02225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SVA_RS02230	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
SVA_RS02240	COG3346	SURF1 family
SVA_RS02255	COG0109	protoheme IX farnesyltransferase activity
SVA_RS02265	COG0433	COG0433 Predicted ATPase
SVA_RS02270	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SVA_RS02275	COG0247	lactate metabolic process
SVA_RS02280	COG0277	FAD linked oxidase domain protein
SVA_RS02285	COG0277	FAD linked oxidase domain protein
SVA_RS02300	COG1414	Transcriptional regulator
SVA_RS02310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SVA_RS02325	COG0515	serine threonine protein kinase
SVA_RS02325	COG2815	serine threonine protein kinase
SVA_RS02335	COG2177	Part of the ABC transporter FtsEX involved in
SVA_RS02340	COG2884	Cell division ATP-binding protein ftsE
SVA_RS02345	COG0552	protein localization to endoplasmic reticulum
SVA_RS02350	COG0612	Peptidase, M16
SVA_RS02355	COG0612	Peptidase, M16
SVA_RS02360	COG0742	ribosomal rna small subunit methyltransferase
SVA_RS02365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SVA_RS02370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SVA_RS02380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SVA_RS02385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SVA_RS02415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SVA_RS02415	COG0543	2 iron, 2 sulfur cluster binding
SVA_RS02430	COG2959	enzyme of heme biosynthesis
SVA_RS02435	COG1587	Uroporphyrinogen-III synthase
SVA_RS02455	COG3275	phosphorelay sensor kinase activity
SVA_RS02460	COG0745	RESPONSE REGULATOR receiver
SVA_RS02460	COG2972	Histidine kinase
SVA_RS02465	COG0165	Argininosuccinate lyase
SVA_RS02500	COG0019	diaminopimelate decarboxylase activity
SVA_RS02505	COG4106	trans-aconitate 2-methyltransferase activity
SVA_RS02510	COG1832	CoA-binding protein
SVA_RS02520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SVA_RS02530	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SVA_RS02555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SVA_RS02575	COG1278	Cold shock
SVA_RS02585	COG0004	ammonium transporteR
SVA_RS02610	COG1047	Peptidyl-prolyl cis-trans
SVA_RS02620	COG0432	Pfam Uncharacterised protein family UPF0047
SVA_RS02630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SVA_RS02635	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SVA_RS02645	COG1515	deoxyribonuclease V activity
SVA_RS02665	COG0515	serine threonine protein kinase
SVA_RS02665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SVA_RS02675	COG2095	MarC family integral membrane protein
SVA_RS02690	COG3360	Dodecin
SVA_RS02710	COG0501	Belongs to the peptidase M48B family
SVA_RS02715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SVA_RS02720	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SVA_RS02735	COG0583	DNA-binding transcription factor activity
SVA_RS02745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SVA_RS02750	COG0071	Belongs to the small heat shock protein (HSP20) family
SVA_RS02755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SVA_RS02765	COG1309	transcriptional regulator
SVA_RS02770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SVA_RS02785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SVA_RS02790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SVA_RS02805	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
SVA_RS02810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SVA_RS02820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SVA_RS02825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SVA_RS02830	COG0193	aminoacyl-tRNA hydrolase activity
SVA_RS02850	COG1702	phosphate starvation-inducible protein PhoH
SVA_RS02855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SVA_RS02860	COG4535	Mg2 and Co2 transporter CorC
SVA_RS02865	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SVA_RS02870	COG4191	Histidine kinase
SVA_RS02895	COG4251	negative regulation of phosphorylation
SVA_RS02900	COG0784	Response regulator, receiver
SVA_RS02905	COG3706	GGDEF domain
SVA_RS02920	COG1408	metallophosphoesterase
SVA_RS02930	COG0495	leucyl-tRNA aminoacylation
SVA_RS02940	COG1466	dna polymerase III delta subunit
SVA_RS02945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SVA_RS02950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SVA_RS02990	COG0312	modulator of DNA gyrase
SVA_RS02995	COG0312	modulator of DNA gyrase
SVA_RS03000	COG2239	Acts as a magnesium transporter
SVA_RS03010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SVA_RS03020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SVA_RS03025	COG1660	Displays ATPase and GTPase activities
SVA_RS03030	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SVA_RS03050	COG1137	ATPase activity
SVA_RS03055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
SVA_RS03065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SVA_RS03095	COG5002	protein histidine kinase activity
SVA_RS03105	COG2176	DNA-directed DNA polymerase activity
SVA_RS03105	COG5002	protein histidine kinase activity
SVA_RS03110	COG2249	NAD(P)H dehydrogenase (quinone) activity
SVA_RS03140	COG3852	Histidine kinase
SVA_RS03160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SVA_RS03175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SVA_RS03180	COG1127	ABC transporter
SVA_RS03185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SVA_RS03190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SVA_RS03205	COG1131	(ABC) transporter
SVA_RS03210	COG0842	Transport permease protein
SVA_RS03215	COG0271	Belongs to the BolA IbaG family
SVA_RS03220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SVA_RS03225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SVA_RS03230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SVA_RS03235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SVA_RS03240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SVA_RS03245	COG0131	Imidazoleglycerol-phosphate dehydratase
SVA_RS03250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SVA_RS03255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SVA_RS03260	COG0107	imidazoleglycerol-phosphate synthase activity
SVA_RS03265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SVA_RS03270	COG0140	phosphoribosyl-ATP diphosphatase activity
SVA_RS03275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SVA_RS03285	COG0805	protein transport
SVA_RS03290	COG1331	Highly conserved protein containing a thioredoxin domain
SVA_RS03300	COG0723	plastoquinol--plastocyanin reductase activity
SVA_RS03305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SVA_RS03310	COG2857	Cytochrome c1
SVA_RS03315	COG0625	glutathione transferase activity
SVA_RS03320	COG2969	positive regulation of protein catabolic process
SVA_RS03325	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SVA_RS03330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SVA_RS03335	COG2823	Periplasmic or secreted lipoprotein
SVA_RS03340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SVA_RS03345	COG0792	nuclease activity
SVA_RS03350	COG3107	peptidoglycan biosynthetic process
SVA_RS03365	COG2001	Belongs to the MraZ family
SVA_RS03370	COG0275	rRNA processing
SVA_RS03375	COG3116	cell division
SVA_RS03390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SVA_RS03395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SVA_RS03400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SVA_RS03405	COG0772	Belongs to the SEDS family
SVA_RS03410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SVA_RS03415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SVA_RS03420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SVA_RS03425	COG1181	Belongs to the D-alanine--D-alanine ligase family
SVA_RS03430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SVA_RS03440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SVA_RS03445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SVA_RS03450	COG0739	heme binding
SVA_RS03455	COG0653	protein targeting
SVA_RS03460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SVA_RS03465	COG0352	thiamine-phosphate diphosphorylase activity
SVA_RS03470	COG0237	dephospho-CoA kinase activity
SVA_RS03475	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SVA_RS03490	COG1592	Rubrerythrin
SVA_RS03520	COG0101	tRNA pseudouridine synthase activity
SVA_RS03525	COG0135	phosphoribosylanthranilate isomerase activity
SVA_RS03530	COG0133	tryptophan synthase activity
SVA_RS03535	COG0159	tryptophan synthase activity
SVA_RS03540	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SVA_RS03545	COG0285	dihydrofolate synthase activity
SVA_RS03570	COG2379	hydroxypyruvate reductase
SVA_RS03580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SVA_RS03585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SVA_RS03590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SVA_RS03595	COG0215	cysteine-tRNA ligase activity
SVA_RS03600	COG0028	Belongs to the TPP enzyme family
SVA_RS03610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SVA_RS03615	COG0688	phosphatidylethanolamine metabolic process
SVA_RS03620	COG1183	phosphatidylcholine synthase activity
SVA_RS03625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SVA_RS03640	COG1573	uracil-dna glycosylase
SVA_RS03650	COG0438	transferase activity, transferring glycosyl groups
SVA_RS03655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SVA_RS03660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SVA_RS03685	COG4941	Belongs to the sigma-70 factor family
SVA_RS03690	COG5507	3-demethylubiquinone-9 3-methyltransferase
SVA_RS03695	COG3795	YCII-related domain
SVA_RS03715	COG3795	YCII-related domain
SVA_RS03780	COG0587	DNA-directed DNA polymerase activity
SVA_RS03785	COG0612	Peptidase, M16
SVA_RS03795	COG1201	RNA secondary structure unwinding
SVA_RS03800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SVA_RS03805	COG0530	calcium, potassium:sodium antiporter activity
SVA_RS03825	COG0494	nUDIX hydrolase
SVA_RS03835	COG2010	Cytochrome c
SVA_RS03840	COG0058	SHG alpha-glucan phosphorylase activity
