locus-tag	class	description
HUE87_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUE87_RS00010	COG0592	DNA-directed DNA polymerase activity
HUE87_RS00015	COG0187	DNA topoisomerase II activity
HUE87_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HUE87_RS00030	COG0617	tRNA 3'-terminal CCA addition
HUE87_RS00035	COG1217	gtp-binding protein TYPA
HUE87_RS00045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUE87_RS00050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUE87_RS00080	COG0242	peptide deformylase activity
HUE87_RS00085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUE87_RS00120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUE87_RS00125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUE87_RS00130	COG0534	Mate efflux family protein
HUE87_RS00140	COG0688	phosphatidylethanolamine metabolic process
HUE87_RS00145	COG0358	DNA primase activity
HUE87_RS00155	COG0513	Belongs to the DEAD box helicase family
HUE87_RS00160	COG0482	sulfurtransferase activity
HUE87_RS00180	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HUE87_RS00190	COG1749	Flagellar hook protein flgE
HUE87_RS00195	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HUE87_RS00200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUE87_RS00205	COG1238	metal cluster binding
HUE87_RS00210	COG2205	protein histidine kinase activity
HUE87_RS00215	COG1053	succinate dehydrogenase
HUE87_RS00225	COG1666	GTP binding
HUE87_RS00250	COG5001	Diguanylate cyclase
HUE87_RS00260	COG1032	radical SAM domain protein
HUE87_RS00265	COG2814	Major facilitator Superfamily
HUE87_RS00275	COG0668	transmembrane transport
HUE87_RS00295	COG3852	Histidine kinase
HUE87_RS00300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUE87_RS00310	COG3746	phosphate-selective porin O and P
HUE87_RS00340	COG1592	Rubrerythrin
HUE87_RS00350	COG0071	Belongs to the small heat shock protein (HSP20) family
HUE87_RS00360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE87_RS00360	COG0574	Belongs to the PEP-utilizing enzyme family
HUE87_RS00370	COG3706	GGDEF domain
HUE87_RS00380	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUE87_RS00385	COG0406	alpha-ribazole phosphatase activity
HUE87_RS00400	COG5001	Diguanylate cyclase
HUE87_RS00400	COG4251	negative regulation of phosphorylation
HUE87_RS00400	COG2203	Gaf domain
HUE87_RS00400	COG3706	GGDEF domain
HUE87_RS00405	COG1492	cobalamin metabolic process
HUE87_RS00420	COG1944	ATP diphosphatase activity
HUE87_RS00425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUE87_RS00430	COG1120	ATPase activity
HUE87_RS00460	COG0575	Belongs to the CDS family
HUE87_RS00465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUE87_RS00470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUE87_RS00475	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HUE87_RS00490	COG0642	Histidine kinase
HUE87_RS00495	COG0745	RESPONSE REGULATOR receiver
HUE87_RS00525	COG0840	transmembrane signaling receptor activity
HUE87_RS00545	COG2259	Doxx family
HUE87_RS00560	COG1322	Protein conserved in bacteria
HUE87_RS00575	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE87_RS00595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE87_RS00605	COG4895	conserved protein (DUF2196)
HUE87_RS00610	COG0513	Belongs to the DEAD box helicase family
HUE87_RS00615	COG1451	nucleotide metabolic process
HUE87_RS00620	COG0488	(ABC) transporter
HUE87_RS00630	COG2353	YceI-like domain
HUE87_RS00650	COG2183	response to ionizing radiation
HUE87_RS00655	COG3706	GGDEF domain
HUE87_RS00680	COG0745	RESPONSE REGULATOR receiver
HUE87_RS00685	COG0642	Histidine kinase
HUE87_RS00720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUE87_RS00730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUE87_RS00730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUE87_RS00740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUE87_RS00760	COG0288	reversible hydration of carbon dioxide
HUE87_RS00765	COG0367	asparagine synthase
HUE87_RS00775	COG2239	Acts as a magnesium transporter
HUE87_RS00780	COG4536	flavin adenine dinucleotide binding
HUE87_RS00800	COG1301	dicarboxylic acid transport
HUE87_RS00805	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUE87_RS00805	COG2199	diguanylate cyclase activity
HUE87_RS00830	COG0745	RESPONSE REGULATOR receiver
HUE87_RS00835	COG0426	domain, Protein
HUE87_RS00835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUE87_RS00840	COG1648	precorrin-2 dehydrogenase activity
HUE87_RS00840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUE87_RS00845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUE87_RS00845	COG1648	precorrin-2 dehydrogenase activity
HUE87_RS00860	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HUE87_RS00865	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUE87_RS00870	COG3347	Dehydrogenase
HUE87_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
HUE87_RS00880	COG1115	amino acid carrier protein
HUE87_RS00935	COG0166	Belongs to the GPI family
HUE87_RS00945	COG0205	6-phosphofructokinase activity
HUE87_RS00955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUE87_RS00965	COG1449	Belongs to the glycosyl hydrolase 57 family
HUE87_RS00975	COG0297	glycogen (starch) synthase activity
HUE87_RS00980	COG1940	carbohydrate kinase activity
HUE87_RS00985	COG0297	glycogen (starch) synthase activity
HUE87_RS00990	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUE87_RS00995	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUE87_RS01005	COG0314	molybdopterin synthase activity
HUE87_RS01010	COG0303	'Molybdopterin
HUE87_RS01025	COG0745	RESPONSE REGULATOR receiver
HUE87_RS01030	COG0642	Histidine kinase
HUE87_RS01050	COG3258	Cytochrome c
HUE87_RS01080	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUE87_RS01090	COG0051	transcription antitermination factor activity, RNA binding
HUE87_RS01095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUE87_RS01100	COG0088	Forms part of the polypeptide exit tunnel
HUE87_RS01105	COG0089	rRNA binding
HUE87_RS01110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUE87_RS01115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUE87_RS01120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUE87_RS01125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUE87_RS01130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUE87_RS01135	COG0255	Belongs to the universal ribosomal protein uL29 family
HUE87_RS01140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUE87_RS01145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUE87_RS01150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUE87_RS01155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUE87_RS01160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUE87_RS01165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUE87_RS01170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUE87_RS01175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUE87_RS01180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUE87_RS01185	COG0200	Binds to the 23S rRNA
HUE87_RS01190	COG0201	protein transport
HUE87_RS01195	COG0024	Methionine aminopeptidase
HUE87_RS01200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUE87_RS01215	COG2169	Transcriptional regulator
HUE87_RS01215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUE87_RS01230	COG0133	tryptophan synthase activity
HUE87_RS01280	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUE87_RS01285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUE87_RS01290	COG0640	Transcriptional regulator
HUE87_RS01320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUE87_RS01325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUE87_RS01330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUE87_RS01335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUE87_RS01340	COG0202	RNA polymerase activity
HUE87_RS01345	COG0203	ribosomal protein L17
HUE87_RS01365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUE87_RS01375	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUE87_RS01380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUE87_RS01395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUE87_RS01410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUE87_RS01415	COG3706	GGDEF domain
HUE87_RS01435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE87_RS01450	COG3022	response to hydroperoxide
HUE87_RS01475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUE87_RS01480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUE87_RS01495	COG0250	Participates in transcription elongation, termination and antitermination
HUE87_RS01500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUE87_RS01505	COG0081	regulation of translation
HUE87_RS01510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUE87_RS01515	COG0222	ribosome binding
HUE87_RS01520	COG0085	RNA polymerase activity
HUE87_RS01525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUE87_RS01530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUE87_RS01535	COG0049	tRNA binding
HUE87_RS01540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUE87_RS01565	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUE87_RS01570	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUE87_RS01585	COG1558	bacterial-type flagellum-dependent cell motility
HUE87_RS01590	COG1815	bacterial-type flagellum-dependent cell motility
HUE87_RS01605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUE87_RS01615	COG0739	heme binding
HUE87_RS01625	COG0277	FAD linked oxidase domain protein
HUE87_RS01630	COG1295	ribonuclease BN
HUE87_RS01635	COG2333	competence protein COMEC
HUE87_RS01635	COG0658	competence protein
HUE87_RS01640	COG0305	Participates in initiation and elongation during chromosome replication
HUE87_RS01645	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUE87_RS01650	COG2199	diguanylate cyclase activity
HUE87_RS01650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUE87_RS01665	COG5002	protein histidine kinase activity
HUE87_RS01670	COG2957	Belongs to the agmatine deiminase family
HUE87_RS01675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUE87_RS01690	COG0357	Ribosomal RNA small subunit methyltransferase G
HUE87_RS01695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUE87_RS01700	COG0113	porphobilinogen synthase activity
HUE87_RS01705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUE87_RS01725	COG1981	membrane
HUE87_RS01730	COG1160	GTP binding
HUE87_RS01745	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HUE87_RS01750	COG0784	Response regulator, receiver
HUE87_RS01750	COG3437	response regulator, receiver
HUE87_RS01760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HUE87_RS01785	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUE87_RS01790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUE87_RS01800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUE87_RS01805	COG0612	Peptidase, M16
HUE87_RS01810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUE87_RS01815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUE87_RS01840	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HUE87_RS01845	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUE87_RS01850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUE87_RS01855	COG0745	RESPONSE REGULATOR receiver
HUE87_RS01875	COG0322	excinuclease ABC activity
HUE87_RS01890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUE87_RS01895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUE87_RS01900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUE87_RS01900	COG0519	Catalyzes the synthesis of GMP from XMP
HUE87_RS01920	COG5002	protein histidine kinase activity
HUE87_RS01935	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HUE87_RS01945	COG1185	polyribonucleotide nucleotidyltransferase activity
HUE87_RS01950	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUE87_RS01960	COG3706	GGDEF domain
HUE87_RS01970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUE87_RS01985	COG0210	DNA helicase
HUE87_RS01990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUE87_RS01995	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HUE87_RS02000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUE87_RS02005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUE87_RS02010	COG0739	heme binding
HUE87_RS02015	COG0457	Tetratricopeptide repeat
HUE87_RS02020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUE87_RS02030	COG1519	Transferase
HUE87_RS02035	COG0564	pseudouridine synthase activity
HUE87_RS02040	COG2827	Endonuclease containing a URI domain
HUE87_RS02045	COG1671	Belongs to the UPF0178 family
HUE87_RS02050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUE87_RS02055	COG0228	four-way junction DNA binding
HUE87_RS02065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUE87_RS02070	COG0336	Belongs to the RNA methyltransferase TrmD family
HUE87_RS02075	COG0335	large ribosomal subunit rRNA binding
HUE87_RS02120	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HUE87_RS02125	COG0542	response to heat
HUE87_RS02130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUE87_RS02135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUE87_RS02140	COG0540	Belongs to the ATCase OTCase family
HUE87_RS02145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUE87_RS02160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUE87_RS02170	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUE87_RS02175	COG0193	aminoacyl-tRNA hydrolase activity
HUE87_RS02185	COG0019	diaminopimelate decarboxylase activity
HUE87_RS02195	COG1605	Chorismate mutase
HUE87_RS02195	COG0077	Prephenate dehydratase
HUE87_RS02200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUE87_RS02205	COG1766	The M ring may be actively involved in energy transduction
HUE87_RS02210	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE87_RS02220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUE87_RS02235	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HUE87_RS02245	COG3787	Belongs to the UPF0306 family
HUE87_RS02255	COG1132	(ABC) transporter
HUE87_RS02270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUE87_RS02275	COG0204	Acyl-transferase
HUE87_RS02285	COG0047	phosphoribosylformylglycinamidine synthase activity
HUE87_RS02290	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUE87_RS02295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUE87_RS02300	COG0793	Belongs to the peptidase S41A family
HUE87_RS02325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUE87_RS02350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUE87_RS02355	COG0306	phosphate transporter
HUE87_RS02360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUE87_RS02370	COG0776	regulation of translation
HUE87_RS02410	COG2226	methyltransferase
HUE87_RS02420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUE87_RS02425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUE87_RS02440	COG0542	response to heat
HUE87_RS02450	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUE87_RS02455	COG0594	ribonuclease P activity
HUE87_RS02460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUE87_RS02465	COG0706	membrane insertase activity
HUE87_RS02475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUE87_RS02480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUE87_RS02500	COG0159	tryptophan synthase activity
HUE87_RS02510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUE87_RS02515	COG2255	four-way junction helicase activity
HUE87_RS02520	COG0628	permease
HUE87_RS02535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUE87_RS02540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUE87_RS02545	COG0745	RESPONSE REGULATOR receiver
HUE87_RS02550	COG2264	protein methyltransferase activity
HUE87_RS02555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE87_RS02560	COG0688	phosphatidylethanolamine metabolic process
HUE87_RS02590	COG1607	acyl-coa hydrolase
HUE87_RS02605	COG3273	potassium ion transport
HUE87_RS02605	COG0471	metal ion transport
HUE87_RS02620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUE87_RS02630	COG0560	Phosphoserine phosphatase
HUE87_RS02645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUE87_RS02730	COG0629	single-stranded DNA binding
HUE87_RS02735	COG0360	Binds together with S18 to 16S ribosomal RNA
HUE87_RS02740	COG2861	carbohydrate metabolic process
HUE87_RS02755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUE87_RS02760	COG0805	protein transport
HUE87_RS02765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUE87_RS02770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUE87_RS02775	COG0494	nUDIX hydrolase
HUE87_RS02780	COG0527	aspartate kinase activity
HUE87_RS02795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUE87_RS02805	COG0443	Heat shock 70 kDa protein
HUE87_RS02810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUE87_RS02825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUE87_RS02830	COG0138	bifunctional purine biosynthesis protein purh
HUE87_RS02835	COG0484	heat shock protein binding
HUE87_RS02845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUE87_RS02860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUE87_RS02870	COG0742	ribosomal rna small subunit methyltransferase
HUE87_RS02875	COG1706	bacterial-type flagellum-dependent cell motility
HUE87_RS02880	COG3951	Flagellar rod assembly protein muramidase FlgJ
HUE87_RS02895	COG1256	bacterial-type flagellum assembly
HUE87_RS02895	COG4786	Flagellar basal body rod
HUE87_RS02895	COG1256	bacterial-type flagellum assembly
HUE87_RS02895	COG4786	Flagellar basal body rod
HUE87_RS02900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE87_RS02905	COG0512	Glutamine amidotransferase of anthranilate synthase
HUE87_RS02950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUE87_RS02980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE87_RS02985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUE87_RS02985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUE87_RS03040	COG0438	transferase activity, transferring glycosyl groups
HUE87_RS03050	COG0110	maltose O-acetyltransferase activity
HUE87_RS03070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE87_RS03080	COG1132	(ABC) transporter
HUE87_RS03085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUE87_RS03090	COG0247	lactate metabolic process
HUE87_RS03095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUE87_RS03105	COG0513	Belongs to the DEAD box helicase family
HUE87_RS03110	COG0564	pseudouridine synthase activity
HUE87_RS03135	COG1278	Cold shock
HUE87_RS03150	COG2204	response regulator
HUE87_RS03155	COG4191	Histidine kinase
HUE87_RS03160	COG2201	protein-glutamate methylesterase activity
HUE87_RS03210	COG1136	(ABC) transporter
HUE87_RS03220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUE87_RS03225	COG0459	protein refolding
HUE87_RS03230	COG0500	methyltransferase
HUE87_RS03245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HUE87_RS03260	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HUE87_RS03265	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HUE87_RS03280	COG1309	transcriptional regulator
HUE87_RS03300	COG0848	biopolymer transport protein
HUE87_RS03305	COG0811	peptide transport
HUE87_RS03320	COG0418	dihydroorotase activity
HUE87_RS03335	COG0439	Biotin carboxylase
HUE87_RS03340	COG0308	aminopeptidase N
HUE87_RS03355	COG0242	peptide deformylase activity
HUE87_RS03365	COG2197	response regulator
HUE87_RS03380	COG0643	Histidine kinase
HUE87_RS03380	COG2198	Histidine kinase
HUE87_RS03385	COG0840	transmembrane signaling receptor activity
HUE87_RS03390	COG0835	chemotaxis
HUE87_RS03395	COG0784	Response regulator, receiver
HUE87_RS03395	COG0835	chemotaxis
HUE87_RS03405	COG2201	protein-glutamate methylesterase activity
HUE87_RS03435	COG2201	protein-glutamate methylesterase activity
HUE87_RS03440	COG5002	protein histidine kinase activity
HUE87_RS03440	COG5001	Diguanylate cyclase
HUE87_RS03450	COG2201	protein-glutamate methylesterase activity
HUE87_RS03460	COG0745	RESPONSE REGULATOR receiver
HUE87_RS03465	COG3437	response regulator, receiver
HUE87_RS03505	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUE87_RS03510	COG1979	alcohol dehydrogenase
HUE87_RS03515	COG1733	regulation of RNA biosynthetic process
HUE87_RS03520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUE87_RS03595	COG0731	radical SAM domain protein
HUE87_RS03600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUE87_RS03610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUE87_RS03615	COG2204	response regulator
HUE87_RS03635	COG0004	ammonium transporteR
HUE87_RS03645	COG0004	ammonium transporteR
HUE87_RS03685	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUE87_RS03690	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUE87_RS03690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUE87_RS03690	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUE87_RS03690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUE87_RS03700	COG1144	Oxidoreductase
HUE87_RS03705	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUE87_RS03715	COG2801	Transposase and inactivated derivatives
HUE87_RS03745	COG3002	Belongs to the UPF0753 family
HUE87_RS03755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUE87_RS03765	COG1144	Oxidoreductase
HUE87_RS03775	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUE87_RS03780	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUE87_RS03810	COG2304	oxidoreductase activity
HUE87_RS03860	COG0714	Associated with various cellular activities
HUE87_RS03880	COG2304	oxidoreductase activity
HUE87_RS03890	COG0287	Prephenate dehydrogenase
HUE87_RS03895	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUE87_RS03915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUE87_RS03955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUE87_RS03960	COG2205	protein histidine kinase activity
HUE87_RS03975	COG4584	PFAM Integrase catalytic
HUE87_RS03980	COG1484	DNA-dependent DNA replication
HUE87_RS04035	COG0582	viral genome integration into host DNA
HUE87_RS04045	COG0745	RESPONSE REGULATOR receiver
HUE87_RS04055	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUE87_RS04070	COG0157	Belongs to the NadC ModD family
HUE87_RS04075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUE87_RS04090	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HUE87_RS04100	COG0083	homoserine kinase activity
HUE87_RS04110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUE87_RS04115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUE87_RS04120	COG0779	Required for maturation of 30S ribosomal subunits
HUE87_RS04125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUE87_RS04125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUE87_RS04130	COG2226	methyltransferase
HUE87_RS04135	COG1570	exodeoxyribonuclease VII activity
HUE87_RS04150	COG0840	transmembrane signaling receptor activity
HUE87_RS04155	COG0402	S-adenosylhomocysteine deaminase activity
HUE87_RS04160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUE87_RS04165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUE87_RS04170	COG1419	protein localization to endoplasmic reticulum
HUE87_RS04175	COG0455	bacterial-type flagellum organization
HUE87_RS04185	COG1191	sigma factor activity
HUE87_RS04195	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE87_RS04195	COG1776	CheC inhibitor of MCP methylation
HUE87_RS04200	COG1611	Belongs to the LOG family
HUE87_RS04205	COG0482	sulfurtransferase activity
HUE87_RS04230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUE87_RS04240	COG0339	signal peptide processing
HUE87_RS04250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUE87_RS04270	COG1116	anion transmembrane transporter activity
HUE87_RS04280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUE87_RS04280	COG1116	anion transmembrane transporter activity
HUE87_RS04285	COG0243	molybdopterin cofactor binding
HUE87_RS04305	COG0748	coenzyme F420 binding
HUE87_RS04320	COG2066	Belongs to the glutaminase family
HUE87_RS04335	COG0500	methyltransferase
HUE87_RS04340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUE87_RS04345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUE87_RS04350	COG0513	Belongs to the DEAD box helicase family
HUE87_RS04390	COG1902	pentaerythritol trinitrate reductase activity
HUE87_RS04395	COG0494	nUDIX hydrolase
HUE87_RS04410	COG3256	nitric oxide reductase
HUE87_RS04415	COG2010	Cytochrome c
HUE87_RS04420	COG1959	2 iron, 2 sulfur cluster binding
HUE87_RS04430	COG2703	oxygen carrier activity
HUE87_RS04440	COG0528	UMP kinase activity
HUE87_RS04445	COG1758	RNA polymerase activity
HUE87_RS04455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUE87_RS04465	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUE87_RS04470	COG2404	hydrolase activity, acting on ester bonds
HUE87_RS04475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUE87_RS04480	COG1959	2 iron, 2 sulfur cluster binding
HUE87_RS04485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUE87_RS04490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HUE87_RS04495	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUE87_RS04510	COG0134	indole-3-glycerol-phosphate synthase activity
HUE87_RS04520	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HUE87_RS04530	COG2199	diguanylate cyclase activity
HUE87_RS04530	COG2200	EAL domain
HUE87_RS04540	COG0659	secondary active sulfate transmembrane transporter activity
HUE87_RS04545	COG0525	valine-tRNA ligase activity
HUE87_RS04555	COG2199	diguanylate cyclase activity
HUE87_RS04580	COG1704	LemA family
HUE87_RS04585	COG2081	HI0933 family
HUE87_RS04590	COG1193	negative regulation of DNA recombination
HUE87_RS04610	COG0436	Aminotransferase
HUE87_RS04620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUE87_RS04630	COG1722	exodeoxyribonuclease VII activity
HUE87_RS04645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUE87_RS04655	COG1714	RDD family
HUE87_RS04660	COG1716	ATPase activity
HUE87_RS04660	COG5001	Diguanylate cyclase
HUE87_RS04665	COG0516	GMP reductase activity
HUE87_RS04665	COG0517	IMP dehydrogenase activity
HUE87_RS04680	COG0154	amidase activity
HUE87_RS04685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUE87_RS04690	COG1546	Belongs to the CinA family
HUE87_RS04690	COG1058	Belongs to the CinA family
HUE87_RS04725	COG2703	oxygen carrier activity
HUE87_RS04730	COG0772	Belongs to the SEDS family
HUE87_RS04735	COG0564	pseudouridine synthase activity
HUE87_RS04745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUE87_RS04750	COG2884	Cell division ATP-binding protein ftsE
HUE87_RS04765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUE87_RS04775	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUE87_RS04780	COG0745	RESPONSE REGULATOR receiver
HUE87_RS04785	COG0275	rRNA processing
HUE87_RS04810	COG1686	Belongs to the peptidase S11 family
HUE87_RS04820	COG1027	Aspartate ammonia-lyase
HUE87_RS04845	COG0745	RESPONSE REGULATOR receiver
HUE87_RS04855	COG0736	holo-[acyl-carrier-protein] synthase activity
HUE87_RS04860	COG1580	Controls the rotational direction of flagella during chemotaxis
HUE87_RS04870	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUE87_RS04875	COG0840	transmembrane signaling receptor activity
HUE87_RS04880	COG0552	protein localization to endoplasmic reticulum
HUE87_RS04885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUE87_RS04895	COG1418	mRNA catabolic process
HUE87_RS04910	COG0500	methyltransferase
HUE87_RS04915	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUE87_RS04915	COG2050	protein possibly involved in aromatic compounds catabolism
HUE87_RS04930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUE87_RS04935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUE87_RS04940	COG1663	tetraacyldisaccharide 4'-kinase activity
HUE87_RS04945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUE87_RS04970	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUE87_RS04975	COG0442	prolyl-tRNA aminoacylation
HUE87_RS04990	COG0181	hydroxymethylbilane synthase activity
HUE87_RS04995	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUE87_RS05005	COG0165	Argininosuccinate lyase
HUE87_RS05020	COG0537	adenosine 5'-monophosphoramidase activity
HUE87_RS05025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUE87_RS05030	COG0072	phenylalanine-tRNA ligase activity
HUE87_RS05030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUE87_RS05035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUE87_RS05040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUE87_RS05045	COG1185	polyribonucleotide nucleotidyltransferase activity
HUE87_RS05045	COG0539	negative regulation of cytoplasmic translation
HUE87_RS05055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE87_RS05110	COG0784	Response regulator, receiver
HUE87_RS05110	COG3437	response regulator, receiver
HUE87_RS05125	COG2954	triphosphatase activity
HUE87_RS05155	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUE87_RS05160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUE87_RS05175	COG0390	transport system, permease component
HUE87_RS05190	COG1408	metallophosphoesterase
HUE87_RS05200	COG0778	Nitroreductase
HUE87_RS05220	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HUE87_RS05225	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUE87_RS05240	COG5002	protein histidine kinase activity
HUE87_RS05245	COG1331	Highly conserved protein containing a thioredoxin domain
HUE87_RS05250	COG3153	acetyltransferase
HUE87_RS05250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUE87_RS05255	COG1012	belongs to the aldehyde dehydrogenase family
HUE87_RS05260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUE87_RS05265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUE87_RS05270	COG3123	guanosine phosphorylase activity
HUE87_RS05280	COG3706	GGDEF domain
HUE87_RS05285	COG2239	Acts as a magnesium transporter
HUE87_RS05305	COG2326	polyphosphate kinase activity
HUE87_RS05320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUE87_RS05345	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUE87_RS05355	COG2354	Protein conserved in bacteria
HUE87_RS05385	COG1643	Atp-dependent helicase
HUE87_RS05400	COG4232	protein-disulfide reductase activity
HUE87_RS05420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUE87_RS05425	COG0343	queuine tRNA-ribosyltransferase activity
HUE87_RS05435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUE87_RS05455	COG0587	DNA-directed DNA polymerase activity
HUE87_RS05460	COG1362	aminopeptidase activity
HUE87_RS05465	COG0642	Histidine kinase
HUE87_RS05480	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUE87_RS05485	COG1333	cytochrome c biogenesis protein
HUE87_RS05485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUE87_RS05495	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUE87_RS05500	COG0546	phosphoglycolate phosphatase activity
HUE87_RS05520	COG2197	response regulator
HUE87_RS05525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUE87_RS05565	COG0824	Thioesterase
HUE87_RS05620	COG1002	Type II restriction enzyme, methylase subunits
HUE87_RS05630	COG1061	Type III restriction enzyme res subunit
HUE87_RS05635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUE87_RS05640	COG0420	3'-5' exonuclease activity
HUE87_RS05645	COG0419	ATPase involved in DNA repair
HUE87_RS05700	COG3287	FIST C domain
HUE87_RS05700	COG2199	diguanylate cyclase activity
HUE87_RS05700	COG2200	EAL domain
HUE87_RS05725	COG0352	thiamine-phosphate diphosphorylase activity
HUE87_RS05740	COG2081	HI0933 family
HUE87_RS05755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUE87_RS05760	COG0750	zinc metalloprotease
HUE87_RS05770	COG2199	diguanylate cyclase activity
HUE87_RS05770	COG2200	EAL domain
HUE87_RS05770	COG3287	FIST C domain
HUE87_RS05800	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUE87_RS05820	COG5000	phosphorelay sensor kinase activity
HUE87_RS05835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUE87_RS05840	COG0101	tRNA pseudouridine synthase activity
HUE87_RS05850	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HUE87_RS05855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUE87_RS05865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUE87_RS05870	COG0475	glutathione-regulated potassium exporter activity
HUE87_RS05875	COG0753	catalase activity
HUE87_RS05890	COG3021	interspecies interaction between organisms
HUE87_RS05900	COG1073	alpha beta
HUE87_RS05920	COG2226	methyltransferase
HUE87_RS05925	COG1254	Belongs to the acylphosphatase family
HUE87_RS05940	COG1252	NADH dehydrogenase
HUE87_RS05965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUE87_RS05970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUE87_RS05980	COG1338	Plays a role in the flagellum-specific transport system
HUE87_RS05985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUE87_RS06005	COG0835	chemotaxis
HUE87_RS06010	COG0840	transmembrane signaling receptor activity
HUE87_RS06020	COG0835	chemotaxis
HUE87_RS06025	COG0840	transmembrane signaling receptor activity
HUE87_RS06035	COG0643	Histidine kinase
HUE87_RS06035	COG2198	Histidine kinase
HUE87_RS06045	COG5002	protein histidine kinase activity
HUE87_RS06050	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HUE87_RS06055	COG2201	protein-glutamate methylesterase activity
HUE87_RS06075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUE87_RS06085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUE87_RS06090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE87_RS06095	COG0702	epimerase
HUE87_RS06105	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUE87_RS06115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUE87_RS06120	COG1053	succinate dehydrogenase
HUE87_RS06130	COG0708	Exodeoxyribonuclease III
HUE87_RS06135	COG2048	Heterodisulfide reductase, subunit B
HUE87_RS06165	COG0585	pseudouridine synthase activity
HUE87_RS06180	COG0012	GTP binding
HUE87_RS06200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUE87_RS06205	COG0133	tryptophan synthase activity
HUE87_RS06210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUE87_RS06220	COG0698	ribose 5-phosphate isomerase
HUE87_RS06225	COG1994	Peptidase M50
HUE87_RS06230	COG0681	Belongs to the peptidase S26 family
HUE87_RS06235	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUE87_RS06255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUE87_RS06275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUE87_RS06280	COG4786	Flagellar basal body rod
HUE87_RS06285	COG4786	Flagellar basal body rod
HUE87_RS06295	COG0189	ligase activity
HUE87_RS06310	COG0066	3-isopropylmalate dehydratase activity
HUE87_RS06315	COG0473	3-isopropylmalate dehydrogenase activity
HUE87_RS06330	COG0788	formyltetrahydrofolate deformylase activity
HUE87_RS06360	COG2171	N-acyltransferase activity
HUE87_RS06390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HUE87_RS06405	COG0513	Belongs to the DEAD box helicase family
HUE87_RS06420	COG0563	adenylate kinase activity
HUE87_RS06430	COG0563	adenylate kinase activity
HUE87_RS06435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUE87_RS06440	COG2203	Gaf domain
HUE87_RS06440	COG3706	GGDEF domain
HUE87_RS06440	COG5001	Diguanylate cyclase
HUE87_RS06440	COG4251	negative regulation of phosphorylation
HUE87_RS06445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUE87_RS06455	COG1528	Iron-storage protein
HUE87_RS06460	COG0493	'glutamate synthase
HUE87_RS06485	COG0497	DNA recombination
HUE87_RS06490	COG0084	hydrolase, TatD family'
HUE87_RS06500	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUE87_RS06505	COG0131	Imidazoleglycerol-phosphate dehydratase
HUE87_RS06510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HUE87_RS06525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUE87_RS06530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUE87_RS06535	COG0768	penicillin binding
HUE87_RS06545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUE87_RS06555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUE87_RS06570	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUE87_RS06585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUE87_RS06585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUE87_RS06595	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HUE87_RS06620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUE87_RS06640	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUE87_RS06655	COG2703	oxygen carrier activity
HUE87_RS06705	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUE87_RS06710	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUE87_RS06710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUE87_RS06720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUE87_RS06725	COG0045	succinate-CoA ligase (ADP-forming) activity
HUE87_RS06730	COG0114	fumarate hydratase activity
HUE87_RS06735	COG0039	L-malate dehydrogenase activity
HUE87_RS06745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUE87_RS06760	COG0653	protein targeting
HUE87_RS06770	COG1049	propionate catabolic process, 2-methylcitrate cycle
HUE87_RS06780	COG1674	ftsk spoiiie
HUE87_RS06780	COG1196	nuclear chromosome segregation
HUE87_RS06800	COG0163	prenyltransferase activity
HUE87_RS06805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUE87_RS06810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUE87_RS06845	COG0124	histidyl-tRNA synthetase
HUE87_RS06855	COG1166	arginine decarboxylase activity
HUE87_RS06860	COG1045	serine acetyltransferase
HUE87_RS06875	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUE87_RS06880	COG0440	acetolactate synthase activity
HUE87_RS06885	COG0028	Belongs to the TPP enzyme family
HUE87_RS06895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUE87_RS06910	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HUE87_RS06915	COG1137	ATPase activity
HUE87_RS06920	COG0802	atpase or kinase
HUE87_RS06925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUE87_RS06930	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUE87_RS06935	COG2199	diguanylate cyclase activity
HUE87_RS06935	COG2200	EAL domain
HUE87_RS06935	COG3287	FIST C domain
HUE87_RS06940	COG1032	radical SAM domain protein
HUE87_RS06945	COG0318	PFAM AMP-dependent synthetase and ligase
HUE87_RS06960	COG1227	inorganic diphosphatase activity
HUE87_RS06970	COG0840	transmembrane signaling receptor activity
HUE87_RS06990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUE87_RS06995	COG0730	response to heat
HUE87_RS07005	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE87_RS07020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUE87_RS07035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HUE87_RS07045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUE87_RS07055	COG0069	glutamate synthase activity
HUE87_RS07055	COG0070	glutamate synthase
HUE87_RS07055	COG0067	glutamate synthase
HUE87_RS07065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HUE87_RS07070	COG0500	methyltransferase
HUE87_RS07110	COG1730	sister chromatid segregation
HUE87_RS07155	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HUE87_RS07160	COG3842	ATPase activity
HUE87_RS07165	COG0725	ABC transporter, periplasmic molybdate-binding protein
HUE87_RS07190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUE87_RS07200	COG0437	4 iron, 4 sulfur cluster binding
HUE87_RS07235	COG4565	transcriptional regulatory protein
HUE87_RS07240	COG0425	Belongs to the sulfur carrier protein TusA family
HUE87_RS07250	COG0709	Synthesizes selenophosphate from selenide and ATP
HUE87_RS07260	COG1921	L-seryl-tRNASec selenium transferase activity
HUE87_RS07270	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HUE87_RS07275	COG0709	Synthesizes selenophosphate from selenide and ATP
HUE87_RS07285	COG3264	Mechanosensitive ion channel
HUE87_RS07285	COG1196	nuclear chromosome segregation
HUE87_RS07310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUE87_RS07320	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUE87_RS07325	COG0632	four-way junction helicase activity
HUE87_RS07335	COG0728	peptidoglycan biosynthetic process
HUE87_RS07370	COG0215	cysteine-tRNA ligase activity
HUE87_RS07390	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUE87_RS07410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUE87_RS07420	COG0277	FAD linked oxidase domain protein
HUE87_RS07440	COG0167	dihydroorotate dehydrogenase activity
HUE87_RS07445	COG0612	Peptidase, M16
HUE87_RS07465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE87_RS07470	COG1028	Short-chain dehydrogenase reductase Sdr
HUE87_RS07500	COG1592	Rubrerythrin
HUE87_RS07515	COG0642	Histidine kinase
HUE87_RS07555	COG4974	Belongs to the 'phage' integrase family
HUE87_RS07570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUE87_RS07575	COG1393	Belongs to the ArsC family
HUE87_RS07600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUE87_RS07625	COG0243	molybdopterin cofactor binding
HUE87_RS07635	COG0784	Response regulator, receiver
HUE87_RS07635	COG0835	chemotaxis
HUE87_RS07645	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUE87_RS07650	COG3630	sodium ion export across plasma membrane
HUE87_RS07655	COG2814	Major facilitator Superfamily
HUE87_RS07675	COG0326	Molecular chaperone. Has ATPase activity
HUE87_RS07700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUE87_RS07715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUE87_RS07740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUE87_RS07765	COG1053	succinate dehydrogenase
HUE87_RS07770	COG0667	Aldo Keto reductase
HUE87_RS07790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HUE87_RS07795	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HUE87_RS07805	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HUE87_RS07835	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HUE87_RS07875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HUE87_RS07880	COG0633	Ferredoxin
HUE87_RS07900	COG0347	Belongs to the P(II) protein family
HUE87_RS07905	COG0716	FMN binding
HUE87_RS07920	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HUE87_RS07950	COG0667	Aldo Keto reductase
HUE87_RS07960	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HUE87_RS07960	COG3261	NADH dehydrogenase
HUE87_RS07980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE87_RS07985	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUE87_RS08005	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HUE87_RS08010	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HUE87_RS08015	COG1067	ATP-dependent peptidase activity
HUE87_RS08035	COG1971	Probably functions as a manganese efflux pump
HUE87_RS08040	COG5002	protein histidine kinase activity
HUE87_RS08075	COG2199	diguanylate cyclase activity
HUE87_RS08075	COG3287	FIST C domain
HUE87_RS08075	COG2200	EAL domain
HUE87_RS08080	COG0686	Belongs to the AlaDH PNT family
HUE87_RS08105	COG0745	RESPONSE REGULATOR receiver
HUE87_RS08105	COG4191	Histidine kinase
HUE87_RS08105	COG0745	RESPONSE REGULATOR receiver
HUE87_RS08105	COG4191	Histidine kinase
HUE87_RS08105	COG2205	protein histidine kinase activity
HUE87_RS08105	COG2205	protein histidine kinase activity
HUE87_RS08110	COG2202	Pas domain
HUE87_RS08110	COG2205	protein histidine kinase activity
HUE87_RS08115	COG0488	(ABC) transporter
HUE87_RS08120	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUE87_RS08125	COG3706	GGDEF domain
HUE87_RS08140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUE87_RS08145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUE87_RS08160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUE87_RS08165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUE87_RS08180	COG2853	Lipoprotein
HUE87_RS08185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUE87_RS08190	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HUE87_RS08195	COG0484	heat shock protein binding
HUE87_RS08205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUE87_RS08220	COG0849	cell division
HUE87_RS08225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUE87_RS08240	COG0577	efflux transmembrane transporter activity
HUE87_RS08240	COG1136	(ABC) transporter
HUE87_RS08265	COG2890	protein-(glutamine-N5) methyltransferase activity
HUE87_RS08270	COG0501	Belongs to the peptidase M48B family
HUE87_RS08275	COG1136	(ABC) transporter
HUE87_RS08280	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUE87_RS08300	COG0471	metal ion transport
HUE87_RS08305	COG0515	serine threonine protein kinase
HUE87_RS08305	COG2815	serine threonine protein kinase
HUE87_RS08310	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUE87_RS08320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUE87_RS08325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUE87_RS08335	COG0356	it plays a direct role in the translocation of protons across the membrane
HUE87_RS08340	COG0585	pseudouridine synthase activity
HUE87_RS08355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUE87_RS08370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUE87_RS08405	COG1459	type II secretion system
HUE87_RS08415	COG2165	general secretion pathway protein
HUE87_RS08455	COG0137	argininosuccinate synthase activity
HUE87_RS08465	COG0359	binds to the 23S rRNA
HUE87_RS08470	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HUE87_RS08530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUE87_RS08540	COG1739	Uncharacterized protein family UPF0029
HUE87_RS08545	COG0217	transcriptional regulatory protein
HUE87_RS08555	COG0037	tRNA processing
HUE87_RS08560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUE87_RS08565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUE87_RS08565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUE87_RS08570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUE87_RS08580	COG1047	Peptidyl-prolyl cis-trans
HUE87_RS08595	COG0823	Involved in the tonB-independent uptake of proteins
HUE87_RS08605	COG0848	biopolymer transport protein
HUE87_RS08610	COG0811	peptide transport
HUE87_RS08615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUE87_RS08620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUE87_RS08625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUE87_RS08630	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUE87_RS08635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUE87_RS08650	COG1475	DNA binding
HUE87_RS08655	COG1192	Involved in chromosome partitioning
HUE87_RS08660	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HUE87_RS08660	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HUE87_RS08665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUE87_RS08670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUE87_RS08675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUE87_RS08680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUE87_RS08685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUE87_RS08690	COG0375	protein maturation
HUE87_RS08695	COG0309	Hydrogenase expression formation protein (HypE)
HUE87_RS08700	COG4628	conserved protein (DUF2132)
HUE87_RS08705	COG1401	restriction endodeoxyribonuclease activity
HUE87_RS08715	COG0409	Hydrogenase expression formation protein
HUE87_RS08720	COG0298	carbon dioxide binding
HUE87_RS08725	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUE87_RS08740	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HUE87_RS08750	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HUE87_RS08755	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HUE87_RS08760	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HUE87_RS08765	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HUE87_RS08780	COG1309	transcriptional regulator
HUE87_RS08785	COG0251	oxidation-reduction process
HUE87_RS08800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE87_RS08810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUE87_RS08820	COG0745	RESPONSE REGULATOR receiver
HUE87_RS08825	COG2885	chlorophyll binding
HUE87_RS08835	COG2274	protein secretion by the type I secretion system
HUE87_RS08890	COG4974	Belongs to the 'phage' integrase family
HUE87_RS08930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUE87_RS08960	COG4969	Belongs to the N-Me-Phe pilin family
HUE87_RS09025	COG0582	viral genome integration into host DNA
HUE87_RS09065	COG0284	orotidine-5'-phosphate decarboxylase activity
HUE87_RS09070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUE87_RS09075	COG2176	DNA-directed DNA polymerase activity
HUE87_RS09085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUE87_RS09100	COG0840	transmembrane signaling receptor activity
HUE87_RS09105	COG0745	RESPONSE REGULATOR receiver
HUE87_RS09110	COG0642	Histidine kinase
HUE87_RS09115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUE87_RS09130	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUE87_RS09135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUE87_RS09140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUE87_RS09145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUE87_RS09150	COG1077	Cell shape determining protein MreB Mrl
HUE87_RS09160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUE87_RS09180	COG0754	glutathionylspermidine amidase activity
HUE87_RS09190	COG1555	photosystem II stabilization
HUE87_RS09195	COG1086	Polysaccharide biosynthesis protein
HUE87_RS09205	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
HUE87_RS09215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUE87_RS09240	COG1091	dTDP-4-dehydrorhamnose reductase activity
HUE87_RS09250	COG1086	Polysaccharide biosynthesis protein
HUE87_RS09260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE87_RS09270	COG1215	transferase activity, transferring glycosyl groups
HUE87_RS09275	COG0438	transferase activity, transferring glycosyl groups
HUE87_RS09275	COG4641	Protein conserved in bacteria
HUE87_RS09280	COG0110	maltose O-acetyltransferase activity
HUE87_RS09285	COG0275	rRNA processing
HUE87_RS09300	COG1088	dTDP-glucose 4,6-dehydratase activity
HUE87_RS09325	COG2192	nodulation
HUE87_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
HUE87_RS09335	COG1083	cytidylyl-transferase
HUE87_RS09355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUE87_RS09355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUE87_RS09360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUE87_RS09365	COG2089	acid synthase
HUE87_RS09375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUE87_RS09385	COG0166	Belongs to the GPI family
HUE87_RS09390	COG1793	dna ligase
HUE87_RS09410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUE87_RS09415	COG2860	membrane
HUE87_RS09420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUE87_RS09425	COG1070	Carbohydrate kinase
HUE87_RS09435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUE87_RS09440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUE87_RS09450	COG0489	protein tyrosine kinase activity
HUE87_RS09455	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUE87_RS09460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUE87_RS09460	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUE87_RS09465	COG0745	RESPONSE REGULATOR receiver
HUE87_RS09470	COG2046	Belongs to the sulfate adenylyltransferase family
HUE87_RS09505	COG0668	transmembrane transport
HUE87_RS09510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUE87_RS09520	COG3290	protein histidine kinase activity
HUE87_RS09520	COG0840	transmembrane signaling receptor activity
HUE87_RS09560	COG1278	Cold shock
HUE87_RS09565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUE87_RS09570	COG0280	phosphate acetyltransferase
HUE87_RS09570	COG0857	belongs to the CobB CobQ family
HUE87_RS09575	COG3012	SEC-C Motif Domain Protein
HUE87_RS09585	COG0579	oxidoreductase
HUE87_RS09590	COG0488	(ABC) transporter
HUE87_RS09610	COG4251	negative regulation of phosphorylation
HUE87_RS09610	COG5001	Diguanylate cyclase
HUE87_RS09610	COG3706	GGDEF domain
HUE87_RS09610	COG2203	Gaf domain
HUE87_RS09625	COG0243	molybdopterin cofactor binding
HUE87_RS09630	COG0437	4 iron, 4 sulfur cluster binding
HUE87_RS09635	COG0348	domain, Protein
HUE87_RS09640	COG3043	anaerobic respiration
HUE87_RS09675	COG0006	proline dipeptidase activity
HUE87_RS09690	COG1127	ABC transporter
HUE87_RS09695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUE87_RS09700	COG0835	chemotaxis
HUE87_RS09705	COG0643	Histidine kinase
HUE87_RS09705	COG0784	Response regulator, receiver
HUE87_RS09705	COG2198	Histidine kinase
HUE87_RS09710	COG0784	Response regulator, receiver
HUE87_RS09710	COG0835	chemotaxis
HUE87_RS09720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUE87_RS09750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HUE87_RS09765	COG0840	transmembrane signaling receptor activity
HUE87_RS09770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUE87_RS09775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUE87_RS09780	COG0643	Histidine kinase
HUE87_RS09780	COG2198	Histidine kinase
HUE87_RS09785	COG2201	protein-glutamate methylesterase activity
HUE87_RS09795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUE87_RS09800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUE87_RS09805	COG2205	protein histidine kinase activity
HUE87_RS09825	COG0481	GTPase activity
HUE87_RS09830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUE87_RS09835	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HUE87_RS09845	COG1692	metallophosphoesterase
HUE87_RS09850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUE87_RS09860	COG0739	heme binding
HUE87_RS09865	COG0285	dihydrofolate synthase activity
HUE87_RS09880	COG0495	leucyl-tRNA aminoacylation
HUE87_RS09890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUE87_RS09910	COG0557	exoribonuclease II activity
HUE87_RS09920	COG0840	transmembrane signaling receptor activity
HUE87_RS09920	COG3290	protein histidine kinase activity
HUE87_RS09925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUE87_RS09930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUE87_RS09935	COG1862	Preprotein translocase
HUE87_RS09940	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUE87_RS09950	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUE87_RS09955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUE87_RS09960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUE87_RS09965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUE87_RS09980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUE87_RS09985	COG0135	phosphoribosylanthranilate isomerase activity
HUE87_RS09990	COG2176	DNA-directed DNA polymerase activity
HUE87_RS09995	COG0825	malonyl-CoA metabolic process
HUE87_RS10000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUE87_RS10005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUE87_RS10015	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUE87_RS10020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUE87_RS10025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUE87_RS10055	COG0784	Response regulator, receiver
HUE87_RS10055	COG3437	response regulator, receiver
HUE87_RS10095	COG1017	nitric oxide dioxygenase activity
HUE87_RS10095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUE87_RS10125	COG4753	response regulator
HUE87_RS10125	COG2207	Transcriptional regulator
HUE87_RS10130	COG2223	nitrite transmembrane transporter activity
HUE87_RS10135	COG3290	protein histidine kinase activity
HUE87_RS10135	COG0840	transmembrane signaling receptor activity
HUE87_RS10140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUE87_RS10150	COG0556	nucleotide-excision repair
HUE87_RS10155	COG0471	metal ion transport
HUE87_RS10165	COG0415	Belongs to the DNA photolyase family
HUE87_RS10185	COG0784	Response regulator, receiver
HUE87_RS10185	COG5002	protein histidine kinase activity
HUE87_RS10185	COG2198	Histidine kinase
HUE87_RS10205	COG0556	nucleotide-excision repair
HUE87_RS10265	COG0556	nucleotide-excision repair
HUE87_RS10275	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HUE87_RS10310	COG0475	glutathione-regulated potassium exporter activity
HUE87_RS10310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUE87_RS10315	COG2081	HI0933 family
HUE87_RS10325	COG2192	nodulation
HUE87_RS10335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUE87_RS10340	COG0037	tRNA processing
HUE87_RS10370	COG2121	Domain of unknown function (DUF374)
HUE87_RS10375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUE87_RS10385	COG0195	Participates in both transcription termination and antitermination
HUE87_RS10410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUE87_RS10415	COG0149	triose-phosphate isomerase activity
HUE87_RS10420	COG0126	phosphoglycerate kinase activity
HUE87_RS10425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUE87_RS10430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUE87_RS10440	COG0840	transmembrane signaling receptor activity
HUE87_RS10445	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HUE87_RS10450	COG0642	Histidine kinase
HUE87_RS10455	COG0745	RESPONSE REGULATOR receiver
HUE87_RS10460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HUE87_RS10475	COG3290	protein histidine kinase activity
HUE87_RS10475	COG0840	transmembrane signaling receptor activity
HUE87_RS10480	COG1183	phosphatidylcholine synthase activity
HUE87_RS10490	COG0668	transmembrane transport
HUE87_RS10500	COG0513	Belongs to the DEAD box helicase family
HUE87_RS10515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUE87_RS10520	COG0416	fatty acid biosynthetic process
HUE87_RS10525	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUE87_RS10535	COG0105	UTP biosynthetic process
HUE87_RS10545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUE87_RS10555	COG0450	alkyl hydroperoxide reductase
HUE87_RS10570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE87_RS10575	COG3864	Putative metallopeptidase domain
HUE87_RS10615	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUE87_RS10625	COG4948	Mandelate Racemase Muconate Lactonizing
HUE87_RS10645	COG2176	DNA-directed DNA polymerase activity
HUE87_RS10650	COG1757	Na H antiporter
HUE87_RS10665	COG0018	arginyl-trna synthetase
HUE87_RS10670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUE87_RS10675	COG0194	GDP metabolic process
HUE87_RS10685	COG1684	flagellar biosynthetic protein fliR
HUE87_RS10690	COG1136	(ABC) transporter
HUE87_RS10695	COG1007	ATP synthesis coupled electron transport
HUE87_RS10700	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE87_RS10705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUE87_RS10710	COG0713	ATP synthesis coupled electron transport
HUE87_RS10720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE87_RS10725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUE87_RS10740	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HUE87_RS10745	COG0649	NAD binding
HUE87_RS10745	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE87_RS10750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE87_RS10755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE87_RS10760	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUE87_RS10765	COG0052	Belongs to the universal ribosomal protein uS2 family
HUE87_RS10775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUE87_RS10790	COG0586	Pfam SNARE associated Golgi protein
HUE87_RS10795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUE87_RS10800	COG0772	Belongs to the SEDS family
HUE87_RS10825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUE87_RS10835	COG1007	ATP synthesis coupled electron transport
HUE87_RS10845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUE87_RS10850	COG0713	ATP synthesis coupled electron transport
HUE87_RS10855	COG0839	Belongs to the complex I subunit 6 family
HUE87_RS10860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE87_RS10865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUE87_RS10870	COG1034	ATP synthesis coupled electron transport
HUE87_RS10890	COG0649	NAD binding
HUE87_RS10895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE87_RS10900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE87_RS10905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE87_RS10910	COG1222	aaa ATPase
HUE87_RS10920	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUE87_RS10930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUE87_RS10935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUE87_RS10955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUE87_RS10980	COG3842	ATPase activity
HUE87_RS10985	COG1252	NADH dehydrogenase
HUE87_RS11000	COG1355	regulation of microtubule-based process
HUE87_RS11005	COG3885	ferrous iron binding
HUE87_RS11005	COG2078	PFAM AMMECR1 domain protein
HUE87_RS11020	COG1090	epimerase
HUE87_RS11025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE87_RS11030	COG0752	glycyl-tRNA synthetase alpha subunit
HUE87_RS11045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUE87_RS11050	COG0826	peptidase U32
HUE87_RS11060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUE87_RS11065	COG3118	belongs to the thioredoxin family
HUE87_RS11075	COG0492	ferredoxin-NADP+ reductase activity
HUE87_RS11080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUE87_RS11085	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HUE87_RS11090	COG1242	4 iron, 4 sulfur cluster binding
HUE87_RS11105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUE87_RS11105	COG0140	phosphoribosyl-ATP diphosphatase activity
HUE87_RS11110	COG0330	HflC and HflK could
HUE87_RS11135	COG0573	inorganic phosphate transmembrane transporter activity
HUE87_RS11140	COG0581	inorganic phosphate transmembrane transporter activity
HUE87_RS11145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUE87_RS11155	COG0174	glutamine synthetase
HUE87_RS11165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUE87_RS11170	COG0745	RESPONSE REGULATOR receiver
HUE87_RS11175	COG0642	Histidine kinase
HUE87_RS11190	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HUE87_RS11195	COG4172	Belongs to the ABC transporter superfamily
HUE87_RS11200	COG0156	8-amino-7-oxononanoate synthase activity
HUE87_RS11210	COG0424	maF-like protein
HUE87_RS11220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUE87_RS11240	COG1333	cytochrome c biogenesis protein
HUE87_RS11240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUE87_RS11255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUE87_RS11255	COG1333	cytochrome c biogenesis protein
HUE87_RS11260	COG1333	cytochrome c biogenesis protein
HUE87_RS11260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUE87_RS11285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUE87_RS11325	COG1012	belongs to the aldehyde dehydrogenase family
HUE87_RS11340	COG0792	nuclease activity
HUE87_RS11345	COG3383	formate dehydrogenase (NAD+) activity
HUE87_RS11355	COG0460	homoserine dehydrogenase
HUE87_RS11360	COG0436	Aminotransferase
HUE87_RS11380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUE87_RS11385	COG0254	rRNA binding
HUE87_RS11390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUE87_RS11400	COG0303	'Molybdopterin
HUE87_RS11410	COG0602	queuosine metabolic process
HUE87_RS11415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUE87_RS11440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUE87_RS11470	COG2257	FlhB HrpN YscU SpaS Family
HUE87_RS11475	COG0514	ATP-dependent DNA helicase (RecQ)
HUE87_RS11495	COG1854	S-ribosylhomocysteine lyase activity
HUE87_RS11505	COG2201	protein-glutamate methylesterase activity
HUE87_RS11515	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUE87_RS11520	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUE87_RS11525	COG1144	Oxidoreductase
HUE87_RS11530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUE87_RS11545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUE87_RS11550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUE87_RS11555	COG1279	arginine transmembrane transporter activity
HUE87_RS11560	COG1074	ATP-dependent DNA helicase activity
HUE87_RS11600	COG3278	Belongs to the heme-copper respiratory oxidase family
HUE87_RS11605	COG0505	Belongs to the CarA family
HUE87_RS11630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUE87_RS11635	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HUE87_RS11640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUE87_RS11645	COG1968	undecaprenyl-diphosphatase activity
HUE87_RS11650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUE87_RS11660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUE87_RS11665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUE87_RS11670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUE87_RS11675	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUE87_RS11675	COG0022	dehydrogenase e1 component
HUE87_RS11680	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUE87_RS11685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUE87_RS11695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUE87_RS11700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUE87_RS11705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUE87_RS11710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUE87_RS11715	COG2814	Major facilitator Superfamily
HUE87_RS11720	COG1132	(ABC) transporter
HUE87_RS11725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUE87_RS11735	COG0129	dihydroxy-acid dehydratase activity
HUE87_RS11780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE87_RS11785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUE87_RS11790	COG1047	Peptidyl-prolyl cis-trans
HUE87_RS11805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUE87_RS11845	COG2207	Transcriptional regulator
HUE87_RS11845	COG4753	response regulator
HUE87_RS11850	COG2022	thiamine diphosphate biosynthetic process
HUE87_RS11855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUE87_RS11855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUE87_RS11870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUE87_RS11875	COG0517	IMP dehydrogenase activity
HUE87_RS11875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUE87_RS11880	COG1187	pseudouridine synthase activity
HUE87_RS11885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUE87_RS11890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUE87_RS11895	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUE87_RS11915	COG0300	oxidoreductase activity
HUE87_RS11930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HUE87_RS11945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUE87_RS11965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUE87_RS11965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUE87_RS11985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUE87_RS11995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUE87_RS12000	COG0475	glutathione-regulated potassium exporter activity
HUE87_RS12000	COG0569	domain protein
HUE87_RS12025	COG0577	efflux transmembrane transporter activity
HUE87_RS12025	COG1136	(ABC) transporter
HUE87_RS12075	COG0148	phosphopyruvate hydratase activity
HUE87_RS12080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUE87_RS12085	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUE87_RS12095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUE87_RS12120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUE87_RS12130	COG0746	molybdenum cofactor guanylyltransferase activity
HUE87_RS12135	COG0315	cyclic pyranopterin monophosphate synthase activity
HUE87_RS12150	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUE87_RS12155	COG0571	ribonuclease III activity
HUE87_RS12160	COG0328	RNA-DNA hybrid ribonuclease activity
HUE87_RS12175	COG2855	membrane
HUE87_RS12190	COG1410	methionine synthase
HUE87_RS12190	COG0646	methionine synthase
HUE87_RS12195	COG0606	chelatase, subunit chli
HUE87_RS12200	COG0242	peptide deformylase activity
HUE87_RS12210	COG0740	serine-type endopeptidase activity
HUE87_RS12215	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUE87_RS12220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUE87_RS12225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUE87_RS12230	COG0268	Binds directly to 16S ribosomal RNA
HUE87_RS12235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUE87_RS12240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUE87_RS12245	COG0237	dephospho-CoA kinase activity
HUE87_RS12250	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUE87_RS12305	COG0670	Belongs to the BI1 family
HUE87_RS12310	COG0352	thiamine-phosphate diphosphorylase activity
HUE87_RS12350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUE87_RS12355	COG1121	(ABC) transporter
HUE87_RS12360	COG3443	Belongs to the bacterial solute-binding protein 9 family
HUE87_RS12360	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUE87_RS12365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUE87_RS12370	COG0233	cytoplasmic translational termination
HUE87_RS12375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUE87_RS12380	COG1472	Belongs to the glycosyl hydrolase 3 family
HUE87_RS12390	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUE87_RS12400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUE87_RS12415	COG0676	glucose-6-phosphate 1-epimerase activity
HUE87_RS12425	COG0561	phosphatase activity
HUE87_RS12440	COG0504	CTP synthase activity
HUE87_RS12465	COG1157	protein secretion by the type III secretion system
HUE87_RS12480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUE87_RS12485	COG0107	imidazoleglycerol-phosphate synthase activity
HUE87_RS12495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUE87_RS12505	COG0564	pseudouridine synthase activity
HUE87_RS12510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUE87_RS12515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUE87_RS12530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUE87_RS12535	COG3118	belongs to the thioredoxin family
HUE87_RS12540	COG0372	Belongs to the citrate synthase family
HUE87_RS12545	COG3123	guanosine phosphorylase activity
HUE87_RS12555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group