locus-tag	class	description
ETP70_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ETP70_RS00015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ETP70_RS00020	COG3123	guanosine phosphorylase activity
ETP70_RS00030	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ETP70_RS00040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ETP70_RS00045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ETP70_RS00050	COG0564	pseudouridine synthase activity
ETP70_RS00055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ETP70_RS00065	COG0107	imidazoleglycerol-phosphate synthase activity
ETP70_RS00075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ETP70_RS00080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ETP70_RS00085	COG0302	gtp cyclohydrolase
ETP70_RS00090	COG1157	protein secretion by the type III secretion system
ETP70_RS00105	COG0504	CTP synthase activity
ETP70_RS00120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ETP70_RS00125	COG3443	Belongs to the bacterial solute-binding protein 9 family
ETP70_RS00125	COG0803	Belongs to the bacterial solute-binding protein 9 family
ETP70_RS00130	COG1121	(ABC) transporter
ETP70_RS00135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ETP70_RS00145	COG0352	thiamine-phosphate diphosphorylase activity
ETP70_RS00150	COG0670	Belongs to the BI1 family
ETP70_RS00190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ETP70_RS00200	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ETP70_RS00205	COG0237	dephospho-CoA kinase activity
ETP70_RS00210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ETP70_RS00215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ETP70_RS00220	COG0268	Binds directly to 16S ribosomal RNA
ETP70_RS00225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ETP70_RS00230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ETP70_RS00235	COG0544	peptidyl-prolyl cis-trans isomerase activity
ETP70_RS00240	COG0740	serine-type endopeptidase activity
ETP70_RS00250	COG0242	peptide deformylase activity
ETP70_RS00255	COG0606	chelatase, subunit chli
ETP70_RS00275	COG1410	methionine synthase
ETP70_RS00275	COG0646	methionine synthase
ETP70_RS00285	COG0348	domain, Protein
ETP70_RS00290	COG2855	membrane
ETP70_RS00305	COG0328	RNA-DNA hybrid ribonuclease activity
ETP70_RS00310	COG0571	ribonuclease III activity
ETP70_RS00315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ETP70_RS00375	COG0315	cyclic pyranopterin monophosphate synthase activity
ETP70_RS00380	COG0746	molybdenum cofactor guanylyltransferase activity
ETP70_RS00390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ETP70_RS00400	COG1104	cysteine desulfurase activity
ETP70_RS00415	COG3300	MHYT domain
ETP70_RS00415	COG5001	Diguanylate cyclase
ETP70_RS00420	COG0642	Histidine kinase
ETP70_RS00425	COG0745	RESPONSE REGULATOR receiver
ETP70_RS00455	COG3287	FIST C domain
ETP70_RS00455	COG2200	EAL domain
ETP70_RS00455	COG2199	diguanylate cyclase activity
ETP70_RS00460	COG0745	RESPONSE REGULATOR receiver
ETP70_RS00465	COG0513	Belongs to the DEAD box helicase family
ETP70_RS00470	COG0488	(ABC) transporter
ETP70_RS00500	COG0069	glutamate synthase activity
ETP70_RS00520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ETP70_RS00520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ETP70_RS00525	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ETP70_RS00535	COG2217	Heavy metal translocating P-type atpase
ETP70_RS00560	COG2132	Multicopper oxidase
ETP70_RS00570	COG4232	protein-disulfide reductase activity
ETP70_RS00595	COG0745	RESPONSE REGULATOR receiver
ETP70_RS00600	COG0642	Histidine kinase
ETP70_RS00605	COG2193	ferroxidase activity
ETP70_RS00610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ETP70_RS00615	COG2270	Major facilitator Superfamily
ETP70_RS00645	COG2199	diguanylate cyclase activity
ETP70_RS00650	COG1194	a g-specific adenine glycosylase
ETP70_RS00655	COG1132	(ABC) transporter
ETP70_RS00665	COG1858	cytochrome C peroxidase
ETP70_RS00670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ETP70_RS00680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ETP70_RS00725	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ETP70_RS00735	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ETP70_RS00740	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETP70_RS00765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ETP70_RS00770	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ETP70_RS00790	COG2203	Gaf domain
ETP70_RS00790	COG4251	negative regulation of phosphorylation
ETP70_RS00790	COG5001	Diguanylate cyclase
ETP70_RS00790	COG3706	GGDEF domain
ETP70_RS00805	COG1858	cytochrome C peroxidase
ETP70_RS00810	COG1643	Atp-dependent helicase
ETP70_RS00855	COG0129	dihydroxy-acid dehydratase activity
ETP70_RS00865	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ETP70_RS00895	COG4263	nitrous-oxide reductase activity
ETP70_RS00910	COG0437	4 iron, 4 sulfur cluster binding
ETP70_RS00915	COG2863	cytochrome
ETP70_RS00925	COG0348	domain, Protein
ETP70_RS00930	COG1131	(ABC) transporter
ETP70_RS00945	COG0840	transmembrane signaling receptor activity
ETP70_RS00960	COG2814	Major facilitator Superfamily
ETP70_RS00965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ETP70_RS00970	COG1968	undecaprenyl-diphosphatase activity
ETP70_RS00975	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ETP70_RS00980	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ETP70_RS00985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ETP70_RS01005	COG0505	Belongs to the CarA family
ETP70_RS01010	COG3278	Belongs to the heme-copper respiratory oxidase family
ETP70_RS01060	COG1074	ATP-dependent DNA helicase activity
ETP70_RS01080	COG0840	transmembrane signaling receptor activity
ETP70_RS01085	COG0322	excinuclease ABC activity
ETP70_RS01100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ETP70_RS01105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ETP70_RS01110	COG0519	Catalyzes the synthesis of GMP from XMP
ETP70_RS01110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ETP70_RS01140	COG1185	polyribonucleotide nucleotidyltransferase activity
ETP70_RS01145	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ETP70_RS01155	COG5001	Diguanylate cyclase
ETP70_RS01155	COG5002	protein histidine kinase activity
ETP70_RS01160	COG5001	Diguanylate cyclase
ETP70_RS01160	COG5002	protein histidine kinase activity
ETP70_RS01165	COG3842	ATPase activity
ETP70_RS01185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ETP70_RS01190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ETP70_RS01200	COG4166	transmembrane transport
ETP70_RS01210	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ETP70_RS01215	COG1144	Oxidoreductase
ETP70_RS01220	COG0674	pyruvate-flavodoxin oxidoreductase activity
ETP70_RS01225	COG1013	pyruvate-flavodoxin oxidoreductase activity
ETP70_RS01250	COG1854	S-ribosylhomocysteine lyase activity
ETP70_RS01265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ETP70_RS01275	COG0514	ATP-dependent DNA helicase (RecQ)
ETP70_RS01295	COG0445	tRNA wobble uridine modification
ETP70_RS01305	COG0723	plastoquinol--plastocyanin reductase activity
ETP70_RS01310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ETP70_RS01325	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ETP70_RS01330	COG0602	queuosine metabolic process
ETP70_RS01340	COG0719	Fe-S assembly protein
ETP70_RS01345	COG0396	ATPase activity
ETP70_RS01350	COG0719	Fe-S assembly protein
ETP70_RS01355	COG2166	iron-sulfur cluster assembly
ETP70_RS01360	COG2151	metal-sulfur cluster biosynthetic enzyme
ETP70_RS01365	COG0303	'Molybdopterin
ETP70_RS01385	COG0254	rRNA binding
ETP70_RS01390	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ETP70_RS01395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ETP70_RS01410	COG0436	Aminotransferase
ETP70_RS01415	COG0460	homoserine dehydrogenase
ETP70_RS01425	COG3383	formate dehydrogenase (NAD+) activity
ETP70_RS01430	COG0792	nuclease activity
ETP70_RS01435	COG3437	response regulator, receiver
ETP70_RS01435	COG0784	Response regulator, receiver
ETP70_RS01445	COG1012	belongs to the aldehyde dehydrogenase family
ETP70_RS01480	COG1234	tRNA 3'-trailer cleavage
ETP70_RS01485	COG4716	Myosin-crossreactive antigen
ETP70_RS01495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ETP70_RS01505	COG0424	maF-like protein
ETP70_RS01515	COG0156	8-amino-7-oxononanoate synthase activity
ETP70_RS01520	COG0444	Belongs to the ABC transporter superfamily
ETP70_RS01525	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ETP70_RS01530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ETP70_RS01535	COG0174	glutamine synthetase
ETP70_RS01570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ETP70_RS01575	COG0581	inorganic phosphate transmembrane transporter activity
ETP70_RS01585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ETP70_RS01610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ETP70_RS01610	COG0140	phosphoribosyl-ATP diphosphatase activity
ETP70_RS01625	COG1242	4 iron, 4 sulfur cluster binding
ETP70_RS01630	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ETP70_RS01650	COG1450	Type ii and iii secretion system protein
ETP70_RS01675	COG4962	Type ii secretion system protein e
ETP70_RS01700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ETP70_RS01710	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ETP70_RS01720	COG1222	aaa ATPase
ETP70_RS01725	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ETP70_RS01730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ETP70_RS01735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ETP70_RS01740	COG0649	NAD binding
ETP70_RS01760	COG1034	ATP synthesis coupled electron transport
ETP70_RS01765	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ETP70_RS01770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ETP70_RS01775	COG0839	Belongs to the complex I subunit 6 family
ETP70_RS01780	COG0713	ATP synthesis coupled electron transport
ETP70_RS01785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ETP70_RS01795	COG1007	ATP synthesis coupled electron transport
ETP70_RS01805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ETP70_RS01825	COG0492	ferredoxin-NADP+ reductase activity
ETP70_RS01835	COG3118	belongs to the thioredoxin family
ETP70_RS01845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ETP70_RS01855	COG0826	peptidase U32
ETP70_RS01860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ETP70_RS01880	COG0752	glycyl-tRNA synthetase alpha subunit
ETP70_RS01890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ETP70_RS01930	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ETP70_RS01935	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ETP70_RS01940	COG1671	Belongs to the UPF0178 family
ETP70_RS01950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ETP70_RS01980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ETP70_RS01985	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ETP70_RS01990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ETP70_RS02000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ETP70_RS02015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ETP70_RS02025	COG1519	Transferase
ETP70_RS02030	COG0564	pseudouridine synthase activity
ETP70_RS02035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ETP70_RS02040	COG0228	four-way junction DNA binding
ETP70_RS02050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ETP70_RS02055	COG0336	Belongs to the RNA methyltransferase TrmD family
ETP70_RS02060	COG0335	large ribosomal subunit rRNA binding
ETP70_RS02070	COG0189	ligase activity
ETP70_RS02100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ETP70_RS02105	COG0542	response to heat
ETP70_RS02110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ETP70_RS02155	COG5433	transposase activity
ETP70_RS02185	COG1192	Involved in chromosome partitioning
ETP70_RS02265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ETP70_RS02340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ETP70_RS02375	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ETP70_RS02385	COG1518	maintenance of DNA repeat elements
ETP70_RS02430	COG1337	RAMP superfamily
ETP70_RS02460	COG0305	Participates in initiation and elongation during chromosome replication
ETP70_RS02510	COG0768	penicillin binding
ETP70_RS02560	COG0582	viral genome integration into host DNA
ETP70_RS02625	COG0159	tryptophan synthase activity
ETP70_RS02635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ETP70_RS02640	COG2255	four-way junction helicase activity
ETP70_RS02645	COG0628	permease
ETP70_RS02665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ETP70_RS02670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ETP70_RS02675	COG0745	RESPONSE REGULATOR receiver
ETP70_RS02680	COG2264	protein methyltransferase activity
ETP70_RS02685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ETP70_RS02690	COG0688	phosphatidylethanolamine metabolic process
ETP70_RS02705	COG1181	Belongs to the D-alanine--D-alanine ligase family
ETP70_RS02715	COG1278	Cold shock
ETP70_RS02720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ETP70_RS02730	COG0560	Phosphoserine phosphatase
ETP70_RS02750	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ETP70_RS02755	COG0629	single-stranded DNA binding
ETP70_RS02760	COG0360	Binds together with S18 to 16S ribosomal RNA
ETP70_RS02765	COG3437	response regulator, receiver
ETP70_RS02770	COG5002	protein histidine kinase activity
ETP70_RS02770	COG0784	Response regulator, receiver
ETP70_RS02770	COG2198	Histidine kinase
ETP70_RS02775	COG2861	carbohydrate metabolic process
ETP70_RS02790	COG0439	Biotin carboxylase
ETP70_RS02795	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ETP70_RS02800	COG0805	protein transport
ETP70_RS02805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ETP70_RS02810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ETP70_RS02815	COG0494	nUDIX hydrolase
ETP70_RS02820	COG0527	aspartate kinase activity
ETP70_RS02835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ETP70_RS02840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ETP70_RS02845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ETP70_RS02850	COG0776	regulation of translation
ETP70_RS02890	COG2226	methyltransferase
ETP70_RS02900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ETP70_RS02910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ETP70_RS02935	COG0542	response to heat
ETP70_RS02940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ETP70_RS02945	COG0594	ribonuclease P activity
ETP70_RS02950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ETP70_RS02955	COG0706	membrane insertase activity
ETP70_RS02965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ETP70_RS02970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ETP70_RS02975	COG2200	EAL domain
ETP70_RS02975	COG3287	FIST C domain
ETP70_RS02975	COG2199	diguanylate cyclase activity
ETP70_RS02990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ETP70_RS03000	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ETP70_RS03005	COG0540	Belongs to the ATCase OTCase family
ETP70_RS03010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ETP70_RS03015	COG4191	Histidine kinase
ETP70_RS03030	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ETP70_RS03035	COG0193	aminoacyl-tRNA hydrolase activity
ETP70_RS03045	COG0019	diaminopimelate decarboxylase activity
ETP70_RS03055	COG0077	Prephenate dehydratase
ETP70_RS03055	COG1605	Chorismate mutase
ETP70_RS03060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ETP70_RS03070	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ETP70_RS03080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ETP70_RS03090	COG1959	2 iron, 2 sulfur cluster binding
ETP70_RS03095	COG1496	oxidoreductase activity
ETP70_RS03100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ETP70_RS03105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ETP70_RS03115	COG3787	Belongs to the UPF0306 family
ETP70_RS03130	COG1132	(ABC) transporter
ETP70_RS03135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ETP70_RS03140	COG0204	Acyl-transferase
ETP70_RS03150	COG0047	phosphoribosylformylglycinamidine synthase activity
ETP70_RS03155	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ETP70_RS03160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ETP70_RS03165	COG0793	Belongs to the peptidase S41A family
ETP70_RS03180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ETP70_RS03260	COG0443	Heat shock 70 kDa protein
ETP70_RS03265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ETP70_RS03280	COG0481	GTPase activity
ETP70_RS03285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ETP70_RS03300	COG0557	exoribonuclease II activity
ETP70_RS03315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ETP70_RS03320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ETP70_RS03330	COG0205	6-phosphofructokinase activity
ETP70_RS03335	COG0138	bifunctional purine biosynthesis protein purh
ETP70_RS03345	COG0484	heat shock protein binding
ETP70_RS03355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ETP70_RS03380	COG0742	ribosomal rna small subunit methyltransferase
ETP70_RS03385	COG1706	bacterial-type flagellum-dependent cell motility
ETP70_RS03390	COG3951	Flagellar rod assembly protein muramidase FlgJ
ETP70_RS03405	COG1256	bacterial-type flagellum assembly
ETP70_RS03405	COG4786	Flagellar basal body rod
ETP70_RS03410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ETP70_RS03415	COG0628	permease
ETP70_RS03420	COG0512	Glutamine amidotransferase of anthranilate synthase
ETP70_RS03475	COG0339	signal peptide processing
ETP70_RS03480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ETP70_RS03490	COG0631	protein serine/threonine phosphatase activity
ETP70_RS03495	COG2116	formate transmembrane transporter activity
ETP70_RS03500	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ETP70_RS03505	COG2223	nitrite transmembrane transporter activity
ETP70_RS03530	COG1140	nitrate reductase beta subunit
ETP70_RS03535	COG0243	molybdopterin cofactor binding
ETP70_RS03545	COG0528	UMP kinase activity
ETP70_RS03550	COG1758	RNA polymerase activity
ETP70_RS03560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ETP70_RS03570	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETP70_RS03575	COG2404	hydrolase activity, acting on ester bonds
ETP70_RS03580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ETP70_RS03590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ETP70_RS03595	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ETP70_RS03600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ETP70_RS03605	COG0727	PFAM Uncharacterised protein family (UPF0153)
ETP70_RS03615	COG0134	indole-3-glycerol-phosphate synthase activity
ETP70_RS03625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ETP70_RS03635	COG0251	oxidation-reduction process
ETP70_RS03640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ETP70_RS03645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ETP70_RS03650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ETP70_RS03655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ETP70_RS03660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ETP70_RS03670	COG1192	Involved in chromosome partitioning
ETP70_RS03675	COG1475	DNA binding
ETP70_RS03690	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ETP70_RS03695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ETP70_RS03700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ETP70_RS03705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ETP70_RS03710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ETP70_RS03715	COG0811	peptide transport
ETP70_RS03720	COG0848	biopolymer transport protein
ETP70_RS03730	COG0823	Involved in the tonB-independent uptake of proteins
ETP70_RS03745	COG1047	Peptidyl-prolyl cis-trans
ETP70_RS03750	COG2204	response regulator
ETP70_RS03755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ETP70_RS03760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ETP70_RS03760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ETP70_RS03765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ETP70_RS03770	COG0037	tRNA processing
ETP70_RS03790	COG3287	FIST C domain
ETP70_RS03790	COG2200	EAL domain
ETP70_RS03790	COG2199	diguanylate cyclase activity
ETP70_RS03795	COG0517	IMP dehydrogenase activity
ETP70_RS03795	COG0516	GMP reductase activity
ETP70_RS03810	COG0154	amidase activity
ETP70_RS03815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ETP70_RS03820	COG1058	Belongs to the CinA family
ETP70_RS03820	COG1546	Belongs to the CinA family
ETP70_RS03860	COG1132	(ABC) transporter
ETP70_RS03865	COG0772	Belongs to the SEDS family
ETP70_RS03870	COG0564	pseudouridine synthase activity
ETP70_RS03880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ETP70_RS03885	COG2884	Cell division ATP-binding protein ftsE
ETP70_RS03900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ETP70_RS03910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ETP70_RS03915	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ETP70_RS03935	COG2151	metal-sulfur cluster biosynthetic enzyme
ETP70_RS03950	COG1522	sequence-specific DNA binding
ETP70_RS03955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ETP70_RS03955	COG1648	precorrin-2 dehydrogenase activity
ETP70_RS03965	COG1858	cytochrome C peroxidase
ETP70_RS03980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ETP70_RS04000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ETP70_RS04000	COG1648	precorrin-2 dehydrogenase activity
ETP70_RS04010	COG0535	radical SAM domain protein
ETP70_RS04025	COG3256	nitric oxide reductase
ETP70_RS04040	COG0745	RESPONSE REGULATOR receiver
ETP70_RS04045	COG0275	rRNA processing
ETP70_RS04070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ETP70_RS04080	COG1722	exodeoxyribonuclease VII activity
ETP70_RS04085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ETP70_RS04100	COG0217	transcriptional regulatory protein
ETP70_RS04105	COG1739	Uncharacterized protein family UPF0029
ETP70_RS04115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ETP70_RS04135	COG4796	Type ii and iii secretion system protein
ETP70_RS04170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ETP70_RS04175	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ETP70_RS04180	COG0359	binds to the 23S rRNA
ETP70_RS04190	COG0137	argininosuccinate synthase activity
ETP70_RS04220	COG0408	coproporphyrinogen oxidase activity
ETP70_RS04230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ETP70_RS04235	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ETP70_RS04240	COG0196	riboflavin kinase activity
ETP70_RS04245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ETP70_RS04245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ETP70_RS04255	COG1796	DNA polymerase
ETP70_RS04255	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ETP70_RS04260	COG0585	pseudouridine synthase activity
ETP70_RS04275	COG0500	methyltransferase
ETP70_RS04280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ETP70_RS04280	COG2050	protein possibly involved in aromatic compounds catabolism
ETP70_RS04295	COG2833	Protein of unknown function (DUF455)
ETP70_RS04310	COG3437	response regulator, receiver
ETP70_RS04310	COG0784	Response regulator, receiver
ETP70_RS04315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ETP70_RS04320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ETP70_RS04325	COG1663	tetraacyldisaccharide 4'-kinase activity
ETP70_RS04330	COG0531	amino acid
ETP70_RS04340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ETP70_RS04355	COG0142	geranyltranstransferase activity
ETP70_RS04360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ETP70_RS04365	COG0442	prolyl-tRNA aminoacylation
ETP70_RS04370	COG3030	protein affecting phage T7 exclusion by the F plasmid
ETP70_RS04380	COG0181	hydroxymethylbilane synthase activity
ETP70_RS04385	COG0754	glutathionylspermidine amidase activity
ETP70_RS04405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ETP70_RS04420	COG1077	Cell shape determining protein MreB Mrl
ETP70_RS04425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ETP70_RS04430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ETP70_RS04435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ETP70_RS04440	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ETP70_RS04445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ETP70_RS04450	COG0642	Histidine kinase
ETP70_RS04455	COG0745	RESPONSE REGULATOR receiver
ETP70_RS04470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETP70_RS04480	COG2176	DNA-directed DNA polymerase activity
ETP70_RS04485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ETP70_RS04490	COG0284	orotidine-5'-phosphate decarboxylase activity
ETP70_RS04515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ETP70_RS04520	COG1610	YqeY-like protein
ETP70_RS04525	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ETP70_RS04540	COG0659	secondary active sulfate transmembrane transporter activity
ETP70_RS04545	COG0525	valine-tRNA ligase activity
ETP70_RS04550	COG3706	GGDEF domain
ETP70_RS04575	COG1704	LemA family
