locus-tag	class	description
D1869_RS00020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1869_RS00180	COG1131	(ABC) transporter
D1869_RS00250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1869_RS00285	COG1280	lysine exporter protein (LysE YggA)
D1869_RS00305	COG0489	protein tyrosine kinase activity
D1869_RS00345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1869_RS00350	COG0730	response to heat
D1869_RS00370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1869_RS00395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1869_RS00400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1869_RS00405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1869_RS00410	COG0189	ligase activity
D1869_RS00425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1869_RS00430	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1869_RS00445	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1869_RS00485	COG0028	Belongs to the TPP enzyme family
D1869_RS00510	COG0017	Asparaginyl-tRNA synthetase
D1869_RS00515	COG0585	pseudouridine synthase activity
D1869_RS00535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_RS00550	COG1648	precorrin-2 dehydrogenase activity
D1869_RS00550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1869_RS00555	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1869_RS00560	COG0113	porphobilinogen synthase activity
D1869_RS00565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1869_RS00570	COG0181	hydroxymethylbilane synthase activity
D1869_RS00595	COG2022	thiamine diphosphate biosynthetic process
D1869_RS00595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1869_RS00605	COG1793	dna ligase
D1869_RS00610	COG0717	Belongs to the dCTP deaminase family
D1869_RS00625	COG2078	PFAM AMMECR1 domain protein
D1869_RS00655	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
D1869_RS00670	COG0504	CTP synthase activity
D1869_RS00675	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D1869_RS00695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1869_RS00705	COG3830	Belongs to the UPF0237 family
D1869_RS00710	COG2848	UPF0210 protein
D1869_RS00765	COG0456	acetyltransferase
D1869_RS00835	COG0051	transcription antitermination factor activity, RNA binding
D1869_RS00840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1869_RS00845	COG0049	tRNA binding
D1869_RS00865	COG1358	cellular component organization or biogenesis
D1869_RS00870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1869_RS00875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1869_RS00880	COG0085	RNA polymerase activity
D1869_RS00890	COG0281	malic enzyme
D1869_RS00895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1869_RS00900	COG0105	UTP biosynthetic process
D1869_RS00915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1869_RS00920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1869_RS00925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1869_RS00935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1869_RS00940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1869_RS00955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1869_RS00970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1869_RS00975	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D1869_RS00985	COG0077	Prephenate dehydratase
D1869_RS00990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1869_RS01010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1869_RS01010	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D1869_RS01025	COG1051	belongs to the nudix hydrolase family
D1869_RS01025	COG1056	cytidyltransferase-related domain
D1869_RS01030	COG1607	acyl-coa hydrolase
D1869_RS01070	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D1869_RS01155	COG1121	(ABC) transporter
D1869_RS01160	COG1980	fructose-bisphosphate aldolase activity
D1869_RS01185	COG0459	protein refolding
D1869_RS01200	COG0124	histidyl-tRNA synthetase
D1869_RS01220	COG0343	queuine tRNA-ribosyltransferase activity
D1869_RS01235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_RS01245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1869_RS01275	COG0477	Major facilitator Superfamily
D1869_RS01285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1869_RS01310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1869_RS01320	COG1047	Peptidyl-prolyl cis-trans
D1869_RS01330	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1869_RS01385	COG4152	abc transporter atp-binding protein
D1869_RS01410	COG1136	(ABC) transporter
D1869_RS01410	COG0577	efflux transmembrane transporter activity
D1869_RS01415	COG1136	(ABC) transporter
D1869_RS01420	COG3383	formate dehydrogenase (NAD+) activity
D1869_RS01445	COG0023	Translation Initiation Factor
D1869_RS01455	COG0010	Belongs to the arginase family
D1869_RS01460	COG0423	glycine-tRNA ligase activity
D1869_RS01490	COG0163	prenyltransferase activity
D1869_RS01500	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
D1869_RS01515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1869_RS01525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1869_RS01530	COG0667	Aldo Keto reductase
D1869_RS01575	COG1110	DNA topoisomerase II activity
D1869_RS01580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_RS01585	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
D1869_RS01630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1869_RS01635	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1869_RS01665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1869_RS01695	COG1201	RNA secondary structure unwinding
D1869_RS01710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1869_RS01715	COG2813	Specifically methylates the guanine in position
D1869_RS01725	COG0438	transferase activity, transferring glycosyl groups
D1869_RS01770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1869_RS01795	COG0200	Binds to the 23S rRNA
D1869_RS01805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1869_RS01825	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1869_RS01830	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1869_RS01855	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1869_RS01870	COG0255	Belongs to the universal ribosomal protein uL29 family
D1869_RS01875	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1869_RS01880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1869_RS01885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1869_RS01890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1869_RS01895	COG0089	rRNA binding
D1869_RS01900	COG0088	Forms part of the polypeptide exit tunnel
D1869_RS01905	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1869_RS01920	COG0473	3-isopropylmalate dehydrogenase activity
D1869_RS01940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1869_RS01945	COG0492	ferredoxin-NADP+ reductase activity
D1869_RS01950	COG0322	excinuclease ABC activity
D1869_RS01980	COG1185	polyribonucleotide nucleotidyltransferase activity
D1869_RS02020	COG0012	GTP binding
D1869_RS02025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D1869_RS02035	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1869_RS02040	COG2264	protein methyltransferase activity
D1869_RS02045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1869_RS02095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1869_RS02155	COG0315	cyclic pyranopterin monophosphate synthase activity
D1869_RS02160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1869_RS02170	COG1881	PFAM PEBP family protein
D1869_RS02175	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1869_RS02180	COG0154	amidase activity
D1869_RS02190	COG1063	alcohol dehydrogenase
D1869_RS02215	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1869_RS02220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1869_RS02230	COG0142	geranyltranstransferase activity
D1869_RS02235	COG0189	ligase activity
D1869_RS02240	COG1522	sequence-specific DNA binding
D1869_RS02270	COG0644	oxidoreductase
D1869_RS02290	COG1053	succinate dehydrogenase
D1869_RS02300	COG2048	Heterodisulfide reductase, subunit B
D1869_RS02310	COG2304	oxidoreductase activity
D1869_RS02315	COG0714	Associated with various cellular activities
D1869_RS02330	COG0303	'Molybdopterin
D1869_RS02335	COG0083	homoserine kinase activity
D1869_RS02340	COG0626	cystathionine gamma-synthase activity
D1869_RS02380	COG0183	Belongs to the thiolase family
D1869_RS02385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1869_RS02445	COG0314	molybdopterin synthase activity
D1869_RS02510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1869_RS02565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_RS02580	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1869_RS02585	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1869_RS02585	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1869_RS02595	COG0071	Belongs to the small heat shock protein (HSP20) family
D1869_RS02620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1869_RS02640	COG1648	precorrin-2 dehydrogenase activity
D1869_RS02640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1869_RS02685	COG0430	RNA-3'-phosphate cyclase activity
D1869_RS02695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1869_RS02700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1869_RS02705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_RS02710	COG1051	belongs to the nudix hydrolase family
D1869_RS02715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1869_RS02715	COG0519	Catalyzes the synthesis of GMP from XMP
D1869_RS02720	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D1869_RS02730	COG1515	deoxyribonuclease V activity
D1869_RS02735	COG1335	isochorismatase
D1869_RS02745	COG0450	alkyl hydroperoxide reductase
D1869_RS02760	COG0372	Belongs to the citrate synthase family
D1869_RS02780	COG4581	dead DEAH box helicase
D1869_RS02790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1869_RS02800	COG0439	Biotin carboxylase
D1869_RS02810	COG1116	anion transmembrane transporter activity
D1869_RS02815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1869_RS02825	COG0805	protein transport
D1869_RS02830	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1869_RS02835	COG0066	3-isopropylmalate dehydratase activity
D1869_RS02840	COG0778	Nitroreductase
D1869_RS02870	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D1869_RS02895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1869_RS02970	COG0495	leucyl-tRNA aminoacylation
D1869_RS02980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1869_RS03000	COG0037	tRNA processing
D1869_RS03010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1869_RS03040	COG0475	glutathione-regulated potassium exporter activity
D1869_RS03045	COG3383	formate dehydrogenase (NAD+) activity
D1869_RS03080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1869_RS03090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1869_RS03095	COG0277	FAD linked oxidase domain protein
D1869_RS03105	COG1252	NADH dehydrogenase
D1869_RS03150	COG0004	ammonium transporteR
D1869_RS03175	COG2814	Major facilitator Superfamily
D1869_RS03190	COG0584	glycerophosphoryl diester phosphodiesterase
D1869_RS03230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1869_RS03260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1869_RS03280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1869_RS03360	COG0574	Belongs to the PEP-utilizing enzyme family