SVA_RS03850	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SVA_RS03855	COG0693	protein deglycase activity
SVA_RS03860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SVA_RS03865	COG0438	transferase activity, transferring glycosyl groups
SVA_RS03895	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
SVA_RS03910	COG0577	efflux transmembrane transporter activity
SVA_RS03920	COG2132	Multicopper oxidase
SVA_RS03935	COG0730	response to heat
SVA_RS03960	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SVA_RS03965	COG1012	belongs to the aldehyde dehydrogenase family
SVA_RS03970	COG0318	PFAM AMP-dependent synthetase and ligase
SVA_RS03980	COG3181	Tripartite tricarboxylate transporter family receptor
SVA_RS03995	COG1609	Transcriptional regulator
SVA_RS04000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SVA_RS04025	COG0574	Belongs to the PEP-utilizing enzyme family
SVA_RS04025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SVA_RS04055	COG1295	ribonuclease BN
SVA_RS04095	COG1999	signal sequence binding
SVA_RS04125	COG2226	methyltransferase
SVA_RS04155	COG0300	oxidoreductase activity
SVA_RS04210	COG0330	HflC and HflK could
SVA_RS04220	COG2239	Acts as a magnesium transporter
SVA_RS04225	COG2205	protein histidine kinase activity
SVA_RS04265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SVA_RS04295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SVA_RS04295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SVA_RS04315	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SVA_RS04335	COG2824	Alkylphosphonate utilization operon protein PhnA
SVA_RS04350	COG2733	membrane
SVA_RS04355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SVA_RS04385	COG1360	Flagellar Motor Protein
SVA_RS04400	COG3706	GGDEF domain
SVA_RS04410	COG0705	Rhomboid family
SVA_RS04420	COG0217	transcriptional regulatory protein
SVA_RS04440	COG1174	glycine betaine transport
SVA_RS04450	COG0432	Pfam Uncharacterised protein family UPF0047
SVA_RS04485	COG1716	ATPase activity
SVA_RS04530	COG1295	ribonuclease BN
SVA_RS04540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SVA_RS04560	COG1132	(ABC) transporter
SVA_RS04570	COG3256	nitric oxide reductase
SVA_RS04575	COG0714	Associated with various cellular activities
SVA_RS04585	COG1119	ATPase activity
SVA_RS04590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SVA_RS04690	COG3485	protocatechuate 3,4-dioxygenase
SVA_RS04695	COG3202	ADP transmembrane transporter activity
SVA_RS04710	COG0488	(ABC) transporter
SVA_RS04725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SVA_RS04735	COG0586	Pfam SNARE associated Golgi protein
SVA_RS04745	COG0671	phosphoesterase, PA-phosphatase related
SVA_RS04755	COG0563	adenylate kinase activity
SVA_RS04810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SVA_RS04815	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SVA_RS04815	COG2010	Cytochrome c
SVA_RS04830	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SVA_RS04835	COG1074	ATP-dependent DNA helicase activity
SVA_RS04840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SVA_RS04875	COG0724	RNA recognition motif
SVA_RS04890	COG0584	glycerophosphoryl diester phosphodiesterase
SVA_RS04900	COG2918	glutathione biosynthetic process
SVA_RS04915	COG0116	Belongs to the methyltransferase superfamily
SVA_RS04915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SVA_RS04970	COG1611	Belongs to the LOG family
SVA_RS04985	COG4783	chaperone-mediated protein folding
SVA_RS04995	COG2226	methyltransferase
SVA_RS05010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SVA_RS05025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SVA_RS05030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SVA_RS05040	COG0745	RESPONSE REGULATOR receiver
SVA_RS05045	COG5001	Diguanylate cyclase
SVA_RS05045	COG1716	ATPase activity
SVA_RS05055	COG2719	SpoVR family
SVA_RS05060	COG2718	Belongs to the UPF0229 family
SVA_RS05065	COG2766	serine protein kinase
SVA_RS05075	COG1793	dna ligase
SVA_RS05085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SVA_RS05120	COG1454	alcohol dehydrogenase
SVA_RS05135	COG0318	PFAM AMP-dependent synthetase and ligase
SVA_RS05145	COG0513	Belongs to the DEAD box helicase family
SVA_RS05165	COG1970	mechanosensitive ion channel activity
SVA_RS05170	COG3773	Cell wall hydrolase
SVA_RS05180	COG2234	aminopeptidase activity
SVA_RS05195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SVA_RS05205	COG0709	Synthesizes selenophosphate from selenide and ATP
SVA_RS05240	COG0045	succinate-CoA ligase (ADP-forming) activity
SVA_RS05240	COG1042	CoA-binding domain protein
SVA_RS05240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SVA_RS05255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SVA_RS05260	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SVA_RS05280	COG1252	NADH dehydrogenase
SVA_RS05285	COG0210	DNA helicase
SVA_RS05290	COG0525	valine-tRNA ligase activity
SVA_RS05305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SVA_RS05310	COG0795	lipopolysaccharide-transporting ATPase activity
SVA_RS05315	COG0795	lipopolysaccharide-transporting ATPase activity
SVA_RS05320	COG1138	Cytochrome C-type biogenesis protein
SVA_RS05325	COG3088	subunit of a heme lyase
SVA_RS05335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SVA_RS05340	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SVA_RS05345	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SVA_RS05350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SVA_RS05360	COG4133	protoheme IX ABC transporter activity
SVA_RS05405	COG0142	geranyltranstransferase activity
SVA_RS05410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SVA_RS05415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SVA_RS05420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SVA_RS05425	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SVA_RS05430	COG0268	Binds directly to 16S ribosomal RNA
SVA_RS05435	COG0728	peptidoglycan biosynthetic process
SVA_RS05445	COG0196	riboflavin kinase activity
SVA_RS05450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SVA_RS05460	COG1047	Peptidyl-prolyl cis-trans
SVA_RS05465	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SVA_RS05520	COG3854	ATPases associated with a variety of cellular activities
SVA_RS05530	COG1234	tRNA 3'-trailer cleavage
SVA_RS05555	COG3023	N-Acetylmuramoyl-L-alanine amidase
SVA_RS05560	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SVA_RS05570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SVA_RS05580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SVA_RS05585	COG1492	cobalamin metabolic process
SVA_RS05590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SVA_RS05595	COG2096	Adenosyltransferase
SVA_RS05605	COG4206	TonB-dependent receptor
SVA_RS05615	COG5001	Diguanylate cyclase
SVA_RS05620	COG1120	ATPase activity
SVA_RS05625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SVA_RS05635	COG0494	nUDIX hydrolase
SVA_RS05645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SVA_RS05660	COG1070	Carbohydrate kinase
SVA_RS05665	COG1196	nuclear chromosome segregation
SVA_RS05670	COG3115	cell septum assembly
SVA_RS05675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SVA_RS05680	COG1132	(ABC) transporter
SVA_RS05730	COG0604	alcohol dehydrogenase
SVA_RS05735	COG2264	protein methyltransferase activity
SVA_RS05740	COG0531	amino acid
SVA_RS05760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SVA_RS05765	COG0271	Belongs to the BolA IbaG family
SVA_RS05770	COG2350	Protein conserved in bacteria
SVA_RS05775	COG2917	probably involved in intracellular septation
SVA_RS05785	COG0613	PHP domain protein
SVA_RS05790	COG0009	L-threonylcarbamoyladenylate synthase
SVA_RS05795	COG1994	Peptidase M50
SVA_RS05800	COG0180	Tryptophanyl-tRNA synthetase
SVA_RS05805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SVA_RS05810	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SVA_RS05815	COG1187	pseudouridine synthase activity
SVA_RS05820	COG0668	transmembrane transport
SVA_RS05890	COG0515	serine threonine protein kinase
SVA_RS05935	COG3813	Protein conserved in bacteria
SVA_RS05940	COG0583	DNA-binding transcription factor activity
SVA_RS05970	COG0861	Integral membrane protein TerC family
SVA_RS05985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SVA_RS05995	COG1595	DNA-templated transcription, initiation
SVA_RS06010	COG3220	belongs to the UPF0276 family
SVA_RS06050	COG1473	amidohydrolase
SVA_RS06055	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SVA_RS06065	COG0410	ABC transporter
SVA_RS06080	COG0559	Belongs to the binding-protein-dependent transport system permease family
SVA_RS06100	COG0723	plastoquinol--plastocyanin reductase activity
SVA_RS06100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SVA_RS06110	COG2814	Major facilitator Superfamily
SVA_RS06130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SVA_RS06145	COG3695	enzyme binding
SVA_RS06150	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SVA_RS06155	COG2226	methyltransferase
SVA_RS06175	COG1917	Cupin 2, conserved barrel domain protein
SVA_RS06175	COG4977	sequence-specific DNA binding
SVA_RS06195	COG1404	Belongs to the peptidase S8 family
SVA_RS06200	COG0646	methionine synthase
SVA_RS06200	COG1410	methionine synthase
SVA_RS06210	COG1181	Belongs to the D-alanine--D-alanine ligase family
SVA_RS06235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SVA_RS06240	COG2814	Major facilitator Superfamily
SVA_RS06255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SVA_RS06260	COG0066	3-isopropylmalate dehydratase activity
SVA_RS06265	COG0473	3-isopropylmalate dehydrogenase activity
SVA_RS06290	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SVA_RS06310	COG0166	Belongs to the GPI family
SVA_RS06315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SVA_RS06345	COG0544	peptidyl-prolyl cis-trans isomerase activity
SVA_RS06350	COG0740	serine-type endopeptidase activity
SVA_RS06355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SVA_RS06360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SVA_RS06375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SVA_RS06390	COG0601	transmembrane transport
SVA_RS06395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SVA_RS06405	COG1388	LysM domain
SVA_RS06405	COG0741	lytic transglycosylase activity
SVA_RS06410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SVA_RS06420	COG0328	RNA-DNA hybrid ribonuclease activity
SVA_RS06435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SVA_RS06440	COG1131	(ABC) transporter
SVA_RS06460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SVA_RS06465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SVA_RS06470	COG0484	heat shock protein binding
SVA_RS06495	COG3409	Peptidoglycan-binding domain 1 protein
SVA_RS06495	COG3267	Type II secretory pathway component ExeA
SVA_RS06500	COG0367	asparagine synthase
SVA_RS06505	COG0318	PFAM AMP-dependent synthetase and ligase
SVA_RS06515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SVA_RS06525	COG0438	transferase activity, transferring glycosyl groups
SVA_RS06545	COG1216	Glycosyl transferase, family 2
SVA_RS06550	COG0726	polysaccharide deacetylase
SVA_RS06580	COG0438	transferase activity, transferring glycosyl groups
SVA_RS06625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SVA_RS06665	COG2151	metal-sulfur cluster biosynthetic enzyme
SVA_RS06670	COG1959	2 iron, 2 sulfur cluster binding
SVA_RS06680	COG0372	Belongs to the citrate synthase family
SVA_RS06685	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SVA_RS06710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SVA_RS06715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SVA_RS06720	COG1056	cytidyltransferase-related domain
SVA_RS06720	COG1051	belongs to the nudix hydrolase family
SVA_RS06745	COG3267	Type II secretory pathway component ExeA
SVA_RS06745	COG3409	Peptidoglycan-binding domain 1 protein
SVA_RS06755	COG0517	IMP dehydrogenase activity
SVA_RS06770	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SVA_RS06790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SVA_RS06800	COG1950	PFAM Membrane protein of
SVA_RS06805	COG1628	Protein of unknown function DUF99
SVA_RS06810	COG5001	Diguanylate cyclase
SVA_RS06815	COG0179	Fumarylacetoacetate (FAA) hydrolase
SVA_RS06820	COG2326	polyphosphate kinase activity
SVA_RS06845	COG0668	transmembrane transport
SVA_RS06860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SVA_RS06865	COG0435	Glutathione S-transferase
SVA_RS06870	COG2259	Doxx family
SVA_RS06880	COG1902	pentaerythritol trinitrate reductase activity
SVA_RS06885	COG1741	Belongs to the pirin family
SVA_RS06890	COG0583	DNA-binding transcription factor activity
SVA_RS06910	COG0110	maltose O-acetyltransferase activity
SVA_RS06915	COG3245	cytochrome
SVA_RS06960	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SVA_RS06980	COG1199	ATP-dependent helicase activity
SVA_RS06995	COG0729	surface antigen
SVA_RS07000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SVA_RS07005	COG0531	amino acid
SVA_RS07010	COG0318	PFAM AMP-dependent synthetase and ligase
SVA_RS07035	COG0730	response to heat
SVA_RS07045	COG1546	Belongs to the CinA family
SVA_RS07055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SVA_RS07065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SVA_RS07070	COG2137	regulation of response to DNA damage stimulus
SVA_RS07075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SVA_RS07080	COG0527	aspartate kinase activity
SVA_RS07085	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SVA_RS07120	COG2204	response regulator
SVA_RS07135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SVA_RS07165	COG0438	transferase activity, transferring glycosyl groups
SVA_RS07185	COG3420	alginic acid biosynthetic process
SVA_RS07190	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SVA_RS07195	COG2210	Belongs to the sulfur carrier protein TusA family
SVA_RS07205	COG3409	Peptidoglycan-binding domain 1 protein
SVA_RS07205	COG3267	Type II secretory pathway component ExeA
SVA_RS07210	COG0489	protein tyrosine kinase activity
SVA_RS07225	COG1596	polysaccharide export
SVA_RS07245	COG4106	trans-aconitate 2-methyltransferase activity
SVA_RS07255	COG3551	Protein conserved in bacteria
SVA_RS07260	COG0457	Tetratricopeptide repeat
SVA_RS07290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SVA_RS07295	COG0366	Alpha amylase catalytic
SVA_RS07305	COG0366	Alpha amylase catalytic
SVA_RS07320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SVA_RS07325	COG1640	4-alpha-glucanotransferase
SVA_RS07335	COG5001	Diguanylate cyclase
SVA_RS07335	COG5002	protein histidine kinase activity
SVA_RS07340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SVA_RS07350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SVA_RS07355	COG0463	Glycosyl transferase, family 2
SVA_RS07355	COG1216	Glycosyl transferase, family 2
SVA_RS07360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SVA_RS07380	COG0489	protein tyrosine kinase activity
SVA_RS07385	COG3409	Peptidoglycan-binding domain 1 protein
SVA_RS07385	COG3267	Type II secretory pathway component ExeA
SVA_RS07390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SVA_RS07395	COG0579	oxidoreductase
SVA_RS07400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SVA_RS07410	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SVA_RS07415	COG4310	Domain of unknown function (DUF2172)
SVA_RS07420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SVA_RS07445	COG1216	Glycosyl transferase, family 2
SVA_RS07460	COG1215	transferase activity, transferring glycosyl groups
SVA_RS07475	COG0110	maltose O-acetyltransferase activity
SVA_RS07485	COG0367	asparagine synthase
SVA_RS07500	COG0367	asparagine synthase
SVA_RS07515	COG1216	Glycosyl transferase, family 2
SVA_RS07520	COG1216	Glycosyl transferase, family 2
SVA_RS07520	COG0463	Glycosyl transferase, family 2
SVA_RS07535	COG0438	transferase activity, transferring glycosyl groups
SVA_RS07540	COG0367	asparagine synthase
SVA_RS07545	COG0673	inositol 2-dehydrogenase activity
SVA_RS07585	COG0745	RESPONSE REGULATOR receiver
SVA_RS07635	COG0297	glycogen (starch) synthase activity
SVA_RS07660	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SVA_RS07675	COG0316	Belongs to the HesB IscA family
SVA_RS07680	COG1959	2 iron, 2 sulfur cluster binding
SVA_RS07685	COG0719	Fe-S assembly protein
SVA_RS07690	COG0396	ATPase activity
SVA_RS07695	COG0719	Fe-S assembly protein
SVA_RS07700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SVA_RS07705	COG0822	iron-sulfur transferase activity
SVA_RS07710	COG2151	metal-sulfur cluster biosynthetic enzyme
SVA_RS07720	COG0105	UTP biosynthetic process
SVA_RS07725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SVA_RS07735	COG1426	Protein conserved in bacteria
SVA_RS07740	COG0124	histidyl-tRNA synthetase
SVA_RS07745	COG2976	Protein conserved in bacteria
SVA_RS07750	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SVA_RS07755	COG1160	GTP binding
SVA_RS07760	COG2815	serine threonine protein kinase
SVA_RS07760	COG0515	serine threonine protein kinase
SVA_RS07770	COG1570	exodeoxyribonuclease VII activity
SVA_RS07785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SVA_RS07785	COG0519	Catalyzes the synthesis of GMP from XMP
SVA_RS07795	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SVA_RS07820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SVA_RS07825	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SVA_RS07830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SVA_RS07835	COG1028	Short-chain dehydrogenase reductase Sdr
SVA_RS07840	COG2154	pterin-4-alpha-carbinolamine dehydratase
SVA_RS07850	COG0501	Belongs to the peptidase M48B family
SVA_RS07855	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SVA_RS07870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SVA_RS07870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SVA_RS07875	COG0802	atpase or kinase
SVA_RS07880	COG0860	N-Acetylmuramoyl-L-alanine amidase
SVA_RS07885	COG0733	neurotransmitter:sodium symporter activity
SVA_RS07890	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SVA_RS07895	COG0024	Methionine aminopeptidase
SVA_RS07900	COG0052	Belongs to the universal ribosomal protein uS2 family
SVA_RS07905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SVA_RS07915	COG0233	cytoplasmic translational termination
SVA_RS07920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SVA_RS07925	COG0575	Belongs to the CDS family
SVA_RS07930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SVA_RS07955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SVA_RS07960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SVA_RS07965	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SVA_RS08035	COG0587	DNA-directed DNA polymerase activity
SVA_RS08040	COG0825	malonyl-CoA metabolic process
SVA_RS08045	COG0037	tRNA processing
SVA_RS08050	COG0504	CTP synthase activity
SVA_RS08055	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SVA_RS08060	COG0148	phosphopyruvate hydratase activity
SVA_RS08065	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SVA_RS08080	COG2855	membrane
SVA_RS08090	COG2009	succinate dehydrogenase
SVA_RS08100	COG1053	succinate dehydrogenase
SVA_RS08105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SVA_RS08110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SVA_RS08120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SVA_RS08135	COG3026	antisigma factor binding
SVA_RS08140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SVA_RS08145	COG0481	GTPase activity
SVA_RS08150	COG0681	Belongs to the peptidase S26 family
SVA_RS08160	COG0571	ribonuclease III activity
SVA_RS08165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SVA_RS08170	COG1381	Involved in DNA repair and RecF pathway recombination
SVA_RS08175	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SVA_RS08180	COG0736	holo-[acyl-carrier-protein] synthase activity
SVA_RS08210	COG0436	Aminotransferase