ETP70_RS04580	COG2081	HI0933 family
ETP70_RS04585	COG1193	negative regulation of DNA recombination
ETP70_RS04605	COG0436	Aminotransferase
ETP70_RS04620	COG0736	holo-[acyl-carrier-protein] synthase activity
ETP70_RS04625	COG1580	Controls the rotational direction of flagella during chemotaxis
ETP70_RS04635	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ETP70_RS04650	COG0552	protein localization to endoplasmic reticulum
ETP70_RS04665	COG1418	mRNA catabolic process
ETP70_RS04675	COG0356	it plays a direct role in the translocation of protons across the membrane
ETP70_RS04685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ETP70_RS04690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ETP70_RS04700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ETP70_RS04705	COG0471	metal ion transport
ETP70_RS04725	COG0501	Belongs to the peptidase M48B family
ETP70_RS04730	COG2890	protein-(glutamine-N5) methyltransferase activity
ETP70_RS04755	COG1136	(ABC) transporter
ETP70_RS04765	COG0484	heat shock protein binding
ETP70_RS04770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ETP70_RS04775	COG0849	cell division
ETP70_RS04785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ETP70_RS04795	COG0484	heat shock protein binding
ETP70_RS04800	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ETP70_RS04805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ETP70_RS04815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ETP70_RS04820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ETP70_RS04835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ETP70_RS04840	COG1592	Rubrerythrin
ETP70_RS04850	COG0714	Associated with various cellular activities
ETP70_RS04895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ETP70_RS04900	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ETP70_RS04920	COG1331	Highly conserved protein containing a thioredoxin domain
ETP70_RS04930	COG4191	Histidine kinase
ETP70_RS04940	COG4232	protein-disulfide reductase activity
ETP70_RS04955	COG0642	Histidine kinase
ETP70_RS04975	COG3258	Cytochrome c
ETP70_RS04980	COG0737	Belongs to the 5'-nucleotidase family
ETP70_RS05010	COG0513	Belongs to the DEAD box helicase family
ETP70_RS05020	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ETP70_RS05025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ETP70_RS05030	COG0343	queuine tRNA-ribosyltransferase activity
ETP70_RS05045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ETP70_RS05055	COG0587	DNA-directed DNA polymerase activity
ETP70_RS05060	COG1362	aminopeptidase activity
ETP70_RS05065	COG0642	Histidine kinase
ETP70_RS05070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ETP70_RS05070	COG1333	cytochrome c biogenesis protein
ETP70_RS05085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ETP70_RS05110	COG0840	transmembrane signaling receptor activity
ETP70_RS05175	COG1730	sister chromatid segregation
ETP70_RS05220	COG0500	methyltransferase
ETP70_RS05235	COG0069	glutamate synthase activity
ETP70_RS05235	COG0070	glutamate synthase
ETP70_RS05235	COG0067	glutamate synthase
ETP70_RS05240	COG0493	'glutamate synthase
ETP70_RS05245	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ETP70_RS05255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ETP70_RS05270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ETP70_RS05285	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ETP70_RS05295	COG0730	response to heat
ETP70_RS05300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ETP70_RS05305	COG5001	Diguanylate cyclase
ETP70_RS05305	COG3300	MHYT domain
ETP70_RS05310	COG0840	transmembrane signaling receptor activity
ETP70_RS05315	COG2201	protein-glutamate methylesterase activity
ETP70_RS05320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ETP70_RS05340	COG1227	inorganic diphosphatase activity
ETP70_RS05365	COG0784	Response regulator, receiver
ETP70_RS05365	COG2198	Histidine kinase
ETP70_RS05365	COG2205	protein histidine kinase activity
ETP70_RS05365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ETP70_RS05370	COG0745	RESPONSE REGULATOR receiver
ETP70_RS05375	COG1032	radical SAM domain protein
ETP70_RS05390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ETP70_RS05395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ETP70_RS05400	COG0802	atpase or kinase
ETP70_RS05405	COG1137	ATPase activity
ETP70_RS05410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ETP70_RS05440	COG3150	esterase
ETP70_RS05445	COG2165	general secretion pathway protein
ETP70_RS05455	COG1459	type II secretion system
ETP70_RS05485	COG1450	Type ii and iii secretion system protein
ETP70_RS05490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ETP70_RS05510	COG2361	Protein of unknown function DUF86
ETP70_RS05530	COG1832	CoA-binding protein
ETP70_RS05535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ETP70_RS05545	COG0028	Belongs to the TPP enzyme family
ETP70_RS05550	COG0440	acetolactate synthase activity
ETP70_RS05555	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ETP70_RS05570	COG1045	serine acetyltransferase
ETP70_RS05575	COG1166	arginine decarboxylase activity
ETP70_RS05580	COG0069	glutamate synthase activity
ETP70_RS05585	COG0124	histidyl-tRNA synthetase
ETP70_RS05590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ETP70_RS05595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ETP70_RS05600	COG0163	prenyltransferase activity
ETP70_RS05615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ETP70_RS05620	COG1674	ftsk spoiiie
ETP70_RS05620	COG1196	nuclear chromosome segregation
ETP70_RS05630	COG1049	propionate catabolic process, 2-methylcitrate cycle
ETP70_RS05640	COG0653	protein targeting
ETP70_RS05645	COG4591	ABC-type transport system involved in lipoprotein release permease component
ETP70_RS05665	COG0039	L-malate dehydrogenase activity
ETP70_RS05670	COG0114	fumarate hydratase activity
ETP70_RS05675	COG0045	succinate-CoA ligase (ADP-forming) activity
ETP70_RS05680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ETP70_RS05690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ETP70_RS05690	COG0674	pyruvate-flavodoxin oxidoreductase activity
ETP70_RS05705	COG1309	transcriptional regulator
ETP70_RS05730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ETP70_RS05735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ETP70_RS05750	COG1763	Mo-molybdopterin cofactor biosynthetic process
ETP70_RS05755	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ETP70_RS05765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETP70_RS05765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETP70_RS05780	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ETP70_RS05785	COG0745	RESPONSE REGULATOR receiver
ETP70_RS05795	COG5002	protein histidine kinase activity
ETP70_RS05795	COG5001	Diguanylate cyclase
ETP70_RS05810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ETP70_RS05820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ETP70_RS05845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ETP70_RS05860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ETP70_RS05865	COG0131	Imidazoleglycerol-phosphate dehydratase
ETP70_RS05870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ETP70_RS05880	COG0084	hydrolase, TatD family'
ETP70_RS05885	COG0497	DNA recombination
ETP70_RS06020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETP70_RS06030	COG2703	oxygen carrier activity
ETP70_RS06055	COG0492	ferredoxin-NADP+ reductase activity
ETP70_RS06075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ETP70_RS06080	COG2703	oxygen carrier activity
ETP70_RS06110	COG1355	regulation of microtubule-based process
ETP70_RS06125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ETP70_RS06130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ETP70_RS06135	COG0563	adenylate kinase activity
ETP70_RS06140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ETP70_RS06140	COG0301	tRNA thio-modification
ETP70_RS06145	COG0563	adenylate kinase activity
ETP70_RS06170	COG0666	response to abiotic stimulus
ETP70_RS06175	COG2171	N-acyltransferase activity
ETP70_RS06205	COG0788	formyltetrahydrofolate deformylase activity
ETP70_RS06220	COG0473	3-isopropylmalate dehydrogenase activity
ETP70_RS06225	COG0066	3-isopropylmalate dehydratase activity
ETP70_RS06230	COG4786	Flagellar basal body rod
ETP70_RS06235	COG4786	Flagellar basal body rod
