locus-tag	class	description
EP379_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EP379_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EP379_RS00020	COG0187	DNA topoisomerase II activity
EP379_RS00025	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EP379_RS00035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EP379_RS00045	COG0751	glycine-tRNA ligase activity
EP379_RS00055	COG0482	sulfurtransferase activity
EP379_RS00070	COG0174	glutamine synthetase
EP379_RS00080	COG3852	Histidine kinase
EP379_RS00085	COG2204	response regulator
EP379_RS00135	COG1872	DUF167
EP379_RS00160	COG0708	Exodeoxyribonuclease III
EP379_RS00185	COG1309	transcriptional regulator
EP379_RS00190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EP379_RS00205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EP379_RS00210	COG2003	Belongs to the UPF0758 family
EP379_RS00215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EP379_RS00230	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EP379_RS00245	COG1131	(ABC) transporter
EP379_RS00265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EP379_RS00270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EP379_RS00285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP379_RS00285	COG0425	Belongs to the sulfur carrier protein TusA family
EP379_RS00300	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EP379_RS00320	COG1136	(ABC) transporter
EP379_RS00345	COG2861	carbohydrate metabolic process
EP379_RS00350	COG0793	Belongs to the peptidase S41A family
EP379_RS00355	COG4942	peptidase
EP379_RS00360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EP379_RS00365	COG0640	Transcriptional regulator
EP379_RS00375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP379_RS00380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP379_RS00390	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EP379_RS00395	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EP379_RS00400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EP379_RS00405	COG0167	dihydroorotate dehydrogenase activity
EP379_RS00435	COG3409	Peptidoglycan-binding domain 1 protein
EP379_RS00435	COG3267	Type II secretory pathway component ExeA
EP379_RS00445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP379_RS00450	COG1459	type II secretion system
EP379_RS00550	COG0543	2 iron, 2 sulfur cluster binding
EP379_RS00560	COG0540	Belongs to the ATCase OTCase family
EP379_RS00565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EP379_RS00570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EP379_RS00575	COG1678	Uncharacterized ACR, COG1678
EP379_RS00580	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EP379_RS00600	COG2205	protein histidine kinase activity
EP379_RS00600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP379_RS00600	COG2198	Histidine kinase
EP379_RS00600	COG0784	Response regulator, receiver
EP379_RS00610	COG0210	DNA helicase
EP379_RS00615	COG0606	chelatase, subunit chli
EP379_RS00630	COG0347	Belongs to the P(II) protein family
EP379_RS00635	COG0004	ammonium transporteR
EP379_RS00645	COG1125	glycine betaine transport
EP379_RS00645	COG0517	IMP dehydrogenase activity
EP379_RS00650	COG0390	transport system, permease component
EP379_RS00660	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EP379_RS00665	COG1166	arginine decarboxylase activity
EP379_RS00685	COG0018	arginyl-trna synthetase
EP379_RS00690	COG3549	Plasmid maintenance system killer
EP379_RS00705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EP379_RS00725	COG3001	Fructosamine kinase
EP379_RS00730	COG1560	Kdo2-lipid A biosynthetic process
EP379_RS00735	COG0037	tRNA processing
EP379_RS00745	COG0330	HflC and HflK could
EP379_RS00755	COG2076	Multidrug Resistance protein
EP379_RS00760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EP379_RS00785	COG1410	methionine synthase
EP379_RS00785	COG0646	methionine synthase
EP379_RS00815	COG0730	response to heat
EP379_RS00820	COG2837	iron assimilation
EP379_RS00830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP379_RS00850	COG1850	ribulose-bisphosphate carboxylase activity
EP379_RS00865	COG4548	von Willebrand factor, type A
EP379_RS00890	COG1850	ribulose-bisphosphate carboxylase activity
EP379_RS00970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EP379_RS00975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EP379_RS00985	COG0742	ribosomal rna small subunit methyltransferase
EP379_RS00990	COG0612	Peptidase, M16
EP379_RS00995	COG0612	Peptidase, M16
EP379_RS01000	COG0552	protein localization to endoplasmic reticulum
EP379_RS01005	COG2884	Cell division ATP-binding protein ftsE
EP379_RS01010	COG2177	Part of the ABC transporter FtsEX involved in
EP379_RS01035	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EP379_RS01040	COG2226	methyltransferase
EP379_RS01045	COG2267	carboxylic ester hydrolase activity
EP379_RS01050	COG0156	8-amino-7-oxononanoate synthase activity
EP379_RS01055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EP379_RS01065	COG1840	ABC-type Fe3 transport system, periplasmic component
EP379_RS01070	COG1178	ABC-type Fe3 transport system permease component
EP379_RS01075	COG3842	ATPase activity
EP379_RS01085	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP379_RS01090	COG3161	chorismate lyase activity
EP379_RS01095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EP379_RS01100	COG4783	chaperone-mediated protein folding
EP379_RS01135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP379_RS01145	COG2703	oxygen carrier activity
EP379_RS01170	COG0107	imidazoleglycerol-phosphate synthase activity
EP379_RS01185	COG0243	molybdopterin cofactor binding
EP379_RS01205	COG4191	Histidine kinase
EP379_RS01210	COG2204	response regulator
EP379_RS01215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EP379_RS01240	COG0175	sulfate reduction
EP379_RS01250	COG0840	transmembrane signaling receptor activity
EP379_RS01270	COG0730	response to heat
EP379_RS01275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP379_RS01290	COG2226	methyltransferase
EP379_RS01310	COG2897	thiosulfate sulfurtransferase activity
EP379_RS01320	COG2391	methyltransferase activity
EP379_RS01370	COG3852	Histidine kinase
EP379_RS01380	COG0840	transmembrane signaling receptor activity
EP379_RS01420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP379_RS01455	COG0701	Predicted permease
EP379_RS01465	COG0798	PFAM Bile acid sodium symporter
EP379_RS01475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP379_RS01480	COG0640	Transcriptional regulator
EP379_RS01485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EP379_RS01490	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EP379_RS01500	COG0194	GDP metabolic process
EP379_RS01505	COG0069	glutamate synthase activity
EP379_RS01505	COG0067	glutamate synthase
EP379_RS01505	COG0070	glutamate synthase
EP379_RS01510	COG0493	'glutamate synthase
EP379_RS01515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EP379_RS01535	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EP379_RS01545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EP379_RS01570	COG1965	Belongs to the frataxin family
EP379_RS01580	COG2010	Cytochrome c
EP379_RS01620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EP379_RS01635	COG2827	Endonuclease containing a URI domain
EP379_RS01640	COG0488	(ABC) transporter
EP379_RS01655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP379_RS01680	COG0011	TIGRFAM Protein of
EP379_RS01690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EP379_RS01760	COG3122	Protein conserved in bacteria
EP379_RS01770	COG1162	GTPase activity
EP379_RS01790	COG0165	Argininosuccinate lyase
EP379_RS01795	COG3275	phosphorelay sensor kinase activity
EP379_RS01820	COG2959	enzyme of heme biosynthesis
EP379_RS01830	COG0543	2 iron, 2 sulfur cluster binding
EP379_RS01830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP379_RS01840	COG1192	Involved in chromosome partitioning
EP379_RS01855	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EP379_RS01860	COG2271	Major facilitator Superfamily
EP379_RS01895	COG2204	response regulator
EP379_RS01905	COG3852	Histidine kinase
EP379_RS01920	COG0840	transmembrane signaling receptor activity
EP379_RS01965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EP379_RS01980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EP379_RS01985	COG0306	phosphate transporter
EP379_RS01990	COG1392	Phosphate transport regulator
EP379_RS02005	COG0826	peptidase U32
EP379_RS02015	COG0385	Bile acid
EP379_RS02025	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EP379_RS02045	COG2226	methyltransferase
EP379_RS02050	COG1714	RDD family
EP379_RS02060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP379_RS02080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EP379_RS02085	COG1242	4 iron, 4 sulfur cluster binding
EP379_RS02090	COG0826	peptidase U32
EP379_RS02095	COG0826	peptidase U32
EP379_RS02100	COG3154	lipid carrier protein
EP379_RS02105	COG2217	Heavy metal translocating P-type atpase
EP379_RS02110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EP379_RS02135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EP379_RS02140	COG0546	phosphoglycolate phosphatase activity
EP379_RS02145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EP379_RS02155	COG2814	Major facilitator Superfamily
EP379_RS02160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP379_RS02165	COG0134	indole-3-glycerol-phosphate synthase activity
EP379_RS02175	COG1765	OsmC-like protein
EP379_RS02180	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EP379_RS02185	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EP379_RS02190	COG0247	lactate metabolic process
EP379_RS02200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EP379_RS02225	COG3549	Plasmid maintenance system killer
EP379_RS02270	COG2226	methyltransferase
EP379_RS02275	COG2852	Protein conserved in bacteria
EP379_RS02280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP379_RS02305	COG1372	Participates in initiation and elongation during chromosome replication
EP379_RS02305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP379_RS02360	COG1253	flavin adenine dinucleotide binding
EP379_RS02365	COG2983	Belongs to the UPF0260 family
EP379_RS02385	COG0826	peptidase U32
EP379_RS02395	COG0791	NLP P60 protein
EP379_RS02400	COG0247	lactate metabolic process
EP379_RS02415	COG0563	adenylate kinase activity
EP379_RS02425	COG0205	6-phosphofructokinase activity
EP379_RS02430	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EP379_RS02435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EP379_RS02450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EP379_RS02455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EP379_RS02460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EP379_RS02470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EP379_RS02490	COG3079	Belongs to the UPF0149 family
EP379_RS02495	COG0006	proline dipeptidase activity
EP379_RS02500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP379_RS02505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP379_RS02515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EP379_RS02520	COG0509	glycine decarboxylation via glycine cleavage system
EP379_RS02525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EP379_RS02530	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EP379_RS02535	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EP379_RS02540	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EP379_RS02545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP379_RS02555	COG0151	Belongs to the GarS family
EP379_RS02570	COG2703	oxygen carrier activity
EP379_RS02580	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EP379_RS02585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP379_RS02605	COG0439	Biotin carboxylase
EP379_RS02610	COG0511	ligase activity, forming carbon-carbon bonds
EP379_RS02615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EP379_RS02620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP379_RS02625	COG4232	protein-disulfide reductase activity
EP379_RS02630	COG1324	tolerance protein
EP379_RS02635	COG3030	protein affecting phage T7 exclusion by the F plasmid
EP379_RS02640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EP379_RS02645	COG0459	protein refolding
EP379_RS02650	COG3039	Transposase
EP379_RS02665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EP379_RS02680	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EP379_RS02680	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EP379_RS02690	COG0667	Aldo Keto reductase
EP379_RS02700	COG0463	Glycosyl transferase, family 2
EP379_RS02705	COG0438	transferase activity, transferring glycosyl groups
EP379_RS02710	COG0859	PFAM glycosyl transferase family 9
EP379_RS02715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP379_RS02720	COG1216	Glycosyl transferase, family 2
EP379_RS02740	COG0859	PFAM glycosyl transferase family 9
EP379_RS02745	COG0859	PFAM glycosyl transferase family 9
EP379_RS02750	COG3642	lipopolysaccharide core region biosynthetic process
EP379_RS02755	COG1519	Transferase
EP379_RS02760	COG1560	Kdo2-lipid A biosynthetic process
EP379_RS02775	COG1538	Outer membrane efflux protein
EP379_RS02780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EP379_RS02810	COG1187	pseudouridine synthase activity
EP379_RS02815	COG2813	Specifically methylates the guanine in position
EP379_RS02820	COG1278	Cold shock
EP379_RS02825	COG0724	RNA recognition motif
EP379_RS02840	COG0514	ATP-dependent DNA helicase (RecQ)
EP379_RS02855	COG2226	methyltransferase
EP379_RS02860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP379_RS02875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EP379_RS02885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP379_RS02915	COG0778	Nitroreductase
EP379_RS02930	COG0315	cyclic pyranopterin monophosphate synthase activity
EP379_RS02935	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EP379_RS02940	COG0314	molybdopterin synthase activity
EP379_RS02955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EP379_RS02960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EP379_RS02970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP379_RS02985	COG0586	Pfam SNARE associated Golgi protein
EP379_RS03005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP379_RS03010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EP379_RS03015	COG0352	thiamine-phosphate diphosphorylase activity
EP379_RS03030	COG0352	thiamine-phosphate diphosphorylase activity
EP379_RS03030	COG0351	phosphomethylpyrimidine kinase
EP379_RS03065	COG3659	wide pore channel activity
EP379_RS03070	COG4633	Protein conserved in bacteria
EP379_RS03105	COG4771	TonB-dependent receptor
EP379_RS03140	COG2193	ferroxidase activity
EP379_RS03145	COG1858	cytochrome C peroxidase
EP379_RS03150	COG1981	membrane
EP379_RS03160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EP379_RS03175	COG0316	Belongs to the HesB IscA family
EP379_RS03185	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EP379_RS03190	COG0739	heme binding
EP379_RS03250	COG0589	response to stress
EP379_RS03260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EP379_RS03290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EP379_RS03300	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EP379_RS03310	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EP379_RS03315	COG0081	regulation of translation
EP379_RS03320	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EP379_RS03325	COG0222	ribosome binding
EP379_RS03330	COG0085	RNA polymerase activity
EP379_RS03335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EP379_RS03340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EP379_RS03345	COG0049	tRNA binding
EP379_RS03350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EP379_RS03355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EP379_RS03360	COG0051	transcription antitermination factor activity, RNA binding
EP379_RS03365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EP379_RS03370	COG0088	Forms part of the polypeptide exit tunnel
EP379_RS03375	COG0089	rRNA binding
EP379_RS03380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EP379_RS03385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EP379_RS03390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EP379_RS03395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EP379_RS03400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EP379_RS03405	COG0255	Belongs to the universal ribosomal protein uL29 family
EP379_RS03415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EP379_RS03420	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EP379_RS03425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EP379_RS03430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EP379_RS03435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EP379_RS03440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EP379_RS03445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EP379_RS03450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EP379_RS03460	COG0200	Binds to the 23S rRNA
EP379_RS03465	COG0201	protein transport
EP379_RS03475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EP379_RS03480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EP379_RS03485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EP379_RS03490	COG0202	RNA polymerase activity
EP379_RS03510	COG2814	Major facilitator Superfamily
EP379_RS03515	COG0629	single-stranded DNA binding
EP379_RS03525	COG0142	geranyltranstransferase activity
EP379_RS03530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EP379_RS03535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EP379_RS03540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EP379_RS03550	COG0268	Binds directly to 16S ribosomal RNA
EP379_RS03555	COG0728	peptidoglycan biosynthetic process
EP379_RS03560	COG0196	riboflavin kinase activity
EP379_RS03565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EP379_RS03575	COG1047	Peptidyl-prolyl cis-trans
EP379_RS03580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EP379_RS03625	COG0735	belongs to the Fur family
EP379_RS03650	COG1115	amino acid carrier protein
EP379_RS03690	COG0589	response to stress
EP379_RS03705	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EP379_RS03715	COG3851	Histidine kinase
EP379_RS03720	COG2197	response regulator
EP379_RS03725	COG2197	response regulator
EP379_RS03735	COG5001	Diguanylate cyclase
EP379_RS03735	COG3300	MHYT domain
EP379_RS03745	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EP379_RS03750	COG0308	aminopeptidase N
EP379_RS03795	COG0653	protein targeting
EP379_RS03800	COG1203	CRISPR-associated helicase, Cas3
EP379_RS03815	COG1857	crispr-associated protein
EP379_RS03840	COG1518	maintenance of DNA repeat elements
EP379_RS03845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EP379_RS03850	COG3039	Transposase
EP379_RS03875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EP379_RS03890	COG2096	Adenosyltransferase
EP379_RS03900	COG4206	TonB-dependent receptor
EP379_RS03905	COG0729	surface antigen
EP379_RS03910	COG2911	Protein conserved in bacteria
EP379_RS03930	COG0330	HflC and HflK could
EP379_RS03940	COG2862	Uncharacterized protein family, UPF0114
EP379_RS03960	COG3210	domain, Protein
EP379_RS03985	COG1752	Esterase of the alpha-beta hydrolase superfamily
EP379_RS03995	COG3956	TIGRFAM MazG family protein
EP379_RS04000	COG0004	ammonium transporteR
EP379_RS04005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP379_RS04010	COG1136	(ABC) transporter
EP379_RS04030	COG1702	phosphate starvation-inducible protein PhoH
EP379_RS04035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EP379_RS04040	COG4535	Mg2 and Co2 transporter CorC
EP379_RS04045	COG1968	undecaprenyl-diphosphatase activity
EP379_RS04060	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EP379_RS04080	COG0495	leucyl-tRNA aminoacylation
EP379_RS04095	COG1595	DNA-templated transcription, initiation
EP379_RS04145	COG5001	Diguanylate cyclase
EP379_RS04145	COG3447	MASE1 domain protein
EP379_RS04145	COG5002	protein histidine kinase activity
EP379_RS04155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EP379_RS04160	COG0343	queuine tRNA-ribosyltransferase activity
EP379_RS04170	COG1862	Preprotein translocase
EP379_RS04175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP379_RS04180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP379_RS04185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP379_RS04210	COG1104	cysteine desulfurase activity
EP379_RS04220	COG0822	iron-sulfur transferase activity
EP379_RS04250	COG0105	UTP biosynthetic process
EP379_RS04255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EP379_RS04260	COG3063	Type IV pilus biogenesis stability protein PilW
EP379_RS04270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EP379_RS04275	COG0124	histidyl-tRNA synthetase
EP379_RS04280	COG2976	Protein conserved in bacteria
EP379_RS04285	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP379_RS04290	COG1160	GTP binding
EP379_RS04315	COG1570	exodeoxyribonuclease VII activity
EP379_RS04320	COG0557	exoribonuclease II activity
EP379_RS04325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP379_RS04330	COG0360	Binds together with S18 to 16S ribosomal RNA
EP379_RS04335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EP379_RS04345	COG0359	binds to the 23S rRNA
EP379_RS04350	COG0305	Participates in initiation and elongation during chromosome replication
EP379_RS04355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EP379_RS04385	COG4536	flavin adenine dinucleotide binding
EP379_RS04390	COG4137	Cytochrome C assembly protein
EP379_RS04395	COG1234	tRNA 3'-trailer cleavage
EP379_RS04400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EP379_RS04405	COG0228	four-way junction DNA binding
EP379_RS04410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EP379_RS04420	COG0335	large ribosomal subunit rRNA binding
EP379_RS04440	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EP379_RS04445	COG1666	GTP binding
EP379_RS04455	COG3118	belongs to the thioredoxin family
EP379_RS04460	COG1074	ATP-dependent DNA helicase activity
EP379_RS04495	COG0300	oxidoreductase activity
EP379_RS04560	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EP379_RS04565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EP379_RS04585	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EP379_RS04590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EP379_RS04595	COG2137	regulation of response to DNA damage stimulus
EP379_RS04600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EP379_RS04605	COG0527	aspartate kinase activity
EP379_RS04610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EP379_RS04625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP379_RS04630	COG0438	transferase activity, transferring glycosyl groups
EP379_RS04635	COG0438	transferase activity, transferring glycosyl groups
EP379_RS04645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EP379_RS04650	COG0835	chemotaxis
EP379_RS04650	COG0784	Response regulator, receiver
EP379_RS04700	COG0348	domain, Protein
EP379_RS04725	COG1999	signal sequence binding
EP379_RS04735	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP379_RS04740	COG2863	cytochrome
EP379_RS04750	COG3005	denitrification pathway
EP379_RS04775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EP379_RS04785	COG4787	bacterial-type flagellum-dependent cell motility
EP379_RS04795	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EP379_RS04800	COG1706	bacterial-type flagellum-dependent cell motility
EP379_RS04815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EP379_RS04820	COG0859	PFAM glycosyl transferase family 9
EP379_RS04820	COG0457	Tetratricopeptide repeat
EP379_RS04830	COG1334	flagellar protein FlaG
EP379_RS04840	COG3039	Transposase
EP379_RS04900	COG2882	bacterial-type flagellum organization
EP379_RS04935	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EP379_RS04950	COG0501	Belongs to the peptidase M48B family
EP379_RS04955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP379_RS04970	COG4555	ABC transporter
EP379_RS05060	COG0789	Transcriptional regulator
EP379_RS05085	COG0583	DNA-binding transcription factor activity
EP379_RS05090	COG1309	transcriptional regulator
EP379_RS05100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP379_RS05105	COG1131	(ABC) transporter
EP379_RS05110	COG0842	Transport permease protein
EP379_RS05115	COG0842	Transport permease protein
EP379_RS05130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EP379_RS05135	COG1611	Belongs to the LOG family
EP379_RS05170	COG2801	Transposase and inactivated derivatives
EP379_RS05190	COG3772	lysozyme
EP379_RS05255	COG1487	ribonuclease activity
EP379_RS05365	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EP379_RS05370	COG1475	DNA binding
EP379_RS05405	COG1061	Type III restriction enzyme res subunit
EP379_RS05500	COG2894	cell division
EP379_RS05535	COG0776	regulation of translation
EP379_RS05555	COG1475	DNA binding
EP379_RS05595	COG2003	Belongs to the UPF0758 family
EP379_RS05620	COG3047	cAMP biosynthetic process
EP379_RS05620	COG2885	chlorophyll binding
EP379_RS05670	COG0681	Belongs to the peptidase S26 family
EP379_RS05775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EP379_RS05780	COG0733	neurotransmitter:sodium symporter activity
EP379_RS05790	COG2914	Belongs to the UPF0125 (RnfH) family
EP379_RS05795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP379_RS05800	COG0735	belongs to the Fur family
EP379_RS05810	COG0497	DNA recombination
EP379_RS05815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EP379_RS05820	COG1420	regulation of RNA biosynthetic process
EP379_RS05825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EP379_RS05830	COG0443	Heat shock 70 kDa protein
EP379_RS05835	COG0484	heat shock protein binding
EP379_RS05845	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EP379_RS05850	COG0505	Belongs to the CarA family
EP379_RS05860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP379_RS05870	COG1534	Rna-binding protein
EP379_RS05875	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EP379_RS05880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP379_RS05885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EP379_RS05890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP379_RS05895	COG0149	triose-phosphate isomerase activity
EP379_RS05910	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP379_RS05915	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP379_RS05920	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP379_RS05925	COG0649	NAD binding
EP379_RS05930	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EP379_RS05935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EP379_RS05940	COG1034	ATP synthesis coupled electron transport
EP379_RS05945	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EP379_RS05960	COG0713	ATP synthesis coupled electron transport
EP379_RS05975	COG1007	ATP synthesis coupled electron transport
EP379_RS05995	COG0195	Participates in both transcription termination and antitermination
EP379_RS06000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EP379_RS06015	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EP379_RS06020	COG1185	polyribonucleotide nucleotidyltransferase activity
EP379_RS06035	COG0235	Class ii aldolase
EP379_RS06040	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EP379_RS06060	COG1309	transcriptional regulator
EP379_RS06065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EP379_RS06070	COG0505	Belongs to the CarA family
EP379_RS06080	COG2204	response regulator
EP379_RS06090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP379_RS06105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP379_RS06120	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EP379_RS06135	COG2204	response regulator
EP379_RS06140	COG3852	Histidine kinase
EP379_RS06160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EP379_RS06180	COG0436	Aminotransferase
EP379_RS06215	COG0529	Catalyzes the synthesis of activated sulfate
EP379_RS06225	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EP379_RS06225	COG0662	Cupin 2, conserved barrel domain protein
EP379_RS06245	COG0438	transferase activity, transferring glycosyl groups
EP379_RS06255	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EP379_RS06275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP379_RS06285	COG2801	Transposase and inactivated derivatives
EP379_RS06345	COG1320	monovalent cation:proton antiporter activity
EP379_RS06350	COG2212	antiporter activity
EP379_RS06355	COG1863	multisubunit Na H antiporter MnhE subunit
EP379_RS06360	COG0651	ATP synthesis coupled electron transport
EP379_RS06365	COG1006	Multisubunit Na H antiporter MnhC subunit
EP379_RS06370	COG2111	Na H antiporter
EP379_RS06370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EP379_RS06380	COG4133	protoheme IX ABC transporter activity
EP379_RS06385	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP379_RS06400	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EP379_RS06405	COG1138	Cytochrome C-type biogenesis protein
EP379_RS06410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP379_RS06430	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP379_RS06435	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
EP379_RS06435	COG3261	NADH dehydrogenase
EP379_RS06440	COG0651	ATP synthesis coupled electron transport
EP379_RS06455	COG0651	ATP synthesis coupled electron transport
EP379_RS06475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP379_RS06490	COG1643	Atp-dependent helicase
EP379_RS06530	COG1704	LemA family
EP379_RS06555	COG1199	ATP-dependent helicase activity
EP379_RS06575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EP379_RS06580	COG1393	Belongs to the ArsC family
EP379_RS06585	COG2171	N-acyltransferase activity
EP379_RS06590	COG0436	Aminotransferase
EP379_RS06600	COG4591	ABC-type transport system involved in lipoprotein release permease component
EP379_RS06605	COG1136	(ABC) transporter
EP379_RS06620	COG0811	peptide transport
EP379_RS06625	COG0848	biopolymer transport protein
EP379_RS06630	COG1132	(ABC) transporter
EP379_RS06635	COG1663	tetraacyldisaccharide 4'-kinase activity
EP379_RS06640	COG1663	tetraacyldisaccharide 4'-kinase activity
EP379_RS06640	COG2835	tetraacyldisaccharide 4'-kinase activity
EP379_RS06645	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EP379_RS06655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP379_RS06660	COG1530	ribonuclease E activity
EP379_RS06665	COG0564	pseudouridine synthase activity
EP379_RS06675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EP379_RS06675	COG0616	signal peptide processing
EP379_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
EP379_RS06685	COG1233	COG1233 Phytoene dehydrogenase and related
EP379_RS06690	COG1562	ergosterol biosynthetic process
EP379_RS06695	COG1562	ergosterol biosynthetic process
EP379_RS06705	COG1322	Protein conserved in bacteria
EP379_RS06710	COG0546	phosphoglycolate phosphatase activity
EP379_RS06720	COG0402	S-adenosylhomocysteine deaminase activity
EP379_RS06730	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EP379_RS06740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EP379_RS06745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP379_RS06750	COG0077	Prephenate dehydratase
EP379_RS06750	COG1605	Chorismate mutase
EP379_RS06755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP379_RS06760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EP379_RS06765	COG0287	Prephenate dehydrogenase
EP379_RS06770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EP379_RS06775	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EP379_RS06785	COG0776	regulation of translation
EP379_RS06795	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EP379_RS06800	COG0284	orotidine-5'-phosphate decarboxylase activity
EP379_RS06805	COG1555	photosystem II stabilization
EP379_RS06825	COG0436	Aminotransferase
EP379_RS06845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP379_RS06860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP379_RS06880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP379_RS06900	COG1215	transferase activity, transferring glycosyl groups
EP379_RS06905	COG0596	Alpha beta hydrolase
EP379_RS06905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EP379_RS06910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EP379_RS06920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EP379_RS06925	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EP379_RS06930	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EP379_RS06935	COG0072	phenylalanine-tRNA ligase activity
EP379_RS07025	COG0535	radical SAM domain protein
EP379_RS07070	COG2010	Cytochrome c
EP379_RS07075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP379_RS07100	COG0714	Associated with various cellular activities
EP379_RS07110	COG1845	cytochrome c oxidase, subunit III
EP379_RS07120	COG2010	Cytochrome c
EP379_RS07165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EP379_RS07165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EP379_RS07165	COG1013	pyruvate-flavodoxin oxidoreductase activity
EP379_RS07165	COG0674	pyruvate-flavodoxin oxidoreductase activity
EP379_RS07170	COG0123	including yeast histone deacetylase and acetoin utilization protein
EP379_RS07175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EP379_RS07175	COG1042	CoA-binding domain protein
EP379_RS07175	COG0045	succinate-CoA ligase (ADP-forming) activity
EP379_RS07180	COG0700	Nucleoside recognition
EP379_RS07195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EP379_RS07195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EP379_RS07200	COG2915	High frequency lysogenization protein hflD homolog
EP379_RS07205	COG0482	sulfurtransferase activity
EP379_RS07220	COG5002	protein histidine kinase activity
EP379_RS07220	COG5001	Diguanylate cyclase
EP379_RS07235	COG0436	Aminotransferase
EP379_RS07240	COG0436	Aminotransferase
EP379_RS07250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EP379_RS07260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EP379_RS07280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EP379_RS07285	COG1480	7TM receptor with intracellular HD hydrolase
EP379_RS07305	COG1053	succinate dehydrogenase
EP379_RS07340	COG3026	antisigma factor binding
EP379_RS07350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP379_RS07360	COG0481	GTPase activity
EP379_RS07375	COG0571	ribonuclease III activity
EP379_RS07380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EP379_RS07385	COG1381	Involved in DNA repair and RecF pathway recombination
EP379_RS07390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EP379_RS07395	COG0736	holo-[acyl-carrier-protein] synthase activity
EP379_RS07405	COG1454	alcohol dehydrogenase
EP379_RS07420	COG0840	transmembrane signaling receptor activity
EP379_RS07440	COG2153	protein acetylation
EP379_RS07445	COG2850	peptidyl-arginine hydroxylation
EP379_RS07450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EP379_RS07470	COG2354	Protein conserved in bacteria
EP379_RS07510	COG0584	glycerophosphoryl diester phosphodiesterase
EP379_RS07515	COG2198	Histidine kinase
EP379_RS07515	COG2205	protein histidine kinase activity
EP379_RS07515	COG0784	Response regulator, receiver
EP379_RS07525	COG0741	lytic transglycosylase activity
EP379_RS07545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EP379_RS07550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EP379_RS07555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EP379_RS07595	COG0084	hydrolase, TatD family'
EP379_RS07610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EP379_RS07625	COG2920	part of a sulfur-relay system
EP379_RS07645	COG2221	Nitrite and sulphite reductase 4Fe-4S
EP379_RS07650	COG2221	Nitrite and sulphite reductase 4Fe-4S
EP379_RS07655	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EP379_RS07660	COG2923	Belongs to the DsrF TusC family
EP379_RS07670	COG2920	part of a sulfur-relay system
EP379_RS07705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP379_RS07710	COG1797	cobyrinic acid a,c-diamide synthase activity
EP379_RS07720	COG3850	Histidine kinase
EP379_RS07725	COG2197	response regulator
EP379_RS07740	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EP379_RS07745	COG0668	transmembrane transport
EP379_RS07750	COG1472	Belongs to the glycosyl hydrolase 3 family
EP379_RS07760	COG1376	ErfK ybiS ycfS ynhG family protein
EP379_RS07765	COG2954	triphosphatase activity
EP379_RS07775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP379_RS07780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EP379_RS07800	COG1830	Aldolase
EP379_RS07805	COG1376	ErfK ybiS ycfS ynhG family protein
EP379_RS07810	COG3437	response regulator, receiver
EP379_RS07810	COG0784	Response regulator, receiver
EP379_RS07815	COG0742	ribosomal rna small subunit methyltransferase
EP379_RS07820	COG0583	DNA-binding transcription factor activity
EP379_RS07825	COG2878	Part of a membrane complex involved in electron transport
EP379_RS07830	COG0674	pyruvate-flavodoxin oxidoreductase activity
EP379_RS07830	COG1013	pyruvate-flavodoxin oxidoreductase activity
EP379_RS07830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EP379_RS07830	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EP379_RS07830	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EP379_RS07830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EP379_RS07830	COG0674	pyruvate-flavodoxin oxidoreductase activity
EP379_RS07830	COG1013	pyruvate-flavodoxin oxidoreductase activity
EP379_RS07835	COG4656	Part of a membrane complex involved in electron transport
EP379_RS07840	COG4658	electron transport chain
EP379_RS07845	COG4659	FMN binding
EP379_RS07850	COG4660	Part of a membrane complex involved in electron transport
EP379_RS07855	COG4657	Part of a membrane complex involved in electron transport
EP379_RS07870	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EP379_RS07890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EP379_RS07895	COG0322	excinuclease ABC activity
EP379_RS07920	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EP379_RS07925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP379_RS07930	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EP379_RS07935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EP379_RS07945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EP379_RS07950	COG0542	response to heat
EP379_RS07955	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EP379_RS07970	COG1238	metal cluster binding
EP379_RS07975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EP379_RS07980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EP379_RS07985	COG2840	Smr protein MutS2
EP379_RS07990	COG0585	pseudouridine synthase activity
EP379_RS07995	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EP379_RS08000	COG0513	Belongs to the DEAD box helicase family
EP379_RS08005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EP379_RS08010	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EP379_RS08015	COG0148	phosphopyruvate hydratase activity
EP379_RS08020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EP379_RS08025	COG0504	CTP synthase activity
EP379_RS08030	COG0037	tRNA processing
EP379_RS08035	COG0825	malonyl-CoA metabolic process
EP379_RS08060	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP379_RS08065	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP379_RS08070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EP379_RS08075	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP379_RS08095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EP379_RS08105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EP379_RS08110	COG0233	cytoplasmic translational termination
EP379_RS08115	COG0528	UMP kinase activity
EP379_RS08120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EP379_RS08125	COG0052	Belongs to the universal ribosomal protein uS2 family
EP379_RS08130	COG0024	Methionine aminopeptidase
EP379_RS08135	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EP379_RS08140	COG2226	methyltransferase
EP379_RS08145	COG2226	methyltransferase
EP379_RS08155	COG1489	DNA binding
EP379_RS08160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP379_RS08165	COG0583	DNA-binding transcription factor activity
EP379_RS08170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP379_RS08175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP379_RS08190	COG2957	Belongs to the agmatine deiminase family
EP379_RS08195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP379_RS08200	COG1605	Chorismate mutase
EP379_RS08200	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EP379_RS08210	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP379_RS08215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EP379_RS08250	COG1047	Peptidyl-prolyl cis-trans
EP379_RS08260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP379_RS08265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP379_RS08265	COG1648	precorrin-2 dehydrogenase activity
EP379_RS08280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EP379_RS08285	COG1993	acr, cog1993
EP379_RS08290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EP379_RS08295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EP379_RS08300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EP379_RS08305	COG1674	ftsk spoiiie
EP379_RS08310	COG0686	Belongs to the AlaDH PNT family
EP379_RS08315	COG0492	ferredoxin-NADP+ reductase activity
EP379_RS08320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EP379_RS08325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EP379_RS08330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP379_RS08335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP379_RS08340	COG1028	Short-chain dehydrogenase reductase Sdr
EP379_RS08350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EP379_RS08355	COG0416	fatty acid biosynthetic process
EP379_RS08360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EP379_RS08365	COG1399	metal-binding, possibly nucleic acid-binding protein
EP379_RS08370	COG0439	Biotin carboxylase
EP379_RS08375	COG0511	ligase activity, forming carbon-carbon bonds
EP379_RS08375	COG5016	pyruvate
EP379_RS08380	COG0424	maF-like protein
EP379_RS08390	COG3706	GGDEF domain
EP379_RS08395	COG0590	tRNA wobble adenosine to inosine editing
EP379_RS08410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EP379_RS08420	COG0180	Tryptophanyl-tRNA synthetase
EP379_RS08425	COG1994	Peptidase M50
EP379_RS08430	COG0009	L-threonylcarbamoyladenylate synthase
EP379_RS08435	COG0613	PHP domain protein
EP379_RS08440	COG2917	probably involved in intracellular septation
EP379_RS08445	COG2350	Protein conserved in bacteria
EP379_RS08455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP379_RS08485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EP379_RS08490	COG3115	cell septum assembly
EP379_RS08495	COG1196	nuclear chromosome segregation
EP379_RS08500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EP379_RS08510	COG1070	Carbohydrate kinase
EP379_RS08515	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EP379_RS08520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EP379_RS08530	COG1309	transcriptional regulator
EP379_RS08550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EP379_RS08555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EP379_RS08580	COG2151	metal-sulfur cluster biosynthetic enzyme
EP379_RS08590	COG0840	transmembrane signaling receptor activity
EP379_RS08595	COG1845	cytochrome c oxidase, subunit III
EP379_RS08605	COG0835	chemotaxis
EP379_RS08605	COG0784	Response regulator, receiver
EP379_RS08610	COG0835	chemotaxis
EP379_RS08620	COG0328	RNA-DNA hybrid ribonuclease activity
EP379_RS08630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP379_RS08635	COG0741	lytic transglycosylase activity
EP379_RS08635	COG1388	LysM domain
EP379_RS08640	COG4172	Belongs to the ABC transporter superfamily
EP379_RS08645	COG4239	(ABC) transporter, permease
EP379_RS08650	COG4174	ABC transporter (Permease)
EP379_RS08655	COG4166	transmembrane transport
EP379_RS08660	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EP379_RS08665	COG1301	dicarboxylic acid transport
EP379_RS08670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP379_RS08685	COG0776	regulation of translation
EP379_RS08690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP379_RS08700	COG0740	serine-type endopeptidase activity
EP379_RS08705	COG0544	peptidyl-prolyl cis-trans isomerase activity
EP379_RS08720	COG2204	response regulator
EP379_RS08735	COG0848	biopolymer transport protein
EP379_RS08740	COG0811	peptide transport
EP379_RS08745	COG4771	TonB-dependent receptor
EP379_RS08760	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
EP379_RS08795	COG1704	LemA family
EP379_RS08820	COG0676	glucose-6-phosphate 1-epimerase activity
EP379_RS08830	COG0215	cysteine-tRNA ligase activity
EP379_RS08840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP379_RS08845	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP379_RS08855	COG2833	Protein of unknown function (DUF455)
EP379_RS08860	COG2379	hydroxypyruvate reductase
EP379_RS08865	COG0724	RNA recognition motif
EP379_RS08880	COG1286	toxin biosynthetic process
EP379_RS08890	COG0285	dihydrofolate synthase activity
EP379_RS08895	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EP379_RS08900	COG0159	tryptophan synthase activity
EP379_RS08905	COG0133	tryptophan synthase activity
EP379_RS08910	COG0135	phosphoribosylanthranilate isomerase activity
EP379_RS08935	COG0473	3-isopropylmalate dehydrogenase activity
EP379_RS08945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EP379_RS08960	COG2814	Major facilitator Superfamily
EP379_RS08965	COG3128	pkhd-type hydroxylase
EP379_RS08970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EP379_RS08990	COG0521	Mo-molybdopterin cofactor biosynthetic process
EP379_RS09005	COG1355	regulation of microtubule-based process
EP379_RS09025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP379_RS09040	COG0835	chemotaxis
EP379_RS09050	COG1192	Involved in chromosome partitioning
EP379_RS09060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EP379_RS09070	COG0643	Histidine kinase
EP379_RS09070	COG0784	Response regulator, receiver
EP379_RS09070	COG2198	Histidine kinase
EP379_RS09075	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EP379_RS09100	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP379_RS09105	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EP379_RS09155	COG2154	pterin-4-alpha-carbinolamine dehydratase
EP379_RS09160	COG1162	GTPase activity
EP379_RS09165	COG1360	Flagellar Motor Protein
EP379_RS09180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EP379_RS09185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EP379_RS09210	COG0582	viral genome integration into host DNA
EP379_RS09240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EP379_RS09280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EP379_RS09290	COG3830	Belongs to the UPF0237 family
EP379_RS09290	COG0560	Phosphoserine phosphatase
EP379_RS09305	COG3210	domain, Protein
EP379_RS09335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EP379_RS09335	COG0519	Catalyzes the synthesis of GMP from XMP
EP379_RS09340	COG5001	Diguanylate cyclase
EP379_RS09340	COG5002	protein histidine kinase activity
EP379_RS09345	COG4106	trans-aconitate 2-methyltransferase activity
EP379_RS09350	COG0500	methyltransferase
EP379_RS09355	COG0516	GMP reductase activity
EP379_RS09355	COG0517	IMP dehydrogenase activity
EP379_RS09365	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EP379_RS09365	COG0493	'glutamate synthase
EP379_RS09380	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EP379_RS09385	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EP379_RS09390	COG0330	HflC and HflK could
EP379_RS09395	COG0330	HflC and HflK could
EP379_RS09400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EP379_RS09405	COG1923	regulation of RNA biosynthetic process
EP379_RS09415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EP379_RS09420	COG0860	N-Acetylmuramoyl-L-alanine amidase
EP379_RS09425	COG0802	atpase or kinase
EP379_RS09430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EP379_RS09430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EP379_RS09460	COG0494	nUDIX hydrolase
EP379_RS09470	COG1763	Mo-molybdopterin cofactor biosynthetic process
EP379_RS09485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EP379_RS09490	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EP379_RS09500	COG3864	Putative metallopeptidase domain
EP379_RS09510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP379_RS09520	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EP379_RS09540	COG0326	Molecular chaperone. Has ATPase activity
EP379_RS09545	COG0033	Phosphoglucomutase
EP379_RS09550	COG0574	Belongs to the PEP-utilizing enzyme family
EP379_RS09550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EP379_RS09555	COG1509	lysine 2,3-aminomutase activity
EP379_RS09565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EP379_RS09570	COG1999	signal sequence binding
EP379_RS09575	COG0688	phosphatidylethanolamine metabolic process
EP379_RS09595	COG0501	Belongs to the peptidase M48B family
EP379_RS09615	COG0745	RESPONSE REGULATOR receiver
EP379_RS09640	COG1234	tRNA 3'-trailer cleavage
EP379_RS09645	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EP379_RS09650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP379_RS09655	COG2716	regulation of RNA biosynthetic process
EP379_RS09660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP379_RS09665	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EP379_RS09705	COG0488	(ABC) transporter
EP379_RS09715	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
EP379_RS09720	COG1067	ATP-dependent peptidase activity
EP379_RS09730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EP379_RS09785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EP379_RS09805	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
EP379_RS09825	COG3287	FIST C domain
EP379_RS09825	COG2200	EAL domain
EP379_RS09825	COG2199	diguanylate cyclase activity
EP379_RS09865	COG2105	PFAM AIG2 family protein
EP379_RS09885	COG4657	Part of a membrane complex involved in electron transport
EP379_RS09890	COG2878	Part of a membrane complex involved in electron transport
EP379_RS09895	COG4656	Part of a membrane complex involved in electron transport
EP379_RS09900	COG4658	electron transport chain
EP379_RS09965	COG0456	acetyltransferase
EP379_RS09975	COG3411	Ferredoxin
EP379_RS09980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EP379_RS10010	COG0589	response to stress
EP379_RS10015	COG0659	secondary active sulfate transmembrane transporter activity
EP379_RS10045	COG2205	protein histidine kinase activity
EP379_RS10070	COG3100	YcgL domain-containing protein
EP379_RS10100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EP379_RS10125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EP379_RS10130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EP379_RS10150	COG1722	exodeoxyribonuclease VII activity
EP379_RS10155	COG0142	geranyltranstransferase activity
EP379_RS10160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EP379_RS10165	COG0720	synthase
EP379_RS10170	COG1469	GTP cyclohydrolase I activity
EP379_RS10180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EP379_RS10185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EP379_RS10195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EP379_RS10210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP379_RS10210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP379_RS10215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EP379_RS10235	COG2210	Belongs to the sulfur carrier protein TusA family
EP379_RS10240	COG0425	Belongs to the sulfur carrier protein TusA family
EP379_RS10245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EP379_RS10250	COG4783	chaperone-mediated protein folding
EP379_RS10270	COG3258	Cytochrome c
EP379_RS10275	COG0471	metal ion transport
EP379_RS10275	COG3273	potassium ion transport
EP379_RS10290	COG1331	Highly conserved protein containing a thioredoxin domain
EP379_RS10315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP379_RS10320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EP379_RS10325	COG4654	Cytochrome c, class I
EP379_RS10330	COG3383	formate dehydrogenase (NAD+) activity
EP379_RS10340	COG1858	cytochrome C peroxidase
EP379_RS10345	COG1858	cytochrome C peroxidase
EP379_RS10370	COG0535	radical SAM domain protein
EP379_RS10380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP379_RS10405	COG2204	response regulator
EP379_RS10410	COG3852	Histidine kinase
EP379_RS10420	COG2801	Transposase and inactivated derivatives
EP379_RS10435	COG0602	queuosine metabolic process
EP379_RS10440	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EP379_RS10450	COG0823	Involved in the tonB-independent uptake of proteins
EP379_RS10470	COG0824	Thioesterase
EP379_RS10475	COG2255	four-way junction helicase activity
EP379_RS10480	COG0632	four-way junction helicase activity
EP379_RS10485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EP379_RS10490	COG0217	transcriptional regulatory protein
EP379_RS10505	COG0631	protein serine/threonine phosphatase activity
EP379_RS10510	COG2815	serine threonine protein kinase
EP379_RS10510	COG0515	serine threonine protein kinase
EP379_RS10515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EP379_RS10520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EP379_RS10540	COG5265	(ABC) transporter
EP379_RS10545	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EP379_RS10550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EP379_RS10565	COG0300	oxidoreductase activity
EP379_RS10575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EP379_RS10575	COG4797	methyltransferase
EP379_RS10600	COG1595	DNA-templated transcription, initiation
EP379_RS10605	COG0084	hydrolase, TatD family'
EP379_RS10615	COG1131	(ABC) transporter
EP379_RS10620	COG0842	Transport permease protein
EP379_RS10625	COG2703	oxygen carrier activity
EP379_RS10640	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EP379_RS10645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EP379_RS10660	COG1573	uracil-dna glycosylase
EP379_RS10665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP379_RS10670	COG1183	phosphatidylcholine synthase activity
EP379_RS10675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EP379_RS10680	COG0440	acetolactate synthase activity
EP379_RS10685	COG0028	Belongs to the TPP enzyme family
EP379_RS10700	COG0442	prolyl-tRNA aminoacylation
EP379_RS10705	COG0741	lytic transglycosylase activity
EP379_RS10710	COG1254	Belongs to the acylphosphatase family
EP379_RS10715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP379_RS10730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP379_RS10740	COG1393	Belongs to the ArsC family
EP379_RS10760	COG0628	permease
EP379_RS10765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EP379_RS10775	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EP379_RS10780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EP379_RS10825	COG1773	rubredoxin
EP379_RS10830	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EP379_RS10835	COG0298	carbon dioxide binding
EP379_RS10840	COG0375	protein maturation
EP379_RS10845	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EP379_RS10870	COG1515	deoxyribonuclease V activity
EP379_RS10875	COG3118	belongs to the thioredoxin family
EP379_RS10880	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EP379_RS10885	COG0590	tRNA wobble adenosine to inosine editing
EP379_RS10885	COG0037	tRNA processing
EP379_RS10890	COG1309	transcriptional regulator
EP379_RS10895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP379_RS10905	COG1136	(ABC) transporter
EP379_RS10905	COG0577	efflux transmembrane transporter activity
EP379_RS10910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EP379_RS10935	COG0668	transmembrane transport
EP379_RS10945	COG0542	response to heat
EP379_RS10950	COG0204	Acyl-transferase
EP379_RS10955	COG0242	peptide deformylase activity
EP379_RS10960	COG3830	Belongs to the UPF0237 family
EP379_RS10975	COG0564	pseudouridine synthase activity
EP379_RS11000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EP379_RS11005	COG0045	succinate-CoA ligase (ADP-forming) activity
EP379_RS11035	COG4969	Belongs to the N-Me-Phe pilin family
EP379_RS11055	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EP379_RS11060	COG0237	dephospho-CoA kinase activity
EP379_RS11065	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EP379_RS11070	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EP379_RS11085	COG0653	protein targeting
EP379_RS11090	COG0739	heme binding
EP379_RS11095	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
EP379_RS11100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EP379_RS11105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EP379_RS11120	COG1181	Belongs to the D-alanine--D-alanine ligase family
EP379_RS11125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EP379_RS11135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EP379_RS11140	COG0772	Belongs to the SEDS family
EP379_RS11145	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EP379_RS11150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EP379_RS11155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EP379_RS11160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EP379_RS11170	COG3116	cell division
EP379_RS11175	COG0275	rRNA processing
EP379_RS11195	COG3107	peptidoglycan biosynthetic process
EP379_RS11200	COG0792	nuclease activity
EP379_RS11205	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EP379_RS11210	COG2823	Periplasmic or secreted lipoprotein
EP379_RS11215	COG0277	FAD linked oxidase domain protein
EP379_RS11220	COG2969	positive regulation of protein catabolic process
EP379_RS11225	COG0625	glutathione transferase activity
EP379_RS11230	COG2857	Cytochrome c1
EP379_RS11235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EP379_RS11240	COG0723	plastoquinol--plastocyanin reductase activity
EP379_RS11250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP379_RS11260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EP379_RS11265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EP379_RS11270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EP379_RS11275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EP379_RS11290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP379_RS11295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP379_RS11300	COG1127	ABC transporter
EP379_RS11315	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EP379_RS11325	COG2853	Lipoprotein
EP379_RS11345	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EP379_RS11360	COG1137	ATPase activity
EP379_RS11370	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EP379_RS11380	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EP379_RS11385	COG1660	Displays ATPase and GTPase activities
EP379_RS11395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EP379_RS11400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EP379_RS11405	COG2239	Acts as a magnesium transporter
EP379_RS11410	COG3028	Belongs to the UPF0307 family
EP379_RS11420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP379_RS11445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EP379_RS11455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EP379_RS11465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EP379_RS11470	COG1466	dna polymerase III delta subunit
EP379_RS11485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EP379_RS11510	COG1858	cytochrome C peroxidase
EP379_RS11540	COG1278	Cold shock
EP379_RS11550	COG0714	Associated with various cellular activities
EP379_RS11580	COG0166	Belongs to the GPI family
EP379_RS11585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EP379_RS11590	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EP379_RS11595	COG0297	glycogen (starch) synthase activity
EP379_RS11600	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EP379_RS11605	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EP379_RS11610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EP379_RS11615	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EP379_RS11620	COG1428	Deoxynucleoside kinase
EP379_RS11655	COG2270	Major facilitator Superfamily
EP379_RS11705	COG1269	ATP hydrolysis coupled proton transport
EP379_RS11725	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
EP379_RS11730	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
EP379_RS11750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP379_RS11755	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EP379_RS11765	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP379_RS11765	COG0546	phosphoglycolate phosphatase activity
EP379_RS11780	COG0277	FAD linked oxidase domain protein
EP379_RS11800	COG0489	protein tyrosine kinase activity
EP379_RS11805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP379_RS11805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP379_RS11810	COG4657	Part of a membrane complex involved in electron transport
EP379_RS11815	COG2878	Part of a membrane complex involved in electron transport
EP379_RS11835	COG4659	FMN binding
EP379_RS11840	COG4660	Part of a membrane complex involved in electron transport
EP379_RS11855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EP379_RS11905	COG0346	lactoylglutathione lyase activity
EP379_RS11910	COG5002	protein histidine kinase activity
EP379_RS11910	COG5001	Diguanylate cyclase
EP379_RS11915	COG5002	protein histidine kinase activity
EP379_RS11915	COG5001	Diguanylate cyclase
EP379_RS11920	COG0137	argininosuccinate synthase activity
EP379_RS11925	COG3047	cAMP biosynthetic process
EP379_RS11925	COG2885	chlorophyll binding
EP379_RS11930	COG2133	pyrroloquinoline quinone binding
EP379_RS11945	COG1368	sulfuric ester hydrolase activity
EP379_RS11955	COG0288	reversible hydration of carbon dioxide
EP379_RS11970	COG0795	lipopolysaccharide-transporting ATPase activity
EP379_RS11975	COG0795	lipopolysaccharide-transporting ATPase activity
EP379_RS11980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EP379_RS11995	COG0525	valine-tRNA ligase activity
EP379_RS12010	COG3318	Belongs to the UPF0149 family
EP379_RS12010	COG3012	SEC-C Motif Domain Protein
EP379_RS12015	COG2183	response to ionizing radiation
EP379_RS12030	COG2992	FlgJ-related protein
EP379_RS12035	COG2095	MarC family integral membrane protein
EP379_RS12060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EP379_RS12075	COG1013	pyruvate-flavodoxin oxidoreductase activity
EP379_RS12075	COG0674	pyruvate-flavodoxin oxidoreductase activity
EP379_RS12075	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EP379_RS12075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EP379_RS12080	COG0493	'glutamate synthase
EP379_RS12105	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP379_RS12110	COG2863	cytochrome
EP379_RS12130	COG0778	Nitroreductase
EP379_RS12160	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP379_RS12160	COG0022	dehydrogenase e1 component
EP379_RS12165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EP379_RS12205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EP379_RS12215	COG0418	dihydroorotase activity
EP379_RS12225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EP379_RS12230	COG0367	asparagine synthase
EP379_RS12260	COG3706	GGDEF domain
EP379_RS12260	COG5001	Diguanylate cyclase
EP379_RS12260	COG2203	Gaf domain
EP379_RS12260	COG4251	negative regulation of phosphorylation
EP379_RS12285	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EP379_RS12290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EP379_RS12295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EP379_RS12300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EP379_RS12315	COG1136	(ABC) transporter
EP379_RS12330	COG3657	addiction module killer protein
EP379_RS12335	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EP379_RS12355	COG0581	inorganic phosphate transmembrane transporter activity
EP379_RS12360	COG0573	inorganic phosphate transmembrane transporter activity
EP379_RS12395	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EP379_RS12420	COG0745	RESPONSE REGULATOR receiver
EP379_RS12425	COG0307	riboflavin synthase, alpha
EP379_RS12435	COG0129	dihydroxy-acid dehydratase activity
EP379_RS12440	COG0189	ligase activity
EP379_RS12440	COG0569	domain protein
EP379_RS12445	COG0456	acetyltransferase
EP379_RS12445	COG1214	PFAM Peptidase M22, glycoprotease
EP379_RS12455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EP379_RS12455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EP379_RS12460	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EP379_RS12465	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EP379_RS12470	COG2199	diguanylate cyclase activity
EP379_RS12470	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EP379_RS12490	COG0494	nUDIX hydrolase
EP379_RS12500	COG5002	protein histidine kinase activity
EP379_RS12500	COG5001	Diguanylate cyclase
EP379_RS12500	COG3447	MASE1 domain protein
EP379_RS12505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP379_RS12510	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EP379_RS12535	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EP379_RS12540	COG1295	ribonuclease BN
EP379_RS12545	COG2199	diguanylate cyclase activity
EP379_RS12545	COG2200	EAL domain
EP379_RS12545	COG2202	Pas domain
EP379_RS12565	COG1643	Atp-dependent helicase
EP379_RS12580	COG1716	ATPase activity
EP379_RS12580	COG5001	Diguanylate cyclase
EP379_RS12595	COG0248	Ppx GppA phosphatase
EP379_RS12605	COG2062	phosphohistidine phosphatase, SixA
EP379_RS12615	COG3850	Histidine kinase
EP379_RS12620	COG2197	response regulator
EP379_RS12625	COG0513	Belongs to the DEAD box helicase family
EP379_RS12645	COG1917	Cupin 2, conserved barrel domain protein
EP379_RS12650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EP379_RS12655	COG0456	acetyltransferase
EP379_RS12665	COG0469	pyruvate kinase activity
EP379_RS12665	COG0469	pyruvate kinase activity
EP379_RS12675	COG0438	transferase activity, transferring glycosyl groups
EP379_RS12680	COG0438	transferase activity, transferring glycosyl groups
EP379_RS12690	COG0450	alkyl hydroperoxide reductase
EP379_RS12695	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EP379_RS12700	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EP379_RS12710	COG2197	response regulator
EP379_RS12720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EP379_RS12735	COG0488	(ABC) transporter
EP379_RS12740	COG5001	Diguanylate cyclase
EP379_RS12740	COG4251	negative regulation of phosphorylation
EP379_RS12740	COG3706	GGDEF domain
EP379_RS12740	COG2203	Gaf domain
EP379_RS12745	COG2900	Belongs to the SlyX family
EP379_RS12750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EP379_RS12750	COG0116	Belongs to the methyltransferase superfamily
EP379_RS12765	COG3012	SEC-C Motif Domain Protein
EP379_RS12775	COG1131	(ABC) transporter
EP379_RS12785	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EP379_RS12810	COG1999	signal sequence binding
EP379_RS12830	COG0012	GTP binding
EP379_RS12835	COG0193	aminoacyl-tRNA hydrolase activity
EP379_RS12840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EP379_RS12845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EP379_RS12855	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EP379_RS12860	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EP379_RS12870	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EP379_RS12875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EP379_RS12890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EP379_RS12905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EP379_RS12915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EP379_RS12920	COG0154	amidase activity
EP379_RS12925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EP379_RS12930	COG1077	Cell shape determining protein MreB Mrl
EP379_RS12935	COG1792	Involved in formation and maintenance of cell shape
EP379_RS12940	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EP379_RS12945	COG0768	penicillin binding
EP379_RS12950	COG0772	Belongs to the SEDS family
EP379_RS12955	COG2951	lytic endotransglycosylase activity
EP379_RS12965	COG1686	Belongs to the peptidase S11 family
EP379_RS12975	COG2921	Belongs to the UPF0250 family
EP379_RS12980	COG0321	lipoyl(octanoyl) transferase activity
EP379_RS12990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EP379_RS13005	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EP379_RS13010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EP379_RS13010	COG2199	diguanylate cyclase activity
EP379_RS13035	COG2801	Transposase and inactivated derivatives
EP379_RS13060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EP379_RS13075	COG3707	response regulator
EP379_RS13080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP379_RS13080	COG1116	anion transmembrane transporter activity
EP379_RS13085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP379_RS13090	COG1116	anion transmembrane transporter activity
EP379_RS13095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP379_RS13095	COG1116	anion transmembrane transporter activity
EP379_RS13100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP379_RS13105	COG2146	nitrite reductase [NAD(P)H] activity
EP379_RS13110	COG0243	molybdopterin cofactor binding
EP379_RS13115	COG1216	Glycosyl transferase, family 2
EP379_RS13115	COG0463	Glycosyl transferase, family 2
EP379_RS13120	COG2199	diguanylate cyclase activity
EP379_RS13120	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EP379_RS13155	COG2204	response regulator
EP379_RS13170	COG1294	oxidase, subunit
EP379_RS13185	COG4774	siderophore transport
EP379_RS13210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EP379_RS13230	COG3178	'Phosphotransferase
EP379_RS13235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EP379_RS13240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP379_RS13265	COG1652	LysM domain
EP379_RS13265	COG2823	Periplasmic or secreted lipoprotein
EP379_RS13280	COG0837	glucose binding
EP379_RS13285	COG2967	ApaG domain
EP379_RS13295	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EP379_RS13315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EP379_RS13325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EP379_RS13330	COG5002	protein histidine kinase activity
EP379_RS13330	COG5001	Diguanylate cyclase
EP379_RS13340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EP379_RS13345	COG0537	adenosine 5'-monophosphoramidase activity
EP379_RS13350	COG0625	glutathione transferase activity
EP379_RS13365	COG0432	Pfam Uncharacterised protein family UPF0047
EP379_RS13390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP379_RS13395	COG0577	efflux transmembrane transporter activity
EP379_RS13395	COG1136	(ABC) transporter
EP379_RS13405	COG1136	(ABC) transporter
EP379_RS13405	COG0577	efflux transmembrane transporter activity
EP379_RS13415	COG0697	spore germination
EP379_RS13455	COG3108	Peptidase M15
EP379_RS13460	COG2989	Protein conserved in bacteria
EP379_RS13475	COG0730	response to heat
EP379_RS13485	COG0714	Associated with various cellular activities
EP379_RS13525	COG2391	methyltransferase activity
EP379_RS13550	COG1233	COG1233 Phytoene dehydrogenase and related
EP379_RS13565	COG2048	Heterodisulfide reductase, subunit B
EP379_RS13570	COG2863	cytochrome
EP379_RS13575	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP379_RS13610	COG1720	tRNA m6t6A37 methyltransferase activity
EP379_RS13620	COG3123	guanosine phosphorylase activity
EP379_RS13645	COG0243	molybdopterin cofactor binding
EP379_RS13650	COG0437	4 iron, 4 sulfur cluster binding
EP379_RS13655	COG3302	dmso reductase anchor subunit
EP379_RS13675	COG3039	Transposase
EP379_RS13690	COG3668	Plasmid stabilization system
EP379_RS13705	COG2046	Belongs to the sulfate adenylyltransferase family
EP379_RS13710	COG2703	oxygen carrier activity
EP379_RS13720	COG3043	anaerobic respiration
EP379_RS13725	COG0348	domain, Protein
EP379_RS13730	COG0437	4 iron, 4 sulfur cluster binding
EP379_RS13735	COG0243	molybdopterin cofactor binding
EP379_RS13745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EP379_RS13745	COG2221	Nitrite and sulphite reductase 4Fe-4S
EP379_RS13750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EP379_RS13765	COG3746	phosphate-selective porin O and P
EP379_RS13800	COG0730	response to heat
EP379_RS13805	COG1012	belongs to the aldehyde dehydrogenase family
EP379_RS13815	COG0617	tRNA 3'-terminal CCA addition
EP379_RS13820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP379_RS13825	COG1968	undecaprenyl-diphosphatase activity
EP379_RS13850	COG3852	Histidine kinase
EP379_RS13855	COG4566	intracellular signal transduction
EP379_RS13855	COG0745	RESPONSE REGULATOR receiver
EP379_RS13870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EP379_RS13875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EP379_RS13880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EP379_RS13885	COG1610	YqeY-like protein
EP379_RS13890	COG0358	DNA primase activity
EP379_RS13925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP379_RS13930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EP379_RS13935	COG0140	phosphoribosyl-ATP diphosphatase activity
EP379_RS13940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EP379_RS13945	COG0107	imidazoleglycerol-phosphate synthase activity
EP379_RS13950	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EP379_RS13955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EP379_RS13960	COG0131	Imidazoleglycerol-phosphate dehydratase
EP379_RS13965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP379_RS13970	COG3278	Belongs to the heme-copper respiratory oxidase family
EP379_RS13985	COG2010	Cytochrome c
EP379_RS13990	COG0348	domain, Protein
EP379_RS14000	COG2217	Heavy metal translocating P-type atpase
EP379_RS14020	COG1490	D-aminoacyl-tRNA deacylase activity
EP379_RS14030	COG1217	gtp-binding protein TYPA
EP379_RS14060	COG1136	(ABC) transporter
EP379_RS14060	COG0577	efflux transmembrane transporter activity
EP379_RS14120	COG0724	RNA recognition motif
EP379_RS14125	COG3228	Belongs to the MtfA family
EP379_RS14130	COG0864	Transcriptional regulator
EP379_RS14135	COG1122	ATPase activity
EP379_RS14165	COG1252	NADH dehydrogenase
EP379_RS14170	COG1215	transferase activity, transferring glycosyl groups
EP379_RS14175	COG0564	pseudouridine synthase activity
EP379_RS14190	COG0058	SHG alpha-glucan phosphorylase activity
EP379_RS14195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EP379_RS14235	COG0281	malic enzyme
EP379_RS14240	COG0254	rRNA binding
EP379_RS14245	COG0058	SHG alpha-glucan phosphorylase activity
EP379_RS14250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EP379_RS14260	COG0513	Belongs to the DEAD box helicase family
EP379_RS14285	COG1011	Hydrolase
EP379_RS14290	COG0494	nUDIX hydrolase
EP379_RS14305	COG0488	(ABC) transporter
EP379_RS14355	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EP379_RS14365	COG1575	Belongs to the MenA family. Type 1 subfamily
EP379_RS14425	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EP379_RS14440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EP379_RS14640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EP379_RS14810	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EP379_RS14870	COG1061	Type III restriction enzyme res subunit
EP379_RS14940	COG0640	Transcriptional regulator
EP379_RS14975	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EP379_RS14980	COG1194	a g-specific adenine glycosylase
EP379_RS15005	COG1022	Amp-dependent synthetase and ligase
EP379_RS15015	COG2022	thiamine diphosphate biosynthetic process
EP379_RS15020	COG0598	Magnesium transport protein CorA
EP379_RS15025	COG3264	Mechanosensitive ion channel
EP379_RS15025	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EP379_RS15030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EP379_RS15055	COG0204	Acyl-transferase
EP379_RS15055	COG0318	PFAM AMP-dependent synthetase and ligase
EP379_RS15090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EP379_RS15110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP379_RS15130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EP379_RS15135	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EP379_RS15140	COG0631	protein serine/threonine phosphatase activity
EP379_RS15150	COG1561	YicC-like family, N-terminal region
EP379_RS15170	COG1758	RNA polymerase activity
EP379_RS15175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP379_RS15185	COG0577	efflux transmembrane transporter activity
EP379_RS15185	COG1136	(ABC) transporter
EP379_RS15190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP379_RS15205	COG4256	Hemin uptake protein
EP379_RS15235	COG2095	MarC family integral membrane protein
EP379_RS15250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP379_RS15255	COG0500	methyltransferase
EP379_RS15275	COG0415	Belongs to the DNA photolyase family
EP379_RS15280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EP379_RS15285	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EP379_RS15290	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EP379_RS15310	COG1444	tRNA N-acetyltransferase activity
EP379_RS15315	COG0583	DNA-binding transcription factor activity
EP379_RS15320	COG1741	Belongs to the pirin family
EP379_RS15325	COG3038	cytochrome b561
EP379_RS15330	COG2353	YceI-like domain
EP379_RS15360	COG1136	(ABC) transporter
EP379_RS15360	COG0577	efflux transmembrane transporter activity
EP379_RS15400	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
EP379_RS15415	COG5002	protein histidine kinase activity
EP379_RS15420	COG0745	RESPONSE REGULATOR receiver
EP379_RS15450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP379_RS15455	COG1773	rubredoxin
EP379_RS15465	COG0583	DNA-binding transcription factor activity
EP379_RS15470	COG0450	alkyl hydroperoxide reductase
EP379_RS15475	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EP379_RS15485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EP379_RS15510	COG4181	ATPase activity
EP379_RS15515	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EP379_RS15530	COG0583	DNA-binding transcription factor activity
EP379_RS15540	COG3258	Cytochrome c
EP379_RS15550	COG0563	adenylate kinase activity
EP379_RS15555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EP379_RS15565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EP379_RS15590	COG2944	sequence-specific DNA binding
EP379_RS15615	COG0469	pyruvate kinase activity
EP379_RS15620	COG0126	phosphoglycerate kinase activity
EP379_RS15625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EP379_RS15630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EP379_RS15640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EP379_RS15645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EP379_RS15650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EP379_RS15655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EP379_RS15670	COG2198	Histidine kinase
EP379_RS15670	COG0784	Response regulator, receiver
EP379_RS15670	COG0643	Histidine kinase
EP379_RS15675	COG0840	transmembrane signaling receptor activity
EP379_RS15720	COG3065	identical protein binding
EP379_RS15730	COG3245	cytochrome
EP379_RS15755	COG2514	catechol 2,3-dioxygenase activity
EP379_RS15770	COG0727	PFAM Uncharacterised protein family (UPF0153)
EP379_RS15805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP379_RS15830	COG0028	Belongs to the TPP enzyme family
EP379_RS15835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP379_RS15845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EP379_RS15850	COG1333	cytochrome c biogenesis protein
EP379_RS15850	COG1333	cytochrome c biogenesis protein
EP379_RS15860	COG3245	cytochrome
EP379_RS15865	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EP379_RS15890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EP379_RS15895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP379_RS15900	COG3098	single-species biofilm formation
EP379_RS15905	COG3039	Transposase
EP379_RS15915	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EP379_RS15920	COG0210	DNA helicase
EP379_RS15930	COG0408	coproporphyrinogen oxidase activity
EP379_RS15935	COG0009	L-threonylcarbamoyladenylate synthase
EP379_RS15940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EP379_RS15950	COG2922	Belongs to the Smg family
EP379_RS15955	COG0758	DNA mediated transformation
EP379_RS15965	COG0242	peptide deformylase activity
EP379_RS15970	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EP379_RS15985	COG5000	phosphorelay sensor kinase activity
EP379_RS15990	COG2204	response regulator
EP379_RS15995	COG0569	domain protein
EP379_RS16020	COG2738	Putative neutral zinc metallopeptidase
EP379_RS16035	COG4681	YaeQ
EP379_RS16040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP379_RS16070	COG1280	lysine exporter protein (LysE YggA)
EP379_RS16110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP379_RS16115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EP379_RS16125	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EP379_RS16130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EP379_RS16135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EP379_RS16140	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EP379_RS16145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EP379_RS16150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EP379_RS16160	COG0356	it plays a direct role in the translocation of protons across the membrane
EP379_RS16170	COG1475	DNA binding
EP379_RS16175	COG1192	Involved in chromosome partitioning
EP379_RS16180	COG0357	Ribosomal RNA small subunit methyltransferase G
EP379_RS16190	COG0445	tRNA wobble uridine modification
EP379_RS16230	COG3954	Phosphoribulokinase
EP379_RS16245	COG0714	Associated with various cellular activities
EP379_RS16260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EP379_RS16265	COG0706	membrane insertase activity
EP379_RS16270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EP379_RS16275	COG0594	ribonuclease P activity