locus-tag	class	description
STK_RS00035	COG1770	oligopeptidase
STK_RS00170	COG1203	CRISPR-associated helicase, Cas3
STK_RS00200	COG2002	toxin-antitoxin pair type II binding
STK_RS00275	COG1024	Enoyl-CoA hydratase
STK_RS00280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_RS00290	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
STK_RS00320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STK_RS00340	COG0318	PFAM AMP-dependent synthetase and ligase
STK_RS00350	COG1012	belongs to the aldehyde dehydrogenase family
STK_RS00355	COG0477	Major facilitator Superfamily
STK_RS00355	COG2814	Major facilitator Superfamily
STK_RS00370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STK_RS00375	COG1250	3-hydroxyacyl-CoA dehydrogenase
STK_RS00380	COG1028	Short-chain dehydrogenase reductase Sdr
STK_RS00385	COG0657	acetylesterase activity
STK_RS00390	COG1309	transcriptional regulator
STK_RS00405	COG1063	alcohol dehydrogenase
STK_RS00410	COG1960	acyl-CoA dehydrogenase activity
STK_RS00415	COG0318	PFAM AMP-dependent synthetase and ligase
STK_RS00420	COG0183	Belongs to the thiolase family
STK_RS00430	COG3383	formate dehydrogenase (NAD+) activity
STK_RS00440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
STK_RS00445	COG1960	acyl-CoA dehydrogenase activity
STK_RS00455	COG1960	acyl-CoA dehydrogenase activity
STK_RS00480	COG2271	Major facilitator Superfamily
STK_RS00490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
STK_RS00500	COG1024	Enoyl-CoA hydratase
STK_RS00505	COG0183	Belongs to the thiolase family
STK_RS00530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
STK_RS00545	COG1845	cytochrome c oxidase, subunit III
STK_RS00545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
STK_RS00575	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
STK_RS00590	COG0456	acetyltransferase
STK_RS00595	COG0281	malic enzyme
STK_RS00605	COG1832	CoA-binding protein
STK_RS00650	COG0535	radical SAM domain protein
STK_RS00655	COG0535	radical SAM domain protein
STK_RS00670	COG0656	L-ascorbic acid biosynthetic process
STK_RS00705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
STK_RS00710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
STK_RS00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
STK_RS00820	COG0174	glutamine synthetase
STK_RS00900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
STK_RS00935	COG1280	lysine exporter protein (LysE YggA)
STK_RS00955	COG0489	protein tyrosine kinase activity
STK_RS00995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
STK_RS01000	COG0730	response to heat
STK_RS01020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
STK_RS01045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
STK_RS01050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STK_RS01055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
STK_RS01060	COG0189	ligase activity
STK_RS01075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
STK_RS01080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
STK_RS01095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
STK_RS01130	COG0028	Belongs to the TPP enzyme family
STK_RS01155	COG0017	Asparaginyl-tRNA synthetase
STK_RS01160	COG0585	pseudouridine synthase activity
STK_RS01175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_RS01190	COG1648	precorrin-2 dehydrogenase activity
STK_RS01190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
STK_RS01195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
STK_RS01200	COG0113	porphobilinogen synthase activity
STK_RS01205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
STK_RS01210	COG0181	hydroxymethylbilane synthase activity
STK_RS01235	COG2022	thiamine diphosphate biosynthetic process
STK_RS01235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
STK_RS01245	COG1793	dna ligase
STK_RS01250	COG0717	Belongs to the dCTP deaminase family
STK_RS01265	COG2078	PFAM AMMECR1 domain protein
STK_RS01295	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
STK_RS01310	COG0504	CTP synthase activity
STK_RS01315	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
STK_RS01335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
STK_RS01350	COG2848	UPF0210 protein
STK_RS01435	COG0456	acetyltransferase
STK_RS01500	COG0051	transcription antitermination factor activity, RNA binding
STK_RS01505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
STK_RS01510	COG0049	tRNA binding
STK_RS01530	COG1358	cellular component organization or biogenesis
STK_RS01535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
STK_RS01540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
STK_RS01545	COG0085	RNA polymerase activity
STK_RS01555	COG0281	malic enzyme
STK_RS01560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
STK_RS01565	COG0105	UTP biosynthetic process
STK_RS01580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
STK_RS01585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STK_RS01590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
STK_RS01600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
STK_RS01605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
STK_RS01620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
STK_RS01635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
STK_RS01640	COG0492	ferredoxin-NADP+ reductase activity
STK_RS01650	COG0077	Prephenate dehydratase
STK_RS01655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
STK_RS01675	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
STK_RS01675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
STK_RS01690	COG1056	cytidyltransferase-related domain
STK_RS01690	COG1051	belongs to the nudix hydrolase family
STK_RS01695	COG1607	acyl-coa hydrolase
STK_RS01730	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
STK_RS01785	COG1121	(ABC) transporter
STK_RS01790	COG1980	fructose-bisphosphate aldolase activity
STK_RS01815	COG0459	protein refolding
STK_RS01830	COG0124	histidyl-tRNA synthetase
STK_RS01865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_RS01875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
STK_RS01920	COG0477	Major facilitator Superfamily
STK_RS01935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
STK_RS01955	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
STK_RS01965	COG1047	Peptidyl-prolyl cis-trans
STK_RS01975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
STK_RS01995	COG3383	formate dehydrogenase (NAD+) activity
STK_RS02015	COG0023	Translation Initiation Factor
STK_RS02030	COG0423	glycine-tRNA ligase activity
STK_RS02060	COG0163	prenyltransferase activity
STK_RS02065	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
STK_RS02080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
STK_RS02090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
STK_RS02095	COG0667	Aldo Keto reductase
STK_RS02140	COG1110	DNA topoisomerase II activity
STK_RS02145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_RS02150	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
STK_RS02195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
STK_RS02200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
STK_RS02210	COG1797	cobyrinic acid a,c-diamide synthase activity
STK_RS02235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
STK_RS02265	COG1201	RNA secondary structure unwinding
STK_RS02280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
STK_RS02285	COG2813	Specifically methylates the guanine in position
STK_RS02295	COG0438	transferase activity, transferring glycosyl groups
STK_RS02335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
STK_RS02360	COG0200	Binds to the 23S rRNA
STK_RS02370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
STK_RS02390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
STK_RS02395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
STK_RS02420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
STK_RS02435	COG0255	Belongs to the universal ribosomal protein uL29 family
STK_RS02440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
STK_RS02445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
STK_RS02450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
STK_RS02455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
STK_RS02460	COG0089	rRNA binding
STK_RS02465	COG0088	Forms part of the polypeptide exit tunnel
STK_RS02470	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
STK_RS02485	COG0473	3-isopropylmalate dehydrogenase activity
STK_RS02505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
STK_RS02510	COG0492	ferredoxin-NADP+ reductase activity
STK_RS02515	COG0322	excinuclease ABC activity
STK_RS02545	COG1185	polyribonucleotide nucleotidyltransferase activity
STK_RS02585	COG0012	GTP binding
STK_RS02590	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
STK_RS02600	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
STK_RS02605	COG2264	protein methyltransferase activity
STK_RS02610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
STK_RS02660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
STK_RS02715	COG0315	cyclic pyranopterin monophosphate synthase activity
STK_RS02720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
STK_RS02725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
STK_RS02730	COG1881	PFAM PEBP family protein
STK_RS02735	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
STK_RS02740	COG0154	amidase activity
STK_RS02750	COG1063	alcohol dehydrogenase
STK_RS02775	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
STK_RS02780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
STK_RS02790	COG0142	geranyltranstransferase activity
STK_RS02795	COG0189	ligase activity
STK_RS02800	COG1522	sequence-specific DNA binding
STK_RS02830	COG0644	oxidoreductase
STK_RS02850	COG1053	succinate dehydrogenase
STK_RS02860	COG2048	Heterodisulfide reductase, subunit B
STK_RS02870	COG2304	oxidoreductase activity
STK_RS02875	COG0714	Associated with various cellular activities
STK_RS02890	COG0303	'Molybdopterin
STK_RS02895	COG0083	homoserine kinase activity
STK_RS02900	COG0626	cystathionine gamma-synthase activity
STK_RS02940	COG0183	Belongs to the thiolase family
STK_RS02945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STK_RS02985	COG1215	transferase activity, transferring glycosyl groups
STK_RS03000	COG0351	phosphomethylpyrimidine kinase
STK_RS03005	COG0314	molybdopterin synthase activity
STK_RS03065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STK_RS03095	COG0720	synthase
STK_RS03120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_RS03135	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
STK_RS03140	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STK_RS03140	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STK_RS03150	COG0071	Belongs to the small heat shock protein (HSP20) family
STK_RS03175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
STK_RS03195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
STK_RS03195	COG1648	precorrin-2 dehydrogenase activity
STK_RS03240	COG0430	RNA-3'-phosphate cyclase activity
STK_RS03250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
