locus-tag	class	description
SHALO_RS00010	COG0592	DNA-directed DNA polymerase activity
SHALO_RS00015	COG0187	DNA topoisomerase II activity
SHALO_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SHALO_RS00040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SHALO_RS00045	COG1194	a g-specific adenine glycosylase
SHALO_RS00050	COG4175	Glycine betaine
SHALO_RS00055	COG4176	ABC-type proline glycine betaine transport system permease component
SHALO_RS00060	COG2113	Glycine betaine
SHALO_RS00065	COG2814	Major facilitator Superfamily
SHALO_RS00075	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SHALO_RS00085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SHALO_RS00090	COG0066	3-isopropylmalate dehydratase activity
SHALO_RS00120	COG3706	GGDEF domain
SHALO_RS00130	COG0840	transmembrane signaling receptor activity
SHALO_RS00155	COG0745	RESPONSE REGULATOR receiver
SHALO_RS00165	COG0840	transmembrane signaling receptor activity
SHALO_RS00170	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SHALO_RS00185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHALO_RS00190	COG1335	isochorismatase
SHALO_RS00205	COG2207	Transcriptional regulator
SHALO_RS00205	COG3708	Transcriptional regulator
SHALO_RS00220	COG1355	regulation of microtubule-based process
SHALO_RS00240	COG1609	Transcriptional regulator
SHALO_RS00240	COG2207	Transcriptional regulator
SHALO_RS00250	COG3150	esterase
SHALO_RS00255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SHALO_RS00265	COG3383	formate dehydrogenase (NAD+) activity
SHALO_RS00270	COG4974	Belongs to the 'phage' integrase family
SHALO_RS00310	COG0653	protein targeting
SHALO_RS00320	COG2184	nucleotidyltransferase activity
SHALO_RS00410	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
SHALO_RS00435	COG0129	dihydroxy-acid dehydratase activity
SHALO_RS00440	COG2095	MarC family integral membrane protein
SHALO_RS00470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHALO_RS00475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SHALO_RS00480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SHALO_RS00495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SHALO_RS00495	COG1328	CTP reductase activity
SHALO_RS00500	COG1794	racemase activity, acting on amino acids and derivatives
SHALO_RS00505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SHALO_RS00510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SHALO_RS00515	COG0564	pseudouridine synthase activity
SHALO_RS00520	COG0179	Fumarylacetoacetate (FAA) hydrolase
SHALO_RS00525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SHALO_RS00535	COG0107	imidazoleglycerol-phosphate synthase activity
SHALO_RS00545	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SHALO_RS00550	COG0517	IMP dehydrogenase activity
SHALO_RS00550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SHALO_RS00555	COG1187	pseudouridine synthase activity
SHALO_RS00560	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SHALO_RS00560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SHALO_RS00570	COG2257	FlhB HrpN YscU SpaS Family
SHALO_RS00580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SHALO_RS00585	COG0237	dephospho-CoA kinase activity
SHALO_RS00590	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SHALO_RS00600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SHALO_RS00605	COG0268	Binds directly to 16S ribosomal RNA
SHALO_RS00620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SHALO_RS00625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SHALO_RS00635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SHALO_RS00640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SHALO_RS00645	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SHALO_RS00650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SHALO_RS00655	COG0348	domain, Protein
SHALO_RS00665	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SHALO_RS00680	COG0754	glutathionylspermidine amidase activity
SHALO_RS00695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SHALO_RS00725	COG0642	Histidine kinase
SHALO_RS00730	COG0745	RESPONSE REGULATOR receiver
SHALO_RS00745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SHALO_RS00750	COG1127	ABC transporter
SHALO_RS00755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SHALO_RS00765	COG2095	MarC family integral membrane protein
SHALO_RS00770	COG0840	transmembrane signaling receptor activity
SHALO_RS00780	COG0784	Response regulator, receiver
SHALO_RS00780	COG3437	response regulator, receiver
SHALO_RS00805	COG0745	RESPONSE REGULATOR receiver
SHALO_RS00810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SHALO_RS00820	COG0004	ammonium transporteR
SHALO_RS00825	COG0667	Aldo Keto reductase
SHALO_RS00835	COG0745	RESPONSE REGULATOR receiver
SHALO_RS00850	COG0765	amino acid transport
SHALO_RS00880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SHALO_RS00885	COG1121	(ABC) transporter
SHALO_RS00905	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SHALO_RS00915	COG0318	PFAM AMP-dependent synthetase and ligase
SHALO_RS00920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SHALO_RS00925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS00930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS00935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS00940	COG0649	NAD binding
SHALO_RS00960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SHALO_RS00965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS00970	COG0839	Belongs to the complex I subunit 6 family
SHALO_RS00975	COG0713	ATP synthesis coupled electron transport
SHALO_RS00980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SHALO_RS00985	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS00990	COG1007	ATP synthesis coupled electron transport
SHALO_RS01000	COG1012	belongs to the aldehyde dehydrogenase family
SHALO_RS01005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SHALO_RS01025	COG0840	transmembrane signaling receptor activity
SHALO_RS01035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SHALO_RS01040	COG1546	Belongs to the CinA family
SHALO_RS01040	COG1058	Belongs to the CinA family
SHALO_RS01050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SHALO_RS01055	COG0254	rRNA binding
SHALO_RS01060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SHALO_RS01080	COG0436	Aminotransferase
SHALO_RS01085	COG0460	homoserine dehydrogenase
SHALO_RS01090	COG0792	nuclease activity
SHALO_RS01095	COG3118	belongs to the thioredoxin family
SHALO_RS01100	COG0492	ferredoxin-NADP+ reductase activity
SHALO_RS01105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SHALO_RS01110	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SHALO_RS01115	COG1242	4 iron, 4 sulfur cluster binding
SHALO_RS01130	COG0140	phosphoribosyl-ATP diphosphatase activity
SHALO_RS01130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SHALO_RS01145	COG1012	belongs to the aldehyde dehydrogenase family
SHALO_RS01150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SHALO_RS01160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SHALO_RS01165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SHALO_RS01170	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SHALO_RS01175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SHALO_RS01190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SHALO_RS01220	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SHALO_RS01225	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SHALO_RS01230	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SHALO_RS01235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SHALO_RS01240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SHALO_RS01250	COG0784	Response regulator, receiver
SHALO_RS01250	COG0835	chemotaxis
SHALO_RS01255	COG0784	Response regulator, receiver
SHALO_RS01255	COG2198	Histidine kinase
SHALO_RS01255	COG0643	Histidine kinase
SHALO_RS01260	COG0835	chemotaxis
SHALO_RS01270	COG0560	Phosphoserine phosphatase
SHALO_RS01275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SHALO_RS01290	COG0193	aminoacyl-tRNA hydrolase activity
SHALO_RS01300	COG0019	diaminopimelate decarboxylase activity
SHALO_RS01305	COG1605	Chorismate mutase
SHALO_RS01305	COG0077	Prephenate dehydratase
SHALO_RS01310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SHALO_RS01320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SHALO_RS01345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SHALO_RS01355	COG0450	alkyl hydroperoxide reductase
SHALO_RS01360	COG0840	transmembrane signaling receptor activity
SHALO_RS01370	COG0105	UTP biosynthetic process
SHALO_RS01380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SHALO_RS01385	COG0416	fatty acid biosynthetic process
SHALO_RS01390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHALO_RS01395	COG0287	Prephenate dehydrogenase
SHALO_RS01400	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHALO_RS01405	COG0248	Ppx GppA phosphatase
SHALO_RS01410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SHALO_RS01420	COG0745	RESPONSE REGULATOR receiver
SHALO_RS01430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SHALO_RS01440	COG0157	Belongs to the NadC ModD family
SHALO_RS01445	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SHALO_RS01460	COG0850	regulation of cytokinetic process
SHALO_RS01465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SHALO_RS01475	COG0083	homoserine kinase activity
SHALO_RS01485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SHALO_RS01495	COG0779	Required for maturation of 30S ribosomal subunits
SHALO_RS01500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SHALO_RS01500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SHALO_RS01510	COG5001	Diguanylate cyclase
SHALO_RS01520	COG5002	protein histidine kinase activity
SHALO_RS01535	COG3258	Cytochrome c
SHALO_RS01555	COG0243	molybdopterin cofactor binding
SHALO_RS01560	COG0437	4 iron, 4 sulfur cluster binding
SHALO_RS01565	COG3301	Polysulphide reductase, NrfD
SHALO_RS01570	COG3287	FIST C domain
SHALO_RS01570	COG2200	EAL domain
SHALO_RS01570	COG2199	diguanylate cyclase activity
SHALO_RS01580	COG0437	4 iron, 4 sulfur cluster binding
SHALO_RS01585	COG3301	Polysulphide reductase, NrfD
SHALO_RS01590	COG0745	RESPONSE REGULATOR receiver
SHALO_RS01595	COG5002	protein histidine kinase activity
SHALO_RS01605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SHALO_RS01615	COG1227	inorganic diphosphatase activity
SHALO_RS01635	COG1570	exodeoxyribonuclease VII activity
SHALO_RS01645	COG3706	GGDEF domain
SHALO_RS01655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SHALO_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
SHALO_RS01665	COG2207	Transcriptional regulator
SHALO_RS01670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHALO_RS01675	COG0583	DNA-binding transcription factor activity
SHALO_RS01680	COG2855	membrane
SHALO_RS01685	COG0386	Belongs to the glutathione peroxidase family
SHALO_RS01700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SHALO_RS01720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHALO_RS01755	COG1136	(ABC) transporter
SHALO_RS01755	COG0577	efflux transmembrane transporter activity
SHALO_RS01780	COG0348	domain, Protein
SHALO_RS01795	COG0437	4 iron, 4 sulfur cluster binding
SHALO_RS01810	COG4263	nitrous-oxide reductase activity
SHALO_RS01815	COG3852	Histidine kinase
SHALO_RS01820	COG2207	Transcriptional regulator
SHALO_RS01820	COG4753	response regulator
SHALO_RS01825	COG2863	cytochrome
SHALO_RS01870	COG0386	Belongs to the glutathione peroxidase family
SHALO_RS01890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SHALO_RS01895	COG1994	Peptidase M50
SHALO_RS01900	COG0402	S-adenosylhomocysteine deaminase activity
SHALO_RS01905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SHALO_RS01910	COG0006	proline dipeptidase activity
SHALO_RS01915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SHALO_RS01920	COG1419	protein localization to endoplasmic reticulum
SHALO_RS01925	COG0455	bacterial-type flagellum organization
SHALO_RS01935	COG1191	sigma factor activity
SHALO_RS01940	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SHALO_RS01945	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SHALO_RS01945	COG1776	CheC inhibitor of MCP methylation
SHALO_RS01950	COG1611	Belongs to the LOG family
SHALO_RS01960	COG0463	Glycosyl transferase, family 2
SHALO_RS01970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SHALO_RS01975	COG2076	Multidrug Resistance protein
SHALO_RS01990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SHALO_RS02000	COG1040	competence protein
SHALO_RS02030	COG2204	response regulator
SHALO_RS02035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SHALO_RS02045	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SHALO_RS02050	COG0731	radical SAM domain protein
SHALO_RS02060	COG2358	TRAP transporter, solute receptor (TAXI family
SHALO_RS02070	COG0582	viral genome integration into host DNA
SHALO_RS02075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SHALO_RS02135	COG2274	protein secretion by the type I secretion system
SHALO_RS02185	COG0419	ATPase involved in DNA repair
SHALO_RS02205	COG0039	L-malate dehydrogenase activity
SHALO_RS02215	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SHALO_RS02235	COG0693	protein deglycase activity
SHALO_RS02265	COG3287	FIST C domain
SHALO_RS02265	COG2200	EAL domain
SHALO_RS02265	COG2199	diguanylate cyclase activity
SHALO_RS02280	COG3118	belongs to the thioredoxin family
SHALO_RS02290	COG4336	lyase activity
SHALO_RS02315	COG4628	conserved protein (DUF2132)
SHALO_RS02320	COG4221	oxidoreductase activity
SHALO_RS02335	COG0683	leucine binding
SHALO_RS02360	COG1012	belongs to the aldehyde dehydrogenase family
SHALO_RS02370	COG3022	response to hydroperoxide
SHALO_RS02395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SHALO_RS02400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SHALO_RS02410	COG0250	Participates in transcription elongation, termination and antitermination
SHALO_RS02415	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SHALO_RS02420	COG0081	regulation of translation
SHALO_RS02425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SHALO_RS02430	COG0222	ribosome binding
SHALO_RS02435	COG0085	RNA polymerase activity
SHALO_RS02440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SHALO_RS02445	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SHALO_RS02455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SHALO_RS02465	COG2011	ABC-type metal ion transport system permease component
SHALO_RS02470	COG1464	Belongs to the NlpA lipoprotein family
SHALO_RS02480	COG1522	sequence-specific DNA binding
SHALO_RS02485	COG0697	spore germination
SHALO_RS02500	COG0534	Mate efflux family protein
SHALO_RS02515	COG0745	RESPONSE REGULATOR receiver
SHALO_RS02530	COG0840	transmembrane signaling receptor activity
SHALO_RS02535	COG0840	transmembrane signaling receptor activity
SHALO_RS02545	COG1034	ATP synthesis coupled electron transport
SHALO_RS02550	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SHALO_RS02555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS02565	COG0713	ATP synthesis coupled electron transport
SHALO_RS02570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SHALO_RS02575	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS02580	COG1007	ATP synthesis coupled electron transport
SHALO_RS02600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS02600	COG0649	NAD binding
SHALO_RS02605	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS02610	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS02625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SHALO_RS02645	COG0357	Ribosomal RNA small subunit methyltransferase G
SHALO_RS02650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SHALO_RS02655	COG1970	mechanosensitive ion channel activity
SHALO_RS02665	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHALO_RS02670	COG0113	porphobilinogen synthase activity
SHALO_RS02675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SHALO_RS02685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SHALO_RS02690	COG0247	lactate metabolic process
SHALO_RS02715	COG2026	Addiction module toxin, RelE StbE family
SHALO_RS02720	COG3706	GGDEF domain
SHALO_RS02730	COG3012	SEC-C Motif Domain Protein
SHALO_RS02745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SHALO_RS02755	COG1053	succinate dehydrogenase
SHALO_RS02760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SHALO_RS02770	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SHALO_RS02780	COG0628	permease
SHALO_RS02785	COG2255	four-way junction helicase activity
SHALO_RS02790	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SHALO_RS02800	COG0159	tryptophan synthase activity
SHALO_RS02820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SHALO_RS02825	COG1136	(ABC) transporter
SHALO_RS02830	COG1684	flagellar biosynthetic protein fliR
SHALO_RS02840	COG0194	GDP metabolic process
SHALO_RS02845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SHALO_RS02850	COG0018	arginyl-trna synthetase
SHALO_RS02860	COG2199	diguanylate cyclase activity
SHALO_RS02860	COG2200	EAL domain
SHALO_RS02860	COG3287	FIST C domain
SHALO_RS02875	COG0735	belongs to the Fur family
SHALO_RS02885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SHALO_RS02890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SHALO_RS02900	COG0149	triose-phosphate isomerase activity
SHALO_RS02905	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SHALO_RS02915	COG0195	Participates in both transcription termination and antitermination
SHALO_RS02950	COG0037	tRNA processing
SHALO_RS02955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SHALO_RS02960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SHALO_RS02965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SHALO_RS02990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SHALO_RS02995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SHALO_RS03000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SHALO_RS03010	COG1151	hydroxylamine reductase activity
SHALO_RS03035	COG2326	polyphosphate kinase activity
SHALO_RS03050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SHALO_RS03065	COG0513	Belongs to the DEAD box helicase family
SHALO_RS03070	COG2610	gluconate transmembrane transporter activity
SHALO_RS03075	COG1944	ATP diphosphatase activity
SHALO_RS03085	COG1538	Outer membrane efflux protein
SHALO_RS03095	COG2814	Major facilitator Superfamily
SHALO_RS03100	COG0589	response to stress
SHALO_RS03130	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SHALO_RS03145	COG2361	Protein of unknown function DUF86
SHALO_RS03210	COG0559	Belongs to the binding-protein-dependent transport system permease family
SHALO_RS03230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SHALO_RS03230	COG1333	cytochrome c biogenesis protein
SHALO_RS03270	COG1546	Belongs to the CinA family
SHALO_RS03270	COG1058	Belongs to the CinA family
SHALO_RS03275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SHALO_RS03285	COG0517	IMP dehydrogenase activity
SHALO_RS03285	COG0516	GMP reductase activity
SHALO_RS03290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SHALO_RS03305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SHALO_RS03310	COG0436	Aminotransferase
SHALO_RS03325	COG1193	negative regulation of DNA recombination
SHALO_RS03330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SHALO_RS03335	COG0251	oxidation-reduction process
SHALO_RS03340	COG0579	oxidoreductase
SHALO_RS03355	COG0454	-acetyltransferase
SHALO_RS03355	COG0456	acetyltransferase
SHALO_RS03360	COG0793	Belongs to the peptidase S41A family
SHALO_RS03375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SHALO_RS03380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SHALO_RS03385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SHALO_RS03390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SHALO_RS03395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SHALO_RS03405	COG1192	Involved in chromosome partitioning
SHALO_RS03410	COG1475	DNA binding
SHALO_RS03420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SHALO_RS03425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SHALO_RS03435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SHALO_RS03450	COG0811	peptide transport
SHALO_RS03455	COG0848	biopolymer transport protein
SHALO_RS03465	COG0823	Involved in the tonB-independent uptake of proteins
SHALO_RS03480	COG1047	Peptidyl-prolyl cis-trans
SHALO_RS03490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SHALO_RS03495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SHALO_RS03500	COG0037	tRNA processing
SHALO_RS03510	COG0067	glutamate synthase
SHALO_RS03510	COG0070	glutamate synthase
SHALO_RS03510	COG0069	glutamate synthase activity
SHALO_RS03515	COG0493	'glutamate synthase
SHALO_RS03525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SHALO_RS03530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SHALO_RS03535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SHALO_RS03545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SHALO_RS03565	COG1776	CheC inhibitor of MCP methylation
SHALO_RS03565	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SHALO_RS03580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SHALO_RS03590	COG0748	coenzyme F420 binding
SHALO_RS03600	COG0454	-acetyltransferase
SHALO_RS03610	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SHALO_RS03620	COG1113	amino acid transport
SHALO_RS03625	COG0730	response to heat
SHALO_RS03630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SHALO_RS03635	COG1301	dicarboxylic acid transport
SHALO_RS03640	COG1301	dicarboxylic acid transport
SHALO_RS03650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SHALO_RS03650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SHALO_RS03655	COG1971	Probably functions as a manganese efflux pump
SHALO_RS03665	COG0484	heat shock protein binding
SHALO_RS03690	COG1271	oxidase subunit
SHALO_RS03695	COG1294	oxidase, subunit
SHALO_RS03700	COG0745	RESPONSE REGULATOR receiver
SHALO_RS03705	COG0642	Histidine kinase
SHALO_RS03710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SHALO_RS03725	COG0318	PFAM AMP-dependent synthetase and ligase
SHALO_RS03730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SHALO_RS03735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SHALO_RS03750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SHALO_RS03755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SHALO_RS03770	COG3706	GGDEF domain
SHALO_RS03780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SHALO_RS03815	COG2205	protein histidine kinase activity
SHALO_RS03815	COG0784	Response regulator, receiver
SHALO_RS03815	COG5002	protein histidine kinase activity
SHALO_RS03830	COG0322	excinuclease ABC activity
SHALO_RS03840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SHALO_RS03845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SHALO_RS03850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SHALO_RS03850	COG0519	Catalyzes the synthesis of GMP from XMP
SHALO_RS03880	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SHALO_RS03970	COG0745	RESPONSE REGULATOR receiver
SHALO_RS03995	COG0511	ligase activity, forming carbon-carbon bonds
SHALO_RS04005	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SHALO_RS04010	COG0165	Argininosuccinate lyase
SHALO_RS04015	COG0537	adenosine 5'-monophosphoramidase activity
SHALO_RS04020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SHALO_RS04025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHALO_RS04025	COG0072	phenylalanine-tRNA ligase activity
SHALO_RS04030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SHALO_RS04035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SHALO_RS04040	COG1185	polyribonucleotide nucleotidyltransferase activity
SHALO_RS04040	COG0539	negative regulation of cytoplasmic translation
SHALO_RS04050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SHALO_RS04060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SHALO_RS04070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SHALO_RS04080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SHALO_RS04085	COG0693	protein deglycase activity
SHALO_RS04095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SHALO_RS04110	COG2081	HI0933 family
SHALO_RS04150	COG2199	diguanylate cyclase activity
SHALO_RS04150	COG3287	FIST C domain
SHALO_RS04150	COG2200	EAL domain
SHALO_RS04175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SHALO_RS04180	COG0840	transmembrane signaling receptor activity
SHALO_RS04185	COG0840	transmembrane signaling receptor activity
SHALO_RS04185	COG0840	transmembrane signaling receptor activity
SHALO_RS04195	COG0587	DNA-directed DNA polymerase activity
SHALO_RS04205	COG0642	Histidine kinase
SHALO_RS04215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SHALO_RS04220	COG0569	domain protein
SHALO_RS04235	COG0772	Belongs to the SEDS family
SHALO_RS04240	COG0564	pseudouridine synthase activity
SHALO_RS04250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SHALO_RS04270	COG0528	UMP kinase activity
SHALO_RS04275	COG1758	RNA polymerase activity
SHALO_RS04285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SHALO_RS04295	COG0860	N-Acetylmuramoyl-L-alanine amidase
SHALO_RS04305	COG0563	adenylate kinase activity
SHALO_RS04310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SHALO_RS04325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SHALO_RS04330	COG0497	DNA recombination
SHALO_RS04335	COG1620	l-lactate permease
SHALO_RS04340	COG3706	GGDEF domain
SHALO_RS04345	COG0084	hydrolase, TatD family'
SHALO_RS04350	COG3942	CHAP domain
SHALO_RS04350	COG1388	LysM domain
SHALO_RS04355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SHALO_RS04360	COG0131	Imidazoleglycerol-phosphate dehydratase
SHALO_RS04365	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SHALO_RS04380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SHALO_RS04395	COG0768	penicillin binding
SHALO_RS04415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHALO_RS04415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHALO_RS04425	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SHALO_RS04450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SHALO_RS04455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SHALO_RS04470	COG2197	response regulator
SHALO_RS04475	COG0471	metal ion transport
SHALO_RS04485	COG0840	transmembrane signaling receptor activity
SHALO_RS04495	COG3279	Response regulator of the LytR AlgR family
SHALO_RS04500	COG3920	Histidine kinase
SHALO_RS04510	COG0583	DNA-binding transcription factor activity
SHALO_RS04515	COG1053	succinate dehydrogenase
SHALO_RS04520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SHALO_RS04525	COG2048	Heterodisulfide reductase, subunit B
SHALO_RS04535	COG0840	transmembrane signaling receptor activity
SHALO_RS04550	COG3005	denitrification pathway
SHALO_RS04555	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SHALO_RS04560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SHALO_RS04560	COG1333	cytochrome c biogenesis protein
SHALO_RS04580	COG3545	Serine hydrolase
SHALO_RS04585	COG0642	Histidine kinase
SHALO_RS04610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SHALO_RS04615	COG1346	cytolysis
SHALO_RS04635	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
SHALO_RS04645	COG0398	Pfam SNARE associated Golgi protein
SHALO_RS04655	COG0398	Pfam SNARE associated Golgi protein
SHALO_RS04660	COG2226	methyltransferase
SHALO_RS04665	COG0697	spore germination
SHALO_RS04675	COG2207	Transcriptional regulator
SHALO_RS04710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SHALO_RS04725	COG0109	protoheme IX farnesyltransferase activity
SHALO_RS04730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SHALO_RS04745	COG1845	cytochrome c oxidase, subunit III
SHALO_RS04745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SHALO_RS04770	COG0243	molybdopterin cofactor binding
SHALO_RS04775	COG0437	4 iron, 4 sulfur cluster binding
SHALO_RS04780	COG0348	domain, Protein
SHALO_RS04785	COG3043	anaerobic respiration
SHALO_RS04790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SHALO_RS04790	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
SHALO_RS04805	COG0840	transmembrane signaling receptor activity
SHALO_RS04840	COG1595	DNA-templated transcription, initiation
SHALO_RS04855	COG0243	molybdopterin cofactor binding
SHALO_RS04870	COG0745	RESPONSE REGULATOR receiver
SHALO_RS04885	COG2863	cytochrome
SHALO_RS04890	COG0723	plastoquinol--plastocyanin reductase activity
SHALO_RS04895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SHALO_RS04915	COG2199	diguanylate cyclase activity
SHALO_RS04915	COG2200	EAL domain
SHALO_RS04915	COG3287	FIST C domain
SHALO_RS04920	COG0688	phosphatidylethanolamine metabolic process
SHALO_RS04925	COG0513	Belongs to the DEAD box helicase family
SHALO_RS04935	COG2964	Protein conserved in bacteria
SHALO_RS04940	COG2084	Dehydrogenase
SHALO_RS04950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHALO_RS04960	COG1280	lysine exporter protein (LysE YggA)
SHALO_RS04965	COG3437	response regulator, receiver
SHALO_RS04965	COG0784	Response regulator, receiver
SHALO_RS04985	COG4585	Histidine kinase
SHALO_RS04995	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SHALO_RS05000	COG2249	NAD(P)H dehydrogenase (quinone) activity
SHALO_RS05010	COG0217	transcriptional regulatory protein
SHALO_RS05020	COG2358	TRAP transporter, solute receptor (TAXI family
SHALO_RS05035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SHALO_RS05060	COG4974	Belongs to the 'phage' integrase family
SHALO_RS05110	COG0542	response to heat
SHALO_RS05205	COG3045	CreA protein
SHALO_RS05220	COG2207	Transcriptional regulator
SHALO_RS05220	COG4753	response regulator
SHALO_RS05250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SHALO_RS05255	COG2197	response regulator
SHALO_RS05280	COG1305	Transglutaminase-like
SHALO_RS05290	COG3093	addiction module antidote protein HigA
SHALO_RS05310	COG1305	Transglutaminase-like
SHALO_RS05320	COG2308	Evidence 4 Homologs of previously reported genes of
SHALO_RS05335	COG2966	Psort location CytoplasmicMembrane, score
SHALO_RS05340	COG3610	response to peptide
SHALO_RS05345	COG2703	oxygen carrier activity
SHALO_RS05350	COG2217	Heavy metal translocating P-type atpase
SHALO_RS05370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SHALO_RS05385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHALO_RS05395	COG0840	transmembrane signaling receptor activity
SHALO_RS05395	COG3290	protein histidine kinase activity
SHALO_RS05405	COG0352	thiamine-phosphate diphosphorylase activity
SHALO_RS05420	COG1272	protein, Hemolysin III
SHALO_RS05435	COG0247	lactate metabolic process
SHALO_RS05440	COG1139	Iron-sulfur cluster binding protein
SHALO_RS05445	COG1556	Lactate utilization protein
SHALO_RS05450	COG0697	spore germination
SHALO_RS05470	COG2176	DNA-directed DNA polymerase activity
SHALO_RS05480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SHALO_RS05490	COG0501	Belongs to the peptidase M48B family
SHALO_RS05510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SHALO_RS05515	COG2201	protein-glutamate methylesterase activity
SHALO_RS05520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SHALO_RS05525	COG0586	Pfam SNARE associated Golgi protein
SHALO_RS05530	COG0133	tryptophan synthase activity
SHALO_RS05535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SHALO_RS05545	COG0698	ribose 5-phosphate isomerase
SHALO_RS05550	COG1994	Peptidase M50
SHALO_RS05555	COG0681	Belongs to the peptidase S26 family
SHALO_RS05560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SHALO_RS05570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SHALO_RS05585	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SHALO_RS05590	COG0612	Peptidase, M16
SHALO_RS05595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SHALO_RS05625	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SHALO_RS05630	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHALO_RS05635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SHALO_RS05640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SHALO_RS05645	COG0629	single-stranded DNA binding
SHALO_RS05650	COG0360	Binds together with S18 to 16S ribosomal RNA
SHALO_RS05655	COG1466	dna polymerase III delta subunit
SHALO_RS05660	COG0557	exoribonuclease II activity
SHALO_RS05670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SHALO_RS05675	COG2894	cell division
SHALO_RS05680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SHALO_RS05695	COG0730	response to heat
SHALO_RS05700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SHALO_RS05715	COG1760	l-serine dehydratase
SHALO_RS05720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SHALO_RS05725	COG2860	membrane
SHALO_RS05730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SHALO_RS05745	COG0736	holo-[acyl-carrier-protein] synthase activity
SHALO_RS05750	COG1580	Controls the rotational direction of flagella during chemotaxis
SHALO_RS05755	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SHALO_RS05760	COG0552	protein localization to endoplasmic reticulum
SHALO_RS05765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SHALO_RS05775	COG1418	mRNA catabolic process
SHALO_RS05780	COG1132	(ABC) transporter
SHALO_RS05790	COG0586	Pfam SNARE associated Golgi protein
SHALO_RS05805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SHALO_RS05815	COG4753	response regulator
SHALO_RS05815	COG2207	Transcriptional regulator
SHALO_RS05825	COG5002	protein histidine kinase activity
SHALO_RS05825	COG5001	Diguanylate cyclase
SHALO_RS05845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SHALO_RS05920	COG5002	protein histidine kinase activity
SHALO_RS05925	COG1408	metallophosphoesterase
SHALO_RS05930	COG2353	YceI-like domain
SHALO_RS05945	COG1136	(ABC) transporter
SHALO_RS05960	COG0326	Molecular chaperone. Has ATPase activity
SHALO_RS05965	COG3328	transposase activity
SHALO_RS05990	COG0242	peptide deformylase activity
SHALO_RS05995	COG0824	Thioesterase
SHALO_RS06005	COG1573	uracil-dna glycosylase
SHALO_RS06020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHALO_RS06035	COG0745	RESPONSE REGULATOR receiver
SHALO_RS06040	COG2200	EAL domain
SHALO_RS06040	COG3287	FIST C domain
SHALO_RS06040	COG2199	diguanylate cyclase activity
SHALO_RS06050	COG0745	RESPONSE REGULATOR receiver
SHALO_RS06055	COG0426	domain, Protein
SHALO_RS06070	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SHALO_RS06075	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SHALO_RS06080	COG2040	homocysteine
SHALO_RS06085	COG1012	belongs to the aldehyde dehydrogenase family
SHALO_RS06090	COG1196	nuclear chromosome segregation
SHALO_RS06090	COG3264	Mechanosensitive ion channel
SHALO_RS06105	COG1433	Dinitrogenase iron-molybdenum cofactor
SHALO_RS06135	COG0633	Ferredoxin
SHALO_RS06140	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SHALO_RS06170	COG3645	SOS response
SHALO_RS06225	COG1451	nucleotide metabolic process
SHALO_RS06240	COG3041	Addiction module toxin RelE StbE family
SHALO_RS06280	COG0697	spore germination
SHALO_RS06290	COG3706	GGDEF domain
SHALO_RS06295	COG3706	GGDEF domain
SHALO_RS06300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHALO_RS06340	COG0840	transmembrane signaling receptor activity
SHALO_RS06345	COG0243	molybdopterin cofactor binding
SHALO_RS06360	COG0747	negative chemotaxis
SHALO_RS06365	COG0745	RESPONSE REGULATOR receiver
SHALO_RS06380	COG1276	copper resistance
SHALO_RS06385	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SHALO_RS06400	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SHALO_RS06410	COG2205	protein histidine kinase activity
SHALO_RS06415	COG0745	RESPONSE REGULATOR receiver
SHALO_RS06450	COG0745	RESPONSE REGULATOR receiver
SHALO_RS06455	COG0642	Histidine kinase
SHALO_RS06460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SHALO_RS06460	COG3153	acetyltransferase
SHALO_RS06505	COG0840	transmembrane signaling receptor activity
SHALO_RS06505	COG3290	protein histidine kinase activity
SHALO_RS06510	COG0493	'glutamate synthase
SHALO_RS06515	COG0375	protein maturation
SHALO_RS06520	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SHALO_RS06530	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS06540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHALO_RS06575	COG1139	Iron-sulfur cluster binding protein
SHALO_RS06590	COG0523	cobalamin synthesis protein
SHALO_RS06595	COG2879	small protein
SHALO_RS06600	COG1966	Carbon starvation protein
SHALO_RS06610	COG1053	succinate dehydrogenase
SHALO_RS06645	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SHALO_RS06650	COG0585	pseudouridine synthase activity
SHALO_RS06660	COG0475	glutathione-regulated potassium exporter activity
SHALO_RS06660	COG0569	domain protein
SHALO_RS06675	COG3706	GGDEF domain
SHALO_RS06685	COG0351	phosphomethylpyrimidine kinase
SHALO_RS06695	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SHALO_RS06705	COG0428	transporter
SHALO_RS06715	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SHALO_RS06725	COG1234	tRNA 3'-trailer cleavage
SHALO_RS06735	COG0488	(ABC) transporter
SHALO_RS06740	COG1360	Flagellar Motor Protein
SHALO_RS06745	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SHALO_RS06750	COG1309	transcriptional regulator
SHALO_RS06780	COG0778	Nitroreductase
SHALO_RS06785	COG0778	Nitroreductase
SHALO_RS06825	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SHALO_RS06840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHALO_RS06855	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SHALO_RS06870	COG0742	ribosomal rna small subunit methyltransferase
SHALO_RS06875	COG1706	bacterial-type flagellum-dependent cell motility
SHALO_RS06880	COG3951	Flagellar rod assembly protein muramidase FlgJ
SHALO_RS06900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHALO_RS06910	COG0659	secondary active sulfate transmembrane transporter activity
SHALO_RS06915	COG1942	4-Oxalocrotonate Tautomerase
SHALO_RS06920	COG0356	it plays a direct role in the translocation of protons across the membrane
SHALO_RS06935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SHALO_RS06940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SHALO_RS06950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SHALO_RS06955	COG0101	tRNA pseudouridine synthase activity
SHALO_RS06965	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SHALO_RS06975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SHALO_RS06980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SHALO_RS06985	COG1338	Plays a role in the flagellum-specific transport system
SHALO_RS06995	COG1733	regulation of RNA biosynthetic process
SHALO_RS07000	COG2249	NAD(P)H dehydrogenase (quinone) activity
SHALO_RS07015	COG3174	membrane
SHALO_RS07020	COG1032	radical SAM domain protein
SHALO_RS07025	COG0166	Belongs to the GPI family
SHALO_RS07050	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SHALO_RS07055	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SHALO_RS07060	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
SHALO_RS07065	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SHALO_RS07070	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SHALO_RS07075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SHALO_RS07085	COG4774	siderophore transport
SHALO_RS07105	COG0298	carbon dioxide binding
SHALO_RS07110	COG0409	Hydrogenase expression formation protein
SHALO_RS07115	COG0309	Hydrogenase expression formation protein (HypE)
SHALO_RS07125	COG1247	-acetyltransferase
SHALO_RS07130	COG0546	phosphoglycolate phosphatase activity
SHALO_RS07150	COG0039	L-malate dehydrogenase activity
SHALO_RS07155	COG0045	succinate-CoA ligase (ADP-forming) activity
SHALO_RS07160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SHALO_RS07170	COG0674	pyruvate-flavodoxin oxidoreductase activity
SHALO_RS07170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SHALO_RS07175	COG3962	Belongs to the TPP enzyme family
SHALO_RS07200	COG0114	fumarate hydratase activity
SHALO_RS07215	COG2095	MarC family integral membrane protein
SHALO_RS07230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SHALO_RS07235	COG0750	zinc metalloprotease
SHALO_RS07240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SHALO_RS07245	COG1028	Short-chain dehydrogenase reductase Sdr
SHALO_RS07250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SHALO_RS07260	COG0167	dihydroorotate dehydrogenase activity
SHALO_RS07265	COG1132	(ABC) transporter
SHALO_RS07270	COG0215	cysteine-tRNA ligase activity
SHALO_RS07275	COG0728	peptidoglycan biosynthetic process
SHALO_RS07285	COG0632	four-way junction helicase activity
SHALO_RS07290	COG1181	Belongs to the D-alanine--D-alanine ligase family
SHALO_RS07305	COG1254	Belongs to the acylphosphatase family
SHALO_RS07310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SHALO_RS07315	COG0280	phosphate acetyltransferase
SHALO_RS07315	COG0857	belongs to the CobB CobQ family
SHALO_RS07320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SHALO_RS07385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SHALO_RS07390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SHALO_RS07405	COG0137	argininosuccinate synthase activity
SHALO_RS07410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SHALO_RS07415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SHALO_RS07420	COG0802	atpase or kinase
SHALO_RS07425	COG1137	ATPase activity
SHALO_RS07430	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SHALO_RS07490	COG2201	protein-glutamate methylesterase activity
SHALO_RS07505	COG1053	succinate dehydrogenase
SHALO_RS07570	COG0745	RESPONSE REGULATOR receiver
SHALO_RS07580	COG0437	4 iron, 4 sulfur cluster binding
SHALO_RS07590	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SHALO_RS07600	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SHALO_RS07610	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SHALO_RS07620	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SHALO_RS07640	COG1120	ATPase activity
SHALO_RS07655	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SHALO_RS07700	COG1132	(ABC) transporter
SHALO_RS07705	COG1797	cobyrinic acid a,c-diamide synthase activity
SHALO_RS07715	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SHALO_RS07715	COG1648	precorrin-2 dehydrogenase activity
SHALO_RS07720	COG1309	transcriptional regulator
SHALO_RS07825	COG0582	viral genome integration into host DNA
SHALO_RS07835	COG0776	regulation of translation
SHALO_RS07845	COG1196	nuclear chromosome segregation
SHALO_RS07845	COG1674	ftsk spoiiie
SHALO_RS07850	COG1049	propionate catabolic process, 2-methylcitrate cycle
SHALO_RS07855	COG1047	Peptidyl-prolyl cis-trans
SHALO_RS07860	COG0574	Belongs to the PEP-utilizing enzyme family
SHALO_RS07860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SHALO_RS07865	COG2814	Major facilitator Superfamily
SHALO_RS07885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SHALO_RS07895	COG1832	CoA-binding protein
SHALO_RS07900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SHALO_RS07910	COG1126	abc transporter atp-binding protein
SHALO_RS07915	COG0765	amino acid transport
SHALO_RS07920	COG4597	amino acid ABC transporter
SHALO_RS07925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHALO_RS07930	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SHALO_RS07940	COG0586	Pfam SNARE associated Golgi protein
SHALO_RS07950	COG1136	(ABC) transporter
SHALO_RS07950	COG0577	efflux transmembrane transporter activity
SHALO_RS07955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SHALO_RS07970	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SHALO_RS07975	COG0727	PFAM Uncharacterised protein family (UPF0153)
SHALO_RS07985	COG0134	indole-3-glycerol-phosphate synthase activity
SHALO_RS07995	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SHALO_RS08005	COG0310	cobalt ion transport
SHALO_RS08025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SHALO_RS08030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SHALO_RS08045	COG0446	pyridine nucleotide-disulphide oxidoreductase
SHALO_RS08060	COG0028	Belongs to the TPP enzyme family
SHALO_RS08070	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SHALO_RS08080	COG0493	'glutamate synthase
SHALO_RS08085	COG0436	Aminotransferase
SHALO_RS08090	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SHALO_RS08120	COG1045	serine acetyltransferase
SHALO_RS08125	COG1166	arginine decarboxylase activity
SHALO_RS08130	COG0124	histidyl-tRNA synthetase
SHALO_RS08140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SHALO_RS08145	COG0163	prenyltransferase activity
SHALO_RS08165	COG0303	'Molybdopterin
SHALO_RS08170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SHALO_RS08190	COG0471	metal ion transport
SHALO_RS08200	COG1691	(AIR) carboxylase
SHALO_RS08205	COG1606	tRNA processing
SHALO_RS08210	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SHALO_RS08215	COG3875	lactate racemase activity
SHALO_RS08220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SHALO_RS08220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SHALO_RS08230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SHALO_RS08235	COG2205	protein histidine kinase activity
SHALO_RS08235	COG0784	Response regulator, receiver
SHALO_RS08265	COG0582	viral genome integration into host DNA
SHALO_RS08270	COG0343	queuine tRNA-ribosyltransferase activity
SHALO_RS08280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SHALO_RS08290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SHALO_RS08295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SHALO_RS08315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHALO_RS08335	COG2378	regulation of single-species biofilm formation
SHALO_RS08340	COG1187	pseudouridine synthase activity
SHALO_RS08350	COG0028	Belongs to the TPP enzyme family
SHALO_RS08365	COG2066	Belongs to the glutaminase family
SHALO_RS08385	COG1309	transcriptional regulator
SHALO_RS08415	COG1592	Rubrerythrin
SHALO_RS08425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SHALO_RS08430	COG0181	hydroxymethylbilane synthase activity
SHALO_RS08445	COG0442	prolyl-tRNA aminoacylation
SHALO_RS08450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SHALO_RS08455	COG0142	geranyltranstransferase activity
SHALO_RS08475	COG1959	2 iron, 2 sulfur cluster binding
SHALO_RS08485	COG3706	GGDEF domain
SHALO_RS08490	COG0525	valine-tRNA ligase activity
SHALO_RS08495	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SHALO_RS08500	COG0521	Mo-molybdopterin cofactor biosynthetic process
SHALO_RS08510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SHALO_RS08525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SHALO_RS08530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SHALO_RS08540	COG2195	Cleaves the N-terminal amino acid of tripeptides
SHALO_RS08550	COG0500	methyltransferase
SHALO_RS08565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SHALO_RS08570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SHALO_RS08575	COG1663	tetraacyldisaccharide 4'-kinase activity
SHALO_RS08580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SHALO_RS08585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SHALO_RS08590	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SHALO_RS08605	COG4232	protein-disulfide reductase activity
SHALO_RS08615	COG0443	Heat shock 70 kDa protein
SHALO_RS08620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SHALO_RS08625	COG1420	regulation of RNA biosynthetic process
SHALO_RS08640	COG1959	2 iron, 2 sulfur cluster binding
SHALO_RS08645	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SHALO_RS08650	COG2404	hydrolase activity, acting on ester bonds
SHALO_RS08660	COG2226	methyltransferase
SHALO_RS08665	COG3706	GGDEF domain
SHALO_RS08670	COG0196	riboflavin kinase activity
SHALO_RS08675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SHALO_RS08680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SHALO_RS08685	COG0730	response to heat
SHALO_RS08695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SHALO_RS08710	COG0527	aspartate kinase activity
SHALO_RS08715	COG0494	nUDIX hydrolase
SHALO_RS08720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SHALO_RS08730	COG0789	Transcriptional regulator
SHALO_RS08735	COG0484	heat shock protein binding
SHALO_RS08740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SHALO_RS08745	COG0745	RESPONSE REGULATOR receiver
SHALO_RS08750	COG0642	Histidine kinase
SHALO_RS08765	COG0653	protein targeting
SHALO_RS08780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SHALO_RS08785	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SHALO_RS08795	COG0706	membrane insertase activity
SHALO_RS08800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SHALO_RS08805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SHALO_RS08820	COG4865	methylaspartate mutase activity
SHALO_RS08835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SHALO_RS08850	COG0542	response to heat
SHALO_RS08855	COG0793	Belongs to the peptidase S41A family
SHALO_RS08860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SHALO_RS08865	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SHALO_RS08870	COG0047	phosphoribosylformylglycinamidine synthase activity
SHALO_RS08880	COG0204	Acyl-transferase
SHALO_RS08885	COG0326	Molecular chaperone. Has ATPase activity
SHALO_RS08895	COG1331	Highly conserved protein containing a thioredoxin domain
SHALO_RS08900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SHALO_RS08940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SHALO_RS08960	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SHALO_RS08970	COG2608	mercury ion transmembrane transporter activity
SHALO_RS08975	COG2217	Heavy metal translocating P-type atpase
SHALO_RS08980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SHALO_RS08995	COG0275	rRNA processing
SHALO_RS09005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SHALO_RS09010	COG0849	cell division
SHALO_RS09015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SHALO_RS09025	COG2890	protein-(glutamine-N5) methyltransferase activity
SHALO_RS09025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SHALO_RS09030	COG0501	Belongs to the peptidase M48B family
SHALO_RS09045	COG0840	transmembrane signaling receptor activity
SHALO_RS09055	COG2151	metal-sulfur cluster biosynthetic enzyme
SHALO_RS09075	COG0138	bifunctional purine biosynthesis protein purh
SHALO_RS09080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SHALO_RS09090	COG1607	acyl-coa hydrolase
SHALO_RS09095	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SHALO_RS09100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SHALO_RS09120	COG3647	Membrane
SHALO_RS09125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SHALO_RS09135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SHALO_RS09140	COG0805	protein transport
SHALO_RS09145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SHALO_RS09150	COG2831	hemolysin activation secretion protein
SHALO_RS09155	COG3210	domain, Protein
SHALO_RS09155	COG3210	domain, Protein
SHALO_RS09220	COG3437	response regulator, receiver
SHALO_RS09230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SHALO_RS09235	COG1022	Amp-dependent synthetase and ligase
SHALO_RS09245	COG4206	TonB-dependent receptor
SHALO_RS09250	COG2205	protein histidine kinase activity
SHALO_RS09255	COG0745	RESPONSE REGULATOR receiver
SHALO_RS09260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SHALO_RS09270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SHALO_RS09285	COG2068	MobA-Related Protein
SHALO_RS09290	COG3608	succinylglutamate desuccinylase aspartoacylase
SHALO_RS09290	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SHALO_RS09295	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SHALO_RS09300	COG0535	radical SAM domain protein
SHALO_RS09320	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SHALO_RS09330	COG5002	protein histidine kinase activity
SHALO_RS09335	COG0745	RESPONSE REGULATOR receiver
SHALO_RS09345	COG3038	cytochrome b561
SHALO_RS09355	COG0642	Histidine kinase
SHALO_RS09360	COG0745	RESPONSE REGULATOR receiver
SHALO_RS09370	COG1230	cation diffusion facilitator family transporter
SHALO_RS09390	COG4774	siderophore transport
SHALO_RS09400	COG0668	transmembrane transport
SHALO_RS09435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SHALO_RS09445	COG0646	methionine synthase
SHALO_RS09445	COG1410	methionine synthase
SHALO_RS09455	COG0840	transmembrane signaling receptor activity
SHALO_RS09460	COG1280	lysine exporter protein (LysE YggA)
SHALO_RS09475	COG0004	ammonium transporteR
SHALO_RS09480	COG0347	Belongs to the P(II) protein family
SHALO_RS09495	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SHALO_RS09495	COG2199	diguanylate cyclase activity
SHALO_RS09515	COG0288	reversible hydration of carbon dioxide
SHALO_RS09520	COG3123	guanosine phosphorylase activity
SHALO_RS09530	COG2081	HI0933 family
SHALO_RS09540	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SHALO_RS09545	COG0788	formyltetrahydrofolate deformylase activity
SHALO_RS09565	COG0473	3-isopropylmalate dehydrogenase activity
SHALO_RS09570	COG0066	3-isopropylmalate dehydratase activity
SHALO_RS09575	COG1119	ATPase activity
SHALO_RS09600	COG0708	Exodeoxyribonuclease III
SHALO_RS09620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SHALO_RS09625	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SHALO_RS09645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SHALO_RS09650	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SHALO_RS09660	COG3706	GGDEF domain
SHALO_RS09670	COG4895	conserved protein (DUF2196)
SHALO_RS09690	COG0513	Belongs to the DEAD box helicase family
SHALO_RS09700	COG5001	Diguanylate cyclase
SHALO_RS09705	COG0642	Histidine kinase
SHALO_RS09710	COG0745	RESPONSE REGULATOR receiver
SHALO_RS09745	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SHALO_RS09750	COG0372	Belongs to the citrate synthase family
SHALO_RS09755	COG2079	MmgE PrpD family protein
SHALO_RS09765	COG2824	Alkylphosphonate utilization operon protein PhnA
SHALO_RS09775	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SHALO_RS09780	COG4786	Flagellar basal body rod
SHALO_RS09785	COG4786	Flagellar basal body rod
SHALO_RS09790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SHALO_RS09800	COG1733	regulation of RNA biosynthetic process
SHALO_RS09810	COG0655	NAD(P)H dehydrogenase (quinone) activity
SHALO_RS09820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHALO_RS09825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHALO_RS09830	COG3162	membrane
SHALO_RS09835	COG0745	RESPONSE REGULATOR receiver
SHALO_RS09845	COG2957	Belongs to the agmatine deiminase family
SHALO_RS09855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SHALO_RS09860	COG1918	ferrous iron import across plasma membrane
SHALO_RS09885	COG3585	molybdate ion transport
SHALO_RS09895	COG0598	Magnesium transport protein CorA
SHALO_RS09900	COG0739	heme binding
SHALO_RS09910	COG0277	FAD linked oxidase domain protein
SHALO_RS09915	COG1295	ribonuclease BN
SHALO_RS09930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SHALO_RS09935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SHALO_RS09960	COG0556	nucleotide-excision repair
SHALO_RS09965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SHALO_RS09970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SHALO_RS09975	COG2176	DNA-directed DNA polymerase activity
SHALO_RS09980	COG0135	phosphoribosylanthranilate isomerase activity
SHALO_RS09985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SHALO_RS09995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SHALO_RS10010	COG1692	metallophosphoesterase
SHALO_RS10015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SHALO_RS10025	COG0739	heme binding
SHALO_RS10030	COG0285	dihydrofolate synthase activity
SHALO_RS10035	COG3706	GGDEF domain
SHALO_RS10045	COG0495	leucyl-tRNA aminoacylation
SHALO_RS10050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SHALO_RS10055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SHALO_RS10060	COG1862	Preprotein translocase
SHALO_RS10065	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SHALO_RS10070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SHALO_RS10080	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SHALO_RS10085	COG0542	response to heat
SHALO_RS10090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SHALO_RS10100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SHALO_RS10105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SHALO_RS10110	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SHALO_RS10115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SHALO_RS10120	COG0210	DNA helicase
SHALO_RS10150	COG0540	Belongs to the ATCase OTCase family
SHALO_RS10160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SHALO_RS10200	COG0336	Belongs to the RNA methyltransferase TrmD family
SHALO_RS10215	COG0228	four-way junction DNA binding
SHALO_RS10220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SHALO_RS10225	COG0564	pseudouridine synthase activity
SHALO_RS10230	COG1519	Transferase
SHALO_RS10240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SHALO_RS10245	COG0752	glycyl-tRNA synthetase alpha subunit
SHALO_RS10255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SHALO_RS10270	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SHALO_RS10275	COG0174	glutamine synthetase
SHALO_RS10285	COG0444	Belongs to the ABC transporter superfamily
SHALO_RS10290	COG0156	8-amino-7-oxononanoate synthase activity
SHALO_RS10295	COG0424	maF-like protein
SHALO_RS10305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SHALO_RS10320	COG5002	protein histidine kinase activity
SHALO_RS10325	COG0243	molybdopterin cofactor binding
SHALO_RS10330	COG0437	4 iron, 4 sulfur cluster binding
SHALO_RS10335	COG3302	dmso reductase anchor subunit
SHALO_RS10340	COG3381	protein complex oligomerization
SHALO_RS10355	COG1028	Short-chain dehydrogenase reductase Sdr
SHALO_RS10365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SHALO_RS10380	COG1558	bacterial-type flagellum-dependent cell motility
SHALO_RS10385	COG1815	bacterial-type flagellum-dependent cell motility
SHALO_RS10390	COG0772	Belongs to the SEDS family
SHALO_RS10395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SHALO_RS10410	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SHALO_RS10420	COG0697	spore germination
SHALO_RS10460	COG0512	Glutamine amidotransferase of anthranilate synthase
SHALO_RS10465	COG2814	Major facilitator Superfamily
SHALO_RS10475	COG0640	Transcriptional regulator
SHALO_RS10500	COG2301	Belongs to the HpcH HpaI aldolase family
SHALO_RS10515	COG3180	Ammonia monooxygenase
SHALO_RS10525	COG3290	protein histidine kinase activity
SHALO_RS10530	COG4565	transcriptional regulatory protein
SHALO_RS10550	COG5002	protein histidine kinase activity
SHALO_RS10550	COG2205	protein histidine kinase activity
SHALO_RS10550	COG0784	Response regulator, receiver
SHALO_RS10555	COG3437	response regulator, receiver
SHALO_RS10560	COG2814	Major facilitator Superfamily
SHALO_RS10570	COG2252	PERMEase
SHALO_RS10575	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SHALO_RS10590	COG0133	tryptophan synthase activity
SHALO_RS10600	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SHALO_RS10605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHALO_RS10620	COG3706	GGDEF domain
SHALO_RS10650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SHALO_RS10670	COG0488	(ABC) transporter
SHALO_RS10680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SHALO_RS10700	COG0651	ATP synthesis coupled electron transport
SHALO_RS10705	COG0650	Formate hydrogenlyase subunit 4
SHALO_RS10710	COG4237	Hydrogenase 4 membrane
SHALO_RS10715	COG0651	ATP synthesis coupled electron transport
SHALO_RS10720	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SHALO_RS10720	COG3261	NADH dehydrogenase
SHALO_RS10730	COG3260	NADH ubiquinone oxidoreductase 20
SHALO_RS10755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SHALO_RS10765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SHALO_RS10785	COG2171	N-acyltransferase activity
SHALO_RS10790	COG0489	protein tyrosine kinase activity
SHALO_RS10795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SHALO_RS10795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SHALO_RS10805	COG2046	Belongs to the sulfate adenylyltransferase family
SHALO_RS10820	COG2353	YceI-like domain
SHALO_RS10825	COG1739	Uncharacterized protein family UPF0029
SHALO_RS10830	COG0157	Belongs to the NadC ModD family
SHALO_RS10835	COG4149	molybdate abc transporter
SHALO_RS10845	COG3842	ATPase activity
SHALO_RS10870	COG1686	Belongs to the peptidase S11 family
SHALO_RS10875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SHALO_RS10880	COG0577	efflux transmembrane transporter activity
SHALO_RS10880	COG1136	(ABC) transporter
SHALO_RS10885	COG1136	(ABC) transporter
SHALO_RS10885	COG0577	efflux transmembrane transporter activity
SHALO_RS10890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SHALO_RS10910	COG0668	transmembrane transport
SHALO_RS10975	COG0284	orotidine-5'-phosphate decarboxylase activity
SHALO_RS10980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SHALO_RS10985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SHALO_RS11000	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SHALO_RS11005	COG0697	spore germination
SHALO_RS11010	COG0668	transmembrane transport
SHALO_RS11015	COG1160	GTP binding
SHALO_RS11020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SHALO_RS11030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SHALO_RS11040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHALO_RS11045	COG1183	phosphatidylcholine synthase activity
SHALO_RS11055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SHALO_RS11060	COG2264	protein methyltransferase activity
SHALO_RS11065	COG0745	RESPONSE REGULATOR receiver
SHALO_RS11070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SHALO_RS11075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SHALO_RS11085	COG1287	oligosaccharyl transferase activity
SHALO_RS11090	COG1086	Polysaccharide biosynthesis protein
SHALO_RS11095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SHALO_RS11110	COG0110	maltose O-acetyltransferase activity
SHALO_RS11125	COG1216	Glycosyl transferase, family 2
SHALO_RS11140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SHALO_RS11145	COG1088	dTDP-glucose 4,6-dehydratase activity
SHALO_RS11150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHALO_RS11160	COG0028	Belongs to the TPP enzyme family
SHALO_RS11170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SHALO_RS11175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SHALO_RS11185	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SHALO_RS11200	COG1793	dna ligase
SHALO_RS11210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SHALO_RS11215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SHALO_RS11265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SHALO_RS11270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SHALO_RS11270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SHALO_RS11275	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SHALO_RS11295	COG2217	Heavy metal translocating P-type atpase
SHALO_RS11295	COG2608	mercury ion transmembrane transporter activity
SHALO_RS11300	COG5001	Diguanylate cyclase
SHALO_RS11300	COG5002	protein histidine kinase activity
SHALO_RS11305	COG0697	spore germination
SHALO_RS11335	COG0840	transmembrane signaling receptor activity
SHALO_RS11340	COG1984	allophanate hydrolase subunit 2
SHALO_RS11350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SHALO_RS11370	COG2201	protein-glutamate methylesterase activity
SHALO_RS11380	COG0445	tRNA wobble uridine modification
SHALO_RS11385	COG0723	plastoquinol--plastocyanin reductase activity
SHALO_RS11405	COG0825	malonyl-CoA metabolic process
SHALO_RS11410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHALO_RS11415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHALO_RS11425	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SHALO_RS11430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SHALO_RS11435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SHALO_RS11445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SHALO_RS11465	COG1682	transport, permease protein
SHALO_RS11470	COG1088	dTDP-glucose 4,6-dehydratase activity
SHALO_RS11485	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SHALO_RS11490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SHALO_RS11515	COG0745	RESPONSE REGULATOR receiver
SHALO_RS11530	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SHALO_RS11545	COG0390	transport system, permease component
SHALO_RS11550	COG0439	Biotin carboxylase
SHALO_RS11565	COG0306	phosphate transporter
SHALO_RS11570	COG0513	Belongs to the DEAD box helicase family
SHALO_RS11575	COG1671	Belongs to the UPF0178 family
SHALO_RS11600	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SHALO_RS11605	COG0038	chloride channel
SHALO_RS11615	COG1979	alcohol dehydrogenase
SHALO_RS11630	COG0519	Catalyzes the synthesis of GMP from XMP
SHALO_RS11650	COG0668	transmembrane transport
SHALO_RS11660	COG0546	phosphoglycolate phosphatase activity
SHALO_RS11665	COG1013	pyruvate-flavodoxin oxidoreductase activity
SHALO_RS11665	COG0674	pyruvate-flavodoxin oxidoreductase activity
SHALO_RS11665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SHALO_RS11665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SHALO_RS11670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SHALO_RS11700	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SHALO_RS11705	COG3787	Belongs to the UPF0306 family
SHALO_RS11725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SHALO_RS11740	COG0477	Major facilitator Superfamily
SHALO_RS11745	COG2814	Major facilitator Superfamily
SHALO_RS11755	COG0475	glutathione-regulated potassium exporter activity
SHALO_RS11760	COG1702	phosphate starvation-inducible protein PhoH
SHALO_RS11785	COG0602	queuosine metabolic process
SHALO_RS11790	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SHALO_RS11800	COG2249	NAD(P)H dehydrogenase (quinone) activity
SHALO_RS11805	COG1733	regulation of RNA biosynthetic process
SHALO_RS11820	COG1607	acyl-coa hydrolase
SHALO_RS11830	COG0745	RESPONSE REGULATOR receiver
SHALO_RS11850	COG3290	protein histidine kinase activity
SHALO_RS11850	COG0840	transmembrane signaling receptor activity
SHALO_RS11855	COG3384	dioxygenase
SHALO_RS11860	COG0840	transmembrane signaling receptor activity
SHALO_RS11860	COG3290	protein histidine kinase activity
SHALO_RS11865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SHALO_RS11870	COG0573	inorganic phosphate transmembrane transporter activity
SHALO_RS11880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SHALO_RS11915	COG3976	FMN-binding domain protein
SHALO_RS11915	COG1053	succinate dehydrogenase
SHALO_RS11930	COG4680	protein conserved in bacteria
SHALO_RS11935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SHALO_RS11940	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SHALO_RS11985	COG3278	Belongs to the heme-copper respiratory oxidase family
SHALO_RS11990	COG0745	RESPONSE REGULATOR receiver
SHALO_RS12005	COG0505	Belongs to the CarA family
SHALO_RS12025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SHALO_RS12030	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SHALO_RS12035	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SHALO_RS12045	COG0840	transmembrane signaling receptor activity
SHALO_RS12050	COG0546	phosphoglycolate phosphatase activity
SHALO_RS12055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SHALO_RS12070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SHALO_RS12075	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SHALO_RS12080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SHALO_RS12095	COG0203	ribosomal protein L17
SHALO_RS12105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SHALO_RS12110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SHALO_RS12115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SHALO_RS12120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SHALO_RS12130	COG0024	Methionine aminopeptidase
SHALO_RS12135	COG0201	protein transport
SHALO_RS12140	COG0200	Binds to the 23S rRNA
SHALO_RS12145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SHALO_RS12150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SHALO_RS12155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SHALO_RS12160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SHALO_RS12175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SHALO_RS12180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SHALO_RS12185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SHALO_RS12190	COG0255	Belongs to the universal ribosomal protein uL29 family
SHALO_RS12195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SHALO_RS12200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SHALO_RS12210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SHALO_RS12215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SHALO_RS12220	COG0089	rRNA binding
SHALO_RS12225	COG0088	Forms part of the polypeptide exit tunnel
SHALO_RS12230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SHALO_RS12235	COG0051	transcription antitermination factor activity, RNA binding
SHALO_RS12250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SHALO_RS12255	COG0672	)-iron permease
SHALO_RS12280	COG1136	(ABC) transporter
SHALO_RS12280	COG0577	efflux transmembrane transporter activity
SHALO_RS12300	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SHALO_RS12305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SHALO_RS12310	COG0571	ribonuclease III activity
SHALO_RS12315	COG0328	RNA-DNA hybrid ribonuclease activity
SHALO_RS12325	COG0358	DNA primase activity
SHALO_RS12330	COG0137	argininosuccinate synthase activity
SHALO_RS12335	COG2201	protein-glutamate methylesterase activity
SHALO_RS12355	COG0840	transmembrane signaling receptor activity
SHALO_RS12360	COG2201	protein-glutamate methylesterase activity
SHALO_RS12365	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SHALO_RS12370	COG2205	protein histidine kinase activity
SHALO_RS12375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SHALO_RS12380	COG0643	Histidine kinase
SHALO_RS12380	COG2198	Histidine kinase
SHALO_RS12390	COG0840	transmembrane signaling receptor activity
SHALO_RS12395	COG0835	chemotaxis
SHALO_RS12400	COG0745	RESPONSE REGULATOR receiver
SHALO_RS12425	COG0737	Belongs to the 5'-nucleotidase family
SHALO_RS12435	COG3258	Cytochrome c
SHALO_RS12480	COG0785	Cytochrome C biogenesis protein
SHALO_RS12545	COG1585	Membrane protein implicated in regulation of membrane protease activity
SHALO_RS12550	COG2268	Band 7 protein
SHALO_RS12620	COG4206	TonB-dependent receptor
SHALO_RS12635	COG1918	ferrous iron import across plasma membrane
SHALO_RS12635	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SHALO_RS12640	COG1918	ferrous iron import across plasma membrane
SHALO_RS12650	COG4773	Receptor
SHALO_RS12665	COG2382	esterase
SHALO_RS12670	COG4774	siderophore transport
SHALO_RS12680	COG0848	biopolymer transport protein
SHALO_RS12685	COG0811	peptide transport
SHALO_RS12690	COG1230	cation diffusion facilitator family transporter
SHALO_RS12695	COG1971	Probably functions as a manganese efflux pump
SHALO_RS12710	COG1132	(ABC) transporter
SHALO_RS12720	COG4771	TonB-dependent receptor
SHALO_RS12725	COG4771	TonB-dependent receptor
SHALO_RS12730	COG2207	Transcriptional regulator
SHALO_RS12730	COG3708	Transcriptional regulator
SHALO_RS12740	COG3706	GGDEF domain
SHALO_RS12765	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SHALO_RS12780	COG1011	Hydrolase
SHALO_RS12785	COG1742	UPF0060 membrane protein
SHALO_RS12795	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SHALO_RS12800	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SHALO_RS12820	COG1280	lysine exporter protein (LysE YggA)
SHALO_RS12825	COG1090	epimerase
SHALO_RS12840	COG1136	(ABC) transporter
SHALO_RS12840	COG0577	efflux transmembrane transporter activity
SHALO_RS12870	COG2962	Rard protein
SHALO_RS12880	COG0642	Histidine kinase
SHALO_RS12885	COG2194	sulfuric ester hydrolase activity
SHALO_RS12895	COG2200	EAL domain
SHALO_RS12915	COG4191	Histidine kinase
SHALO_RS12935	COG1342	Belongs to the UPF0251 family
SHALO_RS12940	COG1968	undecaprenyl-diphosphatase activity
SHALO_RS12945	COG4948	Mandelate Racemase Muconate Lactonizing
SHALO_RS12950	COG1464	Belongs to the NlpA lipoprotein family
SHALO_RS12960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SHALO_RS12965	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SHALO_RS12970	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SHALO_RS12995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SHALO_RS13015	COG0859	PFAM glycosyl transferase family 9
SHALO_RS13015	COG0457	Tetratricopeptide repeat
SHALO_RS13040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SHALO_RS13045	COG4774	siderophore transport
SHALO_RS13050	COG1027	Aspartate ammonia-lyase
SHALO_RS13055	COG1027	Aspartate ammonia-lyase
SHALO_RS13060	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SHALO_RS13065	COG0252	asparaginase activity
SHALO_RS13075	COG0745	RESPONSE REGULATOR receiver
SHALO_RS13090	COG0765	amino acid transport
SHALO_RS13115	COG1136	(ABC) transporter
SHALO_RS13140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SHALO_RS13140	COG1333	cytochrome c biogenesis protein
SHALO_RS13145	COG3301	Polysulphide reductase, NrfD
SHALO_RS13150	COG0437	4 iron, 4 sulfur cluster binding
SHALO_RS13155	COG0545	Peptidyl-prolyl cis-trans isomerase
SHALO_RS13160	COG0484	heat shock protein binding
SHALO_RS13170	COG0745	RESPONSE REGULATOR receiver
SHALO_RS13175	COG0840	transmembrane signaling receptor activity
SHALO_RS13185	COG1733	regulation of RNA biosynthetic process
SHALO_RS13190	COG2249	NAD(P)H dehydrogenase (quinone) activity
SHALO_RS13195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SHALO_RS13220	COG0848	biopolymer transport protein
SHALO_RS13225	COG0811	peptide transport
SHALO_RS13230	COG0709	Synthesizes selenophosphate from selenide and ATP
SHALO_RS13235	COG0425	Belongs to the sulfur carrier protein TusA family
SHALO_RS13255	COG3447	MASE1 domain protein
SHALO_RS13255	COG5002	protein histidine kinase activity
SHALO_RS13255	COG5001	Diguanylate cyclase
SHALO_RS13265	COG2814	Major facilitator Superfamily
SHALO_RS13290	COG4662	Binding-protein-dependent transport system inner membrane component
SHALO_RS13295	COG2998	abc-type tungstate transport system, permease component
SHALO_RS13305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SHALO_RS13315	COG0437	4 iron, 4 sulfur cluster binding
SHALO_RS13345	COG1120	ATPase activity
SHALO_RS13360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHALO_RS13375	COG0848	biopolymer transport protein
SHALO_RS13380	COG0811	peptide transport
SHALO_RS13410	COG0500	methyltransferase
SHALO_RS13420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SHALO_RS13445	COG1917	Cupin 2, conserved barrel domain protein
SHALO_RS13445	COG4977	sequence-specific DNA binding
SHALO_RS13455	COG0437	4 iron, 4 sulfur cluster binding
SHALO_RS13495	COG4191	Histidine kinase
SHALO_RS13500	COG0745	RESPONSE REGULATOR receiver
SHALO_RS13505	COG1921	L-seryl-tRNASec selenium transferase activity
SHALO_RS13515	COG2048	Heterodisulfide reductase, subunit B
SHALO_RS13520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SHALO_RS13525	COG1053	succinate dehydrogenase
SHALO_RS13535	COG1846	Transcriptional regulator
SHALO_RS13545	COG1741	Belongs to the pirin family
SHALO_RS13580	COG0745	RESPONSE REGULATOR receiver
SHALO_RS13585	COG0642	Histidine kinase
SHALO_RS13615	COG2986	histidine ammonia-lyase
SHALO_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
SHALO_RS13680	COG0513	Belongs to the DEAD box helicase family
SHALO_RS13695	COG1280	lysine exporter protein (LysE YggA)
SHALO_RS13715	COG1305	Transglutaminase-like
SHALO_RS13730	COG0745	RESPONSE REGULATOR receiver
SHALO_RS13745	COG0439	Biotin carboxylase
SHALO_RS13755	COG3665	Urea carboxylase-associated protein
SHALO_RS13760	COG3842	ATPase activity
SHALO_RS13765	COG2011	ABC-type metal ion transport system permease component
SHALO_RS13775	COG0642	Histidine kinase
SHALO_RS13780	COG0745	RESPONSE REGULATOR receiver
SHALO_RS13805	COG0745	RESPONSE REGULATOR receiver
SHALO_RS13810	COG2205	protein histidine kinase activity
SHALO_RS13815	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SHALO_RS13820	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SHALO_RS13825	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SHALO_RS13830	COG1028	Short-chain dehydrogenase reductase Sdr
SHALO_RS13845	COG0300	oxidoreductase activity
SHALO_RS13860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SHALO_RS13865	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SHALO_RS13870	COG2814	Major facilitator Superfamily
SHALO_RS13875	COG1238	metal cluster binding
SHALO_RS13895	COG0303	'Molybdopterin
SHALO_RS13900	COG0314	molybdopterin synthase activity
SHALO_RS13915	COG1104	cysteine desulfurase activity
SHALO_RS13920	COG1157	protein secretion by the type III secretion system
SHALO_RS13925	COG0302	gtp cyclohydrolase
SHALO_RS13930	COG0544	peptidyl-prolyl cis-trans isomerase activity
SHALO_RS13935	COG0740	serine-type endopeptidase activity
SHALO_RS13955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SHALO_RS13955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SHALO_RS13965	COG2022	thiamine diphosphate biosynthetic process
SHALO_RS14030	COG0437	4 iron, 4 sulfur cluster binding
SHALO_RS14035	COG0243	molybdopterin cofactor binding
SHALO_RS14055	COG0745	RESPONSE REGULATOR receiver
SHALO_RS14060	COG0642	Histidine kinase
SHALO_RS14070	COG1012	belongs to the aldehyde dehydrogenase family
SHALO_RS14085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SHALO_RS14110	COG2183	response to ionizing radiation
SHALO_RS14125	COG0778	Nitroreductase
SHALO_RS14135	COG0471	metal ion transport
SHALO_RS14140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SHALO_RS14150	COG0842	Transport permease protein
SHALO_RS14155	COG0842	Transport permease protein
SHALO_RS14160	COG1131	(ABC) transporter
SHALO_RS14165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SHALO_RS14170	COG1309	transcriptional regulator
SHALO_RS14205	COG1053	succinate dehydrogenase
SHALO_RS14205	COG3976	FMN-binding domain protein
SHALO_RS14230	COG0454	-acetyltransferase
SHALO_RS14235	COG0431	NADPH-dependent FMN reductase
SHALO_RS14245	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SHALO_RS14250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SHALO_RS14275	COG0745	RESPONSE REGULATOR receiver
SHALO_RS14280	COG0642	Histidine kinase
SHALO_RS14285	COG3842	ATPase activity
SHALO_RS14290	COG1178	ABC-type Fe3 transport system permease component
SHALO_RS14295	COG1840	ABC-type Fe3 transport system, periplasmic component
SHALO_RS14310	COG0175	sulfate reduction
SHALO_RS14315	COG0175	sulfate reduction
SHALO_RS14320	COG2895	sulfate adenylyltransferase (ATP) activity
SHALO_RS14330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SHALO_RS14340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHALO_RS14345	COG1648	precorrin-2 dehydrogenase activity
SHALO_RS14345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SHALO_RS14350	COG2873	o-acetylhomoserine
SHALO_RS14360	COG0482	sulfurtransferase activity
SHALO_RS14380	COG5002	protein histidine kinase activity
SHALO_RS14390	COG2199	diguanylate cyclase activity
SHALO_RS14390	COG2203	Gaf domain
SHALO_RS14415	COG4232	protein-disulfide reductase activity
SHALO_RS14420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHALO_RS14425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SHALO_RS14430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHALO_RS14440	COG0243	molybdopterin cofactor binding
SHALO_RS14455	COG1136	(ABC) transporter
SHALO_RS14455	COG0577	efflux transmembrane transporter activity
SHALO_RS14460	COG1136	(ABC) transporter
SHALO_RS14470	COG0745	RESPONSE REGULATOR receiver
SHALO_RS14470	COG4191	Histidine kinase
SHALO_RS14470	COG2205	protein histidine kinase activity
SHALO_RS14485	COG0243	molybdopterin cofactor binding
SHALO_RS14495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SHALO_RS14510	COG0861	Integral membrane protein TerC family
SHALO_RS14515	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SHALO_RS14520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SHALO_RS14525	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SHALO_RS14530	COG0281	malic enzyme
SHALO_RS14530	COG0280	phosphate acetyltransferase
SHALO_RS14535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SHALO_RS14545	COG0439	Biotin carboxylase
SHALO_RS14550	COG0511	ligase activity, forming carbon-carbon bonds
SHALO_RS14555	COG0717	Belongs to the dCTP deaminase family
SHALO_RS14570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SHALO_RS14585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SHALO_RS14590	COG1086	Polysaccharide biosynthesis protein
SHALO_RS14595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SHALO_RS14600	COG1083	cytidylyl-transferase
SHALO_RS14605	COG3980	spore coat polysaccharide biosynthesis protein
SHALO_RS14615	COG2089	acid synthase
SHALO_RS14635	COG0367	asparagine synthase
SHALO_RS14650	COG0275	rRNA processing
SHALO_RS14655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHALO_RS14675	COG0367	asparagine synthase
SHALO_RS14680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHALO_RS14705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SHALO_RS14710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SHALO_RS14715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SHALO_RS14720	COG0372	Belongs to the citrate synthase family
SHALO_RS14735	COG0148	phosphopyruvate hydratase activity
SHALO_RS14740	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SHALO_RS14745	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SHALO_RS14750	COG1987	bacterial-type flagellum assembly
SHALO_RS14755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SHALO_RS14760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SHALO_RS14790	COG1408	metallophosphoesterase
SHALO_RS14795	COG1115	amino acid carrier protein
SHALO_RS14800	COG2233	PERMEase
SHALO_RS14805	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SHALO_RS14810	COG0575	Belongs to the CDS family
SHALO_RS14825	COG1929	Belongs to the glycerate kinase type-1 family
SHALO_RS14830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SHALO_RS14850	COG0753	catalase activity
SHALO_RS14855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SHALO_RS14865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SHALO_RS14870	COG0746	molybdenum cofactor guanylyltransferase activity
SHALO_RS14900	COG0724	RNA recognition motif
SHALO_RS14905	COG0315	cyclic pyranopterin monophosphate synthase activity
SHALO_RS14950	COG1140	nitrate reductase beta subunit
SHALO_RS14955	COG0243	molybdopterin cofactor binding
SHALO_RS14960	COG2897	thiosulfate sulfurtransferase activity
SHALO_RS14970	COG0489	protein tyrosine kinase activity
SHALO_RS15015	COG0670	Belongs to the BI1 family
SHALO_RS15065	COG0437	4 iron, 4 sulfur cluster binding
SHALO_RS15070	COG0243	molybdopterin cofactor binding
SHALO_RS15075	COG4106	trans-aconitate 2-methyltransferase activity
SHALO_RS15085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SHALO_RS15090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SHALO_RS15100	COG0233	cytoplasmic translational termination
SHALO_RS15105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SHALO_RS15130	COG1704	LemA family
SHALO_RS15150	COG4786	Flagellar basal body rod
SHALO_RS15155	COG1749	Flagellar hook protein flgE
SHALO_RS15170	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SHALO_RS15175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SHALO_RS15205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SHALO_RS15205	COG2169	Transcriptional regulator
SHALO_RS15345	COG0840	transmembrane signaling receptor activity