SVA_RS08220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SVA_RS08230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SVA_RS08235	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SVA_RS08240	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SVA_RS08250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SVA_RS08255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SVA_RS08255	COG0072	phenylalanine-tRNA ligase activity
SVA_RS08275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SVA_RS08280	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SVA_RS08300	COG0436	Aminotransferase
SVA_RS08310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SVA_RS08320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SVA_RS08335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SVA_RS08345	COG1472	Belongs to the glycosyl hydrolase 3 family
SVA_RS08350	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SVA_RS08355	COG1573	uracil-dna glycosylase
SVA_RS08360	COG0322	excinuclease ABC activity
SVA_RS08365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SVA_RS08410	COG3265	gluconokinase activity
SVA_RS08415	COG0366	Alpha amylase catalytic
SVA_RS08420	COG2323	membrane
SVA_RS08450	COG0438	transferase activity, transferring glycosyl groups
SVA_RS08455	COG1028	Short-chain dehydrogenase reductase Sdr
SVA_RS08460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SVA_RS08465	COG0859	PFAM glycosyl transferase family 9
SVA_RS08470	COG2192	nodulation
SVA_RS08485	COG0859	PFAM glycosyl transferase family 9
SVA_RS08500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SVA_RS08535	COG2205	protein histidine kinase activity
SVA_RS08580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SVA_RS08580	COG2205	protein histidine kinase activity
SVA_RS08630	COG1088	dTDP-glucose 4,6-dehydratase activity
SVA_RS08645	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SVA_RS08655	COG1028	Short-chain dehydrogenase reductase Sdr
SVA_RS08665	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SVA_RS08685	COG0071	Belongs to the small heat shock protein (HSP20) family
SVA_RS08705	COG0446	pyridine nucleotide-disulphide oxidoreductase
SVA_RS08720	COG0842	Transport permease protein
SVA_RS08725	COG0842	Transport permease protein
SVA_RS08730	COG1131	(ABC) transporter
SVA_RS08735	COG1131	(ABC) transporter
SVA_RS08750	COG1309	transcriptional regulator
SVA_RS08765	COG2920	part of a sulfur-relay system
SVA_RS08775	COG1595	DNA-templated transcription, initiation
SVA_RS08780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SVA_RS08785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SVA_RS08800	COG0517	IMP dehydrogenase activity
SVA_RS08815	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SVA_RS08820	COG0513	Belongs to the DEAD box helicase family
SVA_RS08850	COG1671	Belongs to the UPF0178 family
SVA_RS08865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SVA_RS08865	COG2205	protein histidine kinase activity
SVA_RS08885	COG5001	Diguanylate cyclase
SVA_RS08885	COG3300	MHYT domain
SVA_RS08890	COG0745	RESPONSE REGULATOR receiver
SVA_RS08895	COG1366	Belongs to the anti-sigma-factor antagonist family
SVA_RS08900	COG1366	Belongs to the anti-sigma-factor antagonist family
SVA_RS08905	COG2172	sigma factor antagonist activity
SVA_RS08915	COG5002	protein histidine kinase activity
SVA_RS08915	COG0784	Response regulator, receiver
SVA_RS08915	COG2198	Histidine kinase
SVA_RS08920	COG5002	protein histidine kinase activity
SVA_RS08925	COG2205	protein histidine kinase activity
SVA_RS08960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SVA_RS08975	COG5001	Diguanylate cyclase
SVA_RS08995	COG2084	Dehydrogenase
SVA_RS09020	COG4948	Mandelate Racemase Muconate Lactonizing
SVA_RS09025	COG2188	Transcriptional regulator
SVA_RS09030	COG2721	sulfolactate sulfo-lyase activity
SVA_RS09035	COG2721	sulfolactate sulfo-lyase activity
SVA_RS09065	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SVA_RS09070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SVA_RS09090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SVA_RS09095	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SVA_RS09105	COG1067	ATP-dependent peptidase activity
SVA_RS09115	COG0459	protein refolding
SVA_RS09125	COG1054	Belongs to the UPF0176 family
SVA_RS09135	COG0084	hydrolase, TatD family'
SVA_RS09150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SVA_RS09155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SVA_RS09165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SVA_RS09170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SVA_RS09175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SVA_RS09190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SVA_RS09195	COG0416	fatty acid biosynthetic process
SVA_RS09200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SVA_RS09205	COG1399	metal-binding, possibly nucleic acid-binding protein
SVA_RS09210	COG0439	Biotin carboxylase
SVA_RS09215	COG0511	ligase activity, forming carbon-carbon bonds
SVA_RS09215	COG5016	pyruvate
SVA_RS09220	COG0424	maF-like protein
SVA_RS09225	COG0616	signal peptide processing
SVA_RS09225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SVA_RS09245	COG1530	ribonuclease E activity
SVA_RS09250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SVA_RS09260	COG2835	tetraacyldisaccharide 4'-kinase activity
SVA_RS09260	COG1663	tetraacyldisaccharide 4'-kinase activity
SVA_RS09265	COG1663	tetraacyldisaccharide 4'-kinase activity
SVA_RS09270	COG1132	(ABC) transporter
SVA_RS09275	COG0848	biopolymer transport protein
SVA_RS09280	COG0811	peptide transport
SVA_RS09285	COG2333	competence protein COMEC
SVA_RS09285	COG0658	competence protein
SVA_RS09315	COG0739	heme binding
SVA_RS09320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SVA_RS09330	COG0436	Aminotransferase
SVA_RS09335	COG2171	N-acyltransferase activity
SVA_RS09340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SVA_RS09345	COG0631	protein serine/threonine phosphatase activity
SVA_RS09350	COG1716	ATPase activity
SVA_RS09360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SVA_RS09365	COG0305	Participates in initiation and elongation during chromosome replication
SVA_RS09370	COG0359	binds to the 23S rRNA
SVA_RS09380	COG0360	Binds together with S18 to 16S ribosomal RNA
SVA_RS09385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SVA_RS09390	COG0557	exoribonuclease II activity
SVA_RS09400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SVA_RS09405	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SVA_RS09415	COG0330	HflC and HflK could
SVA_RS09420	COG0330	HflC and HflK could
SVA_RS09425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SVA_RS09430	COG1923	regulation of RNA biosynthetic process
SVA_RS09435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SVA_RS09440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SVA_RS09450	COG0483	inositol monophosphate 1-phosphatase activity
SVA_RS09505	COG3128	pkhd-type hydroxylase
SVA_RS09510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SVA_RS09520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SVA_RS09525	COG2862	Uncharacterized protein family, UPF0114
SVA_RS09530	COG2070	2-Nitropropane dioxygenase
SVA_RS09540	COG2920	part of a sulfur-relay system
SVA_RS09565	COG2221	Nitrite and sulphite reductase 4Fe-4S
SVA_RS09570	COG2221	Nitrite and sulphite reductase 4Fe-4S
SVA_RS09575	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
SVA_RS09580	COG2923	Belongs to the DsrF TusC family
SVA_RS09590	COG2920	part of a sulfur-relay system
SVA_RS09605	COG0493	'glutamate synthase
SVA_RS09625	COG1797	cobyrinic acid a,c-diamide synthase activity
SVA_RS09630	COG0316	Belongs to the HesB IscA family
SVA_RS09635	COG3850	Histidine kinase
SVA_RS09640	COG2197	response regulator
SVA_RS09645	COG1648	precorrin-2 dehydrogenase activity
SVA_RS09645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SVA_RS09655	COG0583	DNA-binding transcription factor activity
SVA_RS09660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SVA_RS09665	COG2198	Histidine kinase
SVA_RS09665	COG2205	protein histidine kinase activity
SVA_RS09665	COG0784	Response regulator, receiver
SVA_RS09670	COG1024	Enoyl-CoA hydratase
SVA_RS09680	COG1215	transferase activity, transferring glycosyl groups
SVA_RS09685	COG0726	polysaccharide deacetylase
SVA_RS09685	COG1649	PFAM Uncharacterised BCR, COG1649
SVA_RS09730	COG0811	peptide transport
SVA_RS09760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SVA_RS09765	COG1993	acr, cog1993
SVA_RS09770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SVA_RS09780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SVA_RS09785	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SVA_RS09795	COG0686	Belongs to the AlaDH PNT family
SVA_RS09800	COG0492	ferredoxin-NADP+ reductase activity
SVA_RS09815	COG3551	Protein conserved in bacteria
SVA_RS09825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SVA_RS09840	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SVA_RS09885	COG1538	Outer membrane efflux protein
SVA_RS09920	COG3209	COG3209 Rhs family protein
SVA_RS09925	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SVA_RS09930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SVA_RS09935	COG1329	Transcriptional regulator
SVA_RS09940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SVA_RS09945	COG0242	peptide deformylase activity
SVA_RS09960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SVA_RS09975	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SVA_RS09985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SVA_RS09990	COG0529	Catalyzes the synthesis of activated sulfate
SVA_RS10000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SVA_RS10010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SVA_RS10015	COG0438	transferase activity, transferring glycosyl groups
SVA_RS10020	COG0367	asparagine synthase
SVA_RS10040	COG2264	protein methyltransferase activity
SVA_RS10045	COG1132	(ABC) transporter
SVA_RS10050	COG0438	transferase activity, transferring glycosyl groups
SVA_RS10055	COG0438	transferase activity, transferring glycosyl groups
SVA_RS10070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SVA_RS10075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SVA_RS10080	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SVA_RS10115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SVA_RS10115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SVA_RS10120	COG1555	photosystem II stabilization
SVA_RS10125	COG0284	orotidine-5'-phosphate decarboxylase activity
SVA_RS10130	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SVA_RS10140	COG0776	regulation of translation
SVA_RS10155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SVA_RS10160	COG0287	Prephenate dehydrogenase
SVA_RS10165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SVA_RS10170	COG1605	Chorismate mutase
SVA_RS10170	COG0077	Prephenate dehydratase
SVA_RS10175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SVA_RS10180	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SVA_RS10190	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SVA_RS10195	COG0402	S-adenosylhomocysteine deaminase activity
SVA_RS10200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SVA_RS10205	COG0546	phosphoglycolate phosphatase activity
SVA_RS10210	COG1322	Protein conserved in bacteria
SVA_RS10225	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SVA_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
SVA_RS10240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SVA_RS10245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SVA_RS10250	COG0471	metal ion transport
SVA_RS10250	COG3273	potassium ion transport
SVA_RS10260	COG4536	flavin adenine dinucleotide binding
SVA_RS10265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SVA_RS10270	COG0501	Belongs to the peptidase M48B family
SVA_RS10280	COG1214	PFAM Peptidase M22, glycoprotease
SVA_RS10300	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SVA_RS10305	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SVA_RS10310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SVA_RS10315	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SVA_RS10325	COG0515	serine threonine protein kinase
SVA_RS10325	COG2815	serine threonine protein kinase
SVA_RS10340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SVA_RS10340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SVA_RS10345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SVA_RS10350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SVA_RS10355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SVA_RS10360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SVA_RS10365	COG1862	Preprotein translocase
SVA_RS10370	COG0343	queuine tRNA-ribosyltransferase activity
SVA_RS10375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SVA_RS10390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SVA_RS10395	COG0297	glycogen (starch) synthase activity
SVA_RS10405	COG1543	Belongs to the glycosyl hydrolase 57 family
SVA_RS10410	COG1295	ribonuclease BN
SVA_RS10420	COG0837	glucose binding
SVA_RS10430	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SVA_RS10435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SVA_RS10440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SVA_RS10445	COG1428	Deoxynucleoside kinase
SVA_RS10450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SVA_RS10455	COG0617	tRNA 3'-terminal CCA addition
SVA_RS10465	COG3118	belongs to the thioredoxin family
SVA_RS10480	COG0720	synthase
SVA_RS10500	COG0436	Aminotransferase
SVA_RS10505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SVA_RS10510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SVA_RS10515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SVA_RS10520	COG1968	undecaprenyl-diphosphatase activity
SVA_RS10535	COG0429	hydrolase of the alpha beta-hydrolase fold
SVA_RS10540	COG1643	Atp-dependent helicase
SVA_RS10570	COG1573	uracil-dna glycosylase
SVA_RS10580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SVA_RS10595	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
SVA_RS10605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SVA_RS10635	COG1394	ATPase activity, coupled to movement of substances
SVA_RS10640	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SVA_RS10645	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SVA_RS10650	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
SVA_RS10665	COG1269	ATP hydrolysis coupled proton transport
SVA_RS10715	COG0298	carbon dioxide binding
SVA_RS10720	COG0375	protein maturation
SVA_RS10745	COG1368	sulfuric ester hydrolase activity
SVA_RS10760	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SVA_RS10765	COG0642	Histidine kinase
SVA_RS10800	COG5001	Diguanylate cyclase
SVA_RS10800	COG5002	protein histidine kinase activity
SVA_RS10825	COG1872	DUF167
SVA_RS10830	COG2363	Small membrane protein
SVA_RS10890	COG1136	(ABC) transporter
SVA_RS10895	COG4591	ABC-type transport system involved in lipoprotein release permease component
SVA_RS10915	COG2391	methyltransferase activity
SVA_RS10925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SVA_RS10930	COG0542	response to heat
SVA_RS10945	COG0640	Transcriptional regulator
SVA_RS10955	COG1073	alpha beta
SVA_RS10970	COG3263	regulation of cellular component size
SVA_RS10985	COG0564	pseudouridine synthase activity
SVA_RS11005	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SVA_RS11010	COG0045	succinate-CoA ligase (ADP-forming) activity
SVA_RS11015	COG1136	(ABC) transporter
SVA_RS11015	COG0577	efflux transmembrane transporter activity
SVA_RS11055	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SVA_RS11060	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
SVA_RS11065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SVA_RS11070	COG0542	response to heat
SVA_RS11075	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SVA_RS11080	COG1278	Cold shock
SVA_RS11090	COG2224	Isocitrate lyase
SVA_RS11100	COG0482	sulfurtransferase activity
SVA_RS11120	COG0791	NLP P60 protein
SVA_RS11130	COG3118	belongs to the thioredoxin family
SVA_RS11140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SVA_RS11155	COG2226	methyltransferase
SVA_RS11160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SVA_RS11170	COG0326	Molecular chaperone. Has ATPase activity
SVA_RS11230	COG1294	oxidase, subunit
SVA_RS11235	COG1271	oxidase subunit
SVA_RS11240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SVA_RS11250	COG0628	permease
SVA_RS11260	COG2823	Periplasmic or secreted lipoprotein
SVA_RS11285	COG3237	CsbD-like
SVA_RS11290	COG1278	Cold shock
SVA_RS11335	COG2204	response regulator
SVA_RS11345	COG2205	protein histidine kinase activity
SVA_RS11370	COG0129	dihydroxy-acid dehydratase activity
SVA_RS11375	COG0167	dihydroorotate dehydrogenase activity
SVA_RS11390	COG0673	inositol 2-dehydrogenase activity
SVA_RS11395	COG0300	oxidoreductase activity
SVA_RS11445	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SVA_RS11450	COG2032	superoxide dismutase activity
SVA_RS11470	COG0437	4 iron, 4 sulfur cluster binding
SVA_RS11475	COG0243	molybdopterin cofactor binding
SVA_RS11475	COG3383	formate dehydrogenase (NAD+) activity
SVA_RS11485	COG3381	protein complex oligomerization
SVA_RS11505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SVA_RS11510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SVA_RS11530	COG3852	Histidine kinase
SVA_RS11540	COG3585	molybdate ion transport
SVA_RS11550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SVA_RS11570	COG1763	Mo-molybdopterin cofactor biosynthetic process
SVA_RS11575	COG0303	'Molybdopterin
SVA_RS11580	COG0521	Mo-molybdopterin cofactor biosynthetic process
SVA_RS11585	COG3189	MarR family transcriptional regulator
SVA_RS11595	COG2957	Belongs to the agmatine deiminase family
SVA_RS11610	COG0586	Pfam SNARE associated Golgi protein
SVA_RS11615	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SVA_RS11620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SVA_RS11635	COG0372	Belongs to the citrate synthase family
SVA_RS11640	COG2027	D-alanyl-D-alanine carboxypeptidase
SVA_RS11650	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SVA_RS11655	COG0210	DNA helicase
SVA_RS11680	COG0335	large ribosomal subunit rRNA binding
SVA_RS11685	COG0336	Belongs to the RNA methyltransferase TrmD family
SVA_RS11690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SVA_RS11695	COG0228	four-way junction DNA binding
SVA_RS11700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SVA_RS11710	COG2853	Lipoprotein
SVA_RS11725	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SVA_RS11760	COG0515	serine threonine protein kinase
SVA_RS11765	COG1185	polyribonucleotide nucleotidyltransferase activity
SVA_RS11770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SVA_RS11775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SVA_RS11780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SVA_RS11785	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SVA_RS11790	COG2251	uridine kinase activity
SVA_RS11790	COG0195	Participates in both transcription termination and antitermination
SVA_RS11825	COG1007	ATP synthesis coupled electron transport
SVA_RS11840	COG0713	ATP synthesis coupled electron transport
SVA_RS11850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SVA_RS11855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SVA_RS11865	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SVA_RS11875	COG0649	NAD binding
SVA_RS11880	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SVA_RS11885	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SVA_RS11890	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SVA_RS11900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SVA_RS11905	COG0149	triose-phosphate isomerase activity
SVA_RS11910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SVA_RS11915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SVA_RS11925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SVA_RS11930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SVA_RS11935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SVA_RS11940	COG0505	Belongs to the CarA family
SVA_RS11950	COG1028	Short-chain dehydrogenase reductase Sdr
SVA_RS11960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SVA_RS11965	COG1285	pathogenesis
SVA_RS11970	COG0484	heat shock protein binding
SVA_RS11975	COG0443	Heat shock 70 kDa protein
SVA_RS11980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SVA_RS11985	COG1420	regulation of RNA biosynthetic process
SVA_RS11990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SVA_RS11995	COG0497	DNA recombination
SVA_RS12000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SVA_RS12000	COG0165	Argininosuccinate lyase
SVA_RS12030	COG0735	belongs to the Fur family
SVA_RS12035	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SVA_RS12050	COG0733	neurotransmitter:sodium symporter activity
SVA_RS12055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SVA_RS12070	COG4191	Histidine kinase
SVA_RS12075	COG4566	intracellular signal transduction
SVA_RS12080	COG2855	membrane
SVA_RS12090	COG0588	phosphoglycerate mutase activity
SVA_RS12095	COG4191	Histidine kinase
SVA_RS12100	COG4566	intracellular signal transduction
SVA_RS12110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SVA_RS12120	COG4191	Histidine kinase
SVA_RS12125	COG4566	intracellular signal transduction
SVA_RS12135	COG1959	2 iron, 2 sulfur cluster binding
SVA_RS12140	COG1320	monovalent cation:proton antiporter activity
SVA_RS12145	COG2212	antiporter activity
SVA_RS12150	COG1863	multisubunit Na H antiporter MnhE subunit
SVA_RS12155	COG0651	ATP synthesis coupled electron transport
SVA_RS12160	COG1006	Multisubunit Na H antiporter MnhC subunit
SVA_RS12165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SVA_RS12165	COG2111	Na H antiporter
SVA_RS12170	COG1722	exodeoxyribonuclease VII activity
SVA_RS12175	COG0142	geranyltranstransferase activity
SVA_RS12180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SVA_RS12185	COG1469	GTP cyclohydrolase I activity
SVA_RS12190	COG4797	methyltransferase
SVA_RS12190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SVA_RS12200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SVA_RS12200	COG0519	Catalyzes the synthesis of GMP from XMP
SVA_RS12210	COG1940	carbohydrate kinase activity
SVA_RS12220	COG0442	prolyl-tRNA aminoacylation
SVA_RS12225	COG5001	Diguanylate cyclase
SVA_RS12225	COG5002	protein histidine kinase activity
SVA_RS12230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SVA_RS12235	COG0741	lytic transglycosylase activity
SVA_RS12240	COG1254	Belongs to the acylphosphatase family
SVA_RS12250	COG1538	Outer membrane efflux protein
SVA_RS12295	COG0628	permease
SVA_RS12300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SVA_RS12305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SVA_RS12310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SVA_RS12350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SVA_RS12355	COG2003	Belongs to the UPF0758 family
SVA_RS12360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SVA_RS12375	COG1238	metal cluster binding
SVA_RS12435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SVA_RS12465	COG0784	Response regulator, receiver
SVA_RS12470	COG4251	negative regulation of phosphorylation
SVA_RS12530	COG0628	permease
SVA_RS12545	COG2205	protein histidine kinase activity
SVA_RS12545	COG0784	Response regulator, receiver
SVA_RS12545	COG2198	Histidine kinase
SVA_RS12560	COG1595	DNA-templated transcription, initiation
SVA_RS12580	COG2226	methyltransferase
SVA_RS12590	COG0564	pseudouridine synthase activity
SVA_RS12600	COG3011	Protein conserved in bacteria
SVA_RS12615	COG0583	DNA-binding transcription factor activity
SVA_RS12625	COG2133	pyrroloquinoline quinone binding
SVA_RS12655	COG0583	DNA-binding transcription factor activity
SVA_RS12675	COG0488	(ABC) transporter
SVA_RS12680	COG0739	heme binding
SVA_RS12695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SVA_RS12740	COG1595	DNA-templated transcription, initiation
SVA_RS12785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SVA_RS12800	COG0384	phenazine biosynthesis protein PhzF
SVA_RS12805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SVA_RS12810	COG0741	lytic transglycosylase activity
SVA_RS12835	COG1047	Peptidyl-prolyl cis-trans
SVA_RS12865	COG3132	Protein of unknown function, DUF480
SVA_RS12895	COG1476	TRANSCRIPTIONal
SVA_RS12900	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SVA_RS12925	COG0010	Belongs to the arginase family
SVA_RS12960	COG4977	sequence-specific DNA binding
SVA_RS12960	COG1917	Cupin 2, conserved barrel domain protein
SVA_RS12970	COG1881	PFAM PEBP family protein
SVA_RS12975	COG2226	methyltransferase
SVA_RS12980	COG5002	protein histidine kinase activity
SVA_RS12990	COG0235	Class ii aldolase
SVA_RS13020	COG0577	efflux transmembrane transporter activity
SVA_RS13020	COG1136	(ABC) transporter
SVA_RS13025	COG1136	(ABC) transporter
SVA_RS13025	COG0577	efflux transmembrane transporter activity
SVA_RS13040	COG5002	protein histidine kinase activity
SVA_RS13080	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SVA_RS13080	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SVA_RS13115	COG0514	ATP-dependent DNA helicase (RecQ)
SVA_RS13160	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
SVA_RS13195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SVA_RS13200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SVA_RS13205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SVA_RS13230	COG0583	DNA-binding transcription factor activity
SVA_RS13235	COG0028	Belongs to the TPP enzyme family
SVA_RS13255	COG0247	lactate metabolic process
SVA_RS13275	COG2814	Major facilitator Superfamily
SVA_RS13295	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SVA_RS13305	COG1695	Transcriptional regulator
SVA_RS13315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SVA_RS13325	COG2217	Heavy metal translocating P-type atpase
SVA_RS13395	COG0493	'glutamate synthase
SVA_RS13400	COG0121	glutamine amidotransferase
SVA_RS13415	COG0398	Pfam SNARE associated Golgi protein
SVA_RS13425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SVA_RS13430	COG1104	cysteine desulfurase activity
SVA_RS13445	COG3302	dmso reductase anchor subunit
SVA_RS13455	COG0437	4 iron, 4 sulfur cluster binding
SVA_RS13460	COG0243	molybdopterin cofactor binding
SVA_RS13470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SVA_RS13480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SVA_RS13515	COG0717	Belongs to the dCTP deaminase family
SVA_RS13520	COG0489	protein tyrosine kinase activity
SVA_RS13525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SVA_RS13525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SVA_RS13540	COG3706	GGDEF domain
SVA_RS13565	COG1228	amidohydrolase
SVA_RS13570	COG2878	Part of a membrane complex involved in electron transport
SVA_RS13575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SVA_RS13635	COG3706	GGDEF domain
SVA_RS13640	COG3123	guanosine phosphorylase activity
SVA_RS13655	COG1131	(ABC) transporter
SVA_RS13670	COG0842	Transport permease protein
SVA_RS13675	COG1131	(ABC) transporter
SVA_RS13680	COG3713	MltA-interacting MipA family protein
SVA_RS13695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SVA_RS13700	COG0022	dehydrogenase e1 component
SVA_RS13710	COG2226	methyltransferase
SVA_RS13760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SVA_RS13770	COG3876	Protein conserved in bacteria
SVA_RS13785	COG0417	DNA replication proofreading
SVA_RS13855	COG3239	Fatty acid desaturase
SVA_RS13870	COG2226	methyltransferase
SVA_RS13935	COG0583	DNA-binding transcription factor activity
SVA_RS13950	COG0545	Peptidyl-prolyl cis-trans isomerase
SVA_RS13980	COG2226	methyltransferase
SVA_RS14030	COG2226	methyltransferase
SVA_RS14060	COG0596	Alpha beta hydrolase
SVA_RS14065	COG0861	Integral membrane protein TerC family
SVA_RS14080	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
SVA_RS14085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SVA_RS14105	COG0137	argininosuccinate synthase activity
SVA_RS14125	COG0137	argininosuccinate synthase activity
SVA_RS14140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SVA_RS14145	COG0022	dehydrogenase e1 component
SVA_RS14145	COG0508	dehydrogenase complex catalyzes the overall conversion of
SVA_RS14150	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SVA_RS14155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SVA_RS14175	COG1126	abc transporter atp-binding protein
SVA_RS14180	COG0765	amino acid transport
SVA_RS14185	COG0765	amino acid transport
SVA_RS14190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SVA_RS14210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SVA_RS14215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SVA_RS14220	COG3842	ATPase activity
SVA_RS14225	COG5001	Diguanylate cyclase
SVA_RS14225	COG5002	protein histidine kinase activity
SVA_RS14230	COG0488	(ABC) transporter
SVA_RS14240	COG3220	belongs to the UPF0276 family
SVA_RS14250	COG0243	molybdopterin cofactor binding
SVA_RS14260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SVA_RS14265	COG1116	anion transmembrane transporter activity
SVA_RS14270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SVA_RS14275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SVA_RS14275	COG1116	anion transmembrane transporter activity
SVA_RS14290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SVA_RS14305	COG5265	(ABC) transporter
SVA_RS14315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SVA_RS14315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SVA_RS14345	COG3864	Putative metallopeptidase domain
SVA_RS14360	COG0739	heme binding
SVA_RS14360	COG0741	lytic transglycosylase activity
SVA_RS14360	COG1196	nuclear chromosome segregation
SVA_RS14375	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SVA_RS14395	COG0363	glucosamine-6-phosphate deaminase activity
SVA_RS14400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SVA_RS14405	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SVA_RS14420	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SVA_RS14490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SVA_RS14490	COG0047	phosphoribosylformylglycinamidine synthase activity
SVA_RS14495	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
SVA_RS14500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SVA_RS14510	COG2133	pyrroloquinoline quinone binding
SVA_RS14515	COG2133	pyrroloquinoline quinone binding
SVA_RS14540	COG2239	Acts as a magnesium transporter
SVA_RS14565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SVA_RS14575	COG1355	regulation of microtubule-based process
SVA_RS14600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SVA_RS14600	COG1796	DNA polymerase
SVA_RS14625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SVA_RS14630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SVA_RS14635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SVA_RS14645	COG0583	DNA-binding transcription factor activity
SVA_RS14675	COG0095	Lipoate-protein ligase
SVA_RS14685	COG0509	glycine decarboxylation via glycine cleavage system
SVA_RS14690	COG2210	Belongs to the sulfur carrier protein TusA family
SVA_RS14695	COG0425	Belongs to the sulfur carrier protein TusA family
SVA_RS14720	COG3258	Cytochrome c
SVA_RS14730	COG3954	Phosphoribulokinase
SVA_RS14810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SVA_RS14825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SVA_RS15030	COG0714	Associated with various cellular activities
SVA_RS15040	COG2003	Belongs to the UPF0758 family
SVA_RS15055	COG0629	single-stranded DNA binding
SVA_RS15080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SVA_RS15140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SVA_RS15205	COG1396	sequence-specific DNA binding
SVA_RS15210	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SVA_RS15215	COG2119	membrane
SVA_RS15250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SVA_RS15265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SVA_RS15270	COG0785	Cytochrome C biogenesis protein
SVA_RS15285	COG2132	Multicopper oxidase
SVA_RS15290	COG1999	signal sequence binding
SVA_RS15305	COG2193	ferroxidase activity
SVA_RS15320	COG4771	TonB-dependent receptor
SVA_RS15325	COG0672	)-iron permease
SVA_RS15360	COG0789	Transcriptional regulator
SVA_RS15370	COG2217	Heavy metal translocating P-type atpase
SVA_RS15385	COG4520	surface antigen
SVA_RS15405	COG1285	pathogenesis
SVA_RS15420	COG1566	PFAM secretion protein HlyD family protein
SVA_RS15475	COG0784	Response regulator, receiver
SVA_RS15475	COG2205	protein histidine kinase activity
SVA_RS15490	COG2132	Multicopper oxidase
SVA_RS15520	COG0058	SHG alpha-glucan phosphorylase activity
SVA_RS15530	COG1554	hydrolase, family 65, central catalytic
SVA_RS15535	COG0406	alpha-ribazole phosphatase activity
SVA_RS15540	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SVA_RS15570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SVA_RS15580	COG2116	formate transmembrane transporter activity
SVA_RS15595	COG2217	Heavy metal translocating P-type atpase
SVA_RS15605	COG2132	Multicopper oxidase
SVA_RS15610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SVA_RS15630	COG0789	Transcriptional regulator
SVA_RS15640	COG0033	Phosphoglucomutase
SVA_RS15660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SVA_RS15665	COG2204	response regulator
SVA_RS15690	COG3047	cAMP biosynthetic process
SVA_RS15740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SVA_RS15770	COG0201	protein transport
SVA_RS15780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SVA_RS15805	COG1013	pyruvate-flavodoxin oxidoreductase activity
SVA_RS15810	COG0674	pyruvate-flavodoxin oxidoreductase activity
SVA_RS15855	COG0723	plastoquinol--plastocyanin reductase activity
SVA_RS15860	COG3344	reverse transcriptase
SVA_RS15865	COG0642	Histidine kinase
SVA_RS15935	COG2205	protein histidine kinase activity
SVA_RS15935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SVA_RS15940	COG0842	Transport permease protein
SVA_RS15945	COG0842	Transport permease protein
SVA_RS15950	COG1131	(ABC) transporter
SVA_RS16020	COG2217	Heavy metal translocating P-type atpase
SVA_RS16040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SVA_RS16050	COG0789	Transcriptional regulator
SVA_RS16075	COG0121	glutamine amidotransferase
SVA_RS16080	COG0789	Transcriptional regulator
SVA_RS16150	COG0582	viral genome integration into host DNA
SVA_RS16230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SVA_RS16235	COG0602	queuosine metabolic process
SVA_RS16250	COG0823	Involved in the tonB-independent uptake of proteins
SVA_RS16270	COG0824	Thioesterase
SVA_RS16275	COG2255	four-way junction helicase activity
SVA_RS16280	COG0632	four-way junction helicase activity
SVA_RS16285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SVA_RS16290	COG0217	transcriptional regulatory protein
SVA_RS16300	COG1051	belongs to the nudix hydrolase family
SVA_RS16305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SVA_RS16330	COG0537	adenosine 5'-monophosphoramidase activity
SVA_RS16335	COG0629	single-stranded DNA binding
SVA_RS16340	COG2814	Major facilitator Superfamily
SVA_RS16345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SVA_RS16355	COG0203	ribosomal protein L17
SVA_RS16360	COG0202	RNA polymerase activity
SVA_RS16365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SVA_RS16370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SVA_RS16375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SVA_RS16385	COG0201	protein transport
SVA_RS16390	COG0200	Binds to the 23S rRNA
SVA_RS16395	COG1841	ribosomal large subunit assembly
SVA_RS16400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SVA_RS16410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SVA_RS16420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SVA_RS16425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SVA_RS16430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SVA_RS16435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SVA_RS16440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SVA_RS16445	COG0255	Belongs to the universal ribosomal protein uL29 family
SVA_RS16450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SVA_RS16455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SVA_RS16460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SVA_RS16470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SVA_RS16475	COG0089	rRNA binding
SVA_RS16480	COG0088	Forms part of the polypeptide exit tunnel
SVA_RS16485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SVA_RS16490	COG0051	transcription antitermination factor activity, RNA binding
SVA_RS16500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SVA_RS16505	COG0049	tRNA binding
SVA_RS16510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SVA_RS16515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SVA_RS16520	COG0085	RNA polymerase activity
SVA_RS16525	COG0222	ribosome binding
SVA_RS16530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SVA_RS16535	COG0081	regulation of translation
SVA_RS16540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SVA_RS16550	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SVA_RS16580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SVA_RS16595	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SVA_RS16605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SVA_RS16610	COG2084	Dehydrogenase
SVA_RS16615	COG0154	amidase activity
SVA_RS16630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SVA_RS16640	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SVA_RS16645	COG0247	lactate metabolic process
SVA_RS16650	COG1139	Iron-sulfur cluster binding protein
SVA_RS16660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SVA_RS16665	COG0678	peroxiredoxin activity
SVA_RS16675	COG1509	lysine 2,3-aminomutase activity
SVA_RS16680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SVA_RS16690	COG1490	D-aminoacyl-tRNA deacylase activity
SVA_RS16725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SVA_RS16730	COG0739	heme binding
SVA_RS16735	COG0316	Belongs to the HesB IscA family
SVA_RS16750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SVA_RS16770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SVA_RS16780	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SVA_RS16800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SVA_RS16805	COG0512	Glutamine amidotransferase of anthranilate synthase
SVA_RS16810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SVA_RS16815	COG0546	phosphoglycolate phosphatase activity
SVA_RS16850	COG2217	Heavy metal translocating P-type atpase
SVA_RS16855	COG0789	Transcriptional regulator
SVA_RS16885	COG2010	Cytochrome c
SVA_RS16900	COG2132	Multicopper oxidase
SVA_RS16915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SVA_RS16920	COG0651	ATP synthesis coupled electron transport
SVA_RS16935	COG0651	ATP synthesis coupled electron transport
SVA_RS16940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SVA_RS16940	COG0649	NAD binding
SVA_RS16945	COG3260	NADH ubiquinone oxidoreductase 20
SVA_RS16985	COG4451	ribulose bisphosphate carboxylase, small
SVA_RS16990	COG1850	ribulose-bisphosphate carboxylase activity
SVA_RS16995	COG0583	DNA-binding transcription factor activity
SVA_RS17020	COG0288	reversible hydration of carbon dioxide
SVA_RS17045	COG1850	ribulose-bisphosphate carboxylase activity
SVA_RS17070	COG2205	protein histidine kinase activity
SVA_RS17070	COG2198	Histidine kinase
SVA_RS17070	COG0784	Response regulator, receiver
SVA_RS17095	COG3588	fructose-bisphosphate aldolase
SVA_RS17105	COG0126	phosphoglycerate kinase activity
SVA_RS17110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SVA_RS17115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SVA_RS17120	COG0483	inositol monophosphate 1-phosphatase activity
SVA_RS17150	COG0643	Histidine kinase
SVA_RS17150	COG2198	Histidine kinase
SVA_RS17155	COG0840	transmembrane signaling receptor activity
SVA_RS17190	COG1678	Uncharacterized ACR, COG1678
SVA_RS17195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SVA_RS17200	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SVA_RS17205	COG0540	Belongs to the ATCase OTCase family
SVA_RS17235	COG3279	Response regulator of the LytR AlgR family
SVA_RS17240	COG1196	nuclear chromosome segregation
SVA_RS17240	COG0741	lytic transglycosylase activity
SVA_RS17240	COG0739	heme binding
SVA_RS17250	COG4412	M6 family metalloprotease domain protein
SVA_RS17250	COG1404	Belongs to the peptidase S8 family
SVA_RS17280	COG1999	signal sequence binding
SVA_RS17295	COG1450	Type ii and iii secretion system protein
SVA_RS17320	COG2165	general secretion pathway protein
SVA_RS17335	COG1459	type II secretion system
SVA_RS17340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SVA_RS17360	COG2963	transposase activity
SVA_RS17390	COG2223	nitrite transmembrane transporter activity
SVA_RS17395	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SVA_RS17400	COG4181	ATPase activity
SVA_RS17435	COG2833	Protein of unknown function (DUF455)
SVA_RS17460	COG0708	Exodeoxyribonuclease III
SVA_RS17465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SVA_RS17490	COG2046	Belongs to the sulfate adenylyltransferase family
SVA_RS17505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SVA_RS17555	COG2010	Cytochrome c
SVA_RS17570	COG3278	Belongs to the heme-copper respiratory oxidase family
SVA_RS17585	COG3047	cAMP biosynthetic process
SVA_RS17590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SVA_RS17595	COG2217	Heavy metal translocating P-type atpase
SVA_RS17630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SVA_RS17645	COG2863	cytochrome
SVA_RS17650	COG0446	pyridine nucleotide-disulphide oxidoreductase
SVA_RS17655	COG0783	Belongs to the Dps family
SVA_RS17665	COG0753	catalase activity
SVA_RS17670	COG0583	DNA-binding transcription factor activity
SVA_RS17685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SVA_RS17695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SVA_RS17705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SVA_RS17715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SVA_RS17720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SVA_RS17725	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SVA_RS17730	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SVA_RS17745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SVA_RS17755	COG0751	glycine-tRNA ligase activity
SVA_RS17760	COG0752	glycyl-tRNA synthetase alpha subunit
SVA_RS17765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SVA_RS17780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SVA_RS17785	COG0174	glutamine synthetase
SVA_RS17790	COG3852	Histidine kinase
SVA_RS17795	COG2204	response regulator
SVA_RS17835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SVA_RS17840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SVA_RS17845	COG0006	proline dipeptidase activity
SVA_RS17885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SVA_RS17890	COG1692	metallophosphoesterase
SVA_RS17900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SVA_RS17905	COG4191	Histidine kinase
SVA_RS17905	COG0784	Response regulator, receiver
SVA_RS17915	COG2020	methyltransferase activity
SVA_RS17925	COG2226	methyltransferase
SVA_RS17945	COG1253	flavin adenine dinucleotide binding
SVA_RS17970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SVA_RS17975	COG1376	ErfK ybiS ycfS ynhG family protein
SVA_RS17985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SVA_RS17990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SVA_RS17995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SVA_RS18000	COG5002	protein histidine kinase activity
SVA_RS18015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SVA_RS18030	COG2204	response regulator
SVA_RS18035	COG4191	Histidine kinase
SVA_RS18050	COG3118	belongs to the thioredoxin family
SVA_RS18080	COG1234	tRNA 3'-trailer cleavage
SVA_RS18085	COG5002	protein histidine kinase activity
SVA_RS18085	COG5001	Diguanylate cyclase
SVA_RS18090	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SVA_RS18115	COG2827	Endonuclease containing a URI domain
SVA_RS18120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SVA_RS18130	COG2022	thiamine diphosphate biosynthetic process
SVA_RS18150	COG2982	Protein involved in outer membrane biogenesis
SVA_RS18160	COG1194	a g-specific adenine glycosylase
SVA_RS18165	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
SVA_RS18205	COG5002	protein histidine kinase activity
SVA_RS18205	COG2205	protein histidine kinase activity
SVA_RS18205	COG0784	Response regulator, receiver
SVA_RS18215	COG0745	RESPONSE REGULATOR receiver
SVA_RS18220	COG2205	protein histidine kinase activity
SVA_RS18280	COG0655	NAD(P)H dehydrogenase (quinone) activity
SVA_RS18290	COG2323	membrane
SVA_RS18300	COG0084	hydrolase, TatD family'
SVA_RS18320	COG0109	protoheme IX farnesyltransferase activity
SVA_RS18325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SVA_RS18330	COG5002	protein histidine kinase activity
SVA_RS18360	COG0519	Catalyzes the synthesis of GMP from XMP
SVA_RS18385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SVA_RS18390	COG0318	PFAM AMP-dependent synthetase and ligase
SVA_RS18410	COG0574	Belongs to the PEP-utilizing enzyme family
SVA_RS18410	COG3848	Pyruvate phosphate dikinase
SVA_RS18440	COG1309	transcriptional regulator
SVA_RS18445	COG0204	Acyl-transferase
SVA_RS18445	COG0318	PFAM AMP-dependent synthetase and ligase
SVA_RS18450	COG2814	Major facilitator Superfamily
SVA_RS18455	COG0598	Magnesium transport protein CorA
SVA_RS18485	COG1011	Hydrolase
SVA_RS18490	COG1309	transcriptional regulator
SVA_RS18535	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SVA_RS18550	COG0730	response to heat
SVA_RS18575	COG0259	pyridoxamine-phosphate oxidase activity
SVA_RS18580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SVA_RS18605	COG1538	Outer membrane efflux protein
SVA_RS18630	COG2211	Major facilitator Superfamily
SVA_RS18640	COG1054	Belongs to the UPF0176 family
SVA_RS18645	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SVA_RS18650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SVA_RS18655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SVA_RS18660	COG1538	Outer membrane efflux protein
SVA_RS18675	COG1519	Transferase
SVA_RS18680	COG0438	transferase activity, transferring glycosyl groups
SVA_RS18685	COG0438	transferase activity, transferring glycosyl groups
SVA_RS18690	COG0438	transferase activity, transferring glycosyl groups
SVA_RS18700	COG0275	rRNA processing
SVA_RS18710	COG1215	transferase activity, transferring glycosyl groups
SVA_RS18735	COG0438	transferase activity, transferring glycosyl groups
SVA_RS18760	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SVA_RS18770	COG0459	protein refolding
SVA_RS18775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SVA_RS18785	COG1324	tolerance protein
SVA_RS18790	COG4232	protein-disulfide reductase activity
SVA_RS18795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SVA_RS18800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SVA_RS18805	COG0511	ligase activity, forming carbon-carbon bonds
SVA_RS18810	COG0439	Biotin carboxylase
SVA_RS18815	COG2264	protein methyltransferase activity
SVA_RS18835	COG0138	bifunctional purine biosynthesis protein purh
SVA_RS18845	COG0151	Belongs to the GarS family
SVA_RS18850	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SVA_RS18855	COG0009	L-threonylcarbamoyladenylate synthase
SVA_RS18860	COG0408	coproporphyrinogen oxidase activity
SVA_RS18865	COG1607	acyl-coa hydrolase
SVA_RS18875	COG0330	HflC and HflK could
SVA_RS18885	COG0235	Class ii aldolase
SVA_RS18885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SVA_RS18890	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SVA_RS18895	COG0513	Belongs to the DEAD box helicase family
SVA_RS18905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SVA_RS18915	COG0254	rRNA binding
SVA_RS18920	COG1525	nuclease
SVA_RS18930	COG0281	malic enzyme
SVA_RS18935	COG0039	L-malate dehydrogenase activity
SVA_RS18950	COG2067	long-chain fatty acid transport protein
SVA_RS18955	COG1250	3-hydroxyacyl-CoA dehydrogenase
SVA_RS18955	COG1024	Enoyl-CoA hydratase
SVA_RS18960	COG0183	Belongs to the thiolase family
SVA_RS18965	COG1960	acyl-CoA dehydrogenase activity
SVA_RS18970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SVA_RS18975	COG2204	response regulator
SVA_RS18990	COG1773	rubredoxin
SVA_RS18995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SVA_RS19005	COG0352	thiamine-phosphate diphosphorylase activity
SVA_RS19010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SVA_RS19030	COG1611	Belongs to the LOG family
SVA_RS19045	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SVA_RS19065	COG0210	DNA helicase
SVA_RS19110	COG0492	ferredoxin-NADP+ reductase activity
SVA_RS19115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SVA_RS19120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SVA_RS19125	COG1047	Peptidyl-prolyl cis-trans
SVA_RS19130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SVA_RS19135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SVA_RS19140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SVA_RS19145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SVA_RS19150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SVA_RS19155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SVA_RS19165	COG0356	it plays a direct role in the translocation of protons across the membrane
SVA_RS19175	COG0517	IMP dehydrogenase activity
SVA_RS19175	COG0617	tRNA 3'-terminal CCA addition
SVA_RS19175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SVA_RS19190	COG1475	DNA binding
SVA_RS19195	COG1192	Involved in chromosome partitioning
SVA_RS19200	COG0357	Ribosomal RNA small subunit methyltransferase G
SVA_RS19205	COG0445	tRNA wobble uridine modification
SVA_RS19210	COG0714	Associated with various cellular activities
SVA_RS19225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SVA_RS19230	COG0706	membrane insertase activity
SVA_RS19235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SVA_RS19240	COG0594	ribonuclease P activity
SVA_RS19245	COG0230	Belongs to the bacterial ribosomal protein bL34 family