STK_RS03255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STK_RS03260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_RS03265	COG1051	belongs to the nudix hydrolase family
STK_RS03270	COG0519	Catalyzes the synthesis of GMP from XMP
STK_RS03270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
STK_RS03275	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
STK_RS03285	COG1515	deoxyribonuclease V activity
STK_RS03290	COG1335	isochorismatase
STK_RS03300	COG0450	alkyl hydroperoxide reductase
STK_RS03315	COG0372	Belongs to the citrate synthase family
STK_RS03335	COG4581	dead DEAH box helicase
STK_RS03345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
STK_RS03355	COG0439	Biotin carboxylase
STK_RS03365	COG1116	anion transmembrane transporter activity
STK_RS03365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
STK_RS03370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STK_RS03380	COG0805	protein transport
STK_RS03385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
STK_RS03390	COG0066	3-isopropylmalate dehydratase activity
STK_RS03395	COG0778	Nitroreductase
STK_RS03425	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
STK_RS03450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
STK_RS03525	COG0495	leucyl-tRNA aminoacylation
STK_RS03535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STK_RS03555	COG0037	tRNA processing
STK_RS03565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
STK_RS03595	COG0475	glutathione-regulated potassium exporter activity
STK_RS03600	COG0243	molybdopterin cofactor binding
STK_RS03640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
STK_RS03650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
STK_RS03655	COG0277	FAD linked oxidase domain protein
STK_RS03665	COG1252	NADH dehydrogenase
STK_RS03710	COG0004	ammonium transporteR
STK_RS03735	COG2814	Major facilitator Superfamily
STK_RS03745	COG0584	glycerophosphoryl diester phosphodiesterase
STK_RS03780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
STK_RS03825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
STK_RS03845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STK_RS03915	COG0574	Belongs to the PEP-utilizing enzyme family
STK_RS03915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STK_RS03930	COG4608	Belongs to the ABC transporter superfamily
STK_RS03935	COG0444	Belongs to the ABC transporter superfamily
STK_RS03940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STK_RS03960	COG2814	Major facilitator Superfamily
STK_RS04035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
STK_RS04045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
STK_RS04055	COG2368	4-hydroxyphenylacetate
STK_RS04065	COG0475	glutathione-regulated potassium exporter activity
STK_RS04070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_RS04090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
STK_RS04125	COG2151	metal-sulfur cluster biosynthetic enzyme
STK_RS04180	COG0028	Belongs to the TPP enzyme family
STK_RS04200	COG4555	ABC transporter
STK_RS04280	COG0455	bacterial-type flagellum organization
STK_RS04285	COG0517	IMP dehydrogenase activity
STK_RS04290	COG3384	dioxygenase
STK_RS04300	COG2723	6-phospho-beta-galactosidase activity
STK_RS04325	COG0515	serine threonine protein kinase
STK_RS04330	COG4946	Tricorn protease homolog
STK_RS04330	COG1506	peptidase
STK_RS04330	COG0823	Involved in the tonB-independent uptake of proteins
STK_RS04355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_RS04395	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
STK_RS04500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
STK_RS04505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
STK_RS04540	COG0516	GMP reductase activity
STK_RS04540	COG0517	IMP dehydrogenase activity
STK_RS04555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
STK_RS04565	COG0297	glycogen (starch) synthase activity
STK_RS04570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
STK_RS04585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
STK_RS04590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
STK_RS04605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
STK_RS04635	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
STK_RS04650	COG0501	Belongs to the peptidase M48B family
STK_RS04685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STK_RS04690	COG1121	(ABC) transporter
STK_RS04745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
STK_RS04755	COG0531	amino acid
STK_RS04765	COG3547	Transposase (IS116 IS110 IS902 family)
STK_RS04840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STK_RS04845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STK_RS04880	COG0425	Belongs to the sulfur carrier protein TusA family
STK_RS04890	COG0425	Belongs to the sulfur carrier protein TusA family
STK_RS04935	COG0415	Belongs to the DNA photolyase family
STK_RS04940	COG0693	protein deglycase activity
STK_RS05000	COG1136	(ABC) transporter
STK_RS05010	COG0577	efflux transmembrane transporter activity
STK_RS05010	COG1136	(ABC) transporter
STK_RS05045	COG2814	Major facilitator Superfamily
STK_RS05070	COG1960	acyl-CoA dehydrogenase activity
STK_RS05080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
STK_RS05090	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
STK_RS05145	COG2814	Major facilitator Superfamily
STK_RS05155	COG0084	hydrolase, TatD family'
STK_RS05160	COG0300	oxidoreductase activity
STK_RS05185	COG1185	polyribonucleotide nucleotidyltransferase activity
STK_RS05220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
STK_RS05245	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
STK_RS05335	COG0045	succinate-CoA ligase (ADP-forming) activity
STK_RS05350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
STK_RS05360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
STK_RS05385	COG1252	NADH dehydrogenase
STK_RS05395	COG3387	PFAM Glycoside hydrolase 15-related
STK_RS05400	COG0438	transferase activity, transferring glycosyl groups
STK_RS05410	COG0813	purine-nucleoside phosphorylase activity
STK_RS05415	COG1078	dGTPase activity
STK_RS05485	COG1373	ATPase (AAA superfamily
STK_RS05515	COG0454	-acetyltransferase
STK_RS05590	COG0477	Major facilitator Superfamily
STK_RS05595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
STK_RS05595	COG0352	thiamine-phosphate diphosphorylase activity
STK_RS05595	COG0351	phosphomethylpyrimidine kinase
STK_RS05600	COG0383	alpha-mannosidase activity
STK_RS05610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
STK_RS05630	COG2080	2 iron, 2 sulfur cluster binding
STK_RS05630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
STK_RS05635	COG0402	S-adenosylhomocysteine deaminase activity
STK_RS05680	COG1522	sequence-specific DNA binding
STK_RS05685	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
STK_RS05695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
STK_RS05710	COG0804	urea catabolic process
STK_RS05725	COG2235	arginine
STK_RS05755	COG4133	protoheme IX ABC transporter activity
STK_RS05780	COG0433	COG0433 Predicted ATPase
STK_RS05815	COG0455	bacterial-type flagellum organization
STK_RS05850	COG1489	DNA binding
STK_RS05870	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
STK_RS05905	COG1121	(ABC) transporter
STK_RS05945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STK_RS05990	COG0393	Putative heavy-metal-binding
STK_RS06025	COG0697	spore germination
STK_RS06060	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
STK_RS06080	COG1132	(ABC) transporter
STK_RS06115	COG1175	transmembrane transport
STK_RS06120	COG3833	ABC-type maltose transport systems, permease component
STK_RS06125	COG3842	ATPase activity
STK_RS06135	COG4948	Mandelate Racemase Muconate Lactonizing
STK_RS06140	COG1028	Short-chain dehydrogenase reductase Sdr
STK_RS06155	COG0318	PFAM AMP-dependent synthetase and ligase
STK_RS06160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STK_RS06175	COG1012	belongs to the aldehyde dehydrogenase family
STK_RS06190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
STK_RS06195	COG0167	dihydroorotate dehydrogenase activity
STK_RS06195	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
STK_RS06220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
STK_RS06225	COG3387	PFAM Glycoside hydrolase 15-related
STK_RS06295	COG1122	ATPase activity
STK_RS06360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
STK_RS06375	COG2124	cytochrome p450
STK_RS06390	COG1401	restriction endodeoxyribonuclease activity
STK_RS06400	COG1401	restriction endodeoxyribonuclease activity
STK_RS06445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
STK_RS06460	COG4946	Tricorn protease homolog
STK_RS06460	COG0793	Belongs to the peptidase S41A family
STK_RS06470	COG2271	Major facilitator Superfamily
STK_RS06570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_RS06610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
STK_RS06615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
STK_RS06620	COG0157	Belongs to the NadC ModD family
STK_RS06635	COG0719	Fe-S assembly protein
STK_RS06640	COG0396	ATPase activity
STK_RS06660	COG0509	glycine decarboxylation via glycine cleavage system
STK_RS06665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
STK_RS06670	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STK_RS06675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STK_RS06695	COG0148	phosphopyruvate hydratase activity
STK_RS06715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_RS06720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
STK_RS06735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
STK_RS06740	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
STK_RS06775	COG0525	valine-tRNA ligase activity
STK_RS06780	COG0436	Aminotransferase
STK_RS06790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
STK_RS06790	COG0512	Glutamine amidotransferase of anthranilate synthase
STK_RS06795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
STK_RS06800	COG0135	phosphoribosylanthranilate isomerase activity
STK_RS06810	COG0159	tryptophan synthase activity
STK_RS06815	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
STK_RS06820	COG1254	Belongs to the acylphosphatase family
STK_RS06835	COG0574	Belongs to the PEP-utilizing enzyme family
STK_RS06835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STK_RS06860	COG0527	aspartate kinase activity
STK_RS06860	COG0460	homoserine dehydrogenase
STK_RS06870	COG0587	DNA-directed DNA polymerase activity
STK_RS06880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
STK_RS06915	COG0459	protein refolding
STK_RS06950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
STK_RS06965	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STK_RS06970	COG0252	asparaginase activity
STK_RS07000	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
STK_RS07050	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
STK_RS07050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
STK_RS07065	COG0154	amidase activity
STK_RS07070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STK_RS07075	COG1324	tolerance protein
STK_RS07110	COG1110	DNA topoisomerase II activity
STK_RS07120	COG1201	RNA secondary structure unwinding
STK_RS07150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
STK_RS07155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
STK_RS07165	COG1028	Short-chain dehydrogenase reductase Sdr
STK_RS07185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STK_RS07200	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
STK_RS07560	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
STK_RS07585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
STK_RS07590	COG0589	response to stress
STK_RS07600	COG0126	phosphoglycerate kinase activity
STK_RS07650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
STK_RS07660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
STK_RS07670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
STK_RS07685	COG0552	protein localization to endoplasmic reticulum
STK_RS07750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
STK_RS07765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
STK_RS07770	COG0006	proline dipeptidase activity
STK_RS07775	COG0302	gtp cyclohydrolase
STK_RS07795	COG0318	PFAM AMP-dependent synthetase and ligase
STK_RS07805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
STK_RS07805	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
STK_RS07810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
STK_RS07840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STK_RS07865	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
STK_RS07880	COG1201	RNA secondary structure unwinding
STK_RS07885	COG0617	tRNA 3'-terminal CCA addition
STK_RS07885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
STK_RS07885	COG0517	IMP dehydrogenase activity
STK_RS07910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
STK_RS07915	COG1058	Belongs to the CinA family
STK_RS07915	COG1546	Belongs to the CinA family
STK_RS07920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
STK_RS07935	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
STK_RS07940	COG0024	Methionine aminopeptidase
STK_RS07965	COG0561	phosphatase activity
STK_RS07970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
STK_RS07990	COG0417	DNA replication proofreading
STK_RS08020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STK_RS08040	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
STK_RS08050	COG1394	ATPase activity, coupled to movement of substances
STK_RS08065	COG0442	prolyl-tRNA aminoacylation
STK_RS08075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
STK_RS08080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
STK_RS08095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
STK_RS08105	COG0028	Belongs to the TPP enzyme family
STK_RS08115	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
STK_RS08125	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
STK_RS08140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
STK_RS08150	COG0037	tRNA processing
STK_RS08160	COG0495	leucyl-tRNA aminoacylation
STK_RS08170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
STK_RS08175	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
STK_RS08180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
STK_RS08185	COG0131	Imidazoleglycerol-phosphate dehydratase
STK_RS08190	COG0107	imidazoleglycerol-phosphate synthase activity
STK_RS08195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
STK_RS08200	COG0140	phosphoribosyl-ATP diphosphatase activity
STK_RS08205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
STK_RS08210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
STK_RS08215	COG2151	metal-sulfur cluster biosynthetic enzyme
STK_RS08220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
STK_RS08225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STK_RS08235	COG0537	adenosine 5'-monophosphoramidase activity
STK_RS08245	COG1522	sequence-specific DNA binding
STK_RS08265	COG0167	dihydroorotate dehydrogenase activity
STK_RS08270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
STK_RS08280	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
STK_RS08285	COG0540	Belongs to the ATCase OTCase family
STK_RS08295	COG0284	orotidine-5'-phosphate decarboxylase activity
STK_RS08335	COG0602	queuosine metabolic process
STK_RS08340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
STK_RS08345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STK_RS08345	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STK_RS08350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
STK_RS08360	COG0047	phosphoribosylformylglycinamidine synthase activity
STK_RS08365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
STK_RS08370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
STK_RS08375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
STK_RS08380	COG0151	Belongs to the GarS family
STK_RS08385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
STK_RS08400	COG0137	argininosuccinate synthase activity
STK_RS08410	COG0505	Belongs to the CarA family
STK_RS08420	COG0189	ligase activity
STK_RS08430	COG1250	3-hydroxyacyl-CoA dehydrogenase
STK_RS08470	COG1024	Enoyl-CoA hydratase
STK_RS08480	COG0109	protoheme IX farnesyltransferase activity
STK_RS08480	COG1612	heme a metabolic process
STK_RS08485	COG0460	homoserine dehydrogenase
STK_RS08500	COG0312	modulator of DNA gyrase
STK_RS08510	COG0589	response to stress
STK_RS08520	COG0009	L-threonylcarbamoyladenylate synthase
STK_RS08525	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STK_RS08555	COG0674	pyruvate-flavodoxin oxidoreductase activity
STK_RS08560	COG1013	pyruvate-flavodoxin oxidoreductase activity
STK_RS08575	COG2002	toxin-antitoxin pair type II binding
STK_RS08585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
STK_RS08620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
STK_RS08625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
STK_RS08630	COG0248	Ppx GppA phosphatase
STK_RS08635	COG2062	phosphohistidine phosphatase, SixA
STK_RS08755	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
STK_RS08765	COG2308	Evidence 4 Homologs of previously reported genes of
STK_RS08770	COG1305	Transglutaminase-like
STK_RS08815	COG1131	(ABC) transporter
STK_RS08835	COG1131	(ABC) transporter
STK_RS08850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STK_RS08990	COG2860	membrane
STK_RS09020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
STK_RS09060	COG2226	methyltransferase
STK_RS09080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
STK_RS09110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STK_RS09215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STK_RS09220	COG0601	transmembrane transport
STK_RS09225	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
STK_RS09235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
STK_RS09250	COG1139	Iron-sulfur cluster binding protein
STK_RS09315	COG2329	Antibiotic biosynthesis monooxygenase
STK_RS09330	COG2814	Major facilitator Superfamily
STK_RS09370	COG2409	Drug exporters of the RND superfamily
STK_RS09370	COG1033	growth of symbiont in host cell
STK_RS09380	COG0417	DNA replication proofreading
STK_RS09515	COG1063	alcohol dehydrogenase
STK_RS09520	COG0179	Fumarylacetoacetate (FAA) hydrolase
STK_RS09525	COG4172	Belongs to the ABC transporter superfamily
STK_RS09540	COG2814	Major facilitator Superfamily
STK_RS09545	COG1846	Transcriptional regulator
STK_RS09550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_RS09570	COG2217	Heavy metal translocating P-type atpase
STK_RS09670	COG1131	(ABC) transporter
STK_RS09690	COG1131	(ABC) transporter
STK_RS09840	COG0531	amino acid
STK_RS09920	COG1131	(ABC) transporter
STK_RS09940	COG0644	oxidoreductase
STK_RS09945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
STK_RS09980	COG2897	thiosulfate sulfurtransferase activity
STK_RS09985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
STK_RS09995	COG1013	pyruvate-flavodoxin oxidoreductase activity
STK_RS10000	COG0674	pyruvate-flavodoxin oxidoreductase activity
STK_RS10005	COG1144	Oxidoreductase
STK_RS10030	COG1960	acyl-CoA dehydrogenase activity
STK_RS10035	COG2086	electron transfer activity
STK_RS10045	COG0644	oxidoreductase
STK_RS10070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STK_RS10090	COG1960	acyl-CoA dehydrogenase activity
STK_RS10095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_RS10105	COG0372	Belongs to the citrate synthase family
STK_RS10110	COG0517	IMP dehydrogenase activity
STK_RS10110	COG0516	GMP reductase activity
STK_RS10115	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
STK_RS10120	COG2079	MmgE PrpD family protein
STK_RS10125	COG0039	L-malate dehydrogenase activity
STK_RS10135	COG1968	undecaprenyl-diphosphatase activity
STK_RS10190	COG1446	asparaginase
STK_RS10205	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
STK_RS10235	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
STK_RS10245	COG0437	4 iron, 4 sulfur cluster binding
STK_RS10250	COG0243	molybdopterin cofactor binding
STK_RS10280	COG3386	PFAM SMP-30 Gluconolaconase
STK_RS10360	COG0475	glutathione-regulated potassium exporter activity
STK_RS10375	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
STK_RS10380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STK_RS10435	COG0425	Belongs to the sulfur carrier protein TusA family
STK_RS10440	COG2210	Belongs to the sulfur carrier protein TusA family
STK_RS10495	COG0095	Lipoate-protein ligase
STK_RS10530	COG0509	glycine decarboxylation via glycine cleavage system
STK_RS10535	COG0509	glycine decarboxylation via glycine cleavage system
STK_RS10540	COG0095	Lipoate-protein ligase
STK_RS10565	COG1914	H( )-stimulated, divalent metal cation uptake system
STK_RS10605	COG1702	phosphate starvation-inducible protein PhoH
STK_RS10610	COG0708	Exodeoxyribonuclease III
STK_RS10620	COG1444	tRNA N-acetyltransferase activity
STK_RS10655	COG1175	transmembrane transport
STK_RS10660	COG1373	ATPase (AAA superfamily
STK_RS10680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
STK_RS10775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
STK_RS10855	COG2192	nodulation
STK_RS10865	COG2192	nodulation
STK_RS10890	COG0438	transferase activity, transferring glycosyl groups
STK_RS10905	COG1215	transferase activity, transferring glycosyl groups
STK_RS10920	COG2264	protein methyltransferase activity
STK_RS10925	COG0463	Glycosyl transferase, family 2
STK_RS10925	COG1216	Glycosyl transferase, family 2
STK_RS10995	COG1078	dGTPase activity
STK_RS11065	COG0515	serine threonine protein kinase
STK_RS11065	COG2815	serine threonine protein kinase
STK_RS11145	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
STK_RS11205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_RS11220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STK_RS11225	COG0114	fumarate hydratase activity
STK_RS11255	COG0149	triose-phosphate isomerase activity
STK_RS11280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
STK_RS11295	COG1321	iron dependent repressor
STK_RS11315	COG2226	methyltransferase
STK_RS11330	COG0303	'Molybdopterin
STK_RS11335	COG0746	molybdenum cofactor guanylyltransferase activity
STK_RS11395	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
STK_RS11400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STK_RS11410	COG1304	FMN binding
STK_RS11420	COG1355	regulation of microtubule-based process
STK_RS11425	COG0052	Belongs to the universal ribosomal protein uS2 family
STK_RS11435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
STK_RS11440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
STK_RS11445	COG0200	Binds to the 23S rRNA
STK_RS11455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
STK_RS11460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
STK_RS11465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
STK_RS11475	COG0432	Pfam Uncharacterised protein family UPF0047
STK_RS11485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
STK_RS11495	COG0417	DNA replication proofreading
STK_RS11530	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
STK_RS11580	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
STK_RS11600	COG1250	3-hydroxyacyl-CoA dehydrogenase
STK_RS11605	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STK_RS11620	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
STK_RS11635	COG2267	carboxylic ester hydrolase activity
STK_RS11645	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
STK_RS11650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
STK_RS11655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
STK_RS11655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
STK_RS11680	COG0419	ATPase involved in DNA repair
STK_RS11680	COG0419	ATPase involved in DNA repair
STK_RS11735	COG0517	IMP dehydrogenase activity
STK_RS11735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
STK_RS11755	COG3118	belongs to the thioredoxin family
STK_RS11805	COG0492	ferredoxin-NADP+ reductase activity
STK_RS11815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
STK_RS11830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_RS11835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
STK_RS11845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
STK_RS11860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
STK_RS11865	COG0561	phosphatase activity
STK_RS11890	COG0494	nUDIX hydrolase
STK_RS11905	COG1618	nucleotide phosphatase activity, acting on free nucleotides
STK_RS11915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
STK_RS11920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
STK_RS11920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
STK_RS11950	COG2154	pterin-4-alpha-carbinolamine dehydratase
STK_RS11970	COG0538	isocitrate dehydrogenase activity
STK_RS12010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
STK_RS12040	COG2096	Adenosyltransferase
STK_RS12060	COG0697	spore germination
STK_RS12065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
STK_RS12075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
STK_RS12080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
STK_RS12085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
STK_RS12150	COG0069	glutamate synthase activity
STK_RS12155	COG0067	glutamate synthase
STK_RS12175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STK_RS12180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
STK_RS12215	COG1695	Transcriptional regulator
STK_RS12240	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
STK_RS12250	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STK_RS12255	COG0649	NAD binding
STK_RS12260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
STK_RS12265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STK_RS12275	COG0713	ATP synthesis coupled electron transport
STK_RS12280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
STK_RS12285	COG1007	ATP synthesis coupled electron transport
STK_RS12290	COG1260	myo-inositol-1-phosphate synthase
STK_RS12295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
STK_RS12295	COG0301	tRNA thio-modification
STK_RS12355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
STK_RS12365	COG0730	response to heat
STK_RS12375	COG1573	uracil-dna glycosylase
STK_RS12380	COG1028	Short-chain dehydrogenase reductase Sdr
STK_RS12395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
STK_RS12410	COG0215	cysteine-tRNA ligase activity
STK_RS12415	COG2222	sugar isomerase
STK_RS12435	COG0433	COG0433 Predicted ATPase
STK_RS12445	COG1607	acyl-coa hydrolase
STK_RS12450	COG1063	alcohol dehydrogenase
STK_RS12470	COG1960	acyl-CoA dehydrogenase activity
STK_RS12545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
STK_RS12550	COG3959	Transketolase, thiamine diphosphate binding domain
STK_RS12555	COG3958	Transketolase
STK_RS12565	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
STK_RS12570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
STK_RS12575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
STK_RS12580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
STK_RS12585	COG0083	homoserine kinase activity
STK_RS12590	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
STK_RS12610	COG1199	ATP-dependent helicase activity
STK_RS12630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
STK_RS12635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
STK_RS12645	COG1331	Highly conserved protein containing a thioredoxin domain
STK_RS12665	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
STK_RS12685	COG1192	Involved in chromosome partitioning
STK_RS12695	COG0277	FAD linked oxidase domain protein
STK_RS12710	COG1013	pyruvate-flavodoxin oxidoreductase activity
STK_RS12715	COG0674	pyruvate-flavodoxin oxidoreductase activity
STK_RS12715	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
STK_RS12735	COG0617	tRNA 3'-terminal CCA addition
STK_RS12735	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
STK_RS12735	COG0517	IMP dehydrogenase activity
STK_RS12740	COG0123	including yeast histone deacetylase and acetoin utilization protein
STK_RS12745	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
STK_RS12790	COG0513	Belongs to the DEAD box helicase family
STK_RS12830	COG0006	proline dipeptidase activity
STK_RS12850	COG1234	tRNA 3'-trailer cleavage
STK_RS12855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STK_RS12860	COG0351	phosphomethylpyrimidine kinase
STK_RS12860	COG0352	thiamine-phosphate diphosphorylase activity
STK_RS12870	COG1215	transferase activity, transferring glycosyl groups
STK_RS12890	COG0463	Glycosyl transferase, family 2
STK_RS12910	COG1063	alcohol dehydrogenase
STK_RS12915	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
STK_RS12930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
STK_RS12930	COG0519	Catalyzes the synthesis of GMP from XMP
STK_RS12935	COG0501	Belongs to the peptidase M48B family
STK_RS12955	COG1830	Aldolase
STK_RS12970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
STK_RS12980	COG0405	Gamma-glutamyltransferase
STK_RS12995	COG1444	tRNA N-acetyltransferase activity
STK_RS13020	COG0589	response to stress
STK_RS13025	COG2271	Major facilitator Superfamily
STK_RS13045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
STK_RS13065	COG0516	GMP reductase activity
STK_RS13065	COG0517	IMP dehydrogenase activity
STK_RS13080	COG0730	response to heat
STK_RS13125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
STK_RS13125	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
STK_RS13140	COG0438	transferase activity, transferring glycosyl groups
STK_RS13150	COG1846	Transcriptional regulator
STK_RS13220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STK_RS13225	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
STK_RS13235	COG0402	S-adenosylhomocysteine deaminase activity
STK_RS13245	COG1573	uracil-dna glycosylase
STK_RS13270	COG0028	Belongs to the TPP enzyme family
STK_RS13280	COG0535	radical SAM domain protein
STK_RS13285	COG1250	3-hydroxyacyl-CoA dehydrogenase
STK_RS13305	COG1024	Enoyl-CoA hydratase
STK_RS13310	COG0183	Belongs to the thiolase family
STK_RS13320	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STK_RS13335	COG2814	Major facilitator Superfamily
STK_RS13365	COG2271	Major facilitator Superfamily
STK_RS13395	COG1013	pyruvate-flavodoxin oxidoreductase activity
STK_RS13400	COG0674	pyruvate-flavodoxin oxidoreductase activity
STK_RS13400	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
STK_RS13420	COG2815	serine threonine protein kinase
STK_RS13420	COG0515	serine threonine protein kinase
STK_RS13430	COG2235	arginine
STK_RS13435	COG0450	alkyl hydroperoxide reductase
STK_RS13440	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
STK_RS13460	COG1720	tRNA m6t6A37 methyltransferase activity
STK_RS13470	COG0813	purine-nucleoside phosphorylase activity
STK_RS13495	COG2271	Major facilitator Superfamily
STK_RS13550	COG2271	Major facilitator Superfamily
STK_RS13565	COG2149	membrane
STK_RS13590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
STK_RS13620	COG0531	amino acid
STK_RS13625	COG1012	belongs to the aldehyde dehydrogenase family
STK_RS13630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STK_RS13655	COG1252	NADH dehydrogenase
STK_RS13670	COG0656	L-ascorbic acid biosynthetic process
STK_RS13700	COG0586	Pfam SNARE associated Golgi protein
STK_RS13780	COG1335	isochorismatase
STK_RS13785	COG1131	(ABC) transporter
STK_RS13795	COG0412	Dienelactone hydrolase
STK_RS13860	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
STK_RS13905	COG0601	transmembrane transport
STK_RS13910	COG0444	Belongs to the ABC transporter superfamily
STK_RS13915	COG4608	Belongs to the ABC transporter superfamily
STK_RS13930	COG0601	transmembrane transport
STK_RS13935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STK_RS13940	COG0444	Belongs to the ABC transporter superfamily
STK_RS13945	COG4608	Belongs to the ABC transporter superfamily
STK_RS13955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
STK_RS13975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STK_RS14005	COG3386	PFAM SMP-30 Gluconolaconase
STK_RS14010	COG1028	Short-chain dehydrogenase reductase Sdr
STK_RS14015	COG2814	Major facilitator Superfamily
STK_RS14020	COG2721	sulfolactate sulfo-lyase activity
STK_RS14025	COG2721	sulfolactate sulfo-lyase activity
STK_RS14035	COG1802	Transcriptional regulator
STK_RS14050	COG2897	thiosulfate sulfurtransferase activity
STK_RS14060	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
STK_RS14070	COG2046	Belongs to the sulfate adenylyltransferase family
STK_RS14085	COG1373	ATPase (AAA superfamily
STK_RS14090	COG4948	Mandelate Racemase Muconate Lactonizing
STK_RS14095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STK_RS14100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
STK_RS14105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
STK_RS14175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STK_RS14260	COG2329	Antibiotic biosynthesis monooxygenase
STK_RS14280	COG0604	alcohol dehydrogenase
STK_RS14295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STK_RS14350	COG0477	Major facilitator Superfamily
STK_RS14615	COG1215	transferase activity, transferring glycosyl groups
STK_RS14975	COG0275	rRNA processing