locus-tag	class	description
SYO3AOP1_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SYO3AOP1_RS00015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYO3AOP1_RS00020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SYO3AOP1_RS00025	COG0352	thiamine-phosphate diphosphorylase activity
SYO3AOP1_RS00030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYO3AOP1_RS00045	COG0312	modulator of DNA gyrase
SYO3AOP1_RS00055	COG5001	Diguanylate cyclase
SYO3AOP1_RS00055	COG3300	MHYT domain
SYO3AOP1_RS00065	COG1256	bacterial-type flagellum assembly
SYO3AOP1_RS00065	COG4786	Flagellar basal body rod
SYO3AOP1_RS00070	COG1940	carbohydrate kinase activity
SYO3AOP1_RS00085	COG0598	Magnesium transport protein CorA
SYO3AOP1_RS00095	COG1663	tetraacyldisaccharide 4'-kinase activity
SYO3AOP1_RS00100	COG1234	tRNA 3'-trailer cleavage
SYO3AOP1_RS00115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SYO3AOP1_RS00130	COG0402	S-adenosylhomocysteine deaminase activity
SYO3AOP1_RS00140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYO3AOP1_RS00155	COG3383	formate dehydrogenase (NAD+) activity
SYO3AOP1_RS00160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SYO3AOP1_RS00165	COG0802	atpase or kinase
SYO3AOP1_RS00175	COG0497	DNA recombination
SYO3AOP1_RS00180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SYO3AOP1_RS00185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SYO3AOP1_RS00190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYO3AOP1_RS00195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYO3AOP1_RS00205	COG3108	Peptidase M15
SYO3AOP1_RS00235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SYO3AOP1_RS00240	COG0004	ammonium transporteR
SYO3AOP1_RS00245	COG0347	Belongs to the P(II) protein family
SYO3AOP1_RS00250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYO3AOP1_RS00255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYO3AOP1_RS00255	COG1648	precorrin-2 dehydrogenase activity
SYO3AOP1_RS00265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYO3AOP1_RS00275	COG0243	molybdopterin cofactor binding
SYO3AOP1_RS00280	COG1116	anion transmembrane transporter activity
SYO3AOP1_RS00285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYO3AOP1_RS00290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SYO3AOP1_RS00305	COG1160	GTP binding
SYO3AOP1_RS00315	COG3328	transposase activity
SYO3AOP1_RS00335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYO3AOP1_RS00340	COG0521	Mo-molybdopterin cofactor biosynthetic process
SYO3AOP1_RS00345	COG0316	Belongs to the HesB IscA family
SYO3AOP1_RS00350	COG0616	signal peptide processing
SYO3AOP1_RS00355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SYO3AOP1_RS00385	COG0105	UTP biosynthetic process
SYO3AOP1_RS00420	COG0589	response to stress
SYO3AOP1_RS00425	COG2855	membrane
SYO3AOP1_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SYO3AOP1_RS00445	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SYO3AOP1_RS00450	COG0322	excinuclease ABC activity
SYO3AOP1_RS00455	COG3328	transposase activity
SYO3AOP1_RS00465	COG0084	hydrolase, TatD family'
SYO3AOP1_RS00470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYO3AOP1_RS00480	COG0037	tRNA processing
SYO3AOP1_RS00490	COG0268	Binds directly to 16S ribosomal RNA
SYO3AOP1_RS00495	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SYO3AOP1_RS00525	COG1515	deoxyribonuclease V activity
SYO3AOP1_RS00535	COG0772	Belongs to the SEDS family
SYO3AOP1_RS00540	COG0768	penicillin binding
SYO3AOP1_RS00555	COG1077	Cell shape determining protein MreB Mrl
SYO3AOP1_RS00560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SYO3AOP1_RS00570	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SYO3AOP1_RS00575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SYO3AOP1_RS00580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYO3AOP1_RS00585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYO3AOP1_RS00590	COG0406	alpha-ribazole phosphatase activity
SYO3AOP1_RS00595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SYO3AOP1_RS00600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYO3AOP1_RS00605	COG0071	Belongs to the small heat shock protein (HSP20) family
SYO3AOP1_RS00610	COG0336	Belongs to the RNA methyltransferase TrmD family
SYO3AOP1_RS00630	COG4145	pantothenate transmembrane transporter activity
SYO3AOP1_RS00635	COG0165	Argininosuccinate lyase
SYO3AOP1_RS00645	COG1546	Belongs to the CinA family
SYO3AOP1_RS00645	COG1058	Belongs to the CinA family
SYO3AOP1_RS00665	COG5002	protein histidine kinase activity
SYO3AOP1_RS00680	COG3328	transposase activity
SYO3AOP1_RS00685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYO3AOP1_RS00695	COG0433	COG0433 Predicted ATPase
SYO3AOP1_RS00715	COG0511	ligase activity, forming carbon-carbon bonds
SYO3AOP1_RS00715	COG5016	pyruvate
SYO3AOP1_RS00720	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYO3AOP1_RS00725	COG0642	Histidine kinase
SYO3AOP1_RS00730	COG0745	RESPONSE REGULATOR receiver
SYO3AOP1_RS00745	COG0318	PFAM AMP-dependent synthetase and ligase
SYO3AOP1_RS00750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SYO3AOP1_RS00755	COG1862	Preprotein translocase
SYO3AOP1_RS00760	COG1715	Restriction endonuclease
SYO3AOP1_RS00770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYO3AOP1_RS00775	COG1054	Belongs to the UPF0176 family
SYO3AOP1_RS00795	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SYO3AOP1_RS00800	COG0612	Peptidase, M16
SYO3AOP1_RS00835	COG0167	dihydroorotate dehydrogenase activity
SYO3AOP1_RS00840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYO3AOP1_RS00845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYO3AOP1_RS00850	COG2890	protein-(glutamine-N5) methyltransferase activity
SYO3AOP1_RS00855	COG2860	membrane
SYO3AOP1_RS00860	COG1489	DNA binding
SYO3AOP1_RS00865	COG2255	four-way junction helicase activity
SYO3AOP1_RS00875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SYO3AOP1_RS00880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SYO3AOP1_RS00885	COG1196	nuclear chromosome segregation
SYO3AOP1_RS00895	COG0564	pseudouridine synthase activity
SYO3AOP1_RS00905	COG0307	riboflavin synthase, alpha
SYO3AOP1_RS00910	COG1137	ATPase activity
SYO3AOP1_RS00915	COG1466	dna polymerase III delta subunit
SYO3AOP1_RS00925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SYO3AOP1_RS00930	COG0742	ribosomal rna small subunit methyltransferase
SYO3AOP1_RS00940	COG0785	Cytochrome C biogenesis protein
SYO3AOP1_RS00950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SYO3AOP1_RS00955	COG1028	Short-chain dehydrogenase reductase Sdr
SYO3AOP1_RS00960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYO3AOP1_RS00965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SYO3AOP1_RS00970	COG0335	large ribosomal subunit rRNA binding
SYO3AOP1_RS00975	COG3300	MHYT domain
SYO3AOP1_RS00975	COG5001	Diguanylate cyclase
SYO3AOP1_RS00990	COG0653	protein targeting
SYO3AOP1_RS00995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SYO3AOP1_RS01005	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SYO3AOP1_RS01015	COG2204	response regulator
SYO3AOP1_RS01025	COG0512	Glutamine amidotransferase of anthranilate synthase
SYO3AOP1_RS01030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SYO3AOP1_RS01035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SYO3AOP1_RS01040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYO3AOP1_RS01045	COG3267	Type II secretory pathway component ExeA
SYO3AOP1_RS01045	COG3409	Peptidoglycan-binding domain 1 protein
SYO3AOP1_RS01060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SYO3AOP1_RS01075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SYO3AOP1_RS01080	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SYO3AOP1_RS01085	COG1217	gtp-binding protein TYPA
SYO3AOP1_RS01090	COG0606	chelatase, subunit chli
SYO3AOP1_RS01130	COG0606	chelatase, subunit chli
SYO3AOP1_RS01150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYO3AOP1_RS01155	COG1213	nucleotidyl transferase
SYO3AOP1_RS01155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SYO3AOP1_RS01160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SYO3AOP1_RS01170	COG0440	acetolactate synthase activity
SYO3AOP1_RS01180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SYO3AOP1_RS01190	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SYO3AOP1_RS01205	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SYO3AOP1_RS01210	COG3706	GGDEF domain
SYO3AOP1_RS01215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SYO3AOP1_RS01225	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SYO3AOP1_RS01230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SYO3AOP1_RS01235	COG0210	DNA helicase
SYO3AOP1_RS01245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYO3AOP1_RS01250	COG0495	leucyl-tRNA aminoacylation
SYO3AOP1_RS01260	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
SYO3AOP1_RS01265	COG0328	RNA-DNA hybrid ribonuclease activity
SYO3AOP1_RS01270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SYO3AOP1_RS01275	COG1053	succinate dehydrogenase
SYO3AOP1_RS01305	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SYO3AOP1_RS01320	COG1872	DUF167
SYO3AOP1_RS01325	COG1260	myo-inositol-1-phosphate synthase
SYO3AOP1_RS01330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SYO3AOP1_RS01335	COG1242	4 iron, 4 sulfur cluster binding
SYO3AOP1_RS01345	COG0203	ribosomal protein L17
SYO3AOP1_RS01350	COG0202	RNA polymerase activity
SYO3AOP1_RS01355	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SYO3AOP1_RS01365	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SYO3AOP1_RS01370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SYO3AOP1_RS01375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SYO3AOP1_RS01380	COG0024	Methionine aminopeptidase
SYO3AOP1_RS01385	COG0563	adenylate kinase activity
SYO3AOP1_RS01390	COG0201	protein transport
SYO3AOP1_RS01395	COG0200	Binds to the 23S rRNA
SYO3AOP1_RS01400	COG1841	ribosomal large subunit assembly
SYO3AOP1_RS01405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SYO3AOP1_RS01415	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SYO3AOP1_RS01420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SYO3AOP1_RS01425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SYO3AOP1_RS01430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SYO3AOP1_RS01435	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SYO3AOP1_RS01440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SYO3AOP1_RS01445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SYO3AOP1_RS01450	COG0255	Belongs to the universal ribosomal protein uL29 family
SYO3AOP1_RS01455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SYO3AOP1_RS01460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SYO3AOP1_RS01465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SYO3AOP1_RS01470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SYO3AOP1_RS01475	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SYO3AOP1_RS01480	COG0089	rRNA binding
SYO3AOP1_RS01485	COG0088	Forms part of the polypeptide exit tunnel
SYO3AOP1_RS01490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SYO3AOP1_RS01495	COG0051	transcription antitermination factor activity, RNA binding
SYO3AOP1_RS01505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYO3AOP1_RS01510	COG0049	tRNA binding
SYO3AOP1_RS01515	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SYO3AOP1_RS01520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYO3AOP1_RS01525	COG0085	RNA polymerase activity
SYO3AOP1_RS01530	COG0222	ribosome binding
SYO3AOP1_RS01535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SYO3AOP1_RS01540	COG0081	regulation of translation
SYO3AOP1_RS01545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SYO3AOP1_RS01550	COG0250	Participates in transcription elongation, termination and antitermination
SYO3AOP1_RS01565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SYO3AOP1_RS01595	COG1355	regulation of microtubule-based process
SYO3AOP1_RS01600	COG2078	PFAM AMMECR1 domain protein
SYO3AOP1_RS01600	COG3885	ferrous iron binding
SYO3AOP1_RS01605	COG1216	Glycosyl transferase, family 2
SYO3AOP1_RS01620	COG1136	(ABC) transporter
SYO3AOP1_RS01630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SYO3AOP1_RS01635	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYO3AOP1_RS01645	COG0156	8-amino-7-oxononanoate synthase activity
SYO3AOP1_RS01650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SYO3AOP1_RS01655	COG0159	tryptophan synthase activity
SYO3AOP1_RS01665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SYO3AOP1_RS01670	COG0740	serine-type endopeptidase activity
SYO3AOP1_RS01675	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYO3AOP1_RS01680	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SYO3AOP1_RS01690	COG0358	DNA primase activity
SYO3AOP1_RS01695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYO3AOP1_RS01710	COG0745	RESPONSE REGULATOR receiver
SYO3AOP1_RS01720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SYO3AOP1_RS01725	COG0135	phosphoribosylanthranilate isomerase activity
SYO3AOP1_RS01730	COG3958	Transketolase
SYO3AOP1_RS01735	COG3959	Transketolase, thiamine diphosphate binding domain
SYO3AOP1_RS01755	COG0066	3-isopropylmalate dehydratase activity
SYO3AOP1_RS01780	COG0180	Tryptophanyl-tRNA synthetase
SYO3AOP1_RS01825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SYO3AOP1_RS01835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SYO3AOP1_RS01850	COG0642	Histidine kinase
SYO3AOP1_RS01865	COG1309	transcriptional regulator
SYO3AOP1_RS01870	COG1490	D-aminoacyl-tRNA deacylase activity
SYO3AOP1_RS01880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SYO3AOP1_RS01885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYO3AOP1_RS01890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SYO3AOP1_RS01905	COG0196	riboflavin kinase activity
SYO3AOP1_RS01915	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SYO3AOP1_RS01925	COG1278	Cold shock
SYO3AOP1_RS01930	COG1278	Cold shock
SYO3AOP1_RS01935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYO3AOP1_RS01940	COG0352	thiamine-phosphate diphosphorylase activity
SYO3AOP1_RS01950	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYO3AOP1_RS01955	COG3118	belongs to the thioredoxin family
SYO3AOP1_RS01965	COG2048	Heterodisulfide reductase, subunit B
SYO3AOP1_RS01970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SYO3AOP1_RS01980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SYO3AOP1_RS01985	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SYO3AOP1_RS01990	COG1127	ABC transporter
SYO3AOP1_RS02000	COG3328	transposase activity
SYO3AOP1_RS02010	COG0552	protein localization to endoplasmic reticulum
SYO3AOP1_RS02010	COG0457	Tetratricopeptide repeat
SYO3AOP1_RS02015	COG0469	pyruvate kinase activity
SYO3AOP1_RS02020	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYO3AOP1_RS02030	COG1253	flavin adenine dinucleotide binding
SYO3AOP1_RS02035	COG4608	Belongs to the ABC transporter superfamily
SYO3AOP1_RS02045	COG0436	Aminotransferase
SYO3AOP1_RS02050	COG0859	PFAM glycosyl transferase family 9
SYO3AOP1_RS02065	COG1465	3-dehydroquinate synthase
SYO3AOP1_RS02070	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SYO3AOP1_RS02075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYO3AOP1_RS02090	COG0205	6-phosphofructokinase activity
SYO3AOP1_RS02105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SYO3AOP1_RS02115	COG1774	PSP1 C-terminal conserved region
SYO3AOP1_RS02120	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SYO3AOP1_RS02120	COG0517	IMP dehydrogenase activity
SYO3AOP1_RS02125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SYO3AOP1_RS02140	COG0477	Major facilitator Superfamily
SYO3AOP1_RS02150	COG0142	geranyltranstransferase activity
SYO3AOP1_RS02155	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SYO3AOP1_RS02160	COG1388	LysM domain
SYO3AOP1_RS02160	COG0741	lytic transglycosylase activity
SYO3AOP1_RS02165	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SYO3AOP1_RS02180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SYO3AOP1_RS02185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SYO3AOP1_RS02190	COG0772	Belongs to the SEDS family
SYO3AOP1_RS02195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYO3AOP1_RS02200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SYO3AOP1_RS02205	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYO3AOP1_RS02220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SYO3AOP1_RS02230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SYO3AOP1_RS02245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SYO3AOP1_RS02250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SYO3AOP1_RS02265	COG0450	alkyl hydroperoxide reductase
SYO3AOP1_RS02275	COG0477	Major facilitator Superfamily
SYO3AOP1_RS02285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYO3AOP1_RS02285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SYO3AOP1_RS02290	COG1372	Participates in initiation and elongation during chromosome replication
SYO3AOP1_RS02290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SYO3AOP1_RS02295	COG0243	molybdopterin cofactor binding
SYO3AOP1_RS02300	COG0437	4 iron, 4 sulfur cluster binding
SYO3AOP1_RS02305	COG0348	domain, Protein
SYO3AOP1_RS02310	COG3043	anaerobic respiration
SYO3AOP1_RS02360	COG1131	(ABC) transporter
SYO3AOP1_RS02370	COG1522	sequence-specific DNA binding
SYO3AOP1_RS02375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SYO3AOP1_RS02375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYO3AOP1_RS02385	COG0602	queuosine metabolic process
SYO3AOP1_RS02390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYO3AOP1_RS02400	COG0535	radical SAM domain protein
SYO3AOP1_RS02410	COG2010	Cytochrome c
SYO3AOP1_RS02415	COG2010	Cytochrome c
SYO3AOP1_RS02425	COG1648	precorrin-2 dehydrogenase activity
SYO3AOP1_RS02425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYO3AOP1_RS02430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SYO3AOP1_RS02435	COG2151	metal-sulfur cluster biosynthetic enzyme
SYO3AOP1_RS02465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SYO3AOP1_RS02470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SYO3AOP1_RS02480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYO3AOP1_RS02485	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SYO3AOP1_RS02490	COG0583	DNA-binding transcription factor activity
SYO3AOP1_RS02495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SYO3AOP1_RS02530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SYO3AOP1_RS02535	COG0154	amidase activity
SYO3AOP1_RS02540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SYO3AOP1_RS02550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYO3AOP1_RS02565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SYO3AOP1_RS02575	COG1560	Kdo2-lipid A biosynthetic process
SYO3AOP1_RS02585	COG0471	metal ion transport
SYO3AOP1_RS02590	COG0460	homoserine dehydrogenase
SYO3AOP1_RS02595	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
SYO3AOP1_RS02600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SYO3AOP1_RS02600	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SYO3AOP1_RS02605	COG0590	tRNA wobble adenosine to inosine editing
SYO3AOP1_RS02655	COG0737	Belongs to the 5'-nucleotidase family
SYO3AOP1_RS02685	COG0446	pyridine nucleotide-disulphide oxidoreductase
SYO3AOP1_RS02695	COG0446	pyridine nucleotide-disulphide oxidoreductase
SYO3AOP1_RS02705	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SYO3AOP1_RS02710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SYO3AOP1_RS02720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SYO3AOP1_RS02725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SYO3AOP1_RS02730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SYO3AOP1_RS02755	COG0438	transferase activity, transferring glycosyl groups
SYO3AOP1_RS02780	COG0731	radical SAM domain protein
SYO3AOP1_RS02785	COG0493	'glutamate synthase
SYO3AOP1_RS02785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SYO3AOP1_RS02795	COG0540	Belongs to the ATCase OTCase family
SYO3AOP1_RS02815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYO3AOP1_RS02820	COG0792	nuclease activity
SYO3AOP1_RS02825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SYO3AOP1_RS02840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SYO3AOP1_RS02845	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SYO3AOP1_RS02850	COG2894	cell division
SYO3AOP1_RS02855	COG0850	regulation of cytokinetic process
SYO3AOP1_RS02860	COG0019	diaminopimelate decarboxylase activity
SYO3AOP1_RS02865	COG0151	Belongs to the GarS family
SYO3AOP1_RS02870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SYO3AOP1_RS02890	COG1543	Belongs to the glycosyl hydrolase 57 family
SYO3AOP1_RS02915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SYO3AOP1_RS02920	COG0484	heat shock protein binding
SYO3AOP1_RS02925	COG3411	Ferredoxin
SYO3AOP1_RS02930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYO3AOP1_RS02930	COG0758	DNA mediated transformation
SYO3AOP1_RS02940	COG0602	queuosine metabolic process
SYO3AOP1_RS02945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYO3AOP1_RS02955	COG0195	Participates in both transcription termination and antitermination
SYO3AOP1_RS02960	COG0779	Required for maturation of 30S ribosomal subunits
SYO3AOP1_RS02965	COG0233	cytoplasmic translational termination
SYO3AOP1_RS02970	COG0528	UMP kinase activity
SYO3AOP1_RS02975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SYO3AOP1_RS02980	COG0052	Belongs to the universal ribosomal protein uS2 family
SYO3AOP1_RS02990	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SYO3AOP1_RS03005	COG0303	'Molybdopterin
SYO3AOP1_RS03010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYO3AOP1_RS03020	COG0584	glycerophosphoryl diester phosphodiesterase
SYO3AOP1_RS03025	COG0459	protein refolding
SYO3AOP1_RS03030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYO3AOP1_RS03040	COG5002	protein histidine kinase activity
SYO3AOP1_RS03045	COG2204	response regulator
SYO3AOP1_RS03050	COG0534	Mate efflux family protein
SYO3AOP1_RS03055	COG2226	methyltransferase
SYO3AOP1_RS03060	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SYO3AOP1_RS03070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SYO3AOP1_RS03075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SYO3AOP1_RS03075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SYO3AOP1_RS03090	COG0018	arginyl-trna synthetase
SYO3AOP1_RS03105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYO3AOP1_RS03120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYO3AOP1_RS03140	COG2249	NAD(P)H dehydrogenase (quinone) activity
SYO3AOP1_RS03145	COG2027	D-alanyl-D-alanine carboxypeptidase
SYO3AOP1_RS03150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYO3AOP1_RS03160	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYO3AOP1_RS03165	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYO3AOP1_RS03170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYO3AOP1_RS03170	COG1144	Oxidoreductase
SYO3AOP1_RS03175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYO3AOP1_RS03180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYO3AOP1_RS03185	COG1013	pyruvate-flavodoxin oxidoreductase activity
SYO3AOP1_RS03190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SYO3AOP1_RS03190	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYO3AOP1_RS03195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SYO3AOP1_RS03200	COG0045	succinate-CoA ligase (ADP-forming) activity
SYO3AOP1_RS03220	COG0039	L-malate dehydrogenase activity
SYO3AOP1_RS03235	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYO3AOP1_RS03240	COG0649	NAD binding
SYO3AOP1_RS03240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYO3AOP1_RS03250	COG2003	Belongs to the UPF0758 family
SYO3AOP1_RS03260	COG0587	DNA-directed DNA polymerase activity
SYO3AOP1_RS03270	COG3328	transposase activity
SYO3AOP1_RS03280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SYO3AOP1_RS03285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SYO3AOP1_RS03295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SYO3AOP1_RS03305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SYO3AOP1_RS03325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SYO3AOP1_RS03330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SYO3AOP1_RS03335	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SYO3AOP1_RS03340	COG1981	membrane
SYO3AOP1_RS03345	COG0157	Belongs to the NadC ModD family
SYO3AOP1_RS03350	COG0473	3-isopropylmalate dehydrogenase activity
SYO3AOP1_RS03365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SYO3AOP1_RS03470	COG1518	maintenance of DNA repeat elements
SYO3AOP1_RS03475	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SYO3AOP1_RS03480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYO3AOP1_RS03485	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYO3AOP1_RS03490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SYO3AOP1_RS03495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SYO3AOP1_RS03500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SYO3AOP1_RS03505	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYO3AOP1_RS03525	COG0463	Glycosyl transferase, family 2
SYO3AOP1_RS03530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SYO3AOP1_RS03540	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SYO3AOP1_RS03545	COG0217	transcriptional regulatory protein
SYO3AOP1_RS03550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SYO3AOP1_RS03555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SYO3AOP1_RS03560	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SYO3AOP1_RS03570	COG0181	hydroxymethylbilane synthase activity
SYO3AOP1_RS03580	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
SYO3AOP1_RS03585	COG0357	Ribosomal RNA small subunit methyltransferase G
SYO3AOP1_RS03595	COG0517	IMP dehydrogenase activity
SYO3AOP1_RS03595	COG0516	GMP reductase activity
SYO3AOP1_RS03600	COG1881	PFAM PEBP family protein
SYO3AOP1_RS03610	COG3260	NADH ubiquinone oxidoreductase 20
SYO3AOP1_RS03615	COG0649	NAD binding
SYO3AOP1_RS03620	COG0651	ATP synthesis coupled electron transport
SYO3AOP1_RS03635	COG0651	ATP synthesis coupled electron transport
SYO3AOP1_RS03645	COG0351	phosphomethylpyrimidine kinase
SYO3AOP1_RS03665	COG1187	pseudouridine synthase activity
SYO3AOP1_RS03670	COG2217	Heavy metal translocating P-type atpase
SYO3AOP1_RS03685	COG3279	Response regulator of the LytR AlgR family
SYO3AOP1_RS03710	COG0562	UDP-galactopyranose mutase
SYO3AOP1_RS03715	COG3275	phosphorelay sensor kinase activity
SYO3AOP1_RS03790	COG2200	EAL domain
SYO3AOP1_RS03810	COG0811	peptide transport
SYO3AOP1_RS03815	COG0848	biopolymer transport protein
SYO3AOP1_RS03820	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SYO3AOP1_RS03825	COG3540	Alkaline phosphatase
SYO3AOP1_RS03840	COG0573	inorganic phosphate transmembrane transporter activity
SYO3AOP1_RS03845	COG0581	inorganic phosphate transmembrane transporter activity
SYO3AOP1_RS03850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYO3AOP1_RS03855	COG0704	Plays a role in the regulation of phosphate uptake
SYO3AOP1_RS03860	COG5002	protein histidine kinase activity
SYO3AOP1_RS03865	COG2067	long-chain fatty acid transport protein
SYO3AOP1_RS03880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SYO3AOP1_RS03880	COG2022	thiamine diphosphate biosynthetic process
SYO3AOP1_RS03885	COG1234	tRNA 3'-trailer cleavage
SYO3AOP1_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
SYO3AOP1_RS03895	COG0481	GTPase activity
SYO3AOP1_RS03900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYO3AOP1_RS03905	COG0133	tryptophan synthase activity
SYO3AOP1_RS03910	COG3634	alkyl hydroperoxide reductase activity
SYO3AOP1_RS03920	COG0730	response to heat
SYO3AOP1_RS03925	COG0495	leucyl-tRNA aminoacylation
SYO3AOP1_RS03935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SYO3AOP1_RS03945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SYO3AOP1_RS03950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SYO3AOP1_RS03955	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
SYO3AOP1_RS03990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SYO3AOP1_RS04005	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SYO3AOP1_RS04010	COG0004	ammonium transporteR
SYO3AOP1_RS04040	COG0432	Pfam Uncharacterised protein family UPF0047
SYO3AOP1_RS04060	COG1331	Highly conserved protein containing a thioredoxin domain
SYO3AOP1_RS04065	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SYO3AOP1_RS04065	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SYO3AOP1_RS04095	COG3039	Transposase
SYO3AOP1_RS04100	COG1185	polyribonucleotide nucleotidyltransferase activity
SYO3AOP1_RS04105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SYO3AOP1_RS04120	COG2257	FlhB HrpN YscU SpaS Family
SYO3AOP1_RS04125	COG2171	N-acyltransferase activity
SYO3AOP1_RS04130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYO3AOP1_RS04135	COG1509	lysine 2,3-aminomutase activity
SYO3AOP1_RS04140	COG1692	metallophosphoesterase
SYO3AOP1_RS04150	COG0793	Belongs to the peptidase S41A family
SYO3AOP1_RS04155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SYO3AOP1_RS04160	COG1605	Chorismate mutase
SYO3AOP1_RS04160	COG0077	Prephenate dehydratase
SYO3AOP1_RS04165	COG0483	inositol monophosphate 1-phosphatase activity
SYO3AOP1_RS04170	COG0126	phosphoglycerate kinase activity
SYO3AOP1_RS04180	COG0517	IMP dehydrogenase activity
SYO3AOP1_RS04180	COG0516	GMP reductase activity
SYO3AOP1_RS04185	COG0133	tryptophan synthase activity
SYO3AOP1_RS04195	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SYO3AOP1_RS04205	COG0248	Ppx GppA phosphatase
SYO3AOP1_RS04210	COG0556	nucleotide-excision repair
SYO3AOP1_RS04215	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SYO3AOP1_RS04230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SYO3AOP1_RS04240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYO3AOP1_RS04245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SYO3AOP1_RS04250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYO3AOP1_RS04265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYO3AOP1_RS04270	COG0416	fatty acid biosynthetic process
SYO3AOP1_RS04275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SYO3AOP1_RS04285	COG0717	Belongs to the dCTP deaminase family
SYO3AOP1_RS04290	COG0791	NLP P60 protein
SYO3AOP1_RS04290	COG1388	LysM domain
SYO3AOP1_RS04295	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SYO3AOP1_RS04300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SYO3AOP1_RS04310	COG4591	ABC-type transport system involved in lipoprotein release permease component
SYO3AOP1_RS04315	COG1136	(ABC) transporter
SYO3AOP1_RS04320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SYO3AOP1_RS04325	COG1360	Flagellar Motor Protein
SYO3AOP1_RS04340	COG0746	molybdenum cofactor guanylyltransferase activity
SYO3AOP1_RS04345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYO3AOP1_RS04350	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SYO3AOP1_RS04355	COG0142	geranyltranstransferase activity
SYO3AOP1_RS04375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SYO3AOP1_RS04400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SYO3AOP1_RS04410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SYO3AOP1_RS04415	COG2022	thiamine diphosphate biosynthetic process
SYO3AOP1_RS04435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SYO3AOP1_RS04445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SYO3AOP1_RS04455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SYO3AOP1_RS04460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SYO3AOP1_RS04470	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYO3AOP1_RS04475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SYO3AOP1_RS04500	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SYO3AOP1_RS04520	COG1758	RNA polymerase activity
SYO3AOP1_RS04530	COG1007	ATP synthesis coupled electron transport
SYO3AOP1_RS04545	COG0713	ATP synthesis coupled electron transport
SYO3AOP1_RS04550	COG0839	Belongs to the complex I subunit 6 family
SYO3AOP1_RS04555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYO3AOP1_RS04560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SYO3AOP1_RS04565	COG0649	NAD binding
SYO3AOP1_RS04565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYO3AOP1_RS04570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYO3AOP1_RS04575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SYO3AOP1_RS04590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYO3AOP1_RS04600	COG0443	Heat shock 70 kDa protein
SYO3AOP1_RS04605	COG0501	Belongs to the peptidase M48B family
SYO3AOP1_RS04610	COG2210	Belongs to the sulfur carrier protein TusA family
SYO3AOP1_RS04615	COG0750	zinc metalloprotease
SYO3AOP1_RS04620	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SYO3AOP1_RS04625	COG0242	peptide deformylase activity
SYO3AOP1_RS04635	COG0509	glycine decarboxylation via glycine cleavage system
SYO3AOP1_RS04640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYO3AOP1_RS04675	COG1730	sister chromatid segregation
SYO3AOP1_RS04680	COG2010	Cytochrome c
SYO3AOP1_RS04695	COG1477	protein flavinylation
SYO3AOP1_RS04705	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SYO3AOP1_RS04715	COG3328	transposase activity
SYO3AOP1_RS04725	COG1830	Aldolase
SYO3AOP1_RS04730	COG0628	permease
SYO3AOP1_RS04735	COG3956	TIGRFAM MazG family protein
SYO3AOP1_RS04745	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SYO3AOP1_RS04750	COG0840	transmembrane signaling receptor activity
SYO3AOP1_RS04760	COG0840	transmembrane signaling receptor activity
SYO3AOP1_RS04770	COG0784	Response regulator, receiver
SYO3AOP1_RS04770	COG0835	chemotaxis
SYO3AOP1_RS04780	COG0643	Histidine kinase
SYO3AOP1_RS04780	COG0784	Response regulator, receiver
SYO3AOP1_RS04780	COG2198	Histidine kinase
SYO3AOP1_RS04785	COG0835	chemotaxis
SYO3AOP1_RS04785	COG0784	Response regulator, receiver
SYO3AOP1_RS04790	COG0484	heat shock protein binding
SYO3AOP1_RS04800	COG0745	RESPONSE REGULATOR receiver
SYO3AOP1_RS04840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYO3AOP1_RS04855	COG0640	Transcriptional regulator
SYO3AOP1_RS04860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SYO3AOP1_RS04905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SYO3AOP1_RS04915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYO3AOP1_RS04915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYO3AOP1_RS04920	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SYO3AOP1_RS04945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SYO3AOP1_RS04950	COG0457	Tetratricopeptide repeat
SYO3AOP1_RS04955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYO3AOP1_RS04965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SYO3AOP1_RS04995	COG0419	ATPase involved in DNA repair
SYO3AOP1_RS05005	COG0592	DNA-directed DNA polymerase activity
SYO3AOP1_RS05010	COG0187	DNA topoisomerase II activity
SYO3AOP1_RS05015	COG1376	ErfK ybiS ycfS ynhG family protein
SYO3AOP1_RS05015	COG1388	LysM domain
SYO3AOP1_RS05025	COG0728	peptidoglycan biosynthetic process
SYO3AOP1_RS05045	COG0356	it plays a direct role in the translocation of protons across the membrane
SYO3AOP1_RS05055	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYO3AOP1_RS05070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SYO3AOP1_RS05075	COG0706	membrane insertase activity
SYO3AOP1_RS05080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYO3AOP1_RS05085	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SYO3AOP1_RS05095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYO3AOP1_RS05105	COG0513	Belongs to the DEAD box helicase family
SYO3AOP1_RS05115	COG0444	Belongs to the ABC transporter superfamily
SYO3AOP1_RS05120	COG1530	ribonuclease E activity
SYO3AOP1_RS05130	COG0799	negative regulation of ribosome biogenesis
SYO3AOP1_RS05135	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SYO3AOP1_RS05140	COG0564	pseudouridine synthase activity
SYO3AOP1_RS05155	COG0457	Tetratricopeptide repeat
SYO3AOP1_RS05155	COG0463	Glycosyl transferase, family 2
SYO3AOP1_RS05160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SYO3AOP1_RS05165	COG1334	flagellar protein FlaG
SYO3AOP1_RS05185	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SYO3AOP1_RS05190	COG1449	Belongs to the glycosyl hydrolase 57 family
SYO3AOP1_RS05205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYO3AOP1_RS05210	COG0436	Aminotransferase
SYO3AOP1_RS05235	COG1216	Glycosyl transferase, family 2
SYO3AOP1_RS05300	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SYO3AOP1_RS05310	COG1993	acr, cog1993
SYO3AOP1_RS05315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SYO3AOP1_RS05320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYO3AOP1_RS05325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SYO3AOP1_RS05330	COG0698	ribose 5-phosphate isomerase
SYO3AOP1_RS05335	COG1376	ErfK ybiS ycfS ynhG family protein
SYO3AOP1_RS05335	COG1388	LysM domain
SYO3AOP1_RS05340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SYO3AOP1_RS05345	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SYO3AOP1_RS05360	COG0107	imidazoleglycerol-phosphate synthase activity
SYO3AOP1_RS05365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYO3AOP1_RS05375	COG4752	Belongs to the RNA methyltransferase TrmD family
SYO3AOP1_RS05380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYO3AOP1_RS05385	COG1067	ATP-dependent peptidase activity
SYO3AOP1_RS05390	COG5000	phosphorelay sensor kinase activity
SYO3AOP1_RS05395	COG0372	Belongs to the citrate synthase family
SYO3AOP1_RS05410	COG0148	phosphopyruvate hydratase activity
SYO3AOP1_RS05415	COG0439	Biotin carboxylase
SYO3AOP1_RS05420	COG0527	aspartate kinase activity
SYO3AOP1_RS05425	COG0617	tRNA 3'-terminal CCA addition
SYO3AOP1_RS05435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYO3AOP1_RS05440	COG0302	gtp cyclohydrolase
SYO3AOP1_RS05445	COG1832	CoA-binding protein
SYO3AOP1_RS05450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYO3AOP1_RS05460	COG0752	glycyl-tRNA synthetase alpha subunit
SYO3AOP1_RS05465	COG0751	glycine-tRNA ligase activity
SYO3AOP1_RS05470	COG0574	Belongs to the PEP-utilizing enzyme family
SYO3AOP1_RS05470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SYO3AOP1_RS05475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SYO3AOP1_RS05485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYO3AOP1_RS05485	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYO3AOP1_RS05505	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SYO3AOP1_RS05510	COG0511	ligase activity, forming carbon-carbon bonds
SYO3AOP1_RS05515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYO3AOP1_RS05520	COG0083	homoserine kinase activity
SYO3AOP1_RS05525	COG4641	Protein conserved in bacteria
SYO3AOP1_RS05530	COG0138	bifunctional purine biosynthesis protein purh
SYO3AOP1_RS05535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SYO3AOP1_RS05560	COG0174	glutamine synthetase
SYO3AOP1_RS05565	COG0347	Belongs to the P(II) protein family
SYO3AOP1_RS05570	COG1012	belongs to the aldehyde dehydrogenase family
SYO3AOP1_RS05575	COG1294	oxidase, subunit
SYO3AOP1_RS05580	COG1271	oxidase subunit
SYO3AOP1_RS05605	COG1611	Belongs to the LOG family
SYO3AOP1_RS05610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SYO3AOP1_RS05615	COG0735	belongs to the Fur family
SYO3AOP1_RS05620	COG1573	uracil-dna glycosylase
SYO3AOP1_RS05630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SYO3AOP1_RS05635	COG0776	regulation of translation
SYO3AOP1_RS05640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SYO3AOP1_RS05655	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SYO3AOP1_RS05660	COG0504	CTP synthase activity
SYO3AOP1_RS05665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYO3AOP1_RS05670	COG0557	exoribonuclease II activity
SYO3AOP1_RS05680	COG0314	molybdopterin synthase activity
SYO3AOP1_RS05685	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SYO3AOP1_RS05690	COG0006	proline dipeptidase activity
SYO3AOP1_RS05700	COG0693	protein deglycase activity
SYO3AOP1_RS05705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYO3AOP1_RS05710	COG0671	phosphoesterase, PA-phosphatase related
SYO3AOP1_RS05720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SYO3AOP1_RS05730	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SYO3AOP1_RS05735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYO3AOP1_RS05755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYO3AOP1_RS05760	COG1121	(ABC) transporter
SYO3AOP1_RS05775	COG1414	Transcriptional regulator
SYO3AOP1_RS05785	COG0070	glutamate synthase
SYO3AOP1_RS05785	COG0069	glutamate synthase activity
SYO3AOP1_RS05785	COG0067	glutamate synthase
SYO3AOP1_RS05790	COG1525	nuclease
SYO3AOP1_RS05795	COG0681	Belongs to the peptidase S26 family
SYO3AOP1_RS05805	COG0237	dephospho-CoA kinase activity
SYO3AOP1_RS05810	COG3328	transposase activity
SYO3AOP1_RS05820	COG0668	transmembrane transport
SYO3AOP1_RS05825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SYO3AOP1_RS05865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SYO3AOP1_RS05880	COG1388	LysM domain
SYO3AOP1_RS05880	COG0741	lytic transglycosylase activity
SYO3AOP1_RS05930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SYO3AOP1_RS05945	COG0825	malonyl-CoA metabolic process
SYO3AOP1_RS05950	COG0588	phosphoglycerate mutase activity
SYO3AOP1_RS05955	COG0149	triose-phosphate isomerase activity
SYO3AOP1_RS05960	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SYO3AOP1_RS05965	COG3174	membrane
SYO3AOP1_RS05975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SYO3AOP1_RS05980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SYO3AOP1_RS05995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SYO3AOP1_RS06000	COG0446	pyridine nucleotide-disulphide oxidoreductase
SYO3AOP1_RS06005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYO3AOP1_RS06020	COG0228	four-way junction DNA binding
SYO3AOP1_RS06025	COG1837	Belongs to the UPF0109 family
SYO3AOP1_RS06035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYO3AOP1_RS06055	COG0243	molybdopterin cofactor binding
SYO3AOP1_RS06060	COG1140	nitrate reductase beta subunit
SYO3AOP1_RS06105	COG3328	transposase activity
SYO3AOP1_RS06125	COG1414	Transcriptional regulator
SYO3AOP1_RS06135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SYO3AOP1_RS06150	COG0163	prenyltransferase activity
SYO3AOP1_RS06175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SYO3AOP1_RS06180	COG0726	polysaccharide deacetylase
SYO3AOP1_RS06190	COG1132	(ABC) transporter
SYO3AOP1_RS06195	COG0438	transferase activity, transferring glycosyl groups
SYO3AOP1_RS06200	COG1216	Glycosyl transferase, family 2
SYO3AOP1_RS06210	COG0372	Belongs to the citrate synthase family
SYO3AOP1_RS06235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYO3AOP1_RS06255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SYO3AOP1_RS06260	COG0123	including yeast histone deacetylase and acetoin utilization protein
SYO3AOP1_RS06265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYO3AOP1_RS06270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SYO3AOP1_RS06280	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYO3AOP1_RS06285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SYO3AOP1_RS06290	COG1408	metallophosphoesterase
SYO3AOP1_RS06305	COG2200	EAL domain
SYO3AOP1_RS06305	COG2199	diguanylate cyclase activity
SYO3AOP1_RS06305	COG3287	FIST C domain
SYO3AOP1_RS06330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SYO3AOP1_RS06335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYO3AOP1_RS06360	COG2217	Heavy metal translocating P-type atpase
SYO3AOP1_RS06365	COG0826	peptidase U32
SYO3AOP1_RS06370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYO3AOP1_RS06375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SYO3AOP1_RS06375	COG0140	phosphoribosyl-ATP diphosphatase activity
SYO3AOP1_RS06385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SYO3AOP1_RS06390	COG0543	2 iron, 2 sulfur cluster binding
SYO3AOP1_RS06400	COG0720	synthase
SYO3AOP1_RS06405	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYO3AOP1_RS06410	COG0776	regulation of translation
SYO3AOP1_RS06420	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYO3AOP1_RS06425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYO3AOP1_RS06435	COG3158	transport of potassium into the cell
SYO3AOP1_RS06440	COG0505	Belongs to the CarA family
SYO3AOP1_RS06450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SYO3AOP1_RS06460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SYO3AOP1_RS06460	COG2755	lipolytic protein G-D-S-L family
SYO3AOP1_RS06465	COG1484	DNA-dependent DNA replication
SYO3AOP1_RS06470	COG0131	Imidazoleglycerol-phosphate dehydratase
SYO3AOP1_RS06475	COG1349	DNA-binding transcription factor activity
SYO3AOP1_RS06485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SYO3AOP1_RS06490	COG0343	queuine tRNA-ribosyltransferase activity
SYO3AOP1_RS06500	COG0124	histidyl-tRNA synthetase
SYO3AOP1_RS06510	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SYO3AOP1_RS06520	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SYO3AOP1_RS06535	COG0235	Class ii aldolase
SYO3AOP1_RS06540	COG0586	Pfam SNARE associated Golgi protein
SYO3AOP1_RS06555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SYO3AOP1_RS06560	COG0531	amino acid
SYO3AOP1_RS06565	COG0129	dihydroxy-acid dehydratase activity
SYO3AOP1_RS06570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SYO3AOP1_RS06580	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SYO3AOP1_RS06585	COG1276	copper resistance
SYO3AOP1_RS06590	COG1959	2 iron, 2 sulfur cluster binding
SYO3AOP1_RS06595	COG0321	lipoyl(octanoyl) transferase activity
SYO3AOP1_RS06605	COG0673	inositol 2-dehydrogenase activity
SYO3AOP1_RS06620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SYO3AOP1_RS06625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYO3AOP1_RS06645	COG2389	metal-binding protein
SYO3AOP1_RS06650	COG0517	IMP dehydrogenase activity
SYO3AOP1_RS06650	COG1994	Peptidase M50
SYO3AOP1_RS06675	COG0489	protein tyrosine kinase activity
SYO3AOP1_RS06680	COG1104	cysteine desulfurase activity
SYO3AOP1_RS06685	COG0822	iron-sulfur transferase activity
SYO3AOP1_RS06690	COG0482	sulfurtransferase activity
SYO3AOP1_RS06705	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SYO3AOP1_RS06710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SYO3AOP1_RS06720	COG1049	propionate catabolic process, 2-methylcitrate cycle
SYO3AOP1_RS06725	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SYO3AOP1_RS06730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYO3AOP1_RS06735	COG1923	regulation of RNA biosynthetic process
SYO3AOP1_RS06740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SYO3AOP1_RS06745	COG0537	adenosine 5'-monophosphoramidase activity
SYO3AOP1_RS06750	COG0425	Belongs to the sulfur carrier protein TusA family
SYO3AOP1_RS06760	COG0277	FAD linked oxidase domain protein
SYO3AOP1_RS06790	COG2151	metal-sulfur cluster biosynthetic enzyme
SYO3AOP1_RS06795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SYO3AOP1_RS06800	COG1968	undecaprenyl-diphosphatase activity
SYO3AOP1_RS06805	COG0134	indole-3-glycerol-phosphate synthase activity
SYO3AOP1_RS06810	COG1796	DNA polymerase
SYO3AOP1_RS06810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SYO3AOP1_RS06820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYO3AOP1_RS06845	COG0768	penicillin binding
SYO3AOP1_RS06855	COG0275	rRNA processing
SYO3AOP1_RS06875	COG0525	valine-tRNA ligase activity
SYO3AOP1_RS06880	COG0137	argininosuccinate synthase activity
SYO3AOP1_RS06895	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SYO3AOP1_RS06920	COG2217	Heavy metal translocating P-type atpase
SYO3AOP1_RS06950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SYO3AOP1_RS06970	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SYO3AOP1_RS06975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SYO3AOP1_RS06985	COG0287	Prephenate dehydrogenase
SYO3AOP1_RS06995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SYO3AOP1_RS07000	COG0505	Belongs to the CarA family
SYO3AOP1_RS07010	COG3328	transposase activity
SYO3AOP1_RS07025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SYO3AOP1_RS07030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SYO3AOP1_RS07035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYO3AOP1_RS07045	COG0848	biopolymer transport protein
SYO3AOP1_RS07050	COG0811	peptide transport
SYO3AOP1_RS07060	COG4772	TonB-dependent receptor
SYO3AOP1_RS07070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SYO3AOP1_RS07075	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYO3AOP1_RS07080	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SYO3AOP1_RS07090	COG2814	Major facilitator Superfamily
SYO3AOP1_RS07095	COG1566	PFAM secretion protein HlyD family protein
SYO3AOP1_RS07105	COG1309	transcriptional regulator
SYO3AOP1_RS07110	COG1979	alcohol dehydrogenase
SYO3AOP1_RS07130	COG0297	glycogen (starch) synthase activity
SYO3AOP1_RS07180	COG0297	glycogen (starch) synthase activity
SYO3AOP1_RS07220	COG2244	polysaccharide biosynthetic process
SYO3AOP1_RS07225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SYO3AOP1_RS07300	COG3328	transposase activity
SYO3AOP1_RS07340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYO3AOP1_RS07345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SYO3AOP1_RS07350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYO3AOP1_RS07355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SYO3AOP1_RS07360	COG2264	protein methyltransferase activity
SYO3AOP1_RS07365	COG0789	Transcriptional regulator
SYO3AOP1_RS07370	COG0484	heat shock protein binding
SYO3AOP1_RS07375	COG2176	DNA-directed DNA polymerase activity
SYO3AOP1_RS07380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SYO3AOP1_RS07395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYO3AOP1_RS07400	COG1205	dead DEAH box helicase
SYO3AOP1_RS07400	COG1111	helicase
SYO3AOP1_RS07410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SYO3AOP1_RS07415	COG0601	transmembrane transport
SYO3AOP1_RS07420	COG0436	Aminotransferase
SYO3AOP1_RS07430	COG1254	Belongs to the acylphosphatase family
SYO3AOP1_RS07435	COG1763	Mo-molybdopterin cofactor biosynthetic process
SYO3AOP1_RS07440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SYO3AOP1_RS07445	COG1496	oxidoreductase activity
SYO3AOP1_RS07450	COG0723	plastoquinol--plastocyanin reductase activity
SYO3AOP1_RS07455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SYO3AOP1_RS07465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SYO3AOP1_RS07470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYO3AOP1_RS07475	COG1160	GTP binding
SYO3AOP1_RS07485	COG0710	3-dehydroquinate dehydratase activity
SYO3AOP1_RS07505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYO3AOP1_RS07515	COG0390	transport system, permease component
SYO3AOP1_RS07520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SYO3AOP1_RS07520	COG1519	Transferase
SYO3AOP1_RS07530	COG1561	YicC-like family, N-terminal region
SYO3AOP1_RS07540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SYO3AOP1_RS07545	COG0735	belongs to the Fur family
SYO3AOP1_RS07555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYO3AOP1_RS07560	COG0805	protein transport
SYO3AOP1_RS07570	COG3706	GGDEF domain
SYO3AOP1_RS07575	COG0642	Histidine kinase
SYO3AOP1_RS07585	COG0745	RESPONSE REGULATOR receiver
SYO3AOP1_RS07590	COG0617	tRNA 3'-terminal CCA addition
SYO3AOP1_RS07590	COG0517	IMP dehydrogenase activity
SYO3AOP1_RS07590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SYO3AOP1_RS07600	COG0312	modulator of DNA gyrase
SYO3AOP1_RS07605	COG0824	Thioesterase
SYO3AOP1_RS07620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYO3AOP1_RS07635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYO3AOP1_RS07640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYO3AOP1_RS07645	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SYO3AOP1_RS07655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SYO3AOP1_RS07660	COG0113	porphobilinogen synthase activity
SYO3AOP1_RS07680	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYO3AOP1_RS07695	COG0124	histidyl-tRNA synthetase
SYO3AOP1_RS07700	COG0406	alpha-ribazole phosphatase activity
SYO3AOP1_RS07705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SYO3AOP1_RS07715	COG0037	tRNA processing
SYO3AOP1_RS07720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SYO3AOP1_RS07730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SYO3AOP1_RS07735	COG0285	dihydrofolate synthase activity
SYO3AOP1_RS07740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SYO3AOP1_RS07765	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SYO3AOP1_RS07770	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SYO3AOP1_RS07800	COG0714	Associated with various cellular activities
SYO3AOP1_RS07805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SYO3AOP1_RS07820	COG2814	Major facilitator Superfamily
SYO3AOP1_RS07825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SYO3AOP1_RS07870	COG3328	transposase activity
SYO3AOP1_RS07885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYO3AOP1_RS07890	COG3328	transposase activity
SYO3AOP1_RS07895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYO3AOP1_RS07905	COG3162	membrane
SYO3AOP1_RS07915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SYO3AOP1_RS07915	COG0517	IMP dehydrogenase activity
SYO3AOP1_RS07920	COG2176	DNA-directed DNA polymerase activity
SYO3AOP1_RS07930	COG0776	regulation of translation
SYO3AOP1_RS07940	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYO3AOP1_RS07945	COG3746	phosphate-selective porin O and P
SYO3AOP1_RS07955	COG0463	Glycosyl transferase, family 2
SYO3AOP1_RS07970	COG0490	domain, Protein
SYO3AOP1_RS07975	COG0475	glutathione-regulated potassium exporter activity
SYO3AOP1_RS07985	COG0475	glutathione-regulated potassium exporter activity
SYO3AOP1_RS07990	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SYO3AOP1_RS07990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYO3AOP1_RS07995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYO3AOP1_RS08005	COG0166	Belongs to the GPI family
SYO3AOP1_RS08015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SYO3AOP1_RS08040	COG1193	negative regulation of DNA recombination
SYO3AOP1_RS08055	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SYO3AOP1_RS08070	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SYO3AOP1_RS08075	COG0542	response to heat
SYO3AOP1_RS08080	COG1136	(ABC) transporter
SYO3AOP1_RS08090	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SYO3AOP1_RS08105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SYO3AOP1_RS08120	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SYO3AOP1_RS08130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SYO3AOP1_RS08140	COG0215	cysteine-tRNA ligase activity
SYO3AOP1_RS08165	COG1999	signal sequence binding
SYO3AOP1_RS08180	COG0445	tRNA wobble uridine modification
SYO3AOP1_RS08185	COG1923	regulation of RNA biosynthetic process
SYO3AOP1_RS08195	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SYO3AOP1_RS08200	COG5001	Diguanylate cyclase
SYO3AOP1_RS08200	COG5002	protein histidine kinase activity
SYO3AOP1_RS08215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SYO3AOP1_RS08230	COG0542	response to heat
SYO3AOP1_RS08265	COG0012	GTP binding
SYO3AOP1_RS08285	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SYO3AOP1_RS08290	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYO3AOP1_RS08295	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYO3AOP1_RS08300	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYO3AOP1_RS08310	COG1994	Peptidase M50
SYO3AOP1_RS08330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SYO3AOP1_RS08330	COG0519	Catalyzes the synthesis of GMP from XMP
SYO3AOP1_RS08345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SYO3AOP1_RS08350	COG1684	flagellar biosynthetic protein fliR
SYO3AOP1_RS08355	COG1987	bacterial-type flagellum assembly
SYO3AOP1_RS08360	COG1338	Plays a role in the flagellum-specific transport system
SYO3AOP1_RS08370	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SYO3AOP1_RS08375	COG1580	Controls the rotational direction of flagella during chemotaxis
SYO3AOP1_RS08385	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SYO3AOP1_RS08390	COG1157	protein secretion by the type III secretion system
SYO3AOP1_RS08400	COG1766	The M ring may be actively involved in energy transduction
SYO3AOP1_RS08405	COG1677	Flagellar hook-basal body complex protein FliE
SYO3AOP1_RS08410	COG1558	bacterial-type flagellum-dependent cell motility
SYO3AOP1_RS08415	COG1815	bacterial-type flagellum-dependent cell motility
SYO3AOP1_RS08430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYO3AOP1_RS08435	COG0455	bacterial-type flagellum organization
SYO3AOP1_RS08440	COG1419	protein localization to endoplasmic reticulum
SYO3AOP1_RS08445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SYO3AOP1_RS08455	COG1706	bacterial-type flagellum-dependent cell motility
SYO3AOP1_RS08460	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SYO3AOP1_RS08470	COG4786	Flagellar basal body rod
SYO3AOP1_RS08475	COG4786	Flagellar basal body rod
SYO3AOP1_RS08480	COG1776	CheC inhibitor of MCP methylation
SYO3AOP1_RS08480	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SYO3AOP1_RS08490	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SYO3AOP1_RS08500	COG3290	protein histidine kinase activity
SYO3AOP1_RS08500	COG0840	transmembrane signaling receptor activity
SYO3AOP1_RS08505	COG1110	DNA topoisomerase II activity
SYO3AOP1_RS08510	COG0251	oxidation-reduction process
SYO3AOP1_RS08515	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SYO3AOP1_RS08525	COG1191	sigma factor activity
SYO3AOP1_RS08530	COG0736	holo-[acyl-carrier-protein] synthase activity
SYO3AOP1_RS08540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SYO3AOP1_RS08545	COG1028	Short-chain dehydrogenase reductase Sdr
SYO3AOP1_RS08550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYO3AOP1_RS08555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYO3AOP1_RS08560	COG0571	ribonuclease III activity
SYO3AOP1_RS08565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SYO3AOP1_RS08570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SYO3AOP1_RS08595	COG3599	regulation of cell shape
SYO3AOP1_RS08595	COG1418	mRNA catabolic process
SYO3AOP1_RS08600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SYO3AOP1_RS08605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYO3AOP1_RS08605	COG0072	phenylalanine-tRNA ligase activity
SYO3AOP1_RS08610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SYO3AOP1_RS08615	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SYO3AOP1_RS08620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SYO3AOP1_RS08625	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SYO3AOP1_RS08630	COG0193	aminoacyl-tRNA hydrolase activity
SYO3AOP1_RS08635	COG0360	Binds together with S18 to 16S ribosomal RNA
SYO3AOP1_RS08640	COG0629	single-stranded DNA binding
SYO3AOP1_RS08645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SYO3AOP1_RS08650	COG0359	binds to the 23S rRNA
SYO3AOP1_RS08655	COG0305	Participates in initiation and elongation during chromosome replication
SYO3AOP1_RS08660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SYO3AOP1_RS08670	COG1187	pseudouridine synthase activity
SYO3AOP1_RS08675	COG2270	Major facilitator Superfamily
SYO3AOP1_RS08685	COG0442	prolyl-tRNA aminoacylation
SYO3AOP1_RS08695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYO3AOP1_RS08700	COG2050	protein possibly involved in aromatic compounds catabolism
SYO3AOP1_RS08700	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYO3AOP1_RS08705	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
SYO3AOP1_RS08725	COG2132	Multicopper oxidase
SYO3AOP1_RS08740	COG2239	Acts as a magnesium transporter
SYO3AOP1_RS08745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SYO3AOP1_RS08750	COG0101	tRNA pseudouridine synthase activity
SYO3AOP1_RS08755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SYO3AOP1_RS08760	COG3328	transposase activity
SYO3AOP1_RS08765	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SYO3AOP1_RS08795	COG0632	four-way junction helicase activity
SYO3AOP1_RS08800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SYO3AOP1_RS08815	COG0284	orotidine-5'-phosphate decarboxylase activity
SYO3AOP1_RS08820	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SYO3AOP1_RS08835	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SYO3AOP1_RS08840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SYO3AOP1_RS08845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SYO3AOP1_RS08850	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SYO3AOP1_RS08855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SYO3AOP1_RS08855	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SYO3AOP1_RS08860	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SYO3AOP1_RS08865	COG0047	phosphoribosylformylglycinamidine synthase activity
SYO3AOP1_RS08885	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SYO3AOP1_RS08890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYO3AOP1_RS08905	COG0439	Biotin carboxylase
SYO3AOP1_RS08910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYO3AOP1_RS08920	COG1459	type II secretion system
SYO3AOP1_RS08925	COG0482	sulfurtransferase activity
SYO3AOP1_RS08930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SYO3AOP1_RS08950	COG5002	protein histidine kinase activity
SYO3AOP1_RS08965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SYO3AOP1_RS08970	COG0438	transferase activity, transferring glycosyl groups
SYO3AOP1_RS08975	COG0726	polysaccharide deacetylase
SYO3AOP1_RS09005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYO3AOP1_RS09005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYO3AOP1_RS09020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SYO3AOP1_RS09025	COG0288	reversible hydration of carbon dioxide
SYO3AOP1_RS09030	COG0521	Mo-molybdopterin cofactor biosynthetic process
SYO3AOP1_RS09030	COG0315	cyclic pyranopterin monophosphate synthase activity
SYO3AOP1_RS09040	COG2703	oxygen carrier activity
SYO3AOP1_RS09045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYO3AOP1_RS09050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYO3AOP1_RS09055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYO3AOP1_RS09070	COG5002	protein histidine kinase activity
SYO3AOP1_RS09070	COG5001	Diguanylate cyclase
SYO3AOP1_RS09075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYO3AOP1_RS09085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SYO3AOP1_RS09155	COG3920	Histidine kinase