ETP70_RS06240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ETP70_RS06260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ETP70_RS06280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ETP70_RS06285	COG0681	Belongs to the peptidase S26 family
ETP70_RS06290	COG1994	Peptidase M50
ETP70_RS06295	COG0698	ribose 5-phosphate isomerase
ETP70_RS06305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ETP70_RS06310	COG0133	tryptophan synthase activity
ETP70_RS06315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ETP70_RS06325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ETP70_RS06335	COG0012	GTP binding
ETP70_RS06370	COG3043	anaerobic respiration
ETP70_RS06375	COG0348	domain, Protein
ETP70_RS06380	COG0437	4 iron, 4 sulfur cluster binding
ETP70_RS06385	COG0243	molybdopterin cofactor binding
ETP70_RS06395	COG0585	pseudouridine synthase activity
ETP70_RS06400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ETP70_RS06415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ETP70_RS06420	COG2048	Heterodisulfide reductase, subunit B
ETP70_RS06425	COG2703	oxygen carrier activity
ETP70_RS06430	COG0708	Exodeoxyribonuclease III
ETP70_RS06440	COG0521	Mo-molybdopterin cofactor biosynthetic process
ETP70_RS06450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ETP70_RS06455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ETP70_RS06465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ETP70_RS06475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ETP70_RS06480	COG1338	Plays a role in the flagellum-specific transport system
ETP70_RS06490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ETP70_RS06505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ETP70_RS06540	COG0210	DNA helicase
ETP70_RS06565	COG1944	ATP diphosphatase activity
ETP70_RS06570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ETP70_RS06575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ETP70_RS06580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ETP70_RS06585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ETP70_RS06590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ETP70_RS06600	COG0101	tRNA pseudouridine synthase activity
ETP70_RS06605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ETP70_RS06620	COG1773	rubredoxin
ETP70_RS06625	COG0822	iron-sulfur transferase activity
ETP70_RS06640	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ETP70_RS06645	COG1073	alpha beta
ETP70_RS06690	COG2199	diguanylate cyclase activity
ETP70_RS06690	COG3287	FIST C domain
ETP70_RS06690	COG2200	EAL domain
ETP70_RS06695	COG1573	uracil-dna glycosylase
ETP70_RS06710	COG0824	Thioesterase
ETP70_RS06715	COG0582	viral genome integration into host DNA
ETP70_RS06740	COG3328	transposase activity
ETP70_RS06785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ETP70_RS06910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ETP70_RS06985	COG0842	Transport permease protein
ETP70_RS06990	COG0842	Transport permease protein
ETP70_RS06995	COG0842	Transport permease protein
ETP70_RS06995	COG1129	ABC transporter
ETP70_RS07020	COG1309	transcriptional regulator
ETP70_RS07025	COG3706	GGDEF domain
ETP70_RS07050	COG0531	amino acid
ETP70_RS07055	COG1331	Highly conserved protein containing a thioredoxin domain
ETP70_RS07060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ETP70_RS07065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ETP70_RS07115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ETP70_RS07130	COG1342	Belongs to the UPF0251 family
ETP70_RS07150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ETP70_RS07170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ETP70_RS07175	COG0750	zinc metalloprotease
ETP70_RS07240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ETP70_RS07255	COG2081	HI0933 family
ETP70_RS07265	COG0375	protein maturation
ETP70_RS07270	COG1024	Enoyl-CoA hydratase
ETP70_RS07270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ETP70_RS07280	COG0501	Belongs to the peptidase M48B family
ETP70_RS07285	COG0309	Hydrogenase expression formation protein (HypE)
ETP70_RS07290	COG0409	Hydrogenase expression formation protein
ETP70_RS07295	COG0298	carbon dioxide binding
ETP70_RS07300	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ETP70_RS07325	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ETP70_RS07340	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ETP70_RS07345	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ETP70_RS07350	COG3259	Nickel-dependent hydrogenase
ETP70_RS07365	COG0352	thiamine-phosphate diphosphorylase activity
ETP70_RS07395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ETP70_RS07400	COG5001	Diguanylate cyclase
ETP70_RS07400	COG3300	MHYT domain
ETP70_RS07405	COG0667	Aldo Keto reductase
ETP70_RS07410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ETP70_RS07410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ETP70_RS07420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ETP70_RS07460	COG4974	Belongs to the 'phage' integrase family
ETP70_RS07475	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ETP70_RS07480	COG1393	Belongs to the ArsC family
ETP70_RS07500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ETP70_RS07505	COG0243	molybdopterin cofactor binding
ETP70_RS07515	COG0784	Response regulator, receiver
ETP70_RS07515	COG0835	chemotaxis
ETP70_RS07535	COG2199	diguanylate cyclase activity
ETP70_RS07535	COG2200	EAL domain
ETP70_RS07535	COG3287	FIST C domain
ETP70_RS07545	COG0840	transmembrane signaling receptor activity
ETP70_RS07560	COG0511	ligase activity, forming carbon-carbon bonds
ETP70_RS07560	COG5016	pyruvate
ETP70_RS07580	COG0326	Molecular chaperone. Has ATPase activity
ETP70_RS07600	COG0488	(ABC) transporter
ETP70_RS07605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ETP70_RS07615	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ETP70_RS07620	COG3706	GGDEF domain
ETP70_RS07635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ETP70_RS07650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ETP70_RS07655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ETP70_RS07660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ETP70_RS07700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ETP70_RS07710	COG1181	Belongs to the D-alanine--D-alanine ligase family
ETP70_RS07715	COG0632	four-way junction helicase activity
ETP70_RS07725	COG0728	peptidoglycan biosynthetic process
ETP70_RS07730	COG0215	cysteine-tRNA ligase activity
ETP70_RS07735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ETP70_RS07750	COG1271	oxidase subunit
ETP70_RS07755	COG1294	oxidase, subunit
ETP70_RS07760	COG3437	response regulator, receiver
ETP70_RS07760	COG0784	Response regulator, receiver
ETP70_RS07790	COG3300	MHYT domain
ETP70_RS07790	COG5001	Diguanylate cyclase
ETP70_RS07795	COG0167	dihydroorotate dehydrogenase activity
ETP70_RS07800	COG0612	Peptidase, M16
ETP70_RS07805	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ETP70_RS07825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ETP70_RS07830	COG1028	Short-chain dehydrogenase reductase Sdr
ETP70_RS07835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ETP70_RS07845	COG0539	negative regulation of cytoplasmic translation
ETP70_RS07845	COG1185	polyribonucleotide nucleotidyltransferase activity
ETP70_RS07850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ETP70_RS07855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ETP70_RS07860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETP70_RS07860	COG0072	phenylalanine-tRNA ligase activity
ETP70_RS07865	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ETP70_RS07870	COG0537	adenosine 5'-monophosphoramidase activity
ETP70_RS07880	COG0165	Argininosuccinate lyase
ETP70_RS07890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ETP70_RS07910	COG1287	oligosaccharyl transferase activity
ETP70_RS07920	COG1086	Polysaccharide biosynthesis protein
ETP70_RS07930	COG1793	dna ligase
ETP70_RS07950	COG0463	Glycosyl transferase, family 2
ETP70_RS07955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ETP70_RS07970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ETP70_RS07995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ETP70_RS08000	COG0500	methyltransferase
ETP70_RS08005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ETP70_RS08025	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ETP70_RS08035	COG3836	Belongs to the HpcH HpaI aldolase family
ETP70_RS08055	COG2089	acid synthase
ETP70_RS08070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ETP70_RS08075	COG3980	spore coat polysaccharide biosynthesis protein
ETP70_RS08090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ETP70_RS08095	COG1086	Polysaccharide biosynthesis protein
ETP70_RS08105	COG1555	photosystem II stabilization
ETP70_RS08125	COG1216	Glycosyl transferase, family 2
ETP70_RS08135	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ETP70_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
ETP70_RS08150	COG3347	Dehydrogenase
ETP70_RS08160	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ETP70_RS08175	COG0489	protein tyrosine kinase activity
ETP70_RS08180	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ETP70_RS08185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ETP70_RS08185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ETP70_RS08190	COG0745	RESPONSE REGULATOR receiver
ETP70_RS08195	COG2046	Belongs to the sulfate adenylyltransferase family
ETP70_RS08205	COG4895	conserved protein (DUF2196)
ETP70_RS08210	COG0668	transmembrane transport
ETP70_RS08215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ETP70_RS08245	COG2501	S4 domain
ETP70_RS08250	COG2827	Endonuclease containing a URI domain
ETP70_RS08255	COG0745	RESPONSE REGULATOR receiver
ETP70_RS08260	COG0784	Response regulator, receiver
ETP70_RS08260	COG2205	protein histidine kinase activity
ETP70_RS08260	COG5002	protein histidine kinase activity
ETP70_RS08275	COG0308	aminopeptidase N
ETP70_RS08280	COG3287	FIST C domain
ETP70_RS08280	COG2199	diguanylate cyclase activity
ETP70_RS08280	COG2200	EAL domain
ETP70_RS08285	COG0513	Belongs to the DEAD box helicase family
ETP70_RS08290	COG2199	diguanylate cyclase activity
ETP70_RS08290	COG2200	EAL domain
ETP70_RS08290	COG3287	FIST C domain
ETP70_RS08300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ETP70_RS08305	COG0247	lactate metabolic process
ETP70_RS08310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ETP70_RS08345	COG0438	transferase activity, transferring glycosyl groups
ETP70_RS08365	COG0859	PFAM glycosyl transferase family 9
ETP70_RS08385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ETP70_RS08385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ETP70_RS08390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ETP70_RS08395	COG2863	cytochrome
ETP70_RS08405	COG2217	Heavy metal translocating P-type atpase
ETP70_RS08420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ETP70_RS08445	COG0482	sulfurtransferase activity
ETP70_RS08455	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ETP70_RS08470	COG0455	bacterial-type flagellum organization
ETP70_RS08475	COG1419	protein localization to endoplasmic reticulum
ETP70_RS08480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ETP70_RS08485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ETP70_RS08490	COG0402	S-adenosylhomocysteine deaminase activity
ETP70_RS08495	COG0616	signal peptide processing
ETP70_RS08505	COG1570	exodeoxyribonuclease VII activity
ETP70_RS08520	COG2226	methyltransferase
ETP70_RS08525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ETP70_RS08525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ETP70_RS08530	COG0779	Required for maturation of 30S ribosomal subunits
ETP70_RS08535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ETP70_RS08540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ETP70_RS08550	COG0083	homoserine kinase activity
ETP70_RS08560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ETP70_RS08575	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ETP70_RS08580	COG0157	Belongs to the NadC ModD family
ETP70_RS08590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ETP70_RS08600	COG0745	RESPONSE REGULATOR receiver
ETP70_RS08605	COG0642	Histidine kinase
ETP70_RS08610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ETP70_RS08620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ETP70_RS08625	COG0287	Prephenate dehydrogenase
ETP70_RS08635	COG2304	oxidoreductase activity
ETP70_RS08655	COG0714	Associated with various cellular activities
ETP70_RS08685	COG1773	rubredoxin
ETP70_RS08695	COG0004	ammonium transporteR
ETP70_RS08705	COG0004	ammonium transporteR
ETP70_RS08720	COG2204	response regulator
ETP70_RS08725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ETP70_RS08735	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ETP70_RS08740	COG0731	radical SAM domain protein
ETP70_RS08745	COG1283	sodium-dependent phosphate transmembrane transporter activity
ETP70_RS08765	COG0406	alpha-ribazole phosphatase activity
ETP70_RS08780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ETP70_RS08785	COG0459	protein refolding
ETP70_RS08805	COG0848	biopolymer transport protein
ETP70_RS08810	COG0811	peptide transport
ETP70_RS08815	COG0642	Histidine kinase
ETP70_RS08820	COG0745	RESPONSE REGULATOR receiver
ETP70_RS08825	COG0418	dihydroorotase activity
ETP70_RS08835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ETP70_RS08845	COG1278	Cold shock
ETP70_RS08850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ETP70_RS08855	COG0280	phosphate acetyltransferase
ETP70_RS08855	COG0857	belongs to the CobB CobQ family
ETP70_RS08880	COG3706	GGDEF domain
ETP70_RS08885	COG0488	(ABC) transporter
ETP70_RS08905	COG5001	Diguanylate cyclase
ETP70_RS08905	COG4251	negative regulation of phosphorylation
ETP70_RS08905	COG2203	Gaf domain
ETP70_RS08905	COG3706	GGDEF domain
ETP70_RS08915	COG0006	proline dipeptidase activity
ETP70_RS08925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ETP70_RS08925	COG3008	intermembrane lipid transfer
ETP70_RS08930	COG1127	ABC transporter
ETP70_RS08935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ETP70_RS08940	COG0835	chemotaxis
ETP70_RS08945	COG0643	Histidine kinase
ETP70_RS08945	COG2198	Histidine kinase
ETP70_RS08945	COG0784	Response regulator, receiver
ETP70_RS08950	COG0784	Response regulator, receiver
ETP70_RS08950	COG0835	chemotaxis
ETP70_RS08960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ETP70_RS08965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ETP70_RS08975	COG0840	transmembrane signaling receptor activity
ETP70_RS08995	COG0745	RESPONSE REGULATOR receiver
ETP70_RS09000	COG0642	Histidine kinase
ETP70_RS09045	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ETP70_RS09050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ETP70_RS09060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ETP70_RS09070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ETP70_RS09075	COG1365	unkown
ETP70_RS09085	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ETP70_RS09090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ETP70_RS09135	COG0745	RESPONSE REGULATOR receiver
ETP70_RS09145	COG1692	metallophosphoesterase
ETP70_RS09155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ETP70_RS09160	COG1238	metal cluster binding
ETP70_RS09165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ETP70_RS09175	COG0739	heme binding
ETP70_RS09180	COG0285	dihydrofolate synthase activity
ETP70_RS09195	COG0495	leucyl-tRNA aminoacylation
ETP70_RS09205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ETP70_RS09210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ETP70_RS09215	COG1862	Preprotein translocase
ETP70_RS09220	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ETP70_RS09225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ETP70_RS09230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ETP70_RS09235	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ETP70_RS09240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ETP70_RS09245	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ETP70_RS09260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ETP70_RS09265	COG0135	phosphoribosylanthranilate isomerase activity
ETP70_RS09270	COG2176	DNA-directed DNA polymerase activity
ETP70_RS09275	COG0825	malonyl-CoA metabolic process
ETP70_RS09280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ETP70_RS09285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ETP70_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
ETP70_RS09295	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ETP70_RS09300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ETP70_RS09305	COG0788	formyltetrahydrofolate deformylase activity
ETP70_RS09315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ETP70_RS09340	COG0589	response to stress
ETP70_RS09350	COG1320	monovalent cation:proton antiporter activity
ETP70_RS09360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ETP70_RS09360	COG2111	Na H antiporter
ETP70_RS09375	COG0651	ATP synthesis coupled electron transport
ETP70_RS09380	COG0651	ATP synthesis coupled electron transport
ETP70_RS09405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ETP70_RS09415	COG0556	nucleotide-excision repair
ETP70_RS09425	COG2081	HI0933 family
ETP70_RS09430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ETP70_RS09435	COG0037	tRNA processing
ETP70_RS09455	COG4974	Belongs to the 'phage' integrase family
ETP70_RS09465	COG2121	Domain of unknown function (DUF374)
ETP70_RS09470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ETP70_RS09480	COG0195	Participates in both transcription termination and antitermination
ETP70_RS09485	COG0601	transmembrane transport
ETP70_RS09500	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ETP70_RS09505	COG0149	triose-phosphate isomerase activity
ETP70_RS09510	COG0126	phosphoglycerate kinase activity
ETP70_RS09520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ETP70_RS09530	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ETP70_RS09535	COG0642	Histidine kinase
ETP70_RS09540	COG0745	RESPONSE REGULATOR receiver
ETP70_RS09545	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ETP70_RS09550	COG1918	ferrous iron import across plasma membrane
ETP70_RS09560	COG1183	phosphatidylcholine synthase activity
ETP70_RS09575	COG1322	Protein conserved in bacteria
ETP70_RS09580	COG0513	Belongs to the DEAD box helicase family
ETP70_RS09630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ETP70_RS09635	COG0416	fatty acid biosynthetic process
ETP70_RS09640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ETP70_RS09650	COG0105	UTP biosynthetic process
ETP70_RS09660	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ETP70_RS09665	COG3228	Belongs to the MtfA family
ETP70_RS09675	COG0588	phosphoglycerate mutase activity
ETP70_RS09680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ETP70_RS09685	COG0321	lipoyl(octanoyl) transferase activity
ETP70_RS09690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ETP70_RS09695	COG0508	dehydrogenase complex catalyzes the overall conversion of
ETP70_RS09700	COG0022	dehydrogenase e1 component
ETP70_RS09700	COG0508	dehydrogenase complex catalyzes the overall conversion of
ETP70_RS09705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ETP70_RS09720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ETP70_RS09725	COG1830	Aldolase
ETP70_RS09730	COG0574	Belongs to the PEP-utilizing enzyme family
ETP70_RS09730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ETP70_RS09740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ETP70_RS09830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ETP70_RS09850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ETP70_RS09860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ETP70_RS09870	COG0450	alkyl hydroperoxide reductase
ETP70_RS09875	COG3706	GGDEF domain
ETP70_RS09910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ETP70_RS09935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ETP70_RS09940	COG3706	GGDEF domain
ETP70_RS09945	COG4948	Mandelate Racemase Muconate Lactonizing
ETP70_RS09985	COG3002	Belongs to the UPF0753 family
ETP70_RS09995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ETP70_RS10020	COG1013	pyruvate-flavodoxin oxidoreductase activity
ETP70_RS10040	COG0674	pyruvate-flavodoxin oxidoreductase activity
ETP70_RS10045	COG0674	pyruvate-flavodoxin oxidoreductase activity
ETP70_RS10045	COG1013	pyruvate-flavodoxin oxidoreductase activity
ETP70_RS10045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ETP70_RS10045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ETP70_RS10060	COG0544	peptidyl-prolyl cis-trans isomerase activity
ETP70_RS10110	COG1757	Na H antiporter
ETP70_RS10125	COG0018	arginyl-trna synthetase
ETP70_RS10130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ETP70_RS10135	COG0194	GDP metabolic process
ETP70_RS10150	COG1136	(ABC) transporter
ETP70_RS10155	COG1252	NADH dehydrogenase
ETP70_RS10160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ETP70_RS10165	COG0052	Belongs to the universal ribosomal protein uS2 family
ETP70_RS10175	COG3287	FIST C domain
ETP70_RS10175	COG2200	EAL domain
ETP70_RS10175	COG2199	diguanylate cyclase activity
ETP70_RS10195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ETP70_RS10205	COG0586	Pfam SNARE associated Golgi protein
ETP70_RS10210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ETP70_RS10215	COG0772	Belongs to the SEDS family
ETP70_RS10245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ETP70_RS10255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ETP70_RS10265	COG0647	UMP catabolic process
ETP70_RS10275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ETP70_RS10280	COG0612	Peptidase, M16
ETP70_RS10285	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ETP70_RS10300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ETP70_RS10305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ETP70_RS10340	COG1160	GTP binding
ETP70_RS10345	COG1981	membrane
ETP70_RS10370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ETP70_RS10375	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ETP70_RS10380	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ETP70_RS10385	COG0113	porphobilinogen synthase activity
ETP70_RS10390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ETP70_RS10405	COG0357	Ribosomal RNA small subunit methyltransferase G
ETP70_RS10420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ETP70_RS10440	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ETP70_RS10455	COG0305	Participates in initiation and elongation during chromosome replication
ETP70_RS10465	COG1295	ribonuclease BN
ETP70_RS10470	COG0277	FAD linked oxidase domain protein
ETP70_RS10480	COG0739	heme binding
ETP70_RS10485	COG0494	nUDIX hydrolase
ETP70_RS10490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ETP70_RS10495	COG4969	Belongs to the N-Me-Phe pilin family
ETP70_RS10510	COG1815	bacterial-type flagellum-dependent cell motility
ETP70_RS10530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ETP70_RS10535	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ETP70_RS10555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ETP70_RS10560	COG0049	tRNA binding
ETP70_RS10565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ETP70_RS10570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ETP70_RS10575	COG0085	RNA polymerase activity
ETP70_RS10580	COG0222	ribosome binding
ETP70_RS10585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ETP70_RS10590	COG0081	regulation of translation
ETP70_RS10595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ETP70_RS10600	COG0250	Participates in transcription elongation, termination and antitermination
ETP70_RS10615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ETP70_RS10620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ETP70_RS10650	COG3022	response to hydroperoxide
ETP70_RS10655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ETP70_RS10665	COG0840	transmembrane signaling receptor activity
ETP70_RS10700	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ETP70_RS10710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ETP70_RS10755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ETP70_RS10780	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
ETP70_RS10800	COG3549	Plasmid maintenance system killer
ETP70_RS10805	COG3093	addiction module antidote protein HigA
ETP70_RS10845	COG0438	transferase activity, transferring glycosyl groups
ETP70_RS10905	COG5001	Diguanylate cyclase
ETP70_RS10905	COG3300	MHYT domain
ETP70_RS10910	COG3706	GGDEF domain
ETP70_RS10910	COG2203	Gaf domain
ETP70_RS10910	COG5001	Diguanylate cyclase
ETP70_RS10910	COG4251	negative regulation of phosphorylation
ETP70_RS10915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ETP70_RS10920	COG0142	geranyltranstransferase activity
ETP70_RS10930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ETP70_RS10935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ETP70_RS10945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ETP70_RS10965	COG0203	ribosomal protein L17
ETP70_RS10970	COG0202	RNA polymerase activity
ETP70_RS10975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ETP70_RS10980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ETP70_RS10985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ETP70_RS10990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ETP70_RS10995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ETP70_RS10995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ETP70_RS11025	COG0778	Nitroreductase
ETP70_RS11035	COG0709	Synthesizes selenophosphate from selenide and ATP
ETP70_RS11040	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
ETP70_RS11095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ETP70_RS11115	COG0051	transcription antitermination factor activity, RNA binding
ETP70_RS11120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ETP70_RS11125	COG0088	Forms part of the polypeptide exit tunnel
ETP70_RS11130	COG0089	rRNA binding
ETP70_RS11135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ETP70_RS11140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ETP70_RS11145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ETP70_RS11150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ETP70_RS11155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ETP70_RS11160	COG0255	Belongs to the universal ribosomal protein uL29 family
ETP70_RS11165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ETP70_RS11170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ETP70_RS11175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ETP70_RS11180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ETP70_RS11185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ETP70_RS11190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ETP70_RS11195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ETP70_RS11200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ETP70_RS11205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ETP70_RS11210	COG0200	Binds to the 23S rRNA
ETP70_RS11215	COG0201	protein transport
ETP70_RS11220	COG0024	Methionine aminopeptidase
ETP70_RS11225	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ETP70_RS11270	COG0314	molybdopterin synthase activity
ETP70_RS11280	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ETP70_RS11290	COG0281	malic enzyme
ETP70_RS11310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ETP70_RS11315	COG1187	pseudouridine synthase activity
ETP70_RS11320	COG0517	IMP dehydrogenase activity
ETP70_RS11320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ETP70_RS11330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ETP70_RS11330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ETP70_RS11335	COG2022	thiamine diphosphate biosynthetic process
ETP70_RS11345	COG0733	neurotransmitter:sodium symporter activity
ETP70_RS11375	COG4974	Belongs to the 'phage' integrase family
ETP70_RS11400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ETP70_RS11475	COG1017	nitric oxide dioxygenase activity
ETP70_RS11495	COG4221	oxidoreductase activity
ETP70_RS11510	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ETP70_RS11515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ETP70_RS11520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ETP70_RS11520	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ETP70_RS11550	COG0529	Catalyzes the synthesis of activated sulfate
ETP70_RS11555	COG2895	sulfate adenylyltransferase (ATP) activity
ETP70_RS11560	COG0175	sulfate reduction
ETP70_RS11580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ETP70_RS11585	COG1083	cytidylyl-transferase
ETP70_RS11585	COG2755	lipolytic protein G-D-S-L family
ETP70_RS11590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ETP70_RS11595	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ETP70_RS11600	COG2089	acid synthase
ETP70_RS11610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ETP70_RS11625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ETP70_RS11630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ETP70_RS11640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ETP70_RS11645	COG0569	domain protein
ETP70_RS11645	COG0475	glutathione-regulated potassium exporter activity
ETP70_RS11650	COG0492	ferredoxin-NADP+ reductase activity
ETP70_RS11655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ETP70_RS11660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ETP70_RS11690	COG0367	asparagine synthase
ETP70_RS11695	COG1301	dicarboxylic acid transport
ETP70_RS11710	COG1253	flavin adenine dinucleotide binding
ETP70_RS11715	COG2239	Acts as a magnesium transporter
ETP70_RS11735	COG0148	phosphopyruvate hydratase activity
ETP70_RS11740	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ETP70_RS11750	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ETP70_RS11755	COG1987	bacterial-type flagellum assembly
ETP70_RS11760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ETP70_RS11770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ETP70_RS11775	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ETP70_RS11780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ETP70_RS11785	COG0575	Belongs to the CDS family
ETP70_RS11825	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ETP70_RS11840	COG0778	Nitroreductase
ETP70_RS11845	COG1797	cobyrinic acid a,c-diamide synthase activity
ETP70_RS11905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ETP70_RS11915	COG1492	cobalamin metabolic process
ETP70_RS11920	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ETP70_RS11930	COG0473	3-isopropylmalate dehydrogenase activity
ETP70_RS11965	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ETP70_RS11970	COG0840	transmembrane signaling receptor activity
ETP70_RS12000	COG0840	transmembrane signaling receptor activity
ETP70_RS12005	COG0840	transmembrane signaling receptor activity
ETP70_RS12005	COG3290	protein histidine kinase activity
ETP70_RS12020	COG1032	radical SAM domain protein
ETP70_RS12030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ETP70_RS12050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ETP70_RS12060	COG3746	phosphate-selective porin O and P
ETP70_RS12080	COG0406	alpha-ribazole phosphatase activity
ETP70_RS12085	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ETP70_RS12100	COG0038	chloride channel
ETP70_RS12105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ETP70_RS12110	COG0569	domain protein
ETP70_RS12120	COG1666	GTP binding
ETP70_RS12130	COG2205	protein histidine kinase activity
ETP70_RS12130	COG5002	protein histidine kinase activity
ETP70_RS12130	COG0784	Response regulator, receiver
ETP70_RS12140	COG0745	RESPONSE REGULATOR receiver
ETP70_RS12150	COG1053	succinate dehydrogenase
ETP70_RS12155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ETP70_RS12160	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ETP70_RS12165	COG1749	Flagellar hook protein flgE
ETP70_RS12175	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ETP70_RS12195	COG0358	DNA primase activity
ETP70_RS12200	COG0642	Histidine kinase
ETP70_RS12245	COG2010	Cytochrome c
ETP70_RS12250	COG0640	Transcriptional regulator
ETP70_RS12255	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ETP70_RS12260	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ETP70_RS12275	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ETP70_RS12290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ETP70_RS12295	COG0429	hydrolase of the alpha beta-hydrolase fold
ETP70_RS12300	COG1217	gtp-binding protein TYPA
ETP70_RS12320	COG0187	DNA topoisomerase II activity
ETP70_RS12325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ETP70_RS12330	COG0233	cytoplasmic translational termination
ETP70_RS12350	COG4943	cyclic-guanylate-specific phosphodiesterase activity
ETP70_RS12460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ETP70_RS12465	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ETP70_RS12555	COG0166	Belongs to the GPI family
ETP70_RS12580	COG4804	nuclease activity
ETP70_RS12585	COG4804	nuclease activity
ETP70_RS12620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ETP70_RS12635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ETP70_RS12640	COG3959	Transketolase, thiamine diphosphate binding domain
ETP70_RS12665	COG5433	transposase activity
ETP70_RS12675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ETP70_RS12680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family