locus-tag	class	description
LOH54_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LOH54_RS00010	COG0592	DNA-directed DNA polymerase activity
LOH54_RS00015	COG0187	DNA topoisomerase II activity
LOH54_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LOH54_RS00040	COG0617	tRNA 3'-terminal CCA addition
LOH54_RS00045	COG0217	transcriptional regulatory protein
LOH54_RS00055	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LOH54_RS00065	COG0129	dihydroxy-acid dehydratase activity
LOH54_RS00070	COG0800	Aldolase
LOH54_RS00115	COG0514	ATP-dependent DNA helicase (RecQ)
LOH54_RS00120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LOH54_RS00135	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LOH54_RS00140	COG0709	Synthesizes selenophosphate from selenide and ATP
LOH54_RS00150	COG1196	nuclear chromosome segregation
LOH54_RS00150	COG3264	Mechanosensitive ion channel
LOH54_RS00170	COG0668	transmembrane transport
LOH54_RS00225	COG1741	Belongs to the pirin family
LOH54_RS00270	COG0500	methyltransferase
LOH54_RS00280	COG4772	TonB-dependent receptor
LOH54_RS00285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LOH54_RS00290	COG2226	methyltransferase
LOH54_RS00300	COG0848	biopolymer transport protein
LOH54_RS00305	COG0811	peptide transport
LOH54_RS00325	COG1120	ATPase activity
LOH54_RS00330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LOH54_RS00340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LOH54_RS00350	COG2346	COG2346, Truncated hemoglobins
LOH54_RS00370	COG0642	Histidine kinase
LOH54_RS00395	COG1368	sulfuric ester hydrolase activity
LOH54_RS00410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LOH54_RS00445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LOH54_RS00480	COG0302	gtp cyclohydrolase
LOH54_RS00485	COG0720	synthase
LOH54_RS00495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOH54_RS00535	COG0137	argininosuccinate synthase activity
LOH54_RS00540	COG0358	DNA primase activity
LOH54_RS00545	COG1592	Rubrerythrin
LOH54_RS00550	COG2897	thiosulfate sulfurtransferase activity
LOH54_RS00555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LOH54_RS00565	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LOH54_RS00570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LOH54_RS00575	COG1238	metal cluster binding
LOH54_RS00605	COG1053	succinate dehydrogenase
LOH54_RS00620	COG1666	GTP binding
LOH54_RS00640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LOH54_RS00660	COG0778	Nitroreductase
LOH54_RS00665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LOH54_RS00665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LOH54_RS00670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LOH54_RS00675	COG2022	thiamine diphosphate biosynthetic process
LOH54_RS00680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LOH54_RS00685	COG0280	phosphate acetyltransferase
LOH54_RS00685	COG0857	belongs to the CobB CobQ family
LOH54_RS00705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOH54_RS00705	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LOH54_RS00760	COG0733	neurotransmitter:sodium symporter activity
LOH54_RS00765	COG0307	riboflavin synthase, alpha
LOH54_RS00830	COG0575	Belongs to the CDS family
LOH54_RS00835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LOH54_RS00845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LOH54_RS00850	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LOH54_RS00865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LOH54_RS00870	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LOH54_RS00875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LOH54_RS00880	COG0148	phosphopyruvate hydratase activity
LOH54_RS00895	COG0646	methionine synthase
LOH54_RS00895	COG1410	methionine synthase
LOH54_RS00910	COG0505	Belongs to the CarA family
LOH54_RS00920	COG3278	Belongs to the heme-copper respiratory oxidase family
LOH54_RS00960	COG1074	ATP-dependent DNA helicase activity
LOH54_RS00965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LOH54_RS00970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LOH54_RS00980	COG3338	carbonate dehydratase activity
LOH54_RS00990	COG0546	phosphoglycolate phosphatase activity
LOH54_RS00995	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LOH54_RS01000	COG1144	Oxidoreductase
LOH54_RS01005	COG0674	pyruvate-flavodoxin oxidoreductase activity
LOH54_RS01010	COG1013	pyruvate-flavodoxin oxidoreductase activity
LOH54_RS01015	COG1854	S-ribosylhomocysteine lyase activity
LOH54_RS01025	COG2855	membrane
LOH54_RS01045	COG3108	Peptidase M15
LOH54_RS01190	COG0242	peptide deformylase activity
LOH54_RS01195	COG0740	serine-type endopeptidase activity
LOH54_RS01200	COG0544	peptidyl-prolyl cis-trans isomerase activity
LOH54_RS01210	COG2906	2 iron, 2 sulfur cluster binding
LOH54_RS01210	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LOH54_RS01210	COG0822	iron-sulfur transferase activity
LOH54_RS01230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LOH54_RS01235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LOH54_RS01240	COG0571	ribonuclease III activity
LOH54_RS01245	COG0328	RNA-DNA hybrid ribonuclease activity
LOH54_RS01265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LOH54_RS01270	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LOH54_RS01275	COG0237	dephospho-CoA kinase activity
LOH54_RS01280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LOH54_RS01285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LOH54_RS01290	COG0268	Binds directly to 16S ribosomal RNA
LOH54_RS01295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LOH54_RS01300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LOH54_RS01315	COG2259	Doxx family
LOH54_RS01325	COG1968	undecaprenyl-diphosphatase activity
LOH54_RS01330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LOH54_RS01335	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LOH54_RS01340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LOH54_RS01355	COG5001	Diguanylate cyclase
LOH54_RS01355	COG3300	MHYT domain
LOH54_RS01385	COG0735	belongs to the Fur family
LOH54_RS01415	COG2304	oxidoreductase activity
LOH54_RS01435	COG0714	Associated with various cellular activities
LOH54_RS01450	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LOH54_RS01455	COG1309	transcriptional regulator
LOH54_RS01470	COG0842	Transport permease protein
LOH54_RS01475	COG1131	(ABC) transporter
LOH54_RS01490	COG1566	PFAM secretion protein HlyD family protein
LOH54_RS01500	COG1090	epimerase
LOH54_RS01520	COG0577	efflux transmembrane transporter activity
LOH54_RS01520	COG1136	(ABC) transporter
LOH54_RS01525	COG0577	efflux transmembrane transporter activity
LOH54_RS01525	COG1136	(ABC) transporter
LOH54_RS01560	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LOH54_RS01580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LOH54_RS01585	COG0840	transmembrane signaling receptor activity
LOH54_RS01605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LOH54_RS01610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LOH54_RS01610	COG0574	Belongs to the PEP-utilizing enzyme family
LOH54_RS01620	COG3174	membrane
LOH54_RS01625	COG1611	Belongs to the LOG family
LOH54_RS01635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LOH54_RS01660	COG1294	oxidase, subunit
LOH54_RS01665	COG1271	oxidase subunit
LOH54_RS01705	COG1234	tRNA 3'-trailer cleavage
LOH54_RS01710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LOH54_RS01725	COG0714	Associated with various cellular activities
LOH54_RS01740	COG0642	Histidine kinase
LOH54_RS01760	COG2217	Heavy metal translocating P-type atpase
LOH54_RS01780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOH54_RS01800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LOH54_RS01805	COG0109	protoheme IX farnesyltransferase activity
LOH54_RS01825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LOH54_RS01845	COG0492	ferredoxin-NADP+ reductase activity
LOH54_RS01855	COG1355	regulation of microtubule-based process
LOH54_RS01860	COG3885	ferrous iron binding
LOH54_RS01860	COG2078	PFAM AMMECR1 domain protein
LOH54_RS01865	COG0475	glutathione-regulated potassium exporter activity
LOH54_RS01865	COG0569	domain protein
LOH54_RS01870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LOH54_RS01880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LOH54_RS01890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LOH54_RS01905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LOH54_RS01910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LOH54_RS01915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LOH54_RS01920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LOH54_RS01925	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LOH54_RS01940	COG2203	Gaf domain
LOH54_RS01940	COG4251	negative regulation of phosphorylation
LOH54_RS01940	COG5001	Diguanylate cyclase
LOH54_RS01940	COG3706	GGDEF domain
LOH54_RS01965	COG0445	tRNA wobble uridine modification
LOH54_RS01975	COG0723	plastoquinol--plastocyanin reductase activity
LOH54_RS01980	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LOH54_RS01980	COG2857	Cytochrome c1
LOH54_RS01990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LOH54_RS01995	COG0602	queuosine metabolic process
LOH54_RS02015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LOH54_RS02030	COG3022	response to hydroperoxide
LOH54_RS02055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LOH54_RS02060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LOH54_RS02075	COG0250	Participates in transcription elongation, termination and antitermination
LOH54_RS02080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LOH54_RS02085	COG0081	regulation of translation
LOH54_RS02090	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LOH54_RS02095	COG0222	ribosome binding
LOH54_RS02100	COG0085	RNA polymerase activity
LOH54_RS02105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LOH54_RS02110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LOH54_RS02115	COG0049	tRNA binding
LOH54_RS02120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LOH54_RS02140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LOH54_RS02145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LOH54_RS02160	COG0772	Belongs to the SEDS family
LOH54_RS02165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LOH54_RS02170	COG0586	Pfam SNARE associated Golgi protein
LOH54_RS02180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LOH54_RS02190	COG0424	maF-like protein
LOH54_RS02200	COG0156	8-amino-7-oxononanoate synthase activity
LOH54_RS02205	COG4172	Belongs to the ABC transporter superfamily
LOH54_RS02220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LOH54_RS02225	COG2205	protein histidine kinase activity
LOH54_RS02225	COG2198	Histidine kinase
LOH54_RS02225	COG0784	Response regulator, receiver
LOH54_RS02230	COG0174	glutamine synthetase
LOH54_RS02235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LOH54_RS02240	COG0826	peptidase U32
LOH54_RS02245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LOH54_RS02260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LOH54_RS02265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LOH54_RS02275	COG1012	belongs to the aldehyde dehydrogenase family
LOH54_RS02285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LOH54_RS02290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LOH54_RS02295	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LOH54_RS02305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LOH54_RS02310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LOH54_RS02315	COG0825	malonyl-CoA metabolic process
LOH54_RS02325	COG0135	phosphoribosylanthranilate isomerase activity
LOH54_RS02330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LOH54_RS02335	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LOH54_RS02340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LOH54_RS02345	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LOH54_RS02355	COG2860	membrane
LOH54_RS02360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LOH54_RS02375	COG0438	transferase activity, transferring glycosyl groups
LOH54_RS02455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LOH54_RS02475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LOH54_RS02495	COG0210	DNA helicase
LOH54_RS02500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LOH54_RS02505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LOH54_RS02515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LOH54_RS02525	COG0335	large ribosomal subunit rRNA binding
LOH54_RS02530	COG0336	Belongs to the RNA methyltransferase TrmD family
LOH54_RS02535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LOH54_RS02545	COG0228	four-way junction DNA binding
LOH54_RS02555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LOH54_RS02570	COG2885	chlorophyll binding
LOH54_RS02570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LOH54_RS02580	COG2885	chlorophyll binding
LOH54_RS02580	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LOH54_RS02585	COG0564	pseudouridine synthase activity
LOH54_RS02590	COG1519	Transferase
LOH54_RS02600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LOH54_RS02615	COG1496	oxidoreductase activity
LOH54_RS02620	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LOH54_RS02625	COG1640	4-alpha-glucanotransferase
LOH54_RS02630	COG1862	Preprotein translocase
LOH54_RS02635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LOH54_RS02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LOH54_RS02650	COG0495	leucyl-tRNA aminoacylation
LOH54_RS02660	COG0285	dihydrofolate synthase activity
LOH54_RS02665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LOH54_RS02710	COG1692	metallophosphoesterase
LOH54_RS02715	COG1979	alcohol dehydrogenase
LOH54_RS02745	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LOH54_RS02750	COG1028	Short-chain dehydrogenase reductase Sdr
LOH54_RS02765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LOH54_RS02780	COG1064	alcohol dehydrogenase
LOH54_RS02785	COG2207	Transcriptional regulator
LOH54_RS02810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LOH54_RS02825	COG1115	amino acid carrier protein
LOH54_RS02830	COG0642	Histidine kinase
LOH54_RS02835	COG0745	RESPONSE REGULATOR receiver
LOH54_RS02855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LOH54_RS02860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LOH54_RS02865	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LOH54_RS02870	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LOH54_RS02875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LOH54_RS02885	COG2217	Heavy metal translocating P-type atpase
LOH54_RS02935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LOH54_RS02940	COG0126	phosphoglycerate kinase activity
LOH54_RS02945	COG0149	triose-phosphate isomerase activity
LOH54_RS02950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LOH54_RS02970	COG0195	Participates in both transcription termination and antitermination
LOH54_RS02980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LOH54_RS02985	COG2121	Domain of unknown function (DUF374)
LOH54_RS03010	COG0037	tRNA processing
LOH54_RS03015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LOH54_RS03020	COG2081	HI0933 family
LOH54_RS03040	COG0752	glycyl-tRNA synthetase alpha subunit
LOH54_RS03045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LOH54_RS03060	COG1757	Na H antiporter
LOH54_RS03080	COG0642	Histidine kinase
LOH54_RS03085	COG2863	cytochrome
LOH54_RS03090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LOH54_RS03095	COG0586	Pfam SNARE associated Golgi protein
LOH54_RS03100	COG0556	nucleotide-excision repair
LOH54_RS03125	COG4969	Belongs to the N-Me-Phe pilin family
LOH54_RS03130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LOH54_RS03135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LOH54_RS03140	COG0305	Participates in initiation and elongation during chromosome replication
LOH54_RS03145	COG0658	competence protein
LOH54_RS03145	COG2333	competence protein COMEC
LOH54_RS03150	COG1295	ribonuclease BN
LOH54_RS03155	COG0277	FAD linked oxidase domain protein
LOH54_RS03165	COG0739	heme binding
LOH54_RS03170	COG2239	Acts as a magnesium transporter
LOH54_RS03185	COG2957	Belongs to the agmatine deiminase family
LOH54_RS03190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LOH54_RS03205	COG0357	Ribosomal RNA small subunit methyltransferase G
LOH54_RS03210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LOH54_RS03215	COG0113	porphobilinogen synthase activity
LOH54_RS03220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LOH54_RS03250	COG3118	belongs to the thioredoxin family
LOH54_RS03260	COG1981	membrane
LOH54_RS03270	COG1160	GTP binding
LOH54_RS03280	COG0438	transferase activity, transferring glycosyl groups
LOH54_RS03285	COG0450	alkyl hydroperoxide reductase
LOH54_RS03290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LOH54_RS03300	COG0105	UTP biosynthetic process
LOH54_RS03310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LOH54_RS03315	COG0416	fatty acid biosynthetic process
LOH54_RS03320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LOH54_RS03340	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LOH54_RS03345	COG0560	Phosphoserine phosphatase
LOH54_RS03365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LOH54_RS03370	COG0629	single-stranded DNA binding
LOH54_RS03375	COG0360	Binds together with S18 to 16S ribosomal RNA
LOH54_RS03385	COG0557	exoribonuclease II activity
LOH54_RS03395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LOH54_RS03400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LOH54_RS03420	COG3437	response regulator, receiver
LOH54_RS03440	COG0659	secondary active sulfate transmembrane transporter activity
LOH54_RS03445	COG0525	valine-tRNA ligase activity
LOH54_RS03450	COG1704	LemA family
LOH54_RS03460	COG0210	DNA helicase
LOH54_RS03465	COG1459	type II secretion system
LOH54_RS03470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LOH54_RS03510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LOH54_RS03515	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LOH54_RS03520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LOH54_RS03525	COG0359	binds to the 23S rRNA
LOH54_RS03535	COG0137	argininosuccinate synthase activity
LOH54_RS03565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LOH54_RS03575	COG0564	pseudouridine synthase activity
LOH54_RS03580	COG0772	Belongs to the SEDS family
LOH54_RS03590	COG0386	Belongs to the glutathione peroxidase family
LOH54_RS03600	COG2308	Evidence 4 Homologs of previously reported genes of
LOH54_RS03625	COG2308	Evidence 4 Homologs of previously reported genes of
LOH54_RS03670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LOH54_RS03675	COG0824	Thioesterase
LOH54_RS03685	COG0243	molybdopterin cofactor binding
LOH54_RS03690	COG1116	anion transmembrane transporter activity
LOH54_RS03690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LOH54_RS03700	COG1116	anion transmembrane transporter activity
LOH54_RS03710	COG1648	precorrin-2 dehydrogenase activity
LOH54_RS03710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LOH54_RS03715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LOH54_RS03725	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LOH54_RS03730	COG2815	serine threonine protein kinase
LOH54_RS03730	COG0515	serine threonine protein kinase
LOH54_RS03740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LOH54_RS03740	COG1017	nitric oxide dioxygenase activity
LOH54_RS03755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LOH54_RS03810	COG0837	glucose binding
LOH54_RS03820	COG0243	molybdopterin cofactor binding
LOH54_RS03825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LOH54_RS03860	COG0736	holo-[acyl-carrier-protein] synthase activity
LOH54_RS03935	COG0642	Histidine kinase
LOH54_RS03940	COG0745	RESPONSE REGULATOR receiver
LOH54_RS03960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LOH54_RS03965	COG0552	protein localization to endoplasmic reticulum
LOH54_RS03975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LOH54_RS03980	COG1418	mRNA catabolic process
LOH54_RS04005	COG0500	methyltransferase
LOH54_RS04010	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LOH54_RS04010	COG2050	protein possibly involved in aromatic compounds catabolism
LOH54_RS04020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LOH54_RS04040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LOH54_RS04050	COG1473	amidohydrolase
LOH54_RS04060	COG0251	oxidation-reduction process
LOH54_RS04065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LOH54_RS04070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LOH54_RS04075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LOH54_RS04080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LOH54_RS04085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LOH54_RS04095	COG1192	Involved in chromosome partitioning
LOH54_RS04100	COG1475	DNA binding
LOH54_RS04105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LOH54_RS04115	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LOH54_RS04120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LOH54_RS04125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LOH54_RS04130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LOH54_RS04135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LOH54_RS04140	COG0811	peptide transport
LOH54_RS04145	COG0848	biopolymer transport protein
LOH54_RS04155	COG0823	Involved in the tonB-independent uptake of proteins
LOH54_RS04160	COG2885	chlorophyll binding
LOH54_RS04170	COG1047	Peptidyl-prolyl cis-trans
LOH54_RS04180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LOH54_RS04185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LOH54_RS04185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LOH54_RS04190	COG1671	Belongs to the UPF0178 family
LOH54_RS04195	COG0513	Belongs to the DEAD box helicase family
LOH54_RS04200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LOH54_RS04205	COG0037	tRNA processing
LOH54_RS04230	COG2270	Major facilitator Superfamily
LOH54_RS04250	COG1739	Uncharacterized protein family UPF0029
LOH54_RS04285	COG1794	racemase activity, acting on amino acids and derivatives
LOH54_RS04295	COG2350	Protein conserved in bacteria
LOH54_RS04335	COG1704	LemA family
LOH54_RS04340	COG1254	Belongs to the acylphosphatase family
LOH54_RS04345	COG2081	HI0933 family
LOH54_RS04355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LOH54_RS04360	COG0750	zinc metalloprotease
LOH54_RS04365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LOH54_RS04370	COG1028	Short-chain dehydrogenase reductase Sdr
LOH54_RS04375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LOH54_RS04380	COG0612	Peptidase, M16
LOH54_RS04385	COG0167	dihydroorotate dehydrogenase activity
LOH54_RS04390	COG2239	Acts as a magnesium transporter
LOH54_RS04395	COG0840	transmembrane signaling receptor activity
LOH54_RS04405	COG0215	cysteine-tRNA ligase activity
LOH54_RS04410	COG0728	peptidoglycan biosynthetic process
LOH54_RS04420	COG0632	four-way junction helicase activity
LOH54_RS04425	COG1181	Belongs to the D-alanine--D-alanine ligase family
LOH54_RS04435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LOH54_RS04500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LOH54_RS04505	COG0436	Aminotransferase
LOH54_RS04525	COG1193	negative regulation of DNA recombination
LOH54_RS04555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LOH54_RS04575	COG0196	riboflavin kinase activity
LOH54_RS04580	COG0356	it plays a direct role in the translocation of protons across the membrane
LOH54_RS04590	COG0352	thiamine-phosphate diphosphorylase activity
LOH54_RS04595	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LOH54_RS04600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LOH54_RS04610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LOH54_RS04615	COG0471	metal ion transport
LOH54_RS04620	COG3021	interspecies interaction between organisms
LOH54_RS04640	COG0488	(ABC) transporter
LOH54_RS04655	COG2885	chlorophyll binding
LOH54_RS04665	COG3023	N-Acetylmuramoyl-L-alanine amidase
LOH54_RS04680	COG0501	Belongs to the peptidase M48B family
LOH54_RS04685	COG2890	protein-(glutamine-N5) methyltransferase activity
LOH54_RS04705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LOH54_RS04710	COG0849	cell division
LOH54_RS04740	COG0583	DNA-binding transcription factor activity
LOH54_RS04745	COG0275	rRNA processing
LOH54_RS04765	COG0142	geranyltranstransferase activity
LOH54_RS04770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LOH54_RS04775	COG0442	prolyl-tRNA aminoacylation
LOH54_RS04790	COG0181	hydroxymethylbilane synthase activity
LOH54_RS04800	COG0165	Argininosuccinate lyase
LOH54_RS04810	COG0537	adenosine 5'-monophosphoramidase activity
LOH54_RS04815	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LOH54_RS04820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOH54_RS04820	COG0072	phenylalanine-tRNA ligase activity
LOH54_RS04825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LOH54_RS04830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LOH54_RS04835	COG1185	polyribonucleotide nucleotidyltransferase activity
LOH54_RS04835	COG0539	negative regulation of cytoplasmic translation
LOH54_RS04840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LOH54_RS04870	COG0739	heme binding
LOH54_RS04880	COG1280	lysine exporter protein (LysE YggA)
LOH54_RS04905	COG1331	Highly conserved protein containing a thioredoxin domain
LOH54_RS04920	COG2337	Toxic component of a toxin-antitoxin (TA) module
LOH54_RS05010	COG4974	Belongs to the 'phage' integrase family
LOH54_RS05015	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
LOH54_RS05035	COG1881	PFAM PEBP family protein
LOH54_RS05040	COG3647	Membrane
LOH54_RS05045	COG3706	GGDEF domain
LOH54_RS05055	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LOH54_RS05060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LOH54_RS05085	COG1032	radical SAM domain protein
LOH54_RS05090	COG2205	protein histidine kinase activity
LOH54_RS05090	COG3437	response regulator, receiver
LOH54_RS05090	COG3850	Histidine kinase
LOH54_RS05090	COG4999	Histidine kinase
LOH54_RS05095	COG0784	Response regulator, receiver
LOH54_RS05095	COG2205	protein histidine kinase activity
LOH54_RS05095	COG5002	protein histidine kinase activity
LOH54_RS05105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LOH54_RS05110	COG0802	atpase or kinase
LOH54_RS05115	COG1137	ATPase activity
LOH54_RS05145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LOH54_RS05155	COG0028	Belongs to the TPP enzyme family
LOH54_RS05160	COG0440	acetolactate synthase activity
LOH54_RS05165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOH54_RS05170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOH54_RS05175	COG0436	Aminotransferase
LOH54_RS05185	COG1045	serine acetyltransferase
LOH54_RS05190	COG1166	arginine decarboxylase activity
LOH54_RS05195	COG0124	histidyl-tRNA synthetase
LOH54_RS05200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LOH54_RS05210	COG0163	prenyltransferase activity
LOH54_RS05215	COG0840	transmembrane signaling receptor activity
LOH54_RS05220	COG0616	signal peptide processing
LOH54_RS05225	COG0402	S-adenosylhomocysteine deaminase activity
LOH54_RS05230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LOH54_RS05235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LOH54_RS05240	COG0455	bacterial-type flagellum organization
LOH54_RS05265	COG1252	NADH dehydrogenase
LOH54_RS05270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LOH54_RS05350	COG0339	signal peptide processing
LOH54_RS05390	COG2200	EAL domain
LOH54_RS05390	COG3287	FIST C domain
LOH54_RS05390	COG2199	diguanylate cyclase activity
LOH54_RS05405	COG1196	nuclear chromosome segregation
LOH54_RS05405	COG1674	ftsk spoiiie
LOH54_RS05410	COG1049	propionate catabolic process, 2-methylcitrate cycle
LOH54_RS05425	COG2824	Alkylphosphonate utilization operon protein PhnA
LOH54_RS05455	COG1902	pentaerythritol trinitrate reductase activity
LOH54_RS05475	COG0402	S-adenosylhomocysteine deaminase activity
LOH54_RS05505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LOH54_RS05520	COG0778	Nitroreductase
LOH54_RS05560	COG0326	Molecular chaperone. Has ATPase activity
LOH54_RS05565	COG0101	tRNA pseudouridine synthase activity
LOH54_RS05580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LOH54_RS05585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LOH54_RS05590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LOH54_RS05595	COG0671	phosphoesterase, PA-phosphatase related
LOH54_RS05635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LOH54_RS05645	COG1959	2 iron, 2 sulfur cluster binding
LOH54_RS05660	COG0069	glutamate synthase activity
LOH54_RS05660	COG0070	glutamate synthase
LOH54_RS05660	COG0067	glutamate synthase
LOH54_RS05665	COG0493	'glutamate synthase
LOH54_RS05670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LOH54_RS05675	COG0352	thiamine-phosphate diphosphorylase activity
LOH54_RS05680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LOH54_RS05695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LOH54_RS05700	COG0745	RESPONSE REGULATOR receiver
LOH54_RS05710	COG0730	response to heat
LOH54_RS05715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LOH54_RS05725	COG0300	oxidoreductase activity
LOH54_RS05755	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
LOH54_RS05765	COG4895	conserved protein (DUF2196)
LOH54_RS05770	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LOH54_RS05810	COG1017	nitric oxide dioxygenase activity
LOH54_RS05810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LOH54_RS05825	COG2045	Belongs to the ComB family
LOH54_RS05840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LOH54_RS05860	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LOH54_RS05885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LOH54_RS05910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LOH54_RS05910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LOH54_RS05915	COG1333	cytochrome c biogenesis protein
LOH54_RS05915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LOH54_RS05935	COG2703	oxygen carrier activity
LOH54_RS05940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LOH54_RS05945	COG1643	Atp-dependent helicase
LOH54_RS05950	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LOH54_RS05955	COG0653	protein targeting
LOH54_RS05965	COG1858	cytochrome C peroxidase
LOH54_RS06025	COG2326	polyphosphate kinase activity
LOH54_RS06045	COG0189	ligase activity
LOH54_RS06045	COG4067	protein conserved in archaea
LOH54_RS06085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LOH54_RS06090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LOH54_RS06115	COG3665	Urea carboxylase-associated protein
LOH54_RS06130	COG0439	Biotin carboxylase
LOH54_RS06160	COG3384	dioxygenase
LOH54_RS06170	COG0343	queuine tRNA-ribosyltransferase activity
LOH54_RS06180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LOH54_RS06190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LOH54_RS06195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LOH54_RS06205	COG0521	Mo-molybdopterin cofactor biosynthetic process
LOH54_RS06245	COG0708	Exodeoxyribonuclease III
LOH54_RS06250	COG2048	Heterodisulfide reductase, subunit B
LOH54_RS06270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LOH54_RS06275	COG0585	pseudouridine synthase activity
LOH54_RS06290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOH54_RS06300	COG0012	GTP binding
LOH54_RS06315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LOH54_RS06320	COG0586	Pfam SNARE associated Golgi protein
LOH54_RS06325	COG0133	tryptophan synthase activity
LOH54_RS06330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LOH54_RS06335	COG0698	ribose 5-phosphate isomerase
LOH54_RS06340	COG1994	Peptidase M50
LOH54_RS06345	COG0681	Belongs to the peptidase S26 family
LOH54_RS06350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LOH54_RS06360	COG2301	Belongs to the HpcH HpaI aldolase family
LOH54_RS06365	COG1301	dicarboxylic acid transport
LOH54_RS06375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LOH54_RS06395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LOH54_RS06400	COG0066	3-isopropylmalate dehydratase activity
LOH54_RS06405	COG0473	3-isopropylmalate dehydrogenase activity
LOH54_RS06410	COG0788	formyltetrahydrofolate deformylase activity
LOH54_RS06435	COG2171	N-acyltransferase activity
LOH54_RS06445	COG0501	Belongs to the peptidase M48B family
LOH54_RS06465	COG1408	metallophosphoesterase
LOH54_RS06475	COG0563	adenylate kinase activity
LOH54_RS06480	COG0563	adenylate kinase activity
LOH54_RS06485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LOH54_RS06495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LOH54_RS06500	COG0497	DNA recombination
LOH54_RS06505	COG0084	hydrolase, TatD family'
LOH54_RS06510	COG1388	LysM domain
LOH54_RS06510	COG0791	NLP P60 protein
LOH54_RS06515	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LOH54_RS06520	COG0131	Imidazoleglycerol-phosphate dehydratase
LOH54_RS06525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LOH54_RS06540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LOH54_RS06555	COG0768	penicillin binding
LOH54_RS06565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LOH54_RS06580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LOH54_RS06600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LOH54_RS06605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LOH54_RS06610	COG0387	Pfam Sodium calcium exchanger
LOH54_RS06620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOH54_RS06620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOH54_RS06630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LOH54_RS06655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LOH54_RS06670	COG2201	protein-glutamate methylesterase activity
LOH54_RS06680	COG0372	Belongs to the citrate synthase family
LOH54_RS06710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LOH54_RS06710	COG0674	pyruvate-flavodoxin oxidoreductase activity
LOH54_RS06725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LOH54_RS06730	COG0045	succinate-CoA ligase (ADP-forming) activity
LOH54_RS06735	COG0114	fumarate hydratase activity
LOH54_RS06740	COG0039	L-malate dehydrogenase activity
LOH54_RS06760	COG1730	sister chromatid segregation
LOH54_RS06790	COG0546	phosphoglycolate phosphatase activity
LOH54_RS06815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LOH54_RS06840	COG2814	Major facilitator Superfamily
LOH54_RS06855	COG0484	heat shock protein binding
LOH54_RS06880	COG0748	coenzyme F420 binding
LOH54_RS06895	COG1573	uracil-dna glycosylase
LOH54_RS06905	COG0824	Thioesterase
LOH54_RS06910	COG0058	SHG alpha-glucan phosphorylase activity
LOH54_RS06915	COG0166	Belongs to the GPI family
LOH54_RS06920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LOH54_RS06925	COG0297	glycogen (starch) synthase activity
LOH54_RS06930	COG0297	glycogen (starch) synthase activity
LOH54_RS06945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LOH54_RS06955	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LOH54_RS06960	COG1393	Belongs to the ArsC family
LOH54_RS06970	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LOH54_RS06985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LOH54_RS06990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LOH54_RS07005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LOH54_RS07010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LOH54_RS07020	COG1122	ATPase activity
LOH54_RS07030	COG0310	cobalt ion transport
LOH54_RS07060	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LOH54_RS07095	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LOH54_RS07100	COG0484	heat shock protein binding
LOH54_RS07105	COG0077	Prephenate dehydratase
LOH54_RS07105	COG1605	Chorismate mutase
LOH54_RS07110	COG4106	trans-aconitate 2-methyltransferase activity
LOH54_RS07130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LOH54_RS07140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOH54_RS07150	COG0673	inositol 2-dehydrogenase activity
LOH54_RS07155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOH54_RS07180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LOH54_RS07190	COG0500	methyltransferase
LOH54_RS07200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LOH54_RS07205	COG0564	pseudouridine synthase activity
LOH54_RS07215	COG4232	protein-disulfide reductase activity
LOH54_RS07235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LOH54_RS07260	COG1331	Highly conserved protein containing a thioredoxin domain
LOH54_RS07275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LOH54_RS07280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LOH54_RS07285	COG1324	tolerance protein
LOH54_RS07290	COG2020	methyltransferase activity
LOH54_RS07295	COG1346	cytolysis
LOH54_RS07300	COG1380	Effector of murein hydrolase LrgA
LOH54_RS07305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LOH54_RS07310	COG1663	tetraacyldisaccharide 4'-kinase activity
LOH54_RS07315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LOH54_RS07320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LOH54_RS07330	COG2833	Protein of unknown function (DUF455)
LOH54_RS07340	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LOH54_RS07355	COG2755	lipolytic protein G-D-S-L family
LOH54_RS07360	COG0482	sulfurtransferase activity
LOH54_RS07365	COG0642	Histidine kinase
LOH54_RS07370	COG0745	RESPONSE REGULATOR receiver
LOH54_RS07395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LOH54_RS07405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LOH54_RS07410	COG2195	Cleaves the N-terminal amino acid of tripeptides
LOH54_RS07415	COG2226	methyltransferase
LOH54_RS07535	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LOH54_RS07555	COG0439	Biotin carboxylase
LOH54_RS07570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LOH54_RS07575	COG0667	Aldo Keto reductase
LOH54_RS07590	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LOH54_RS07595	COG0633	Ferredoxin
LOH54_RS07615	COG0716	FMN binding
LOH54_RS07625	COG1433	Dinitrogenase iron-molybdenum cofactor
LOH54_RS07630	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOH54_RS07650	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOH54_RS07665	COG3706	GGDEF domain
LOH54_RS07695	COG0135	phosphoribosylanthranilate isomerase activity
LOH54_RS07715	COG1278	Cold shock
LOH54_RS07720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LOH54_RS07735	COG0488	(ABC) transporter
LOH54_RS07740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LOH54_RS07750	COG1054	Belongs to the UPF0176 family
LOH54_RS07755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LOH54_RS07770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LOH54_RS07805	COG3527	Alpha-acetolactate decarboxylase
LOH54_RS07820	COG0110	maltose O-acetyltransferase activity
LOH54_RS07840	COG0534	Mate efflux family protein
LOH54_RS07860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LOH54_RS07865	COG1451	nucleotide metabolic process
LOH54_RS07910	COG2226	methyltransferase
LOH54_RS07920	COG1490	D-aminoacyl-tRNA deacylase activity
LOH54_RS07960	COG0656	L-ascorbic acid biosynthetic process
LOH54_RS07975	COG1215	transferase activity, transferring glycosyl groups
LOH54_RS07985	COG3769	mannosylglycerate metabolic process
LOH54_RS07990	COG0647	UMP catabolic process
LOH54_RS08010	COG0686	Belongs to the AlaDH PNT family
LOH54_RS08020	COG2066	Belongs to the glutaminase family
LOH54_RS08060	COG0659	secondary active sulfate transmembrane transporter activity
LOH54_RS08070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LOH54_RS08080	COG1538	Outer membrane efflux protein
LOH54_RS08120	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOH54_RS08125	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOH54_RS08135	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
LOH54_RS08165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LOH54_RS08190	COG0740	serine-type endopeptidase activity
LOH54_RS08195	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LOH54_RS08230	COG4221	oxidoreductase activity
LOH54_RS08255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LOH54_RS08265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LOH54_RS08300	COG1362	aminopeptidase activity
LOH54_RS08325	COG3118	belongs to the thioredoxin family
LOH54_RS08335	COG2084	Dehydrogenase
LOH54_RS08355	COG0587	DNA-directed DNA polymerase activity
LOH54_RS08370	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
LOH54_RS08375	COG0348	domain, Protein
LOH54_RS08395	COG0564	pseudouridine synthase activity
LOH54_RS08410	COG3123	guanosine phosphorylase activity
LOH54_RS08420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LOH54_RS08445	COG0776	regulation of translation
LOH54_RS08450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LOH54_RS08460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LOH54_RS08465	COG0306	phosphate transporter
LOH54_RS08485	COG0527	aspartate kinase activity
LOH54_RS08490	COG0494	nUDIX hydrolase
LOH54_RS08495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LOH54_RS08500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LOH54_RS08505	COG0805	protein transport
LOH54_RS08510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LOH54_RS08535	COG2861	carbohydrate metabolic process
LOH54_RS08545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LOH54_RS08545	COG0475	glutathione-regulated potassium exporter activity
LOH54_RS08560	COG2010	Cytochrome c
LOH54_RS08575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LOH54_RS08590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LOH54_RS08595	COG0617	tRNA 3'-terminal CCA addition
LOH54_RS08600	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LOH54_RS08610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LOH54_RS08615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LOH54_RS08625	COG0706	membrane insertase activity
LOH54_RS08630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LOH54_RS08635	COG0594	ribonuclease P activity
LOH54_RS08640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LOH54_RS08650	COG0542	response to heat
LOH54_RS08655	COG0793	Belongs to the peptidase S41A family
LOH54_RS08660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LOH54_RS08665	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LOH54_RS08670	COG0047	phosphoribosylformylglycinamidine synthase activity
LOH54_RS08680	COG0204	Acyl-transferase
LOH54_RS08685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LOH54_RS08690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LOH54_RS08695	COG3150	esterase
LOH54_RS08705	COG2197	response regulator
LOH54_RS08725	COG5002	protein histidine kinase activity
LOH54_RS08725	COG2205	protein histidine kinase activity
LOH54_RS08725	COG0784	Response regulator, receiver
LOH54_RS08730	COG2205	protein histidine kinase activity
LOH54_RS08730	COG0784	Response regulator, receiver
LOH54_RS08730	COG2198	Histidine kinase
LOH54_RS08745	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LOH54_RS08755	COG0443	Heat shock 70 kDa protein
LOH54_RS08760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LOH54_RS08790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LOH54_RS08795	COG0481	GTPase activity
LOH54_RS08800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LOH54_RS08805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LOH54_RS08835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LOH54_RS08845	COG0517	IMP dehydrogenase activity
LOH54_RS08845	COG0516	GMP reductase activity
LOH54_RS08850	COG0154	amidase activity
LOH54_RS08855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LOH54_RS08860	COG1058	Belongs to the CinA family
LOH54_RS08860	COG1546	Belongs to the CinA family
LOH54_RS08880	COG2706	6-phosphogluconolactonase activity
LOH54_RS08895	COG0719	Fe-S assembly protein
LOH54_RS08900	COG0396	ATPase activity
LOH54_RS08905	COG0719	Fe-S assembly protein
LOH54_RS08915	COG2151	metal-sulfur cluster biosynthetic enzyme
LOH54_RS08930	COG0676	glucose-6-phosphate 1-epimerase activity
LOH54_RS08935	COG0179	Fumarylacetoacetate (FAA) hydrolase
LOH54_RS08945	COG0471	metal ion transport
LOH54_RS08950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LOH54_RS08960	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LOH54_RS08965	COG2354	Protein conserved in bacteria
LOH54_RS08990	COG1472	Belongs to the glycosyl hydrolase 3 family
LOH54_RS09030	COG3246	L-lysine catabolic process to acetate
LOH54_RS09035	COG4681	YaeQ
LOH54_RS09040	COG3001	Fructosamine kinase
LOH54_RS09045	COG0469	pyruvate kinase activity
LOH54_RS09050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LOH54_RS09070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LOH54_RS09070	COG2111	Na H antiporter
LOH54_RS09075	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LOH54_RS09080	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LOH54_RS09090	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LOH54_RS09090	COG3261	NADH dehydrogenase
LOH54_RS09100	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LOH54_RS09105	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LOH54_RS09110	COG0284	orotidine-5'-phosphate decarboxylase activity
LOH54_RS09125	COG0582	viral genome integration into host DNA
LOH54_RS09150	COG0513	Belongs to the DEAD box helicase family
LOH54_RS09165	COG1278	Cold shock
LOH54_RS09185	COG0513	Belongs to the DEAD box helicase family
LOH54_RS09190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LOH54_RS09230	COG0842	Transport permease protein
LOH54_RS09235	COG0842	Transport permease protein
LOH54_RS09235	COG1129	ABC transporter
LOH54_RS09240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LOH54_RS09265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LOH54_RS09270	COG0531	amino acid
LOH54_RS09280	COG3842	ATPase activity
LOH54_RS09320	COG0534	Mate efflux family protein
LOH54_RS09330	COG1013	pyruvate-flavodoxin oxidoreductase activity
LOH54_RS09360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LOH54_RS09395	COG0745	RESPONSE REGULATOR receiver
LOH54_RS09400	COG0642	Histidine kinase
LOH54_RS09410	COG1090	epimerase
LOH54_RS09445	COG1278	Cold shock
LOH54_RS09455	COG0513	Belongs to the DEAD box helicase family
LOH54_RS09475	COG0697	spore germination
LOH54_RS09495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LOH54_RS09500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LOH54_RS09505	COG2176	DNA-directed DNA polymerase activity
LOH54_RS09520	COG3162	membrane
LOH54_RS09530	COG0745	RESPONSE REGULATOR receiver
LOH54_RS09545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LOH54_RS09550	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LOH54_RS09570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LOH54_RS09575	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOH54_RS09580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LOH54_RS09585	COG1077	Cell shape determining protein MreB Mrl
LOH54_RS09600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LOH54_RS09615	COG0754	glutathionylspermidine amidase activity
LOH54_RS09640	COG0628	permease
LOH54_RS09645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOH54_RS09650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LOH54_RS09685	COG1570	exodeoxyribonuclease VII activity
LOH54_RS09700	COG0779	Required for maturation of 30S ribosomal subunits
LOH54_RS09710	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LOH54_RS09720	COG0083	homoserine kinase activity
LOH54_RS09730	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LOH54_RS09740	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LOH54_RS09745	COG0157	Belongs to the NadC ModD family
LOH54_RS09755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LOH54_RS09765	COG0745	RESPONSE REGULATOR receiver
LOH54_RS09770	COG0642	Histidine kinase
LOH54_RS09775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LOH54_RS09785	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LOH54_RS09800	COG2081	HI0933 family
LOH54_RS09805	COG1272	protein, Hemolysin III
LOH54_RS09860	COG0714	Associated with various cellular activities
LOH54_RS09905	COG0488	(ABC) transporter
LOH54_RS09910	COG3012	SEC-C Motif Domain Protein
LOH54_RS09940	COG0459	protein refolding
LOH54_RS09945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LOH54_RS09955	COG0745	RESPONSE REGULATOR receiver
LOH54_RS09985	COG0848	biopolymer transport protein
LOH54_RS09990	COG0811	peptide transport
LOH54_RS09995	COG0642	Histidine kinase
LOH54_RS10005	COG0418	dihydroorotase activity
LOH54_RS10030	COG0489	protein tyrosine kinase activity
LOH54_RS10035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LOH54_RS10040	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LOH54_RS10040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LOH54_RS10050	COG2046	Belongs to the sulfate adenylyltransferase family
LOH54_RS10055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LOH54_RS10065	COG0247	lactate metabolic process
LOH54_RS10070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LOH54_RS10090	COG0848	biopolymer transport protein
LOH54_RS10095	COG0811	peptide transport
LOH54_RS10100	COG0811	peptide transport
LOH54_RS10120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LOH54_RS10125	COG0581	inorganic phosphate transmembrane transporter activity
LOH54_RS10130	COG0573	inorganic phosphate transmembrane transporter activity
LOH54_RS10140	COG0745	RESPONSE REGULATOR receiver
LOH54_RS10145	COG0704	Plays a role in the regulation of phosphate uptake
LOH54_RS10150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LOH54_RS10170	COG2205	protein histidine kinase activity
LOH54_RS10170	COG5002	protein histidine kinase activity
LOH54_RS10170	COG0784	Response regulator, receiver
LOH54_RS10175	COG0242	peptide deformylase activity
LOH54_RS10210	COG0308	aminopeptidase N
LOH54_RS10225	COG0006	proline dipeptidase activity
LOH54_RS10230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LOH54_RS10235	COG0534	Mate efflux family protein
LOH54_RS10240	COG1183	phosphatidylcholine synthase activity
LOH54_RS10250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LOH54_RS10255	COG2264	protein methyltransferase activity
LOH54_RS10260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LOH54_RS10265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LOH54_RS10275	COG0859	PFAM glycosyl transferase family 9
LOH54_RS10290	COG0742	ribosomal rna small subunit methyltransferase
LOH54_RS10295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LOH54_RS10305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LOH54_RS10315	COG0484	heat shock protein binding
LOH54_RS10325	COG0138	bifunctional purine biosynthesis protein purh
LOH54_RS10330	COG3437	response regulator, receiver
LOH54_RS10330	COG0784	Response regulator, receiver
LOH54_RS10340	COG3746	phosphate-selective porin O and P
LOH54_RS10365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LOH54_RS10370	COG0134	indole-3-glycerol-phosphate synthase activity
LOH54_RS10380	COG0727	PFAM Uncharacterised protein family (UPF0153)
LOH54_RS10385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LOH54_RS10390	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LOH54_RS10395	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LOH54_RS10405	COG2404	hydrolase activity, acting on ester bonds
LOH54_RS10410	COG0860	N-Acetylmuramoyl-L-alanine amidase
LOH54_RS10420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LOH54_RS10425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LOH54_RS10430	COG1758	RNA polymerase activity
LOH54_RS10435	COG0528	UMP kinase activity
LOH54_RS10445	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LOH54_RS10445	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LOH54_RS10445	COG1013	pyruvate-flavodoxin oxidoreductase activity
LOH54_RS10445	COG0674	pyruvate-flavodoxin oxidoreductase activity
LOH54_RS10450	COG0205	6-phosphofructokinase activity
LOH54_RS10465	COG3540	Alkaline phosphatase
LOH54_RS10485	COG0519	Catalyzes the synthesis of GMP from XMP
LOH54_RS10485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LOH54_RS10490	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LOH54_RS10495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LOH54_RS10505	COG0322	excinuclease ABC activity
LOH54_RS10510	COG0840	transmembrane signaling receptor activity
LOH54_RS10545	COG4948	Mandelate Racemase Muconate Lactonizing
LOH54_RS10555	COG2827	Endonuclease containing a URI domain
LOH54_RS10565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LOH54_RS10590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LOH54_RS10595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LOH54_RS10600	COG0612	Peptidase, M16
LOH54_RS10605	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LOH54_RS10610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LOH54_RS10615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LOH54_RS10620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LOH54_RS10630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LOH54_RS10640	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LOH54_RS10660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LOH54_RS10665	COG1185	polyribonucleotide nucleotidyltransferase activity
LOH54_RS10675	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LOH54_RS10690	COG0159	tryptophan synthase activity
LOH54_RS10695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LOH54_RS10705	COG2255	four-way junction helicase activity
LOH54_RS10710	COG0628	permease
LOH54_RS10730	COG3787	Belongs to the UPF0306 family
LOH54_RS10750	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LOH54_RS10765	COG1127	ABC transporter
LOH54_RS10770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LOH54_RS10780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LOH54_RS10785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LOH54_RS10805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LOH54_RS10810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LOH54_RS10820	COG0642	Histidine kinase
LOH54_RS10825	COG0745	RESPONSE REGULATOR receiver
LOH54_RS10830	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LOH54_RS10840	COG1183	phosphatidylcholine synthase activity
LOH54_RS10855	COG1322	Protein conserved in bacteria
LOH54_RS10860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LOH54_RS10865	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LOH54_RS10870	COG0513	Belongs to the DEAD box helicase family
LOH54_RS10875	COG1459	type II secretion system
LOH54_RS10885	COG2165	general secretion pathway protein
LOH54_RS10910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LOH54_RS10915	COG4796	Type ii and iii secretion system protein
LOH54_RS10935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LOH54_RS10945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LOH54_RS10960	COG0019	diaminopimelate decarboxylase activity
LOH54_RS10970	COG0193	aminoacyl-tRNA hydrolase activity
LOH54_RS10975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LOH54_RS10985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LOH54_RS11005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LOH54_RS11010	COG0542	response to heat
LOH54_RS11015	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LOH54_RS11025	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOH54_RS11030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LOH54_RS11035	COG2873	o-acetylhomoserine
LOH54_RS11040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LOH54_RS11045	COG0540	Belongs to the ATCase OTCase family
LOH54_RS11050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LOH54_RS11090	COG0045	succinate-CoA ligase (ADP-forming) activity
LOH54_RS11105	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LOH54_RS11110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LOH54_RS11115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LOH54_RS11120	COG0004	ammonium transporteR
LOH54_RS11125	COG0347	Belongs to the P(II) protein family
LOH54_RS11135	COG0004	ammonium transporteR
LOH54_RS11145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LOH54_RS11155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LOH54_RS11160	COG0731	radical SAM domain protein
LOH54_RS11170	COG1132	(ABC) transporter
LOH54_RS11185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LOH54_RS11190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LOH54_RS11200	COG0463	Glycosyl transferase, family 2
LOH54_RS11220	COG0438	transferase activity, transferring glycosyl groups
LOH54_RS11235	COG1088	dTDP-glucose 4,6-dehydratase activity
LOH54_RS11240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LOH54_RS11270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LOH54_RS11270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LOH54_RS11280	COG2863	cytochrome
LOH54_RS11290	COG1073	alpha beta
LOH54_RS11295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LOH54_RS11300	COG2203	Gaf domain
LOH54_RS11300	COG3706	GGDEF domain
LOH54_RS11300	COG5001	Diguanylate cyclase
LOH54_RS11300	COG4251	negative regulation of phosphorylation
LOH54_RS11305	COG0586	Pfam SNARE associated Golgi protein
LOH54_RS11320	COG1007	ATP synthesis coupled electron transport
LOH54_RS11330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LOH54_RS11335	COG0713	ATP synthesis coupled electron transport
LOH54_RS11340	COG0839	Belongs to the complex I subunit 6 family
LOH54_RS11345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LOH54_RS11350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LOH54_RS11355	COG1034	ATP synthesis coupled electron transport
LOH54_RS11375	COG0649	NAD binding
LOH54_RS11380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LOH54_RS11385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LOH54_RS11390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LOH54_RS11395	COG1222	aaa ATPase
LOH54_RS11405	COG2067	long-chain fatty acid transport protein
LOH54_RS11420	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LOH54_RS11435	COG0791	NLP P60 protein
LOH54_RS11440	COG0667	Aldo Keto reductase
LOH54_RS11460	COG1596	polysaccharide export
LOH54_RS11460	COG1555	photosystem II stabilization
LOH54_RS11485	COG0662	Cupin 2, conserved barrel domain protein
LOH54_RS11485	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LOH54_RS11495	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LOH54_RS11505	COG1216	Glycosyl transferase, family 2
LOH54_RS11520	COG3551	Protein conserved in bacteria
LOH54_RS11530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LOH54_RS11535	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LOH54_RS11545	COG0529	Catalyzes the synthesis of activated sulfate
LOH54_RS11555	COG3273	potassium ion transport
LOH54_RS11555	COG0471	metal ion transport
LOH54_RS11560	COG2895	sulfate adenylyltransferase (ATP) activity
LOH54_RS11565	COG0175	sulfate reduction
LOH54_RS11585	COG1872	DUF167
LOH54_RS11590	COG0018	arginyl-trna synthetase
LOH54_RS11595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LOH54_RS11600	COG0194	GDP metabolic process
LOH54_RS11615	COG1136	(ABC) transporter
LOH54_RS11620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LOH54_RS11625	COG0052	Belongs to the universal ribosomal protein uS2 family
LOH54_RS11635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LOH54_RS11640	COG1683	Conserved Protein
LOH54_RS11645	COG1012	belongs to the aldehyde dehydrogenase family
LOH54_RS11660	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LOH54_RS11665	COG2252	PERMEase
LOH54_RS11685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LOH54_RS11700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LOH54_RS11700	COG0140	phosphoribosyl-ATP diphosphatase activity
LOH54_RS11705	COG1242	4 iron, 4 sulfur cluster binding
LOH54_RS11710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LOH54_RS11715	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LOH54_RS11720	COG0492	ferredoxin-NADP+ reductase activity
LOH54_RS11725	COG3118	belongs to the thioredoxin family
LOH54_RS11730	COG0792	nuclease activity
LOH54_RS11735	COG3383	formate dehydrogenase (NAD+) activity
LOH54_RS11745	COG0460	homoserine dehydrogenase
LOH54_RS11750	COG0436	Aminotransferase
LOH54_RS11765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LOH54_RS11770	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LOH54_RS11775	COG0254	rRNA binding
LOH54_RS11795	COG0303	'Molybdopterin
LOH54_RS11800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LOH54_RS11820	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LOH54_RS11825	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LOH54_RS11845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LOH54_RS11865	COG0069	glutamate synthase activity
LOH54_RS11880	COG0203	ribosomal protein L17
LOH54_RS11885	COG0202	RNA polymerase activity
LOH54_RS11890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LOH54_RS11895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LOH54_RS11900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LOH54_RS11905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LOH54_RS11930	COG2205	protein histidine kinase activity
LOH54_RS11955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LOH54_RS11980	COG3706	GGDEF domain
LOH54_RS11995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LOH54_RS12000	COG0024	Methionine aminopeptidase
LOH54_RS12005	COG0201	protein transport
LOH54_RS12010	COG0200	Binds to the 23S rRNA
LOH54_RS12015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LOH54_RS12020	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LOH54_RS12030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LOH54_RS12035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LOH54_RS12040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LOH54_RS12045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LOH54_RS12050	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LOH54_RS12055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LOH54_RS12060	COG0255	Belongs to the universal ribosomal protein uL29 family
LOH54_RS12065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LOH54_RS12070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LOH54_RS12075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LOH54_RS12080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LOH54_RS12085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LOH54_RS12090	COG0089	rRNA binding
LOH54_RS12095	COG0088	Forms part of the polypeptide exit tunnel
LOH54_RS12100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LOH54_RS12105	COG0051	transcription antitermination factor activity, RNA binding
LOH54_RS12115	COG5001	Diguanylate cyclase
LOH54_RS12115	COG3300	MHYT domain
LOH54_RS12120	COG2010	Cytochrome c
LOH54_RS12135	COG1136	(ABC) transporter
LOH54_RS12140	COG1136	(ABC) transporter
LOH54_RS12140	COG0577	efflux transmembrane transporter activity
LOH54_RS12155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LOH54_RS12200	COG0129	dihydroxy-acid dehydratase activity
LOH54_RS12205	COG1086	Polysaccharide biosynthesis protein
LOH54_RS12210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LOH54_RS12225	COG1215	transferase activity, transferring glycosyl groups
LOH54_RS12250	COG1216	Glycosyl transferase, family 2
LOH54_RS12275	COG0438	transferase activity, transferring glycosyl groups
LOH54_RS12290	COG0367	asparagine synthase
LOH54_RS12320	COG1393	Belongs to the ArsC family
LOH54_RS12330	COG0717	Belongs to the dCTP deaminase family
LOH54_RS12340	COG0439	Biotin carboxylase
LOH54_RS12370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LOH54_RS12375	COG0280	phosphate acetyltransferase
LOH54_RS12375	COG0281	malic enzyme
LOH54_RS12380	COG2902	Dehydrogenase
LOH54_RS12385	COG3300	MHYT domain
LOH54_RS12385	COG5001	Diguanylate cyclase
LOH54_RS12390	COG1858	cytochrome C peroxidase
LOH54_RS12395	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
LOH54_RS12405	COG0314	molybdopterin synthase activity
LOH54_RS12410	COG0303	'Molybdopterin
LOH54_RS12415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LOH54_RS12420	COG0517	IMP dehydrogenase activity
LOH54_RS12420	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LOH54_RS12425	COG1187	pseudouridine synthase activity
LOH54_RS12440	COG2814	Major facilitator Superfamily
LOH54_RS12445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LOH54_RS12445	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LOH54_RS12450	COG0504	CTP synthase activity
LOH54_RS12465	COG2814	Major facilitator Superfamily
LOH54_RS12480	COG0668	transmembrane transport
LOH54_RS12485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LOH54_RS12495	COG0746	molybdenum cofactor guanylyltransferase activity
LOH54_RS12500	COG0315	cyclic pyranopterin monophosphate synthase activity
LOH54_RS12530	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LOH54_RS12570	COG2067	long-chain fatty acid transport protein
LOH54_RS12600	COG0670	Belongs to the BI1 family
LOH54_RS12605	COG0352	thiamine-phosphate diphosphorylase activity
LOH54_RS12615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LOH54_RS12620	COG1121	(ABC) transporter
LOH54_RS12630	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LOH54_RS12640	COG0233	cytoplasmic translational termination
LOH54_RS12645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LOH54_RS12650	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LOH54_RS12655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LOH54_RS12670	COG0375	protein maturation
LOH54_RS12675	COG0309	Hydrogenase expression formation protein (HypE)
LOH54_RS12685	COG0298	carbon dioxide binding
LOH54_RS12690	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LOH54_RS12710	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LOH54_RS12715	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LOH54_RS12725	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LOH54_RS12730	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LOH54_RS12745	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LOH54_RS12750	COG2895	sulfate adenylyltransferase (ATP) activity
LOH54_RS12755	COG0175	sulfate reduction
LOH54_RS12760	COG0175	sulfate reduction
LOH54_RS12795	COG0107	imidazoleglycerol-phosphate synthase activity
LOH54_RS12810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LOH54_RS12835	COG0564	pseudouridine synthase activity
LOH54_RS12840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LOH54_RS12845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LOH54_RS12860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LOH54_RS12865	COG1022	Amp-dependent synthetase and ligase
LOH54_RS12875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LOH54_RS12880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LOH54_RS12885	COG1217	gtp-binding protein TYPA
LOH54_RS12890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LOH54_RS12905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group