D1869_RS03360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1869_RS03375	COG4608	Belongs to the ABC transporter superfamily
D1869_RS03380	COG0444	Belongs to the ABC transporter superfamily
D1869_RS03385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1869_RS03405	COG2814	Major facilitator Superfamily
D1869_RS03440	COG2002	toxin-antitoxin pair type II binding
D1869_RS03450	COG2814	Major facilitator Superfamily
D1869_RS03495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1869_RS03505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1869_RS03515	COG2368	4-hydroxyphenylacetate
D1869_RS03525	COG0475	glutathione-regulated potassium exporter activity
D1869_RS03530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_RS03535	COG1584	GPR1 FUN34 yaaH family protein
D1869_RS03540	COG4274	PFAM GYD family protein
D1869_RS03555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1869_RS03590	COG2151	metal-sulfur cluster biosynthetic enzyme
D1869_RS03650	COG0028	Belongs to the TPP enzyme family
D1869_RS03655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_RS03680	COG4555	ABC transporter
D1869_RS03750	COG0455	bacterial-type flagellum organization
D1869_RS03760	COG0517	IMP dehydrogenase activity
D1869_RS03775	COG2723	6-phospho-beta-galactosidase activity
D1869_RS03785	COG2226	methyltransferase
D1869_RS03800	COG0515	serine threonine protein kinase
D1869_RS03805	COG0823	Involved in the tonB-independent uptake of proteins
D1869_RS03805	COG1506	peptidase
D1869_RS03805	COG4946	Tricorn protease homolog
D1869_RS03825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_RS03860	COG2814	Major facilitator Superfamily
D1869_RS03870	COG1121	(ABC) transporter
D1869_RS03900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1869_RS03930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D1869_RS03945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D1869_RS03950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D1869_RS03960	COG0459	protein refolding
D1869_RS03965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1869_RS03970	COG0297	glycogen (starch) synthase activity
D1869_RS03980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1869_RS03995	COG0516	GMP reductase activity
D1869_RS03995	COG0517	IMP dehydrogenase activity
D1869_RS04030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1869_RS04035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1869_RS04120	COG1131	(ABC) transporter
D1869_RS04225	COG2124	cytochrome p450
D1869_RS04260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1869_RS04305	COG1201	RNA secondary structure unwinding
D1869_RS04345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1869_RS04360	COG1136	(ABC) transporter
D1869_RS04360	COG0577	efflux transmembrane transporter activity
D1869_RS04370	COG1136	(ABC) transporter
D1869_RS04420	COG2814	Major facilitator Superfamily
D1869_RS04450	COG0693	protein deglycase activity
D1869_RS04455	COG0415	Belongs to the DNA photolyase family
D1869_RS04500	COG0425	Belongs to the sulfur carrier protein TusA family
D1869_RS04560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1869_RS04665	COG0531	amino acid
D1869_RS04745	COG1121	(ABC) transporter
D1869_RS04750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1869_RS04785	COG0501	Belongs to the peptidase M48B family
D1869_RS05035	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1869_RS05055	COG3387	PFAM Glycoside hydrolase 15-related
D1869_RS05060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1869_RS05080	COG2264	protein methyltransferase activity
D1869_RS05140	COG2814	Major facilitator Superfamily
D1869_RS05145	COG1028	Short-chain dehydrogenase reductase Sdr
D1869_RS05160	COG0318	PFAM AMP-dependent synthetase and ligase
D1869_RS05165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1869_RS05205	COG4948	Mandelate Racemase Muconate Lactonizing
D1869_RS05215	COG3842	ATPase activity
D1869_RS05220	COG3833	ABC-type maltose transport systems, permease component
D1869_RS05225	COG1175	transmembrane transport
D1869_RS05285	COG0697	spore germination
D1869_RS05310	COG0393	Putative heavy-metal-binding
D1869_RS05355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1869_RS05390	COG1121	(ABC) transporter
D1869_RS05445	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D1869_RS05460	COG1489	DNA binding
D1869_RS05485	COG0455	bacterial-type flagellum organization
D1869_RS05595	COG1733	regulation of RNA biosynthetic process
D1869_RS05620	COG0298	carbon dioxide binding
D1869_RS05645	COG0298	carbon dioxide binding
D1869_RS05655	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D1869_RS05665	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D1869_RS05690	COG3511	phospholipase C
D1869_RS05700	COG1122	ATPase activity
D1869_RS05735	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D1869_RS05760	COG4133	protoheme IX ABC transporter activity
D1869_RS05800	COG2235	arginine
D1869_RS05810	COG1017	nitric oxide dioxygenase activity
D1869_RS05820	COG2223	nitrite transmembrane transporter activity
D1869_RS05825	COG0243	molybdopterin cofactor binding
D1869_RS05830	COG0243	molybdopterin cofactor binding
D1869_RS05840	COG0831	urea catabolic process
D1869_RS05840	COG0832	Belongs to the urease beta subunit family
D1869_RS05845	COG0804	urea catabolic process
D1869_RS05860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1869_RS05870	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D1869_RS05875	COG1522	sequence-specific DNA binding
D1869_RS05910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1869_RS05920	COG0174	glutamine synthetase
D1869_RS05955	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D1869_RS06005	COG0402	S-adenosylhomocysteine deaminase activity
D1869_RS06040	COG1131	(ABC) transporter
D1869_RS06055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1869_RS06065	COG0383	alpha-mannosidase activity
D1869_RS06070	COG0351	phosphomethylpyrimidine kinase
D1869_RS06070	COG0352	thiamine-phosphate diphosphorylase activity
D1869_RS06070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1869_RS06075	COG0477	Major facilitator Superfamily
D1869_RS06100	COG2017	converts alpha-aldose to the beta-anomer
D1869_RS06145	COG0454	-acetyltransferase
D1869_RS06170	COG1373	ATPase (AAA superfamily
D1869_RS06255	COG1078	dGTPase activity
D1869_RS06260	COG0813	purine-nucleoside phosphorylase activity
D1869_RS06270	COG0438	transferase activity, transferring glycosyl groups
D1869_RS06275	COG3387	PFAM Glycoside hydrolase 15-related
D1869_RS06285	COG1252	NADH dehydrogenase
D1869_RS06360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1869_RS06370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1869_RS06385	COG0045	succinate-CoA ligase (ADP-forming) activity
D1869_RS06430	COG0243	molybdopterin cofactor binding
D1869_RS06460	COG0409	Hydrogenase expression formation protein
D1869_RS06520	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D1869_RS06545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1869_RS06580	COG1185	polyribonucleotide nucleotidyltransferase activity
D1869_RS06610	COG0084	hydrolase, TatD family'
D1869_RS06620	COG2814	Major facilitator Superfamily
D1869_RS06675	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D1869_RS06685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1869_RS06695	COG1960	acyl-CoA dehydrogenase activity
D1869_RS06720	COG2814	Major facilitator Superfamily
D1869_RS06735	COG4946	Tricorn protease homolog
D1869_RS06735	COG0793	Belongs to the peptidase S41A family
D1869_RS06755	COG2271	Major facilitator Superfamily
D1869_RS06820	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D1869_RS06900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_RS06940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1869_RS06945	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1869_RS06950	COG0157	Belongs to the NadC ModD family
D1869_RS06970	COG0719	Fe-S assembly protein
D1869_RS06975	COG0396	ATPase activity
D1869_RS06995	COG0509	glycine decarboxylation via glycine cleavage system
D1869_RS07000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1869_RS07005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1869_RS07010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1869_RS07030	COG0148	phosphopyruvate hydratase activity
D1869_RS07050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_RS07055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1869_RS07070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1869_RS07075	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
D1869_RS07105	COG0525	valine-tRNA ligase activity
D1869_RS07110	COG0436	Aminotransferase
D1869_RS07120	COG0512	Glutamine amidotransferase of anthranilate synthase
D1869_RS07120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1869_RS07125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1869_RS07130	COG0135	phosphoribosylanthranilate isomerase activity
D1869_RS07140	COG0159	tryptophan synthase activity
D1869_RS07145	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
D1869_RS07150	COG1254	Belongs to the acylphosphatase family
D1869_RS07165	COG0574	Belongs to the PEP-utilizing enzyme family
D1869_RS07165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1869_RS07190	COG0527	aspartate kinase activity
D1869_RS07190	COG0460	homoserine dehydrogenase
D1869_RS07200	COG0587	DNA-directed DNA polymerase activity
D1869_RS07210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1869_RS07245	COG0459	protein refolding
D1869_RS07280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1869_RS07295	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1869_RS07300	COG0252	asparaginase activity
D1869_RS07330	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
D1869_RS07380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D1869_RS07380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1869_RS07395	COG0154	amidase activity
D1869_RS07400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1869_RS07405	COG1324	tolerance protein
D1869_RS07440	COG1110	DNA topoisomerase II activity
D1869_RS07450	COG1201	RNA secondary structure unwinding
D1869_RS07480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1869_RS07485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1869_RS07495	COG1028	Short-chain dehydrogenase reductase Sdr
D1869_RS07515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1869_RS07530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1869_RS07565	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D1869_RS07590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1869_RS07595	COG0589	response to stress
D1869_RS07605	COG0126	phosphoglycerate kinase activity
D1869_RS07655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1869_RS07665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1869_RS07675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1869_RS07690	COG0552	protein localization to endoplasmic reticulum
D1869_RS07770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1869_RS07775	COG0006	proline dipeptidase activity
D1869_RS07780	COG0302	gtp cyclohydrolase
D1869_RS07800	COG0318	PFAM AMP-dependent synthetase and ligase
D1869_RS07810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1869_RS07810	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D1869_RS07815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1869_RS07850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1869_RS07875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1869_RS07890	COG1201	RNA secondary structure unwinding
D1869_RS07895	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1869_RS07895	COG0617	tRNA 3'-terminal CCA addition
D1869_RS07895	COG0517	IMP dehydrogenase activity
D1869_RS07920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1869_RS07925	COG1546	Belongs to the CinA family
D1869_RS07925	COG1058	Belongs to the CinA family
D1869_RS07930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1869_RS07945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1869_RS07950	COG0024	Methionine aminopeptidase
D1869_RS07975	COG0561	phosphatase activity
D1869_RS07980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1869_RS08000	COG0417	DNA replication proofreading
D1869_RS08030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1869_RS08050	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
D1869_RS08060	COG1394	ATPase activity, coupled to movement of substances
D1869_RS08075	COG0442	prolyl-tRNA aminoacylation
D1869_RS08085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D1869_RS08090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D1869_RS08105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1869_RS08115	COG0028	Belongs to the TPP enzyme family
D1869_RS08125	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D1869_RS08150	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D1869_RS08160	COG0037	tRNA processing
D1869_RS08170	COG0495	leucyl-tRNA aminoacylation
D1869_RS08180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1869_RS08185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1869_RS08190	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1869_RS08195	COG0131	Imidazoleglycerol-phosphate dehydratase
D1869_RS08200	COG0107	imidazoleglycerol-phosphate synthase activity
D1869_RS08205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1869_RS08210	COG0140	phosphoribosyl-ATP diphosphatase activity
D1869_RS08215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1869_RS08220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1869_RS08225	COG2151	metal-sulfur cluster biosynthetic enzyme
D1869_RS08230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1869_RS08235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1869_RS08245	COG0537	adenosine 5'-monophosphoramidase activity
D1869_RS08255	COG1522	sequence-specific DNA binding
D1869_RS08275	COG0167	dihydroorotate dehydrogenase activity
D1869_RS08280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1869_RS08290	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
D1869_RS08305	COG0284	orotidine-5'-phosphate decarboxylase activity
D1869_RS08345	COG0602	queuosine metabolic process
D1869_RS08350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1869_RS08355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1869_RS08355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1869_RS08360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1869_RS08370	COG0047	phosphoribosylformylglycinamidine synthase activity
D1869_RS08375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1869_RS08380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1869_RS08385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1869_RS08395	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1869_RS08410	COG0137	argininosuccinate synthase activity
D1869_RS08420	COG0505	Belongs to the CarA family
D1869_RS08430	COG0189	ligase activity
D1869_RS08440	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1869_RS08480	COG1024	Enoyl-CoA hydratase
D1869_RS08490	COG0109	protoheme IX farnesyltransferase activity
D1869_RS08490	COG1612	heme a metabolic process
D1869_RS08495	COG0460	homoserine dehydrogenase
D1869_RS08510	COG0312	modulator of DNA gyrase
D1869_RS08520	COG0589	response to stress
D1869_RS08530	COG0009	L-threonylcarbamoyladenylate synthase
D1869_RS08535	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1869_RS08565	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1869_RS08570	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1869_RS08590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1869_RS08635	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1869_RS08640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1869_RS08645	COG0248	Ppx GppA phosphatase
D1869_RS08650	COG2062	phosphohistidine phosphatase, SixA
D1869_RS08665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1869_RS08765	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
D1869_RS08840	COG1131	(ABC) transporter
D1869_RS08875	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1869_RS09015	COG2860	membrane
D1869_RS09045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1869_RS09085	COG2226	methyltransferase
D1869_RS09105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1869_RS09130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1869_RS09190	COG0022	dehydrogenase e1 component
D1869_RS09195	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1869_RS09250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1869_RS09255	COG0601	transmembrane transport
D1869_RS09260	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D1869_RS09270	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1869_RS09285	COG1139	Iron-sulfur cluster binding protein
D1869_RS09345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1869_RS09350	COG2329	Antibiotic biosynthesis monooxygenase
D1869_RS09365	COG2814	Major facilitator Superfamily
D1869_RS09415	COG0417	DNA replication proofreading
D1869_RS09465	COG0477	Major facilitator Superfamily
D1869_RS09545	COG4172	Belongs to the ABC transporter superfamily
D1869_RS09560	COG2814	Major facilitator Superfamily
D1869_RS09565	COG1846	Transcriptional regulator
D1869_RS09570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_RS09690	COG1131	(ABC) transporter
D1869_RS09715	COG0823	Involved in the tonB-independent uptake of proteins
D1869_RS09715	COG1506	peptidase
D1869_RS09715	COG4946	Tricorn protease homolog
D1869_RS09855	COG0531	amino acid
D1869_RS10010	COG1131	(ABC) transporter
D1869_RS10030	COG0644	oxidoreductase
D1869_RS10035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D1869_RS10055	COG2897	thiosulfate sulfurtransferase activity
D1869_RS10060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1869_RS10070	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1869_RS10075	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1869_RS10105	COG1960	acyl-CoA dehydrogenase activity
D1869_RS10110	COG2086	electron transfer activity
D1869_RS10120	COG0644	oxidoreductase
D1869_RS10155	COG1960	acyl-CoA dehydrogenase activity
D1869_RS10160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_RS10170	COG0372	Belongs to the citrate synthase family
D1869_RS10175	COG0517	IMP dehydrogenase activity
D1869_RS10175	COG0516	GMP reductase activity
D1869_RS10180	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D1869_RS10185	COG2079	MmgE PrpD family protein
D1869_RS10190	COG0039	L-malate dehydrogenase activity
D1869_RS10205	COG1968	undecaprenyl-diphosphatase activity
D1869_RS10265	COG1446	asparaginase
D1869_RS10280	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D1869_RS10310	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
D1869_RS10320	COG0437	4 iron, 4 sulfur cluster binding
D1869_RS10325	COG0243	molybdopterin cofactor binding
D1869_RS10355	COG3386	PFAM SMP-30 Gluconolaconase
D1869_RS10440	COG0475	glutathione-regulated potassium exporter activity
D1869_RS10460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1869_RS10465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1869_RS10530	COG0425	Belongs to the sulfur carrier protein TusA family
D1869_RS10535	COG2210	Belongs to the sulfur carrier protein TusA family
D1869_RS10590	COG0095	Lipoate-protein ligase
D1869_RS10615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D1869_RS10625	COG0509	glycine decarboxylation via glycine cleavage system
D1869_RS10630	COG0509	glycine decarboxylation via glycine cleavage system
D1869_RS10635	COG0095	Lipoate-protein ligase
D1869_RS10660	COG1914	H( )-stimulated, divalent metal cation uptake system
D1869_RS10680	COG1702	phosphate starvation-inducible protein PhoH
D1869_RS10685	COG0708	Exodeoxyribonuclease III
D1869_RS10695	COG1444	tRNA N-acetyltransferase activity
D1869_RS10720	COG1175	transmembrane transport
D1869_RS10805	COG1078	dGTPase activity
D1869_RS10815	COG0463	Glycosyl transferase, family 2
D1869_RS10820	COG0275	rRNA processing
D1869_RS10835	COG2192	nodulation
D1869_RS10885	COG0438	transferase activity, transferring glycosyl groups
D1869_RS10945	COG2890	protein-(glutamine-N5) methyltransferase activity
D1869_RS11050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_RS11065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1869_RS11070	COG0114	fumarate hydratase activity
D1869_RS11100	COG0149	triose-phosphate isomerase activity
D1869_RS11120	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D1869_RS11135	COG1321	iron dependent repressor
D1869_RS11155	COG2226	methyltransferase
D1869_RS11170	COG0303	'Molybdopterin
D1869_RS11175	COG0746	molybdenum cofactor guanylyltransferase activity
D1869_RS11240	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1869_RS11245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1869_RS11255	COG1304	FMN binding
D1869_RS11265	COG1355	regulation of microtubule-based process
D1869_RS11270	COG0052	Belongs to the universal ribosomal protein uS2 family
D1869_RS11280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1869_RS11285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1869_RS11290	COG0200	Binds to the 23S rRNA
D1869_RS11300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1869_RS11305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1869_RS11310	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1869_RS11320	COG0432	Pfam Uncharacterised protein family UPF0047
D1869_RS11330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1869_RS11340	COG0417	DNA replication proofreading
D1869_RS11375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1869_RS11410	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D1869_RS11430	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1869_RS11435	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D1869_RS11455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1869_RS11470	COG2267	carboxylic ester hydrolase activity
D1869_RS11480	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1869_RS11485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1869_RS11490	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D1869_RS11490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1869_RS11515	COG0419	ATPase involved in DNA repair
D1869_RS11515	COG0419	ATPase involved in DNA repair
D1869_RS11570	COG0517	IMP dehydrogenase activity
D1869_RS11570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1869_RS11590	COG3118	belongs to the thioredoxin family
D1869_RS11645	COG0492	ferredoxin-NADP+ reductase activity
D1869_RS11655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1869_RS11670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_RS11675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1869_RS11685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1869_RS11700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1869_RS11705	COG0561	phosphatase activity
D1869_RS11730	COG0494	nUDIX hydrolase
D1869_RS11745	COG1618	nucleotide phosphatase activity, acting on free nucleotides
D1869_RS11755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1869_RS11760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1869_RS11760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1869_RS11790	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1869_RS11810	COG0538	isocitrate dehydrogenase activity
D1869_RS11850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1869_RS11855	COG0500	methyltransferase
D1869_RS11855	COG3615	Tellurite resistance protein tehB
D1869_RS11880	COG2096	Adenosyltransferase
D1869_RS11885	COG0697	spore germination
D1869_RS11890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1869_RS11900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1869_RS11905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1869_RS11910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1869_RS12030	COG0069	glutamate synthase activity
D1869_RS12035	COG0067	glutamate synthase
D1869_RS12075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1869_RS12080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1869_RS12115	COG1695	Transcriptional regulator
D1869_RS12140	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D1869_RS12150	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1869_RS12155	COG0649	NAD binding
D1869_RS12160	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1869_RS12165	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1869_RS12175	COG0713	ATP synthesis coupled electron transport
D1869_RS12180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1869_RS12185	COG1007	ATP synthesis coupled electron transport
D1869_RS12190	COG1260	myo-inositol-1-phosphate synthase
D1869_RS12195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1869_RS12195	COG0301	tRNA thio-modification
D1869_RS12245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1869_RS12255	COG0730	response to heat
D1869_RS12265	COG1573	uracil-dna glycosylase
D1869_RS12270	COG1028	Short-chain dehydrogenase reductase Sdr
D1869_RS12275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1869_RS12285	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1869_RS12300	COG0215	cysteine-tRNA ligase activity
D1869_RS12305	COG2222	sugar isomerase
D1869_RS12315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1869_RS12325	COG0433	COG0433 Predicted ATPase
D1869_RS12335	COG1607	acyl-coa hydrolase
D1869_RS12340	COG1063	alcohol dehydrogenase
D1869_RS12355	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D1869_RS12360	COG1960	acyl-CoA dehydrogenase activity
D1869_RS12430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1869_RS12435	COG3959	Transketolase, thiamine diphosphate binding domain
D1869_RS12440	COG3958	Transketolase
D1869_RS12450	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D1869_RS12455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1869_RS12460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1869_RS12465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1869_RS12470	COG0083	homoserine kinase activity
D1869_RS12475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1869_RS12495	COG1199	ATP-dependent helicase activity
D1869_RS12525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1869_RS12530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1869_RS12540	COG1331	Highly conserved protein containing a thioredoxin domain
D1869_RS12560	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D1869_RS12580	COG1192	Involved in chromosome partitioning
D1869_RS12590	COG0277	FAD linked oxidase domain protein
D1869_RS12605	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1869_RS12610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D1869_RS12610	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1869_RS12630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1869_RS12630	COG0617	tRNA 3'-terminal CCA addition
D1869_RS12630	COG0517	IMP dehydrogenase activity
D1869_RS12635	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1869_RS12640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D1869_RS12685	COG1201	RNA secondary structure unwinding
D1869_RS12725	COG0006	proline dipeptidase activity
D1869_RS12745	COG1234	tRNA 3'-trailer cleavage
D1869_RS12750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1869_RS12755	COG0351	phosphomethylpyrimidine kinase
D1869_RS12765	COG1215	transferase activity, transferring glycosyl groups
D1869_RS12785	COG0463	Glycosyl transferase, family 2
D1869_RS12805	COG1063	alcohol dehydrogenase
D1869_RS12810	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D1869_RS12825	COG0519	Catalyzes the synthesis of GMP from XMP
D1869_RS12825	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1869_RS12830	COG0501	Belongs to the peptidase M48B family
D1869_RS12845	COG1830	Aldolase
D1869_RS12860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1869_RS12870	COG0405	Gamma-glutamyltransferase
D1869_RS12885	COG1444	tRNA N-acetyltransferase activity
D1869_RS12910	COG0589	response to stress
D1869_RS12915	COG2271	Major facilitator Superfamily
D1869_RS12935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1869_RS12955	COG0516	GMP reductase activity
D1869_RS12955	COG0517	IMP dehydrogenase activity
D1869_RS12970	COG0730	response to heat
D1869_RS13025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1869_RS13025	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D1869_RS13040	COG0438	transferase activity, transferring glycosyl groups
D1869_RS13050	COG1846	Transcriptional regulator
D1869_RS13120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1869_RS13125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1869_RS13135	COG0402	S-adenosylhomocysteine deaminase activity
D1869_RS13145	COG1573	uracil-dna glycosylase
D1869_RS13170	COG0028	Belongs to the TPP enzyme family
D1869_RS13180	COG0535	radical SAM domain protein
D1869_RS13185	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1869_RS13205	COG1024	Enoyl-CoA hydratase
D1869_RS13210	COG0183	Belongs to the thiolase family
D1869_RS13235	COG2814	Major facilitator Superfamily
D1869_RS13265	COG2271	Major facilitator Superfamily
D1869_RS13295	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1869_RS13300	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1869_RS13300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D1869_RS13320	COG0515	serine threonine protein kinase
D1869_RS13320	COG2815	serine threonine protein kinase
D1869_RS13330	COG2235	arginine
D1869_RS13335	COG0450	alkyl hydroperoxide reductase
D1869_RS13340	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D1869_RS13360	COG1720	tRNA m6t6A37 methyltransferase activity
D1869_RS13370	COG0813	purine-nucleoside phosphorylase activity
D1869_RS13470	COG0530	calcium, potassium:sodium antiporter activity
D1869_RS13475	COG2149	membrane
D1869_RS13480	COG3276	selenocysteine insertion sequence binding
D1869_RS13485	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1869_RS13520	COG0531	amino acid
D1869_RS13525	COG1012	belongs to the aldehyde dehydrogenase family
D1869_RS13530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1869_RS13555	COG1252	NADH dehydrogenase
D1869_RS13565	COG0656	L-ascorbic acid biosynthetic process
D1869_RS13605	COG0586	Pfam SNARE associated Golgi protein
D1869_RS13625	COG1335	isochorismatase
D1869_RS13630	COG1131	(ABC) transporter
D1869_RS13640	COG0412	Dienelactone hydrolase
D1869_RS13685	COG0601	transmembrane transport
D1869_RS13690	COG0444	Belongs to the ABC transporter superfamily
D1869_RS13695	COG4608	Belongs to the ABC transporter superfamily
D1869_RS13720	COG0601	transmembrane transport
D1869_RS13725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1869_RS13730	COG0444	Belongs to the ABC transporter superfamily
D1869_RS13735	COG4608	Belongs to the ABC transporter superfamily
D1869_RS13745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1869_RS13785	COG3386	PFAM SMP-30 Gluconolaconase
D1869_RS13790	COG1028	Short-chain dehydrogenase reductase Sdr
D1869_RS13825	COG1802	Transcriptional regulator
D1869_RS13835	COG1373	ATPase (AAA superfamily
D1869_RS13840	COG4948	Mandelate Racemase Muconate Lactonizing
D1869_RS13845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1869_RS13850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1869_RS13910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1869_RS13995	COG2329	Antibiotic biosynthesis monooxygenase
D1869_RS14005	COG2814	Major facilitator Superfamily
D1869_RS14015	COG0604	alcohol dehydrogenase
D1869_RS14030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1869_RS14090	COG2181	nitrate reductase activity
D1869_RS14100	COG1140	nitrate reductase beta subunit
D1869_RS14105	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D1869_RS14110	COG2223	nitrite transmembrane transporter activity
D1869_RS14160	COG1122	ATPase activity
D1869_RS14190	COG0477	Major facilitator Superfamily
D1869_RS14410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1869_RS14435	COG1770	oligopeptidase
D1869_RS14650	COG1024	Enoyl-CoA hydratase
D1869_RS14655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1869_RS14665	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1869_RS14670	COG1064	alcohol dehydrogenase
D1869_RS14705	COG0318	PFAM AMP-dependent synthetase and ligase
D1869_RS14715	COG1012	belongs to the aldehyde dehydrogenase family
D1869_RS14720	COG2814	Major facilitator Superfamily
D1869_RS14720	COG0477	Major facilitator Superfamily
D1869_RS14740	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1869_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
D1869_RS14750	COG0657	acetylesterase activity
D1869_RS14755	COG1309	transcriptional regulator
D1869_RS14765	COG1063	alcohol dehydrogenase
D1869_RS14770	COG1960	acyl-CoA dehydrogenase activity
D1869_RS14775	COG0318	PFAM AMP-dependent synthetase and ligase
D1869_RS14780	COG0183	Belongs to the thiolase family
D1869_RS14790	COG3383	formate dehydrogenase (NAD+) activity
D1869_RS14800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1869_RS14805	COG1960	acyl-CoA dehydrogenase activity
D1869_RS14810	COG2030	dehydratase
D1869_RS14815	COG1960	acyl-CoA dehydrogenase activity
D1869_RS14840	COG2271	Major facilitator Superfamily
D1869_RS14850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1869_RS14860	COG1024	Enoyl-CoA hydratase
D1869_RS14865	COG0183	Belongs to the thiolase family
D1869_RS14895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1869_RS14895	COG1845	cytochrome c oxidase, subunit III
D1869_RS14925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1869_RS14940	COG0456	acetyltransferase
D1869_RS14945	COG0281	malic enzyme
D1869_RS14955	COG1832	CoA-binding protein
D1869_RS15000	COG0535	radical SAM domain protein
D1869_RS15005	COG0535	radical SAM domain protein
D1869_RS15010	COG0656	L-ascorbic acid biosynthetic process
D1869_RS15050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis