locus-tag	class	description
SMGD1_RS00030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMGD1_RS00040	COG1333	cytochrome c biogenesis protein
SMGD1_RS00040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMGD1_RS00060	COG3706	GGDEF domain
SMGD1_RS00080	COG0642	Histidine kinase
SMGD1_RS00085	COG1362	aminopeptidase activity
SMGD1_RS00090	COG0587	DNA-directed DNA polymerase activity
SMGD1_RS00115	COG2199	diguanylate cyclase activity
SMGD1_RS00115	COG2200	EAL domain
SMGD1_RS00115	COG3287	FIST C domain
SMGD1_RS00120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMGD1_RS00125	COG0343	queuine tRNA-ribosyltransferase activity
SMGD1_RS00140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMGD1_RS00160	COG1136	(ABC) transporter
SMGD1_RS00160	COG0577	efflux transmembrane transporter activity
SMGD1_RS00200	COG2890	protein-(glutamine-N5) methyltransferase activity
SMGD1_RS00205	COG0501	Belongs to the peptidase M48B family
SMGD1_RS00240	COG0673	inositol 2-dehydrogenase activity
SMGD1_RS00245	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMGD1_RS00255	COG4232	protein-disulfide reductase activity
SMGD1_RS00295	COG3258	Cytochrome c
SMGD1_RS00315	COG0642	Histidine kinase
SMGD1_RS00330	COG0784	Response regulator, receiver
SMGD1_RS00330	COG3437	response regulator, receiver
SMGD1_RS00335	COG5002	protein histidine kinase activity
SMGD1_RS00335	COG5001	Diguanylate cyclase
SMGD1_RS00335	COG3447	MASE1 domain protein
SMGD1_RS00340	COG3287	FIST C domain
SMGD1_RS00340	COG2200	EAL domain
SMGD1_RS00340	COG2199	diguanylate cyclase activity
SMGD1_RS00375	COG1331	Highly conserved protein containing a thioredoxin domain
SMGD1_RS00385	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SMGD1_RS00390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMGD1_RS00400	COG1408	metallophosphoesterase
SMGD1_RS00425	COG1355	regulation of microtubule-based process
SMGD1_RS00460	COG0390	transport system, permease component
SMGD1_RS00465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SMGD1_RS00470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMGD1_RS00480	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SMGD1_RS00500	COG1331	Highly conserved protein containing a thioredoxin domain
SMGD1_RS00520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMGD1_RS00540	COG1921	L-seryl-tRNASec selenium transferase activity
SMGD1_RS00545	COG0709	Synthesizes selenophosphate from selenide and ATP
SMGD1_RS00550	COG2391	methyltransferase activity
SMGD1_RS00555	COG0425	Belongs to the sulfur carrier protein TusA family
SMGD1_RS00565	COG2204	response regulator
SMGD1_RS00595	COG0243	molybdopterin cofactor binding
SMGD1_RS00605	COG0437	4 iron, 4 sulfur cluster binding
SMGD1_RS00615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SMGD1_RS00635	COG0303	'Molybdopterin
SMGD1_RS00640	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMGD1_RS00645	COG3842	ATPase activity
SMGD1_RS00655	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SMGD1_RS00665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMGD1_RS00675	COG0539	negative regulation of cytoplasmic translation
SMGD1_RS00675	COG1185	polyribonucleotide nucleotidyltransferase activity
SMGD1_RS00680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMGD1_RS00685	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMGD1_RS00690	COG0072	phenylalanine-tRNA ligase activity
SMGD1_RS00690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMGD1_RS00695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMGD1_RS00700	COG0537	adenosine 5'-monophosphoramidase activity
SMGD1_RS00710	COG2423	ornithine cyclodeaminase activity
SMGD1_RS00715	COG0189	ligase activity
SMGD1_RS00715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMGD1_RS00720	COG3246	L-lysine catabolic process to acetate
SMGD1_RS00730	COG0165	Argininosuccinate lyase
SMGD1_RS00740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMGD1_RS00745	COG0181	hydroxymethylbilane synthase activity
SMGD1_RS00760	COG0442	prolyl-tRNA aminoacylation
SMGD1_RS00765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMGD1_RS00770	COG0142	geranyltranstransferase activity
SMGD1_RS00785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMGD1_RS00790	COG1663	tetraacyldisaccharide 4'-kinase activity
SMGD1_RS00795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMGD1_RS00800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMGD1_RS00815	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMGD1_RS00815	COG2050	protein possibly involved in aromatic compounds catabolism
SMGD1_RS00820	COG0500	methyltransferase
SMGD1_RS00825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SMGD1_RS00835	COG1418	mRNA catabolic process
SMGD1_RS00850	COG0552	protein localization to endoplasmic reticulum
SMGD1_RS00860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SMGD1_RS00875	COG1580	Controls the rotational direction of flagella during chemotaxis
SMGD1_RS00880	COG0736	holo-[acyl-carrier-protein] synthase activity
SMGD1_RS00890	COG2197	response regulator
SMGD1_RS00925	COG1960	acyl-CoA dehydrogenase activity
SMGD1_RS00930	COG1024	Enoyl-CoA hydratase
SMGD1_RS00930	COG1250	3-hydroxyacyl-CoA dehydrogenase
SMGD1_RS00935	COG0183	Belongs to the thiolase family
SMGD1_RS00955	COG3287	FIST C domain
SMGD1_RS00955	COG2200	EAL domain
SMGD1_RS00955	COG2199	diguanylate cyclase activity
SMGD1_RS00965	COG1017	nitric oxide dioxygenase activity
SMGD1_RS00965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMGD1_RS00985	COG0306	phosphate transporter
SMGD1_RS01020	COG1484	DNA-dependent DNA replication
SMGD1_RS01025	COG4584	PFAM Integrase catalytic
SMGD1_RS01060	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS01070	COG2202	Pas domain
SMGD1_RS01070	COG2205	protein histidine kinase activity
SMGD1_RS01075	COG2205	protein histidine kinase activity
SMGD1_RS01085	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS01100	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS01105	COG2201	protein-glutamate methylesterase activity
SMGD1_RS01110	COG2200	EAL domain
SMGD1_RS01110	COG2199	diguanylate cyclase activity
SMGD1_RS01110	COG3287	FIST C domain
SMGD1_RS01115	COG2207	Transcriptional regulator
SMGD1_RS01115	COG4753	response regulator
SMGD1_RS01125	COG2204	response regulator
SMGD1_RS01130	COG3706	GGDEF domain
SMGD1_RS01145	COG2204	response regulator
SMGD1_RS01155	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS01160	COG2198	Histidine kinase
SMGD1_RS01160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMGD1_RS01160	COG0784	Response regulator, receiver
SMGD1_RS01160	COG2205	protein histidine kinase activity
SMGD1_RS01255	COG0514	ATP-dependent DNA helicase (RecQ)
SMGD1_RS01335	COG2963	transposase activity
SMGD1_RS01345	COG2801	Transposase and inactivated derivatives
SMGD1_RS01380	COG0275	rRNA processing
SMGD1_RS01385	COG2201	protein-glutamate methylesterase activity
SMGD1_RS01390	COG2151	metal-sulfur cluster biosynthetic enzyme
SMGD1_RS01405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMGD1_RS01410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMGD1_RS01415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMGD1_RS01435	COG2884	Cell division ATP-binding protein ftsE
SMGD1_RS01440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMGD1_RS01450	COG0564	pseudouridine synthase activity
SMGD1_RS01455	COG0772	Belongs to the SEDS family
SMGD1_RS01500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMGD1_RS01505	COG0154	amidase activity
SMGD1_RS01510	COG5001	Diguanylate cyclase
SMGD1_RS01510	COG3300	MHYT domain
SMGD1_RS01535	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS01540	COG0784	Response regulator, receiver
SMGD1_RS01540	COG2198	Histidine kinase
SMGD1_RS01540	COG5002	protein histidine kinase activity
SMGD1_RS01545	COG0516	GMP reductase activity
SMGD1_RS01545	COG0517	IMP dehydrogenase activity
SMGD1_RS01550	COG1714	RDD family
SMGD1_RS01560	COG0070	glutamate synthase
SMGD1_RS01560	COG0069	glutamate synthase activity
SMGD1_RS01560	COG0067	glutamate synthase
SMGD1_RS01580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMGD1_RS01590	COG3706	GGDEF domain
SMGD1_RS01595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMGD1_RS01615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMGD1_RS01625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMGD1_RS01645	COG1278	Cold shock
SMGD1_RS01650	COG1193	negative regulation of DNA recombination
SMGD1_RS01670	COG2081	HI0933 family
SMGD1_RS01675	COG3706	GGDEF domain
SMGD1_RS01680	COG5002	protein histidine kinase activity
SMGD1_RS01685	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS01690	COG1704	LemA family
SMGD1_RS01715	COG0437	4 iron, 4 sulfur cluster binding
SMGD1_RS01720	COG0348	domain, Protein
SMGD1_RS01740	COG0525	valine-tRNA ligase activity
SMGD1_RS01750	COG2199	diguanylate cyclase activity
SMGD1_RS01750	COG2200	EAL domain
SMGD1_RS01750	COG3287	FIST C domain
SMGD1_RS01765	COG2199	diguanylate cyclase activity
SMGD1_RS01765	COG2203	Gaf domain
SMGD1_RS01770	COG0659	secondary active sulfate transmembrane transporter activity
SMGD1_RS01785	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
SMGD1_RS01795	COG0134	indole-3-glycerol-phosphate synthase activity
SMGD1_RS01805	COG0727	PFAM Uncharacterised protein family (UPF0153)
SMGD1_RS01810	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMGD1_RS01815	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SMGD1_RS01825	COG0784	Response regulator, receiver
SMGD1_RS01825	COG2205	protein histidine kinase activity
SMGD1_RS01845	COG2198	Histidine kinase
SMGD1_RS01845	COG0643	Histidine kinase
SMGD1_RS01865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMGD1_RS01875	COG2201	protein-glutamate methylesterase activity
SMGD1_RS01880	COG0835	chemotaxis
SMGD1_RS01885	COG3290	protein histidine kinase activity
SMGD1_RS01885	COG0840	transmembrane signaling receptor activity
SMGD1_RS01890	COG0840	transmembrane signaling receptor activity
SMGD1_RS01895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMGD1_RS01900	COG5001	Diguanylate cyclase
SMGD1_RS01900	COG5002	protein histidine kinase activity
SMGD1_RS01910	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMGD1_RS01915	COG2404	hydrolase activity, acting on ester bonds
SMGD1_RS01930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMGD1_RS01940	COG1758	RNA polymerase activity
SMGD1_RS01945	COG0528	UMP kinase activity
SMGD1_RS01950	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS01955	COG4191	Histidine kinase
SMGD1_RS01960	COG2200	EAL domain
SMGD1_RS01960	COG2199	diguanylate cyclase activity
SMGD1_RS01960	COG3287	FIST C domain
SMGD1_RS01970	COG0243	molybdopterin cofactor binding
SMGD1_RS01980	COG0437	4 iron, 4 sulfur cluster binding
SMGD1_RS01985	COG0457	Tetratricopeptide repeat
SMGD1_RS01985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMGD1_RS01990	COG2201	protein-glutamate methylesterase activity
SMGD1_RS01995	COG0840	transmembrane signaling receptor activity
SMGD1_RS02000	COG2223	nitrite transmembrane transporter activity
SMGD1_RS02015	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMGD1_RS02020	COG2066	Belongs to the glutaminase family
SMGD1_RS02025	COG1944	ATP diphosphatase activity
SMGD1_RS02030	COG0513	Belongs to the DEAD box helicase family
SMGD1_RS02035	COG2199	diguanylate cyclase activity
SMGD1_RS02035	COG3287	FIST C domain
SMGD1_RS02035	COG2200	EAL domain
SMGD1_RS02045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SMGD1_RS02045	COG1116	anion transmembrane transporter activity
SMGD1_RS02055	COG1116	anion transmembrane transporter activity
SMGD1_RS02065	COG0515	serine threonine protein kinase
SMGD1_RS02070	COG2902	Dehydrogenase
SMGD1_RS02080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMGD1_RS02085	COG0339	signal peptide processing
SMGD1_RS02095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMGD1_RS02115	COG3437	response regulator, receiver
SMGD1_RS02115	COG0784	Response regulator, receiver
SMGD1_RS02125	COG3706	GGDEF domain
SMGD1_RS02150	COG0284	orotidine-5'-phosphate decarboxylase activity
SMGD1_RS02155	COG0840	transmembrane signaling receptor activity
SMGD1_RS02160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMGD1_RS02165	COG2176	DNA-directed DNA polymerase activity
SMGD1_RS02195	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS02200	COG0642	Histidine kinase
SMGD1_RS02205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMGD1_RS02210	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMGD1_RS02215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMGD1_RS02220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMGD1_RS02225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMGD1_RS02230	COG1077	Cell shape determining protein MreB Mrl
SMGD1_RS02245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMGD1_RS02265	COG0754	glutathionylspermidine amidase activity
SMGD1_RS02275	COG1086	Polysaccharide biosynthesis protein
SMGD1_RS02280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMGD1_RS02295	COG2963	transposase activity
SMGD1_RS02305	COG1086	Polysaccharide biosynthesis protein
SMGD1_RS02315	COG0367	asparagine synthase
SMGD1_RS02350	COG0463	Glycosyl transferase, family 2
SMGD1_RS02380	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMGD1_RS02385	COG1088	dTDP-glucose 4,6-dehydratase activity
SMGD1_RS02390	COG1091	dTDP-4-dehydrorhamnose reductase activity
SMGD1_RS02410	COG2226	methyltransferase
SMGD1_RS02420	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SMGD1_RS02425	COG0438	transferase activity, transferring glycosyl groups
SMGD1_RS02435	COG0579	oxidoreductase
SMGD1_RS02450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMGD1_RS02455	COG0175	sulfate reduction
SMGD1_RS02460	COG2895	sulfate adenylyltransferase (ATP) activity
SMGD1_RS02465	COG0529	Catalyzes the synthesis of activated sulfate
SMGD1_RS02470	COG0529	Catalyzes the synthesis of activated sulfate
SMGD1_RS02490	COG1088	dTDP-glucose 4,6-dehydratase activity
SMGD1_RS02500	COG2963	transposase activity
SMGD1_RS02510	COG0463	Glycosyl transferase, family 2
SMGD1_RS02510	COG1216	Glycosyl transferase, family 2
SMGD1_RS02520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMGD1_RS02525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMGD1_RS02540	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
SMGD1_RS02545	COG2089	acid synthase
SMGD1_RS02560	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
SMGD1_RS02565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMGD1_RS02575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMGD1_RS02580	COG1086	Polysaccharide biosynthesis protein
SMGD1_RS02585	COG1132	(ABC) transporter
SMGD1_RS02590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMGD1_RS02595	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SMGD1_RS02605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SMGD1_RS02615	COG0166	Belongs to the GPI family
SMGD1_RS02620	COG1793	dna ligase
SMGD1_RS02630	COG1216	Glycosyl transferase, family 2
SMGD1_RS02635	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMGD1_RS02640	COG1028	Short-chain dehydrogenase reductase Sdr
SMGD1_RS02640	COG3347	Dehydrogenase
SMGD1_RS02645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMGD1_RS02650	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
SMGD1_RS02655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMGD1_RS02660	COG1070	Carbohydrate kinase
SMGD1_RS02665	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SMGD1_RS02670	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SMGD1_RS02675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMGD1_RS02685	COG0489	protein tyrosine kinase activity
SMGD1_RS02690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMGD1_RS02695	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMGD1_RS02695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMGD1_RS02700	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS02705	COG2046	Belongs to the sulfate adenylyltransferase family
SMGD1_RS02735	COG0668	transmembrane transport
SMGD1_RS02740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMGD1_RS02745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMGD1_RS02750	COG1053	succinate dehydrogenase
SMGD1_RS02760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMGD1_RS02770	COG0840	transmembrane signaling receptor activity
SMGD1_RS02800	COG0439	Biotin carboxylase
SMGD1_RS02805	COG0439	Biotin carboxylase
SMGD1_RS02820	COG2501	S4 domain
SMGD1_RS02835	COG1278	Cold shock
SMGD1_RS02845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMGD1_RS02850	COG0857	belongs to the CobB CobQ family
SMGD1_RS02850	COG0280	phosphate acetyltransferase
SMGD1_RS02855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMGD1_RS02870	COG3290	protein histidine kinase activity
SMGD1_RS02870	COG0840	transmembrane signaling receptor activity
SMGD1_RS02875	COG0488	(ABC) transporter
SMGD1_RS02890	COG3706	GGDEF domain
SMGD1_RS02890	COG4251	negative regulation of phosphorylation
SMGD1_RS02890	COG5001	Diguanylate cyclase
SMGD1_RS02890	COG2203	Gaf domain
SMGD1_RS02905	COG0243	molybdopterin cofactor binding
SMGD1_RS02910	COG0437	4 iron, 4 sulfur cluster binding
SMGD1_RS02915	COG0348	domain, Protein
SMGD1_RS02920	COG3043	anaerobic respiration
SMGD1_RS02950	COG0006	proline dipeptidase activity
SMGD1_RS02965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMGD1_RS02970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMGD1_RS02975	COG0835	chemotaxis
SMGD1_RS02980	COG2198	Histidine kinase
SMGD1_RS02980	COG0643	Histidine kinase
SMGD1_RS02980	COG0784	Response regulator, receiver
SMGD1_RS02985	COG0835	chemotaxis
SMGD1_RS02985	COG0784	Response regulator, receiver
SMGD1_RS02995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMGD1_RS03000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMGD1_RS03040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMGD1_RS03045	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SMGD1_RS03065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMGD1_RS03080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SMGD1_RS03085	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SMGD1_RS03095	COG2200	EAL domain
SMGD1_RS03100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMGD1_RS03110	COG2198	Histidine kinase
SMGD1_RS03110	COG5002	protein histidine kinase activity
SMGD1_RS03110	COG0784	Response regulator, receiver
SMGD1_RS03115	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS03125	COG5002	protein histidine kinase activity
SMGD1_RS03135	COG1692	metallophosphoesterase
SMGD1_RS03140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMGD1_RS03150	COG0739	heme binding
SMGD1_RS03155	COG0285	dihydrofolate synthase activity
SMGD1_RS03170	COG0495	leucyl-tRNA aminoacylation
SMGD1_RS03195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMGD1_RS03200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMGD1_RS03205	COG1862	Preprotein translocase
SMGD1_RS03210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SMGD1_RS03220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMGD1_RS03225	COG2860	membrane
SMGD1_RS03230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMGD1_RS03235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMGD1_RS03240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMGD1_RS03255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SMGD1_RS03260	COG0135	phosphoribosylanthranilate isomerase activity
SMGD1_RS03265	COG2176	DNA-directed DNA polymerase activity
SMGD1_RS03270	COG0825	malonyl-CoA metabolic process
SMGD1_RS03275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMGD1_RS03280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMGD1_RS03290	COG0702	epimerase
SMGD1_RS03295	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SMGD1_RS03300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMGD1_RS03360	COG2200	EAL domain
SMGD1_RS03360	COG3287	FIST C domain
SMGD1_RS03360	COG2199	diguanylate cyclase activity
SMGD1_RS03365	COG3706	GGDEF domain
SMGD1_RS03425	COG2354	Protein conserved in bacteria
SMGD1_RS03430	COG1254	Belongs to the acylphosphatase family
SMGD1_RS03440	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMGD1_RS03440	COG2199	diguanylate cyclase activity
SMGD1_RS03450	COG1592	Rubrerythrin
SMGD1_RS03460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMGD1_RS03465	COG0481	GTPase activity
SMGD1_RS03485	COG3287	FIST C domain
SMGD1_RS03485	COG2200	EAL domain
SMGD1_RS03485	COG2199	diguanylate cyclase activity
SMGD1_RS03500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMGD1_RS03505	COG0443	Heat shock 70 kDa protein
SMGD1_RS03520	COG3437	response regulator, receiver
SMGD1_RS03540	COG0784	Response regulator, receiver
SMGD1_RS03540	COG3437	response regulator, receiver
SMGD1_RS03550	COG4999	Histidine kinase
SMGD1_RS03550	COG3850	Histidine kinase
SMGD1_RS03550	COG2205	protein histidine kinase activity
SMGD1_RS03550	COG3437	response regulator, receiver
SMGD1_RS03555	COG3920	Histidine kinase
SMGD1_RS03565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMGD1_RS03595	COG0793	Belongs to the peptidase S41A family
SMGD1_RS03600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMGD1_RS03605	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMGD1_RS03610	COG0047	phosphoribosylformylglycinamidine synthase activity
SMGD1_RS03620	COG0204	Acyl-transferase
SMGD1_RS03625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMGD1_RS03630	COG4608	Belongs to the ABC transporter superfamily
SMGD1_RS03645	COG3787	Belongs to the UPF0306 family
SMGD1_RS03655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMGD1_RS03665	COG1496	oxidoreductase activity
SMGD1_RS03670	COG0590	tRNA wobble adenosine to inosine editing
SMGD1_RS03675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMGD1_RS03685	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMGD1_RS03695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMGD1_RS03700	COG1605	Chorismate mutase
SMGD1_RS03700	COG0077	Prephenate dehydratase
SMGD1_RS03710	COG0019	diaminopimelate decarboxylase activity
SMGD1_RS03720	COG0193	aminoacyl-tRNA hydrolase activity
SMGD1_RS03725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SMGD1_RS03745	COG3852	Histidine kinase
SMGD1_RS03750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMGD1_RS03755	COG0540	Belongs to the ATCase OTCase family
SMGD1_RS03760	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMGD1_RS03765	COG2873	o-acetylhomoserine
SMGD1_RS03770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMGD1_RS03775	COG0542	response to heat
SMGD1_RS03780	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SMGD1_RS03815	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMGD1_RS03820	COG0335	large ribosomal subunit rRNA binding
SMGD1_RS03825	COG0336	Belongs to the RNA methyltransferase TrmD family
SMGD1_RS03830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMGD1_RS03840	COG0228	four-way junction DNA binding
SMGD1_RS03845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMGD1_RS03850	COG0564	pseudouridine synthase activity
SMGD1_RS03855	COG1519	Transferase
SMGD1_RS03865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SMGD1_RS03880	COG0739	heme binding
SMGD1_RS03885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMGD1_RS03895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMGD1_RS03900	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SMGD1_RS03905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMGD1_RS03910	COG0210	DNA helicase
SMGD1_RS03925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMGD1_RS03935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMGD1_RS03965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMGD1_RS03970	COG1185	polyribonucleotide nucleotidyltransferase activity
SMGD1_RS03980	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SMGD1_RS04000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMGD1_RS04000	COG0519	Catalyzes the synthesis of GMP from XMP
SMGD1_RS04005	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SMGD1_RS04010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SMGD1_RS04020	COG0322	excinuclease ABC activity
SMGD1_RS04025	COG0840	transmembrane signaling receptor activity
SMGD1_RS04040	COG0784	Response regulator, receiver
SMGD1_RS04040	COG2205	protein histidine kinase activity
SMGD1_RS04045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMGD1_RS04050	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMGD1_RS04055	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SMGD1_RS04080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SMGD1_RS04085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMGD1_RS04090	COG0612	Peptidase, M16
SMGD1_RS04095	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMGD1_RS04110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMGD1_RS04115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMGD1_RS04120	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SMGD1_RS04130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SMGD1_RS04160	COG1160	GTP binding
SMGD1_RS04165	COG1981	membrane
SMGD1_RS04195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMGD1_RS04200	COG0113	porphobilinogen synthase activity
SMGD1_RS04205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMGD1_RS04280	COG0357	Ribosomal RNA small subunit methyltransferase G
SMGD1_RS04295	COG0791	NLP P60 protein
SMGD1_RS04295	COG3883	PFAM NLP P60 protein
SMGD1_RS04305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMGD1_RS04315	COG2957	Belongs to the agmatine deiminase family
SMGD1_RS04330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMGD1_RS04335	COG0305	Participates in initiation and elongation during chromosome replication
SMGD1_RS04340	COG0658	competence protein
SMGD1_RS04340	COG2333	competence protein COMEC
SMGD1_RS04350	COG0277	FAD linked oxidase domain protein
SMGD1_RS04360	COG0739	heme binding
SMGD1_RS04370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMGD1_RS04385	COG1815	bacterial-type flagellum-dependent cell motility
SMGD1_RS04390	COG1558	bacterial-type flagellum-dependent cell motility
SMGD1_RS04405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMGD1_RS04410	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMGD1_RS04435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMGD1_RS04440	COG0049	tRNA binding
SMGD1_RS04445	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMGD1_RS04450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMGD1_RS04455	COG0085	RNA polymerase activity
SMGD1_RS04460	COG0222	ribosome binding
SMGD1_RS04465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMGD1_RS04470	COG0081	regulation of translation
SMGD1_RS04475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMGD1_RS04480	COG0250	Participates in transcription elongation, termination and antitermination
SMGD1_RS04495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMGD1_RS04520	COG0784	Response regulator, receiver
SMGD1_RS04520	COG3437	response regulator, receiver
SMGD1_RS04535	COG3022	response to hydroperoxide
SMGD1_RS04540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMGD1_RS04550	COG0300	oxidoreductase activity
SMGD1_RS04555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMGD1_RS04590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SMGD1_RS04600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMGD1_RS04605	COG0142	geranyltranstransferase activity
SMGD1_RS04620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMGD1_RS04625	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SMGD1_RS04640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMGD1_RS04645	COG0584	glycerophosphoryl diester phosphodiesterase
SMGD1_RS04650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMGD1_RS04670	COG0203	ribosomal protein L17
SMGD1_RS04675	COG0202	RNA polymerase activity
SMGD1_RS04680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMGD1_RS04685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMGD1_RS04690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMGD1_RS04695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMGD1_RS04705	COG3706	GGDEF domain
SMGD1_RS04740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMGD1_RS04745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SMGD1_RS04775	COG0133	tryptophan synthase activity
SMGD1_RS04800	COG2169	Transcriptional regulator
SMGD1_RS04800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMGD1_RS04835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMGD1_RS04840	COG0024	Methionine aminopeptidase
SMGD1_RS04845	COG0201	protein transport
SMGD1_RS04850	COG0200	Binds to the 23S rRNA
SMGD1_RS04855	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMGD1_RS04860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMGD1_RS04865	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMGD1_RS04870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMGD1_RS04875	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMGD1_RS04880	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMGD1_RS04885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMGD1_RS04890	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMGD1_RS04895	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMGD1_RS04900	COG0255	Belongs to the universal ribosomal protein uL29 family
SMGD1_RS04905	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMGD1_RS04915	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMGD1_RS04920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMGD1_RS04925	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMGD1_RS04930	COG0089	rRNA binding
SMGD1_RS04935	COG0088	Forms part of the polypeptide exit tunnel
SMGD1_RS04940	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMGD1_RS04955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMGD1_RS04970	COG0303	'Molybdopterin
SMGD1_RS04975	COG0314	molybdopterin synthase activity
SMGD1_RS04985	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMGD1_RS04990	COG1858	cytochrome C peroxidase
SMGD1_RS04995	COG3287	FIST C domain
SMGD1_RS04995	COG2199	diguanylate cyclase activity
SMGD1_RS04995	COG2200	EAL domain
SMGD1_RS05000	COG0281	malic enzyme
SMGD1_RS05045	COG0733	neurotransmitter:sodium symporter activity
SMGD1_RS05055	COG3706	GGDEF domain
SMGD1_RS05060	COG2022	thiamine diphosphate biosynthetic process
SMGD1_RS05065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMGD1_RS05065	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SMGD1_RS05070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMGD1_RS05080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SMGD1_RS05080	COG0517	IMP dehydrogenase activity
SMGD1_RS05085	COG1187	pseudouridine synthase activity
SMGD1_RS05090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMGD1_RS05090	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMGD1_RS05100	COG0840	transmembrane signaling receptor activity
SMGD1_RS05105	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS05110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMGD1_RS05115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMGD1_RS05135	COG1472	Belongs to the glycosyl hydrolase 3 family
SMGD1_RS05145	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SMGD1_RS05155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMGD1_RS05180	COG4221	oxidoreductase activity
SMGD1_RS05195	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SMGD1_RS05200	COG2089	acid synthase
SMGD1_RS05210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMGD1_RS05220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMGD1_RS05230	COG0107	imidazoleglycerol-phosphate synthase activity
SMGD1_RS05260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMGD1_RS05265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMGD1_RS05275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMGD1_RS05280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMGD1_RS05285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMGD1_RS05290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMGD1_RS05295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMGD1_RS05300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMGD1_RS05310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMGD1_RS05315	COG0569	domain protein
SMGD1_RS05315	COG0475	glutathione-regulated potassium exporter activity
SMGD1_RS05325	COG0492	ferredoxin-NADP+ reductase activity
SMGD1_RS05355	COG0367	asparagine synthase
SMGD1_RS05360	COG2203	Gaf domain
SMGD1_RS05360	COG2199	diguanylate cyclase activity
SMGD1_RS05370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMGD1_RS05375	COG0330	HflC and HflK could
SMGD1_RS05400	COG1393	Belongs to the ArsC family
SMGD1_RS05410	COG0590	tRNA wobble adenosine to inosine editing
SMGD1_RS05420	COG3706	GGDEF domain
SMGD1_RS05430	COG2201	protein-glutamate methylesterase activity
SMGD1_RS05435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMGD1_RS05445	COG1132	(ABC) transporter
SMGD1_RS05450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMGD1_RS05515	COG0642	Histidine kinase
SMGD1_RS05520	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS05530	COG2217	Heavy metal translocating P-type atpase
SMGD1_RS05555	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMGD1_RS05575	COG3706	GGDEF domain
SMGD1_RS05580	COG2259	Doxx family
SMGD1_RS05590	COG0840	transmembrane signaling receptor activity
SMGD1_RS05640	COG0077	Prephenate dehydratase
SMGD1_RS05640	COG1605	Chorismate mutase
SMGD1_RS05645	COG2199	diguanylate cyclase activity
SMGD1_RS05645	COG2203	Gaf domain
SMGD1_RS05650	COG2183	response to ionizing radiation
SMGD1_RS05670	COG2199	diguanylate cyclase activity
SMGD1_RS05670	COG3287	FIST C domain
SMGD1_RS05670	COG2200	EAL domain
SMGD1_RS05680	COG3706	GGDEF domain
SMGD1_RS05690	COG0488	(ABC) transporter
SMGD1_RS05695	COG1451	nucleotide metabolic process
SMGD1_RS05705	COG0513	Belongs to the DEAD box helicase family
SMGD1_RS05710	COG4895	conserved protein (DUF2196)
SMGD1_RS05715	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SMGD1_RS05735	COG0822	iron-sulfur transferase activity
SMGD1_RS05735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SMGD1_RS05735	COG2906	2 iron, 2 sulfur cluster binding
SMGD1_RS05750	COG3706	GGDEF domain
SMGD1_RS05760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMGD1_RS05770	COG0746	molybdenum cofactor guanylyltransferase activity
SMGD1_RS05775	COG0315	cyclic pyranopterin monophosphate synthase activity
SMGD1_RS05840	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMGD1_RS05870	COG0840	transmembrane signaling receptor activity
SMGD1_RS05875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMGD1_RS05880	COG0571	ribonuclease III activity
SMGD1_RS05885	COG0328	RNA-DNA hybrid ribonuclease activity
SMGD1_RS05910	COG2855	membrane
SMGD1_RS05920	COG0348	domain, Protein
SMGD1_RS05925	COG0840	transmembrane signaling receptor activity
SMGD1_RS05930	COG0646	methionine synthase
SMGD1_RS05930	COG1410	methionine synthase
SMGD1_RS05960	COG2267	carboxylic ester hydrolase activity
SMGD1_RS05965	COG0242	peptide deformylase activity
SMGD1_RS05975	COG0740	serine-type endopeptidase activity
SMGD1_RS05980	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMGD1_RS05995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMGD1_RS06000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMGD1_RS06005	COG0268	Binds directly to 16S ribosomal RNA
SMGD1_RS06010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMGD1_RS06015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMGD1_RS06020	COG0237	dephospho-CoA kinase activity
SMGD1_RS06025	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SMGD1_RS06080	COG0670	Belongs to the BI1 family
SMGD1_RS06085	COG0352	thiamine-phosphate diphosphorylase activity
SMGD1_RS06095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMGD1_RS06100	COG1121	(ABC) transporter
SMGD1_RS06105	COG3443	Belongs to the bacterial solute-binding protein 9 family
SMGD1_RS06105	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMGD1_RS06110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMGD1_RS06115	COG0233	cytoplasmic translational termination
SMGD1_RS06120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMGD1_RS06130	COG0504	CTP synthase activity
SMGD1_RS06135	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SMGD1_RS06135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SMGD1_RS06160	COG1157	protein secretion by the type III secretion system
SMGD1_RS06170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SMGD1_RS06175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMGD1_RS06185	COG0107	imidazoleglycerol-phosphate synthase activity
SMGD1_RS06195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMGD1_RS06205	COG0564	pseudouridine synthase activity
SMGD1_RS06210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMGD1_RS06215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMGD1_RS06225	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SMGD1_RS06230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMGD1_RS06235	COG3118	belongs to the thioredoxin family
SMGD1_RS06240	COG0372	Belongs to the citrate synthase family
SMGD1_RS06245	COG3123	guanosine phosphorylase activity
SMGD1_RS06255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SMGD1_RS06260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMGD1_RS06265	COG0592	DNA-directed DNA polymerase activity
SMGD1_RS06270	COG0187	DNA topoisomerase II activity
SMGD1_RS06275	COG5001	Diguanylate cyclase
SMGD1_RS06280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMGD1_RS06295	COG1217	gtp-binding protein TYPA
SMGD1_RS06310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMGD1_RS06310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMGD1_RS06320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMGD1_RS06340	COG0242	peptide deformylase activity
SMGD1_RS06345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMGD1_RS06365	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
SMGD1_RS06390	COG2824	Alkylphosphonate utilization operon protein PhnA
SMGD1_RS06400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SMGD1_RS06410	COG0840	transmembrane signaling receptor activity
SMGD1_RS06410	COG3290	protein histidine kinase activity
SMGD1_RS06415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SMGD1_RS06420	COG0358	DNA primase activity
SMGD1_RS06430	COG0482	sulfurtransferase activity
SMGD1_RS06450	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SMGD1_RS06460	COG1749	Flagellar hook protein flgE
SMGD1_RS06465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMGD1_RS06470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMGD1_RS06485	COG1858	cytochrome C peroxidase
SMGD1_RS06490	COG0784	Response regulator, receiver
SMGD1_RS06490	COG2205	protein histidine kinase activity
SMGD1_RS06495	COG1053	succinate dehydrogenase
SMGD1_RS06510	COG1666	GTP binding
SMGD1_RS06520	COG3706	GGDEF domain
SMGD1_RS06540	COG0840	transmembrane signaling receptor activity
SMGD1_RS06545	COG5001	Diguanylate cyclase
SMGD1_RS06555	COG0840	transmembrane signaling receptor activity
SMGD1_RS06560	COG1032	radical SAM domain protein
SMGD1_RS06565	COG0840	transmembrane signaling receptor activity
SMGD1_RS06575	COG2814	Major facilitator Superfamily
SMGD1_RS06590	COG0668	transmembrane transport
SMGD1_RS06625	COG3746	phosphate-selective porin O and P
SMGD1_RS06640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMGD1_RS06640	COG0574	Belongs to the PEP-utilizing enzyme family
SMGD1_RS06645	COG0840	transmembrane signaling receptor activity
SMGD1_RS06655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMGD1_RS06660	COG0840	transmembrane signaling receptor activity
SMGD1_RS06665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMGD1_RS06670	COG1234	tRNA 3'-trailer cleavage
SMGD1_RS06675	COG0686	Belongs to the AlaDH PNT family
SMGD1_RS06680	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SMGD1_RS06685	COG5001	Diguanylate cyclase
SMGD1_RS06685	COG3706	GGDEF domain
SMGD1_RS06685	COG2203	Gaf domain
SMGD1_RS06685	COG4251	negative regulation of phosphorylation
SMGD1_RS06690	COG1492	cobalamin metabolic process
SMGD1_RS06700	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SMGD1_RS06705	COG0778	Nitroreductase
SMGD1_RS06710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMGD1_RS06715	COG1122	ATPase activity
SMGD1_RS06725	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SMGD1_RS06735	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMGD1_RS06750	COG5001	Diguanylate cyclase
SMGD1_RS06750	COG5002	protein histidine kinase activity
SMGD1_RS06770	COG0575	Belongs to the CDS family
SMGD1_RS06775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SMGD1_RS06780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMGD1_RS06785	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMGD1_RS06805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMGD1_RS06810	COG1987	bacterial-type flagellum assembly
SMGD1_RS06815	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMGD1_RS06820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMGD1_RS06825	COG0148	phosphopyruvate hydratase activity
SMGD1_RS06870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMGD1_RS06875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMGD1_RS06895	COG2986	histidine ammonia-lyase
SMGD1_RS06905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMGD1_RS06920	COG1131	(ABC) transporter
SMGD1_RS06995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMGD1_RS07005	COG2239	Acts as a magnesium transporter
SMGD1_RS07010	COG1253	flavin adenine dinucleotide binding
SMGD1_RS07035	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS07045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMGD1_RS07045	COG1648	precorrin-2 dehydrogenase activity
SMGD1_RS07055	COG0535	radical SAM domain protein
SMGD1_RS07065	COG2010	Cytochrome c
SMGD1_RS07070	COG3256	nitric oxide reductase
SMGD1_RS07105	COG1858	cytochrome C peroxidase
SMGD1_RS07120	COG1960	acyl-CoA dehydrogenase activity
SMGD1_RS07130	COG1028	Short-chain dehydrogenase reductase Sdr
SMGD1_RS07140	COG0300	oxidoreductase activity
SMGD1_RS07145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMGD1_RS07165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMGD1_RS07165	COG1648	precorrin-2 dehydrogenase activity
SMGD1_RS07170	COG1522	sequence-specific DNA binding
SMGD1_RS07185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMGD1_RS07190	COG1741	Belongs to the pirin family
SMGD1_RS07200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMGD1_RS07205	COG1012	belongs to the aldehyde dehydrogenase family
SMGD1_RS07240	COG4681	YaeQ
SMGD1_RS07250	COG5002	protein histidine kinase activity
SMGD1_RS07250	COG3850	Histidine kinase
SMGD1_RS07270	COG3706	GGDEF domain
SMGD1_RS07280	COG4067	protein conserved in archaea
SMGD1_RS07280	COG0189	ligase activity
SMGD1_RS07285	COG0189	ligase activity
SMGD1_RS07300	COG2116	formate transmembrane transporter activity
SMGD1_RS07305	COG1971	Probably functions as a manganese efflux pump
SMGD1_RS07335	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SMGD1_RS07375	COG1047	Peptidyl-prolyl cis-trans
SMGD1_RS07390	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS07395	COG0642	Histidine kinase
SMGD1_RS07415	COG3153	acetyltransferase
SMGD1_RS07415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMGD1_RS07445	COG0840	transmembrane signaling receptor activity
SMGD1_RS07455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SMGD1_RS07485	COG0129	dihydroxy-acid dehydratase activity
SMGD1_RS07495	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMGD1_RS07500	COG2814	Major facilitator Superfamily
SMGD1_RS07505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMGD1_RS07510	COG1968	undecaprenyl-diphosphatase activity
SMGD1_RS07520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMGD1_RS07525	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMGD1_RS07530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMGD1_RS07550	COG0505	Belongs to the CarA family
SMGD1_RS07555	COG3278	Belongs to the heme-copper respiratory oxidase family
SMGD1_RS07595	COG1074	ATP-dependent DNA helicase activity
SMGD1_RS07605	COG1279	arginine transmembrane transporter activity
SMGD1_RS07615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMGD1_RS07620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMGD1_RS07630	COG0747	negative chemotaxis
SMGD1_RS07645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMGD1_RS07650	COG1144	Oxidoreductase
SMGD1_RS07655	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMGD1_RS07660	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMGD1_RS07665	COG1854	S-ribosylhomocysteine lyase activity
SMGD1_RS07680	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SMGD1_RS07685	COG3290	protein histidine kinase activity
SMGD1_RS07685	COG0840	transmembrane signaling receptor activity
SMGD1_RS07705	COG0445	tRNA wobble uridine modification
SMGD1_RS07715	COG0723	plastoquinol--plastocyanin reductase activity
SMGD1_RS07720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMGD1_RS07745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMGD1_RS07750	COG0602	queuosine metabolic process
SMGD1_RS07775	COG0254	rRNA binding
SMGD1_RS07780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SMGD1_RS07800	COG0436	Aminotransferase
SMGD1_RS07805	COG0460	homoserine dehydrogenase
SMGD1_RS07810	COG3383	formate dehydrogenase (NAD+) activity
SMGD1_RS07815	COG0792	nuclease activity
SMGD1_RS07830	COG1012	belongs to the aldehyde dehydrogenase family
SMGD1_RS07840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMGD1_RS07850	COG0840	transmembrane signaling receptor activity
SMGD1_RS07855	COG0424	maF-like protein
SMGD1_RS07865	COG3706	GGDEF domain
SMGD1_RS07870	COG0156	8-amino-7-oxononanoate synthase activity
SMGD1_RS07885	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SMGD1_RS07890	COG0444	Belongs to the ABC transporter superfamily
SMGD1_RS07895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMGD1_RS07920	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS07930	COG0513	Belongs to the DEAD box helicase family
SMGD1_RS07985	COG1136	(ABC) transporter
SMGD1_RS07985	COG0577	efflux transmembrane transporter activity
SMGD1_RS08010	COG5002	protein histidine kinase activity
SMGD1_RS08015	COG0642	Histidine kinase
SMGD1_RS08020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMGD1_RS08030	COG0174	glutamine synthetase
SMGD1_RS08045	COG0704	Plays a role in the regulation of phosphate uptake
SMGD1_RS08050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMGD1_RS08055	COG0581	inorganic phosphate transmembrane transporter activity
SMGD1_RS08060	COG0573	inorganic phosphate transmembrane transporter activity
SMGD1_RS08065	COG0306	phosphate transporter
SMGD1_RS08080	COG2326	polyphosphate kinase activity
SMGD1_RS08090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMGD1_RS08095	COG0484	heat shock protein binding
SMGD1_RS08120	COG2226	methyltransferase
SMGD1_RS08150	COG0140	phosphoribosyl-ATP diphosphatase activity
SMGD1_RS08150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMGD1_RS08165	COG1242	4 iron, 4 sulfur cluster binding
SMGD1_RS08170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMGD1_RS08175	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMGD1_RS08180	COG0492	ferredoxin-NADP+ reductase activity
SMGD1_RS08190	COG3118	belongs to the thioredoxin family
SMGD1_RS08215	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMGD1_RS08225	COG0826	peptidase U32
SMGD1_RS08230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMGD1_RS08245	COG0752	glycyl-tRNA synthetase alpha subunit
SMGD1_RS08250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMGD1_RS08255	COG1090	epimerase
SMGD1_RS08265	COG2078	PFAM AMMECR1 domain protein
SMGD1_RS08265	COG3885	ferrous iron binding
SMGD1_RS08270	COG1355	regulation of microtubule-based process
SMGD1_RS08280	COG3842	ATPase activity
SMGD1_RS08315	COG3437	response regulator, receiver
SMGD1_RS08340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMGD1_RS08345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMGD1_RS08355	COG0484	heat shock protein binding
SMGD1_RS08375	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SMGD1_RS08385	COG1222	aaa ATPase
SMGD1_RS08390	COG0688	phosphatidylethanolamine metabolic process
SMGD1_RS08395	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMGD1_RS08400	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMGD1_RS08405	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMGD1_RS08410	COG0649	NAD binding
SMGD1_RS08430	COG1034	ATP synthesis coupled electron transport
SMGD1_RS08440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMGD1_RS08445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMGD1_RS08450	COG0839	Belongs to the complex I subunit 6 family
SMGD1_RS08455	COG0713	ATP synthesis coupled electron transport
SMGD1_RS08460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMGD1_RS08470	COG1007	ATP synthesis coupled electron transport
SMGD1_RS08485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMGD1_RS08505	COG0772	Belongs to the SEDS family
SMGD1_RS08510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMGD1_RS08515	COG0586	Pfam SNARE associated Golgi protein
SMGD1_RS08525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SMGD1_RS08535	COG0052	Belongs to the universal ribosomal protein uS2 family
SMGD1_RS08540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMGD1_RS08570	COG0437	4 iron, 4 sulfur cluster binding
SMGD1_RS08585	COG1136	(ABC) transporter
SMGD1_RS08590	COG1684	flagellar biosynthetic protein fliR
SMGD1_RS08600	COG0194	GDP metabolic process
SMGD1_RS08605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMGD1_RS08610	COG0018	arginyl-trna synthetase
SMGD1_RS08625	COG1757	Na H antiporter
SMGD1_RS08650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMGD1_RS08670	COG4948	Mandelate Racemase Muconate Lactonizing
SMGD1_RS08685	COG4206	TonB-dependent receptor
SMGD1_RS08715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMGD1_RS08725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMGD1_RS08730	COG3864	Putative metallopeptidase domain
SMGD1_RS08740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMGD1_RS08750	COG0450	alkyl hydroperoxide reductase
SMGD1_RS08755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMGD1_RS08765	COG0105	UTP biosynthetic process
SMGD1_RS08775	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMGD1_RS08780	COG0416	fatty acid biosynthetic process
SMGD1_RS08785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMGD1_RS08800	COG0513	Belongs to the DEAD box helicase family
SMGD1_RS08805	COG3706	GGDEF domain
SMGD1_RS08815	COG1322	Protein conserved in bacteria
SMGD1_RS08820	COG0784	Response regulator, receiver
SMGD1_RS08820	COG4191	Histidine kinase
SMGD1_RS08850	COG2207	Transcriptional regulator
SMGD1_RS08850	COG4753	response regulator
SMGD1_RS08860	COG0668	transmembrane transport
SMGD1_RS08870	COG0784	Response regulator, receiver
SMGD1_RS08870	COG2205	protein histidine kinase activity
SMGD1_RS08880	COG5002	protein histidine kinase activity
SMGD1_RS08880	COG2205	protein histidine kinase activity
SMGD1_RS08880	COG0784	Response regulator, receiver
SMGD1_RS08890	COG1183	phosphatidylcholine synthase activity
SMGD1_RS08900	COG1918	ferrous iron import across plasma membrane
SMGD1_RS08905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMGD1_RS08910	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS08915	COG0642	Histidine kinase
SMGD1_RS08920	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SMGD1_RS08925	COG0799	negative regulation of ribosome biogenesis
SMGD1_RS08930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMGD1_RS08935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMGD1_RS08940	COG0126	phosphoglycerate kinase activity
SMGD1_RS08945	COG0149	triose-phosphate isomerase activity
SMGD1_RS08950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMGD1_RS08965	COG0195	Participates in both transcription termination and antitermination
SMGD1_RS08975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMGD1_RS08980	COG2121	Domain of unknown function (DUF374)
SMGD1_RS08990	COG4974	Belongs to the 'phage' integrase family
SMGD1_RS09010	COG0037	tRNA processing
SMGD1_RS09015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMGD1_RS09020	COG2081	HI0933 family
SMGD1_RS09045	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMGD1_RS09055	COG0556	nucleotide-excision repair
SMGD1_RS09060	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMGD1_RS09120	COG5000	phosphorelay sensor kinase activity
SMGD1_RS09135	COG0793	Belongs to the peptidase S41A family
SMGD1_RS09150	COG0159	tryptophan synthase activity
SMGD1_RS09160	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMGD1_RS09165	COG2255	four-way junction helicase activity
SMGD1_RS09170	COG0628	permease
SMGD1_RS09175	COG1560	Kdo2-lipid A biosynthetic process
SMGD1_RS09205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMGD1_RS09210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMGD1_RS09215	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS09220	COG2264	protein methyltransferase activity
SMGD1_RS09225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMGD1_RS09235	COG1183	phosphatidylcholine synthase activity
SMGD1_RS09245	COG2326	polyphosphate kinase activity
SMGD1_RS09255	COG1214	PFAM Peptidase M22, glycoprotease
SMGD1_RS09255	COG0456	acetyltransferase
SMGD1_RS09265	COG2239	Acts as a magnesium transporter
SMGD1_RS09285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMGD1_RS09290	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMGD1_RS09290	COG2199	diguanylate cyclase activity
SMGD1_RS09300	COG0560	Phosphoserine phosphatase
SMGD1_RS09315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMGD1_RS09320	COG0629	single-stranded DNA binding
SMGD1_RS09325	COG0360	Binds together with S18 to 16S ribosomal RNA
SMGD1_RS09330	COG2861	carbohydrate metabolic process
SMGD1_RS09340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMGD1_RS09345	COG0805	protein transport
SMGD1_RS09355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMGD1_RS09360	COG3287	FIST C domain
SMGD1_RS09360	COG2200	EAL domain
SMGD1_RS09360	COG2199	diguanylate cyclase activity
SMGD1_RS09365	COG0494	nUDIX hydrolase
SMGD1_RS09370	COG0527	aspartate kinase activity
SMGD1_RS09385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMGD1_RS09390	COG3706	GGDEF domain
SMGD1_RS09395	COG0306	phosphate transporter
SMGD1_RS09400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMGD1_RS09410	COG0776	regulation of translation
SMGD1_RS09450	COG2226	methyltransferase
SMGD1_RS09460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMGD1_RS09470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMGD1_RS09485	COG0542	response to heat
SMGD1_RS09495	COG2199	diguanylate cyclase activity
SMGD1_RS09495	COG2200	EAL domain
SMGD1_RS09495	COG3287	FIST C domain
SMGD1_RS09500	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMGD1_RS09505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMGD1_RS09510	COG0706	membrane insertase activity
SMGD1_RS09520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMGD1_RS09525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMGD1_RS09535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMGD1_RS09550	COG0557	exoribonuclease II activity
SMGD1_RS09565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMGD1_RS09570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMGD1_RS09595	COG0205	6-phosphofructokinase activity
SMGD1_RS09600	COG0784	Response regulator, receiver
SMGD1_RS09600	COG3437	response regulator, receiver
SMGD1_RS09610	COG0484	heat shock protein binding
SMGD1_RS09620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMGD1_RS09650	COG0742	ribosomal rna small subunit methyltransferase
SMGD1_RS09655	COG1706	bacterial-type flagellum-dependent cell motility
SMGD1_RS09660	COG3951	Flagellar rod assembly protein muramidase FlgJ
SMGD1_RS09680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMGD1_RS09685	COG0628	permease
SMGD1_RS09695	COG0512	Glutamine amidotransferase of anthranilate synthase
SMGD1_RS09740	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SMGD1_RS09755	COG2217	Heavy metal translocating P-type atpase
SMGD1_RS09775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SMGD1_RS09775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SMGD1_RS09830	COG1696	Membrane protein involved in D-alanine export
SMGD1_RS09845	COG0438	transferase activity, transferring glycosyl groups
SMGD1_RS09875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMGD1_RS09885	COG1132	(ABC) transporter
SMGD1_RS09890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMGD1_RS09895	COG0247	lactate metabolic process
SMGD1_RS09900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMGD1_RS09910	COG3287	FIST C domain
SMGD1_RS09910	COG2199	diguanylate cyclase activity
SMGD1_RS09910	COG2200	EAL domain
SMGD1_RS09915	COG0513	Belongs to the DEAD box helicase family
SMGD1_RS09920	COG3706	GGDEF domain
SMGD1_RS09930	COG0564	pseudouridine synthase activity
SMGD1_RS09995	COG1674	ftsk spoiiie
SMGD1_RS10025	COG3706	GGDEF domain
SMGD1_RS10030	COG0784	Response regulator, receiver
SMGD1_RS10030	COG3437	response regulator, receiver
SMGD1_RS10035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SMGD1_RS10075	COG3279	Response regulator of the LytR AlgR family
SMGD1_RS10110	COG1858	cytochrome C peroxidase
SMGD1_RS10115	COG4999	Histidine kinase
SMGD1_RS10115	COG3850	Histidine kinase
SMGD1_RS10115	COG3437	response regulator, receiver
SMGD1_RS10115	COG2205	protein histidine kinase activity
SMGD1_RS10125	COG0514	ATP-dependent DNA helicase (RecQ)
SMGD1_RS10190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMGD1_RS10220	COG1674	ftsk spoiiie
SMGD1_RS10280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMGD1_RS10335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMGD1_RS10340	COG0459	protein refolding
SMGD1_RS10355	COG3706	GGDEF domain
SMGD1_RS10360	COG5001	Diguanylate cyclase
SMGD1_RS10365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMGD1_RS10375	COG0848	biopolymer transport protein
SMGD1_RS10380	COG0811	peptide transport
SMGD1_RS10385	COG5002	protein histidine kinase activity
SMGD1_RS10390	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS10395	COG0418	dihydroorotase activity
SMGD1_RS10400	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SMGD1_RS10415	COG0308	aminopeptidase N
SMGD1_RS10425	COG0242	peptide deformylase activity
SMGD1_RS10435	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS10450	COG2207	Transcriptional regulator
SMGD1_RS10450	COG4753	response regulator
SMGD1_RS10455	COG2827	Endonuclease containing a URI domain
SMGD1_RS10460	COG1671	Belongs to the UPF0178 family
SMGD1_RS10495	COG0840	transmembrane signaling receptor activity
SMGD1_RS10505	COG0643	Histidine kinase
SMGD1_RS10505	COG2198	Histidine kinase
SMGD1_RS10520	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SMGD1_RS10525	COG2201	protein-glutamate methylesterase activity
SMGD1_RS10545	COG3437	response regulator, receiver
SMGD1_RS10545	COG2770	Histidine kinase
SMGD1_RS10560	COG0840	transmembrane signaling receptor activity
SMGD1_RS10565	COG0840	transmembrane signaling receptor activity
SMGD1_RS10610	COG3706	GGDEF domain
SMGD1_RS10620	COG1196	nuclear chromosome segregation
SMGD1_RS10620	COG3264	Mechanosensitive ion channel
SMGD1_RS10625	COG3706	GGDEF domain
SMGD1_RS10645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMGD1_RS10660	COG0731	radical SAM domain protein
SMGD1_RS10665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SMGD1_RS10675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMGD1_RS10680	COG2204	response regulator
SMGD1_RS10700	COG0004	ammonium transporteR
SMGD1_RS10710	COG0004	ammonium transporteR
SMGD1_RS10725	COG3437	response regulator, receiver
SMGD1_RS10785	COG0714	Associated with various cellular activities
SMGD1_RS10790	COG3706	GGDEF domain
SMGD1_RS10810	COG2304	oxidoreductase activity
SMGD1_RS10815	COG2304	oxidoreductase activity
SMGD1_RS10825	COG0287	Prephenate dehydrogenase
SMGD1_RS10830	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMGD1_RS10840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMGD1_RS10845	COG0642	Histidine kinase
SMGD1_RS10850	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS10860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMGD1_RS10870	COG0157	Belongs to the NadC ModD family
SMGD1_RS10875	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMGD1_RS10890	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SMGD1_RS10900	COG0083	homoserine kinase activity
SMGD1_RS10910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMGD1_RS10920	COG0779	Required for maturation of 30S ribosomal subunits
SMGD1_RS10925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMGD1_RS10925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMGD1_RS10930	COG2226	methyltransferase
SMGD1_RS10935	COG1570	exodeoxyribonuclease VII activity
SMGD1_RS10945	COG0616	signal peptide processing
SMGD1_RS10950	COG0402	S-adenosylhomocysteine deaminase activity
SMGD1_RS10960	COG0579	oxidoreductase
SMGD1_RS10970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMGD1_RS10975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMGD1_RS10980	COG1419	protein localization to endoplasmic reticulum
SMGD1_RS10985	COG0455	bacterial-type flagellum organization
SMGD1_RS11005	COG1776	CheC inhibitor of MCP methylation
SMGD1_RS11005	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMGD1_RS11010	COG1611	Belongs to the LOG family
SMGD1_RS11015	COG0482	sulfurtransferase activity
SMGD1_RS11040	COG0617	tRNA 3'-terminal CCA addition
SMGD1_RS11075	COG2197	response regulator
SMGD1_RS11085	COG2274	protein secretion by the type I secretion system
SMGD1_RS11100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SMGD1_RS11115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMGD1_RS11125	COG0251	oxidation-reduction process
SMGD1_RS11130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMGD1_RS11145	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS11150	COG0642	Histidine kinase
SMGD1_RS11155	COG1309	transcriptional regulator
SMGD1_RS11185	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS11190	COG0642	Histidine kinase
SMGD1_RS11195	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SMGD1_RS11200	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SMGD1_RS11205	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
SMGD1_RS11225	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SMGD1_RS11235	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SMGD1_RS11240	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SMGD1_RS11245	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
SMGD1_RS11250	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SMGD1_RS11255	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMGD1_RS11260	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMGD1_RS11275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SMGD1_RS11280	COG0298	carbon dioxide binding
SMGD1_RS11285	COG0409	Hydrogenase expression formation protein
SMGD1_RS11290	COG3177	Filamentation induced by cAMP protein fic
SMGD1_RS11300	COG1401	restriction endodeoxyribonuclease activity
SMGD1_RS11305	COG4628	conserved protein (DUF2132)
SMGD1_RS11315	COG0667	Aldo Keto reductase
SMGD1_RS11320	COG0309	Hydrogenase expression formation protein (HypE)
SMGD1_RS11330	COG0375	protein maturation
SMGD1_RS11335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMGD1_RS11340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMGD1_RS11345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMGD1_RS11350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMGD1_RS11355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMGD1_RS11360	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SMGD1_RS11360	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SMGD1_RS11365	COG1192	Involved in chromosome partitioning
SMGD1_RS11370	COG1475	DNA binding
SMGD1_RS11385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMGD1_RS11390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMGD1_RS11395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMGD1_RS11400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMGD1_RS11405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMGD1_RS11410	COG0811	peptide transport
SMGD1_RS11415	COG0848	biopolymer transport protein
SMGD1_RS11425	COG0823	Involved in the tonB-independent uptake of proteins
SMGD1_RS11430	COG2885	chlorophyll binding
SMGD1_RS11440	COG1047	Peptidyl-prolyl cis-trans
SMGD1_RS11450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMGD1_RS11455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMGD1_RS11455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMGD1_RS11460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMGD1_RS11465	COG0037	tRNA processing
SMGD1_RS11480	COG0217	transcriptional regulatory protein
SMGD1_RS11485	COG1739	Uncharacterized protein family UPF0029
SMGD1_RS11495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMGD1_RS11550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SMGD1_RS11555	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SMGD1_RS11560	COG0359	binds to the 23S rRNA
SMGD1_RS11570	COG0137	argininosuccinate synthase activity
SMGD1_RS11595	COG2199	diguanylate cyclase activity
SMGD1_RS11595	COG3287	FIST C domain
SMGD1_RS11595	COG2200	EAL domain
SMGD1_RS11605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMGD1_RS11620	COG0196	riboflavin kinase activity
SMGD1_RS11625	COG0585	pseudouridine synthase activity
SMGD1_RS11630	COG0356	it plays a direct role in the translocation of protons across the membrane
SMGD1_RS11640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMGD1_RS11645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMGD1_RS11655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMGD1_RS11665	COG0471	metal ion transport
SMGD1_RS11690	COG2954	triphosphatase activity
SMGD1_RS11700	COG0840	transmembrane signaling receptor activity
SMGD1_RS11710	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SMGD1_RS11720	COG1131	(ABC) transporter
SMGD1_RS11725	COG0348	domain, Protein
SMGD1_RS11735	COG2863	cytochrome
SMGD1_RS11740	COG0437	4 iron, 4 sulfur cluster binding
SMGD1_RS11755	COG4263	nitrous-oxide reductase activity
SMGD1_RS11780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMGD1_RS11785	COG0849	cell division
SMGD1_RS11795	COG2199	diguanylate cyclase activity
SMGD1_RS11800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMGD1_RS11815	COG3706	GGDEF domain
SMGD1_RS11825	COG4145	pantothenate transmembrane transporter activity
SMGD1_RS11830	COG0484	heat shock protein binding
SMGD1_RS11835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SMGD1_RS11840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMGD1_RS11845	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
SMGD1_RS11865	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SMGD1_RS11870	COG2315	Protein conserved in bacteria
SMGD1_RS11875	COG0659	secondary active sulfate transmembrane transporter activity
SMGD1_RS11880	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SMGD1_RS11890	COG0038	chloride channel
SMGD1_RS11895	COG2111	Na H antiporter
SMGD1_RS11895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMGD1_RS11905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMGD1_RS11925	COG1741	Belongs to the pirin family
SMGD1_RS11945	COG0590	tRNA wobble adenosine to inosine editing
SMGD1_RS11950	COG3261	NADH dehydrogenase
SMGD1_RS11950	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SMGD1_RS11960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMGD1_RS11965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMGD1_RS11980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMGD1_RS11995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMGD1_RS12010	COG3706	GGDEF domain
SMGD1_RS12015	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMGD1_RS12025	COG0488	(ABC) transporter
SMGD1_RS12035	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMGD1_RS12065	COG0642	Histidine kinase
SMGD1_RS12070	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS12080	COG0326	Molecular chaperone. Has ATPase activity
SMGD1_RS12100	COG2814	Major facilitator Superfamily
SMGD1_RS12105	COG3630	sodium ion export across plasma membrane
SMGD1_RS12110	COG0511	ligase activity, forming carbon-carbon bonds
SMGD1_RS12110	COG5016	pyruvate
SMGD1_RS12120	COG2197	response regulator
SMGD1_RS12130	COG3287	FIST C domain
SMGD1_RS12130	COG2199	diguanylate cyclase activity
SMGD1_RS12130	COG2200	EAL domain
SMGD1_RS12135	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS12140	COG2198	Histidine kinase
SMGD1_RS12140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMGD1_RS12140	COG0784	Response regulator, receiver
SMGD1_RS12140	COG2205	protein histidine kinase activity
SMGD1_RS12155	COG2201	protein-glutamate methylesterase activity
SMGD1_RS12160	COG0784	Response regulator, receiver
SMGD1_RS12160	COG0835	chemotaxis
SMGD1_RS12180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMGD1_RS12215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMGD1_RS12230	COG4974	Belongs to the 'phage' integrase family
SMGD1_RS12260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMGD1_RS12260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMGD1_RS12270	COG3287	FIST C domain
SMGD1_RS12270	COG2199	diguanylate cyclase activity
SMGD1_RS12270	COG2200	EAL domain
SMGD1_RS12275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMGD1_RS12290	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS12295	COG1643	Atp-dependent helicase
SMGD1_RS12300	COG3706	GGDEF domain
SMGD1_RS12305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMGD1_RS12330	COG0352	thiamine-phosphate diphosphorylase activity
SMGD1_RS12340	COG2081	HI0933 family
SMGD1_RS12380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMGD1_RS12385	COG0750	zinc metalloprotease
SMGD1_RS12390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMGD1_RS12410	COG1028	Short-chain dehydrogenase reductase Sdr
SMGD1_RS12415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMGD1_RS12435	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SMGD1_RS12465	COG4191	Histidine kinase
SMGD1_RS12495	COG0482	sulfurtransferase activity
SMGD1_RS12515	COG1959	2 iron, 2 sulfur cluster binding
SMGD1_RS12520	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMGD1_RS12525	COG2895	sulfate adenylyltransferase (ATP) activity
SMGD1_RS12530	COG0175	sulfate reduction
SMGD1_RS12535	COG0175	sulfate reduction
SMGD1_RS12545	COG0840	transmembrane signaling receptor activity
SMGD1_RS12545	COG3290	protein histidine kinase activity
SMGD1_RS12565	COG1902	pentaerythritol trinitrate reductase activity
SMGD1_RS12570	COG0563	adenylate kinase activity
SMGD1_RS12575	COG0612	Peptidase, M16
SMGD1_RS12580	COG0167	dihydroorotate dehydrogenase activity
SMGD1_RS12600	COG0116	Belongs to the methyltransferase superfamily
SMGD1_RS12600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMGD1_RS12605	COG0215	cysteine-tRNA ligase activity
SMGD1_RS12610	COG2020	methyltransferase activity
SMGD1_RS12620	COG2081	HI0933 family
SMGD1_RS12625	COG0488	(ABC) transporter
SMGD1_RS12680	COG4584	PFAM Integrase catalytic
SMGD1_RS12685	COG1484	DNA-dependent DNA replication
SMGD1_RS12700	COG0582	viral genome integration into host DNA
SMGD1_RS12705	COG0728	peptidoglycan biosynthetic process
SMGD1_RS12725	COG0632	four-way junction helicase activity
SMGD1_RS12740	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMGD1_RS12750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMGD1_RS12770	COG0739	heme binding
SMGD1_RS12775	COG1017	nitric oxide dioxygenase activity
SMGD1_RS12775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SMGD1_RS12790	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS12795	COG0642	Histidine kinase
SMGD1_RS12825	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS12850	COG1730	sister chromatid segregation
SMGD1_RS12865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMGD1_RS12870	COG1752	Esterase of the alpha-beta hydrolase superfamily
SMGD1_RS12895	COG0500	methyltransferase
SMGD1_RS12905	COG0070	glutamate synthase
SMGD1_RS12905	COG0069	glutamate synthase activity
SMGD1_RS12905	COG0067	glutamate synthase
SMGD1_RS12910	COG0067	glutamate synthase
SMGD1_RS12910	COG0069	glutamate synthase activity
SMGD1_RS12910	COG0070	glutamate synthase
SMGD1_RS12915	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMGD1_RS12915	COG0493	'glutamate synthase
SMGD1_RS12935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMGD1_RS12940	COG0352	thiamine-phosphate diphosphorylase activity
SMGD1_RS12945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMGD1_RS12960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMGD1_RS12975	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMGD1_RS12985	COG0730	response to heat
SMGD1_RS12990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMGD1_RS13000	COG3706	GGDEF domain
SMGD1_RS13010	COG1733	regulation of RNA biosynthetic process
SMGD1_RS13015	COG1979	alcohol dehydrogenase
SMGD1_RS13020	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMGD1_RS13030	COG0778	Nitroreductase
SMGD1_RS13040	COG3437	response regulator, receiver
SMGD1_RS13045	COG2205	protein histidine kinase activity
SMGD1_RS13045	COG0784	Response regulator, receiver
SMGD1_RS13050	COG1227	inorganic diphosphatase activity
SMGD1_RS13065	COG1032	radical SAM domain protein
SMGD1_RS13070	COG0840	transmembrane signaling receptor activity
SMGD1_RS13075	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMGD1_RS13080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMGD1_RS13085	COG0802	atpase or kinase
SMGD1_RS13090	COG1137	ATPase activity
SMGD1_RS13095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMGD1_RS13110	COG0784	Response regulator, receiver
SMGD1_RS13110	COG5002	protein histidine kinase activity
SMGD1_RS13135	COG1832	CoA-binding protein
SMGD1_RS13140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMGD1_RS13150	COG0028	Belongs to the TPP enzyme family
SMGD1_RS13155	COG0440	acetolactate synthase activity
SMGD1_RS13160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMGD1_RS13175	COG0436	Aminotransferase
SMGD1_RS13180	COG1045	serine acetyltransferase
SMGD1_RS13185	COG1166	arginine decarboxylase activity
SMGD1_RS13190	COG0069	glutamate synthase activity
SMGD1_RS13195	COG0124	histidyl-tRNA synthetase
SMGD1_RS13205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMGD1_RS13210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMGD1_RS13215	COG0163	prenyltransferase activity
SMGD1_RS13230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMGD1_RS13235	COG1196	nuclear chromosome segregation
SMGD1_RS13235	COG1674	ftsk spoiiie
SMGD1_RS13245	COG0114	fumarate hydratase activity
SMGD1_RS13250	COG1049	propionate catabolic process, 2-methylcitrate cycle
SMGD1_RS13255	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SMGD1_RS13260	COG0653	protein targeting
SMGD1_RS13265	COG4591	ABC-type transport system involved in lipoprotein release permease component
SMGD1_RS13285	COG0039	L-malate dehydrogenase activity
SMGD1_RS13295	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SMGD1_RS13300	COG0039	L-malate dehydrogenase activity
SMGD1_RS13315	COG0045	succinate-CoA ligase (ADP-forming) activity
SMGD1_RS13320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SMGD1_RS13330	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMGD1_RS13330	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMGD1_RS13335	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMGD1_RS13345	COG1309	transcriptional regulator
SMGD1_RS13370	COG3706	GGDEF domain
SMGD1_RS13375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMGD1_RS13380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMGD1_RS13390	COG0741	lytic transglycosylase activity
SMGD1_RS13405	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SMGD1_RS13415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMGD1_RS13415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMGD1_RS13430	COG1215	transferase activity, transferring glycosyl groups
SMGD1_RS13435	COG0726	polysaccharide deacetylase
SMGD1_RS13435	COG1649	PFAM Uncharacterised BCR, COG1649
SMGD1_RS13450	COG4865	methylaspartate mutase activity
SMGD1_RS13455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SMGD1_RS13460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMGD1_RS13470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SMGD1_RS13485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMGD1_RS13495	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMGD1_RS13505	COG0768	penicillin binding
SMGD1_RS13520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMGD1_RS13535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SMGD1_RS13540	COG0131	Imidazoleglycerol-phosphate dehydratase
SMGD1_RS13545	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMGD1_RS13555	COG0084	hydrolase, TatD family'
SMGD1_RS13560	COG0497	DNA recombination
SMGD1_RS13565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMGD1_RS13570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMGD1_RS13575	COG0563	adenylate kinase activity
SMGD1_RS13580	COG2205	protein histidine kinase activity
SMGD1_RS13580	COG0784	Response regulator, receiver
SMGD1_RS13585	COG0745	RESPONSE REGULATOR receiver
SMGD1_RS13590	COG0642	Histidine kinase
SMGD1_RS13600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SMGD1_RS13620	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SMGD1_RS13635	COG2171	N-acyltransferase activity
SMGD1_RS13660	COG0788	formyltetrahydrofolate deformylase activity
SMGD1_RS13675	COG0473	3-isopropylmalate dehydrogenase activity
SMGD1_RS13680	COG0066	3-isopropylmalate dehydratase activity
SMGD1_RS13690	COG0840	transmembrane signaling receptor activity
SMGD1_RS13705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMGD1_RS13725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMGD1_RS13750	COG2311	Membrane
SMGD1_RS13755	COG0471	metal ion transport
SMGD1_RS13795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMGD1_RS13800	COG0681	Belongs to the peptidase S26 family
SMGD1_RS13805	COG1994	Peptidase M50
SMGD1_RS13810	COG0698	ribose 5-phosphate isomerase
SMGD1_RS13820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMGD1_RS13825	COG0133	tryptophan synthase activity
SMGD1_RS13830	COG2226	methyltransferase
SMGD1_RS13840	COG1272	protein, Hemolysin III
SMGD1_RS13845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMGD1_RS13895	COG2200	EAL domain
SMGD1_RS13895	COG2199	diguanylate cyclase activity
SMGD1_RS13895	COG3287	FIST C domain
SMGD1_RS13900	COG0012	GTP binding
SMGD1_RS13920	COG0585	pseudouridine synthase activity
SMGD1_RS13945	COG2048	Heterodisulfide reductase, subunit B
SMGD1_RS13950	COG0708	Exodeoxyribonuclease III
SMGD1_RS13960	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMGD1_RS13970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMGD1_RS13975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMGD1_RS13985	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMGD1_RS13995	COG0514	ATP-dependent DNA helicase (RecQ)
SMGD1_RS14010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMGD1_RS14015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMGD1_RS14060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMGD1_RS14065	COG1338	Plays a role in the flagellum-specific transport system
SMGD1_RS14070	COG1360	Flagellar Motor Protein
SMGD1_RS14075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SMGD1_RS14110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMGD1_RS14115	COG0840	transmembrane signaling receptor activity
SMGD1_RS14120	COG0840	transmembrane signaling receptor activity
SMGD1_RS14130	COG0419	ATPase involved in DNA repair
SMGD1_RS14155	COG0475	glutathione-regulated potassium exporter activity
SMGD1_RS14175	COG2963	transposase activity
SMGD1_RS14185	COG0500	methyltransferase
SMGD1_RS14190	COG0301	tRNA thio-modification
SMGD1_RS14190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMGD1_RS14210	COG0534	Mate efflux family protein
SMGD1_RS14225	COG0513	Belongs to the DEAD box helicase family
SMGD1_RS14235	COG3437	response regulator, receiver
SMGD1_RS14245	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SMGD1_RS14275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMGD1_RS14290	COG0101	tRNA pseudouridine synthase activity
SMGD1_RS14300	COG0822	iron-sulfur transferase activity
SMGD1_RS14310	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SMGD1_RS14325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMGD1_RS14325	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SMGD1_RS14355	COG0840	transmembrane signaling receptor activity
SMGD1_RS14365	COG2200	EAL domain
SMGD1_RS14365	COG3287	FIST C domain
SMGD1_RS14365	COG2199	diguanylate cyclase activity
SMGD1_RS14370	COG1573	uracil-dna glycosylase
SMGD1_RS14380	COG0824	Thioesterase
SMGD1_RS14385	COG0387	Pfam Sodium calcium exchanger
SMGD1_RS14390	COG2239	Acts as a magnesium transporter
SMGD1_RS14395	COG3706	GGDEF domain
SMGD1_RS14405	COG1132	(ABC) transporter
SMGD1_RS14410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMGD1_RS14440	COG4191	Histidine kinase
SMGD1_RS14460	COG3328	transposase activity
SMGD1_RS14495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP