locus-tag	class	description
SMUL_RS00010	COG0592	DNA-directed DNA polymerase activity
SMUL_RS00015	COG0187	DNA topoisomerase II activity
SMUL_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMUL_RS00035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMUL_RS00050	COG4175	Glycine betaine
SMUL_RS00055	COG4176	ABC-type proline glycine betaine transport system permease component
SMUL_RS00060	COG2113	Glycine betaine
SMUL_RS00065	COG2814	Major facilitator Superfamily
SMUL_RS00075	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SMUL_RS00085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMUL_RS00090	COG0066	3-isopropylmalate dehydratase activity
SMUL_RS00130	COG2801	Transposase and inactivated derivatives
SMUL_RS00135	COG2963	transposase activity
SMUL_RS00150	COG3328	transposase activity
SMUL_RS00215	COG0840	transmembrane signaling receptor activity
SMUL_RS00240	COG2801	Transposase and inactivated derivatives
SMUL_RS00250	COG0745	RESPONSE REGULATOR receiver
SMUL_RS00255	COG3328	transposase activity
SMUL_RS00275	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SMUL_RS00290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMUL_RS00295	COG1335	isochorismatase
SMUL_RS00310	COG2207	Transcriptional regulator
SMUL_RS00315	COG1053	succinate dehydrogenase
SMUL_RS00320	COG0039	L-malate dehydrogenase activity
SMUL_RS00325	COG0045	succinate-CoA ligase (ADP-forming) activity
SMUL_RS00340	COG1355	regulation of microtubule-based process
SMUL_RS00365	COG2169	Transcriptional regulator
SMUL_RS00365	COG1917	Cupin 2, conserved barrel domain protein
SMUL_RS00375	COG3150	esterase
SMUL_RS00380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMUL_RS00390	COG3383	formate dehydrogenase (NAD+) activity
SMUL_RS00445	COG2095	MarC family integral membrane protein
SMUL_RS00465	COG1120	ATPase activity
SMUL_RS00470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMUL_RS00505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMUL_RS00510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMUL_RS00515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMUL_RS00535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMUL_RS00535	COG1328	CTP reductase activity
SMUL_RS00540	COG1794	racemase activity, acting on amino acids and derivatives
SMUL_RS00545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMUL_RS00550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMUL_RS00555	COG0564	pseudouridine synthase activity
SMUL_RS00560	COG0179	Fumarylacetoacetate (FAA) hydrolase
SMUL_RS00565	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMUL_RS00575	COG0107	imidazoleglycerol-phosphate synthase activity
SMUL_RS00585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SMUL_RS00590	COG0517	IMP dehydrogenase activity
SMUL_RS00590	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SMUL_RS00595	COG1187	pseudouridine synthase activity
SMUL_RS00600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMUL_RS00600	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMUL_RS00610	COG2257	FlhB HrpN YscU SpaS Family
SMUL_RS00620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMUL_RS00625	COG0237	dephospho-CoA kinase activity
SMUL_RS00630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SMUL_RS00640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMUL_RS00645	COG0268	Binds directly to 16S ribosomal RNA
SMUL_RS00660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMUL_RS00665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMUL_RS00675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMUL_RS00680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMUL_RS00685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMUL_RS00690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMUL_RS00695	COG0348	domain, Protein
SMUL_RS00705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SMUL_RS00720	COG0754	glutathionylspermidine amidase activity
SMUL_RS00735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMUL_RS00765	COG0642	Histidine kinase
SMUL_RS00770	COG0745	RESPONSE REGULATOR receiver
SMUL_RS00785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SMUL_RS00790	COG1127	ABC transporter
SMUL_RS00795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SMUL_RS00805	COG2095	MarC family integral membrane protein
SMUL_RS00860	COG0004	ammonium transporteR
SMUL_RS00875	COG0667	Aldo Keto reductase
SMUL_RS00885	COG0745	RESPONSE REGULATOR receiver
SMUL_RS00900	COG0765	amino acid transport
SMUL_RS00925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMUL_RS00930	COG1121	(ABC) transporter
SMUL_RS00950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SMUL_RS00960	COG0318	PFAM AMP-dependent synthetase and ligase
SMUL_RS00965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMUL_RS00970	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS00975	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS00980	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS00985	COG0649	NAD binding
SMUL_RS01005	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMUL_RS01010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS01015	COG0839	Belongs to the complex I subunit 6 family
SMUL_RS01020	COG0713	ATP synthesis coupled electron transport
SMUL_RS01025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMUL_RS01030	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS01035	COG1007	ATP synthesis coupled electron transport
SMUL_RS01060	COG1012	belongs to the aldehyde dehydrogenase family
SMUL_RS01065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMUL_RS01085	COG0840	transmembrane signaling receptor activity
SMUL_RS01095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMUL_RS01100	COG0303	'Molybdopterin
SMUL_RS01110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMUL_RS01115	COG0254	rRNA binding
SMUL_RS01120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SMUL_RS01140	COG0436	Aminotransferase
SMUL_RS01145	COG0460	homoserine dehydrogenase
SMUL_RS01150	COG0792	nuclease activity
SMUL_RS01155	COG3118	belongs to the thioredoxin family
SMUL_RS01160	COG0492	ferredoxin-NADP+ reductase activity
SMUL_RS01165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMUL_RS01170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMUL_RS01175	COG1242	4 iron, 4 sulfur cluster binding
SMUL_RS01190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMUL_RS01190	COG0140	phosphoribosyl-ATP diphosphatase activity
SMUL_RS01205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SMUL_RS01215	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMUL_RS01220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMUL_RS01225	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMUL_RS01230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMUL_RS01235	COG1077	Cell shape determining protein MreB Mrl
SMUL_RS01245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMUL_RS01270	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMUL_RS01275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SMUL_RS01280	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMUL_RS01315	COG2963	transposase activity
SMUL_RS01320	COG2801	Transposase and inactivated derivatives
SMUL_RS01325	COG3328	transposase activity
SMUL_RS01330	COG2801	Transposase and inactivated derivatives
SMUL_RS01360	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS01365	COG0243	molybdopterin cofactor binding
SMUL_RS01385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMUL_RS01390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMUL_RS01400	COG0835	chemotaxis
SMUL_RS01400	COG0784	Response regulator, receiver
SMUL_RS01405	COG2198	Histidine kinase
SMUL_RS01405	COG0784	Response regulator, receiver
SMUL_RS01405	COG0643	Histidine kinase
SMUL_RS01410	COG0835	chemotaxis
SMUL_RS01420	COG0560	Phosphoserine phosphatase
SMUL_RS01425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SMUL_RS01455	COG0193	aminoacyl-tRNA hydrolase activity
SMUL_RS01465	COG0019	diaminopimelate decarboxylase activity
SMUL_RS01470	COG1605	Chorismate mutase
SMUL_RS01470	COG0077	Prephenate dehydratase
SMUL_RS01475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMUL_RS01485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMUL_RS01495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMUL_RS01505	COG0450	alkyl hydroperoxide reductase
SMUL_RS01510	COG0840	transmembrane signaling receptor activity
SMUL_RS01520	COG0105	UTP biosynthetic process
SMUL_RS01530	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMUL_RS01540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMUL_RS01545	COG0287	Prephenate dehydrogenase
SMUL_RS01550	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMUL_RS01555	COG0248	Ppx GppA phosphatase
SMUL_RS01560	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_RS01570	COG0745	RESPONSE REGULATOR receiver
SMUL_RS01580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMUL_RS01590	COG0157	Belongs to the NadC ModD family
SMUL_RS01595	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMUL_RS01610	COG0850	regulation of cytokinetic process
SMUL_RS01615	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SMUL_RS01625	COG0083	homoserine kinase activity
SMUL_RS01645	COG0779	Required for maturation of 30S ribosomal subunits
SMUL_RS01650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMUL_RS01650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMUL_RS01670	COG5002	protein histidine kinase activity
SMUL_RS01685	COG3258	Cytochrome c
SMUL_RS01695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMUL_RS01695	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SMUL_RS01710	COG0243	molybdopterin cofactor binding
SMUL_RS01715	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS01720	COG3301	Polysulphide reductase, NrfD
SMUL_RS01725	COG3287	FIST C domain
SMUL_RS01725	COG2200	EAL domain
SMUL_RS01725	COG2199	diguanylate cyclase activity
SMUL_RS01735	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS01740	COG3301	Polysulphide reductase, NrfD
SMUL_RS01745	COG0745	RESPONSE REGULATOR receiver
SMUL_RS01750	COG5002	protein histidine kinase activity
SMUL_RS01760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMUL_RS01770	COG1227	inorganic diphosphatase activity
SMUL_RS01790	COG1570	exodeoxyribonuclease VII activity
SMUL_RS01815	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMUL_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
SMUL_RS01825	COG2207	Transcriptional regulator
SMUL_RS01830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMUL_RS01835	COG0583	DNA-binding transcription factor activity
SMUL_RS01840	COG2855	membrane
SMUL_RS01845	COG0386	Belongs to the glutathione peroxidase family
SMUL_RS01865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMUL_RS01875	COG0402	S-adenosylhomocysteine deaminase activity
SMUL_RS01880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SMUL_RS01885	COG0006	proline dipeptidase activity
SMUL_RS01890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SMUL_RS01895	COG1419	protein localization to endoplasmic reticulum
SMUL_RS01900	COG0455	bacterial-type flagellum organization
SMUL_RS01910	COG1191	sigma factor activity
SMUL_RS01915	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMUL_RS01920	COG1776	CheC inhibitor of MCP methylation
SMUL_RS01920	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMUL_RS01925	COG1611	Belongs to the LOG family
SMUL_RS01935	COG0463	Glycosyl transferase, family 2
SMUL_RS01945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMUL_RS01950	COG2076	Multidrug Resistance protein
SMUL_RS01965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMUL_RS01975	COG1040	competence protein
SMUL_RS02005	COG2204	response regulator
SMUL_RS02010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMUL_RS02020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SMUL_RS02025	COG0731	radical SAM domain protein
SMUL_RS02035	COG2358	TRAP transporter, solute receptor (TAXI family
SMUL_RS02045	COG0582	viral genome integration into host DNA
SMUL_RS02070	COG3328	transposase activity
SMUL_RS02165	COG0419	ATPase involved in DNA repair
SMUL_RS02175	COG3328	transposase activity
SMUL_RS02200	COG0039	L-malate dehydrogenase activity
SMUL_RS02210	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SMUL_RS02215	COG1834	amidinotransferase
SMUL_RS02225	COG0693	protein deglycase activity
SMUL_RS02255	COG2199	diguanylate cyclase activity
SMUL_RS02255	COG2200	EAL domain
SMUL_RS02255	COG3287	FIST C domain
SMUL_RS02270	COG3118	belongs to the thioredoxin family
SMUL_RS02280	COG4336	lyase activity
SMUL_RS02305	COG4628	conserved protein (DUF2132)
SMUL_RS02310	COG4221	oxidoreductase activity
SMUL_RS02325	COG0683	leucine binding
SMUL_RS02350	COG1012	belongs to the aldehyde dehydrogenase family
SMUL_RS02365	COG3022	response to hydroperoxide
SMUL_RS02390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMUL_RS02395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMUL_RS02405	COG0250	Participates in transcription elongation, termination and antitermination
SMUL_RS02410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMUL_RS02415	COG0081	regulation of translation
SMUL_RS02420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMUL_RS02425	COG0222	ribosome binding
SMUL_RS02430	COG0085	RNA polymerase activity
SMUL_RS02435	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMUL_RS02440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMUL_RS02450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMUL_RS02460	COG2011	ABC-type metal ion transport system permease component
SMUL_RS02465	COG1464	Belongs to the NlpA lipoprotein family
SMUL_RS02480	COG1522	sequence-specific DNA binding
SMUL_RS02485	COG0697	spore germination
SMUL_RS02500	COG0534	Mate efflux family protein
SMUL_RS02515	COG0745	RESPONSE REGULATOR receiver
SMUL_RS02530	COG0840	transmembrane signaling receptor activity
SMUL_RS02535	COG0840	transmembrane signaling receptor activity
SMUL_RS02545	COG1034	ATP synthesis coupled electron transport
SMUL_RS02550	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMUL_RS02555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS02560	COG0839	Belongs to the complex I subunit 6 family
SMUL_RS02565	COG0713	ATP synthesis coupled electron transport
SMUL_RS02570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMUL_RS02575	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS02580	COG1007	ATP synthesis coupled electron transport
SMUL_RS02600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS02600	COG0649	NAD binding
SMUL_RS02605	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS02610	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS02625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMUL_RS02645	COG0357	Ribosomal RNA small subunit methyltransferase G
SMUL_RS02650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMUL_RS02655	COG1970	mechanosensitive ion channel activity
SMUL_RS02665	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMUL_RS02670	COG0113	porphobilinogen synthase activity
SMUL_RS02675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMUL_RS02685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMUL_RS02690	COG0247	lactate metabolic process
SMUL_RS02715	COG2026	Addiction module toxin, RelE StbE family
SMUL_RS02725	COG2814	Major facilitator Superfamily
SMUL_RS02730	COG3012	SEC-C Motif Domain Protein
SMUL_RS02745	COG3706	GGDEF domain
SMUL_RS02750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMUL_RS02760	COG1053	succinate dehydrogenase
SMUL_RS02765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SMUL_RS02775	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SMUL_RS02780	COG0628	permease
SMUL_RS02785	COG2255	four-way junction helicase activity
SMUL_RS02790	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMUL_RS02800	COG0159	tryptophan synthase activity
SMUL_RS02820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMUL_RS02825	COG1136	(ABC) transporter
SMUL_RS02830	COG1684	flagellar biosynthetic protein fliR
SMUL_RS02840	COG0194	GDP metabolic process
SMUL_RS02845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMUL_RS02850	COG0018	arginyl-trna synthetase
SMUL_RS02860	COG3706	GGDEF domain
SMUL_RS02875	COG0735	belongs to the Fur family
SMUL_RS02885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMUL_RS02890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMUL_RS02900	COG0149	triose-phosphate isomerase activity
SMUL_RS02905	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SMUL_RS02915	COG0195	Participates in both transcription termination and antitermination
SMUL_RS02950	COG0037	tRNA processing
SMUL_RS02955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMUL_RS02960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SMUL_RS02965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMUL_RS02990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMUL_RS02995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SMUL_RS03000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMUL_RS03010	COG1151	hydroxylamine reductase activity
SMUL_RS03040	COG2326	polyphosphate kinase activity
SMUL_RS03065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMUL_RS03075	COG1981	membrane
SMUL_RS03080	COG0513	Belongs to the DEAD box helicase family
SMUL_RS03085	COG2610	gluconate transmembrane transporter activity
SMUL_RS03090	COG1944	ATP diphosphatase activity
SMUL_RS03115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SMUL_RS03130	COG2361	Protein of unknown function DUF86
SMUL_RS03200	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMUL_RS03220	COG1333	cytochrome c biogenesis protein
SMUL_RS03220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMUL_RS03260	COG1058	Belongs to the CinA family
SMUL_RS03260	COG1546	Belongs to the CinA family
SMUL_RS03265	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMUL_RS03275	COG0517	IMP dehydrogenase activity
SMUL_RS03275	COG0516	GMP reductase activity
SMUL_RS03280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SMUL_RS03295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMUL_RS03300	COG0436	Aminotransferase
SMUL_RS03315	COG1193	negative regulation of DNA recombination
SMUL_RS03320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMUL_RS03325	COG0251	oxidation-reduction process
SMUL_RS03330	COG0579	oxidoreductase
SMUL_RS03345	COG0454	-acetyltransferase
SMUL_RS03345	COG0456	acetyltransferase
SMUL_RS03350	COG0793	Belongs to the peptidase S41A family
SMUL_RS03350	COG3409	Peptidoglycan-binding domain 1 protein
SMUL_RS03360	COG0469	pyruvate kinase activity
SMUL_RS03365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMUL_RS03370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMUL_RS03375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMUL_RS03380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMUL_RS03385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMUL_RS03395	COG1192	Involved in chromosome partitioning
SMUL_RS03400	COG1475	DNA binding
SMUL_RS03410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMUL_RS03415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMUL_RS03425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMUL_RS03440	COG0811	peptide transport
SMUL_RS03445	COG0848	biopolymer transport protein
SMUL_RS03455	COG0823	Involved in the tonB-independent uptake of proteins
SMUL_RS03470	COG1047	Peptidyl-prolyl cis-trans
SMUL_RS03480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMUL_RS03485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SMUL_RS03490	COG0037	tRNA processing
SMUL_RS03500	COG0070	glutamate synthase
SMUL_RS03500	COG0069	glutamate synthase activity
SMUL_RS03500	COG0067	glutamate synthase
SMUL_RS03505	COG0493	'glutamate synthase
SMUL_RS03515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SMUL_RS03520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMUL_RS03525	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SMUL_RS03535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMUL_RS03555	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SMUL_RS03555	COG1776	CheC inhibitor of MCP methylation
SMUL_RS03570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMUL_RS03580	COG0748	coenzyme F420 binding
SMUL_RS03615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SMUL_RS03630	COG1113	amino acid transport
SMUL_RS03635	COG0730	response to heat
SMUL_RS03640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMUL_RS03645	COG1301	dicarboxylic acid transport
SMUL_RS03650	COG1301	dicarboxylic acid transport
SMUL_RS03660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMUL_RS03660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMUL_RS03665	COG1971	Probably functions as a manganese efflux pump
SMUL_RS03675	COG0484	heat shock protein binding
SMUL_RS03700	COG1271	oxidase subunit
SMUL_RS03705	COG1294	oxidase, subunit
SMUL_RS03710	COG0745	RESPONSE REGULATOR receiver
SMUL_RS03715	COG0642	Histidine kinase
SMUL_RS03720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMUL_RS03730	COG0840	transmembrane signaling receptor activity
SMUL_RS03735	COG0318	PFAM AMP-dependent synthetase and ligase
SMUL_RS03740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMUL_RS03745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMUL_RS03760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMUL_RS03765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMUL_RS03790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMUL_RS03825	COG0784	Response regulator, receiver
SMUL_RS03825	COG2205	protein histidine kinase activity
SMUL_RS03825	COG5002	protein histidine kinase activity
SMUL_RS03840	COG0322	excinuclease ABC activity
SMUL_RS03850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SMUL_RS03855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SMUL_RS03860	COG0519	Catalyzes the synthesis of GMP from XMP
SMUL_RS03860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMUL_RS03890	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMUL_RS03905	COG2205	protein histidine kinase activity
SMUL_RS03905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUL_RS03910	COG0745	RESPONSE REGULATOR receiver
SMUL_RS03935	COG0511	ligase activity, forming carbon-carbon bonds
SMUL_RS03945	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMUL_RS03950	COG0165	Argininosuccinate lyase
SMUL_RS03955	COG0537	adenosine 5'-monophosphoramidase activity
SMUL_RS03960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMUL_RS03965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUL_RS03965	COG0072	phenylalanine-tRNA ligase activity
SMUL_RS03970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMUL_RS03975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SMUL_RS03980	COG0539	negative regulation of cytoplasmic translation
SMUL_RS03980	COG1185	polyribonucleotide nucleotidyltransferase activity
SMUL_RS03990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMUL_RS04000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMUL_RS04010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMUL_RS04020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMUL_RS04035	COG0840	transmembrane signaling receptor activity
SMUL_RS04055	COG2081	HI0933 family
SMUL_RS04075	COG1981	membrane
SMUL_RS04100	COG2199	diguanylate cyclase activity
SMUL_RS04100	COG2200	EAL domain
SMUL_RS04100	COG3287	FIST C domain
SMUL_RS04105	COG1902	pentaerythritol trinitrate reductase activity
SMUL_RS04125	COG0840	transmembrane signaling receptor activity
SMUL_RS04130	COG0840	transmembrane signaling receptor activity
SMUL_RS04130	COG0840	transmembrane signaling receptor activity
SMUL_RS04140	COG0587	DNA-directed DNA polymerase activity
SMUL_RS04145	COG0517	IMP dehydrogenase activity
SMUL_RS04160	COG0642	Histidine kinase
SMUL_RS04170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMUL_RS04175	COG0569	domain protein
SMUL_RS04190	COG0772	Belongs to the SEDS family
SMUL_RS04195	COG0564	pseudouridine synthase activity
SMUL_RS04205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMUL_RS04210	COG1136	(ABC) transporter
SMUL_RS04225	COG0528	UMP kinase activity
SMUL_RS04230	COG1758	RNA polymerase activity
SMUL_RS04240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMUL_RS04250	COG0860	N-Acetylmuramoyl-L-alanine amidase
SMUL_RS04260	COG0563	adenylate kinase activity
SMUL_RS04265	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMUL_RS04280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMUL_RS04285	COG0497	DNA recombination
SMUL_RS04290	COG1620	l-lactate permease
SMUL_RS04295	COG3706	GGDEF domain
SMUL_RS04300	COG0084	hydrolase, TatD family'
SMUL_RS04305	COG3942	CHAP domain
SMUL_RS04305	COG1388	LysM domain
SMUL_RS04310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMUL_RS04315	COG0131	Imidazoleglycerol-phosphate dehydratase
SMUL_RS04320	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SMUL_RS04335	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMUL_RS04350	COG0768	penicillin binding
SMUL_RS04370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUL_RS04370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUL_RS04380	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SMUL_RS04405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMUL_RS04410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMUL_RS04420	COG3005	denitrification pathway
SMUL_RS04430	COG1333	cytochrome c biogenesis protein
SMUL_RS04430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMUL_RS04450	COG3545	Serine hydrolase
SMUL_RS04465	COG1346	cytolysis
SMUL_RS04480	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
SMUL_RS04490	COG0398	Pfam SNARE associated Golgi protein
SMUL_RS04500	COG0398	Pfam SNARE associated Golgi protein
SMUL_RS04505	COG2226	methyltransferase
SMUL_RS04510	COG0697	spore germination
SMUL_RS04540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMUL_RS04545	COG4716	Myosin-crossreactive antigen
SMUL_RS04555	COG4585	Histidine kinase
SMUL_RS04575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SMUL_RS04590	COG1845	cytochrome c oxidase, subunit III
SMUL_RS04590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SMUL_RS04620	COG4804	nuclease activity
SMUL_RS04635	COG0243	molybdopterin cofactor binding
SMUL_RS04640	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS04645	COG0348	domain, Protein
SMUL_RS04650	COG3043	anaerobic respiration
SMUL_RS04655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_RS04655	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_RS04700	COG1595	DNA-templated transcription, initiation
SMUL_RS04715	COG0243	molybdopterin cofactor binding
SMUL_RS04730	COG0745	RESPONSE REGULATOR receiver
SMUL_RS04740	COG3852	Histidine kinase
SMUL_RS04745	COG2863	cytochrome
SMUL_RS04750	COG0723	plastoquinol--plastocyanin reductase activity
SMUL_RS04755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SMUL_RS04775	COG2199	diguanylate cyclase activity
SMUL_RS04775	COG3287	FIST C domain
SMUL_RS04775	COG2200	EAL domain
SMUL_RS04780	COG0688	phosphatidylethanolamine metabolic process
SMUL_RS04785	COG0513	Belongs to the DEAD box helicase family
SMUL_RS04800	COG2964	Protein conserved in bacteria
SMUL_RS04805	COG2084	Dehydrogenase
SMUL_RS04815	COG3383	formate dehydrogenase (NAD+) activity
SMUL_RS04820	COG3383	formate dehydrogenase (NAD+) activity
SMUL_RS04825	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS04835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMUL_RS04840	COG2258	MOSC domain
SMUL_RS04845	COG1280	lysine exporter protein (LysE YggA)
SMUL_RS04850	COG3437	response regulator, receiver
SMUL_RS04850	COG0784	Response regulator, receiver
SMUL_RS04865	COG0217	transcriptional regulatory protein
SMUL_RS04875	COG2358	TRAP transporter, solute receptor (TAXI family
SMUL_RS04890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMUL_RS04945	COG2801	Transposase and inactivated derivatives
SMUL_RS04950	COG2963	transposase activity
SMUL_RS04955	COG1696	Membrane protein involved in D-alanine export
SMUL_RS05005	COG1305	Transglutaminase-like
SMUL_RS05025	COG1305	Transglutaminase-like
SMUL_RS05035	COG2308	Evidence 4 Homologs of previously reported genes of
SMUL_RS05045	COG2966	Psort location CytoplasmicMembrane, score
SMUL_RS05050	COG3610	response to peptide
SMUL_RS05055	COG2703	oxygen carrier activity
SMUL_RS05060	COG2217	Heavy metal translocating P-type atpase
SMUL_RS05065	COG0640	Transcriptional regulator
SMUL_RS05070	COG1280	lysine exporter protein (LysE YggA)
SMUL_RS05080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMUL_RS05085	COG2169	Transcriptional regulator
SMUL_RS05085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMUL_RS05095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SMUL_RS05105	COG0840	transmembrane signaling receptor activity
SMUL_RS05105	COG3290	protein histidine kinase activity
SMUL_RS05115	COG0352	thiamine-phosphate diphosphorylase activity
SMUL_RS05130	COG1272	protein, Hemolysin III
SMUL_RS05145	COG0247	lactate metabolic process
SMUL_RS05155	COG1556	Lactate utilization protein
SMUL_RS05160	COG0697	spore germination
SMUL_RS05180	COG2176	DNA-directed DNA polymerase activity
SMUL_RS05205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMUL_RS05215	COG0501	Belongs to the peptidase M48B family
SMUL_RS05235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMUL_RS05240	COG2201	protein-glutamate methylesterase activity
SMUL_RS05245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMUL_RS05250	COG0586	Pfam SNARE associated Golgi protein
SMUL_RS05255	COG0133	tryptophan synthase activity
SMUL_RS05260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMUL_RS05270	COG0698	ribose 5-phosphate isomerase
SMUL_RS05275	COG1994	Peptidase M50
SMUL_RS05280	COG0681	Belongs to the peptidase S26 family
SMUL_RS05285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMUL_RS05400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SMUL_RS05415	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMUL_RS05420	COG0612	Peptidase, M16
SMUL_RS05425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMUL_RS05455	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SMUL_RS05460	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SMUL_RS05465	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMUL_RS05470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMUL_RS05475	COG0629	single-stranded DNA binding
SMUL_RS05480	COG0360	Binds together with S18 to 16S ribosomal RNA
SMUL_RS05485	COG1466	dna polymerase III delta subunit
SMUL_RS05490	COG0557	exoribonuclease II activity
SMUL_RS05500	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMUL_RS05505	COG2894	cell division
SMUL_RS05510	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SMUL_RS05520	COG0758	DNA mediated transformation
SMUL_RS05525	COG0730	response to heat
SMUL_RS05530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMUL_RS05545	COG1760	l-serine dehydratase
SMUL_RS05550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMUL_RS05555	COG2860	membrane
SMUL_RS05560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMUL_RS05575	COG0736	holo-[acyl-carrier-protein] synthase activity
SMUL_RS05580	COG1580	Controls the rotational direction of flagella during chemotaxis
SMUL_RS05585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SMUL_RS05590	COG0552	protein localization to endoplasmic reticulum
SMUL_RS05595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMUL_RS05605	COG1418	mRNA catabolic process
SMUL_RS05610	COG1132	(ABC) transporter
SMUL_RS05620	COG0586	Pfam SNARE associated Golgi protein
SMUL_RS05635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMUL_RS05650	COG0745	RESPONSE REGULATOR receiver
SMUL_RS05655	COG2204	response regulator
SMUL_RS05660	COG5001	Diguanylate cyclase
SMUL_RS05660	COG5002	protein histidine kinase activity
SMUL_RS05680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMUL_RS05720	COG1518	maintenance of DNA repeat elements
SMUL_RS05830	COG3328	transposase activity
SMUL_RS05850	COG1450	Type ii and iii secretion system protein
SMUL_RS05885	COG5002	protein histidine kinase activity
SMUL_RS05890	COG1408	metallophosphoesterase
SMUL_RS05895	COG2353	YceI-like domain
SMUL_RS05910	COG1136	(ABC) transporter
SMUL_RS05925	COG4456	Virulence-associated protein
SMUL_RS05950	COG3328	transposase activity
SMUL_RS05980	COG0242	peptide deformylase activity
SMUL_RS05985	COG0824	Thioesterase
SMUL_RS05995	COG1573	uracil-dna glycosylase
SMUL_RS06010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMUL_RS06025	COG0745	RESPONSE REGULATOR receiver
SMUL_RS06030	COG2199	diguanylate cyclase activity
SMUL_RS06030	COG2200	EAL domain
SMUL_RS06030	COG3287	FIST C domain
SMUL_RS06040	COG0745	RESPONSE REGULATOR receiver
SMUL_RS06045	COG0426	domain, Protein
SMUL_RS06060	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMUL_RS06065	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMUL_RS06070	COG2040	homocysteine
SMUL_RS06075	COG1012	belongs to the aldehyde dehydrogenase family
SMUL_RS06090	COG3437	response regulator, receiver
SMUL_RS06090	COG0784	Response regulator, receiver
SMUL_RS06100	COG3437	response regulator, receiver
SMUL_RS06110	COG1433	Dinitrogenase iron-molybdenum cofactor
SMUL_RS06140	COG0633	Ferredoxin
SMUL_RS06145	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMUL_RS06180	COG2026	Addiction module toxin, RelE StbE family
SMUL_RS06185	COG3645	SOS response
SMUL_RS06240	COG1451	nucleotide metabolic process
SMUL_RS06290	COG0697	spore germination
SMUL_RS06300	COG3706	GGDEF domain
SMUL_RS06305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMUL_RS06350	COG0243	molybdopterin cofactor binding
SMUL_RS06365	COG0747	negative chemotaxis
SMUL_RS06370	COG0745	RESPONSE REGULATOR receiver
SMUL_RS06385	COG1276	copper resistance
SMUL_RS06390	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SMUL_RS06400	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMUL_RS06405	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMUL_RS06420	COG0745	RESPONSE REGULATOR receiver
SMUL_RS06430	COG3153	acetyltransferase
SMUL_RS06430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMUL_RS06480	COG0493	'glutamate synthase
SMUL_RS06485	COG0375	protein maturation
SMUL_RS06490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_RS06500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS06510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMUL_RS06525	COG2814	Major facilitator Superfamily
SMUL_RS06555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMUL_RS06565	COG1131	(ABC) transporter
SMUL_RS06570	COG0842	Transport permease protein
SMUL_RS06575	COG4456	Virulence-associated protein
SMUL_RS06600	COG0667	Aldo Keto reductase
SMUL_RS06605	COG1053	succinate dehydrogenase
SMUL_RS06640	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SMUL_RS06645	COG0585	pseudouridine synthase activity
SMUL_RS06650	COG0569	domain protein
SMUL_RS06650	COG0475	glutathione-regulated potassium exporter activity
SMUL_RS06670	COG2203	Gaf domain
SMUL_RS06670	COG2199	diguanylate cyclase activity
SMUL_RS06675	COG0352	thiamine-phosphate diphosphorylase activity
SMUL_RS06675	COG0351	phosphomethylpyrimidine kinase
SMUL_RS06685	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SMUL_RS06695	COG0428	transporter
SMUL_RS06705	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMUL_RS06715	COG0840	transmembrane signaling receptor activity
SMUL_RS06720	COG1234	tRNA 3'-trailer cleavage
SMUL_RS06730	COG0488	(ABC) transporter
SMUL_RS06735	COG1360	Flagellar Motor Protein
SMUL_RS06740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SMUL_RS06745	COG1309	transcriptional regulator
SMUL_RS06775	COG0778	Nitroreductase
SMUL_RS06780	COG0778	Nitroreductase
SMUL_RS06785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SMUL_RS06795	COG0415	Belongs to the DNA photolyase family
SMUL_RS06805	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SMUL_RS06830	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SMUL_RS06845	COG4145	pantothenate transmembrane transporter activity
SMUL_RS06860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SMUL_RS06875	COG0742	ribosomal rna small subunit methyltransferase
SMUL_RS06880	COG1706	bacterial-type flagellum-dependent cell motility
SMUL_RS06885	COG3951	Flagellar rod assembly protein muramidase FlgJ
SMUL_RS06905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMUL_RS06915	COG0659	secondary active sulfate transmembrane transporter activity
SMUL_RS06920	COG1942	4-Oxalocrotonate Tautomerase
SMUL_RS06925	COG0356	it plays a direct role in the translocation of protons across the membrane
SMUL_RS06945	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMUL_RS06955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SMUL_RS06960	COG0101	tRNA pseudouridine synthase activity
SMUL_RS06970	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SMUL_RS06980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMUL_RS06985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMUL_RS06990	COG1338	Plays a role in the flagellum-specific transport system
SMUL_RS06995	COG0676	glucose-6-phosphate 1-epimerase activity
SMUL_RS07000	COG1733	regulation of RNA biosynthetic process
SMUL_RS07005	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMUL_RS07015	COG4269	membrane
SMUL_RS07030	COG3174	membrane
SMUL_RS07035	COG1032	radical SAM domain protein
SMUL_RS07040	COG0166	Belongs to the GPI family
SMUL_RS07065	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SMUL_RS07070	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SMUL_RS07075	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
SMUL_RS07080	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SMUL_RS07085	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMUL_RS07090	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMUL_RS07100	COG4774	siderophore transport
SMUL_RS07120	COG0298	carbon dioxide binding
SMUL_RS07125	COG0409	Hydrogenase expression formation protein
SMUL_RS07130	COG0309	Hydrogenase expression formation protein (HypE)
SMUL_RS07140	COG1247	-acetyltransferase
SMUL_RS07145	COG0546	phosphoglycolate phosphatase activity
SMUL_RS07165	COG0039	L-malate dehydrogenase activity
SMUL_RS07185	COG0471	metal ion transport
SMUL_RS07195	COG0247	lactate metabolic process
SMUL_RS07200	COG0277	FAD linked oxidase domain protein
SMUL_RS07205	COG0045	succinate-CoA ligase (ADP-forming) activity
SMUL_RS07210	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SMUL_RS07220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMUL_RS07220	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMUL_RS07225	COG3962	Belongs to the TPP enzyme family
SMUL_RS07250	COG0114	fumarate hydratase activity
SMUL_RS07265	COG2095	MarC family integral membrane protein
SMUL_RS07285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMUL_RS07290	COG0750	zinc metalloprotease
SMUL_RS07295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMUL_RS07300	COG1028	Short-chain dehydrogenase reductase Sdr
SMUL_RS07305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMUL_RS07315	COG0167	dihydroorotate dehydrogenase activity
SMUL_RS07320	COG1132	(ABC) transporter
SMUL_RS07325	COG0215	cysteine-tRNA ligase activity
SMUL_RS07330	COG0728	peptidoglycan biosynthetic process
SMUL_RS07340	COG0632	four-way junction helicase activity
SMUL_RS07345	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMUL_RS07365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMUL_RS07370	COG0857	belongs to the CobB CobQ family
SMUL_RS07370	COG0280	phosphate acetyltransferase
SMUL_RS07375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMUL_RS07400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMUL_RS07440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SMUL_RS07445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SMUL_RS07460	COG0137	argininosuccinate synthase activity
SMUL_RS07465	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMUL_RS07470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMUL_RS07475	COG0802	atpase or kinase
SMUL_RS07480	COG1137	ATPase activity
SMUL_RS07485	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SMUL_RS07505	COG0419	ATPase involved in DNA repair
SMUL_RS07510	COG1196	nuclear chromosome segregation
SMUL_RS07580	COG1053	succinate dehydrogenase
SMUL_RS07645	COG0745	RESPONSE REGULATOR receiver
SMUL_RS07665	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SMUL_RS07675	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SMUL_RS07685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SMUL_RS07695	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SMUL_RS07710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMUL_RS07715	COG1120	ATPase activity
SMUL_RS07730	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SMUL_RS07775	COG1132	(ABC) transporter
SMUL_RS07780	COG1797	cobyrinic acid a,c-diamide synthase activity
SMUL_RS07790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SMUL_RS07790	COG1648	precorrin-2 dehydrogenase activity
SMUL_RS07795	COG1309	transcriptional regulator
SMUL_RS07920	COG0582	viral genome integration into host DNA
SMUL_RS07930	COG0776	regulation of translation
SMUL_RS07935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMUL_RS07940	COG1674	ftsk spoiiie
SMUL_RS07940	COG1196	nuclear chromosome segregation
SMUL_RS07945	COG1049	propionate catabolic process, 2-methylcitrate cycle
SMUL_RS07950	COG1047	Peptidyl-prolyl cis-trans
SMUL_RS07955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMUL_RS07955	COG0574	Belongs to the PEP-utilizing enzyme family
SMUL_RS07960	COG2814	Major facilitator Superfamily
SMUL_RS07980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMUL_RS07990	COG1832	CoA-binding protein
SMUL_RS07995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMUL_RS08005	COG1126	abc transporter atp-binding protein
SMUL_RS08010	COG0765	amino acid transport
SMUL_RS08015	COG4597	amino acid ABC transporter
SMUL_RS08020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUL_RS08025	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SMUL_RS08040	COG0586	Pfam SNARE associated Golgi protein
SMUL_RS08055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMUL_RS08070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMUL_RS08075	COG0727	PFAM Uncharacterised protein family (UPF0153)
SMUL_RS08085	COG0134	indole-3-glycerol-phosphate synthase activity
SMUL_RS08095	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SMUL_RS08105	COG0310	cobalt ion transport
SMUL_RS08125	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SMUL_RS08130	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SMUL_RS08145	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMUL_RS08155	COG0248	Ppx GppA phosphatase
SMUL_RS08160	COG0028	Belongs to the TPP enzyme family
SMUL_RS08170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SMUL_RS08180	COG0493	'glutamate synthase
SMUL_RS08185	COG0436	Aminotransferase
SMUL_RS08190	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
SMUL_RS08220	COG1045	serine acetyltransferase
SMUL_RS08225	COG1166	arginine decarboxylase activity
SMUL_RS08230	COG0124	histidyl-tRNA synthetase
SMUL_RS08240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMUL_RS08245	COG0163	prenyltransferase activity
SMUL_RS08260	COG0840	transmembrane signaling receptor activity
SMUL_RS08265	COG0303	'Molybdopterin
SMUL_RS08270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMUL_RS08300	COG0489	protein tyrosine kinase activity
SMUL_RS08310	COG1342	Belongs to the UPF0251 family
SMUL_RS08315	COG1691	(AIR) carboxylase
SMUL_RS08320	COG1606	tRNA processing
SMUL_RS08325	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SMUL_RS08330	COG3875	lactate racemase activity
SMUL_RS08335	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SMUL_RS08335	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SMUL_RS08345	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SMUL_RS08380	COG0582	viral genome integration into host DNA
SMUL_RS08385	COG0343	queuine tRNA-ribosyltransferase activity
SMUL_RS08395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMUL_RS08405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMUL_RS08410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMUL_RS08430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SMUL_RS08445	COG2378	regulation of single-species biofilm formation
SMUL_RS08450	COG1187	pseudouridine synthase activity
SMUL_RS08455	COG0028	Belongs to the TPP enzyme family
SMUL_RS08465	COG2066	Belongs to the glutaminase family
SMUL_RS08480	COG1981	membrane
SMUL_RS08485	COG1309	transcriptional regulator
SMUL_RS08515	COG0840	transmembrane signaling receptor activity
SMUL_RS08620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMUL_RS08640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMUL_RS08755	COG3328	transposase activity
SMUL_RS08810	COG0582	viral genome integration into host DNA
SMUL_RS08835	COG0776	regulation of translation
SMUL_RS09035	COG3344	reverse transcriptase
SMUL_RS09115	COG0629	single-stranded DNA binding
SMUL_RS09330	COG4774	siderophore transport
SMUL_RS09445	COG1592	Rubrerythrin
SMUL_RS09455	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMUL_RS09460	COG0181	hydroxymethylbilane synthase activity
SMUL_RS09475	COG0442	prolyl-tRNA aminoacylation
SMUL_RS09480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SMUL_RS09485	COG0142	geranyltranstransferase activity
SMUL_RS09505	COG1959	2 iron, 2 sulfur cluster binding
SMUL_RS09515	COG3706	GGDEF domain
SMUL_RS09520	COG0525	valine-tRNA ligase activity
SMUL_RS09525	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SMUL_RS09530	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMUL_RS09540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMUL_RS09555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMUL_RS09560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMUL_RS09570	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMUL_RS09580	COG0500	methyltransferase
SMUL_RS09595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMUL_RS09600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMUL_RS09605	COG1663	tetraacyldisaccharide 4'-kinase activity
SMUL_RS09610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMUL_RS09615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMUL_RS09620	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SMUL_RS09635	COG4232	protein-disulfide reductase activity
SMUL_RS09645	COG0443	Heat shock 70 kDa protein
SMUL_RS09650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMUL_RS09655	COG1420	regulation of RNA biosynthetic process
SMUL_RS09675	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SMUL_RS09680	COG2404	hydrolase activity, acting on ester bonds
SMUL_RS09690	COG2226	methyltransferase
SMUL_RS09700	COG0196	riboflavin kinase activity
SMUL_RS09705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMUL_RS09710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMUL_RS09715	COG0730	response to heat
SMUL_RS09725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SMUL_RS09740	COG0527	aspartate kinase activity
SMUL_RS09745	COG0494	nUDIX hydrolase
SMUL_RS09750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMUL_RS09760	COG0789	Transcriptional regulator
SMUL_RS09765	COG0484	heat shock protein binding
SMUL_RS09770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMUL_RS09775	COG0745	RESPONSE REGULATOR receiver
SMUL_RS09780	COG0642	Histidine kinase
SMUL_RS09795	COG0653	protein targeting
SMUL_RS09810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SMUL_RS09815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMUL_RS09825	COG0706	membrane insertase activity
SMUL_RS09830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMUL_RS09835	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMUL_RS09850	COG4865	methylaspartate mutase activity
SMUL_RS09970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SMUL_RS09985	COG0542	response to heat
SMUL_RS09990	COG0793	Belongs to the peptidase S41A family
SMUL_RS09995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMUL_RS10000	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMUL_RS10005	COG0047	phosphoribosylformylglycinamidine synthase activity
SMUL_RS10015	COG0204	Acyl-transferase
SMUL_RS10020	COG0326	Molecular chaperone. Has ATPase activity
SMUL_RS10025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMUL_RS10050	COG1331	Highly conserved protein containing a thioredoxin domain
SMUL_RS10055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMUL_RS10095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMUL_RS10120	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMUL_RS10130	COG2608	mercury ion transmembrane transporter activity
SMUL_RS10135	COG2217	Heavy metal translocating P-type atpase
SMUL_RS10155	COG0275	rRNA processing
SMUL_RS10165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMUL_RS10170	COG0849	cell division
SMUL_RS10175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SMUL_RS10185	COG2890	protein-(glutamine-N5) methyltransferase activity
SMUL_RS10190	COG0501	Belongs to the peptidase M48B family
SMUL_RS10200	COG0488	(ABC) transporter
SMUL_RS10205	COG0840	transmembrane signaling receptor activity
SMUL_RS10215	COG2151	metal-sulfur cluster biosynthetic enzyme
SMUL_RS10230	COG0138	bifunctional purine biosynthesis protein purh
SMUL_RS10235	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SMUL_RS10245	COG1607	acyl-coa hydrolase
SMUL_RS10250	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SMUL_RS10255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMUL_RS10275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMUL_RS10285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SMUL_RS10290	COG0805	protein transport
SMUL_RS10295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMUL_RS10325	COG3328	transposase activity
SMUL_RS10340	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SMUL_RS10345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUL_RS10350	COG0765	amino acid transport
SMUL_RS10365	COG3437	response regulator, receiver
SMUL_RS10380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMUL_RS10385	COG1022	Amp-dependent synthetase and ligase
SMUL_RS10395	COG4206	TonB-dependent receptor
SMUL_RS10400	COG2205	protein histidine kinase activity
SMUL_RS10405	COG0745	RESPONSE REGULATOR receiver
SMUL_RS10410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMUL_RS10415	COG0569	domain protein
SMUL_RS10420	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMUL_RS10435	COG2068	MobA-Related Protein
SMUL_RS10440	COG3608	succinylglutamate desuccinylase aspartoacylase
SMUL_RS10440	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMUL_RS10445	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SMUL_RS10450	COG0535	radical SAM domain protein
SMUL_RS10480	COG2205	protein histidine kinase activity
SMUL_RS10485	COG0745	RESPONSE REGULATOR receiver
SMUL_RS10495	COG3038	cytochrome b561
SMUL_RS10505	COG0642	Histidine kinase
SMUL_RS10510	COG0745	RESPONSE REGULATOR receiver
SMUL_RS10520	COG1230	cation diffusion facilitator family transporter
SMUL_RS10540	COG4774	siderophore transport
SMUL_RS10550	COG0668	transmembrane transport
SMUL_RS10585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SMUL_RS10590	COG4263	nitrous-oxide reductase activity
SMUL_RS10605	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SMUL_RS10615	COG1410	methionine synthase
SMUL_RS10615	COG0646	methionine synthase
SMUL_RS10630	COG0840	transmembrane signaling receptor activity
SMUL_RS10635	COG1280	lysine exporter protein (LysE YggA)
SMUL_RS10650	COG0004	ammonium transporteR
SMUL_RS10655	COG0347	Belongs to the P(II) protein family
SMUL_RS10665	COG1401	restriction endodeoxyribonuclease activity
SMUL_RS10700	COG0288	reversible hydration of carbon dioxide
SMUL_RS10705	COG3123	guanosine phosphorylase activity
SMUL_RS10715	COG2081	HI0933 family
SMUL_RS10725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SMUL_RS10730	COG0788	formyltetrahydrofolate deformylase activity
SMUL_RS10750	COG0473	3-isopropylmalate dehydrogenase activity
SMUL_RS10755	COG0066	3-isopropylmalate dehydratase activity
SMUL_RS10760	COG1119	ATPase activity
SMUL_RS10780	COG0708	Exodeoxyribonuclease III
SMUL_RS10795	COG0840	transmembrane signaling receptor activity
SMUL_RS10805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMUL_RS10810	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SMUL_RS10815	COG3005	denitrification pathway
SMUL_RS10820	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SMUL_RS10825	COG0840	transmembrane signaling receptor activity
SMUL_RS10835	COG0745	RESPONSE REGULATOR receiver
SMUL_RS10855	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SMUL_RS10875	COG4895	conserved protein (DUF2196)
SMUL_RS10895	COG0513	Belongs to the DEAD box helicase family
SMUL_RS10905	COG5001	Diguanylate cyclase
SMUL_RS10910	COG0642	Histidine kinase
SMUL_RS10915	COG0745	RESPONSE REGULATOR receiver
SMUL_RS10955	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SMUL_RS10960	COG0372	Belongs to the citrate synthase family
SMUL_RS10965	COG2079	MmgE PrpD family protein
SMUL_RS10975	COG2824	Alkylphosphonate utilization operon protein PhnA
SMUL_RS10985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SMUL_RS10990	COG4786	Flagellar basal body rod
SMUL_RS10995	COG4786	Flagellar basal body rod
SMUL_RS11000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMUL_RS11010	COG1733	regulation of RNA biosynthetic process
SMUL_RS11025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SMUL_RS11030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMUL_RS11035	COG3162	membrane
SMUL_RS11040	COG0745	RESPONSE REGULATOR receiver
SMUL_RS11050	COG2957	Belongs to the agmatine deiminase family
SMUL_RS11060	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMUL_RS11065	COG1918	ferrous iron import across plasma membrane
SMUL_RS11090	COG3585	molybdate ion transport
SMUL_RS11100	COG0598	Magnesium transport protein CorA
SMUL_RS11105	COG0739	heme binding
SMUL_RS11115	COG0277	FAD linked oxidase domain protein
SMUL_RS11120	COG1295	ribonuclease BN
SMUL_RS11130	COG0305	Participates in initiation and elongation during chromosome replication
SMUL_RS11130	COG0305	Participates in initiation and elongation during chromosome replication
SMUL_RS11135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SMUL_RS11140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMUL_RS11145	COG2165	general secretion pathway protein
SMUL_RS11165	COG0556	nucleotide-excision repair
SMUL_RS11175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SMUL_RS11180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SMUL_RS11185	COG2176	DNA-directed DNA polymerase activity
SMUL_RS11190	COG0135	phosphoribosylanthranilate isomerase activity
SMUL_RS11195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SMUL_RS11205	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMUL_RS11220	COG1692	metallophosphoesterase
SMUL_RS11225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMUL_RS11235	COG0739	heme binding
SMUL_RS11240	COG0285	dihydrofolate synthase activity
SMUL_RS11255	COG0495	leucyl-tRNA aminoacylation
SMUL_RS11260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMUL_RS11265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SMUL_RS11270	COG1862	Preprotein translocase
SMUL_RS11275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SMUL_RS11280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMUL_RS11290	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
SMUL_RS11295	COG0542	response to heat
SMUL_RS11300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SMUL_RS11310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMUL_RS11315	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMUL_RS11320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SMUL_RS11325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMUL_RS11330	COG0210	DNA helicase
SMUL_RS11360	COG0540	Belongs to the ATCase OTCase family
SMUL_RS11370	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SMUL_RS11405	COG0336	Belongs to the RNA methyltransferase TrmD family
SMUL_RS11420	COG0228	four-way junction DNA binding
SMUL_RS11425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMUL_RS11430	COG0564	pseudouridine synthase activity
SMUL_RS11435	COG1519	Transferase
SMUL_RS11445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SMUL_RS11450	COG0752	glycyl-tRNA synthetase alpha subunit
SMUL_RS11460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMUL_RS11465	COG0826	peptidase U32
SMUL_RS11475	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMUL_RS11480	COG0174	glutamine synthetase
SMUL_RS11490	COG0444	Belongs to the ABC transporter superfamily
SMUL_RS11495	COG0156	8-amino-7-oxononanoate synthase activity
SMUL_RS11500	COG0424	maF-like protein
SMUL_RS11510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMUL_RS11525	COG5002	protein histidine kinase activity
SMUL_RS11530	COG0243	molybdopterin cofactor binding
SMUL_RS11535	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS11540	COG3302	dmso reductase anchor subunit
SMUL_RS11560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMUL_RS11575	COG1558	bacterial-type flagellum-dependent cell motility
SMUL_RS11580	COG1815	bacterial-type flagellum-dependent cell motility
SMUL_RS11585	COG0772	Belongs to the SEDS family
SMUL_RS11590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMUL_RS11605	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMUL_RS11615	COG0697	spore germination
SMUL_RS11655	COG0512	Glutamine amidotransferase of anthranilate synthase
SMUL_RS11660	COG2814	Major facilitator Superfamily
SMUL_RS11670	COG0640	Transcriptional regulator
SMUL_RS11700	COG2301	Belongs to the HpcH HpaI aldolase family
SMUL_RS11710	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SMUL_RS11715	COG3180	Ammonia monooxygenase
SMUL_RS11725	COG3290	protein histidine kinase activity
SMUL_RS11730	COG4565	transcriptional regulatory protein
SMUL_RS11755	COG3437	response regulator, receiver
SMUL_RS11760	COG2814	Major facilitator Superfamily
SMUL_RS11770	COG2252	PERMEase
SMUL_RS11775	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SMUL_RS11790	COG0133	tryptophan synthase activity
SMUL_RS11805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMUL_RS11810	COG3706	GGDEF domain
SMUL_RS11840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMUL_RS11860	COG0488	(ABC) transporter
SMUL_RS11870	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_RS11875	COG0651	ATP synthesis coupled electron transport
SMUL_RS11880	COG0650	Formate hydrogenlyase subunit 4
SMUL_RS11885	COG4237	Hydrogenase 4 membrane
SMUL_RS11890	COG0651	ATP synthesis coupled electron transport
SMUL_RS11895	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SMUL_RS11895	COG3261	NADH dehydrogenase
SMUL_RS11905	COG3260	NADH ubiquinone oxidoreductase 20
SMUL_RS11930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMUL_RS11940	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMUL_RS11960	COG2171	N-acyltransferase activity
SMUL_RS11965	COG0489	protein tyrosine kinase activity
SMUL_RS11970	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SMUL_RS11970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SMUL_RS11980	COG2046	Belongs to the sulfate adenylyltransferase family
SMUL_RS11995	COG2353	YceI-like domain
SMUL_RS12000	COG1739	Uncharacterized protein family UPF0029
SMUL_RS12005	COG0157	Belongs to the NadC ModD family
SMUL_RS12010	COG4208	sulfate ABC transporter
SMUL_RS12020	COG3842	ATPase activity
SMUL_RS12045	COG1686	Belongs to the peptidase S11 family
SMUL_RS12050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMUL_RS12055	COG0577	efflux transmembrane transporter activity
SMUL_RS12055	COG1136	(ABC) transporter
SMUL_RS12060	COG1136	(ABC) transporter
SMUL_RS12060	COG0577	efflux transmembrane transporter activity
SMUL_RS12065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMUL_RS12085	COG0668	transmembrane transport
SMUL_RS12160	COG0284	orotidine-5'-phosphate decarboxylase activity
SMUL_RS12165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMUL_RS12170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMUL_RS12185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SMUL_RS12190	COG0697	spore germination
SMUL_RS12195	COG0668	transmembrane transport
SMUL_RS12200	COG1160	GTP binding
SMUL_RS12215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMUL_RS12225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SMUL_RS12230	COG1183	phosphatidylcholine synthase activity
SMUL_RS12240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMUL_RS12245	COG2264	protein methyltransferase activity
SMUL_RS12250	COG0745	RESPONSE REGULATOR receiver
SMUL_RS12255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMUL_RS12260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMUL_RS12275	COG1086	Polysaccharide biosynthesis protein
SMUL_RS12280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMUL_RS12295	COG0438	transferase activity, transferring glycosyl groups
SMUL_RS12300	COG0110	maltose O-acetyltransferase activity
SMUL_RS12315	COG0110	maltose O-acetyltransferase activity
SMUL_RS12335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMUL_RS12345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMUL_RS12350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMUL_RS12360	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SMUL_RS12375	COG1793	dna ligase
SMUL_RS12385	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMUL_RS12390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMUL_RS12435	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SMUL_RS12440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SMUL_RS12440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SMUL_RS12445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMUL_RS12465	COG2608	mercury ion transmembrane transporter activity
SMUL_RS12465	COG2217	Heavy metal translocating P-type atpase
SMUL_RS12470	COG5002	protein histidine kinase activity
SMUL_RS12470	COG5001	Diguanylate cyclase
SMUL_RS12475	COG0697	spore germination
SMUL_RS12485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMUL_RS12495	COG1496	oxidoreductase activity
SMUL_RS12510	COG1984	allophanate hydrolase subunit 2
SMUL_RS12520	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SMUL_RS12540	COG2201	protein-glutamate methylesterase activity
SMUL_RS12550	COG0445	tRNA wobble uridine modification
SMUL_RS12555	COG0723	plastoquinol--plastocyanin reductase activity
SMUL_RS12575	COG0825	malonyl-CoA metabolic process
SMUL_RS12580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMUL_RS12585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMUL_RS12595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SMUL_RS12600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMUL_RS12605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMUL_RS12615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SMUL_RS12635	COG0300	oxidoreductase activity
SMUL_RS12640	COG0277	FAD linked oxidase domain protein
SMUL_RS12650	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMUL_RS12655	COG2801	Transposase and inactivated derivatives
SMUL_RS12745	COG1134	teichoic acid transport
SMUL_RS12760	COG1682	transport, permease protein
SMUL_RS12765	COG1088	dTDP-glucose 4,6-dehydratase activity
SMUL_RS12780	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMUL_RS12785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMUL_RS12810	COG0745	RESPONSE REGULATOR receiver
SMUL_RS12815	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SMUL_RS12830	COG0390	transport system, permease component
SMUL_RS12835	COG0439	Biotin carboxylase
SMUL_RS12850	COG0306	phosphate transporter
SMUL_RS12855	COG0513	Belongs to the DEAD box helicase family
SMUL_RS12860	COG1671	Belongs to the UPF0178 family
SMUL_RS12870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMUL_RS12880	COG0573	inorganic phosphate transmembrane transporter activity
SMUL_RS12885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMUL_RS12890	COG0840	transmembrane signaling receptor activity
SMUL_RS12890	COG3290	protein histidine kinase activity
SMUL_RS12895	COG3384	dioxygenase
SMUL_RS12900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMUL_RS12905	COG0471	metal ion transport
SMUL_RS12910	COG0840	transmembrane signaling receptor activity
SMUL_RS12935	COG0745	RESPONSE REGULATOR receiver
SMUL_RS12945	COG1607	acyl-coa hydrolase
SMUL_RS12975	COG1733	regulation of RNA biosynthetic process
SMUL_RS12980	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMUL_RS12990	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMUL_RS12995	COG0602	queuosine metabolic process
SMUL_RS13020	COG1702	phosphate starvation-inducible protein PhoH
SMUL_RS13030	COG2814	Major facilitator Superfamily
SMUL_RS13035	COG0477	Major facilitator Superfamily
SMUL_RS13045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMUL_RS13065	COG3787	Belongs to the UPF0306 family
SMUL_RS13070	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SMUL_RS13100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SMUL_RS13100	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMUL_RS13100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMUL_RS13100	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMUL_RS13105	COG0546	phosphoglycolate phosphatase activity
SMUL_RS13130	COG2818	Glycosylase
SMUL_RS13140	COG1979	alcohol dehydrogenase
SMUL_RS13150	COG0038	chloride channel
SMUL_RS13155	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SMUL_RS13170	COG4680	protein conserved in bacteria
SMUL_RS13175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMUL_RS13180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMUL_RS13225	COG3278	Belongs to the heme-copper respiratory oxidase family
SMUL_RS13230	COG0745	RESPONSE REGULATOR receiver
SMUL_RS13245	COG0505	Belongs to the CarA family
SMUL_RS13265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMUL_RS13270	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMUL_RS13275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMUL_RS13285	COG0546	phosphoglycolate phosphatase activity
SMUL_RS13290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMUL_RS13305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMUL_RS13310	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SMUL_RS13315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMUL_RS13330	COG0203	ribosomal protein L17
SMUL_RS13340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMUL_RS13345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMUL_RS13350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMUL_RS13355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SMUL_RS13365	COG0024	Methionine aminopeptidase
SMUL_RS13370	COG0201	protein transport
SMUL_RS13375	COG0200	Binds to the 23S rRNA
SMUL_RS13380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMUL_RS13385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SMUL_RS13390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMUL_RS13395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMUL_RS13410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMUL_RS13415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMUL_RS13420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMUL_RS13425	COG0255	Belongs to the universal ribosomal protein uL29 family
SMUL_RS13430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMUL_RS13435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMUL_RS13445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMUL_RS13450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMUL_RS13455	COG0089	rRNA binding
SMUL_RS13460	COG0088	Forms part of the polypeptide exit tunnel
SMUL_RS13465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMUL_RS13470	COG0051	transcription antitermination factor activity, RNA binding
SMUL_RS13485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMUL_RS13490	COG0672	)-iron permease
SMUL_RS13515	COG0577	efflux transmembrane transporter activity
SMUL_RS13515	COG1136	(ABC) transporter
SMUL_RS13535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMUL_RS13540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMUL_RS13545	COG0571	ribonuclease III activity
SMUL_RS13550	COG0328	RNA-DNA hybrid ribonuclease activity
SMUL_RS13560	COG0358	DNA primase activity
SMUL_RS13565	COG0137	argininosuccinate synthase activity
SMUL_RS13570	COG2201	protein-glutamate methylesterase activity
SMUL_RS13590	COG0840	transmembrane signaling receptor activity
SMUL_RS13595	COG2201	protein-glutamate methylesterase activity
SMUL_RS13600	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SMUL_RS13610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SMUL_RS13625	COG0840	transmembrane signaling receptor activity
SMUL_RS13630	COG0835	chemotaxis
SMUL_RS13635	COG0745	RESPONSE REGULATOR receiver
SMUL_RS13640	COG0484	heat shock protein binding
SMUL_RS13745	COG4206	TonB-dependent receptor
SMUL_RS13760	COG1918	ferrous iron import across plasma membrane
SMUL_RS13760	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SMUL_RS13765	COG1918	ferrous iron import across plasma membrane
SMUL_RS13775	COG4773	Receptor
SMUL_RS13800	COG0848	biopolymer transport protein
SMUL_RS13805	COG0811	peptide transport
SMUL_RS13825	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SMUL_RS13840	COG1011	Hydrolase
SMUL_RS13845	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SMUL_RS13850	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SMUL_RS13870	COG1280	lysine exporter protein (LysE YggA)
SMUL_RS13875	COG1090	epimerase
SMUL_RS13920	COG2962	Rard protein
SMUL_RS13930	COG0642	Histidine kinase
SMUL_RS13935	COG2194	sulfuric ester hydrolase activity
SMUL_RS13945	COG2200	EAL domain
SMUL_RS13955	COG4191	Histidine kinase
SMUL_RS13965	COG0840	transmembrane signaling receptor activity
SMUL_RS13980	COG1342	Belongs to the UPF0251 family
SMUL_RS13985	COG1968	undecaprenyl-diphosphatase activity
SMUL_RS13990	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SMUL_RS14015	COG1027	Aspartate ammonia-lyase
SMUL_RS14020	COG1027	Aspartate ammonia-lyase
SMUL_RS14025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SMUL_RS14030	COG0252	asparaginase activity
SMUL_RS14035	COG3852	Histidine kinase
SMUL_RS14040	COG0745	RESPONSE REGULATOR receiver
SMUL_RS14055	COG3177	Filamentation induced by cAMP protein fic
SMUL_RS14065	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMUL_RS14090	COG1136	(ABC) transporter
SMUL_RS14115	COG1333	cytochrome c biogenesis protein
SMUL_RS14115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SMUL_RS14120	COG3301	Polysulphide reductase, NrfD
SMUL_RS14125	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS14130	COG0545	Peptidyl-prolyl cis-trans isomerase
SMUL_RS14135	COG0484	heat shock protein binding
SMUL_RS14150	COG0840	transmembrane signaling receptor activity
SMUL_RS14175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMUL_RS14180	COG0586	Pfam SNARE associated Golgi protein
SMUL_RS14200	COG0848	biopolymer transport protein
SMUL_RS14205	COG0811	peptide transport
SMUL_RS14210	COG0709	Synthesizes selenophosphate from selenide and ATP
SMUL_RS14215	COG0425	Belongs to the sulfur carrier protein TusA family
SMUL_RS14250	COG4662	Binding-protein-dependent transport system inner membrane component
SMUL_RS14255	COG2998	abc-type tungstate transport system, permease component
SMUL_RS14260	COG1177	transmembrane transport
SMUL_RS14265	COG3842	ATPase activity
SMUL_RS14270	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMUL_RS14280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SMUL_RS14290	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS14335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMUL_RS14340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMUL_RS14355	COG0848	biopolymer transport protein
SMUL_RS14360	COG0811	peptide transport
SMUL_RS14390	COG0500	methyltransferase
SMUL_RS14400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMUL_RS14425	COG1917	Cupin 2, conserved barrel domain protein
SMUL_RS14425	COG4977	sequence-specific DNA binding
SMUL_RS14435	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS14440	COG3383	formate dehydrogenase (NAD+) activity
SMUL_RS14445	COG0243	molybdopterin cofactor binding
SMUL_RS14470	COG4191	Histidine kinase
SMUL_RS14475	COG0745	RESPONSE REGULATOR receiver
SMUL_RS14480	COG1921	L-seryl-tRNASec selenium transferase activity
SMUL_RS14505	COG1741	Belongs to the pirin family
SMUL_RS14540	COG0745	RESPONSE REGULATOR receiver
SMUL_RS14545	COG0642	Histidine kinase
SMUL_RS14580	COG2986	histidine ammonia-lyase
SMUL_RS14585	COG1028	Short-chain dehydrogenase reductase Sdr
SMUL_RS14620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMUL_RS14630	COG0513	Belongs to the DEAD box helicase family
SMUL_RS14660	COG1305	Transglutaminase-like
SMUL_RS14675	COG0745	RESPONSE REGULATOR receiver
SMUL_RS14690	COG0439	Biotin carboxylase
SMUL_RS14700	COG3665	Urea carboxylase-associated protein
SMUL_RS14705	COG3842	ATPase activity
SMUL_RS14710	COG2011	ABC-type metal ion transport system permease component
SMUL_RS14720	COG0642	Histidine kinase
SMUL_RS14725	COG0745	RESPONSE REGULATOR receiver
SMUL_RS14735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMUL_RS14740	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMUL_RS14750	COG1840	ABC-type Fe3 transport system, periplasmic component
SMUL_RS14755	COG3842	ATPase activity
SMUL_RS14765	COG0745	RESPONSE REGULATOR receiver
SMUL_RS14770	COG2205	protein histidine kinase activity
SMUL_RS14775	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SMUL_RS14780	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SMUL_RS14785	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SMUL_RS14790	COG0523	cobalamin synthesis protein
SMUL_RS14815	COG0700	Nucleoside recognition
SMUL_RS14820	COG3366	ferrous iron transmembrane transporter activity
SMUL_RS14825	COG1473	amidohydrolase
SMUL_RS14840	COG0300	oxidoreductase activity
SMUL_RS14855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMUL_RS14860	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SMUL_RS14865	COG2814	Major facilitator Superfamily
SMUL_RS14870	COG1238	metal cluster binding
SMUL_RS14890	COG0303	'Molybdopterin
SMUL_RS14895	COG0314	molybdopterin synthase activity
SMUL_RS14910	COG1104	cysteine desulfurase activity
SMUL_RS14915	COG1157	protein secretion by the type III secretion system
SMUL_RS14920	COG0302	gtp cyclohydrolase
SMUL_RS14925	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMUL_RS14930	COG0740	serine-type endopeptidase activity
SMUL_RS14950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SMUL_RS14950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMUL_RS14955	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMUL_RS14960	COG2022	thiamine diphosphate biosynthetic process
SMUL_RS15035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SMUL_RS15040	COG0431	NADPH-dependent FMN reductase
SMUL_RS15040	COG1053	succinate dehydrogenase
SMUL_RS15040	COG3976	FMN-binding domain protein
SMUL_RS15045	COG0644	oxidoreductase
SMUL_RS15100	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS15105	COG0243	molybdopterin cofactor binding
SMUL_RS15125	COG0745	RESPONSE REGULATOR receiver
SMUL_RS15130	COG0642	Histidine kinase
SMUL_RS15135	COG1012	belongs to the aldehyde dehydrogenase family
SMUL_RS15150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMUL_RS15165	COG2183	response to ionizing radiation
SMUL_RS15195	COG0840	transmembrane signaling receptor activity
SMUL_RS15200	COG0778	Nitroreductase
SMUL_RS15235	COG0577	efflux transmembrane transporter activity
SMUL_RS15240	COG1136	(ABC) transporter
SMUL_RS15265	COG1472	Belongs to the glycosyl hydrolase 3 family
SMUL_RS15275	COG0475	glutathione-regulated potassium exporter activity
SMUL_RS15280	COG1280	lysine exporter protein (LysE YggA)
SMUL_RS15295	COG0454	-acetyltransferase
SMUL_RS15300	COG0431	NADPH-dependent FMN reductase
SMUL_RS15320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SMUL_RS15325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMUL_RS15345	COG0745	RESPONSE REGULATOR receiver
SMUL_RS15350	COG0642	Histidine kinase
SMUL_RS15355	COG3842	ATPase activity
SMUL_RS15365	COG1840	ABC-type Fe3 transport system, periplasmic component
SMUL_RS15380	COG0175	sulfate reduction
SMUL_RS15385	COG0175	sulfate reduction
SMUL_RS15390	COG2895	sulfate adenylyltransferase (ATP) activity
SMUL_RS15400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMUL_RS15410	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SMUL_RS15420	COG2873	o-acetylhomoserine
SMUL_RS15430	COG0482	sulfurtransferase activity
SMUL_RS15455	COG5002	protein histidine kinase activity
SMUL_RS15465	COG2203	Gaf domain
SMUL_RS15465	COG2199	diguanylate cyclase activity
SMUL_RS15480	COG0745	RESPONSE REGULATOR receiver
SMUL_RS15520	COG4232	protein-disulfide reductase activity
SMUL_RS15525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMUL_RS15530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SMUL_RS15535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMUL_RS15545	COG0243	molybdopterin cofactor binding
SMUL_RS15560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SMUL_RS15570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SMUL_RS15605	COG0577	efflux transmembrane transporter activity
SMUL_RS15605	COG1136	(ABC) transporter
SMUL_RS15660	COG1136	(ABC) transporter
SMUL_RS15670	COG2205	protein histidine kinase activity
SMUL_RS15670	COG4191	Histidine kinase
SMUL_RS15670	COG0745	RESPONSE REGULATOR receiver
SMUL_RS15685	COG0243	molybdopterin cofactor binding
SMUL_RS15695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SMUL_RS15710	COG0861	Integral membrane protein TerC family
SMUL_RS15715	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMUL_RS15720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMUL_RS15725	COG4303	Ethanolamine ammonia lyase large subunit
SMUL_RS15730	COG4302	ethanolamine ammonia-lyase activity
SMUL_RS15735	COG0531	amino acid
SMUL_RS15740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMUL_RS15745	COG0281	malic enzyme
SMUL_RS15745	COG0280	phosphate acetyltransferase
SMUL_RS15750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMUL_RS15760	COG0439	Biotin carboxylase
SMUL_RS15765	COG0511	ligase activity, forming carbon-carbon bonds
SMUL_RS15770	COG0717	Belongs to the dCTP deaminase family
SMUL_RS15785	COG3041	Addiction module toxin RelE StbE family
SMUL_RS15795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMUL_RS15810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMUL_RS15815	COG1086	Polysaccharide biosynthesis protein
SMUL_RS15820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SMUL_RS15825	COG1083	cytidylyl-transferase
SMUL_RS15835	COG2089	acid synthase
SMUL_RS15855	COG0318	PFAM AMP-dependent synthetase and ligase
SMUL_RS15860	COG1216	Glycosyl transferase, family 2
SMUL_RS15865	COG0562	UDP-galactopyranose mutase
SMUL_RS15885	COG0110	maltose O-acetyltransferase activity
SMUL_RS15895	COG2226	methyltransferase
SMUL_RS15925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SMUL_RS15930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMUL_RS15935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMUL_RS15940	COG0372	Belongs to the citrate synthase family
SMUL_RS15955	COG0148	phosphopyruvate hydratase activity
SMUL_RS15960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMUL_RS15965	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SMUL_RS15970	COG1987	bacterial-type flagellum assembly
SMUL_RS15975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMUL_RS15980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMUL_RS16010	COG1408	metallophosphoesterase
SMUL_RS16015	COG1115	amino acid carrier protein
SMUL_RS16020	COG2233	PERMEase
SMUL_RS16025	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SMUL_RS16030	COG0575	Belongs to the CDS family
SMUL_RS16045	COG1929	Belongs to the glycerate kinase type-1 family
SMUL_RS16050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMUL_RS16070	COG0753	catalase activity
SMUL_RS16075	COG0450	alkyl hydroperoxide reductase
SMUL_RS16080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMUL_RS16090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMUL_RS16095	COG0746	molybdenum cofactor guanylyltransferase activity
SMUL_RS16130	COG0724	RNA recognition motif
SMUL_RS16135	COG0315	cyclic pyranopterin monophosphate synthase activity
SMUL_RS16175	COG3328	transposase activity
SMUL_RS16210	COG1140	nitrate reductase beta subunit
SMUL_RS16220	COG2897	thiosulfate sulfurtransferase activity
SMUL_RS16230	COG0489	protein tyrosine kinase activity
SMUL_RS16275	COG0670	Belongs to the BI1 family
SMUL_RS16330	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS16335	COG0243	molybdopterin cofactor binding
SMUL_RS16340	COG4106	trans-aconitate 2-methyltransferase activity
SMUL_RS16350	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMUL_RS16355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SMUL_RS16365	COG0233	cytoplasmic translational termination
SMUL_RS16370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMUL_RS16395	COG1704	LemA family
SMUL_RS16400	COG1217	gtp-binding protein TYPA
SMUL_RS16415	COG1749	Flagellar hook protein flgE
SMUL_RS16420	COG1749	Flagellar hook protein flgE
SMUL_RS16425	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SMUL_RS16430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SMUL_RS16440	COG4251	negative regulation of phosphorylation
SMUL_RS16440	COG3706	GGDEF domain
SMUL_RS16440	COG2203	Gaf domain
SMUL_RS16440	COG5001	Diguanylate cyclase
SMUL_RS16450	COG5001	Diguanylate cyclase
SMUL_RS16475	COG3706	GGDEF domain
SMUL_RS16485	COG0840	transmembrane signaling receptor activity
SMUL_RS16495	COG0109	protoheme IX farnesyltransferase activity
SMUL_RS16545	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SMUL_RS16545	COG3264	Mechanosensitive ion channel
SMUL_RS16555	COG2205	protein histidine kinase activity
SMUL_RS16555	COG0784	Response regulator, receiver
SMUL_RS16590	COG2205	protein histidine kinase activity
SMUL_RS16590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUL_RS16625	COG0437	4 iron, 4 sulfur cluster binding
SMUL_RS16675	COG0582	viral genome integration into host DNA
SMUL_RS16695	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SMUL_RS16700	COG2205	protein histidine kinase activity
SMUL_RS16700	COG4999	Histidine kinase
SMUL_RS16700	COG3437	response regulator, receiver
SMUL_RS16700	COG3850	Histidine kinase
SMUL_RS16725	COG3706	GGDEF domain
SMUL_RS16740	COG3381	protein complex oligomerization
SMUL_RS16745	COG5002	protein histidine kinase activity
SMUL_RS16745	COG2205	protein histidine kinase activity
SMUL_RS16745	COG0784	Response regulator, receiver
SMUL_RS16825	COG5001	Diguanylate cyclase
SMUL_RS16825	COG5002	protein histidine kinase activity
SMUL_RS16825	COG3447	MASE1 domain protein
SMUL_RS16830	COG1120	ATPase activity
SMUL_RS16835	COG1120	ATPase activity
SMUL_RS16875	COG1216	Glycosyl transferase, family 2
SMUL_RS16880	COG1216	Glycosyl transferase, family 2